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Interpretable machine learning-based clinical prediction model for predicting lymph node metastasis in patients with intrahepatic cholangiocarcinoma BMC Gastroenterol. (IF 2.4) Pub Date : 2024-04-19 Hui Xie, Tao Hong, Wencai Liu, Xiaodong Jia, Le Wang, Huan Zhang, Chan Xu, Xiaoke Zhang, Wen-Le Li, Quan Wang, Chengliang Yin, Xu Lv
Prediction of lymph node metastasis (LNM) for intrahepatic cholangiocarcinoma (ICC) is critical for the treatment regimen and prognosis. We aim to develop and validate machine learning (ML)-based predictive models for LNM in patients with ICC. A total of 345 patients with clinicopathological characteristics confirmed ICC from Jan 2007 to Jan 2019 were enrolled. The predictors of LNM were identified
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Downregulation of lncRNA EPB41L4A-AS1 promotes gastric cancer cell proliferation, migration and invasion BMC Gastroenterol. (IF 2.4) Pub Date : 2024-04-16 Jiancang Ma, Yingying Feng, Jinkai Xu, Zongyu Li, Jingyue Lai, Hao Guan
The incidence of gastric cancer ranks the first among digestive tract tumors in China. However, there are no specific symptoms in the early stage of the tumor and the diagnosis process is complex, so more effective detection methods are very needed. In this study, a novel long noncoding RNA (lncRNA) was introduced as a diagnostic biomarker for gastric cancer, which brought new thinking to the exploration
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Level of interleukin 17 in inflammatory bowel disease and its relation with disease activity BMC Gastroenterol. (IF 2.4) Pub Date : 2024-04-15 Ayman Menesy, Mohamed Hammad, Salah Aref, Fatma Adel Mourad Abozeid
Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder of the gastrointestinal tract (GIT).It results in progressive intestinal epithelium structural and functional damage that necessitates lifetime medication.Thereis imbalance in the production of T helper 1 (Th1), Th2 and Th17 cytokines. This plays a crucial role in the chronic inflammatory process and the defective immune
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Inflammatory bowel disease patients’ perspectives of non-medical needs BMC Gastroenterol. (IF 2.4) Pub Date : 2024-04-13 Narges Norouzkhani, Mahbobeh Faramarzi, Ali Bahari, Javad Shokri Shirvani, Saeid Eslami, Hamed Tabesh
Inflammatory bowel disease (IBD) imposes a huge burden on the healthcare systems and greatly declines the patient’s quality of life. However, there is a paucity of detailed data regarding information and supportive needs as well as sources and methods of obtaining information to control different aspects of the disease from the perspectives of the patients themselves. This study aimed to establish
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Successful therapy with tenofovir disoproxil fumarate (TDF) in patients with chronic hepatitis B (CHB) does not guarantee amelioration of liver damage assessing by transient elastography. A retrospective - prospective multicenter study BMC Gastroenterol. (IF 2.4) Pub Date : 2024-04-12 Hariklia Kranidioti, Konstantinos Zisimopoulos, Theodora Oikonomou, Theodoros Voulgaris, Spyros Siakavellas, Polixeni Agorastou, Melanie Deutsch, Christos Triantos, Ioannis Goulis, George Papatheodoridis, Spilios Manolakopoulos
Preventing disease progression and viral suppression are the main goals of antiviral therapy in chronic hepatitis B (CHB). Liver stiffness measurement (LSM) by transient elastography is a reliable non-invasive method to assess liver fibrosis in patients with CHB. Our aim was to explore factors that may affect changes in LSMs during long term tenofovir (TDF) monotherapy in a well characterized cohort
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Prospective, randomized study comparing two different regimens of split-dose polyethylene glycol and their effect on endoscopic outcomes BMC Gastroenterol. (IF 2.4) Pub Date : 2024-04-12 Jawad Abou Zeid, Souheil Hallit, Bassem Akiki, Zeina Abou Zeid, Charbel Yazbeck
Different split regimens of polyethylene glycol are routinely used and no guidelines are available to select an optimal protocol of ingestion. This study aims to compare the efficacy and side effect profile of two different regimens of polyethylene glycol bowel preparation solution: PEG (3 + 1) vs. PEG (2 + 2). 240 patients above the age of 18 years were included in the study between June 1st and November
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Comparison of vonoprazan dual therapy, quadruple therapy and standard quadruple therapy for Helicobacter pylori infection in Hainan: a single-center, open-label, non-inferiority, randomized controlled trial BMC Gastroenterol. (IF 2.4) Pub Date : 2024-04-12 Chen Chen, Daya Zhang, Shimei Huang, Fan Zeng, Da Li, Xiaodong Zhang, Runxiang Chen, Shiju Chen, Jun Wang, Feihu Bai
To compare the potential efficacy and safety of dual therapy and quadruple therapy with vonoprazan (VPZ) as well as the standard quadruple therapy of proton pump inhibitor (PPI) for the eradication of Helicobacter pylori (Hp) infection in Hainan province. A single-centre, non-blinded, non-inferiority randomized controlled trial was conducted at the outpatient department of gastroenterology at the Second
