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Lessons From Insulin: Policy Prescriptions for Affordable Diabetes and Obesity Medications Diabetes Care (IF 16.2) Pub Date : 2024-03-27 Kathryn E. Nagel, Reshma Ramachandran, Kasia J. Lipska
Escalating insulin prices have prompted public scrutiny of the practices of drug manufacturers, pharmacy benefit managers, health insurers, and pharmacies involved in production and distribution of medications. As a result, a series of policies have been proposed or enacted to improve insulin affordability and foster greater equity in access. These policies have implications for other diabetes and
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Acute Effects of Vibrating Insoles on Dynamic Balance and Gait Quality in Individuals With Diabetic Peripheral Neuropathy: A Randomized Crossover Study Diabetes Care (IF 16.2) Pub Date : 2024-03-27 Giorgio Orlando, Steven Brown, Edward Jude, Frank L. Bowling, Andrew J.M. Boulton, Neil D. Reeves
OBJECTIVE This study investigated the effects of vibrating insoles on dynamic balance and gait quality during level and stair walking and explored the influence of vibration type and frequency in individuals with diabetic peripheral neuropathy (DPN). RESEARCH DESIGN AND METHODS Twenty-two men with DPN were assessed for gait quality and postural and dynamic balance during walking and stair negotiation
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Effects of Tirzepatide Versus Basal Insulins in People With Type 2 Diabetes and Different Baseline Glycemic Patterns: Post Hoc Analyses of the SURPASS-3 and SURPASS-4 Trials Diabetes Care (IF 16.2) Pub Date : 2024-03-26 Francesco Giorgino, Denise R. Franco, Claudia Nicolay, Andrea Hemmingway, Ángel Rodríguez, Russell J. Wiese
OBJECTIVE This post hoc analysis assessed change from baseline to week 52 in glycemic parameters for tirzepatide (5, 10, 15 mg) versus insulin degludec (SURPASS-3 trial) and glargine (SURPASS-4 trial) in people with type 2 diabetes and different baseline glycemic patterns, based on fasting serum glucose (FSG) and postprandial glucose (PPG) values. RESEARCH DESIGN AND METHODS Participant subgroups with
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Diabetes Management in Detention Facilities: A Statement of the American Diabetes Association Diabetes Care (IF 16.2) Pub Date : 2024-03-25 Daniel L. Lorber, Nuha A. ElSayed, Raveendhara R. Bannuru, Viral Shah, Michael Puisis, Jill Crandall, Sarah Fech-Baughman, Barbara Wakeen, Jo Jo Dantone, Robin Hunter-Buskey, Kenneth Moritsugu, Emily Wang, Marisa Desimone, Ruth Weinstock, Aaron Fischer, Jennifer Sherman, Gabe Eber, William Shefelman
This statement provides guidance for diabetes care in detention facilities. It focuses on areas where the processes for delivery of care to people with diabetes in detention facilities may differ from those in the community, and key points are made at the end of each section. Areas of emphasis, which inform multiple aspects discussed in this statement, include 1) timely identification or diagnosis
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Erratum. Our National Approach to Diabetes. Diabetes Care 2023;46:252–254 Diabetes Care (IF 16.2) Pub Date : 2024-03-22 Robert M. Califf
In the Duality of Interest section of the article cited above, it was incorrectly noted, due to a clerical error prior to manuscript submission, that the author served on the board of directors for the Center for Policy Analysis on Trade and Health (CPATH); the correct institution is the Critical Path Institute (C-Path). The author apologizes for the error. The online version of the article (https://doi
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Longitudinal Change in Serum Neurofilament Light Chain in Type 2 Diabetes and Early Diabetic Polyneuropathy: ADDITION-Denmark Diabetes Care (IF 16.2) Pub Date : 2024-03-19 Laura L. Määttä, Signe T. Andersen, Tina Parkner, Claus V.B. Hviid, Lasse Bjerg, Mustafa A. Kural, Morten Charles, Esben Søndergaard, Jens Kuhle, Hatice Tankisi, Daniel R. Witte, Troels S. Jensen
OBJECTIVE To investigate the longitudinal development of neurofilament light chain (NfL) levels in type 2 diabetes with and without diabetic polyneuropathy (+/−DPN) and to explore the predictive potential of NfL as a biomarker for DPN. RESEARCH DESIGN AND METHODS We performed retrospective longitudinal case-control analysis of data from 178 participants of the Anglo-Danish-Dutch Study of Intensive
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HLA Class II (DR, DQ, DP) Genes Were Separately Associated With the Progression From Seroconversion to Onset of Type 1 Diabetes Among Participants in Two Diabetes Prevention Trials (DPT-1 and TN07) Diabetes Care (IF 16.2) Pub Date : 2024-03-18 Lue Ping Zhao, George K. Papadopoulos, Jay S. Skyler, Alberto Pugliese, Hemang M. Parikh, William W. Kwok, Terry P. Lybrand, George P. Bondinas, Antonis K. Moustakas, Ruihan Wang, Chul-Woo Pyo, Wyatt C. Nelson, Daniel E. Geraghty, Åke Lernmark
OBJECTIVE To explore associations of HLA class II genes (HLAII) with the progression of islet autoimmunity from asymptomatic to symptomatic type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS Next-generation targeted sequencing was used to genotype eight HLAII genes (DQA1, DQB1, DRB1, DRB3, DRB4, DRB5, DPA1, DPB1) in 1,216 participants from the Diabetes Prevention Trial-1 and Randomized Diabetes Prevention
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Metabolic Syndrome Traits Increase the Risk of Major Adverse Liver Outcomes in Type 2 Diabetes Diabetes Care (IF 16.2) Pub Date : 2024-03-18 Ying Shang, Emilie Toresson Grip, Angelo Modica, Helena Skröder, Oskar Ström, Fady Ntanios, Soffia Gudbjörnsdottir, Hannes Hagström
OBJECTIVE Type 2 diabetes (T2D) increases the risk for major adverse liver outcomes (MALOs), including cirrhosis and its complications. Patients with T2D frequently have other traits of the metabolic syndrome (MetS). It remains uncertain whether there is a synergistic effect of accumulating MetS traits on future MALO risk. RESEARCH DESIGN AND METHODS Patients with T2D without a history of liver disease
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Comparing Continuous Glucose Monitoring and Blood Glucose Monitoring in Adults With Inadequately Controlled, Insulin-Treated Type 2 Diabetes (Steno2tech Study): A 12-Month, Single-Center, Randomized Controlled Trial Diabetes Care (IF 16.2) Pub Date : 2024-03-15 Nanna Lind, Merete B. Christensen, Dorte L. Hansen, Kirsten Nørgaard
