样式: 排序: IF: - GO 导出 标记为已读
-
Cardiac dysfunction in sucrose-fed rats is associated with alterations of phospholamban phosphorylation and TNF-α levels Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-04-10 Cristina Schmitt Gregolin, Milena do Nascimento, Sérgio Luiz Borges de Souza, Gustavo Augusto Ferreira Mota, Renata de Azevedo Melo Luvizotto, Mário Mateus Sugizaki, Silméia Garcia Zanati Bazan, Dijon Henrique Salomé de Campos, Camila Renata Corrêa Camacho, Antonio Carlos Cicogna, André Ferreira do Nascimento
-
Sexual Dimorphism's impact on adipogenesis: A three-dimensional in vitro model treated with 17β-estradiol and testosterone Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-04-09 Pallabi Pal, Rodrigo O. Maranon, Osvaldo J. Rivera Gonzales, Joshua S. Speed, Amol V. Janorkar
Using a three-dimensional (3-D) culture model, we report the dose dependent effect of 17β-estradiol and testosterone on the adipogenic differentiation and maturation of human adipose derived stem cells (hASCs) obtained from female and male patients. Considering sexual dimorphism, we expected male and female adipocytes to respond differently to the sex steroids. Both male and female hASC spheroids were
-
Developmental programming: Testosterone excess masculinizes female pancreatic transcriptome and function in sheep Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-04-06 Katherine M. Halloran, Nadia Saadat, Brooke Pallas, Arpita K. Vyas, Robert Sargis, Vasantha Padmanabhan
Hyperandrogenic disorders, such as polycystic ovary syndrome, are often associated with metabolic disruptions such as insulin resistance and hyperinsulinemia. Studies in sheep, a precocial model of translational relevance, provide evidence that exposure to excess testosterone during days 30–90 of gestation (the sexually dimorphic window where males naturally experience elevated androgens) programs
-
Liraglutide promotes UCP1 expression and lipolysis of adipocytes by promoting the secretion of irisin from skeletal muscle cells Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-04-01 Nan Zhang, Heng Zhou, Yijing Xu, Yi Zhang, Fangmei Yu, Li Gui, Qiu Zhang, Yunxia Lu
-
Photoperiod, but not progesterone, has a strong impact upon the transcriptome of the medio-basal hypothalamus in female goats and ewes Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-03-30 Hugues Dardente, Didier Lomet, Vincent Robert, Olivier Lasserre, Anne-Alicia Gonzalez, Xavier Mialhe, Massimiliano Beltramo
-
Maternal malnutrition associated with postnatal sugar consumption increases inflammatory response and prostate disorders in rat offspring Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-03-29 Matheus Naia Fioretto, Ketlin Thassiani Colombelli, Cecilia Luvizutti Ferreira da Silva, Sérgio Alexandre Alcantara dos Santos, Ana Carolina Lima Camargo, Flávia Bessi Constantino, Luiz Marcos Frediani Portela, Ariana Musa de Aquino, Luisa Annibal Barata, Renato Mattos, Wellerson Rodrigo Scarano, Elena Zambrano, Luis Antonio Justulin
-
Exosomes from adipose-derived mesenchymal stem cell improve diabetic wound healing and inhibit fibrosis via miR-128-1-5p/TGF-β1/Smad axis Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-03-29 Qiu Liang, Danlian Zhou, Xiuyu Ge, Peijun Song, Weiwei Chu, Jing Xu, Yan Shen
-
Developmental programming: An exploratory analysis of pancreatic islet compromise in female sheep resulting from gestational BPA exposure Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-03-27 Joseph Ciarelli, Soundara Viveka Thangaraj, Haijing Sun, Stephanie Domke, Bashar Alkhatib, Arpita Kalla Vyas, Brigid Gregg, Robert M. Sargis, Vasantha Padmanabhan
-
Insulin signaling and mitochondrial phenotype of skeletal muscle are programmed in utero by maternal diabetes Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-03-27 Eduardo Klöppel, Larissa L. Cruz, Laura F.L. Prado-Souza, Adam Eckhardt, José E. Corrente, Daniela C. dos Santos, Luís A. Justulin, Tiago Rodrigues, Gustavo T. Volpato, Débora C. Damasceno
