样式: 排序: IF: - GO 导出 标记为已读
-
Psychological well-being of children and adolescents with inflammatory bowel disease. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-04-17 Laura Vekara, Saija Kantanen, Kaija-Leena Kolho, Kati Räsänen, Timo Lakka, Heini Huhtala, Eija Piippo-Savolainen, Pekka Arikoski, Pauliina Hiltunen
Prior studies on the psychological well-being in pediatric inflammatory bowel disease (PIBD) have reported controversial results. Our aim was to compare the psychological well-being and lifestyle factors in patients with PIBD and their controls and to assess the role of contributing disease characteristics.
-
Correlating neighborhood-level deprivation and pediatric metabolic dysfunction-associated steatotic liver disease. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-04-16 Nicole E Hickman, Mason Price, Noe C Crespo, Ariel E Feldstein
The primary objective of this study is to further explore associations between social influencers of health and markers of disease severity at the time of presentation of patients with pediatric metabolic dysfunction-associated steatotic liver disease (MASLD) using neighborhood-level Area Deprivation Index (ADI) scores.
-
Role of high-volume plasmapheresis in the management of paediatric acute liver failure. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-04-16 Johannes Hilberath, Vittoria Camelli, Christiane Hofer, Steffen Hartleif, Silvio Nadalin, Maren Peters, Matthias Kumpf, Andrea Bevot, Matthias Zirngibl, Marcus Weitz, Ekkehard Sturm
Paediatric acute liver failure (PALF) is a life-threatening disease. Management aims to support hepatic regeneration or to bridge to liver transplantation. High-volume plasmapheresis (HVP) removes protein-bound substances, alleviates inflammation, and improves survival in adult acute liver failure. However, experience with HVP in PALF is limited. Aim of this study is to report on feasibility, safety
-
Esophageal food bolus impaction in pediatric age. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-04-16 Paolo Quitadamo, Antonella Pascarella, Piergiorgio Gragnaniello, Sara Isoldi, Cristina Bucci, Rossella Turco, Giovanna Puoti, Silvia Furio, Mariano Caldore, Giovanni Di Nardo
Esophageal food impaction (EFI) is the sudden onset of dysphagia that occurs when a food bolus becomes lodged in the esophagus, requiring endoscopic removal. Scientific data on the prevalence and causes of EFI in children is lacking. The aim of this study was to provide further insights into EFI episodes in children.
-
The prevalence and predictors of metabolic dysfunction-associated steatotic liver disease and fibrosis/cirrhosis among adolescents/young adults. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-04-16 Brandon J Perumpail, Richie Manikat, Karn Wijarnpreecha, George Cholankeril, Aijaz Ahmed, Donghee Kim
We investigated the current prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) and fibrosis/cirrhosis and identified at-risk populations for MASLD and MASLD-related fibrosis among US adolescents and young adults in the United States.
-
Esophago-gastric junction findings on high resolution impedance manometry in children with esophageal atresia. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-04-16 Sharman P Tan Tanny, Nicholas D Senior, Assia Comella, Lisa McCall, John M Hutson, Sue Finch, Mark Safe, Warwick J Teague, Taher I Omari, Sebastian K King
Using high resolution impedance manometry (HRIM), this study characterized the esophago-gastric junction (EGJ) dynamics in children with esophageal atresia (EA).
-
Formula modifications to the Crohn's disease exclusion diet do not impact therapy success in paediatric Crohn's disease. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-04-16 Emma Landorf, Paul Hammond, Rammy Abu-Assi, Samuel Ellison, Terry Boyle, Annabel Comerford, Richard Couper
The Crohn's disease exclusion diet (CDED) + partial enteral nutrition (PEN) is an emerging diet used to induce clinical remission in children with active Crohn's disease (CD). This study aims to determine the effectiveness of using the CDED+PEN to induce clinical remission in an Australian group of children with active CD using different PEN formulas and incorporating patient dietary requirements.
-
"An urgent need for transition of care programs for adolescents and young adults with neurogastroenterology and motility disorders". J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-04-16 Sharon Wolfson, Dhiren Patel, Erin Toto, Julie Khlevner, Neha R Santucci
Transition of Care for Adolescents and Young Adults (AYA) with Neurogastroenterology & Motility (NGM) Disorders.