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Correction: The association between hemoglobin level and sarcopenia in Chinese patients with Crohn’s disease BMC Gastroenterol. (IF 2.4) Pub Date : 2024-04-09 Nandong Hu, Jingjing Liu, Xifa Gao, Hongye Tang, Jiangchuan Wang, Zicheng Wei, Zhongqiu Wang, Xiaoli Yu, Xiao Chen
Correction: BMC Gastroenterol 24, 95 (2024). https://doi.org/10.1186/s12876-024-03182-2 Following publication of the original article it was reported that Table 3 was missing from the PDF version of the published article due to a typesetting mistake whereby Table 4 overlaid it. The HTML version of the article did correctly display Table 3. The original article has been updated to correct the PDF version
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Evaluation of models to predict prognosis in patients with advanced hepatocellular carcinoma treated with TACE combined with apatinib BMC Gastroenterol. (IF 2.4) Pub Date : 2024-04-08 Fang Sun, Kai-Cai Liu, Qurat Ul Ain, Dong Lu, Chun-Ze Zhou, Jing-Kun Xiao, Xing-Ming Zhang, Zheng-Feng Zhang, Deng-Lei Cheng, Yu-Sheng He, Wei-Fu Lv
The HAP, Six-and-Twelve, Up to Seven, and ALBI scores have been substantiated as reliable prognostic markers in patients presenting with intermediate and advanced hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE) treatment. Given this premise, our research aims to assess the predictive efficacy of these models in patients with intermediate and advanced HCC receiving a
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Dietary inflammatory index in relation to the progression of hepatic steatosis and liver fibrosis: evaluation by elastography/Fibroscan BMC Gastroenterol. (IF 2.4) Pub Date : 2024-04-08 Mahsa Miryan, Sameeah Abdulrahman Rashid, Jamshid Gholizadeh Navashenaq, Davood Soleimani, Mohsen Nematy, Jalal Moludi
One of the proposed mechanisms by which nutrition influences the progression of hepatic steatosis to fibrosis is inflammation. The study investigated how the inflammatory potential of the diet affects the risk of liver damage in patients with nonalcoholic fatty liver disease (NAFLD), a condition where fat accumulates in the liver. This cross-sectional study included 170 outpatients with newly diagnosed
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London Protocol under water-perfused HRM in a healthy population, towards novel 3D manometric parameters in an evaluation of anorectal functional disorders BMC Gastroenterol. (IF 2.4) Pub Date : 2024-04-04 Alexandre Anefalos, Carlos Augusto Real Martinez, Claudio Saddy Rodrigues Coy
London Protocol (LP) and Classification allied to high-resolution manometry (HRM) technological evolution has updated and enhanced the diagnostic armamentarium in anorectal disorders. This study aims to evaluate LP reproducibility under water-perfused HRM, provide normal data and new parameters based on 3D and healthy comparison studies under perfusional HRM. Fifty healthy (25 F) underwent water-perfused
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Influential factors on disease activity in Crohn’s disease and their Roc curve evaluation: a cross-sectional study BMC Gastroenterol. (IF 2.4) Pub Date : 2024-04-03 Jing Wang, Shuping Tong, Bingqing Lu
This study aims to investigate the factors influencing disease activity in patients with Crohn’s disease (CD) and provide insights and references for the management and prevention of CD. We recruited CD patients who met the inclusion and exclusion criteria and were treated at the First Affiliated Hospital of Soochow University from November 2022 to June 2023. Generalized linear mixed models were used
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Impact of severe postoperative complications on the prognosis of older patients with colorectal cancer: a two-center retrospective study BMC Gastroenterol. (IF 2.4) Pub Date : 2024-04-02 Daiki Matsubara, Koji Soga, Jun Ikeda, Tatsuya Kumano, Masato Mitsuda, Tomoki Konishi, Shuhei Komatsu, Katsumi Shimomura, Fumihiro Taniguchi, Yasuhiro Shioaki, Eigo Otsuji
The occurrence of postoperative complications may affect short-term outcomes and prognosis of patients with various malignancies. However, the prognostic impact of these complications in older patients with colorectal cancer (CRC) remains unclear. Therefore, this study aimed to investigate the impact of severe postoperative complications on the oncological outcomes of older (aged ≥ 80 years) and non-older
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Safety and efficacy of a low-dose combination of midazolam, alfentanil, and propofol for deep sedation of elderly patients undergoing ERCP BMC Gastroenterol. (IF 2.4) Pub Date : 2024-04-02 Yanping Zhang, Ning Zhang, Jing Hu, Changlin Liu, Guanjun Li
Proper sedation of patients, particularly elderly individuals, who are more susceptible to sedation-related complications, is of significant importance in endoscopic retrograde cholangiopancreatography (ERCP). This study aims to assess the safety and efficacy of a low-dose combination of midazolam, alfentanil, and propofol for deep sedation in elderly patients undergoing ERCP, compared to a group of