Maternal diabetes may influence glucose metabolism in adult offspring, an area with limited research on underlying mechanisms. Our study explored the impact of maternal hyperglycemia during pregnancy on insulin resistance development. Adult female Sprague-Dawley rats from control and diabetic mothers were mated, and their female offspring were monitored for 150 days. The rats were euthanized for blood
-
Neuroendocrine functions of monoamines in invertebrates: Focus on bivalve molluscs Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-03-26 Elena Fabbri, Teresa Balbi, Laura Canesi
Monoamines (MA) such as serotonin, catecholamines (dopamine, norepinephrine, epinephrine), and trace amines (octopamine, tyramine), are neurotransmitters and neuroendocrine modulators in vertebrates, that contribute to adaptation to the environment. Although MA are conserved in evolution, information is still fragmentary in invertebrates, given the diversity of phyla and species. However, MA are crucial
-
Elevated chorionic gonadotropic hormone in transgenic mice induces parthenogenetic activation and ovarian teratomas Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-03-26 Susana B. Rulli, Petteri Ahtiainen, Laura D. Ratner, Kim Jonas, Ricardo S. Calandra, Matti Poutanen, Ilpo Huhtaniemi
Both male and female reproductive functions are impacted by altered gonadotrophin secretion and action, which may also influence the development of endocrine tumours. To ascertain if chronic hypersecretion of human chorionic gonadotropin (hCG) contributes to the development of gonadal tumours, double transgenic (TG) mice that overexpress hCGα- and β-subunits were analysed. By the age of two months
-
Diverse genetic causes of amenorrhea in an ethnically homogeneous cohort and an evolving approach to diagnosis Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-03-22 Shabnam Bakhshalizadeh, Fateme Afkhami, Katrina M. Bell, Gorjana Robevska, Jocelyn van den Bergen, Sara Cronin, Sylvie Jaillard, Katie L. Ayers, Pramod Kumar, Christian Siebold, Zhangping Xiao, Edward W. Tate, Shahla Danaei, Laya Farzadi, Shirin Shahbazi, Andrew H. Sinclair, Elena J. Tucker
Premature ovarian insufficiency (POI) is characterised by amenorrhea associated with elevated follicle stimulating hormone (FSH) under the age of 40 years and affects 1–3.7% women. Genetic factors explain 20–30% of POI cases, but most causes remain unknown despite genomic advancements. We used whole exome sequencing (WES) in four Iranian families, validated variants via Sanger sequencing, and conducted
-
16α-OHE1 alleviates hypoxia-induced inflammation and myocardial damage via the activation of β2-Adrenergic receptor Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-03-20 Yequan Zhou, Zeyuan Yin, Junchao Cui, Cheng Wang, Tong Fu, Joseph Adu-Amankwaah, Lu Fu, Xueyan Zhou
Myocardial injuries resulting from hypoxia are a significant concern, and this study aimed to explore potential protective strategies against such damage. Specifically, we sought to investigate the cardioprotective effects of 16α-hydroxyestrone (16α-OHE1). Male Sprague‒Dawley (SD) rats were subjected to hypoxic conditions simulating high-altitude exposure at 6000 m in a low-pressure chamber for 7 days
-
Intestinal alterations and mild glucose homeostasis impairments in the offspring born to overweight rats Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-03-16 Florencia Heinecke, Daiana Fornes, Evangelina Capobianco, Jeremias Pablo Flores Quiroga, Marina Labiano, Alicia G Faletti, Alicia Jawerbaum, Verónica White
-
Endocrine factors modulating vitellogenesis and oogenesis in insects: An update Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-03-15 Jimena Leyria
The endocrine system plays a pivotal role in shaping the mechanisms that ensure successful reproduction. With over a million known insect species, understanding the endocrine control of reproduction has become increasingly complex. Some of the key players include the classic insect lipid hormones juvenile hormone (JH) and ecdysteroids, and neuropeptides such as insulin-like peptides (ILPs). Individual
