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Effect of Tofacitinib on One-Year Colectomy Risk in Anti-TNF Refractory Ulcerative Colitis: A Prospective Multicenter Italian Study Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-26
Abstract Background Tofacitinib is an oral Janus kinase inhibitor recently approved to induce and maintain remission in ulcerative colitis (UC). Aims Considering the number of anti-TNF non-responders, this study aims to assess the effectiveness and safety of tofacitinib in a cohort of multi-failure patients with moderate-to-severe UC at 52 weeks. Methods From January 2021 to March 2023, we performed
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Saliva Production and Esophageal Motility Influence Esophageal Acid Clearance Related to Post-reflux Swallow-Induced Peristaltic Wave Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-25
Abstract Background The post-reflux swallow-induced peristaltic wave (PSPW) brings salivary bicarbonate to neutralize residual distal esophageal mucosal acidification. Aims To determine if reduced saliva production and esophageal body hypomotility would compromise PSPW-induced pH recovery in the distal esophagus. Methods In this multicenter retrospective cross-sectional study, patients with confirmed
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Review of Animal Models of Colorectal Cancer in Different Carcinogenesis Pathways Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-25
Abstract Colorectal cancer (CRC) is a common malignant tumor of the gastrointestinal tract with increasing morbidity and mortality. Exploring the factors affecting colorectal carcinogenesis and controlling its occurrence at its root is as important as studying post-cancer treatment and management. Establishing ideal animal models of CRC is crucial, which can occur through various pathways, such as
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Colonoscopy Utilization in Elderly Patients with Dementia: Characteristics, Complications, and Charges in a National Matched-Cohort Analysis Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-25 Faris Shweikeh, Gordon Hong, Kathleen Rogers, Mohamad Mouchli, Matthew Hoscheit, Anthony Lembo
Background It is projected that the elderly population will continue to increase. Many will develop chronic conditions such as dementia. Aims Our aims are to describe the utilization of colonoscopy among patients with dementia and compare outcomes in those with and without dementia. Methods This population-based analysis utilized the National Inpatient Sample (NIS) during 2019. Patients with dementia
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Early Endoscopic Interventions for Pancreatic Necrosis: Indications, Technique, and Outcomes Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-25
Abstract Endoscopic transmural drainage is usually performed for symptomatic well-encapsulated walled-off necrosis (WON) that usually develops in the delayed phase (> 4 weeks after disease onset) of acute necrotising pancreatitis (ANP). Endoscopic drainage is usually not advocated in the early (< 4 weeks after disease onset) stage of illness because of the risk of complications due to an incompletely
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An Unusual Case of Refractory Esophagitis and Esophageal Diverticulum Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-23 Achintya D. Singh, Michael Kurin
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Antegrade Electrohydraulic Lithotripsy for Common Bile Duct Stone Using Novel Cholangioscope with Large Working Channel Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-23 Takeshi Ogura, Junichi Nakamura, Hiroki Nwashikawa
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Lack of Diversity in Transplant Hepatology Fellowship Program Directorship Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-23 Faraz Jafri, Shahbaz Saad, Hamna Riaz, Farah Saleem, Sara Gottesman
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Real-World Outcomes of Dual Advanced Therapy in Children and Young Adults with Inflammatory Bowel Disease Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-23 Amelia Kellar, Michael T. Dolinger, Elizabeth A. Spencer, Marla C. Dubinsky
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Exogenous Insulin Therapy Is Associated with the Risk of Advanced Colorectal Adenoma in Patients with Diabetes Mellitus Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-22 Robert Lam, Wei-Ting Hwang, Sumanth Chennareddy, Ben Boursi, Yu-Xiao Yang
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Efficacy and Safety of Anhydrous Ethanol-Assisted Endoscopic Ultrasound-Guided Transluminal Necrosectomy in Infected Necrotizing Pancreatitis Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-22 Yan Zeng, Jun-Wen Zhang, Jian Yang
