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Paternal peri‐conceptional physical activity and the risk of congenital heart disease in offspring: A case–control study Andrology (IF 4.5) Pub Date : 2024-04-12 Ornina Atieh, Nohad Maria J. Azzi, Georges J. Lteif, Ninar A. Atieh, Nadim Y. Germanos, Valérie Grandjean, Zalihe Yarkiner, Zakhia Saliba, Marie‐Claude Fadous Khalife, Georges Raad
BackgroundGenetic and environmental factors have been shown to contribute to the development of congenital heart disease (CHD). To date, the focus of scientific articles has primarily centered on genetics and maternal environmental factors, with comparatively less attention given to paternal risk factors.ObjectivesThis study aims to investigate the potential association between paternal pre‐conceptional
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Excessive androgen exposure and risk of malignancies: A cohort study Andrology (IF 4.5) Pub Date : 2024-04-11 Ida M. Heerfordt, Josefine Windfeld‐Mathiasen, Kim Peder Dalhoff, Jon Trærup Andersen, Henrik Horwitz
BackgroundA link between androgen use and the risk of cancers, especially prostate and breast cancer, has been suggested. The knowledge about a possible association is limited.ObjectiveThe study aimed to investigate cancer incidence rates, particularly those related to prostate and breast cancer, in male androgen users and compare them to a control group.MethodsWe included male androgen users identified
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Prevalence of infertility and barriers to family building among male physicians Andrology (IF 4.5) Pub Date : 2024-04-10 Jasmine S. Lin, Justin M. Dubin, Jonathan Aguiar, Robert E. Brannigan, Joshua A. Halpern
BackgroundFertility declines with increasing age and physicians often delay childbearing beyond prime reproductive years for the sake of medical training. However, the risks of infertility in male physicians compared to the general population remain poorly studied.ObjectivesTo characterize rates of infertility among male physicians and identify barriers in access to fertility care and family building
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Knockout of phosphatidylethanolamine binding protein4 (PEBP4) promotes chronic non‐bacterial prostatitis by mediating the activation of NF‐κB signaling Andrology (IF 4.5) Pub Date : 2024-04-09 Hailan He, Guancheng Xiao, Xing Hu, Hui Luo, Yunfeng Liao, Biao Qian, Guoxi Zhang, Xiaofeng Zou, Junrong Zou
BackgroundThe etiology of chronic prostatitis remains unclear; consequently, this disease is associated with recurrence and ineffective clinical therapy. Therefore, there is an urgent need to investigate the underlying pathogenesis of chronic prostatitis in order to develop more efficacious treatments.ObjectiveThe previous study found that knocking out of PEBP4 leads to chronic prostatitis in the male
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PDE5is‐naïve versus non‐naïve patients at first investigation for erectile dysfunction—findings from a long‐term, real‐life cross‐sectional study Andrology (IF 4.5) Pub Date : 2024-04-08 Simone Cilio, Paolo Capogrosso, Edoardo Pozzi, Federico Belladelli, Christian Corsini, Massimiliano Raffo, Luigi Candela, Giuseppe Fallara, Luca Boeri, Alessia d'Arma, Ciro Imbimbo, Vincenzo Mirone, Francesco Montorsi, Andrea Salonia
BackgroundPhosphodiesterase 5 inhibitors (PDE5is) represent a first‐line pharmacological therapy for erectile dysfunction (ED). Men could obtain PDE5is for recreational purposes without any proper medical prescription.ObjectiveWe aimed to analyze clinical characteristics of patients who already used any PDE5i for ED without previous formal medical prescription.Materials and methodsData from 2012 heterosexual
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Phosphoproteomic analysis of the adaption of epididymal epithelial cells to corticosterone challenge Andrology (IF 4.5) Pub Date : 2024-04-05 David A. Skerrett‐Byrne, Simone J. Stanger, Natalie A. Trigg, Amanda L. Anderson, Petra Sipilä, Ilana R. Bernstein, Tessa Lord, John E. Schjenken, Heather C. Murray, Nicole M. Verrills, Matthew D. Dun, Terence Y. Pang, Brett Nixon
BackgroundThe epididymis has long been of interest owing to its role in promoting the functional maturation of the male germline. More recent evidence has also implicated the epididymis as an important sensory tissue responsible for remodeling of the sperm epigenome, both under physiological conditions and in response to diverse forms of environmental stress. Despite this knowledge, the intricacies
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The human infertility single‐cell testis atlas (HISTA): an interactive molecular scRNA‐Seq reference of the human testis Andrology (IF 4.5) Pub Date : 2024-04-05 Eisa Mahyari, Katinka A. Vigh‐Conrad, Clément Daube, Ana C. Lima, Jingtao Guo, Douglas T. Carrell, James M. Hotaling, Kenneth I. Aston, Donald F. Conrad
BackgroundSingle‐cell RNA‐seq (scRNA‐Seq) has been widely adopted to study gene expression of the human testis. Several datasets of scRNA‐Seq from human testis have been generated from different groups processed with different informatics pipelines. An integrated atlas of scRNA‐Seq expression constructed from multiple donors, developmental ages, and fertility states would be widely useful for the testis