-
Single microcystin exposure impairs the hypothalamic-pituitary-gonadal axis at different levels in female rats Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-03-13 Flavia C.F. Dos Santos, Gabriela F.C. Lima, Eduardo Merlo, Cidalia de F. Januario, Leandro Miranda-Alves, Rosiane A. Miranda, Patrícia C. Lisboa, Jones B. Graceli
-
Uterine histopathology and steroid metabolism in a polycystic ovary syndrome rat model Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-03-11 Gisela Soledad Bracho, María Virginia Acosta, Gabriela Anahí Altamirano, Mirta Raquel Alcaraz, Milagros Montemurro, María Julia Culzoni, María Florencia Rossetti, Laura Kass, Enrique Hugo Luque, Verónica Lis Bosquiazzo
The aim of this study was to investigate uterine lesions, uterine endocrine status and expression of genes involved in uterine differentiation in a rat model of polycystic ovary syndrome (PCOS). The possible involvement of the androgen receptor (AR) was also investigated. PCOS rats showed an increased incidence of uterine epithelial and glandular lesions and elevated serum testosterone level, which
-
Association between nitric oxide synthase (NOS3) gene polymorphisms and diabetic nephropathy: An updated meta-analysis Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-03-08 Zorana Dobrijević, Jovana Stevanović, Dragana Robajac, Ana Penezić, Danilo Četić, Marko Baralić, Olgica Nedić
-
Autophagy inhibition suppresses hormone production and cell growth in pituitary tumor cells: A potential approach to pituitary tumors Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-03-08 Motoyasu Satou, Jason Wang, Tae Nakano-Tateno, Mariko Teramachi, Shigeki Aoki, Hiroyuki Sugimoto, Constance Chik, Toru Tateno
Pituitary tumors (PTs) represent about 10% of all intracranial tumors, and most are benign. However, some PTs exhibit continued growth despite multimodal therapies. Although temozolomide (TMZ), an alkylating chemotherapeutic agent, is a first-line medical treatment for aggressive PTs, some PTs are resistant to TMZ. Existing literature indicated the involvement of autophagy in cell growth in several
-
Excess homocysteine inhibits pancreatic β-cell secretory function by repressing Zbtb20 expression Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-03-01 Tianqi Ding, Bo Wen, Jian Chen, Wenbin Chu, Rong Fan, Xuewei Chen
Homocysteine (Hcy) is a sulfur-containing amino acid. An elevated level of Hcy is a risk factor for diabetes development. However, the mechanism of its effect on pancreatic β-cell function is unclear. In this study, we constructed a hyperhomocysteinemia (HHcy) mouse model by feeding mice a high methionine diet (HMD). The mice suffered impaired glucose tolerance and reduced insulin secretion. Furthermore
-
Revisiting the evolution of Family B1 GPCRs and ligands: Insights from mollusca Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-02-24 João C.R. Cardoso, Jennifer C. Mc Shane, Zhi Li, Maoxiao Peng, Deborah M. Power
Family B1 G protein-coupled receptors (GPCRs) are one of the most well studied neuropeptide receptor families since they play a central role in many biological processes including endocrine, gastrointestinal, cardiovascular and reproduction in animals. The genes for these receptors emerged from a common ancestral gene in bilaterian genomes and evolved via gene/genome duplications and deletions in vertebrate
-
Intestinal remodeling during Xenopus metamorphosis as a model for studying thyroid hormone signaling and adult organogenesis Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-02-22 Yun-Bo Shi, Liezhen Fu, Yuta Tanizaki
Intestinal development takes places in two phases, the initial formation of neonatal (mammals)/larval (anurans) intestine and its subsequent maturation into the adult form. This maturation occurs during postembryonic development when plasma thyroid hormone (T3) level peaks. In anurans such as the highly related and , the larval/tadpole intestine is drastically remodeled from a simple tubular structure