OBJECTIVE To compare the 12-month effects of continuous glucose monitoring (CGM) versus blood glucose monitoring (BGM) in adults with insulin-treated type 2 diabetes. RESEARCH DESIGN AND METHODS This is a single-center, parallel, open-label, randomized controlled trial including adults with inadequately controlled, insulin-treated type 2 diabetes from the outpatient clinic at Steno Diabetes Center
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Haptoglobin Phenotype and Intensive Glycemic Control for Coronary Artery Disease Risk Reduction in People With Type 2 Diabetes: The ADVANCE Study Diabetes Care (IF 16.2) Pub Date : 2024-03-14 Leah E. Cahill, Rachel A. Warren, Allie S. Carew, Andrew P. Levy, John Sapp, Michelle Samuel, Elizabeth Selvin, Samantha K. Lavallée, Neil Poulter, Michel Marre, Stephen Harrap, Giuseppe Mancia, Katie Harris, John Chalmers, Mark Woodward, Eric B. Rimm
OBJECTIVE Intensive glycemic control reduced coronary artery disease (CAD) events among the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study participants with the haptoglobin (Hp)2-2 phenotype but not in participants without the Hp2-2 phenotype. It is unknown whether and how these results translate across different demographic/clinical characteristics and treatment strategies. RESEARCH
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The Difference Between Cystatin C- and Creatinine-Based Estimated Glomerular Filtration Rate and Risk of Diabetic Microvascular Complications Among Adults With Diabetes: A Population-Based Cohort Study Diabetes Care (IF 16.2) Pub Date : 2024-03-12 Daijun He, Bixia Gao, Jinwei Wang, Chao Yang, Ming-Hui Zhao, Luxia Zhang
OBJECTIVE The impact of the difference between cystatin C- and creatinine-based estimated glomerular filtration rate (eGFRdiff) on diabetic microvascular complications (DMCs) remains unknown. We investigated the associations of eGFRdiff with overall DMCs and subtypes, including diabetic retinopathy (DR), diabetic kidney disease (DKD), and diabetic neuropathy (DN). RESEARCH DESIGN AND METHODS This prospective
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Impact of Type 2 Diabetes and Glycated Hemoglobin Levels Within the Recommended Target Range on Mortality in Older Adults With Cognitive Impairment Receiving Care at a Memory Clinic: NCGG-STORIES Diabetes Care (IF 16.2) Pub Date : 2024-03-12 Taiki Sugimoto, Takashi Sakurai, Kazuaki Uchida, Yujiro Kuroda, Haruhiko Tokuda, Takuya Omura, Taiji Noguchi, Ayane Komatsu, Takeshi Nakagawa, Kosuke Fujita, Nanae Matsumoto, Rei Ono, Paul K. Crane, Tami Saito
OBJECTIVE To determine the impact of type 2 diabetes and glycated hemoglobin (HbA1c) levels within the recommended target range according to the Japan Diabetes Society/Japan Geriatrics Society Joint Committee on mortality in older adults with cognitive impairment. RESEARCH DESIGN AND METHODS This retrospective cohort study included 1,528 and 468 patients aged ≥65 years without and with type 2 diabetes
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Disparities Between Teleretinal Imaging Findings and Patient-Reported Diabetic Retinopathy Status and Follow-Up Eye Care Interval: A 10-Year Prospective Study Diabetes Care (IF 16.2) Pub Date : 2024-03-08 Paolo S. Silva, Jerry D. Cavallerano, Jennifer K. Sun, Ann M. Tolson, Dorothy Tolls, Martin J. Abrahamson, Lloyd M. Aiello, Lloyd Paul Aiello
OBJECTIVE To assess self-reported awareness of diabetic retinopathy (DR) and concordance of eye examination follow-up compared with findings from concurrent retinal images. RESEARCH DESIGN AND METHODS We conducted a prospective observational 10-year study of 26,876 consecutive patients with diabetes who underwent retinal imaging during an endocrinology visit. Awareness and concordance were evaluated
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Natural History of Type 2 Diabetes in Indians: Time to Progression Diabetes Care (IF 16.2) Pub Date : 2024-03-01 K. M. Venkat Narayan, Dimple Kondal, Howard H. Chang, Deepa Mohan, Unjali P. Gujral, Ranjit Mohan Anjana, Lisa R. Staimez, Shivani A. Patel, Mohammed K. Ali, Dorairaj Prabhakaran, Nikhil Tandon, Viswanathan Mohan
OBJECTIVE To describe the natural history of diabetes in Indians. RESEARCH DESIGN AND METHODS Data are from participants older than 20 years in the Centre for Cardiometabolic Risk Reduction in South Asia longitudinal study. Glycemic states were defined per American Diabetes Association criteria. Markov models were used to estimate annual transition probabilities and sojourn time through states. RESULTS
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Exploring Factors That Influence Postexercise Glycemia in Youth With Type 1 Diabetes in the Real World: The Type 1 Diabetes Exercise Initiative Pediatric Study (T1DEXIP) Diabetes Care (IF 16.2) Pub Date : 2024-02-27 Jennifer L. Sherr, Simon Bergford, Robin L. Gal, Mark A. Clements, Susana R. Patton, Peter Calhoun, Lindsey C. Beaulieu, Michael C. Riddell
OBJECTIVE To explore 24-h postexercise glycemia and hypoglycemia risk, data from the Type 1 Diabetes Exercise Initiative Pediatric (T1DEXIP) study were analyzed to examine factors that may influence glycemia. RESEARCH DESIGN AND METHODS This was a real-world observational study with participant self-reported physical activity, food intake, and insulin dosing (multiple daily injection users). Heart
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Cardiovascular and Kidney Risks in Individuals With Type 2 Diabetes: Contemporary Understanding With Greater Emphasis on Excess Adiposity Diabetes Care (IF 16.2) Pub Date : 2024-02-27 Naveed Sattar, Calum Presslie, Martin K. Rutter, Darren K. McGuire
In high-income countries, rates of atherosclerotic complications in type 2 diabetes have declined markedly over time due to better management of traditional risk factors including lipids, blood pressure and glycemia levels. Population-wide reductions in smoking have also helped lower atherosclerotic complications and so reduce premature mortality in type 2 diabetes. However, as excess adiposity is
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Accuracy and Feasibility of Real-time Continuous Glucose Monitoring in Critically Ill Patients After Abdominal Surgery and Solid Organ Transplantation Diabetes Care (IF 16.2) Pub Date : 2024-02-27 Barbora Voglová Hagerf, Marek Protus, Lenka Nemetova, Milos Mraz, Eva Kieslichova, Eva Uchytilova, Veronika Indrova, Jan Lelito, Peter Girman, Martin Haluzík, Janka Franekova, Veronika Svirlochova, David C. Klonoff, Michael A. Kohn, Antonin Jabor