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Management of hepatocellular carcinoma, an important cause of death in Japanese autoimmune hepatitis patients BMC Gastroenterol. (IF 2.4) Pub Date : 2024-04-01 Tomoko Tadokoro, Takako Nomura, Koji Fujita, Takushi Manabe, Kei Takuma, Mai Nakahara, Kyoko Oura, Shima Mimura, Joji Tani, Asahiro Morishita, Hideki Kobara, Masafumi Ono, Tsutomu Masaki
Hepatocellular carcinoma (HCC) in autoimmune hepatitis (AIH) was considered rare but is increasing with prolonged prognosis. Its impact on the overall prognosis of AIH is unknown, and treatment has not been established. To investigate the risk factors and prognosis of HCC in patients with AIH and identify appropriate management strategies. We studied patients with AIH including background liver disease
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Endoscopic diagnosis of gastric and oesophageal cancer in Lusaka, Zambia: a retrospective analysis BMC Gastroenterol. (IF 2.4) Pub Date : 2024-04-01 Violet Kayamba, Malambo Mubbunu, Paul Kelly
There are uncertainties surrounding the spectrum of upper gastrointestinal (UGI) diseases in sub-Saharan Africa. This is mainly due to the limitations of data collection and recording. We previously reported an audit of UGI endoscopic diagnoses in Zambia spanning from 1977 to 2014. We now have extended this analysis to include subsequent years, in order to provide a more comprehensive picture of how
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Comparative efficacy and safety of subcutaneous infliximab and vedolizumab in patients with Crohn’s disease and ulcerative colitis included in randomised controlled trials BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-27 Laurent Peyrin‐Biroulet, Perttu Arkkila, Alessandro Armuzzi, Silvio Danese, Marc Ferrante, Jordi Guardiola, Jørgen Jahnsen, Edouard Louis, Milan Lukáš, Walter Reinisch, Xavier Roblin, Philip J Smith, Taek Kwon, Jeeyoung Kim, Sangwook Yoon, Dong-Hyeon Kim, Raja Atreya
While indirect comparison of infliximab (IFX) and vedolizumab (VDZ) in adults with Crohn’s disease (CD) or ulcerative colitis (UC) shows that IFX has better effectiveness during induction, and comparable efficacy during maintenance treatment, comparative data specific to subcutaneous (SC) IFX (i.e., CT-P13 SC) versus VDZ are limited. Pooled analysis of randomised studies to compare efficacy and safety
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Patients with chronic hepatitis B who have persistently normal alanine aminotransferase or aged < 30 years may exhibit significant histologic damage BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-27 Sufang Wei, Qiuli Xie, Guichan Liao, Hongjie Chen, Meixin Hu, Xiaoli Lin, Hong Li, Jie Peng
The timing of antiviral therapy for chronic hepatitis B (CHB) patients with normal alanine transaminase (ALT) or aged < 30 years is still undetermined. We aimed to elucidate the correlation between liver histology, age, and ALT level in CHB patients and analyze the histological characteristics of the liver among patients with persistently normal ALT or aged < 30 years. A retrospective analysis was
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Evaluating the efficacy of different volume resuscitation strategies in acute pancreatitis patients: a systematic review and meta-analysis BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-25 Roopa Kumari, FNU Sadarat, Sindhu Luhana, Om Parkash, Abhi Chand Lohana, Zubair Rahaman, Hong Yu Wang, Yaqub N Mohammed, Sanjay Kirshan Kumar, Subhash Chander
Acute pancreatitis poses a significant health risk due to the potential for pancreatic necrosis and multi-organ failure. Fluid resuscitation has demonstrated positive effects; however, consensus on the ideal intravenous fluid type and infusion rate for optimal patient outcomes remains elusive. A comprehensive literature search was conducted using PubMed, Embase, the Cochrane Library, Scopus, and Google
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Perioperative outcomes of the surgical management of achalasia in two tertiary Cameroonian hospitals: a cohort study BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-22 Joël Igor Kamla, Guy Aristide Bang, Joel Noutakdie Tochie, George Motto Bwelle, Blondel Nana Oumarou, Bernadette Ngo Nonga
Achalasia is a rare esophageal disease with potentially lethal complications. Knowledge of the outcomes of the different surgical treatment modalities for achalasia by Heller’s cardiomyotomy (HCM) helps to choose the safest and most effective option. However, data on the management of achalsia using a Heller myotomy is limited in Africa. Thus, our aim was to determine the perioperative morbidity, mortality
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Optimizing LI-RADS: ancillary features screened from LR-3/4 categories can improve the diagnosis of HCC on MRI BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-21 Zi-xin Zhang, Hui Xv, Yan-ni Du, Zhi-bin Lv, Zheng-han Yang
To determine the high-efficiency ancillary features (AFs) screened from LR-3/4 lesions and the HCC/non-HCC group and the diagnostic performance of LR3/4 observations. We retrospectively analyzed a total of 460 patients (with 473 nodules) classified into LR-3-LR-5 categories, including 311 cases of hepatocellular carcinoma (HCC), 6 cases of non-HCC malignant tumors, and 156 cases of benign lesions.