-
Plasma lipids paediatric reference intervals: Indirect estimation using a large 14-year database. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-04-12 Paola Galozzi, Andrea Padoan, Carlo Moretti, Ada Aita, Daniela Basso
Establishing direct reference intervals (RIs) for paediatric patients is a very challenging endeavour. Indirect RIs can address this problem, using existing clinical laboratory databases from real-world data research. Compared to the traditional direct method, the indirect approach is highly practical, widely applicable, and low-cost. Considering the relevance of dyslipidemia in the paediatric age
-
Prevalence and clinical features of chronic uveitis in pediatric inflammatory bowel diseases: A nationwide study. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-04-09 Valerio Maniscalco, Luca Scarallo, Marina Aloi, Patrizia Alvisi, Lorenzo Norsa, Giovanna Zuin, Gabriele Simonini, Paolo Lionetti
Inflammatory bowel diseases (IBD) encompass a group of chronic inflammatory disorders primarily affecting the gastrointestinal tract but capable of impacting various organs, including the eye, with uveitis being the most common ocular condition. We assessed uveitis prevalence and clinical features in a nationwide cohort of pediatric IBD. Among 4229 cases, six patients (four Crohn's disease, one ulcerative
-
Ocular endothelial dysfunction in pediatric inflammatory bowel disease. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-04-08 Giovanni Di Nardo, Mariachiara Di Pippo, Letizia Zenzeri, Maurizio Mennini, Marisa Piccirillo, Silvia Furio, Giovanna Quatrale, Melania Evangelisti, Pasquale Parisi, Livia Lucchini, Alessandro Ferretti, Maria Pia Villa, Gianluca Scuderi, David Sarzi Amadè, Solmaz Abdolrahimzadeh
To assess ocular microvasculature changes using optical coherence tomography angiography (OCTA) in pediatric patients with inflammatory bowel disease (IBD).
-
Mineral supplementation for very preterm infants fed fortified human milk. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-04-08 Marie Bendix Simonsen, Susanne Soendergaard Kappel, Lise Aunsholt, Sören Möller, Per Torp Sangild, Gitte Zachariassen
The safety and feasibility of human milk fortification with bovine colostrum (BC) were investigated in very preterm infants (FortiColos trial, NCT03537365). The BC product contained lower calcium, phosphate, and iron levels compared to the conventional fortifier (CF). We tested whether fortification with BC plus extra phosphate was sufficient to support the infants' mineral status assessed by blood
-
Dupilumab in adolescent eosinophilic esophagitis: Experience with fibrostenosis and EGID with esophageal involvement. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-04-08 Robert Becker, Mariah Rigsby, Mariko Suchi, Diana G Lerner, Ankur Chugh
We evaluated patients aged 12-20 on dupilumab 300 mg weekly for treatment of eosinophilic esophagitis (EoE) who had ≥1 follow-up endoscopy at a tertiary care pediatric hospital (n = 18). Fifty percent had inflammatory EoE (n = 9), 22% had fibrostenotic EoE (n = 4), and 28% had non-EoE eosinophilic gastrointestinal disease (EGID) with esophageal involvement (n = 5). Ninety-four percent discontinued
-
Out-of-pocket expenses and parent reported quality of life in children with cow's milk protein allergy in Bogotá, Colombia. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-04-08 Isabella Fakih-Botero, Maria Camila Cerchiaro-Mejia, Maria Juliana Rusinque, María Alejandra Palacios-Ariza, Clara Eugenia Plata-Garcia, Stephania Peña-Hernández
To identify the out-of-pocket expenses and parent-reported quality of life (QoL) of children with a diagnosis of cow's milk protein allergy (CMPA) between the ages of 0 and 5 using the Food Allergy Quality of Life Questionnaire - Parent Form.
-
Reevaluating the FDA's warning against the use of probiotics in preterm neonates: A societal statement by ESPGHAN and EFCNI. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-04-04 Chris H P van den Akker, Nicholas D Embleton, Alexandre Lapillonne, Walter A Mihatsch, Silva Salvatore, Roberto B Canani, Ener C Dinleyici, Magnus Domellöf, Alfredo Guarino, Pedro Gutiérrez-Castrellón, Iva Hojsak, Flavia Indrio, Alexis Mosca, Rok Orel, Johannes Hans B van Goudoever, Zvi Weizman, Silke Mader, Luc J I Zimmermann, Raanan Shamir, Yvan Vandenplas, Hania Szajewska
The recent advisory issued by the United States Food and Drug Administration, cautioning against the routine administration of probiotics in preterm neonates, has sparked a lively debate within the scientific community. This commentary presents a perspective from members of the Special Interest Group on Gut Microbiota and Modifications within the European Society for Paediatric Gastroenterology, Hepatology
-
Distinct effects of racial and socioeconomic disparities on biliary atresia diagnosis and outcome. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-04-03 Julie Bonn, Kristen Gamm, Teresa Ambrosino, Sarah H Orkin, Amy Taylor, Anna L Peters
To identify and distinguish between racial and socioeconomic disparities in age at hepatology care, diagnosis, access to surgical therapy, and liver transplant-free survival in patients with biliary atresia (BA).
