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Omentin associates with serum metabolite profiles indicating lower diabetes risk: KORA F4 Study BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-03-01 Jacqueline M Ratter-Rieck, Mengya Shi, Karsten Suhre, Cornelia Prehn, Jerzy Adamski, Wolfgang Rathmann, Barbara Thorand, Michael Roden, Annette Peters, Rui Wang-Sattler, Christian Herder
Introduction Circulating omentin levels have been positively associated with insulin sensitivity. Although a role for adiponectin in this relationship has been suggested, underlying mechanisms remain elusive. In order to reveal the relationship between omentin and systemic metabolism, this study aimed to investigate associations of serum concentrations of omentin and metabolites. Research design and
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Greater persistence and adherence to basal insulin therapy is associated with lower healthcare utilization and medical costs in patients with type 2 diabetes: a retrospective database analysis BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-03-01 Vanita R Aroda, Nick Nielsen, Kamal K Mangla, Jasjit Multani, Victoria Divino, Tarlan Namvar, Jigar Rajpura
Introduction We aimed to assess persistence and adherence to basal insulin therapy, their association with all-cause healthcare resource utilization (HCRU) and direct medical costs, and predictors of persistence and adherence in adults with type 2 diabetes. Research design and methods A retrospective cohort study was conducted with US adults with type 2 diabetes initiating basal insulin therapy between
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Variation in the relationship between fasting glucose and HbA1c: implications for the diagnosis of diabetes in different age and ethnic groups BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-03-01 Yashesvini Ram, Yongjin Xu, Alan Cheng, Timothy Dunn, Ramzi A Ajjan
Introduction Identify non-glycemic factors affecting the relationship between fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c), in order to refine diabetes diagnostic criteria. Research design and methods Relationship between FPG–HbA1c was assessed in 12 531 individuals from 2001 to 2018 US National Health and Nutrition Examination Survey. Using a recently described method, FPG and HbA1c
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MicroRNA-5010-5p ameliorates high-glucose induced inflammation in renal tubular epithelial cells by modulating the expression of PPP2R2D BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-03-01 Sunghee Choi, Mithun Kumer Sarker, Mi Ra Yu, Haekyung Lee, Soon Hyo Kwon, Jin Seok Jeon, Hyunjin Noh, Hyoungnae Kim
Introduction We previously reported the significant upregulation of eight circulating exosomal microRNAs (miRNAs) in patients with diabetic kidney disease (DKD). However, their specific roles and molecular mechanisms in the kidney remain unknown. Among the eight miRNAs, we evaluated the effects of miR-5010-5p on renal tubular epithelial cells under diabetic conditions in this study. Research design
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A static glucose-stimulated insulin secretion (sGSIS) assay that is significantly predictive of time to diabetes reversal in the human islet bioassay BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-03-01 Ruth Damaris Molano, Antonello Pileggi, Hubert M Tse, Cherie L Stabler, Christopher A Fraker
Introduction Static incubation (static glucose-stimulated insulin secretion, sGSIS) is a measure of islet secretory function. The Stimulation Index (SI; insulin produced in high glucose/insulin produced in low glucose) is currently used as a product release criterion of islet transplant potency. Research design and methods Our hypothesis was that the Delta, insulin secreted in high glucose minus insulin
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Cost-effectiveness analysis of two interventions to promote physical activity in a multiethnic population at high risk of diabetes: an economic evaluation of the 48-month PROPELS randomized controlled trial BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-03-01 Laura Ellen Heathcote, Daniel J Pollard, Alan Brennan, Melanie J Davies, Helen Eborall, Charlotte L Edwardson, Michael Gillett, Laura J Gray, Simon J Griffin, Wendy Hardeman, Joseph Henson, Kamlesh Khunti, Stephen Sharp, Stephen Sutton, Thomas Yates
Introduction Physical activity (PA) is protective against type 2 diabetes (T2D). However, data on pragmatic long-term interventions to reduce the risk of developing T2D via increased PA are lacking. This study investigated the cost-effectiveness of a pragmatic PA intervention in a multiethnic population at high risk of T2D. Materials and methods We adapted the School for Public Health Research diabetes
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Landscape of pharmacogenetic variants associated with non-insulin antidiabetic drugs in the Indian population BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-03-01 Ambily Sivadas, S Sahana, Bani Jolly, Rahul C Bhoyar, Abhinav Jain, Disha Sharma, Mohamed Imran, Vigneshwar Senthivel, Mohit Kumar Divakar, Anushree Mishra, Arpita Mukhopadhyay, Greg Gibson, KM Venkat Narayan, Sridhar Sivasubbu, Vinod Scaria, Anura V Kurpad
Introduction Genetic variants contribute to differential responses to non-insulin antidiabetic drugs (NIADs), and consequently to variable plasma glucose control. Optimal control of plasma glucose is paramount to minimizing type 2 diabetes-related long-term complications. India’s distinct genetic architecture and its exploding burden of type 2 diabetes warrants a population-specific survey of NIAD-associated