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Characterization of primary small intestinal lymphoma: a retrospective study based on double balloon endoscopy BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-20 Lin Li, Huijian Ma, Meng Niu, Chunxiao Chen, Chaohui Yu, Hong Zhang, Meng Jin
The diagnosis of primary small intestinal lymphoma (PSIL) is difficult. This study aimed to evaluate the clinical, radiological and endoscopic characteristics of PSIL and provide clue for diagnosis. A total of 30 patients diagnosed with PSIL who underwent double balloon endoscopy (DBE) in the First Affiliated Hospital of Zhejiang University were retrospectively analyzed. Clinical, radiological and
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Correction: The association between hemoglobin level and sarcopenia in Chinese patients with Crohn’s disease BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-19 Nandong Hu, Jingjing Liu, Xifa Gao, Hongye Tang, Jiangchuan Wang, Zicheng Wei, Zhongqiu Wang, Xiaoli Yu, Xiao Chen
Correction:BMC Gastroenterol24, 95 (2024) https://doi.org/10.1186/s12876-024-03182-2 Following publication of the original article it was reported that Xiaoli Yu was missing a designation as corresponding author. The original article has been updated to correctly identify Xiaoli Yu as a corresponding author.Author notes Nandong Hu and Jingjing Liu contributed equally to this work. Authors and Affiliations
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Feasibility and repeatability of ultrasound-guided surface electroenterography to measure colonic slow wave motility in healthy adults BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-18 Nick H. Rolleman, Iris M. Visser, Willemijn M. Klein, Michel J.A.M. Van Putten, Ivo De Blaauw, Sanne M.B.I. Botden
Surface electroenterography is a potential non-invasive alternative to current diagnostics of colonic motility disorders. However, electrode positioning in electroenterography is often based on general anatomy and may lack generalizability. Furthermore, the repeatability of electroenterography measurements is unknown. This study aimed to evaluate ultrasound-guided electrode positioning for electroenterography
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Association of lymphocyte subsets with the efficacy and prognosis of PD‑1 inhibitor therapy in advanced gastric cancer: results from a monocentric retrospective study BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-15 Xinyan Wang, Xiaoling Liu, Huwei Dai, Junmei Jia
This retrospective study aimed to investigate the changes in peripheral blood lymphocyte subsets before and after immunotherapy in patients with advanced gastric cancer and their relationship n with the therapeutic efficacy and clinical prognosis. Peripheral blood lymphocyte subsets, including CD4 + T cells, CD8 + T cells, CD4+/CD8 + ratio, NK cells, Treg cells, and B cells, were collected from 195
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Poly-ϵ-caprolactone scaffold as staple-line reinforcement of rectal anastomosis: an experimental piglet study BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-15 Laura Lovisa Køtlum Petersen, Martin Dennis Dursun, Gunvor Madsen, Dang Quang Svend Le, Sören Möller, Niels Qvist, Mark Bremholm Ellebæk
Rectal anastomoses have a persisting high incidence of anastomotic leakage. This study aimed to assess whether the use of a poly-ϵ-caprolactone (PCL) scaffold as reinforcement of a circular stapled rectal anastomosis could increase tensile strength and improve healing compared to a control in a piglet model. Twenty weaned female piglets received a stapled rectal anastomosis and were randomised to either
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The relationship between sarcopenia and metabolic dysfunction-associated fatty liver disease among the young and middle-aged populations BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-15 Ziyan Feng, Fanrong Zhao, Ziyao Wang, Xinyi Tang, Yan Xie, Li Qiu
Metabolic dysfunction-associated fatty liver disease (MAFLD) has been proposed as a new term for diagnosing fatty liver disease, which is considered to be a multi-systemic disease with multiple extrahepatic manifestations, including sarcopenia. The link between sarcopenia and MAFLD remains uncertain, especially among young and middle-aged adults. Thus, we examined the relationship between MAFLD and
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Comparison of vonoprazan and proton pump inhibitors for the treatment of gastric endoscopic submucosal dissection-induced ulcer: an updated systematic review and meta-analysis BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-15 Lizhen Chen, Dalei Jiang, Doudou Hu, Xianghua Cui
Both vonoprazan and proton pump inhibitors (PPIs) are currently used to treat artificial ulcers after gastric endoscopic submucosal dissection. However, evidence-based medicine proving the efficacy of vonoprazan is still lacking. Therefore, this meta-analysis aimed to compare the efficacy of vonoprazan and PPIs for the treatment of artificial ulcers after gastric endoscopic submucosal dissection. The
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Using new indices to predict metabolism dysfunction-associated fatty liver disease (MAFLD): analysis of the national health and nutrition examination survey database BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-15 Xu Ming Li, Song Lian Liu, Ya Jun He, Jian Chang Shu
Metabolism dysfunction-associated fatty liver disease (MAFLD), is the most common chronic liver disease. Few MAFLD predictions are simple and accurate. We examined the predictive performance of the albumin-to-glutamyl transpeptidase ratio (AGTR), plasma atherogenicity index (AIP), and serum uric acid to high-density lipoprotein cholesterol ratio (UHR) for MAFLD to design practical, inexpensive, and