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Testicular sperm retrieval for intracytoplasmic sperm injection: when to consider it after unsuccessful intracytoplasmic sperm injection with ejaculated sperm? Andrology (IF 4.5) Pub Date : 2024-04-02 Muhammed Arif Ibis, Eda Ureyen Ozdemir, Khaled Obaid, Cagri Akpinar, Batuhan Ozmen, Kaan Aydos, Onder Yaman
BackgroundThe question of whether patients are more likely to succeed with testicular sperm intracytoplasmic sperm injection (T‐ICSI) after unsuccessful ICSI with ejaculated sperm (Ej‐ICSI) remains unknown.ObjectiveThe study aimed to identify potential predictors of successful T‐ICSI in men with idiopathic infertility and oligozoospermia (sperm concentration < 15 × 106/mL, non‐azoospermic) who had
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Trans men can achieve adequate muscular development through low‐dose testosterone therapy: A long‐term study on body composition changes Andrology (IF 4.5) Pub Date : 2024-04-02 Yusuke Tominaga, Tomoko Kobayashi, Yuko Matsumoto, Takatoshi Moriwake, Yoshitaka Oshima, Misa Okumura, Satoshi Horii, Takuya Sadahira, Satoshi Katayama, Takehiro Iwata, Shingo Nishimura, Kensuke Bekku, Kohei Edamura, Morito Sugimoto, Yasuyuki Kobayashi, Masami Watanabe, Yuzaburo Namba, Yosuke Matsumoto, Mikiya Nakatsuka, Motoo Araki
BackgroundTransgender individuals undergo the gender‐affirming hormone therapy (GAHT) to achieve physical changes consistent with their gender identity. Few studies are available on the long‐term safety and efficacy of GAHT.ObjectivesTo investigate the long‐term physical effects and the safety of the testosterone therapy for trans men and to assess the impact of differential hormone dose.Materials
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Which PDE5 inhibitor is the most effective in the treatment of erectile dysfunction in men with spinal cord injury? A systematic review and network meta‐analysis Andrology (IF 4.5) Pub Date : 2024-03-30 Daniele Tienforti, Giorgio Felzani, Alfonso Boris Di Pasquale, Arcangelo Barbonetti
BackgroundPhosphodiesterase 5 inhibitors (PDE5i) are the first‐line drugs for erectile dysfunction (ED) but differences among available molecules should drive therapy personalization. Choosing one PDE5i over another is a challenge in men with spinal cord injury (SCI), as the evidence of efficacy for each molecule is derived from few studies and comparative “head‐to‐head” trials are lacking.ObjectiveTo
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Exploring sexual function in adrenal insufficiency: findings from the Dual RElease hydrocortisone versus conventionAl glucocorticoid replaceMent therapy in hypocortisolism (DREAM) trial Andrology (IF 4.5) Pub Date : 2024-03-28 Valeria Hasenmajer, Dario De Alcubierre, Davide Ferrari, Marianna Minnetti, Ilaria Bonaventura, Riccardo Pofi, Chiara Simeoli, Alessandra Tomaselli, Francesca Sciarra, Grazia Bottillo, Francesco Angelini, Alessia Cozzolino, Mary Anna Venneri, Emmanuele A. Jannini, Daniele Gianfrilli, Rosario Pivonello, Andrea M. Isidori
BackgroundData on sexual function in patients with adrenal insufficiency are scarce and largely controversial.ObjectivesTo investigate sexual dysfunction in patients with primary and secondary adrenal insufficiency and the effects of switching to once‐daily dual‐release hydrocortisone on sexual function in outcome assessors blinded, randomized, multicenter, active comparator clinical trial.Materials
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Telomeric function and regulation during male meiosis in mice and humans Andrology (IF 4.5) Pub Date : 2024-03-21 Lisha Yin, Nan Jiang, Tao Li, Youzhi Zhang, Shuiqiao Yuan
BackgroundTelomeres are unique structures situated at the ends of chromosomes. Preserving the structure and function of telomeres is essential for maintaining genomic stability and promoting genetic diversity during male meiosis in mammals.Material‐MethodsThis review compiled recent literature on the function and regulation of telomeres during male meiosis in both mice and humans, and also highlighted
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Correlation between serum tryptophan metabolism and treatment efficacy of dapoxetine in patients with premature ejaculation: A pilot study Andrology (IF 4.5) Pub Date : 2024-03-21 Chenglun Wu, Shengyu Huang, Zhuojie Liu, Yixin Wang, Yuanqiang Zhu, Zhi‐Jun Zang
IntroductionPrimary premature ejaculation (PPE) is a common male neurobiological disorder. Currently, there is consensus that the impairment in central serotonin (5‐HT) neurotransmission constitutes a key pathogenic factor in PPE. Selective serotonin reuptake inhibitors (SSRIs) serve as the primary pharmacological intervention; however, a comprehensive elucidation of their mechanism of action remains
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Leading at the vanguard of andrology: The Network for Young Researchers in Andrology joins forces with the European Academy of Andrology Andrology (IF 4.5) Pub Date : 2024-03-20 Alberto de la Iglesia, Dorte L. Egeberg, Daniel Marcu, Guillaume Richer, Brendan J. Houston, Omar Ammar, Gülizar Saritas, Emily Delgouffe, Davor Jezek, Csilla Krausz, Ewa Rajpert-De Meyts, Hermann M. Behre
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest.