OBJECTIVE Glycemia management in critical care is posing a challenge in frequent measuring and adequate insulin dose adjustment. In recent years, continuous glucose measurement has gained accuracy and reliability in outpatient and inpatient settings. The aim of this study was to assess the feasibility and accuracy of real-time continuous glucose monitoring (CGM) in ICU patients after major abdominal
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A Diabetes Pregnancy Technology Roadmap: The 2023 Norbert Freinkel Award Lecture Diabetes Care (IF 16.2) Pub Date : 2024-02-23 Helen R. Murphy
Norbert Freinkel emphasized the need for “more aggressive therapy with exogenous insulin” during type 1 diabetes (T1D) pregnancy. Recent advances in diabetes technology, continuous glucose monitoring (CGM), and hybrid closed-loop (HCL) insulin delivery systems allow us to revisit Freinkel’s observations from a contemporary perspective. The Continuous Glucose Monitoring in Women With Type 1 Diabetes
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Estimating Glycemia From HbA1c and CGM: Analysis of Accuracy and Sources of Discrepancy Diabetes Care (IF 16.2) Pub Date : 2024-02-23 Veronica Tozzo, Matthew Genco, Shammah O. Omololu, Christopher Mow, Hasmukh R. Patel, Chhaya H. Patel, Samantha N. Ho, Evie Lam, Batoul Abdulsater, Nikita Patel, Robert M. Cohen, David M. Nathan, Camille E. Powe, Deborah J. Wexler, John M. Higgins
OBJECTIVE To examine the accuracy of different periods of continuous glucose monitoring (CGM), hemoglobin A1c (HbA1c), and their combination for estimating mean glycemia over 90 days (AG90). RESEARCH DESIGN AND METHODS We retrospectively studied 985 CGM periods of 90 days with <10% missing data from 315 adults (86% of whom had type 1 diabetes) with paired HbA1c measurements. The impact of mean red
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Waking Up to the Importance of Sleep in Type 2 Diabetes Management: A Narrative Review Diabetes Care (IF 16.2) Pub Date : 2024-02-23 Joseph Henson, Alix Covenant, Andrew P. Hall, Louisa Herring, Alex V. Rowlands, Thomas Yates, Melanie J. Davies
For the first time, the latest American Diabetes Association/European Association for the Study of Diabetes (ADA/EASD) consensus guidelines have incorporated a growing body of evidence linking health outcomes associated with type 2 diabetes to the movement behavior composition over the whole 24-h day. Of particular note, the importance of sleep as a key lifestyle component in the management of type
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Disparities in Acute and Chronic Complications of Diabetes Along the U.S. Rural-Urban Continuum Diabetes Care (IF 16.2) Pub Date : 2024-02-22 Kyle Steiger, Jeph Herrin, Kavya Sindhu Swarna, Esa M. Davis, Rozalina G. McCoy
OBJECTIVE To determine the relative hazards of acute and chronic diabetes complications among people with diabetes across the U.S. rural-urban continuum. RESEARCH DESIGN AND METHODS This retrospective cohort study used the OptumLabs Data Warehouse, a deidentified data set of U.S. commercial and Medicare Advantage beneficiaries, to follow 2,901,563 adults (age ≥18 years) with diabetes between 1 January
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Historic Redlining and Impact of Structural Racism on Diabetes Prevalence in a Nationally Representative Sample of U.S. Adults Diabetes Care (IF 16.2) Pub Date : 2024-02-22 Leonard E. Egede, Rebekah J. Walker, Jennifer A. Campbell, Sebastian Linde
OBJECTIVE We investigated direct and indirect relationships between historic redlining and prevalence of diabetes in a U.S. national sample. RESEARCH DESIGN AND METHODS Using a previously validated conceptual model, we hypothesized pathways between structural racism and prevalence of diabetes via discrimination, incarceration, poverty, substance use, housing, education, unemployment, and food access
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Socioeconomic Deprivation and the Risk of Sight-Threatening Diabetic Retinopathy (STDR): A Population-Based Cohort Study in the U.K. Diabetes Care (IF 16.2) Pub Date : 2024-02-22 Luyuan Tan, Jingya Wang, Jieun Han, Christopher Sainsbury, Alastair K. Denniston, Francesca L. Crowe, Konstantinos A. Toulis, Muhammad Ali Karamat, Mi Yao, Krishnarajah Nirantharakumar
OBJECTIVE To evaluate the associations between socioeconomic deprivation and sight-threatening diabetic retinopathy (STDR) in individuals with type 1 (T1D) and type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS Data from 175,628 individuals with diabetes in the Health Improvement Network were used to assess the risk of STDR across Townsend Deprivation Index quantiles using Cox proportional hazard regression
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Continuous Glucose Monitoring–Based Metrics and Hypoglycemia Duration in Insulin-Experienced Individuals With Long-Standing Type 2 Diabetes Switched From a Daily Basal Insulin to Once-Weekly Insulin Icodec: Post Hoc Analysis of ONWARDS 2 and ONWARDS 4 Diabetes Care (IF 16.2) Pub Date : 2024-02-21 Harpreet S. Bajaj, Björg Ásbjörnsdóttir, Lisbeth Carstensen, Christian Laugesen, Chantal Mathieu, Athena Philis-Tsimikas, Tadej Battelino
OBJECTIVE This post hoc analysis assessed continuous glucose monitoring (CGM)–based metrics and hypoglycemia duration with once-weekly insulin icodec versus once-daily basal insulin analogs in insulin-experienced individuals with long-standing type 2 diabetes from two 26-week phase 3a trials (ONWARDS 2 and ONWARDS 4). RESEARCH DESIGN AND METHODS Time in range (TIR) (3.9–10.0 mmol/L), time above range
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Erratum. Computed Tomography Versus Invasive Coronary Angiography in Patients With Diabetes and Suspected Coronary Artery Disease. Diabetes Care 2023;46:2015–2023 Diabetes Care (IF 16.2) Pub Date : 2024-02-21 Theodora Benedek, Viktoria Wieske, Bálint Szilveszter, Klaus F. Kofoed, Patrick Donnelly, José Rodriguez-Palomares, Andrejs Erglis, Josef Veselka, Gintarė Šakalytė, Nada Čemerlić Ađić, Matthias Gutberlet, Ignacio Diez, Gershan Davis, Elke Zimmermann, Cezary Kępka, Radosav Vidakovic, Marco Francone, Małgorzata Ilnicka-Suckiel, Fabian Plank, Juhani Knuuti, Rita Faria, Stephen Schröder, Colin Berry, Luca
In the abstract of the article cited above, the clinical trial number for DISCHARGE (NCT02400229) was inadvertently omitted. The abstract has been revised to include the ClinicalTrials.gov identification. The editors apologize for the error. The online version of the article (https://doi.org/10.2337/dc23-0710) has been updated to correct the error.