-
Transanal irrigation in children with functional constipation: A systematic review and meta-analysis. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-04-01 Rishi Bolia, Akhil Goel, Nikhil Thapar
Refractory functional constipation is a challenging condition to manage in children. The use of transanal irrigation (TAI) is well reported in children with neurological disorders as well as anorectal malformations but less so in children with functional disorders of defecation. The objective of our study was to evaluate the effectiveness, safety and outcomes of TAI in children with functional constipation
-
Poorly controlled pediatric type 1 diabetes mellitus is a risk factor for metabolic dysfunction associated steatotic liver disease (MASLD): An observational study. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-04-01 Florian Koutny, Dagobert Wiemann, Alexander Eckert, Svenja Meyhöfer, Maria Fritsch, Angeliki Pappa, Susanna Wiegand, Marc Weyer, Michael Wurm, Daniel Weghuber, Reinhard W Holl
Recent studies have suggested a link between type 1 diabetes mellitus (T1D) and metabolic dysfunction associated steatotic liver disease (MASLD) in children and adolescent, but longitudinal evidence is lacking. This study aimed to investigate the potential association between poorly controlled T1D and elevated alanine aminotransferase (ALT), serving as a proxy for MASLD in children and adolescents
-
Reverse-engineered exclusive enteral nutrition in pediatric Crohn's disease: A pilot trial. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-04-01 Dale Lee, Kim Braly, Mason Nuding, Ian Braly, Courtney Hopp, Heather Twible, Christopher Pope, Hillary S Hayden, Luke Hoffman, Hengqi Zheng, Ghassan Wahbeh, David L Suskind
In pediatric Crohn's disease (CD), commercial formulas used as exclusive enteral nutrition (EEN) are effective at inducing remission. This study aims to assess the impact of a whole-food blended smoothie as EEN on CD activity and the intestinal microbiome.
-
Eosinophilic esophagitis: Does age matter? J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-04-01 Donnchadh O'Sullivan, Maria Camila Cardenas, Luisa Ricaurte, Roger Moreira, Amy L Weaver, Puanani Hopson, Imad Absah
Eosinophilic esophagitis (EoE) is often diagnosed in school-age children between 6- and 9-year-old. There is less known about those who are diagnosed with EoE that are younger than 6 years old. The objective of this study is to compare clinical presentation, comorbidities, and outcomes based on age at diagnosis of EoE.
-
Clinical trial: Randomized controlled trial of linaclotide in children aged 6-17 years with functional constipation. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-27 Carlo Di Lorenzo, Samuel Nurko, Jeffrey S Hyams, Gerardo Rodriguez-Araujo, Cristina Almansa, Valentina Shakhnovich, Miguel Saps, Michael Simon
Linaclotide, a guanylate cyclase-C agonist, was recently approved in the United States for treatment of children 6-17 years old with functional constipation (FC). This study evaluated the safety and efficacy of several linaclotide doses in children 6-17 years old with FC.
-
Paediatric steatotic liver disease has unique characteristics: A multisociety statement endorsing the new nomenclature. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-26 Pietro Vajro, , , , , ,
Nonalcoholic fatty liver disease (NAFLD) has been a commonly used term and diagnosis in paediatric hepatology, gastroenterology, and endocrinology clinics for over 30 years. A multisociety Delphi process has determined a new name "Steatotic Liver Disease" (SLD) as the overarching term for disorders associated with hepatic lipid accumulation. Our Societies give our support to steatotic liver disease
-
Parenteral nutrition emulsion inhibits CYP3A4 in an iPSC derived liver organoids testing platform. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-26 Sean P Harrison, Saphira F Baumgarten, Maria E Chollet, Benedicte Stavik, Anindita Bhattacharya, Runar Almaas, Gareth J Sullivan
Parenteral nutrition (PN) is used for patients of varying ages with intestinal failure to supplement calories. Premature newborns with low birth weight are at a high risk for developing PN associated liver disease (PNALD) including steatosis, cholestasis, and gallbladder sludge/stones. To optimize nutrition regimens, models are required to predict PNALD.