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Integration of hepatitis B virus into patients’ sperm genome and its clinical risks Andrology (IF 4.5) Pub Date : 2024-03-20 Ting‐Ting Han, Ji‐Hua Huang, Ling‐Xiao Li, Xue Liao, Xiang‐Qian Meng, Zi‐Na Wen, Qian Sun, Jian Ma, Tian‐Hua Huang
BackgroundLike the coronavirus disease 2019, the hepatitis B virus is also wreaking havoc worldwide, which has infected over 2 billion people globally. Using an experimental animal model, our previous research observed that the hepatitis B virus genes integrated into human spermatozoa can replicate and express after being transmitted to embryos. However, as of now, this phenomenon has not been confirmed
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Erectile dysfunction criteria of 131,350 patients after open, laparoscopic, and robotic radical prostatectomy Andrology (IF 4.5) Pub Date : 2024-03-20 Tomás Bernardo Costa Moretti, Luís Alberto Magna, Leonardo Oliveira Reis
PurposeComparing post‐radical prostatectomy erectile function rates among different techniques has always been a challenge in urology. This difficulty is due to the heterogeneity of studies, mainly in relation to the type of erectile function classification criteria used. The aim is to apply a new evidence‐gathering methodology, called reverse systematic review, to compare erectile function rates among
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A Mendelian randomization study on causal effects of leisure sedentary behavior on the risk of erectile dysfunction Andrology (IF 4.5) Pub Date : 2024-03-20 Zhao Huangfu, Xinxin Gan, Yiren Yang, Qingyang Pang, Baohua Zhu, Xiao Zhang, Linhui Wang
BackgroundErectile dysfunction has been associated with leisure sedentary behavior in several epidemiological and observational studies. However, the interpretation of these findings is difficult due to residual confounding or reverse causality.ObjectivesTo explore the causal association between leisure sedentary behavior and erectile dysfunction, and to explore the underlying mechanism using Mendelian
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Regional modulation of toll‐like receptor signaling pathway genes in acute epididymitis in mice Andrology (IF 4.5) Pub Date : 2024-03-18 Alexandre D. Andrade, Priscila G. C. Almeida, Noemia A. P. Mariani, Natalia C. M. Santos, Isabela A. Camargo, Poliana V. Martini, Helio Kushima, Dingding Ai, Maria Christina W. Avellar, Andreas Meinhardt, Christiane Pleuger, Erick J. R. Silva
BackgroundRegion‐specific immune environments in the epididymis influence the immune responses to uropathogenic Escherichia coli (UPEC) infection, a relevant cause of epididymitis in men. Toll‐like receptors (TLRs) are essential to orchestrate immune responses against bacterial infections. The epididymis displays region‐specific inflammatory responses to bacterial‐derived TLR agonists, such as lipopolysaccharide
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Testosterone therapy in men with classical versus functional hypogonadism: results from a controlled 9‐years, real‐world registry study Andrology (IF 4.5) Pub Date : 2024-03-16 Michael Zitzmann, Jann‐Frederik Cremers, Claudia Krallmann, Armin Soave, Sabine Kliesch
Background and objectiveThe longitudinal efficacy and clinical utility of Testosterone Therapy (TTh) in ameliorating functional hypogonadism (FH) remain contentious, with long‐term data being scarce. To address this lacuna, a comprehensive long‐term registry study, stratifying patients across a spectrum of hypogonadal etiologies, offers a robust investigative paradigm.Materials and methodsThis 9‐year
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Maternal use of nitrosatable drugs during pregnancy and adult male reproductive health: A population‐based cohort study Andrology (IF 4.5) Pub Date : 2024-03-16 Pernille Jul Clemmensen, Nis Brix, Jörg Schullehner, Gunnar Toft, Sandra Søgaard Tøttenborg, Karin Sørig Hougaard, Anne Ahrendt Bjerregaard, Thorhallur Ingi Halldorsson, Sjurdur Frodi Olsen, Birgitte Hansen, Leslie Thomas Stayner, Torben Sigsgaard, Henrik Kolstad, Jens Peter Ellekilde Bonde, Cecilia Høst Ramlau‐Hansen
BackgroundPrenatal exposures to xenobiotics during the masculinization programming window are suggested to impact male fecundity later in life. Frequently used nitrosatable drugs, such as penicillins and beta2‐agonists, contain amines or amides that may form teratogenic compounds in reaction with nitrite.ObjectivesWe explored whether maternal nitrosatable drug use during gestation was associated with
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Associations between a paternal healthy lifestyle score and its individual components with childhood overweight and obesity Andrology (IF 4.5) Pub Date : 2024-03-13 Adrien M. Aubert, Alexander Douglass, Celine M. Murrin, Cecily C. Kelleher, Catherine M. Phillips
Maternal healthy lifestyle behaviors during pregnancy have been associated with reduced risk of offspring overweight and obesity (OWOB). However, there has been little investigation, in the context of the Paternal Origins of Health and Disease (POHaD) paradigm, of the potential influence of the paternal lifestyle on offspring OWOB.