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Prognostic factors of pancreatic tumors in children and adolescents: a population study based on the surveillance, epidemiology, and end results database BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-14 Xianzhong Qi, Bi Zhou, Fuhua Liang, Xinxin Wang
Pancreatic tumors in children are uncommon, and data is scarce. The purpose of this study is to examine the prognostic factors of pediatric pancreatic tumors in a population-based cohort. The Surveillance, Epidemiology, and End Results (SEER) database was used to identify all pediatric patients with pancreatic tumors diagnosed between 1975 and 2018. The overall survival (OS) rates were determined using
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Circulatory resistin levels in inflammatory bowel disease: a systematic review and meta-analysis BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-14 Amir Hossein Behnoush, Seyede Parmis Maroufi, Tara Reshadmanesh, Yasmin Mohtasham Kia, Mitra Norouzi, Seyedeh Mina Mohammadi, Aleksandra Klisic, Amirmohammad Khalaji
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic relapsing-remitting systemic disease of the gastrointestinal tract with rising incidence. Studies have shown that adipocytes play a crucial role in patients with IBD by actively participating in systemic immune responses. The present study was designed to investigate the correlation between the
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Effect and potential mechanism of oncometabolite succinate promotes distant metastasis of colorectal cancer by activating STAT3 BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-14 Jiangnan Yu, Hong Yang, Lin Zhang, Suye Ran, Qing Shi, Pailan Peng, Qi Liu, Lingyu Song
To investigate the effect of Oncometabolite succinate on colorectal cancer migration and invasion and to initially explore the underlying mechanism.Succinate acid detection kit detected the succinate content in tissues. The growth of colorectal cancer cells was measured by cck-8 assay, wound-healing migration assay and transwell migration and invasion assays, and then explored the level of epithelial-mesenchymal
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Symptoms, burden, and unmet needs of patients living with exocrine pancreatic insufficiency: a narrative review of the patient experience BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-14 Jodie A. Barkin, Trudi B. Delk, Valerie J. Powell
Exocrine pancreatic insufficiency (EPI) stems from a deficiency of functional pancreatic enzymes with consequent maldigestion and malnutrition. EPI shares clinical symptoms and manifestations with other disorders and is a considerable burden to individuals affected. In this narrative review, we analyzed the literature to identify relevant publications on living with EPI with the scope of individuating
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Clinical features of inflammatory bowel disease unclassified: a case-control study BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-13 Yupei Shao, Yixiao Zhao, Hong Lv, Pengguang Yan, Hong Yang, Jingnan Li, Ji Li, Jiaming Qian
Approximately 10-15% of inflammatory bowel disease (IBD) patients with overlapping features of ulcerative colitis (UC) and Crohn’s disease (CD) are termed as inflammatory bowel disease unclassified (IBDU). This study aimed to describe the clinical features of IBDU and evaluate the potential associated factors of reclassification. The clinical data of 37 IBDU patients were retrospectively analyzed from
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Construction and validation of a nomogram for cancer specific survival of postoperative pancreatic cancer based on the SEER and China database BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-13 Wei Peng, Xiaopeng Yu, Renyi Yang, Sha Nie, Xiaolan Jian, Puhua Zeng
The recurrence rate and mortality rate among postoperative pancreatic cancer patients remain elevated. This study aims to develop and validate the cancer-specific survival period for individuals who have undergone pancreatic cancer surgery. We extracted eligible data from the Surveillance, Epidemiology, and End Results database and randomly divided all patients into a training cohort and an internal
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Hemorrhoidal disease among doctors from grade-A tertiary hospitals in big cities of China: results from web-based doctors as patients survey BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-13 Xiaoyuan Qiu, Yuxin Liu, Weikun Shi, Guole Lin, Mei Rong, Bingjie Wang
Doctors are at high risk of developing hemorrhoidal disease (HD), but it is unclear whether doctors are aware of this risk. The OASIS (dOctors AS patIentS) study was performed to examine the prevalence, awareness, diagnosis, and treatment of HD among doctors in big cities in China. An online survey consisting of a structured questionnaire was carried out among doctors in grade-A tertiary hospitals
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Gender differences in gastrointestinal, biopsychosocial and healthcare-seeking behaviors in Chinese patients with irritable bowel syndrome predominant with diarrhea BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-13 Wenjuan Fan, Yang Chen, Xiucai Fang, Liming Zhu, Guijun Fei, Jia Lu, Xiaoqing Li
Evidences of comparison of sex difference in Chinese irritable bowel syndrome (IBS) patients were few. We aim to compare gender difference in the biopsychosocial characteristics of Chinese patients of IBS predominant with diarrhea (IBS-D). IBS-D patients meeting Rome III criteria were enrolled. We administered IBS symptom questionnaires, evaluation of psychological status (HAMD and HAMA scales) and
