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Identification and functional analysis of circpdlim5a generated from pdlim5a gene splicing in the skeletal muscle of Japanese flounder (Paralichthys olivaceus) Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2024-03-18 Hao Wang, Min Liu, Hengtai Tang, Zhirui Zhang, Haishen Wen, Feng He
Circular RNAs (circRNAs) are non-coding RNAs with endogenous regulatory functions, including regulating skeletal muscle development. However, its role in the development of skeletal muscle in Japanese flounder () is not clear. Therefore we screened a candidate circpdlim5a, which is derived from the gene , from the skeletal muscle transcriptome of Japanese flounder. We characterized circpdlim5a, which
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Structural modeling and gene expression analysis of phosvitinless vitellogenin (vgc) in the Indian freshwater murrel, Channa punctatus (Bloch, 1793) Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2024-03-15 Pooja Vijay, Deepak Panwar, Ritu Narwal, Neeta Sehgal
Vitellogenin (Vg) is a female-specific egg-yolk precursor protein, synthesized in the liver of fish in response to estrogens. In the present study, complete gene of phosvitinless vitellogenin ( was sequenced, its 3D structure was predicted and validated by web-based softwares. The complete nucleotide sequence of was 4126 bp which encodes for 1272 amino acids and showed the presence of three conserved
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A longitudinal study of endocrinology and foraging ecology of subadult gray whales prior to death based on baleen analysis Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2024-03-11 Alejandro Fernández Ajó, Clarissa Teixeira, Daniela M.D. de Mello, Danielle Dillon, James M. Rice, C. Loren Buck, Kathleen E. Hunt, Matthew C. Rogers, Leigh G. Torres
Individual-level assessments of wild animal health, vital rates, and foraging ecology are critical for understanding population-wide impacts of exposure to stressors. Large whales face multiple stressors, including, but not limited to, ocean noise, pollution, and ship strikes. Because baleen is a continuously growing keratinized structure, serial extraction, and quantification of hormones and stable
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Early life nutrient restriction affects hypothalamic-pituitary-interrenal axis gene expression in a diet type-specific manner Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2024-03-08 Alexander M. Shephard, Sarah R. Lagon, Cristina C. Ledón-Rettig
Stressful experiences in early life can alter phenotypic expression later in life. For instance, in vertebrates, early life nutrient restriction can modify later life activity of the hypothalamic–pituitary–adrenal/interrenal axis (the HPI in amphibians), including the up- and downstream regulatory components of glucocorticoid signaling. Early life nutrient restriction can also influence later life
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The effect of gonadal hormones on the gene expression of brain-pituitary in protandrous black porgy, Acanthopagrus schlegelii Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2024-03-02 Peng-Wei Tseng, Chien-Ju Lin, Yuan-Han Tsao, Wei-Lun Kuo, Hsin-Chih Chen, Sylvie Dufour, Guan-Chung Wu, Ching-Fong Chang
In black porgy (), the brain-pituitary-testis (Gnrh-Gths-Dmrt1) axis plays a vital role in male fate determination and maintenance, and then inhibiting female development in further (puberty). However, the feedback of gonadal hormones on regulating brain signaling remains unclear. In this study, we conducted short-term sex steroid treatment and surgery of gonadectomy to evaluate the feedback regulation
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The role of multiple vitellogenins in early development of fishes Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2024-02-29 Ozlem Yilmaz, Craig V. Sullivan, Julien Bobe, Birgitta Norberg
Functions of vitellogenins have been in the limelight of fish reproductive physiology research for decades. The Vtg system of acanthomorph teleosts consists of two complete forms of Vtgs (VtgAa and VtgAb) and an incomplete form, VtgC. Insufficient uptake and processing of Vtgs and their yolk proteins lead to inadequate oocyte hydration ensuing failure in acquisition of egg buoyancy and early developmental