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Effects of edaravone on testicular torsion–detorsion injury in rats Andrology (IF 4.5) Pub Date : 2024-03-14 Yaşar Şahin, Evren Üstüner, Hidayet Tutun, Ebru Yildirim, Oğuz Eroğlu, Efe Kurtdede, Yasin Ozkabadayi, Enes Güncüm, Kürşat Kutluca, Ahmet Bilgehan Bilge
Background and objectiveThis study aimed to assess the protective ability of edaravone on testicular torsion–detorsion injury in rats.MethodsEighteen adult male Sprague–Dawley rats were randomly divided into three groups: Sham group (control, n = 6); testicular torsion/detorsion (T/D group, n = 6) and T/D+edaravone (T/D+E group, n = 6). The spermatic cords of rats of the T/D group and the T/D+E group
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Effects of chronic mild stress induced from peripuberty on sexual behavior in male rats, with or without escitalopram treatment Andrology (IF 4.5) Pub Date : 2024-03-14 Leonardo Wensing Fischer, Marina Nunes, Talita Biude Mendes, Joana Noguères Simas, Maria Martha Bernardi, Samara Urban de Oliva, Sandra Maria Miraglia
BackgroundAfter the Coronavirus Disease pandemic, depression became more present, including in adolescents. Escitalopram, a selective serotonin reuptake inhibitor, was approved in 2009 for treatment of the major depressive disorder, both in children and adolescents. The undesirable effects of antidepressants on sexual dysfunction are usually underestimated.AimsTo investigate the effects of chronic
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Pubertal testicular volume references for ruler, orchidometer, and ultrasonography measurements based on a longitudinal follow‐up Andrology (IF 4.5) Pub Date : 2024-03-14 Mikael Koskela, Helena E. Virtanen, Wiwat Rodprasert, Kirsi Jahnukainen, Jorma Toppari, Jaakko J. Koskenniemi
BackgroundTesticular volume is a marker of male pubertal development. Various clinical conditions and their treatments may influence testicular growth.ObjectivesTo create ruler‐based age‐dependent pubertal testicular volume references that enable calculation of standard deviation (SD) scores.Materials and MethodsStudy cohort comprised 65 boys who attended clinical examination twice a year from the
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Summer heat during spermatogenesis reduces in vitro blastocyst rates and affects sperm quality of next generation bulls Andrology (IF 4.5) Pub Date : 2024-03-13 Jens Vanselow, Claudia Wesenauer, Anja Eggert, Arpna Sharma, Frank Becker
BackgroundDue to global warming seasonal heat stress is an increasing problem in temperate zones. Heat stress not only decreases fertility in females, but can also be detrimental to male fertility.ObjectivesWe studied the effects of natural summer heat stress during spermatogenesis in Holstein bulls on semen quality parameters and on fertilization performance in vitro and possible intergenerational
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Transmission electron microscopy reveals the presence of SARS‐CoV‐2 in human spermatozoa associated with an ETosis‐like response Andrology (IF 4.5) Pub Date : 2024-03-12 Jorge Hallak, Elia G. Caldini, Thiago A. Teixeira, Maria Cassia Mendes Correa, Amaro N. Duarte‐Neto, Fabiola Zambrano, Anja Taubert, Carlos Hermosilla, Joël R. Drevet, Marisa Dolhnikoff, Raul Sanchez, Paulo H. N. Saldiva
BackgroundSevere acute syndrome coronavirus 2 can invade a variety of tissues, including the testis. Even though this virus is scarcely found in human semen polymerase chain reaction tests, autopsy studies confirm the viral presence in all testicular cell types, including spermatozoa and spermatids.ObjectiveTo investigate whether the severe acute syndrome coronavirus 2 is present inside the spermatozoa
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Sex differences on constitutive long non‐coding RNA expression: Modulatory effect of estradiol and testosterone in muscle cells Andrology (IF 4.5) Pub Date : 2024-03-12 Tresa López‐Royo, Laura Moreno‐Martínez, Leticia Moreno‐García, Ana Cristina Calvo, Raquel Manzano, Rosario Osta
IntroductionDespite the growing awareness of sexual dimorphism between males and females under pathological and physiological conditions, sex bias in biomedical research in animal models and patients is still present nowadays. The main objective of this work was to investigate sex differences in constitutive long non‐coding RNA expression in spinal cord and skeletal muscle from wild‐type mice.Materials
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Swimming trapper decreases the proportion of chromosomally unbalanced spermatozoa in human Robertsonian translocation carriers Andrology (IF 4.5) Pub Date : 2024-03-11 Xiao‐Nan Liu, Mei‐Yi Li, Qing‐Ling Ma, Juan Chen, Shuai Liu, Yang Yu, Ling Sun
BackgroundCarriers of reciprocal translocations often have more unbalanced spermatozoa and higher DNA fragmentation rates, elevating reproductive risk. The simple swim‐up method (SSUM) can decrease the amount of spermatozoa with abnormal chromatin structure and fragmented DNA, however, it has limited efficacy in eliminating chromosomally unbalanced sperm.MethodsThe spermatozoa of eight Robertsonian
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A preconception cohort study of sugar‐sweetened beverage consumption and semen quality Andrology (IF 4.5) Pub Date : 2024-03-07 Marlon D. Joseph, Martha R. Koenig, Andrea S. Kuriyama, Tanran R. Wang, Amelia K. Wesselink, Michael L. Eisenberg, Greg J. Sommer, Kenneth J. Rothman, Sherri O. Stuver, Lauren A. Wise, Elizabeth E. Hatch