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Investigating the mortality trend of gastrointestinal cancers in Babol, North Iran (2013–2021) BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-06 Pouyan Ebrahimi, Mohsen Karami, Sahar Delavari, Layla Shojaie, Seyed-Hossein Hosseini-Berneti, Fatemeh Bayani, Mehdi Moghaddasi, Ozra Babazade, Hossein-Ali Nikbakht
This study aims to examine the mortality rate and trend of gastrointestinal cancers, particularly gastric cancer, as the leading cause of death among cancers in northern Iran over a 9-year period. In light of the changing incidence and mortality rates of cancer in Iran and around the world, the importance of these diseases in people’s lives, and the necessity of updating and monitoring the trend of
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A colonial serrated polyp classification model using white-light ordinary endoscopy images with an artificial intelligence model and TensorFlow chart BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-05 Tsung-Hsing Chen, Yu-Tzu Wang, Chi-Huan Wu, Chang-Fu Kuo, Hao-Tsai Cheng, Shu-Wei Huang, Chieh Lee
In this study, we implemented a combination of data augmentation and artificial intelligence (AI) model—Convolutional Neural Network (CNN)—to help physicians classify colonic polyps into traditional adenoma (TA), sessile serrated adenoma (SSA), and hyperplastic polyp (HP). We collected ordinary endoscopy images under both white and NBI lights. Under white light, we collected 257 images of HP, 423 images
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Comparison of prognostic outcomes between endoscopic submucosal dissection and surgical treatment for early gastric cancer: a retrospective cohort study BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-04 Yifan Zhang, Fangzhen Shi, Yuxiang Fan, Gang Liu, Chengkai Xia, Haodong Wang
The optimal management strategy for early gastric cancer (EGC) a topic of contention. This study aims to compare the prognostic outcomes of endoscopic submucosal dissection (ESD) and surgical treatment in patients diagnosed with EGC. In thisretrospective cohort study, we analyzed data from539 patients diagnosed with EGC between January 2012 and December 2020 from two centers. We compared Clinicopathological
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Nuclear respiratory factor 1 regulates super enhancer-controlled SPIDR to protect hepatocellular carcinoma cells from oxidative stress BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-04 Baowang Liu, Jian Dou, Jinglin Cao
Cellular response to oxidative stress plays significant roles in hepatocellular carcinoma (HCC) development, yet the exact mechanism by which HCC cells respond to oxidative stress remains poorly understood. This study aimed to investigate the role and mechanism of super enhancer (SE)-controlled genes in oxidative stress response of HCC cells. The GSE112221 dataset was used to identify SEs by HOMER
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Non-alcoholic fatty liver disease in Tanzania: prevalence, determinants, and diagnostic performance of triglycerides-glucose index and triglycerides-glucose index –body mass index compared to the hepatic ultrasound in overweight and obese individuals BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-04 Semvua B. Kilonzo, Eliud Kamala, Hyasinta Jaka, Patrick Ngoya
Non-alcoholic fatty liver disease (NAFLD), which is closely associated with metabolic syndrome (MetS), is rarely reported in Tanzania, where MetS is prevalent. The purpose of this study was to determine the prevalence and associated factors of this condition in overweight and obese individuals and to correlate standard ultrasound diagnosis with triglyceride-glucose index (TyG) and TyG-body mass index
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The association between hemoglobin level and sarcopenia in Chinese patients with Crohn’s disease BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-04 Nandong Hu, Jingjing Liu, Xifa Gao, Hongye Tang, Jiangchuan Wang, Zicheng Wei, Zhongqiu Wang, Xiaoli Yu, Xiao Chen
Sarcopenia and anemia are common complications in patients with Crohn’s Disease (CD). However, few studies have shown the association between sarcopenia and hemoglobin levels in CD patients. This retrospective study aimed to explore such association in Chinese patients with CD. Two hundred and twelve adult CD inpatients who underwent computed tomography (CT) or magnetic resonance imaging (MRI) examinations
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Preventive and therapeutic effects of rifaximin on hepatic encephalopathy with differential application dosages and strategies: a network meta-analysis BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-04 Guihua Fang, Shuna Liu, Bin Liu
Hepatic encephalopathy (HE) is a neuropsychiatric syndrome that affects the prognosis of patients with liver disease and is considered an independent risk factor for hospitalization and death. Rifaximin has been approved for HE treatment. This review will analyze the effect of rifaximin on different stages of HE with differential application dosages and strategies by traditional and network meta-analyses
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Prediction of survival and analysis of prognostic factors for patients with AFP negative hepatocellular carcinoma: a population-based study BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-04 Chengyu Liu, Zikang Li, Zhilei Zhang, Jinlong Li, Congxi Xu, Yuming Jia, Chong Zhang, Wuhan Yang, Wenchuan Wang, Xiaojuan Wang, Kuopeng Liang, Li Peng, Jitao Wang
Hepatocellular carcinoma (HCC) has a poor prognosis, and alpha-fetoprotein (AFP) is widely used to evaluate HCC. However, the proportion of AFP-negative individuals cannot be disregarded. This study aimed to establish a nomogram of risk factors affecting the prognosis of patients with AFP-negative HCC and to evaluate its diagnostic efficiency. Data from patients with AFP-negative initial diagnosis