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Loss of function in somatostatin receptor 5 has no impact on the growth of medaka fish due to compensation by the other paralogs Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2024-02-25 A.F. Boan, T.H. Delgadin, L.F. Canosa, J.I. Fernandino
Somatic growth in vertebrates is regulated endocrinologically by the somatotropic axis, headed by the growth hormone (GH) and the insulin growth factor-I (IGF-I). Somatostatin (Sst), a peptide hormone synthesized in the hypothalamus, modulates GH actions through its receptors (Sstr). Four Sstr subtypes (Sstr 1–3 and 5) have been identified in teleosts. However, little is known about whether they have
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Evaluation of fish pituitary spheroids to study annual endocrine reproductive control Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2024-02-24 A, k, i, h, i, k, o, , Y, a, m, a, g, u, c, h, i
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SDF-1/CXCR4 signal is involved in the induction of Primordial Germ Cell migration in a model marine fish, Japanese anchovy (Engraulis japonicus) Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2024-02-24 Issei Yahiro, Oga Sato, Sipra Mohapatra, Koki Mukai, Atsushi Toyoda, Takehiko Itoh, Michiya Matsuyama, Tapas Chakraborty, Kohei Ohta
Primordial germ cells (PGCs) are pivotal for gonadal development and reproductive success. Though artificial induction of sterility by targeting PGCs are gaining popularity due to its advantages in fish surrogacy and biodiversity management, it is often skill and time intensive. In this study, we have focused on understanding the role of PGCs and the chemotactic SDF-1/CXCR4 signaling on gonad development
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Effects of neuropeptide Y on the immune-protection and intestinal tract of juvenile Micropterus salmoides Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2024-02-23 Tao Yang, Kingwai Lai, Yang Yu, Zongzhen Liao, Ran Cai, Xiaozheng Yu, Wensheng Li
Neuropeptide Y is known to be directly or indirectly involved in immune regulation. The immune effects of NPY include immune cell transport, helper T cell differentiation, cytokine secretion, staining and killer cell activity, phagocytosis and production of reactive oxygen species. In this study, we investigated the immunoprotective effect of synthetic NPY on largemouth bass larvae. For the first time
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Gonadotropin-inhibitory hormone and its receptors in teleosts: Physiological roles and mechanisms of actions Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2024-02-20 Bin Wang, José A. Paullada-Salmerón, José A. Muñoz-Cueto
Gonadotropin-inhibitory hormone (GnIH) was the first reported hypothalamic neuropeptide inhibiting reproduction in vertebrates. Since its discovery in the quail brain, its orthologs have been identified in a variety of vertebrate species and even protochordates. Depending on the species, the GnIH precursor polypeptides comprise two, three or four mature peptides of the RFamide family. It has been well
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Effects of ghrelin on food caching behaviour and body composition in black-capped chickadees (Poecile atricapillus) Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2024-02-19 Matthew Williamson, Sara Lupi, Scott A. MacDougall-Shackleton
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The influence of selected factors on wool cortisol concentration in alpacas (Vicugna pacos) Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2024-02-17 Joanna Kapustka, Monika Budzyńska, Patrycja Staniszewska, Aneta Strachecka, Adam Staniszewski, Justyna Wojtaś
Several internal and external factors can influence animals’ hormonal activity. Cortisol level in hair and wool determines chronic stress, which is connected with the long-term HPA axis effect. Wool cortisol levels in alpacas have never been determined to this time. The study aimed to assess the influence of selected factors on wool cortisol concentration in alpacas. The study included 36 alpacas.