BackgroundDietary factors, including high sugar intake, may have adverse effects on male reproduction. Studies of the association between sugar‐sweetened beverage (SSB) intake and semen quality have reported inconsistent results.ObjectiveWe estimated the effects of SSB consumption on semen quality in a North American preconception cohort study.MethodsWe analyzed baseline data from 690 males (n = 1
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Application of the sexual therapy combined with vacuum negative pressure hydropneumatic/pneumatic bubble massage in primary intravaginal anejaculation Andrology (IF 4.5) Pub Date : 2024-03-05 Qingqiang Gao, Jianhuai Chen, Bin Wang, Youfeng Hang, Songzhan Gao, Jie Yang, Yutian Dai
IntroductionPrimary intravaginal anejaculation (PIAJ) is a relatively uncommon male sexual dysfunction characterized by an inability to achieve intravaginal ejaculation during all sexual intercourse. Effective treatment options for this condition are lacking. We aimed to explore the clinical effect of the sexual therapy combined with vacuum negative pressure hydropneumatic/pneumatic bubble massage
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The association of socioeconomic status with semen parameters in a cohort of men in the United States Andrology (IF 4.5) Pub Date : 2024-03-04 Jad Badreddine, Nicholas Sellke, Stephen Rhodes, Nannan Thirumavalavan, Ramy Abou Ghayda
BackgroundSocioeconomic differences are present within the population of men who experience infertility and seek treatment.ObjectiveTo study the association of socioeconomic status with semen parameters in a group of men using mail‐in semen analyses.Materials and methodsThe records of 11,134 men that used mail‐in semen analyses from a fertility company were identified. Their demographic information
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The neurological decline and psychological factors caused by coronavirus disease 2019 may be predictors of erectile dysfunction Andrology (IF 4.5) Pub Date : 2024-03-04 Yukuai Ma, Tianle Zhu, Peng Yang, Rui Gao, Lanhui Shen, Pan Gao, Jingjing Gao, Xi Liu, Hui Jiang, Xiansheng Zhang
BackgroundSince the outbreak of coronavirus disease 2019, it has had a serious impact on people's physical and mental health. However, in our clinical work, we have found that the erectile function of coronavirus disease 2019 patients with neurological decline was often seriously affected.ObjectivesTo further explore the relationship between erectile dysfunction and neurological dysfunction caused
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Physiological role of potassium channels in mammalian germ cell differentiation, maturation, and capacitation Andrology (IF 4.5) Pub Date : 2024-03-04 Ariadna Delgado‐Bermúdez, Marc Yeste, Sergi Bonet, Elisabeth Pinart
BackgroundIon channels are essential for differentiation and maturation of germ cells, and even for fertilization in mammals. Different types of potassium channels have been identified, which are grouped into voltage‐gated channels (Kv), ligand‐gated channels (Kligand), inwardly rectifying channels (Kir), and tandem pore domain channels (K2P).Material‐MethodsThe present review includes recent findings
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Metastasis‐associated protein 1 participates in regulating luminal acidification of the epididymis via repressing estrogen receptor alpha transcription Andrology (IF 4.5) Pub Date : 2024-03-04 Pang Cheng, Jinhua Wei, Bo Liu, Ya Zhao, Binfang Ma, Xiao Feng, Mingxiang Xiong, Jie Zhao, Changhong Shi, Zhen Li
BackgroundAs a component of the nucleosome remodeling and deacetylating (NuRD) complex, metastasis‐associated protein 1 (MTA1) has been reported to be abundant in male reproductive system and might participate in spermatogenesis and sperm maturation, whereas the precise functional role of MTA1 in these processes is still undetermined.ObjectiveTo investigate the effect and potential function of MTA1
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Real‐life users of hormonal or thermal male contraception: An analysis of female partners’ motivation, experience, and satisfaction Andrology (IF 4.5) Pub Date : 2024-02-29 Clothilde Laurent, Roger Mieusset, Jean‐Claude Soufir, Jeanne Perrin
BackgroundTwo male contraceptive methods that inhibit spermatogenesis currently exist: thermal male contraception and hormonal male contraception. Only five studies have been conducted on the acceptability of these methods among men; among women, only the hypothetical acceptability of such a male contraceptive approach as the sole contraception method used by a couple has been evaluated.ObjectivesTo
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Evaluating the impact of pre‐diagnostic use of statins and testosterone replacement therapy on mortality outcomes in older men with hormone‐related cancers: Surveillance, Epidemiology, and End Results‐Medicare 2007–2015 Andrology (IF 4.5) Pub Date : 2024-02-29 Maryam R. Hussain, Omer Abdelgadir, Efstathia Polychronopoulou, Konstantinos K. Tsilidis, Laith Alzweri, Alejandro Villasante‐Tezanos, Jacques Baillargeon, Steven Canfield, Yong‐Fang Kuo, David S. Lopez
BackgroundThe link between the pre‐diagnostic use of statins and testosterone replacement therapy and their impact on hormone‐related cancers, prostate cancer, colorectal cancer, and male breast cancer survival remains a topic of controversy. Further, there is a knowledge gap concerning the joint effects of statins and testosterone replacement therapy on hormone‐related cancer survival outcomes.ObjectiveTo