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Loneliness and the risk of type 2 diabetes BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-03-01 Siri Rosenkilde, Sofie Have Hoffmann, Anne Bonde Thorsted, Trine Allerslev Horsbøl, Katrine Rich Madsen, Sara Fokdal Lehn, Allan Kofoed-Enevoldsen, Peter Bindslev Iversen, Marie Stjerne Grønkjær, Lau Caspar Thygesen
Introduction The incidence of type 2 diabetes is increasing globally. Recent research suggests that loneliness could be a potential risk factor for the development of type 2 diabetes. We aimed to investigate the association between loneliness and type 2 diabetes and the modifying effect of mental disorders. Research design and methods We conducted a prospective study including 465 290 adults (aged
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Pilot feasibility and efficacy of a strategy to sustain A1C improvement among diverse adults with type 2 diabetes completing a diabetes care management program BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-03-01 Alex Renato Montero, Carine M Nassar, Saba Ahmed, Michelle Magee
Introduction Evidence-based strategies are needed to sustain improvements in outcomes following diabetes care management (DCM) programs. We examined the impact of Boot Camp-Plus (BC-Plus), an innovative sustaining strategy, on A1C among adults with type 2 diabetes completing a 3-month Diabetes Boot Camp (DBC). This health system sponsored program consisted of diabetes self-management education and
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Role of perirenal adiposity in renal dysfunction among CKD individuals with or without diabetes: a Japanese cross-sectional study BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-03-01 Teruyuki Kono, Gulinu Maimaituxun, Hayato Tanabe, Moritake Higa, Haruka Saito, Kenichi Tanaka, Hiroaki Masuzaki, Masataka Sata, Junichiro J. Kazama, Michio Shimabukuro
Introduction It remains unclear whether increased perirenal fat (PRF) accumulation is equally related to renal involvement in patients with and without diabetes mellitus (DM). We evaluated the association between PRF volume (PRFV) and low glomerular filtration rate (GFR) and proteinuria in people with or without type 2 diabetes mellitus (T2DM). Research design and methods We performed a cross-sectional
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External validation and application of the Diabetes Population Risk Tool (DPoRT) for prediction of type 2 diabetes onset in the US population BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-03-01 Kathy Kornas, Christopher Tait, Ednah Negatu, Laura C Rosella
Introduction Characterizing diabetes risk in the population is important for population health assessment and diabetes prevention planning. We aimed to externally validate an existing 10-year population risk model for type 2 diabetes in the USA and model the population benefit of diabetes prevention approaches using population survey data. Research design and methods The Diabetes Population Risk Tool
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Longitudinal changes in diet quality and food intake before and after diabetes awareness in American adults: the Coronary Artery Risk Development in Young Adults (CARDIA) study BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-03-01 EunSeok Cha, Yuni Choi, Michael Bancks, Melissa Spezia Faulkner, Sandra B Dunbar, Guillermo E Umpierrez, Jared Reis, Mercedes R Carnethon, James M Shikany, Fengxia Yan, David R Jacobs
Introduction Limited longitudinal research is available examining how American adults make dietary changes after learning they have diabetes. We examined the associations between diabetes awareness and changes in dietary quality and food intake in a prospective cohort from the Coronary Artery Risk Development in Young Adults (CARDIA) study. Research design and methods A nested case-control design was
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Colonic epithelial hypoxia remains constant during the progression of diabetes in male UC Davis type 2 diabetes mellitus rats BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-03-01 Brian D Piccolo, James L Graham, Leslie Tabor-Simecka, Christopher E Randolph, Becky Moody, Michael S Robeson, Ping Kang, Renee Fox, Renny Lan, Lindsay Pack, Noah Woford, Laxmi Yeruva, Tanya LeRoith, Kimber L Stanhope, Peter J Havel
Introduction Colonocyte oxidation of bacterial-derived butyrate has been reported to maintain synergistic obligate anaerobe populations by reducing colonocyte oxygen levels; however, it is not known whether this process is disrupted during the progression of type 2 diabetes. Our aim was to determine whether diabetes influences colonocyte oxygen levels in the University of California Davis type 2 diabetes
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Postprandial glucose variability and clusters of sex hormones, liver enzymes, and cardiometabolic factors in a South African cohort of African ancestry BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-03-01 Bontle Masango, Julia H Goedecke, Michèle Ramsay, Karl-Heinz Storbeck, Lisa K Micklesfield, Tinashe Chikowore
Introduction This study aimed to, first, determine the clusters of sex hormones, liver enzymes, and cardiometabolic factors associated with postprandial glucose (PPG) and, second to evaluate the variation these clusters account for jointly and independently with polygenic risk scores (PRSs) in South Africans of African ancestry men and women. Research design and methods PPG was calculated as the integrated
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Burden of impaired awareness of hypoglycemia in people with diabetes undergoing hemodialysis BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-02-01 Hellena Hailu Habte-Asres, Yutong Jiang, Miranda Rosenthal, David Collins Wheeler