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Primary Sclerosing Cholangitis: Gender Effects in Valencia’s Low-Prevalence Region Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-22 Alejandro Mínguez, Isabel Conde, Cristina Montón, Lara Gonzalez, Sonia Pascual, María Dolores Antón, Antonio Palau, Ana Forés, Concha Gisbert, Asunción Ojeda, Eva Girona, Tommaso Di Maira, Marina Berenguer
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A Novel Nomogram for Predicting Early Rebleeding After Endoscopic Treatment of Esophagogastric Variceal Hemorrhage Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-21 Yongqi Dong, Hongyan Xu, Zhihuan Zhang, Zhihang Zhou, Gang Zhao, Haiyan Cao, Shiyong Xiao
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Precutting Endoscopic Band Ligation-Assisted Resection Is Safe and Effective for Treating Gastric Submucosal Tumors from the Muscularis Propria Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-20
Abstract Background We previously treated small gastric submucosal tumors originating from the muscularis propria layer by precutting endoscopic band ligation but lacked precise pathological results. Then, precutting endoscopic band ligation was modified by additional snare resection after ligation to obtain tumor specimens, termed precutting endoscopic band ligation-assisted resection. Aims In this
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Implementation and Analysis of a 5-Year Online Esophageal Motility Curriculum for Gastroenterology Fellows Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-20 Connie W. Wang, Christopher R. Lees, Myung S. Ko, Justin L. Sewell, Priya Kathpalia
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Highly Expressed Z-DNA Binding Protein 1 in Esophageal Cancer Promotes Tumor Growth Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-20 Shabahaiti Wusiman, Yining Liu, Hui Li, Yuhan Deng, Ximing Qu, Hainisayimu Tuerxun, Ling Liu
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Some Drugs Have Two Faces: Paradoxical Colitis in a Patient with Psoriatic Arthritis Previously Treated with Etanercept and IL-17 Inhibitors Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-19 Sandy Huynh, Sudharshan Achalu, Rani Berry, Janice Lin, Cindy X. Wang, John Gubatan, Alice G. Cheng
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Endoscopic Ultrasound-Guided Pelvic Abscess Drainage: A Successful Minimally Invasive Approach Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-18 Luís Correia Gomes, Pedro Pinto Marques, Filipe Almeida, Carla Oliveira, Francisco Vara Luiz, Marta Patita, Jorge Fonseca
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“It’s Not a Gas”: The Future of Testing for Lactose Intolerance Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-18 Heinz F. Hammer, Johann Hammer
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Added Value of 13C Analysis in Breath Tests in H2-Negative Subjects to Diagnose Lactose Malabsorption: A Proof of Concept Study Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-18 Lukas Michaja Balsiger, Els Houben, Tim Vanuytsel, Marc van Ranst, Jan Tack, Kristin Verbeke
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Comparative Efficacy of Subcutaneous and Intravenous Infliximab and Vedolizumab for Maintenance Treatment of TNF-naive Adult Patients with Inflammatory Bowel Disease: A Systematic Literature Review and Network Meta-analysis Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-18 L. Peyrin-Biroulet, P. Bossuyt, D. Bettenworth, E. V. Loftus, S. I. Anjie, G. D’Haens, M. Saruta, P. Arkkila, H. Park, D. Choi, D- H. Kim, W. Reinisch
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Development of Clinical Algorithm Utilizing Vibration-Controlled Transient Elastography to Detect Advanced Hepatic Fibrosis in Liver Transplant Recipients Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-18 Tamoore Arshad, Dylan Vainer, Hiba Khan, Alok Baral, Shreya Garg, Audrey Ang, Vaishali Patel, Vinay Kumaran, David Bruno, Seung Lee, Amit Sharma, Mark Muthiah, Anh T. Bui, Mohammad Shadab Siddiqui
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Effect of Suboptimal Disease Control on Patient Quality of Life: Real-World Data from the Observational IBD-PODCAST Canada Trial Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-16 Jesse Siffledeen, Sunny Singh, Scott M. Shulman, John Igoe, Tobias Heatta-Speicher, Claudia Leitner, Chia Hui Chung, Laura Targownik
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Low-Dose Aspirin Use Does Not Increase Disease Activity in Pregnant Patients with Inflammatory Bowel Disease Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-16
Abstract Background The adverse effects of non-steroidal anti-inflammatory (NSAID) drugs on the gastrointestinal system are well recognized, but the effect of NSAID use on disease activity patients with inflammatory bowel disease (IBD) remains unresolved. Low-dose aspirin (LDA) is recommended for all pregnant patients with risk factors for developing preeclampsia, including autoimmune conditions. As