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Mechanistic study of transcription factor Sox18 during heart development Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2024-02-17 Jianxin Liang, Imtiaz Ul Hassan, Man Yee Cheung, Lei Feng, Yi-jyun Lin, Qi Long, Chengdong Wang, Yuyue Ding, Ziqing Wang, Yuan Zhang, Yulong Li, Donghao Guo, Xiaofang Guo, Thomas Chi Bun Wong, Muhammad Kaleem Samma, Zixin Rong, Xufeng Qi, Dongqing Cai, Sai-Ming Ngai, Hui Zhao
Heart development is a delicate and complex process regulated by coordination of various signaling pathways. In this study, we investigated the role of in heart development by modulating Wnt/β-Catenin signaling pathways. Our spatiotemporal expression analysis revealed that is mainly expressed in the heart, branchial arch, pharyngeal arch, spinal cord, and intersegmental vessels at the tailbud stage
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Extreme olfactory sensitivity of silver and bighead carp to overlapping suites of 21-carbon steroids suggests that these species, and likely all other Cyprinoidei, employ them as pheromones Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2024-02-17 Peter W. Sorensen, Hangkyo Lim
Although well established that several fishes including goldfish in the suborder Cypinoidei within the family Cypriniformes use the maturation-inducing steroid 17,20β-dihydroxy-pregn-4-ene-3-one (17,20βP) and its metabolites as a priming pheromone which they detect with sensitivity and specificity, it is unclear whether and how other Cypriniformes might have evolved to do so. This study examined this
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RNA-Seq analysis offers insight into the TBBPA-DHEE-induced endocrine-disrupting effect and neurotoxicity in juvenile zebrafish (Danio rerio) Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2024-02-14 Emmanuel Sunday Okeke, Weiwei Feng, Mengna Luo, Guanghua Mao, Yao Chen, Ting Zhao, Xiangyang Wu, Liuqing Yang
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The chondrichthyan glucagon-like peptide 3 regulates hepatic ketone metabolism in the Pacific spiny dogfish Squalus suckleyi Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2024-02-10 Alyssa M Weinrauch, Ian A Bouyoucos, J Michael Conlon, W Gary Anderson
Chondrichthyans have a novel proglucagon-derived peptide, glucagon-like peptide (GLP)-3, in addition to GLP-1 and GLP-2 that occur in other vertebrates. Given that the GLPs are important regulators of metabolic homeostasis across vertebrates, we sought to investigate whether GLP-3 displays functional actions on metabolism within a representative chondrichthyan, the Pacific spiny dogfish There were
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Coping with extreme free cortisol levels: Seasonal stress axis changes in sympatric North American flying squirrels Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2024-02-09 Samantha M. Stead, Phoebe D. Edwards, Rebekah Persad, Rudy Boonstra, Julie A. Teichroeb, Rupert Palme, Jeff Bowman
Most environments exhibit predictable yearly changes, permitting animals to anticipate them. The hypothalamic–pituitary–adrenal (HPA) axis is a key physiological pathway that enables animals to cope with such changes. Monitoring glucocorticoid (the end products of the HPA axis) levels in wild animals throughout the year can improve our understanding of how this pathway responds to different conditions
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Gonadotropin expression, pituitary and plasma levels in the reproductive cycle of wild and captive-reared greater amberjack (Seriola dumerili) Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2024-02-08 Ioannis Fakriadis, Iris Meiri-Ashkenazi, Chen Bracha, Hanna Rosenfeld, Aldo Corriero, Rosa Zupa, Chrysovalentinos Pousis, Maria Papadaki, Constantinos C. Mylonas
We compared the endocrine status of the pituitary-gonad axis of wild and captive-reared greater amberjack () during the reproductive cycle (April – July), reporting on the expression and release of the two gonadotropins for the first time in the Mediterranean Sea. Ovaries from wild females were characterized histologically as DEVELOPING in early May and SPAWNING capable in late May-July, the latter
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Adiponectin and visfatin expression profile in extra-embryonic annexes and role during embryo development in layer and broiler chickens Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2024-02-06 Ophélie Bernardi, Christelle Ramé, Maxime Reverchon, Joëlle Dupont
Some evidence showed differences between layer and broiler embryo development. We recently showed that two adipokines, adiponectin and visfatin are expressed in the extra embryonic membranes and fluids. However, their role in the embryo development is unknown. Thus, our objectives were 1. to compare the expression of AdipoQ and its receptors AdipoR1 and AdipoR2 and visfatin in extra-embryonic annexes