Introduction Impaired awareness of hypoglycemia (IAH) refers to a diminished capacity to detect hypoglycemia. IAH can result in severe and even life-threatening outcomes for individuals with diabetes, especially those in advanced stages of the disease. This study aimed to assess the prevalence of IAH in people with diabetes on hemodialysis. Research design and methods We conducted a single-center audit
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Access to telehealth and changes in diabetes care patterns during the pandemic: evidence from a large integrated health system in the Southeast USA BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-02-01 Sofia A Oviedo, Bennett McDonald, Jennifer C Gander, Mohammed K Ali, Jessica L Harding
Introduction To examine the role of telehealth in diabetes care and management during versus pre-COVID-19 pandemic. Research design and methods We included adults (≥18 years) with prevalent diabetes as of January 1, 2018, and continuously enrolled at Kaiser Permanente Georgia through December 31, 2021 (n=22,854). We defined pre (2018–2019) and during COVID-19 (2020–2021) periods. Logistic generalized
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Use of machine learning to identify characteristics associated with severe hypoglycemia in older adults with type 1 diabetes: a post-hoc analysis of a case–control study BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-02-01 Nikki L B Freeman, Rashmi Muthukkumar, Ruth S Weinstock, M Victor Wickerhauser, Anna R Kahkoska
Introduction Severe hypoglycemia (SH) in older adults (OAs) with type 1 diabetes is associated with profound morbidity and mortality, yet its etiology can be complex and multifactorial. Enhanced tools to identify OAs who are at high risk for SH are needed. This study used machine learning to identify characteristics that distinguish those with and without recent SH, selecting from a range of demographic
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Cancer risk according to fasting blood glucose trajectories: a population-based cohort study BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-02-01 Thi Minh Thu Khong, Thi Tra Bui, Hee-Yeon Kang, Jinhee Lee, Eunjung Park, Jin-Kyoung Oh
Introduction Diabetes mellitus is known to increase the risk of cancer. Fasting blood glucose (FBG) levels can be changed over time. However, the association between FBG trajectory and cancer risk has been insufficiently studied. This research aims to examine the relationship between FBG trajectories and cancer risk in the Korean population. Research design and methods We analyzed data from the National
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Predictive biomarkers of rapidly developing insulin deficiency in children with type 1 diabetes BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-02-01 Per Lundkvist, Annika Grönberg, Per-Ola Carlsson, Johnny Ludvigsson, Daniel Espes
Introduction The rate of progression to complete insulin deficiency varies greatly in type 1 diabetes. This constitutes a challenge, especially when randomizing patients in intervention trials aiming to preserve beta cell function. This study aimed to identify biomarkers predictive of either a rapid or slow disease progression in children with new-onset type 1 diabetes. Research design and methods
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Review of the direct and indirect effects of hyperglycemia on the HPA axis in T2DM and the co-occurrence of depression BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-02-01 Palesa Mosili, Bongeka Cassandra Mkhize, Ntethelelo Hopewell Sibiya, Phikelelani Sethu Ngubane, Andile Khathi
Type 2 diabetes mellitus (T2DM) is characterized by persistent hyperglycemia which is further associated with hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis. Several studies have shown that HPA axis hyperactivity is heightened in the chronic hyperglycemic state with severe hyperglycemic events more likely to result in a depressive disorder. The HPA axis is also regulated by the immune
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Enhanced prediction of abnormal glucose tolerance using an extended non-invasive risk score incorporating routine renal biochemistry BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-02-01 Jie He, Baoqi Fan, Eric S H Lau, Natural Chu, Noel Yat Hey Ng, Kathy Ho Ting Leung, Emily W M Poon, Alice Pik Shan Kong, Ronald Ching Wan Ma, Andrea O Y Luk, Juliana C N Chan, Elaine Chow
Introduction Type 2 diabetes is preventable in subjects with impaired glucose tolerance based on 2-hour plasma glucose (2hPG) during 75 g oral glucose tolerance test (OGTT). We incorporated routine biochemistry to improve the performance of a non-invasive diabetes risk score to identify individuals with abnormal glucose tolerance (AGT) defined by 2hPG≥7.8 mmol/L during OGTT. Research design and methods
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Racial differences in measures of glycemia in the Vitamin D and Type 2 Diabetes (D2d) Study: a secondary analysis of a randomized trial BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-02-01 Erin S LeBlanc, Anastassios G Pittas, Jason Nelson, Ranee Chatterjee, Neda Rasouli, Mary K Rhee, Richard E Pratley, Cyrus V Desouza, Lisa M Neff, Anne M Peters, Samuel Dagogo-Jack, Daniel S Hsia
Introduction Understanding how race may influence the association between A1c and glycemia can improve diabetes screening. We sought to determine whether, for a given A1c level, glucose levels during an oral glucose tolerance test (OGTT) differed by race. Research design and methods From data collected at 22 US clinical sites, we conducted a cross-sectional study of concurrently measured A1c and OGTT
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Association between lower extremity arterial calcification and coronary arterial calcification in a population at increased risk of cardiovascular disease BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-02-01 Romain Meer, Anna G Hoek, Emma J Bouman, Teddo Doesburg, Petra J M Elders, Pim A de Jong, Joline Beulens, UCC-SMART Study Group