-
Deficiency of nucleosome-destabilizing factor GLYR1 dampens spermatogenesis in mice Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-02-21 Gui-ping Cheng, Yu-fan Wang, Yuan-yuan Li, Shi-meng Guo, Hong-gang Li, Dong-mei Ji, Nian-hua Yi, Li-quan Zhou
Aberrant sperm morphology hinders sperm motility and causes male subfertility. Spermatogenesis, a complex process in male germ cell development, necessitates precise regulation of numerous developmental genes. However, the regulatory pathways involved in this process remain partially understood. We have observed the widespread expression of , the gene encoding a nucleosome-destabilizing factor, in
-
The Caenorhabditis elegans neuroendocrine system and their modulators: An overview Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-02-20 Daniela Teixeira Rodrigues, Heloísa Aiolfi Padilha, Ana Thalita Gonçalves Soares, Maria Eduarda Oliveira de Souza, Matteus Teixeira Guerra, Daiana Silva Ávila
In this review we seek to systematically bring what has been published in the literature about the nervous system, endocrine system, neuroendocrine relationships, neuroendocrine modulations and endocrine disruptors in the alternative model . The serotonergic, dopaminergic, GABAergic and glutamatergic neurotransmitters are related to the modulation of the neuroendocrine axis, leading to the activation
-
Npy transcription is regulated by noncanonical STAT3 signaling in hypothalamic neurons: Implication with lipotoxicity and obesity Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-02-20 Wenyuan He, Neruja Loganathan, Andy Tran, Denise D. Belsham
Neuropeptide Y () is an abundant neuropeptide expressed in the central and peripheral nervous systems. NPY-secreting neurons in the hypothalamic arcuate nucleus regulate energy homeostasis, and mRNA expression is regulated by peripheral nutrient and hormonal signals like leptin, interleukin-6 (IL-6), and fatty acids. This study demonstrates that IL-6, which phosphorylates tyrosine 705 (Y705) of STAT3
-
Anti-steatotic effects of PPAR-alpha and gamma involve gut-liver axis modulation in high-fat diet-fed mice Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-02-17 Isabela Macedo Lopes Vasques-Monteiro, Aline Fernandes-da-Silva, Carolline Santos Miranda, Flavia Maria Silva-Veiga, Julio Beltrame Daleprane, Vanessa Souza-Mello
To evaluate the effects of PPARα and PPARγ activation (alone or in combination) on the gut-liver axis, emphasizing the integrity of the intestinal barrier and hepatic steatosis in mice fed a high saturated fat diet. Male C57BL/6J were fed a control diet (C) or a high-fat diet (HF) for ten weeks. Then, a four-week treatment started: HF-α (WY14643), HF-γ (low-dose pioglitazone), and HF-αγ (combination)
-
Growth differentiation factor-11 upregulates matrix metalloproteinase 2 expression by inducing Snail in human extravillous trophoblast cells Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-02-16 Ze Wu, Qian Zhang, Hailong Wang, Shenghui Zhou, Bingxin Fu, Lanlan Fang, Jung-Chien Cheng, Ying-Pu Sun
The human extravillous trophoblast (EVT) cell invasion is an important process during placentation. Although the placenta is normal tissue, the EVT cells exhibit some features common to cancer cells, including high migratory and invasive properties. Snail and Slug are transcription factors that mediate the epithelial-mesenchymal transition (EMT), a crucial event for cancer cell migration and invasion
-
Endocrine disruption in crustaceans: New findings and perspectives Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-02-15 Enrique M. Rodríguez
A significant advance has been made, especially during the last two decades, in the knowledge of the effects on crustacean species of pollutants proven to be endocrine disruptors in vertebrates. Such effects have been also interpreted in the light of recent studies on crustacean endocrinology. Year after year, the increased number of reports refer to the effects of endocrine disruptors on several processes