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α1 and β3 adrenergic receptor-mediated excitatory effects of adrenaline on the caudal neurosecretory system (CNSS) in olive flounder, Paralichthys olivaceus Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2024-02-05 Mengmeng Shi, Cheng Liu, Yeyang Qin, Lin Yv, Weiqun Lu
Adrenaline is one of the most important neurotransmitters in the central nervous system and is produced during stress. In this study, we investigated the modulatory role of adrenaline and adrenergic receptors on the neuroendocrine Dahlgren cells in the caudal neurosecretory system (CNSS) of olive flounder. electrophysiological recordings revealed that adrenaline significantly increased the firing frequency
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Characterization of insulin-like growth factor 3 and its potential role in the spotted steed Hemibarbus maculatus ovary development Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2024-02-03 Huifen Liu, Qi Guo, Xinyu Wang, Xiao Ma, Xuejun Li, Xue Tian
As a new member of the insulin-like growth factors (Igfs), Igf3 was reported to play a vital role in fish reproduction. However, in spotted steed, the function of Igf3 remains largely unknown. In the present study, we identified and characterized Igf3 gene in spotted steed. Structural analysis showed that Igf3 contained five domains (B, C, A, D, E) and six conserved cysteine residues. The expression
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Zebrafish prss59.1 is involved in chorion development Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2024-01-27 Md. Rezanujjaman, Theeranukul Pachoensuk, Md. Forhad Hossain, Md. Maisum Sarwar Jyoti, Md. Rubel Rana, Eisei Tsutsumi, Takumi Mouri, Maria Bramastri Susilo, Klangnurak Wanlada, Chihiro Yamamoto, Md. Hasan Ali, Toshinobu Tokumoto
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Resistin in endocrine pancreas of sheep: Presence and expression related to different diets Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2024-01-19 Margherita Maranesi, Elisa Palmioli, Cecilia Dall'Aglio, Daniele Marini, Polina Anipchenko, Elena De Felice, Paola Scocco, Francesca Mercati
Resistin (RETN), a recently discovered adipokine, is a cysteine-rich and secretory protein produced by adipocytes. RETN has been detected in several tissues, including human and laboratory animals' pancreas, wherein impairs glucose tolerance and insulin (INS) action and causes INS resistance. This study aims to evaluate the presence and expression of RETN in the pancreas of 15 adult female sheep reared
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Investigations of the function of AMH in granulosa cells in hens Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2024-01-22 Laurie Francoeur, Deena M. Scoville, Patricia A. Johnson
Anti-mullerian hormone (AMH) plays a crucial role in follicle regulation in mammals by preventing premature primordial follicle activation and restricting follicle development through reduction of FSH sensitivity and inhibition of FSH-induced increase of steroidogenic enzymes. AMH is produced by granulosa cells from growing follicles and expression declines at the time of selection in both mammalian
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Heterogeneity in the preferential diet of neotropical bats impacts the pancreatic islet mass and α and β cell distribution Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2024-01-10 M. Contini, G.D. Cruz, S.F. Althoff, M.B. Freitas, S.R. Taboga, A. Rafacho
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Testosterone regulates thymic remodeling by altering metabolic reprogramming in male rats Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2024-01-06 Dong Li, Huan Yao, Yonghao Ren, Jiameng Shang, Xinfa Han, Xiaohan Cao, Tianzeng Song, Xianyin Zeng
The thymus is an energy-consuming organ, and its metabolism changes with atrophy. Testosterone regulates thymus remodeling (atrophy and regeneration). However, the characteristics of the energy metabolism during testosterone-mediated thymic atrophy and regeneration remain unclear. In this study, we demonstrated that testosterone ablation (implemented by immunocastration and surgical castration) induced
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Effects of different hormonal treatments on spermatogenesis advancement in hatchery-produced greater amberjack Seriola dumerili (Risso 1810) Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2024-01-11 G. Ventriglia, I. Fakriadis, M. Papadaki, R. Zupa, C. Pousis, M. Mandalakis, A. Corriero, C.C. Mylonas
In earlier studies, wild-caught greater amberjack Seriola dumerili (Risso, 1810) males reared in sea cages showed gametogenesis impairment and low sperm production and quality. Here, we (a) examined if F1 hatchery-produced males reared in sea cages also exhibit reproductive dysfunctions and (b) evaluated the effects of gonadotropin releasing hormone agonist (GnRHa) administration through injections