Introduction There is conflicting evidence whether lower extremity arterial calcification coincides with coronary arterial calcification (CAC). The aims of this study were to investigate the associations between (1) femoral and crural calcification with CAC, and (2) femoral and crural calcification pattern with CAC. Research design and methods This cross-sectional study included 405 individuals (74%
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Young-onset type 2 diabetes and retinopathy: evidence of an adverse phenotype BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-01-01 Soon H Song
The landscape of type 2 diabetes (T2D) has changed with an increasing number of people being diagnosed under age 40 years. The principal concern with young-onset T2D is the early development of complications, with associated morbidity and premature mortality. In view of the potential impact on the working-age population and the associated personal, societal and economic ramifications, it is important
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High prevalence of retinopathy in young-onset type 2 diabetes and possible sex differences: insights from Norwegian general practice BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-01-01 Katrina Tibballs, Anne Karen Jenum, Lars Kirkebøen, Tore Julsrud Berg, Tor Claudi, John Graham Cooper, Kjersti Nøkleby, Sverre Sandberg, Jørund Straand, Esben Selmer Buhl
Introduction People with young-onset type 2 diabetes (YOD), defined as diabetes diagnosis before age 40, have a high lifetime risk of vascular complications. We aimed to estimate the prevalence of YOD among adults with type 2 diabetes (T2D) in Norwegian general practice and explore associations between age at diabetes diagnosis and retinopathy overall and in men and women. Research design and methods
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Ocular microvascular complications in diabetic retinopathy: insights from machine learning BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-01-01 Thiara S Ahmed, Janika Shah, Yvonne N B Zhen, Jacqueline Chua, Damon W K Wong, Simon Nusinovici, Rose Tan, Gavin Tan, Leopold Schmetterer, Bingyao Tan
Introduction Diabetic retinopathy (DR) is a leading cause of preventable blindness among working-age adults, primarily driven by ocular microvascular complications from chronic hyperglycemia. Comprehending the complex relationship between microvascular changes in the eye and disease progression poses challenges, traditional methods assuming linear or logistical relationships may not adequately capture
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Unfavorable social determinants of health and risk of mortality in adults with diabetes: findings from the National Health Interview Survey BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-01-01 Ryan Chang, Jerrin Philip, Umair Javed, Anoop Titus, Syed Karam Gardezi, Harun Kundi, Raman Yousefzai, Adnan A Hyder, Elias Mossialos, Khurram Nasir, Zulqarnain Javed
Introduction Understanding the role of social determinants of health as predictors of mortality in adults with diabetes may help improve health outcomes in this high-risk population. Using population-based, nationally representative data, this study investigated the cumulative effect of unfavorable social determinants on all-cause mortality in adults with diabetes. Research design and methods We used
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Incident dementia risk among patients with type 2 diabetes receiving metformin versus alternative oral glucose-lowering therapy: an observational cohort study using UK primary healthcare records BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-01-01 William Doran, Louis Tunnicliffe, Rutendo Muzambi, Christopher T Rentsch, Krishnan Bhaskaran, Liam Smeeth, Carol Brayne, Dylan M Williams, Nish Chaturvedi, Sophie V Eastwood, Susanna J Dunachie, Rohini Mathur, Charlotte Warren-Gash
Introduction 4.2 million individuals in the UK have type 2 diabetes, a known risk factor for dementia and mild cognitive impairment (MCI). Diabetes treatment may modify this association, but existing evidence is conflicting. We therefore aimed to assess the association between metformin therapy and risk of incident all-cause dementia or MCI compared with other oral glucose-lowering therapies (GLTs)
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Effectiveness of SARS-CoV-2 primary vaccines and boosters in patients with type 2 diabetes mellitus in Hungary (HUN-VE 4 Study) BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-01-01 Gergő A Molnár, Zoltán Vokó, Gábor Sütő, György Rokszin, Dávid Nagy, György Surján, Orsolya Surján, Péter Nagy, István Kenessey, András Wéber, Mihály Pálosi, Cecília Müller, Miklós Kásler, István Wittmann, Zoltan Kiss
Introduction Type 2 diabetes mellitus is a risk factor for severe COVID-19 infection and is associated with increased risk of complications. The present study aimed to investigate effectiveness and persistence of different COVID vaccines in persons with or without diabetes during the Delta wave in Hungary. Research design and methods Data sources were the national COVID-19 registry data from the National
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Diabetes and chronic kidney disease in Chinese adults: a population-based cohort study BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-01-01 Xue Wang, Lu Chen, Kexiang Shi, Jun Lv, Dianjianyi Sun, Pei Pei, Ling Yang, Yiping Chen, Huaidong Du, Jiaqiu Liu, Xiaoming Yang, Maxim Barnard, Junshi Chen, Zhengming Chen, Liming Li, Canqing Yu