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A detection model of testis‐derived circular RNAs in serum for predicting testicular sperm retrieval rate in non‐obstructive azoospermia patients Andrology (IF 4.5) Pub Date : 2024-02-29 Mo‐qi Lv, Yan‐qi Yang, Yi‐Xin Li, Liang Zhou, Pan Ge, Rui‐fang Sun, Jian Zhang, Jun‐cheng Gao, Liu‐qing Qu, Qi‐ya Jing, Pin‐cheng Li, Yu‐jia Yan, Hai‐xu Wang, He‐cheng Li, Dang‐xia Zhou
BackgroundMicrodissection testicular sperm extraction is an effective method to retrieve sperm from non‐obstructive azoospermia patients. However, its successful rate is less than 50%.ObjectivesTo identify the predictive value of circular RNAs in serum for sperm retrieval rate in non‐obstructive azoospermia patients.Materials and methods180 non‐obstructive azoospermia patients were recruited in this
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Transgenerational effects of paternal exposures: the role of germline de novo mutations Andrology (IF 4.5) Pub Date : 2024-02-23 Hojat Dehghanbanadaki, Masaya Jimbo, Kiarad Fendereski, Jason Kunisaki, Joshua J Horns, Joemy M. Ramsay, Kelli X. Gross, Alexander W. Pastuszak, James M. Hotaling
Germline de novo mutations (DNMs) refer to spontaneous mutations arising during gametogenesis, resulting in genetic changes within germ cells that are subsequently transmitted to the next generation. While the impact of maternal exposures on germline DNMs has been extensively studied, more recent studies have begun to highlight the increasing importance of the effects of paternal factors. In this review
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Serum total testosterone is associated with phosphate and calcium excretion in response to oral phosphate loading in healthy middle-aged males Andrology (IF 4.5) Pub Date : 2024-02-20 Jaya K. Sharma, Mandy E. Turner, Amanda S. Paynter, Patrick A. Norman, Christine A. White, Emilie C. Ward, Michael A. Adams, Rachel M. Holden
Androgen receptors are expressed in the kidney and serum testosterone is negatively associated with serum phosphate in males, suggesting a role of testosterone in renal phosphate handling. In this cross-sectional study, we examined the association of serum total and free testosterone with acute phosphate and calcium excretion in males in response to an oral phosphate challenge. Thirty-five healthy
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Whole‐exome sequencing identifies ADGB as a novel causative gene for male infertility in humans: from motility to fertilization Andrology (IF 4.5) Pub Date : 2024-02-22 Yang Gao, Liting Liu, Shixiong Tian, Chunyu Liu, Mingrong Lv, Huan Wu, Dongdong Tang, Bing Song, Qunshan Shen, Yuping Xu, Ping Zhou, Zhaolian Wei, Feng Zhang, Yunxia Cao, Xiaojin He
ObjectivesIn male mice, adgb‐knockout has been reported to cause male infertility with spermatogenesis defects involving flagella and acrosome. However, this remains unclear for humans.Materials and methodsSequencing studies were conducted in a research hospital on samples from three unrelated infertile men with severe asthenoteratozoospermia from Han Chinese families. Data were collected through rigorous
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EHMT2/G9a and EZH2: Epimarkers in testicular germ cell tumors Andrology (IF 4.5) Pub Date : 2024-02-21 Helena Estevão‐Pereira, Catarina Guimarães‐Teixeira, Bianca C. T. Flores, Filipa Moreira‐Silva, Nuno Tiago Tavares, Rita Guimarães, Isaac Braga, Joaquina Maurício, Rui Henrique, Carmen Jerónimo, João Lobo
BackgroundTesticular germ cell tumors remain the most frequent solid malignancies in young males. Despite excellent prognosis, the fact that only 60% of patients at diagnosis have elevated serum tumor markers (dependent on stage and histology) and the poor quality of life of patients who develop resistance to chemotherapy cannot be neglected. Consequently, it is mandatory to bring out novel biomarkers
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Testicular biopsies in men with testicular microlithiasis and additional risk factors for cancer: A case series Andrology (IF 4.5) Pub Date : 2024-02-20 Rasmus Hassing Frandsen, Emil Durukan, Elena von Rohden, Christian Fuglesang S. Jensen, Andreas Key Milan Thamsborg, Nessn Azawi, Mikkel Fode
BackgroundTesticular microlithiasis is the presence of small calcifications in the testicular parenchyma. The association between testicular microlithiasis and germ cell neoplasia in situ, a precursor to testicular cancer, is still unclear.ObjectivesTo determine the incidence of germ cell neoplasia in situ in men with testicular microlithiasis and evaluate the indication for testicular biopsy according
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Is varicocoelectomy indicated in infertile men with isolated teratozoospermia? a systematic review and meta-analysis Andrology (IF 4.5) Pub Date : 2024-02-12 Murat Dursun, Hüseyin Beşiroğlu, Reşat Aydın, Turgay Kaçan, Ahmet Halil Sevinç, Ateş Kadıoğlu
Clinical palpable varicocoeles in conjunction with isolated teratozoospermia are rarely observed. Therefore, the effects of varicocoelectomy on sperm morphology are not clear. The aim of this meta-analysis is to compile studies that assess the effectiveness of varicocoelectomy in isolated teratozoospermia to reach a more consistent and reliable conclusion.