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Comparative Analysis of Enbloc or Piecemeal Removal After Enbloc Resection of Gastrointestinal Stromal Tumors Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-14 Jing-wen Zhang, Chang-qing Guo, Shan-shan Zhu, Ghulam Nabi, Nan Dai, Xiao-yu Wan, Ping Liu, Fang-bin Zhang, Yang Fu, Xin-gung Cao
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Impact of COVID-19 Treatment on Real-World Outcomes in Inflammatory Bowel Disease Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-11 Laura C. Sahyoun, Jonathan Fetene, Chandler McMillan, Petr Protiva, Badr Al Bawardy, Jill K. J. Gaidos, Deborah Proctor
Background While there are multiple safe and effective agents for COVID-19 treatment, their impact in inflammatory bowel disease (IBD) remains uncertain. Aims Our objective was to assess the effects of these therapies on both IBD and COVID outcomes. Methods A single-center retrospective study of adult patients with IBD who contracted COVID-19 between 12/2020 and 11/2022 was performed. Patients were
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Interleukin-22 Alleviates Caerulein-Induced Acute Pancreatitis by Activating AKT/mTOR Pathway Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-11 Xinjuan Fu, Zhigang Xiu, Qianqian Xu, Rui Yue, Hongwei Xu
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Like a Rolling (Gall)Stone: Optimal Treatment of Gallstone Obstruction of the Sigmoid Colon Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-11
Abstract Background Sigmoid gallstone ileus is a rare complication of cholelithiasis, accounting for 1–4% of all cases of large-bowel obstruction. This is a highly morbid, and often fatal, condition due to its challenging diagnosis and late presentation. Case presentation We report a case of a 90-year-old woman admitted to Emergency Department with abdominal pain and large-bowel obstruction due to
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Hospital-Level Care at Home for Patients with Cirrhosis Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-11 Olivia Kahn-Boesel, Henry Mitchell, Lucinda Li, Ennie Zhu, Areej El-Jawahri, David Levine, Nneka N. Ufere
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Assessment of the Learning Curve for a Single-Use Disposable Duodenoscope Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-11
Abstract Background and Aims In response to documented duodenoscope-related infectious outbreaks of multidrug-resistant organisms, the Food and Drug Administration has recommended a transition to duodenoscopes with innovative designs, including duodenoscopes with disposable components or fully disposable duodenoscopes. We aim to characterize the learning curve (LC) for a single-use disposable duodenoscope
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Successful Treatment of Recurrent Clostridioides difficile Infection Using a Novel, Drinkable, Oral Formulation of Fecal Microbiota Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-08 Michael J. Sadowsky, Michael Matson, Prince P. Mathai, Maradi Pho, Christopher Staley, Clayton Evert, Melissa Weldy, Alexander Khoruts
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Food-Related Quality of Life and Its Predictors in Inflammatory Bowel Disease Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-08 Raquel Oliveira, Viviana Martins, Helena Tavares de Sousa, Joana Roseira
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Bile Culture May Guide Antibiotic Stewardship in Acute Bacterial Cholangitis Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-08 John Titus George, Ajith Thomas, Rajeeb Jaleel, G. Jackwin Sam Paul, Anoop John, Reuben Thomas Kurien, Sudipta Dhar Chowdhury, Ebby George Simon, A. J. Joseph, Amit Kumar Dutta
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Development and Validation of Case-Finding Algorithms to Identify Pancreatic Cancer in the Veterans Health Administration Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-07 Catherine Mezzacappa, Navid Rahimi Larki, Melissa Skanderson, Lesley S. Park, Cynthia Brandt, Ronald G. Hauser, Amy Justice, Yu-Xiao Yang, Louise Wang
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Healthcare Resource Utilization and Goals of Care Discussions in Patients with Cirrhosis and Acute Kidney Injury Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-07
Abstract Background Patients with cirrhosis and acute kidney injury (AKI) are critically ill and have high health care resource utilization (HCRU). The impact and timing of goals of care discussions on HCRU are not well described. Methods 221 patients enrolled in a prospective cohort study of patients admitted with AKI and cirrhosis were reviewed. Documentation and timing of a goals of care discussions