Introduction Cohort evidence of the association of diabetes mellitus (DM) with chronic kidney disease (CKD) is limited. Previous studies often describe patients with kidney disease and diabetes as diabetic kidney disease (DKD) or CKD, ignoring other subtypes. The present study aimed to assess the prospective association of diabetes status (no diabetes, pre-diabetes, screened diabetes, previously diagnosed
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Impact of sodium-glucose cotransporter 2 inhibitors on cardiovascular outcomes in patients with chronic kidney disease: propensity score matched analysis BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-01-01 Wen Sun, Bryan P Yan
Type 2 diabetes mellitus (T2DM) is the most common cause of chronic kidney disease (CKD).1 Age-adjusted prevalence of CKD in patients with T2DM is approximately 40%, of which majority are mild to moderate.2 The risk gradient of cardiovascular (CV) mortality in CKD increased linearly with decreased glomerular filtration rate (GFR) but changed little when GFR was greater than 75.3 Sodium-glucose cotransporter
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Adverse perinatal outcomes in gestational diabetes mellitus with and without SARS-CoV-2 infection during pregnancy: results from two nationwide registries in Germany BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-01-01 Tatjana P Liedtke, Katharina S Weber, Heinke Adamczewski, Dietmar Weber, Babett Ramsauer, Ute M Schaefer-Graf, Tanja Groten, Eike A Strathmann, Wolfgang Lieb, Mario Rüdiger, Ulrich Pecks, Helmut J Kleinwechter
Introduction Pregnancy is a known independent risk factor for a severe course of COVID-19. The relationship of SARS-CoV-2 infection and gestational diabetes mellitus (GDM) on neonatal outcomes is unclear. Our aim was to determine if SARS-CoV-2 infection represents an independent risk factor for adverse perinatal outcomes in pregnancy with GDM. Research design and methods We compared data from two German
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Correction: Normative data on cardiovascular autonomic function in Greenlandic Inuit BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-01-01 American Diabetes Association
Christensen MMB, Hansen CS, Fleischer J, et al . Normative data on cardiovascular autonomic function in Greenlandic Inuit. BMJ Open Diabetes Res Care , 2021;9:e002121. doi: 10.1136/bmjdrc-2021-002121. This article was previously published with an error. The original paper presented normative thresholds of cardiovascular autonomic function in Greenlanders without diabetes. The levels of the normative
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Effects of sodium-glucose cotransporter-2 (SGLT-2) inhibitors on serum uric acid levels in patients with chronic kidney disease: a systematic review and network meta-analysis BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-01-01 Linli Zhang, Fan Zhang, Yan Bai, Liuyan Huang, Yifei Zhong, Xianwen Zhang
Elevated serum uric acid levels are an independent predictor of occurrence and development of chronic kidney disease (CKD) and are strongly associated with prognosis. Several clinical trials have demonstrated the benefits of sodium-glucose cotransporter-2 (SGLT-2) inhibitors. To evaluate and rank the effects and safety of various SGLT-2 for serum uric acid levels in patients with CKD. We performed
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Association of urinary albumin-to-creatinine ratio with cardiometabolic risk markers and pre-diabetes in adults with normoglycemia, normoalbuminuria, and normotension with parental type 2 diabetes BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-01-01 Matthew Everett, Natasha Rushing, Peace Asuzu, Jim Wan, Samuel Dagogo-Jack
Introduction This is a post hoc analysis of urinary albumin-to-creatinine ratio (uACR) within the normoalbuminuric range in relation to cardiometabolic risk factors among initially normoglycemic, normotensive participants in the Pathobiology of Prediabetes in a Biracial Cohort (POP-ABC) Study. Research design and methods 308 healthy African American (AA) and European American (EA) participants in the
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Increased glycemic variability in pregnant women with Roux-en-Y gastric bypass compared with sleeve gastrectomy BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-01-01 Kleopatra Alexiadou, Saleem Ansari, Bryony Jones, Christina Yu, Anne Dornhorst, Nick Oliver, Christos Tsironis, Sanjay Purkayastha, Ahmed Ahmed, Rochan Agha-Jaffar, Bernard Khoo, Tricia M-M Tan
Introduction Bariatric surgery is associated with adverse pregnancy outcomes such as reduced birth weight and premature birth. One possible mechanism for this is increased glycemic variability (GV) which occurs after bariatric surgery. The objective of this study was to compare the effect of Roux-en-Y gastric bypass (RYGB) versus vertical sleeve gastrectomy (SG) on GV during pregnancy and to investigate
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Association between brain imaging biomarkers and continuous glucose monitoring-derived glycemic control indices in Japanese patients with type 2 diabetes mellitus BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-01-01 Chikako Inoue, Yoshiki Kusunoki, Mana Ohigashi, Keiko Osugi, Kazuhiro Kitajima, Ayako Takagi, Maki Inoue, Chisako Yagi, Taku Tsunoda, Miki Kakutani, Manabu Kadoya, Kosuke Konishi, Tomoyuki Katsuno, Hidenori Koyama
Introduction Although type 2 diabetes mellitus (T2DM) is associated with alterations in brain structure, the relationship between glycemic control indices and brain imaging markers remains unclear. This study aimed to investigate the association between continuous glucose monitoring (CGM)-derived glycemic control indices and brain imaging biomarkers assessed by MRI. Research design and methods This