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Improved Satisfaction While Maintaining Safety and High Time in Range (TIR) With a Medtronic Investigational Enhanced Advanced Hybrid Closed-Loop System (e-AHCL) Diabetes Care (IF 16.2) Pub Date : 2024-02-21 Cheng Yi Yuan, Yee W. Kong, Tess Amoore, Katrin Brown, Benyamin Grosman, Alicia Jenkins, Hannah Jones, Natalie Kurtz, Melissa H. Lee, Richard MacIsaac, Emma Netzer, Barbora Paldus, Lesley Robinson, Anirban Roy, Catriona M. Sims, Steven Trawley, Sara Vogrin, David N. O’Neal
OBJECTIVE To determine feasibility and compare acceptance of an investigational Medtronic enhanced Advanced Hybrid Closed Loop (e-AHCL) system in adults with type 1 diabetes with earlier iterations. RESEARCH DESIGN AND METHODS Nonrandomized three-stage (12 weeks each) exploratory study comparing e-AHCL (Bluetooth-enabled MiniMed 780G insulin pump with automatic data upload [780G] incorporating an updated
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Identifying Preferred Features of Weight Loss Programs for Adults With or at Risk of Type 2 Diabetes: A Discrete Choice Experiment With 3,960 Adults in the U.K. Diabetes Care (IF 16.2) Pub Date : 2024-02-20 John Buckell, Caroline A. Mitchell, Kate Fryer, Carolyn Newbert, Alan Brennan, Jack Joyce, Susan A. Jebb, Paul Aveyard, Nicola Guess, Elizabeth Morris
OBJECTIVE To understand preferences for features of weight loss programs among adults with or at risk of type 2 diabetes in the U.K. RESEARCH DESIGN AND METHODS We conducted a discrete choice experiment with 3,960 U.K. adults living with overweight (n = 675 with type 2 diabetes). Preferences for seven characteristics of weight loss programs were analyzed. Simulations from choice models using the experimental
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Lifetime Duration of Breastfeeding and Cardiovascular Risk in Women With Type 2 Diabetes or a History of Gestational Diabetes: Findings From Two Large Prospective Cohorts Diabetes Care (IF 16.2) Pub Date : 2024-02-20 Anna Birukov, Marta Guasch-Ferré, Sylvia H. Ley, Deirdre K. Tobias, Fenglei Wang, Clemens Wittenbecher, Jiaxi Yang, JoAnn E. Manson, Jorge E. Chavarro, Frank B. Hu, Cuilin Zhang
OBJECTIVE Breastfeeding duration is inversely associated with risks of cardiovascular disease (CVD) and type 2 diabetes in parous women. However, the association among women at high risk, including women with type 2 diabetes or gestational diabetes (GDM) is unclear. RESEARCH DESIGN AND METHODS We included 15,146 parous women with type 2 diabetes from the Nurses’ Health Study I and II (NHS, NHS II)
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Disparities in Sodium–Glucose Cotransporter 2 (SGLT2) Inhibitors Prescription and Dispensing in the Israeli Population—A Retrospective Cohort Study Diabetes Care (IF 16.2) Pub Date : 2024-02-20 Yaara Leibovici Weissman, Bronislava Calvarysky, Tzippy Shochat, Zoya Korotkov, Alon Grossman, Leonard Leibovici, Adi Turjeman
OBJECTIVE To describe disparities in prescribing and dispensing sodium–glucose cotransporter 2 inhibitors (SGLT2i) in Israel. RESEARCH DESIGN AND METHODS This was a population-based retrospective cohort study of adults with type 2 diabetes eligible for SGLT2i treatment from 2017 to 2023. The primary outcome was the time between initial eligibility and the first prescription of SGLT2i. RESULTS Among
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Prevalence and Predictive Factors for Celiac Disease in Children With Type 1 Diabetes. Whom and When to Screen? A Nationwide Longitudinal Cohort Study of Swedish Children Diabetes Care (IF 16.2) Pub Date : 2024-02-16 Marie Lindgren, Fredrik Norström, Martina Persson, Helena Elding Larsson, Gun Forsander, Karin Åkesson, Ulf Samuelsson, Johnny Ludvigsson, Annelie Carlsson
OBJECTIVE To examine the prevalence and predictive factors for celiac disease (CD) after a diagnosis of type 1 diabetes (T1D) in children and adolescents, to improve the current screening guidelines. RESEARCH DESIGN AND METHODS The association between sex, age at T1D diagnosis, HLA, and diabetes autoantibodies, and a diagnosis of CD was examined in 5,295 children with T1D from the Better Diabetes Diagnosis
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Risk of Anaphylaxis Among New Users of GLP-1 Receptor Agonists: A Cohort Study Diabetes Care (IF 16.2) Pub Date : 2024-02-16 Mary S. Anthony, Vanita R. Aroda, Lauren E. Parlett, Leila Djebarri, Sofia Berreghis, Brian Calingaert, Daniel C. Beachler, Christopher L. Crowe, Catherine B. Johannes, Juhaeri Juhaeri, Stephan Lanes, Chunshen Pan, Kenneth J. Rothman, Catherine W. Saltus, Kathleen E. Walsh
OBJECTIVE To assess risk of anaphylaxis among patients with type 2 diabetes mellitus who are initiating therapy with a glucagon-like peptide-1 receptor agonist (GLP-1 RA), with a focus on those starting lixisenatide therapy. RESEARCH DESIGN AND METHODS A cohort study was conducted in three large, U.S. claims databases (2017–2021). Adult (aged ≥18 years) new users of a GLP-1 RA who had type 2 diabetes
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Plant-Based Dietary Patterns and Incident Diabetes in the Atherosclerosis Risk in Communities (ARIC) Study Diabetes Care (IF 16.2) Pub Date : 2024-02-13 Valerie K. Sullivan, Hyunju Kim, Laura E. Caulfield, Lyn M. Steffen, Elizabeth Selvin, Casey M. Rebholz
OBJECTIVE Plant-based dietary patterns emphasize plant foods and minimize animal-derived foods. We investigated the association between plant-based dietary patterns and diabetes in a community-based U.S. sample of Black and White adults. RESEARCH DESIGN AND METHODS We included middle-aged adults from the Atherosclerosis Risk in Communities (ARIC) study without diabetes at baseline who completed a food-frequency