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Extraembryonic metabolism of corticosterone protects against effects of exposure Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-12-27 Emily P. Harders, Christina Charboneau, Ryan T. Paitz
When females experience stress during reproduction, developing embryos can be exposed to elevated levels of glucocorticoids, which can permanently affect offspring development, physiology, and behavior. However, the embryo can regulate exposure to glucocorticoids. In placental species, the placenta regulates embryonic exposure to maternal steroids via metabolism. In a comparable way, recent evidence
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Defining components of early thyroid hormone signalling through temperature-mediated activation of molecular memory in cultured Rana [lithobates] catesbeiana tadpole back skin Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-12-29 E.P. Evans, C.C. Helbing
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Unraveling the G protein-coupled receptor superfamily in aphids: Contractions and duplications linked to phloem feeding Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-12-20 Han Gao, Yanxiao Li, Xianzhen Zhang, Hui Zhang, Ying Tian, Bin Li
The G Protein-Coupled Receptor (GPCR) superfamily is the largest and most diverse transmembrane receptor family, playing crucial roles in regulating various physiological processes. As one of the most destructive pests, aphids have been subject to previous studies, which revealed fewer GPCR superfamily members in Acyrthosiphon pisum and Aphis gossypii and the loss of multiple neuropeptide GPCRs. To
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Hypothalamic-pituitary-gonadal axis response to photoperiod changes in female guanacos (Lama guanicoe) Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-12-22 Lina Maria Correa, Ricardo D. Moreno, José Luis Riveros
The guanaco, a wild South American camelid, is renowned for its remarkable resilience to extreme conditions. Despite this, little is known about how reproductive hormones in female camelids are influenced during their seasonal breeding period, which occurs during long photoperiod. To explore this, the study investigated the response of the hypothalamic-pituitary–gonadal axis in female guanacos during
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Effect of prolonged feeding of broodstock diet with increased inclusion of essential n-3 fatty acids on maturing and spawning performance in 3-year-old Atlantic salmon (Salmo salar) Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-12-22 André S. Bogevik, Aleksei Krasnov, Erik Burgerhout, Kjetil Berge, Ida Martinsen, Eirik Hoel, Lars Erik Dalva, Sigurd Kilane, Jon Eriksen Vold, Bjarne Aarhus, Tone-Kari K. Østbye, Grethe Rosenlund, Thea Morken
Atlantic salmon (Salmo salar) broodstock recruits are normally fed a specialized diet with a higher content of essential nutrients for a limited time period prior to fasting and transfer to freshwater. Typically, this period lasts for about six months, but may vary among producers. Reduced use of marine ingredients in commercial salmon diets during the last decades has affected the content of essential
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A phylogenetics-based nomenclature system for steroid receptors in teleost fishes Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-12-21 Kathleen M. Munley, Andrew P. Hoadley, Beau A. Alward
Teleost fishes have emerged as tractable models for studying the neuroendocrine regulation of social behavior via molecular genetic techniques, such as CRISPR/Cas9 gene editing. Moreover, teleosts provide an opportunity to investigate the evolution of steroid receptors and their functions, as species within this lineage possess novel steroid receptor paralogs that resulted from a teleost-specific whole
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Endocrine patterns associated with ovarian development in female Pacific halibut (Hippoglossus stenolepis) Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-12-14 Crystal Simchick, Kennedy Bolstad, Anna Simeon, Josep V. Planas
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FGFs function in regulating myoblasts differentiation in spotted sea bass (Lateolabrax maculatus) Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-12-14 Jing Yang, Ximeng Dong, Haishen Wen, Yun Li, Xiaojie Wang, Shaojing Yan, Chenpeng Zuo, Likang Lyu, Kaiqiang Zhang, Xin Qi
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Estrogen regulated transcription of the non-estrogen-regulated hamster uteroglobin gene in MCF-7 cells Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-12-13 Edith Cruz-Huerta, Teresa Zariñán, Juana Enríquez, Alfredo Ulloa-Aguirre, Rubén Gutiérrez-Sagal