-
-
C. elegans insulin-like peptides Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-02-10 Rain Zhu, Ian D. Chin-Sang
-
Participation of follicular superoxides, inflammatory modulators, and endocrine factors in zebrafish (Danio rerio) ovulation: Cross-talk between PKA and MAPK signaling in Pgr regulation of ovulatory markers Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-02-10 Soumyajyoti Ghosh, Subhasri Biswas, Urmi Mukherjee, Sampurna Karmakar, Sudipta Maitra
-
Untangling the gordian knot: The intertwining interactions between developmental hormone signaling and epigenetic mechanisms in insects Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-02-09 Bart Geens, Stijn Goossens, Jia Li, Yves Van de Peer, Jozef Vanden Broeck
Hormones control developmental and physiological processes, often by regulating the expression of multiple genes simultaneously or sequentially. Crosstalk between hormones and epigenetics is pivotal to dynamically coordinate this process. Hormonal signals can guide the addition and removal of epigenetic marks, steering gene expression. Conversely, DNA methylation, histone modifications and non-coding
-
Hyperbaric oxygen preconditioning normalizes scrotal temperature, sperm quality, testicular structure, and erectile function in adult male rats subjected to exertional heat injury Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-02-09 Kun-Lin Hsieh, Tzong-Bor Sun, Kuan-Hua Huang, Cheng-Hsien Lin, Ling-Yu Tang, Chien-Liang Liu, Chien-Ming Chao, Ching-Ping Chang
Testicular hyperthermia has been noted in men who work in high ambient temperatures. Scrotal temperatures above the normal range caused germ cell loss in the testes and resulted in male subfertility. In adult male rats, exercising at a higher environmental temperature (36 °C with relative humidity of 50%, 52 min) caused exertional heat stroke (EHS) characterized by scrotal hyperthermia, impaired sperm
-
Chronic activation of adrenal Gq signaling induces Cyp11b2 expression in the zona fasciculata and hyperaldosteronism Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-02-08 Desmaré van Rooyen, Antonio M. Lerario, Donald W. Little III, Matthew R. Ullenbruch, Matthew J. Taylor, Celso E. Gomez-Sanchez, Gary D. Hammer, William E. Rainey
Hyperaldosteronism is often associated with inappropriate aldosterone production and aldosterone synthase (Cyp11b2) expression. Normally, Cyp11b2 expression is limited to the adrenal zona glomerulosa (ZG) and regulated by angiotensin II which signals through Gq protein-coupled receptors. As cells migrate inwards, they differentiate into 11β-hydroxylase-expressing zona fasciculata (ZF) cells lacking
-
-
Dichloroacetate ameliorates apoptosis, EMT and oxidative stress in diabetic cataract via inhibiting the IDO1-dependent p38 MAPK pathway Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-01-30 Guang-ming Liu, Mengting Shao, Yan Liu
As an oral antidiabetic agent, dichloroacetate (DCA) has been proven to improve diabetes and related complications. However, its functional role in diabetic cataract (DC) remains to be elucidated. This study was to define the role of DCA and its underlying molecular mechanism in DC and . In this study, it was shown that DCA dose-dependently ameliorated DC formation and development in DM rats. In addition
-
Evolutionary conserved peptide and glycoprotein hormone-like neuroendocrine systems in C. elegans Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-01-28 Majdulin Nabil Istiban, Nathan De Fruyt, Signe Kenis, Isabel Beets
Peptides and protein hormones form the largest group of secreted signals that mediate intercellular communication and are central regulators of physiology and behavior in all animals. Phylogenetic analyses and biochemical identifications of peptide-receptor systems reveal a broad evolutionary conservation of these signaling systems at the molecular level. Substantial progress has been made in recent