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Development of a Serum-Based MicroRNA Signature for Early Detection of Pancreatic Cancer: A Multicenter Cohort Study Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-07 Jing Huang, Ge Gao, Yang Ge, Jianzhou Liu, Hongtu Cui, Ren Zheng, Jialin Wang, Si Wang, Vay Liang Go, Shen Hu, Yefu Liu, Minwei Yang, Yongwei Sun, Dong Shang, Yantao Tian, Zhigang Zhang, Zhongyuan Xiang, Hongyang Wang, Junchao Guo, Gary Guishan Xiao
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Endoscopic Resection for Colonic Angiomas Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-06 Wei Yang, Binbin Gu, Dan Li, Jiahui Wang, Jinshun Zhang
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Comet Tail Artifacts in Pseudocyst on Endoscopic Ultrasound Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-06 Surinder Singh Rana, Rajesh Gupta
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The Future is Bright (Red) for Hemostasis of Peptic Ulcers Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-06 Kenneth W. Hung
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Ulcer Bleeding in the United States: Epidemiology, Treatment Success, and Resource Utilization Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-06 Hata Mujadzic, Shayan Noorani, Philip J. Riddle, Yichen Wang, Gracelyn Metts, Tania Yacu, Marwan S. Abougergi
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Intestinal Rehabilitation Program for Adult Patients with Intestinal Failure: A 20-Year Analysis of Outcomes in the Single-Center Experience at a Tertiary Hospital Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-06
Abstract Background & Aims The intestinal rehabilitation program (IRP) is a specialized approach to managing patients with intestinal failure (IF). The goal of IRP is to reduce the patient’s dependence on parenteral nutrition by optimizing nutrition intake while minimizing the risk of complications and providing individualized medical and surgical treatment. We aimed to provide a thorough overview
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Gastrointestinal Characteristics of Constipation from the Perspectives of Microbiome and Metabolome Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-06 Huimin Wang, Di Zhao, Senyan Wang, Huanle Liu, Sijun Zhao, Zhenyu Li, Xuemei Qin, Xiaojie Liu
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Kinesin Family Member-18A (KIF18A) Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-06 Jihua Ren, Xinyan Yao, Minli Yang, Shengtao Cheng, Daiqing Wu, Kexin Xu, Ranran Li, Han Zhang, Dapeng Zhang
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Factors Underlying the Difference in Response to Fecal Microbiota Transplantation Between IBS Patients with Severe and Moderate Symptoms Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-06
Abstract Background Previous studies showed that patients with Severe IBS respond better to fecal microbiota transplantation (FMT) than do those with Moderate IBS. Aims The present study aimed to determine the effects of the transplant dose, route of administering it and repeating FMT on this difference. Methods This study included 186 patients with IBS randomized 1:1:1 into groups with a 90-g transplant
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Cholecystokinin-Induced Duodenogastric Bile Reflux Increases the Severity of Indomethacin-Induced Gastric Antral Ulcers in Re-fed Mice Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-06 Hiroshi Satoh, Yasutada Akiba, Tetsuro Urushidani, Jonathan D. Kaunitz
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A Dedicated Celiac Disease Program Improves Celiac Quality Care Metrics and Short-Term Outcomes in Real Life Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-05
Abstract Background and Aims Dedicated multidisciplinary programs in gastroenterology are emerging with the goal to improve care. There is little information about the effects of a celiac disease program on disease-related quality care metrics and outcomes. We aimed to compare quality care metrics, symptom resolution, and serological response among patients diagnosed and treated in a celiac disease
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Ameliorative Effects of Larazotide Acetate on Intestinal Permeability and Bacterial Translocation in Acute Pancreatitis Model in Rats Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-05 Doğu Karahan, Muhsin Murat Muhip Harputluoglu, Mehmet Gul, Ayten Gunduz, Fatma Ozyalin, Feyza İnceoğlu, Deniz Tikici, İsmet Yılmaz, Basri Satilmis
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Insulin Resistance/Sensitivity Measures as Screening Indicators of Metabolic-Associated Fatty Liver Disease and Liver Fibrosis Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-04 Mohammad E. Khamseh, Mojtaba Malek, Soodeh Jahangiri, Sohrab Nobarani, Azita Hekmatdoost, Marieh Salavatizadeh, Samira Soltanieh, Haleh Chehrehgosha, Hoda Taheri, Zeinab Montazeri, Fereshteh Attaran, Faramarz Ismail-Beigi, Fariba Alaei-Shahmiri