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Erratum. Diabetes in South Asians: Uncovering Novel Risk Factors With Longitudinal Epidemiologic Data: Kelly West Award Lecture 2023. Diabetes Care 2024;47:7–16 Diabetes Care (IF 16.2) Pub Date : 2024-02-09 Alka M. Kanaya
In the article cited above, Fig. 1 contained a mistake for the map of India. The correct image is shown below. The author apologizes for the error. The online version of the article (https://doi.org/10.2337/dci23-0068) has been updated with the correct image.
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Atypical Diabetes: What Have We Learned and What Does the Future Hold? Diabetes Care (IF 16.2) Pub Date : 2024-02-08 Stephen I. Stone, Ashok Balasubramanyam, Jennifer E. Posey
As our understanding of the pathophysiology of diabetes evolves, we increasingly recognize that many patients may have a form of diabetes that does not neatly fit with a diagnosis of either type 1 or type 2 diabetes. The discovery and description of these forms of “atypical diabetes” have led to major contributions to our collective understanding of the basic biology that drives insulin secretion,
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Epidemiology and Prognostic Implications of Coronary Artery Calcium in Asymptomatic Individuals With Prediabetes: A Multicohort Study Diabetes Care (IF 16.2) Pub Date : 2024-02-08 Mahmoud Al Rifai, Mouaz H. Al-Mallah, Michael J. Blaha, Jaideep Patel, John W. McEvoy, Khurram Nasir, Izza Shahid, Kershaw V. Patel, Garima Sharma, Jaume Marrugat, Helena Tizon-Marcos, Raimund Erbel, Andreas Stang, Karl-Heinz Jöckel, Nils Lehmann, Sara Schramm, Börge Schmidt, Roger S. Blumenthal, Salim S. Virani, Vijay Nambi, Miguel Cainzos-Achirica
OBJECTIVE To describe the epidemiology and prognostic value of coronary artery calcium (CAC) in individuals with prediabetes. RESEARCH DESIGN AND METHODS We pooled participants free of clinical atherosclerotic cardiovascular disease (ASCVD) from four prospective cohorts: the Multi-Ethnic Study of Atherosclerosis, Heinz Nixdorf Recall Study, Framingham Heart Study, and Jackson Heart Study. Two definitions
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Longitudinal Changes in Sex Hormone Binding Globulin (SHBG) and Risk of Incident Diabetes: The Study of Women’s Health Across the Nation (SWAN) Diabetes Care (IF 16.2) Pub Date : 2024-02-06 Monique M. Hedderson, Angela Capra, Catherine Lee, Laurel A. Habel, Jennifer Lee, Ellen B. Gold, Sylvia E. Badon, Susanna D. Mitro, Samar R. El Khoudary
OBJECTIVE To investigate the associations of longitudinal changes in sex hormone binding globulin (SHBG) and testosterone (T) over the menopause transition with the risk of diabetes. RESEARCH DESIGN AND METHODS We followed 2,952 participants in the Study of Women’s Health Across the Nation (SWAN) who were premenopausal or early perimenopausal and diabetes-free at baseline. SHBG,T, and estradiol (E2)
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The Efficacy and Safety of Glucagon-Like Peptide-1 Agonists in a Retrospective Study of Patients With Familial Partial Lipodystrophy Diabetes Care (IF 16.2) Pub Date : 2024-02-01 Maria C. Foss-Freitas, Salman Imam, Adam Neidert, Anabela Dill Gomes, David T. Broome, Elif A. Oral
OBJECTIVE Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used for the management of diabetes mellitus (DM), but their efficacy in familial partial lipodystrophy (FPLD) is unknown. In this retrospective study, we evaluated the effect of GLP-1RA in patients with FPLD. RESEARCH DESIGN AND METHODS We analyzed data, reported with SDs, from 14 patients with FPLD (aged 58 ± 12 years; 76.47%
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Severe Hypoglycemia and Impaired Awareness of Hypoglycemia Persist in People With Type 1 Diabetes Despite Use of Diabetes Technology: Results From a Cross-Sectional Survey Diabetes Care (IF 16.2) Pub Date : 2024-01-31 Jennifer L. Sherr, Lori M. Laffel, Jingwen Liu, Wendy Wolf, Jeoffrey Bispham, Katherine S. Chapman, Daniel Finan, Lina Titievsky, Tina Liu, Kaitlin Hagan, Jason Gaglia, Keval Chandarana, Richard Bergenstal, Jeremy Pettus
OBJECTIVE To determine how diabetes technologies, including continuous glucose monitoring (CGM) and automated insulin delivery (AID) systems, impact glycemic metrics, prevalence of severe hypoglycemic events (SHEs), and impaired awareness of hypoglycemia (IAH) in people with type 1 diabetes in a real-world setting within the U.S. RESEARCH DESIGN AND METHODS In this retrospective, observational study
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The Glucose Management Indicator: Time to Change Course? Diabetes Care (IF 16.2) Pub Date : 2024-01-31 Elizabeth Selvin
Laboratory measurement of hemoglobin A1c (HbA1c) has, for decades, been the standard approach to monitoring glucose control in people with diabetes. Continuous glucose monitoring (CGM) is a revolutionary technology that can also aid in the monitoring of glucose control. However, there is uncertainty in how best to use CGM technology and its resulting data to improve control of glucose and prevent complications
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Empagliflozin Reduces Liver Fat in Individuals With and Without Diabetes Diabetes Care (IF 16.2) Pub Date : 2024-01-31 Siham Abdelgani, Ahmed Khattab, John Adams, Gozde Baskoy, Marissa Brown, Geoff Clarke, Olga Larvenenko, Ralph A. DeFronzo, Muhammad Abdul-Ghani