To study the estrogen regulated transcription of the uteroglobin (UG) gene, the founding member of the secretoglobin family widely expressed in many different mammalian species, we re-created functional estrogen response elements (EREs) in the UG gene promoter from a species where UG expression is not regulated by estrogens: the hamster Mesocricetus auratus (Ma), to ascertain if the lack of functional
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Cloning, phylogenetic and expression analysis of two MyoDs in yellowtail kingfish (Seriola lalandi) Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-12-12 Bao Shi, Ranran Sun, Xuezhou Liu, Yongjiang Xu, Yan Jiang, Kewen Yan, Yan Chen
Yellowtail kingfish (Seriola lalandi) is a pelagic piscivore distributed circumglobally. Owing to its great market value, the growth mechanism of S. lalandi, including muscle development and growth, is a hot research topic. The myoblast determination protein (MyoD) gene has been shown to play an important role in formation of myoblasts and the function of somites in fish. The open reading frame (ORF)
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Characterization of eight types of 17β-hydroxysteroid dehydrogenases from the Japanese sardine Sardinops melanostictus: The probable role of type 12a in ovarian estradiol synthesis Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-12-10 Mitsuo Nyuji, Yuki Hongo, Yukinori Kazeto, Michio Yoneda
17β-hydroxysteroid dehydrogenases (Hsd17bs) play a critical role in sex steroid biosynthesis. Although multiple types of Hsd17b have been found in fish, there is limited research on their expression and function. Recently, we succeeded in identifying eight types of Hsd17b (types 3, 4, 7, 8, 10, 12a, 12b, and 14) by RNA sequencing in the Japanese sardine Sardinops melanostictus, a commercially important
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Effects of cooling on thyroid hormone secretion and growth of eastern bluebird (Sialia sialis) nestlings Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-12-09 Sharon E. Lynn, Michael D. Kern, Nathan Cagwin, Alexis Will, Alexander Kitaysky
Achieving endothermic homeothermy is a critical aspect of avian development. In pre-homeothermic altricial nestlings, variation in parental brooding behavior results in variable exposure of nestlings to cooling, with consequences for the developing endocrine system. Nestlings facing repeated cooling challenges may benefit from upregulation of thyroid hormone secretion, allowing for earlier onset of
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Incubation as a driver of maternal effects: Temperature influences levels of yolk maternally derived 5α-dihydrotestosterone Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-12-04 América Hernández, Roxana Torres, Bibiana Montoya
In birds, maternal hormones deposited into eggs in response to environmental stimuli can impact offspring phenotype. Although less studied, environmental conditions can also influence females’ incubation behavior, which might play a role in regulating embryo exposure to maternal hormones through changes in incubation temperature that affect the activity of the enzymes responsible for converting testosterone
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Effects of testosterone on urogenital tract morphology and androgen receptor expression in immature Eastern Fence lizards (Sceloporus undulatus) Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-11-28 Matthew R. Milnes, Christopher D. Robinson, Alexis P. Foley, Charleigh Stepp, Matthew D. Hale, Henry B. John-Alder, Robert M. Cox
In non-avian reptiles, the onset of sexual dimorphism of the major structures of the urogenital tract varies temporally relative to gonadal differentiation, more so than in other amniote lineages. In the current study, we used tonic-release implants to investigate the effects of exogenous testosterone (T) on postnatal development of the urogenital tract in juvenile Eastern Fence Lizards (Sceloporus
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Structural and functional characterization of an egg-laying hormone signaling system in a lophotrochozoan – The pacific oyster (Crassostrea gigas) Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-11-28 P. Favrel, M.P. Dubos, B. Bernay, J. Pasquier, J. Schwartz, B. Lefranc, L. Mouret, G. Rivière, J. Leprince, A. Bondon
The egg-laying hormones (ELHs) of gastropod mollusks were characterized more than forty years ago. Yet, they have remained little explored in other mollusks. To gain insights into the functionality of the ELH signaling system in a bivalve mollusk – the oyster Crassostrea gigas, this study investigates the processing of its ELH precursor (Cragi-ELH) by mass spectrometry. Some of the ELH mature peptides
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Influence of EE2 exposure, age and sex on telomere length in European long-snouted seahorse (Hippocampus guttulatus) Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-11-30 Nathalie Prévot D'Alvise, Eliette Ascensio, Simone Richard