-
CTRP9 prevents atherosclerosis progression through changing autophagic status of macrophages by activating USP22 mediated-de-ubiquitination on Sirt1 in vitro Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-01-26 Min Zeng, Yali Yang, Ziyan Wang, Xiuyang Zhao, Dianshu Zhu, Mengdi Wang, Yue Chen, Xin Wei
Atherosclerosis (AS) is commonly regarded as a key driver accounted for the leading causes of morbidity and mortality among cardiovascular and cerebrovascular diseases. A growing body of evidence indicates that autophagy in macrophages involved in AS might be a potential therapeutic target. C1q/TNF-related protein 9 (CTRP9) has been proven to delay the progression of cardiovascular diseases. However
-
SGLT2 knockdown restores the Th17/Treg balance and suppresses diabetic nephropathy in db/db mice by regulating SGK1 via Na+ Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-01-24 Dan Wang, Qian Zhang, Wenhui Dong, Shijing Ren, Xiangyu Wang, Cailin Su, Xiaochun Lin, Zongji Zheng, Yaoming Xue
The imbalance between T helper 17 (Th17) and regulatory T (Treg) cells is an important mechanism in the pathogenesis of diabetic nephropathy (DN). Serum/glucocorticoid regulated kinase 1 (SGK1) is a serine-threonine kinase critical for stabilizing the Th17 cell phenotype. Sodium-glucose cotransporter 2 (SGLT2) is a glucose transporter that serves as a treatment target for diabetes. Our study investigated
-
Leptin- and cytokine-like unpaired signaling in Drosophila Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-01-23 Meet Zandawala, Jayati Gera
Animals have evolved a multitude of signaling pathways that enable them to orchestrate diverse physiological processes to tightly regulate systemic homeostasis. This signaling is mediated by various families of peptide hormones and cytokines that are conserved across the animal kingdom. In this review, we primarily focus on the unpaired (Upd) family of proteins in which are evolutionarily related to
-
PMM2 controls ERα levels and cell proliferation in ESR1 Y537S variant expressing breast cancer cells Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-01-22 Manuela Cipolletti, Filippo Acconcia
Metabolic reprogramming in breast cancer (BC) subtypes offers potential personalized treatment targets. Estrogen receptor α (ERα)-positive BC patients undergoing endocrine therapy (ET) can develop ET-resistant metastatic disease. Specific mutations, like Y537S in ERα, drive uncontrolled cell proliferation. Targeting mutant receptor levels shows promise for inhibiting growth in metastatic BC expressing
-
Branched-chain amino acids promote occurrence and development of cardiovascular disease dependent on triglyceride metabolism via activation of the mTOR/SREBP-1/betatrophin pathway Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-01-21 Jie Zhang, Ziyu Liu, Yaojun Ni, Yang Yu, Fei Guo, Yanwen Lu, Xiaoqing Wang, Hairong Hao, Shayan Li, Pan Wei, Weinan Yu, Wen Hu
Branched-chain amino acid (BCAA) metabolism is associated with triglyceride (TG) metabolism and the development of cardiovascular disease (CVD). However, the underlying mechanism remains uncertain. This study included 1302 subjects and followed for 4–5 years. A hyperbranched-chain aminoacidemia rat model was induced by high fructose diet (HFTD). The relationship between BCAAs and TG level and its regulatory
-
Glycoprotein hormone subunit alpha 2 (GPHA2): A pituitary stem cell-expressed gene associated with NOTCH2 signaling Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-01-20 Xiyu Ge, Karen Weis, Lori Raetzman
NOTCH2 is expressed in pituitary stem cells and is necessary for stem cell maintenance, proliferation, and differentiation. However, the pathways NOTCH2 engages to affect pituitary development remain unclear. In this study, we hypothesized that glycoprotein hormone subunit A2 (GPHA2), a corneal stem cell factor and ligand for the thyroid stimulating hormone receptor (TSHR), is downstream of NOTCH2