OBJECTIVE To examine the effect of empagliflozin on liver fat content in individuals with and without type 2 diabetes (T2D) and the relationship between the decrease in liver fat and other metabolic actions of empagliflozin. RESEARCH DESIGN AND METHODS Thirty individuals with T2D and 27 without were randomly assigned to receive in double-blind fashion empagliflozin or matching placebo (2:1 ratio) for
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A Real-World Prospective Study of the Effectiveness and Safety of Automated Insulin Delivery Compared With Other Modalities of Type 1 Diabetes Treatment During Ramadan Intermittent Fasting Diabetes Care (IF 16.2) Pub Date : 2024-01-30 Mohammed E. Al-Sofiani, Sahar Alharthi, Sarah Albunyan, Naweed Alzaman, David C. Klonoff, Abdullah Alguwaihes
OBJECTIVE To compare the fasting experience and glycemic control during Ramadan among people with type 1 diabetes (PWT1D) who use automated insulin delivery (AID) versus other modalities of treatment. RESEARCH DESIGN AND METHODS A total of 294 PWT1D who attempted fasting during Ramadan in 2022 were categorized on the basis of treatment modality into one of five groups: 1) AID (n = 62); 2) conventional
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A Novel Variant in the WRN Gene Detected in a Case of Early-Onset Severe Insulin Resistance Displaying Some but Not All Hallmarks of Progeroid Werner Syndrome Diabetes Care (IF 16.2) Pub Date : 2024-01-26 Dominik Spira, Susanne Herbst, Sarina Schwartzmann, Véronique Dutrannoy, Elisabeth Steinhagen-Thiessen, Ilja Demuth, Lukas Maurer, Knut Mai, Joachim Spranger, Stefan Mundlos, Thomas Bobbert
OBJECTIVE Determining the cause of severe insulin resistance and early-onset diabetes in the case of a young woman in which a wide range of differential diagnoses did not apply. RESEARCH DESIGN AND METHODS Diagnostic workup including medical history, physical examination, specialist consultations, imaging methods, laboratory assessment, and genetic testing carried out by next-generation panel sequencing
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Impact of Canagliflozin on Kidney and Cardiovascular Outcomes by Type 2 Diabetes Duration: A Pooled Analysis of the CANVAS Program and CREDENCE trials Diabetes Care (IF 16.2) Pub Date : 2024-01-22 Sheldon W. Tobe, Thomas A. Mavrakanas, Harpreet S. Bajaj, Adeera Levin, Navdeep Tangri, April Slee, Brendon L. Neuen, Vlado Perkovic, Kenneth W. Mahaffey, Wally Rapattoni, Fernando G. Ang
OBJECTIVE The study was undertaken because it was unknown whether the duration of type 2 diabetes modifies the effects of sodium–glucose cotransporter 2 inhibitor canagliflozin on cardiovascular (CV) and kidney outcomes. RESEARCH DESIGN AND METHODS This post hoc analysis of the CANagliflozin cardioVascular Assessment Study (CANVAS) Program (N = 10,142) and Evaluation of the Effects of Canagliflozin
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Clinical Prediction Models Combining Routine Clinical Measures Have High Accuracy in Identifying Youth-Onset Type 2 Diabetes Defined by Maintained Endogenous Insulin Secretion: The SEARCH for Diabetes in Youth Study Diabetes Care (IF 16.2) Pub Date : 2024-01-22 Angus G. Jones, Beverley M. Shields, Richard A. Oram, Dana M. Dabelea, William A. Hagopian, Eva Lustigova, Amy S. Shah, Julieanne Knupp, Amy K. Mottl, Ralph B. D’Agostino, Adrienne Williams, Santica M. Marcovina, Catherine Pihoker, Jasmin Divers, Maria J. Redondo
OBJECTIVE With high prevalence of obesity and overlapping features between diabetes subtypes, accurately classifying youth-onset diabetes can be challenging. We aimed to develop prediction models that, using characteristics available at diabetes diagnosis, can identify youth who will retain endogenous insulin secretion at levels consistent with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS We
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Residential Address Amplifies Health Disparities and Risk of Infection in Individuals With Diabetic Foot Ulcers Diabetes Care (IF 16.2) Pub Date : 2024-01-19 Brian M. Schmidt, Yiyuan Huang, Mousumi Banerjee, Salim S. Hayek, Rodica Pop-Busui
OBJECTIVE To determine the association between social determinants of health (SDOH) and a diagnosis of diabetic foot ulcer (DFU) infection. RESEARCH DESIGN AND METHODS Targeted interrogation of electronic health record data using novel search engines to analyze individuals with a DFU infection during a 5-year period (2013–2017) was performed. We extracted geolocated neighborhood data and SDOH characteristics
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Performance of Artificial Intelligence in Detecting Diabetic Macular Edema From Fundus Photography and Optical Coherence Tomography Images: A Systematic Review and Meta-analysis Diabetes Care (IF 16.2) Pub Date : 2024-01-19 Ching Lam, Yiu Lun Wong, Ziqi Tang, Xiaoyan Hu, Truong X. Nguyen, Dawei Yang, Shuyi Zhang, Jennifer Ding, Simon K.H. Szeto, An Ran Ran, Carol Y. Cheung
BACKGROUND Diabetic macular edema (DME) is the leading cause of vision loss in people with diabetes. Application of artificial intelligence (AI) in interpreting fundus photography (FP) and optical coherence tomography (OCT) images allows prompt detection and intervention. PURPOSE To evaluate the performance of AI in detecting DME from FP or OCT images and identify potential factors affecting model