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Efficacy of transcatheter arterial embolization in treating nonvariceal gastric remnant bleeding: a retrospective 5-year study BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-04 Weida Wu, Jianyang Peng, Guohui Zhou, Chunsheng Zhang, Yuanzhen Lin, Zhicheng Weng
Gastric remnant bleeding is a special case of upper gastrointestinal bleeding with certain specific disease characteristics, and some matters of transcatheter arterial embolization (TAE) for hemostasis need attention. In this study, we aimed to explore the clinical use of TAE in patients with nonvariceal gastric remnant bleeding and identify the factors influencing the clinical efficacy of these interventions
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Downregulation of SMOC1 is associated with progression of colorectal traditional serrated adenomas BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-01 Hironori Aoki, Akira Takasawa, Eiichiro Yamamoto, Takeshi Niinuma, Hiro-o Yamano, Taku Harada, Toshiyuki Kubo, Akira Yorozu, Hiroshi Kitajima, Kazuya Ishiguro, Masahiro Kai, Akio Katanuma, Toshiya Shinohara, Hiroshi Nakase, Tamotsu Sugai, Makoto Osanai, Hiromu Suzuki
Aberrant DNA methylation is prevalent in colorectal serrated lesions. We previously reported that the CpG island of SMOC1 is frequently methylated in traditional serrated adenomas (TSAs) and colorectal cancers (CRCs) but is rarely methylated in sessile serrated lesions (SSLs). In the present study, we aimed to further characterize the expression of SMOC1 in early colorectal lesions. SMOC1 expression
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Scoping review of values elicitation tools for treatment decisions in hepatocellular carcinoma BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-28 Gabrielle Ritaccio, A. Sidney Barritt IV, Jamie L. Conklin, Daniel R. Richardson, Donna M. Evon, Hanna K. Sanoff, Ethan Basch, Stephanie B. Wheeler, Andrew M. Moon
Treatment choices in hepatocellular carcinoma (HCC) involve consideration of tradeoffs between the benefits, toxicities, inconvenience, and costs. Stated preference elicitation methods have been used in the medical field to help evaluate complex treatment decision-making. The aim of this study was to conduct a scoping review to assess the evidence base for the use of preference elicitation tools or
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Development and validation of comprehensive nomograms from the SEER database for predicting early mortality in metastatic rectal cancer patients BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-26 Yanli Li, Ting Tao, Yun Liu
Metastatic rectal cancer is an incurable malignancy, which is prone to early mortality. We aimed to establish nomograms for predicting the risk of early mortality in patients with metastatic rectal cancer. In this study, clinical data were obtained from the Surveillance, Epidemiology, and End Results (SEER) database.We utilized X-tile software to determine the optimal cut-off points of age and tumor
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The frequency of colorectal lesions in the first-degree relatives of patients with colorectal lesions among PERSIAN Guilan Cohort Study population (PGCS) BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-26 Somaieh Matin, Farahnaz Joukar, Saman Maroufizadeh, Mehrnaz Asgharnezhad, Paridokht Karimian, Fariborz Mansour-Ghanaei
This study aimed to investigate the frequency of colorectal lesions in the first-degree relatives of patients with colorectal lesions among the Prospective Epidemiological Research Studies in Iran (PERSIAN )Guilan Cohort Study (PGCS) population. In this cross-sectional study, 162 first-degree relatives with a history of colorectal lesions were randomly selected from 52 participants in PGCS. All subjects
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The effects of low-dose IL-2 on Th17/Treg cell imbalance in primary biliary cholangitis mouse models BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-26 Zilong Wang, Zhicheng Liu, Jiarui Zheng, Linxiang Huang, Rui Jin, Xiaoxiao Wang, Dongbo Chen, Yandi Xie, Bo Feng
Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease. The imbalance of Th17/Treg cells has been reported in PBC patients. Low-dose IL-2 can alleviate disease severity through modulating CD4 + T cell subsets in patients with autoimmune diseases. Hence, the present study aimed to examine the effects and mechanism of low-dose IL-2 in PBC mouse models. PBC models were induced in female
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Correction: The important role of whole-process computed tomography guidance for percutaneous gastrostomy in esophageal cancer patients who are unsuitable for or have had unsuccessful attempts with endoscopic and fuoroscopic gastrostomy BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-26 Xiang Geng, Qing Zhao, Hang Yuan, Hai-Liang Li, Chen-Yang Guo, Ting Yang, Wei-Jun Fan, Jung-Hoon Park, Xiao-Hui Zhao, Wen-Bo Zhu, Hong-Tao Hu
Correction: BMC Gastroenterol (2024) 24:14 https://doi.org/10.1186/s12876-023-03040-7 Following publication of the original article it was reported that there was an error in affiliation 1, namely that ‘Henan Cancer Hospital’ preceded ‘The Affiliated Cancer Hospital of Zhenzhou Univeristy’. The original article has been updated.Author notes Xiang Geng and Qing Zhao contributed equally to this work
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The impact of Karnofsky performance status on prognosis of patients with hepatocellular carcinoma in liver transplantation BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-26 Jie Zhou, Danni Ye, Siyao Zhang, Jiawei Ding, Tao Zhang, Zheng Chen, Fangshen Xu, Shenli Ren, Zhenhua Hu