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Continuous intrafemoral artery infusion of urokinase improves diabetic foot ulcers healing and decreases cardiovascular events in a long-term follow-up study BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-01-01 Jiayue Tong, Junxia Zhang, Lin Xiang, Shuguang Li, Jinling Xu, Guangping Zhu, Jing Dong, Yangyang Cheng, Hujun Ren, Min Liu, Ling Yue, Guangda Xiang
Introduction Diabetic foot ulcer (DFU) is a disabling complication of diabetes mellitus. Here, we attempted to assess whether long-term intrafemoral artery infusion of low-dose urokinase therapy improved DFUs and decreased cardiovascular events in patients with DFUs. Research design and methods This trial was a single-center, randomized, parallel study. A total of 195 patients with DFU were randomized
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Association of GLP-1 secretion with parameters of glycemic control in women after gestational diabetes mellitus BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-01-01 Eleni Pappa, Kristina Busygina, Saori Harada, Hana Hermann, Cornelia Then, Andreas Lechner, Uta Ferrari, Jochen Seissler
Introduction Women with a history of gestational diabetes mellitus (GDM) are at high risk of developing type 2 diabetes, while the exact mechanisms underlying its pathophysiology are still unclear. We investigated the association of glucagon-like peptide-1 (GLP-1) response to oral glucose with parameters of glycemic control in women with previous GDM in the prospective PPSDiab (Prediction, Prevention
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Should insulin resistance (HOMA-IR), insulin secretion (HOMA-β), and visceral fat area be considered for improving the performance of diabetes risk prediction models BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2024-01-01 Huan Hu, Tohru Nakagawa, Toru Honda, Shuichiro Yamamoto, Tetsuya Mizoue
Introduction Insulin resistance and defects in pancreatic beta cells are the two major pathophysiologic abnormalities that underlie type 2 diabetes. In addition, visceral fat area (VFA) is reported to be a stronger predictor for diabetes than body mass index (BMI). Here, we tested whether the performance of diabetes prediction models could be improved by adding HOMA-IR and HOMA-β and replacing BMI
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Serum osmolality was non-linearly associated with the risk of all-cause and cardiovascular mortality in patients with diabetes BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2023-12-01 Tingting Hu, Chenglin Li, Tao Wang, Hailang Liu, Jin Geng, Aifeng Gong
Aims This study aimed to evaluate the relationship between both low and high osmolarity and the risk of all-cause and cause-specific mortality in diabetic population. Methods All participants were included from the National Health and Nutrition Examination Survey 1999–2014. Baseline serum osmolality was determined from laboratory tests and cause of death from national death records. HRs and 95% CIs
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Various screening and diagnosis approaches for gestational diabetes mellitus and adverse pregnancy outcomes: a secondary analysis of a randomized non-inferiority field trial BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2023-12-01 Fahimeh Ramezani Tehrani, Ali Sheidaei, Maryam Rahmati, Farshad Farzadfar, Mahsa Noroozzadeh, Farhad Hosseinpanah, Mehrandokht Abedini, Farzad Hadaegh, Majid Valizadeh, Farahnaz Torkestani, Davood Khalili, Faegheh Firouzi, Masoud Solaymani-Dodaran, Afshin Ostovar, Fereidoun Azizi, Samira Behboudi-Gandevani
Introduction We evaluate which screening and diagnostic approach resulted in the greatest reduction in adverse pregnancy outcomes due to increased treatment. Research design and methods This study presents a secondary analysis of a randomized community non-inferiority trial conducted among pregnant women participating in the GULF Study in Iran. A total of 35 430 pregnant women were randomly assigned
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Effects of the ABCC8 R1420H loss-of-function variant on beta-cell function, diabetes incidence, and retinopathy BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2023-12-01 Elsa Vazquez Arreola, William C Knowler, Leslie J Baier, Robert L Hanson
Introduction The ABCC8 gene regulates insulin secretion and plays a critical role in glucose homeostasis. The effects of an ABCC8 R1420H loss-of-function variant on beta-cell function, incidence of type 2 diabetes, and age-at-onset, prevalence, and progression of diabetes complications were assessed in a longitudinal study in American Indians. Research design and methods We analyzed beta-cell function
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Comorbid status in patients with osteomyelitis is associated with long-term incidence of extremity amputation BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2023-12-01 Brian M Schmidt, Toby P Keeney-Bonthrone, Armani M Hawes, Monika Karmakar, Lynn M Frydrych, Sandro K Cinti, Rodica Pop-Busui, Matthew J Delano
Introduction Osteomyelitis is associated with significant morbidity, including amputation. There are limited data on long-term amputation rates following an osteomyelitis diagnosis. We sought to determine the incidence of amputation in patients with osteomyelitis over 2 years. Research design and methods Observational cohort study of 1186 inpatients with osteomyelitis between 2004 and 2015 and stratified
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Medical expenditure trajectory and HbA1c progression prior to and after clinical diagnosis of type 2 diabetes in a commercially insured population in the USA BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2023-11-01 Lorissa Pagán, Wenya Yang, Hui Shao, Yu Wang, Ping Zhang