-
Retraction notice to “Effect of steviol, steviol glycosides and stevia extract on glucocorticoid receptor signaling in normal and cancer blood cells” [Mol. Cell. Endocrinol. 460 (15 January 2018) 189–199] Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-01-18 Christina Panagiotou, Chrysovalantou Mihailidou, George Brauhli, Olga Katsarou, Paraskevi Moutsatsou
Abstract not available
-
Retraction notice to “Crosstalk between C/EBP homologous protein (CHOP) and glucocorticoid receptor in lung cancer” [Mol. Cell. Endocrinol. 436 (2016) 211–223] Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-01-18 Chrysovalantou Mihailidou, Christina Panagiotou, Hippokratis Kiaris, Eva Kassi, Paraskevi Moutsatsou
Abstract not available
-
Computational drug repurposing for primary hyperparathyroidism Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-01-14 Elif Kubat Öktem, Metin Yazar, Erhan Aysan, Özge Karabıyık Acar
-
Thyrotropin induces atherosclerosis by upregulating large conductance Ca2+-activated K+ channel subunits Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-01-05 Linjun Xie, Qian You, Jingying Mao, Fei Wu, Chengwei Xia, Rui Hai, Yan Wei, Xiangyu Zhou
Hypothyroidism is associated with elevated levels of serum thyrotropin (TSH), which have been shown to promote abnormal proliferation of vascular smooth muscle cells and contribute to the development of atherosclerosis. However, the specific mechanisms underlying the TSH-induced abnormal proliferation of vascular smooth muscle cells remain unclear. The objective of this study was to investigate the
-
-
Antidepressants – The new endocrine disruptors? The case of crustaceans Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2024-01-06 Thomas Knigge
Antidepressants are high-volume pharmaceuticals that accumulate to concentrations in the μg·L−1 range in surface waters. The release of peptide hormones via neurosecretory cells appears as a natural target for antidepressants. Here I review research that suggests that antidepressants indeed disrupt endocrine signalling in crustaceans, by acting on the synthesis and release of neurohormones, such as
-
Decoding the role of microRNA dysregulation in the interplay of pancreatic cancer and type 2 diabetes Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2023-12-29 María Victoria Mencucci, Martín Carlos Abba, Bárbara Maiztegui
-
Direct in vitro action of estrone on uterine and white adipose tissue in obesity Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2023-12-26 María Ivone Valle, Pablo H. Cutini, Sabrina B. Cepeda, Adrián E. Campelo, Marisa J. Sandoval, Virginia L. Massheimer
The hypothesis whether estrone (E1) could exhibit a direct action at uterus and white adipose tissue (WAT), under obesity was tested. In uterine tissue of obese rats, E1 increased nitric oxide (NO) synthesis, and reduced reactive oxygen species (ROS) production. The anti-oxidative action of E1 was sustained under inflammatory stress or high glucose levels. ICI 182780 or G15 compounds were employed
-
Metformin inhibits cell proliferation and ACTH secretion in AtT20 cells via regulating the MAPK pathway Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2023-12-24 Yingxuan Sun, Jianhua Cheng, Ding Nie, Qiuyue Fang, Chuzhong Li, Yazhuo Zhang
We investigated the impact of metformin on ACTH secretion and tumorigenesis in pituitary corticotroph tumors. The mouse pituitary tumor AtT20 cell line was treated with varying concentrations of metformin. Cell viability was assessed using the CCK-8 assay, ACTH secretion was measured using an ELISA kit, changes in the cell cycle were analyzed using flow cytometry, and the expression of related proteins
-
Pressures of the urban environment on the endocrine system: Adverse effects and adaptation Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2023-12-24 Patricia Rannaud-Bartaire, Barbara A. Demeneix, Jean-Baptiste Fini