Functional performance as measured by the Karnofsky Performance Status (KPS) scale has been linked to the outcomes of liver transplant patients; however, the effect of KPS on the outcomes of the hepatocellular carcinoma (HCC) liver transplant population has not been fully elucidated. We aimed to investigate the association between pre-transplant KPS score and long-term outcomes in HCC patients listed
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miR-541 is associated with the prognosis of liver cirrhosis and directly targets JAG2 to inhibit the activation of hepatic stellate cells BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-23 Jin-Pei Liu, Shao-Hua Song, Pei-Mei Shi, Xiao-Yu Qin, Bai-Nan Zheng, Shu-Qing Liu, Chen-Hong Ding, Xin Zhang, Wei-Fen Xie, Yi-Hai Shi, Wen-Ping Xu
The activation of hepatic stellate cells (HSCs) has been emphasized as a leading event of the pathogenesis of liver cirrhosis, while the exact mechanism of its activation is largely unknown. Furthermore, the novel non-invasive predictors of prognosis in cirrhotic patients warrant more exploration. miR-541 has been identified as a tumor suppressor in hepatocellular carcinoma and a regulator of fibrotic
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Correlation between white blood cell count and intestinal resection in patients with acute mesenteric vein thrombosis BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-23 Yu Xu, Shang-Tai Dai, Hong-Qiao Lu, Wei Chen, Zhi-Wei Xiong, Jiang Liu, Yong-Jiang Tang, Shi-Kui Guo, Kun-Mei Gong
Acute mesenteric vein thrombosis (AMVT) is an acute abdominal disease with onset, rapid progression, and extensive intestinal necrosis that requires immediate surgical resection. The purpose of this study was to determine the risk factors for nosocomial intestinal resection in patients with AMVT. We retrospectively analysed 64 patients with AMVT diagnosed by CTA at the Affiliated Hospital of Kunming
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Association between colorectal cancer, the frequency of Bacteroides fragilis, and the level of mismatch repair genes expression in the biopsy samples of Iranian patients BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-23 Nooshin Nazarinejad, Bahareh Hajikhani, Amir Abbas Vaezi, Farzaneh Firoozeh, Fatemeh Sameni, Somayeh Yaslianifard, Mehdi Goudarzi, Masoud Dadashi
Deficient DNA mismatch repair (MMR) can cause microsatellite instability (MSI) and is more common in colorectal cancer (CRC) patients. Understanding the carcinogenic mechanism of bacteria and their impact on cancer cells is crucial. Bacteroides fragilis (B. fragilis) has been identified as a potential promoter of tumorigenesis through the alteration of signaling pathways. This study aims to assess
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Comparative study of ultrasound attenuation analysis and controlled attenuation parameter in the diagnosis and grading of liver steatosis in non-alcoholic fatty liver disease patients BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-23 Mengyun Wang, Shuzhen Tang, Guoqiu Li, Zhibin Huang, Sijie Mo, Keen Yang, Jing Chen, Baishan Du, Jinfeng Xu, Zhimin Ding, Fajin Dong
To assess the diagnostic performance of Ultrasound Attenuation Analysis (USAT) in the diagnosis and grading of hepatic steatosis in patients with non-alcoholic fatty liver disease (NAFLD) using Controlled Attenuation Parameters (CAP) as a reference. From February 13, 2023, to September 26, 2023, participants underwent CAP and USAT examinations on the same day. We used manufacturer-recommended CAP thresholds
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Reading of small bowel capsule endoscopy after frame reduction using an artificial intelligence algorithm BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-22 Dong Jun Oh, Youngbae Hwang, Sang Hoon Kim, Ji Hyung Nam, Min Kyu Jung, Yun Jeong Lim
Poorly visualized images that appear during small bowel capsule endoscopy (SBCE) can confuse the interpretation of small bowel lesions and increase the physician’s workload. Using a validated artificial intelligence (AI) algorithm that can evaluate the mucosal visualization, we aimed to assess whether SBCE reading after the removal of poorly visualized images could affect the diagnosis of SBCE. A study
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Impact of insomnia upon inflammatory digestive diseases and biomarkers: a two-sample mendelian randomization research on Europeans BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-21 Lei Dai, Yunyan Ye, Joseph Mugaanyi, Caide Lu, Changjiang Lu
A number of observational studies indicate that insomnia is linked to inflammatory digestive diseases (IDDs). However, the definite relationship between insomnia and IDDs remains unclear. We obtained the publicly available data from genome-wide association studies (GWAS) to conduct two-sample Mendelian randomization (MR) for association assessment. Five MR analysis methods were used to calculate the
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A comprehensive study on non-cancer-related mortality risk factors in elderly gastric cancer patients post-curative surgery BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-19 Yuki Ushimaru, Shinnosuke Nagano, Kazuhiro Nishikawa, Ryohei Kawabata, Tomohira Takeoka, Akihiro Kitagawa, Nobuyoshi Ohara, Hideo Tomihara, Sakae Maeda, Mitsunobu Imazato, Shingo Noura, Atsushi Miyamoto
The increasing incidence of gastric cancer in the elderly underscores the need for an in-depth understanding of the challenges and risks associated with surgical interventions in this demographic. This study aims to investigate the risk factors and prognostic indicators for non-cancer-related mortality following curative surgery in elderly gastric cancer patients. This retrospective analysis examined