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The paternal role in pregnancy loss Andrology (IF 4.5) Pub Date : 2024-02-09 Wade Muncey, Michael Scott, Ruth B. Lathi, Michael L. Eisenberg
In this comprehensive review, the intricate relationship between paternal factors and pregnancy loss is examined. While pregnancy loss has historically been predominantly attributed to maternal factors, recent research underscores the significant contribution of the male partner. The review delves into various aspects of paternal influence, including paternal age, health, chromosome abnormalities,
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The association between ambient temperature and semen quality in a Northern Peninsular Province, China Andrology (IF 4.5) Pub Date : 2024-01-30 Li Wang, Yinan Qu, Wenkai Han, Meng Cai, Wei Ma, Qi Zhao, Zi-Jiang Chen
Extreme ambient temperature has been linked to decline in males’ semen quality. Although the temperature–semen quality association has been examined in certain cities of South China, how the effect size of the extreme temperature may lag over critical windows in spermatogenesis and whether the strength of association may vary in North China have yet been adequately explored.
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3-Hydroxy-3-methylglutaryl-CoA synthase 2 facilitates erectile dysfunction via inhibiting autophagy by enhancing the mammalian target of rapamycin pathway in type 1 diabetic mellitus rats Andrology (IF 4.5) Pub Date : 2024-01-25 Zhiqiang Dai, Yang Zeng, Xiao Tan, Tao Zhou, Xiong Li, Qingfu Deng
The relationship between erectile dysfunction (ED) and type 1 diabetes mellitus (T1DM) is currently a hot topic of medical research. It has been reported that autophagy plays a crucial role in causing erectile dysfunction in T1DM. Recent research has shown that mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2) is strongly linked to the development of T1DM. However, the specific mechanism
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Novel variations in TENT5D lead to teratozoospermia in infertile patients Andrology (IF 4.5) Pub Date : 2024-01-16 Ying-Teng Zhang, Gan Shen, Liang-Chai Zhuo, Xue Yang, Su-Yan Wang, Tie-Chao Ruan, Chuan Jiang, Xiang Wang, Yan Wang, Yi-Hong Yang, Ying Shen
Teratozoospermia is the main pathogenic factor of male infertility. However, the genetic etiology of teratozoospermia is largely unknown. This study aims to clarify the relationship between novel variations in TENT5D and teratozoospermia in infertile patients.
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A global perspective: characteristics of infertility-related randomized clinical trials Andrology (IF 4.5) Pub Date : 2024-01-17 Yu Xi, Ya-Lei Cao, Li-Yuan Tao, Song-Zhan Gao, Zi-Run Jin, Jian-Xing Cheng, Hui Jiang, Zhe Zhang
Infertility is a prevalent global condition, and emerging reproductive technologies may enhance its evaluation and treatment. Understanding the current features of randomized clinical trials in infertility is crucial for improving study design and ensuring the translation of results for patient benefits.
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Heme-induced corpus cavernosum relaxation and its implications for priapism in sickle cell disease: a mechanistic insight Andrology (IF 4.5) Pub Date : 2024-01-17 Dalila Andrade Pereira, Danillo Andrade Pereira, Tammyris Helena Rebecchi Silveira, Fabiano Beraldi Calmasini, Arthur L. Burnett, Fernando Ferreira Costa, Fábio Henrique Silva
Patients with sickle cell disease (SCD) experience intravascular hemolysis, leading to elevated plasma heme levels. This phenomenon has been associated with increased priapism in men with SCD. The heme group can be metabolized by heme oxygenase (HO), generating carbon monoxide (CO), which is known to promote smooth muscle relaxation via soluble guanylyl cyclase (sGC)–cyclic guanosine monophosphate
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Repetitive transcranial magnetic stimulation via the hippocampal brain-derived neurotrophic factor–tyrosine kinase receptor B pathway to affect sexual behavior and neuroplasticity in rapid ejaculation rats Andrology (IF 4.5) Pub Date : 2024-01-17 Qiushi Liu, Ming Wang, Weinan Wang, Shaoyu Yue, Tommaso B. Jannini, Emmanuele A. Jannini, Hui Jiang, Xiansheng Zhang
Premature ejaculation (PE) is the most prevalent sexual dysfunction among men. Eejaculation involves a complex nervous mechanism in which the ejaculatory centers play a key role in modulating sperm emission. Although treatment possibilities span from psychotherapy to pharmacological approaches, results show inconsistent efficacy. In this context, the emergence of repetitive transcranial magnetic stimulation
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Trends in the use of testicular prostheses in Germany: a total population analysis from 2006–2021 Andrology (IF 4.5) Pub Date : 2024-01-16 Cem Aksoy, Philipp Reimold, Philipp Karschuck, Christer Groeben, Rainer Koch, Nicole Eisenmenger, Smita Thoduka, Aristeidis Zacharis, Hans Schmelz, Johannes Huber, Luka Flegar
Testicular tumors are the most common malignancies in young adults and their incidence is growing. The implantation of a testicular prosthesis, for example, during orchiectomy is a standard procedure but its frequency in Germany is unknown. This study aims to analyze trends of testicular prosthesis implantation in recent years in Germany.