With an increasing collective awareness of the rapid environmental changes, questions and theories regarding the adaptability of organisms are emerging. Global warming as well as chemical and non-chemical pollution have been identified as triggers of these adaptative changes, but can we link different kinds of stressors to certain phenotypic traits? The physiological adaptation, and particularly endocrine
-
Effects of carnosine supplementation on markers for the pathophysiological development of metabolic dysfunction-associated steatotic liver disease in a diet-induced model Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2023-12-24 Núbia Alves Grandini, Mariane Róvero Costa, Cristina Schmitt Gregolin, Juliana Silva Siqueira, Taynara Aparecida Vieira, Artur Junio Togneri Ferron, Fabiane Valentini Francisqueti-Ferron, Guilherme Ribeiro Romualdo, Ana Lúcia dos Anjos Ferreira, Giancarlo Aldini, Camila Renata Corrêa, Fernando Moreto
Consumption of diets high in sugar and fat is related to the development of Metabolic dysfunction-associated steatotic liver disease (MASLD). Carnosine (CAR) is a dipeptide with antioxidant and anti-inflammatory action and has been studied for treating diseases. This work aimed to evaluate the effects of CAR on diet-induced MASLD in rats. Male Wistar rats were distributed into 2 groups (17 weeks):
-
Editorial Urban Endocrinology Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2023-12-21 Natacha Roux, Vincent Laudet
Abstract not available
-
Endocrine tumors of the female reproductive tract Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2023-12-20 Sylvia L. Asa, Shereen Ezzat
Endocrine cells responsible for hormone secretion are found in virtually every organ system. The diverse neoplasms arising from endocrine cells in the female reproductive tract are not well recognized as a distinct component of endocrine oncology. Here, we integrate cellular origins with native anatomical residence to help classify neoplasms of this system. The neoplasms include steroidogenic tumors
-
FOXO1 regulates expression of Neurod4 in the pituitary gland Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2023-12-22 Caitlin E. Stallings, Pratyusa Das, Sandria W. Athul, Arnold E. Ukagwu, Philip J. Jensik, Buffy S. Ellsworth
-
Canagliflozin improves fatty acid oxidation and ferroptosis of renal tubular epithelial cells via FOXA1-CPT1A axis in diabetic kidney disease Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2023-12-19 Tian Gan, Qingzhu Wang, Yi Song, Mingwei Shao, Yanyan Zhao, Feng Guo, Fangyi Wei, Xunjie Fan, Wei Zhang, Yuanyuan Luo, Duo Chen, Shanshan Wang, Guijun Qin
-
Dissection of an impact of VDR and RXRA on the genomic activity of 1,25(OH)2D3 in A431 squamous cell carcinoma Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2023-12-19 Anna M. Olszewska, Joanna I. Nowak, Kamil Myszczynski, Andrzej Słominski, Michał A. Żmijewski
Background Human skin is the natural source, place of metabolism, and target for vitamin D3. The classical active form of vitamin D3, 1,25(OH)2D3, expresses pluripotent properties and is intensively studied in cancer prevention and therapy. To define the specific role of vitamin D3 receptor (VDR) and its co-receptor retinoid X receptor alpha (RXRA) in genomic regulation, VDR or RXRA genes were silenced
-
Bone morphogenetic protein-9 downregulates StAR expression by inducing snail expression via SMAD1/5/8 signaling in human granulosa-lutein cells Mol. Cell. Endocrinol. (IF 4.1) Pub Date : 2023-12-16 Boqun Liu, Bingxin Fu, Shenghui Zhou, Hailong Wang, Beibei Bi, Manman Guo, Jung-Chien Cheng, Lanlan Fang
Ovarian steroidogenesis mediated by granulosa cells is pivotal in maintaining normal female reproductive function. The steroidogenic acute regulatory protein (StAR) regulates the rate-limiting step in steroidogenesis. Bone morphogenetic protein-9 (BMP-9), also known as growth differentiation factor-2 (GDF-2), is a member of the transforming growth factor-beta (TGF-β) superfamily. BMP-9 induces epithelial-mesenchymal