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Single Versus Second Observer vs Artificial Intelligence to Increase the ADENOMA Detection Rate of Colonoscopy—A Network Analysis Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-04 Manesh Kumar Gangwani, Hossein Haghbin, Rizwan Ishtiaq, Fariha Hasan, Julia Dillard, Fouad Jabbar, Dushyant Singh Dahiya, Hassam Ali, Shaharyar Salim, Wade Lee-Smith, Amir Sohail, Sumant Inamdar, Muhammad Aziz, Benjamin Hart
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Contribution of High Body Mass Index to the Global Burden of Esophageal Cancer: A Population-Based Study from 1990 to 2019 Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-03 Wenjie Li, Wei Wang
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Successful Removal of Gallbladder Stones Under Direct Visualization of Single-Operator Peroral Cholangioscopy (with Video) Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-02 Hai Yun Shi, Min Si Zhou, Chun Tao Liu, Ming Ji, Jing Wu
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Relationship of Age and Gender to Motility Test Results and Symptoms in Patients with Chronic Constipation Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-02 George Triadafilopoulos, Jerry D. Gardner
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Electroacupuncture Improving Intestinal Barrier Function in Rats with Irritable Bowel Syndrome Through Regulating Aquaporins Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-29 Xueling Kang, Honglin Zhang, Xiaying Li, Kai Zhang, Zhansheng Huang, Yuanyuan Li, Xiaoxuan Ren, Yemao Chai
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Cold Snare Polypectomy With or Without Submucosal Injection for Endoscopic Resection of Colorectal Polyps: A Meta-Analysis of Randomized Controlled Trials Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-28 Xiu-He Lv, Tong Liu, Zi-Jing Wang, Tao Gan, Jin-Lin Yang
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Pediatric ERCP: Evolving into an Outpatient Procedure Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-28 Monique T. Barakat, Andrew Yong-Jueen Liman, Roberto Gugig
Background While most adult ERCPs are performed on an outpatient basis, pediatric ERCPs are typically performed on an inpatient basis, or with ERCP followed by at least one night inpatient admission. We have begun performing a substantial proportion of our pediatric ERCPs on an outpatient basis, using our clinical judgment to guide the decision process. In the present study, we compare patient characteristics
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Upadacitinib as Rescue Therapy for the Treatment of Acute Severe Colitis in an Acute Care Setting Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-28
Abstract Background Inflammatory bowel disease is a chronic, relapsing, and remitting inflammatory disorder that despite advances in medical therapy often requires hospitalization for treatment of acute flares with intravenous corticosteroids. Many patients will not respond to corticosteroids and require infliximab or cyclosporine as rescue therapy. If medical therapy fails, definitive surgical management
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Endoscopic Ultrasound-Guided Pancreatic Pseudocyst Drainage Using a Novel Dilation Device with Double Guidewire Insertion Function (with Video) Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-28 Takeshi Ogura, Saori Ueno, Nobu Nishioka, Atsushi Okuda, Hiroki Nishikawa
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Nomogram for Predicting the Risk of Complications after Endoscopic Foreign Body Removal from the Adult Upper Gastrointestinal Tract Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-28 Zhe Chen, Minhao Yin, Peichen Xia, Xu Han, Hong Zhu
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Amiodarone and Dronedarone Causes Liver Injury with Distinctly Different Clinical Presentations Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-28
Abstract Objective To describe hepatotoxicity due to amiodarone and dronedarone from the DILIN and the US FDA’s surveillance database. Methods Hepatotoxicity due to amiodarone and dronedarone enrolled in the U.S. Drug Induced Liver Injury Network (DILIN) from 2004 to 2020 are described. Dronedarone hepatotoxicity cases associated with liver biopsy results were obtained from the FDA Adverse Event Reporting
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Bariatric Nutritional Intervention in Obese Patients with Compensated Liver Cirrhosis: A Four-Year Prospective Study Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-27
Abstract Background Obesity and liver cirrhosis represent significant health challenges, often leading to various complications. Aims This prospective study aimed to investigate the impact of a four-year bariatric intervention, focusing on adherence to the Mediterranean Diet, on anthropometric, hematologic, and biochemical parameters in obese patients with compensated liver cirrhosis. Additionally