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New insights into sperm physiology regulation: Enlightenment from G-protein-coupled receptors Andrology (IF 4.5) Pub Date : 2024-01-15 Pengyuan Dai, Chen Chen, Jingyan Yu, Chaoye Ma, Xiaoning Zhang
G-protein-coupled receptors are critical in many physiological and pathological processes in various organs. Serving as the control panel for sensing extracellular stimuli, G-protein-coupled receptors recognise various ligands, including light, temperature, odours, pheromones, hormones, neurotransmitters, chemokines, etc. Most recently, G-protein-coupled receptors residing in spermatozoa have been
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Cost-effectiveness of testosterone treatment utilising individual patient data from randomised controlled trials in men with low testosterone levels Andrology (IF 4.5) Pub Date : 2024-01-17 Rodolfo Hernández, Nipun Lakshitha de Silva, Jemma Hudson, Moira Cruickshank, Richard Quinton, Paul Manson, Waljit S. Dhillo, Siladitya Bhattacharya, Miriam Brazzelli, Channa N. Jayasena
Testosterone is safe and highly effective in men with organic hypogonadism, but worldwide testosterone prescribing has recently shifted towards middle-aged and older men, mostly with low testosterone related to age, diabetes and obesity, for whom there is less established evidence of clinical safety and benefit. The value of testosterone treatment in middle-aged and older men with low testosterone
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Impact of sexual function domains on sexual satisfaction and quality of life: Importance across the age spectrum Andrology (IF 4.5) Pub Date : 2024-01-16 Jackson J. Cabo, Melissa R. Kaufman, Niels V. Johnsen
Sexual satisfaction is an important component of global quality life for many adult men. Substantial gaps exist in our appreciation of how age mediates sexual satisfaction in the context of functional sexual measures. We sought to evaluate modifiable factors associated with overall sexual satisfaction and health-related quality of life (HRQoL) in a large, age-stratified community-based sample of adult
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Comparative analysis of surgical modalities for the gynecomastia treatment: efficiency and aesthetic outcomes Andrology (IF 4.5) Pub Date : 2024-01-16 Debo Chen, Jialin Chen, Yiqin Huang, Chengye Hong, Liangqiang Li, Bimei Cai, Zhipeng Hong
This retrospective study rigorously compares the clinical efficacy of three surgical methodologies for treating gynecomastia while providing guidance for future surgical modality selection. We analyzed records of 77 gynecomastia patients treated between January 2015 and October 2022. Patients were categorized into three groups: Group A (subcutaneous gland resection via areola incision), Group B (liposuction
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MiRNA-100 ameliorates diabetes mellitus-induced erectile dysfunction by modulating autophagy, anti-inflammatory, and antifibrotic effects Andrology (IF 4.5) Pub Date : 2024-01-16 Beining Li, Peng Hu, Kang Liu, Wenchao Xu, Jiaxin Wang, Qinyu Li, Bingliang Chen, Yuxuan Deng, Chenglin Han, Taotao Sun, Xinqi Liu, Mingchao Li, Tao Wang, Jihong Liu, Huang Lin, Ke Rao
Diabetes mellitus-induced erectile dysfunction (DMED) has become a common disease in adult men that can seriously reduce the quality of life of patients, and new therapies are urgently needed. miRNA-100 has many targets and can induce autophagy and reduce fibrosis by inhibiting the mTOR pathway and the TGF-β pathway. However, no research has been conducted with miR-100 in the field of DMED, and the
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Sperm selection by zona adhesion improves assisted reproductive treatment outcomes Andrology (IF 4.5) Pub Date : 2024-01-15 Rumiana Ganeva, Dimitar Parvanov, Nina Vidolova, Maria Handzhiyska, Margarita Ruseva, Magdaleva Vasileva, Kristina Nikolova, Ivka Ivanova, Miray Shaban, Joanna Shabarkova, Rayna Hristova, Milena Miladinova, Georgi Stamenov
Zona pellucida is one of the main selective barriers for the spermatozoa before reaching the oocyte. Using native zona in the sperm selection prior to Intracytoplasmic Sperm Injection (ICSI) has been proven effective but inconvenient approach in In Vitro Fertilisation (IVF) laboratory. The application of autologous solubilised zonae pellucidae in the sperm selection prior to ICSI has not been studied
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An integrated approach for improving clinical management of non-obstructive azoospermia Andrology (IF 4.5) Pub Date : 2024-01-14 Fu Shi, Ye Liu, Zheng Chen, Dongliang Li, Yuanqing Yao, Meixun Zhou, Yumin Zhuo, Xin Ma, Dandan Cao
Non-obstructive azoospermia is the most severe form of male infertility. A testicular biopsy is required for the diagnosis of non-obstructive azoospermia, and the causal factors for non-obstructive azoospermia remain unknown.
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Knockdown of programmed cell death factor 4 restores erectile function by attenuating apoptosis in rats with bilateral cavernous nerve crush injury Andrology (IF 4.5) Pub Date : 2024-01-13 Yunlong Ge, Tian Xia, Zejia Feng, Yuhang Xi, Daoyuan Hu, Yude Hong, Bowen Tang, Jianjie Wu, Jialiang Chen, Hengjun Xiao
Apoptosis is an important pathologic mechanism of erectile dysfunction after radical prostatectomy. Studies have shown that programmed cell death factor 4 is connected to the modulation of apoptosis in many cells. However, the programmed cell death factor 4 function in the cavernous nerve injury erectile dysfunction is unclear.