Introduction Medical expenditures of individuals with type 2 diabetes escalate before clinical diagnosis. How increases in medical expenditures are related to glucose levels remains unclear. We examined changes in HbA1c and medical expenditures in years prior to and shortly after type 2 diabetes diagnosis. Research design and methods Using insurance claims and laboratory test results from a commercially
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Responses to the Strengths and Difficulties Questionnaire predict HbA1c trajectories in children and adolescents with type 1 diabetes: a population-based study BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2023-11-01 Kevin P Marks, Frans Pouwer, Morten B Jensen, Else H Ibfelt, Lene J Kristensen, Mikael Thastum, Niels H Birkebæk
Introduction We aimed to determine whether caregiver responses to the Strengths and Difficulties Questionnaire (SDQ) are predictive of HbA1c trajectory membership in children and adolescents with type 1 diabetes, when adjusting for covariates. Research design and methods For a Danish 2009 national cohort of children and adolescents with type 1 diabetes, we analyzed yearly HbA1c follow-up data during
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Prescribing of evidence-based diabetes pharmacotherapy in patients with metabolic dysfunction-associated steatohepatitis BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2023-11-01 Anastasia-Stefania Alexopoulos, Alice Parish, Maren Olsen, Bryan C Batch, Cynthia Moylan, Matthew J Crowley
Introduction Metabolic dysfunction-associated steatohepatitis (MASH) is highly prevalent in type 2 diabetes (T2D). Pioglitazone and glucagon-like peptide-1 receptor agonists (GLP-1RA) are medications used in T2D that can resolve MASH and should be considered in all patients with T2D and MASH. We assessed prescription rates of evidence-based T2D pharmacotherapy (EBP) in MASH, and ascertained racial/ethnic
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Genetic variant rs9939609 in FTO is associated with body composition and obesity risk in Korean females BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2023-11-01 Hyeon-Gyo Park, Jeong-Hwa Choi
Introduction The fat mass and obesity-associated ( FTO ) gene is a significant locus in obesity. However, the association between FTO genetic variants and body composition has not been fully elucidated. Research design and methods This observational study examined the associations of FTO rs9939609 T>A with obesity and body composition markers in Koreans. A total of 6474 participants from the Korean
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Is the 10 g monofilament fit for purpose for diagnosing DPN? BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2023-11-01 Rayaz A Malik
Diabetic peripheral neuropathy (DPN) is causal in the development of foot ulceration and amputation.1 Most guidelines recommend easy-to-use chairside tests such as the 10 g monofilament and neurological examination to assess light touch, proprioception and ankle reflexes for the diagnosis of DPN.2 The 10 g monofilament evaluates large nerve fibers and identifies those with advanced DPN at high risk
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Diagnostic accuracy of the 5.07 monofilament test for diabetes polyneuropathy: influence of age, sex, neuropathic pain and neuropathy severity BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2023-11-01 Øystein Dunker, Martin Uglem, Marie Bu Kvaløy, Sissel Løseth, Ina Elen Hjelland, Sara Maria Allen, Maria Dehli Vigeland, Inge Petter Kleggetveit, Trond Sand, Kristian Bernhard Nilsen
Introduction There is a need for simple and cheap diagnostic tools for diabetic polyneuropathy (DPN). We aimed to assess the diagnostic accuracy of the 5.07/10 g monofilament test in patients referred to polyneuropathy assessments, as well as to examine how disease severity, age, sex and neuropathic pain (NP) impact diagnostic accuracy. Research design and methods Five Norwegian university hospitals
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Unraveling shared risk factors for diabetic foot ulcer: a comprehensive Mendelian randomization analysis BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2023-11-01 Kangli Yin, Tianci Qiao, Yongkang Zhang, Jiarui Liu, Yuzhen Wang, Fei Qi, Junlin Deng, Cheng Zhao, Yongcheng Xu, Yemin Cao
Introduction Diabetic foot ulcer (DFU) stands as a severe diabetic lower extremity complication, characterized by high amputation rates, mortality, and economic burden. We propose using Mendelian randomization studies to explore shared and distinct risk factors for diabetic lower extremity complications. Research design and methods We selected uncorrelated genetic variants associated with 85 phenotypes
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Influence of depression on racial and ethnic disparities in diabetes control BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2023-11-01 Jessica Y Breland, Chi-Hong Tseng, Joy Toyama, Donna L Washington
Introduction We tested the hypotheses that depression diagnoses influence racial and ethnic disparities in diabetes control and that mental health treatment moderates that relationship. Research design and methods We created a national cohort of Veterans Health Administration (VHA) patients with diabetes using administrative data (n=815 067). Cross-sectional linear mixed effects regression models tested
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Patient-reported outcome measures in diabetes outpatient care: a scoping review BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2023-11-01 Astrid Torbjørnsen, Annesofie Lunde Jensen, Tone Singstad, Nina Mickelson Weldingh, Heidi Holmen