After a Telomere Lengthening in juvenile stage, a progressive telomere shortening occurs with age despite higher telomerase level. Telomere Length (TL) may also reflect past physiological state such as a chronic chemical stress. Several studies have revealed a correlation between TL, ageing and/or sex in vertebrates, including teleosts; however, the patterns of telomere dynamics with telomerase mRNA
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Timing of puberty in F1-generation hatchery-produced greater amberjack (Seriola dumerili) Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-11-24 Stefano Lancerotto, Ioannis Fakriadis, Maria Papadaki, Manolis Mandalakis, Irini Sigelaki, Constantinos C. Mylonas
We evaluated the onset of puberty of first-generation (F1) hatchery-produced greater amberjack (Seriola dumerili) reared in sea cages for 5 years. Fish were sampled every year in June, at the expected peak of the spawning period in the Mediterranean Sea. No sexual dimorphism in body weight was observed in the study. The ovaries of 1 and 2-year-old (yo) females consisted of primary oocytes only, while
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Molecular form identification of anterior pituitary gland-secreted prolactin in chicken Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-11-22 Norio Kansaku, Takeshi Ohkubo
Endocrine changes during bird reproduction are well documented. Prolactin (PRL) exhibits a strong relationship between incubation and broody behavior. The molecular forms of PRL in the anterior pituitary gland during the reproductive cycle have already been previously identified but not those in the secreted form. To identify the molecular forms of secreted PRL during the reproductive cycle, we thus
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Water-borne testosterone levels predict exploratory tendency in male poison frogs Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-11-22 Eva Ringler, Katharina Dellefont, Mélissa Peignier, Virginie Canoine
Hormones play a fundamental role in mediating social behaviors of animals. However, it is less well understood to what extent behavioral variation between individuals can be attributed to variation in underlying hormonal profiles. The goal of the present study was to infer if individual androgen levels, and/or the modulation thereof, can explain among-individual variation in aggressiveness, boldness
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Food deprivation reduces sensitivity of liver Igf1 synthesis pathways to growth hormone in juvenile gopher rockfish (Sebastes carnatus) Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-11-06 Theresa V. Bersin, Kasey L. Cordova, Meredith L. Journey, Brian R. Beckman, Sean C. Lema
Growth hormone (Gh) regulates growth in part by stimulating the liver to synthesize and release insulin-like growth factor-1 (Igf1), which then promotes somatic growth. However, for fish experiencing food limitation, elevated blood Gh can occur even with low circulating Igf1 and slow growth, suggesting that nutritional stress can alter the sensitivity of liver Igf1 synthesis pathways to Gh. Here, we
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Molecular cloning of estrogen receptor and its function on vitellogenesis in pompano (Trachinotus ovatus) Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-11-02 Xiaomeng Li, Charles Brighton Ndandala, Qi Zhou, Chunyan Huang, Guangli Li, Huapu Chen
Estrogen receptors (ERs) play a critical role in vitellogenesis (Vtgs). However, the contribution of each ER for the regulation of vtgs expression was not analyzed clearly in teleosts. In the present study, three ers isoforms (erα, erβ1, and erβ2) were cloned in pompano (Trachinotus ovatus). Real-time PCR and enzyme-linked immunosorbent assay (ELISA) was used to detect the effects of 17β-estradiol
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Transcriptional regulation of IAG by dsx and foxl-2 in mud crab (Scylla paramamosain) Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-10-23 Jiaqian Liao, Haifu Wan, Ziping Zhang, Yinshen Sheng, Xiwei Jia, Yilei Wang
Scylla paramamosain is an important cultured crab species on the southeast coast of China. However, the molecular regulation mechanism of its gonadal development still has not been thoroughly studied. Dsx (doublesex) and foxl-2 (forkhead transcription factor gene 2) are important transcription factors involved in gonadal development. So far, studies on the functions of dsx and foxl-2 in crustaceans
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Tilapia, a good model for studying reproductive endocrinology Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-10-23 Minghui Li, Lina Sun, Linyan Zhou, Deshou Wang
The Nile tilapia (Oreochromis niloticus), with a system of XX/XY sex determination, is a worldwide farmed fish with a shorter sexual maturation time than that of most cultured fish. Tilapia show a spawning cycle of approximately 14 days and can be artificially propagated in the laboratory all year round to obtain genetically all female (XX) and all male (XY) fry. Its genome sequence has been opened