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Optimal Dose and Type of Physical Activity to Improve Glycemic Control in People Diagnosed With Type 2 Diabetes: A Systematic Review and Meta-analysis Diabetes Care (IF 16.2) Pub Date : 2024-01-19 Daniel Gallardo-Gómez, Eduardo Salazar-Martínez, Rosa M. Alfonso-Rosa, Javier Ramos-Munell, Jesús del Pozo-Cruz, Borja del Pozo Cruz, Francisco Álvarez-Barbosa
BACKGROUND The optimal dose or type of physical activity to control glycosylated hemoglobin (HbA1c) in people with diabetes remains unknown. Current guidelines do not include consideration of baseline HbA1c for activity prescription. PURPOSE To examine the dose-response relationship between physical activity and HbA1c (%) in individuals with type 2 diabetes. DATA SOURCES A systematic search was performed
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A Methodological Framework for Meta-analysis and Clinical Interpretation of Subgroup Data: The Case of Major Adverse Cardiovascular Events With GLP-1 Receptor Agonists and SGLT2 Inhibitors in Type 2 Diabetes Diabetes Care (IF 16.2) Pub Date : 2024-01-19 Thomas Karagiannis, Apostolos Tsapas, Eleni Bekiari, Konstantinos A. Toulis, Michael A. Nauck
We present a methodological framework for conducting and interpreting subgroup meta-analyses. Methodological steps comprised evaluation of clinical heterogeneity regarding the definition of subpopulations, credibility assessment of subgroup meta-analysis, and translation of relative into absolute treatment effects. We used subgroup data from type 2 diabetes cardiovascular outcomes trials (CVOTs) with
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The Specialist Treatment of Inpatients: Caring for Diabetes in Surgery (STOIC-D Surgery) Trial: A Randomized Controlled Trial of Early Intervention With an Electronic Specialist-Led Model of Diabetes Care Diabetes Care (IF 16.2) Pub Date : 2024-01-18 Rahul D. Barmanray, Mervyn Kyi, Peter G. Colman, Lois Rowan, Mayurapriya Raviskanthan, Lucy Collins, Laura Donaldson, Stephanie Montalto, Joshua Tsan, Emily Sun, Minh Le, Leon J. Worth, Benjamin Thomson, Spiros Fourlanos
OBJECTIVE To investigate the effect of early intervention with an electronic specialist-led “proactive” model of care on glycemic and clinical outcomes. RESEARCH DESIGN AND METHODS The Specialist Treatment of Inpatients: Caring for Diabetes in Surgery (STOIC-D Surgery) randomized controlled trial was performed at the Royal Melbourne Hospital. Eligible participants were adults admitted to a surgical
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Association Between Age at Diabetes Diagnosis and Subsequent Incidence of Cancer: A Longitudinal Population-Based Cohort Diabetes Care (IF 16.2) Pub Date : 2024-01-18 Yanyun Li, Jingyan Tian, Tianzhichao Hou, Kai Gu, Qinghua Yan, Siming Sun, Jiange Zhang, Jiao Sun, Lili Liu, Chang-Sheng Sheng, Yi Pang, Minna Cheng, Chunxiao Wu, Katie Harris, Yan Shi, Zachary T. Bloomgarden, John Chalmers, Chen Fu, Guang Ning
OBJECTIVE Diabetes presenting at a younger age has a more aggressive nature. We aimed to explore the association of age at type 2 diabetes mellitus (T2DM) diagnosis with subsequent cancer incidence in a large Chinese population. RESEARCH DESIGN AND METHODS The prospective population-based longitudinal cohort included 428,568 newly diagnosed T2DM patients from 2011 to 2018. Participants were divided
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Interleukin-6, Diabetes, and Metabolic Syndrome in a Biracial Cohort: The Reasons for Geographic and Racial Differences in Stroke Cohort Diabetes Care (IF 16.2) Pub Date : 2024-01-18 Brittney J. Palermo, Katherine S. Wilkinson, Timothy B. Plante, Charles D. Nicoli, Suzanne E. Judd, Debora Kamin Mukaz, D. Leann Long, Nels C. Olson, Mary Cushman
OBJECTIVE Black Americans have a greater risk of type 2 diabetes than White Americans. The proinflammatory cytokine interleukin-6 (IL-6) is implicated in diabetes pathogenesis, and IL-6 levels are higher in Black individuals. This study investigated associations of IL-6 with incident diabetes and metabolic syndrome in a biracial cohort. RESEARCH DESIGN AND METHODS The Reasons for Geographic and Racial
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Impact of the COVID-19 Pandemic on Medical Expenditures Among Medicare Fee-for-Service Beneficiaries Aged ≥67 Years With Diabetes Diabetes Care (IF 16.2) Pub Date : 2024-01-16 Yu Wang, Ping Zhang, Xilin Zhou, Deborah Rolka, Giuseppina Imperatore
OBJECTIVE To compare total and out-of-pocket (OOP) medical expenditures between pre–COVID-19 (March 2019 to February 2020) and COVID-19 (March 2020 to February 2022) periods among Medicare beneficiaries with diabetes. RESEARCH DESIGN AND METHODS Data were from 100% Medicare fee-for-service claims. Diabetes was identified using ICD-10 codes. We calculated quarterly total and OOP medical expenditures
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Pulmonary Function Trajectories Over 6 Years and Their Determinants in Type 2 Diabetes: The Fremantle Diabetes Study Phase II Diabetes Care (IF 16.2) Pub Date : 2024-01-12 Timothy M.E. Davis, Jocelyn J. Drinkwater, Wendy A. Davis
OBJECTIVE To assess whether there are clusters of people with type 2 diabetes with distinct temporal profiles of lung function changes and characteristics. RESEARCH DESIGN AND METHODS Group-based trajectory modeling (GBTM) identified groups of participants with type 2 diabetes from the community-based observational Fremantle Diabetes Study Phase II (FDS2) who had at least two biennial measurements
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Managing Impending Nonsevere Hypoglycemia With Oral Carbohydrates in Type 1 Diabetes: The REVERSIBLE Trial Diabetes Care (IF 16.2) Pub Date : 2024-01-09 Ran Cheng, Nadine Taleb, Zekai Wu, Delphine Bouchard, Valérie Parent, Marie-Laure Lalanne-Mistrih, Valérie Boudreau, Virginie Messier, Marie-Josée Lacombe, Caroline Grou, Anne-Sophie Brazeau, Rémi Rabasa-Lhoret