Background Patient-reported outcome (PRO) measures are increasingly used in clinical diabetes care to increase patient involvement and improve healthcare services. The objectives were to identify instruments used to measure PROs in outpatient diabetes clinics and to investigate the use of these PRO measures alongside the experiences of patients and healthcare personnel in a clinical setting. Research
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Awareness and knowledge of diabetic ketoacidosis in people with type 1 diabetes: a cross-sectional, multicenter survey BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2023-11-01 Matthias Hepprich, Pia Roser, Sebastian Stiebitz, Barbara Felix, Bernd Schultes, Daniela Schmitz, Jonas Rutishauser, Sabine Schubert, Jens Aberle, Gottfried Rudofsky
Introduction To evaluate awareness and knowledge of diabetic ketoacidosis (DKA), a common and potentially life-threatening complication in people living with type 1 diabetes (T1D). Research design and methods A survey was developed to assess individuals’ current knowledge, management, and unmet needs regarding DKA. The study was conducted in six Swiss and three German endocrine outpatient clinics specialized
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Ethnic disparities in progression rates for sight-threatening diabetic retinopathy in diabetic eye screening: a population-based retrospective cohort study BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2023-11-01 Abraham Olvera-Barrios, Christopher G Owen, John Anderson, Alasdair N Warwick, Ryan Chambers, Louis Bolter, Yue Wu, Roshan Welikala, Jiri Fajtl, Sarah A Barman, Paolo Remagnino, Emily Y Chew, Frederick L Ferris, Aroon D Hingorani, Reecha Sofat, Aaron Y Lee, Catherine Egan, Adnan Tufail, Alicja R Rudnicka
Introduction The English Diabetic Eye Screening Programme (DESP) offers people living with diabetes (PLD) annual eye screening. We examined incidence and determinants of sight-threatening diabetic retinopathy (STDR) in a sociodemographically diverse multi-ethnic population. Research design and methods North East London DESP cohort data (January 2012 to December 2021) with 137 591 PLD with no retinopathy
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Dipeptidyl peptidase-4 inhibitors and the risk of skin cancer among patients with type 2 diabetes: a UK population-based cohort study BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2023-11-01 Richeek Pradhan, Oriana H Y Yu, Robert W Platt, Laurent Azoulay
Introduction The dipeptidyl peptidase-4 (DPP-4) enzyme significantly influences carcinogenic pathways in the skin. The objective of this study was to determine whether DPP-4 inhibitors are associated with the incidence of melanoma and nonmelanoma skin cancer, compared with sulfonylureas. Research design and methods Using the United Kingdom Clinical Practice Research Datalink, we assembled two new-user
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Euglycemic diabetic ketoacidosis in the era of SGLT-2 inhibitors BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2023-10-01 Erica Chow, Stephen Clement, Rajesh Garg
Euglycemic diabetic ketoacidosis (EDKA) is an emerging complication of diabetes associated with an increasing use of sodium-glucose transporter type 2 (SGLT-2) inhibitor drugs. This review highlights the growing incidence of EDKA and its diagnostic challenges due to the absence of hallmark hyperglycemia seen in diabetic ketoacidosis (DKA). The paper presents a classification system for the severity
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PM2.5 exposure, glycemic markers and incidence of type 2 diabetes in two large Indian cities BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2023-10-01 Siddhartha Mandal, Suganthi Jaganathan, Dimple Kondal, Joel D Schwartz, Nikhil Tandon, Viswanathan Mohan, Dorairaj Prabhakaran, K M Venkat Narayan
Introduction Exposure to fine particulate matter has been associated with several cardiovascular and cardiometabolic diseases. However, such evidence mostly originates from low-pollution settings or cross-sectional studies, thus necessitating evidence from regions with high air pollution levels, such as India, where the burden of non-communicable diseases is high. Research design and methods We studied
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Health promotion intervention among women with recent gestational diabetes mellitus: penetration, participation, and baseline findings from the Face-it randomized controlled trial BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2023-10-01 Nanna Husted Jensen, Karoline Kragelund Nielsen, Inger Katrine Dahl-Petersen, Ulla Kampmann, Peter Damm, Per Ovesen, Elisabeth Reinhardt Mathiesen, Christina Anne Vinter, Emma Davidsen, Maja Thøgersen, Anne Timm, Lise Lotte Torvin Andersen, Sine Knorr, Dorte Møller Jensen, Helle Terkildsen Maindal
Introduction Face-it is a randomized controlled trial for women with recent gestational diabetes mellitus (GDM) and their families designed to evaluate the effect of a health promotion intervention on type 2 diabetes mellitus (T2DM) risk and quality of life. This study examined (1) the penetration and participation rates for the Face-it trial, (2) the characteristics of the participating women and
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Anthropometric and DXA-derived measures of body composition in relation to pre-diabetes among adults BMJ Open Diabetes Res. Care (IF 4.1) Pub Date : 2023-10-01 Anwar Mohammad, Ali H. Ziyab, Talal Mohammad
Introduction Abdominal obesity is the most common risk factor of pre-diabetes and diabetes. Currently, several types of indices are used for the determination of visceral fat-related abdominal obesity. To better understand the effect of the different adiposity indices, we sought to evaluate the association of different adiposity measurements, assessed using dual-energy X-ray absorptiometry (DXA), and