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Authentication of a lophotrochozoan adipokinetic hormone receptor in a Gastropod, Aplysia californica Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-10-20 Pei-San Tsai, Kelsey N. Sanders, Xin Dai, David Plachetzki
Gonadotropin-releasing hormone (GnRH) superfamily comprises multiple families of signaling peptides in both protostomes and deuterostomes. Among this superfamily, vertebrate GnRH stimulates reproduction, but other GnRH superfamily members elicit diverse pleiotropic effects. Within the GnRH superfamily members, adipokinetic hormone (AKH) and its receptor are well described in ecdysozoans but understudied
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COVID-19 as a chronic stressor and the importance of individual identity: A data-driven look at academic productivity during the pandemic Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-10-21 Breanna N. Harris, Carolyn M. Bauer, James A. Carr, Caitlin R. Gabor, Jennifer L. Grindstaff, Caleigh Guoynes, Jennifer J. Heppner, Cris C. Ledon-Rettig, Patricia C. Lopes, Sharon E. Lynn, Carla B. Madelaire, Lorin A. Neuman-Lee, Maria G. Palacios, Paul Soto, Jennifer Terry
The COVID-19 pandemic impacted personal and professional life. For academics, research, teaching, and service tasks were upended and we all had to navigate the altered landscape. However, some individuals faced a disproportionate burden, particularly academics with minoritized identities or those who were early career, were caregivers, or had intersecting identities. As comparative endocrinologists
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Molecular characterization and ontogenetic expression profiles of LPXRFa and its receptor in Japanese flounder (Paralichthys olivaceus) Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-10-17 Jun Chen, Yuru Li, Wenwen Zhang, Yanqing Wu, Limiao Zhao, Xueying Huang, Yan Fang, Bin Wang
Investigations concerning the LPXRFa system are rarely conducted in flatfish species. Here, we first identified and characterized lpxrfa and its cognate receptor lpxrfa-r genes in the Japanese flounder (Paralichthys olivaceus). The coding DNA sequence of lpxrfa was 579 bp in length, wich encoded a 192-aa preprohormone that can produce three mature LPXRFa peptides. The open reading frame (ORF) of lpxrfa-r
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Male Cope’s gray treefrogs (Hyla chrysoscelis) in amplexus have elevated and correlated steroid hormones compared to solitary males Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-10-14 Alexander T. Baugh
Gonadal steroid hormones are typically elevated during the breeding season—a finding known as an associated reproductive pattern. Though less studied, there is also evidence, in both sexes, for elevated adrenal/interrenal steroids, including acute elevations on the day of mating. I investigated gonadal and interrenal steroids in wild male Cope’s gray treefrogs at breeding aggregations. I collected
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Salivary corticosterone reflects plasmatic levels in a wild seabird Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-10-14 Jeffrey Carbillet, Lauri Saks, Tuul Sepp
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The uterus masculinus of the Eurasian beaver (Castor fever L.) – The appraisal of fast hormone regulation by membrane androgen and estrogen receptors involvement Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-10-04 M. Kotula-Balak, G. Lonc, M. Zarzycka, J. Tomiyasu, K. Knapczyk-Stwora, B.J. Płachno, A.J. Korzekwa, J. Kaczmarczyk, I. Krakowska
The phenomenon of remaining paramesonephric ducts (uterus masculinus) in males of some animal species concerning its role is still an unresolved issue. Now it is well-recognized that sex hormonal regulation of reproductive physiology involves also fast nongenomic control of cellular processes through noncanonical signaling. Herein, in the uterus masculinus of Eurasian beaver membrane androgen receptor
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Changes in hypothalamic–pituitary–adrenal axis function, immunity, and glucose during acute Plasmodium relictum infection in house sparrows (Passer domesticus) Gen. Comp. Endocrinol. (IF 2.7) Pub Date : 2023-10-04 T.R. Kelly, A.L. Cannon, K.R. Stansberry, M.G. Kimball, C.R. Lattin
Hosts of the same species vary in physiological responses to the same parasite, and some groups of individuals can disproportionately affect disease dynamics; however, the underlying pathophysiology of host-parasite interactions is poorly understood in wildlife. We tested the hypothesis that the hypothalamic–pituitary–adrenal (HPA) axis mediates host resistance and tolerance to avian malaria during