OBJECTIVE Current guidelines recommend initiating treatment for nonsevere (NS) hypoglycemia with 15 g carbohydrates (CHO) at 15-min intervals when blood glucose (BG) reaches <70 mg/dL (3.9 mmol/L). Despite this recommendation, NS hypoglycemia management remains challenging for individuals living with type 1 diabetes (T1D). We aimed to assess the efficacy of 15 g CHO at higher BG levels. RESEARCH DESIGN
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Modifiable Lifestyle Factors, Genetic Risk, and Incident Peripheral Artery Disease Among Individuals With Type 2 Diabetes: A Prospective Study Diabetes Care (IF 16.2) Pub Date : 2024-01-05 Kai Zhu, Frank Qian, Qi Lu, Rui Li, Zixin Qiu, Lin Li, Ruyi Li, Hancheng Yu, Yulei Deng, Kun Yang, An Pan, Gang Liu
OBJECTIVE To prospectively evaluate the association between modifiable lifestyle factors and peripheral artery disease (PAD) among individuals with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS We included 14,543 individuals with T2D from the UK Biobank. We defined a weighted healthy lifestyle score using nonsmoking, regular physical activity, high-quality diet, moderate alcohol consumption, optimal
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Leisure-Time Physical Activity May Attenuate the Impact of Diabetes on Cognitive Decline in Middle-Aged and Older Adults: Findings From the ELSA-Brasil Study Diabetes Care (IF 16.2) Pub Date : 2024-01-05 Natan Feter, Danilo de Paula, Rodrigo Citton P. dos Reis, David Raichlen, Ana Luísa Patrão, Sandhi Maria Barreto, Claudia Kimie Suemoto, Bruce B. Duncan, Maria Inês Schmidt
OBJECTIVE To assess leisure-time physical activity (LTPA) as a modifier of the diabetes/cognitive decline association in middle-aged and older participants in the Estudo Longitudinal de Saude do Adulto (ELSA-Brasil) study. RESEARCH DESIGN AND METHODS ELSA-Brasil is a cohort of 15,105 participants (age 35–74 years) enrolled between 2008 and 2010. We evaluated global cognitive function, summing the scores
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Low-Dose Colchicine in Patients With Type 2 Diabetes and Recent Myocardial Infarction in the COLchicine Cardiovascular Outcomes Trial (COLCOT) Diabetes Care (IF 16.2) Pub Date : 2024-01-05 François Roubille, Nadia Bouabdallaoui, Simon Kouz, David D. Waters, Rafael Diaz, Aldo P. Maggioni, Fausto J. Pinto, Jean C. Grégoire, Habib Gamra, Ghassan S. Kiwan, Colin Berry, José López-Sendón, Wolfgang Koenig, Laurent Delorme, Meyer Elbaz, Pierre Coste, Mylène Provencher, Zohar Bassevitch, Lucie Blondeau, Philippe L. L’Allier, Marie-Claude Guertin, Jean-Claude Tardif
OBJECTIVE The cardiovascular benefits of low-dose colchicine have been demonstrated in patients with coronary disease. Its effects were evaluated in this prespecified analysis in patients with type 2 diabetes (T2D) from the COLchicine Cardiovascular Outcomes Trial (COLCOT). RESEARCH DESIGN AND METHODS COLCOT was a randomized, double-blinded trial of colchicine, 0.5 mg daily, versus placebo initiated
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Pathogenic, Total Loss-of-Function DYRK1B Variants Cause Monogenic Obesity Associated With Type 2 Diabetes Diabetes Care (IF 16.2) Pub Date : 2024-01-03 Lise Folon, Morgane Baron, Victoria Scherrer, Bénédicte Toussaint, Emmanuel Vaillant, Hélène Loiselle, Aurélie Dechaume, Frédérique De Pooter, Raphaël Boutry, Mathilde Boissel, Aboubacar Diallo, Lijiao Ning, Beverley Balkau, Guillaume Charpentier, Sylvia Franc, Michel Marre, Mehdi Derhourhi, Philippe Froguel, Amélie Bonnefond
OBJECTIVE Rare variants in DYRK1B have been described in some patients with central obesity, type 2 diabetes, and early-onset coronary disease. Owing to the limited number of conducted studies, the broader impact of DYRK1B variants on a larger scale has yet to be investigated. RESEARCH DESIGN AND METHODS DYRK1B was sequenced in 9,353 participants from a case-control study for obesity and type 2 diabetes
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Risk Assessment for Gastrointestinal Diseases via Clinical Dimension and Genome-Wide Polygenic Risk Scores of Type 2 Diabetes: A Population-Based Cohort Study Diabetes Care (IF 16.2) Pub Date : 2024-01-02 Tian Fu, Yuhao Sun, Shiyuan Lu, Jianhui Zhao, Lintao Dan, Wenming Shi, Jie Chen, Yan Chen, Xue Li
OBJECTIVE We aimed to evaluate whether individuals with type 2 diabetes (T2D) were at higher risk of developing a wide range of gastrointestinal diseases based on a population-based cohort study. RESEARCH DESIGN AND METHODS This study included 374,125 participants free of gastrointestinal disorders at baseline; of them, 19,719 (5.27%) with T2D were followed-up by linking to multiple medical records
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Plasma miRNAs and Treatment Failure in Participants in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study Diabetes Care (IF 16.2) Pub Date : 2023-12-28 Pandora L. Wander, Theo K. Bammler, James W. MacDonald, Sengeo Srinouanprachanh, Edward J. Boyko, Daniel A. Enquobahrie
OBJECTIVE To identify plasma miRNAs related to treatment failure in youth with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS We examined whether a panel of miRNAs could predict treatment failure in training/test data sets among participants in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study (N = 209). We also examined whether individual miRNAs were associated with