-
Meal related symptoms in youth with chronic abdominal pain: Relationship to anxiety, depression, and sleep dysfunction. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-22 Achintya Benegal, Hunter Friesen, Jennifer Schurman, Jennifer Colombo, Craig Friesen
The objective of the current study was to describe meal-related symptoms in youth with chronic abdominal pain fulfilling criteria for a disorder of gut-brain interaction (DGBI) and their associations with anxiety, depression, and sleep disturbances.
-
Pediatric retrograde cricopharyngeal dysfunction diagnosed by high-resolution impedance manometry. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-22 Lev Dorfman, Khalil El-Chammas, Sherief Mansi, Kahleb Graham, Ajay Kaul
The inability to burp, known as retrograde cricopharyngeal dysfunction (R-CPD), was initially described in adults. The proposed clinical diagnostic criteria for R-CPD include belching inability, abdominal bloating and discomfort/nausea, postprandial chest pain, and involuntary noises. Botulinum toxin injection to the cricopharyngeal muscle has been reported to be beneficial. High-resolution esophageal
-
Prevalence of eosinophilic gastrointestinal diseases in children with short bowel syndrome: A single center study. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-21 Nicole Du, Clarivet Torres
Patients with short bowel syndrome (SBS) have multiple risk factors for eosinophilic gastrointestinal diseases (EGIDs) including increased risk for intestinal dysbiosis and food allergy compared to their counterparts with normal anatomy. However, there is limited data on the prevalence of EGIDs in children with SBS. We aimed to define the prevalence of EGIDs in an SBS cohort and its association with
-
Awareness, referral and age at Kasai surgery for biliary atresia in Europe: A survey of the Quality-of-Care Task Force of ESPGHAN. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-18 Florence Lacaille, Emanuele Nicastro, Piotr Czubkowski, Cristina Campos Gonçalves, Thu Giang Le Thi, Sibylle Koletzko
To identify infants with biliary atresia (BA), European Society of Paediatric Gastroenteroloy and Nutrition (ESPGHAN)/North American Society of Pediatric Gastroenteroloy and Nutrition (NASPGHAN) guidelines recommend measurement of conjugated/direct bilirubin in infants with prolonged jaundice and using a stool colour card (SCC). The 'Quality of Care' Task Force of ESPGHAN performed two surveys to assess
-
Real-world effectiveness of ustekinumab and vedolizumab in TNF-exposed pediatric patients with ulcerative colitis. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-14 Perseus V Patel, Amy Zhang, Balu Bhasuran, Vignesh G Ravindranath, Melvin B Heyman, Sofia G Verstraete, Atul J Butte, Michael J Rosen, Vivek A Rudrapatna
Vedolizumab (VDZ) and ustekinumab (UST) are second-line treatments in pediatric patients with ulcerative colitis (UC) refractory to antitumor necrosis factor (anti-TNF) therapy. Pediatric studies comparing the effectiveness of these medications are lacking. Using a registry from ImproveCareNow (ICN), a global research network in pediatric inflammatory bowel disease, we compared the effectiveness of
-
Endoscopic and histologic utility of transnasal endoscopy in pediatric eosinophilic esophagitis. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-14 Eliana Shaul, Kanak V Kennedy, Zachary C Spergel, Shanaz Daneshdoost, Mark Mahon, Shivani Thanawala, Jonathan M Spergel, Benjamin Wilkins, Matthew J Ryan, Amanda B Muir
Unsedated transnasal endoscopy (TNE) is an alternative method of examining the esophageal mucosa in pediatric patients with eosinophilic esophagitis (EoE), reducing cost, time, and risk associated with frequent surveillance esophagogastroduodenoscopies (EGD). Adequacy of transnasal esophageal biopsies for the evaluation of eosinophilic esophagitis histologic scoring system (EoEHSS) has not yet been
-
Longitudinal screening of HLA-risk and HLA-nonrisk children for celiac disease to age 15 years: CiPiS study. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-13 Michaela Boström, Charlotte Brundin, Sara Björck, Daniel Agardh
Autoantibodies against tissue transglutaminase (tTG) are serological markers of celiac disease. The aim was to study the applicability of human leukocyte antigen (HLA)-genotyping and tTG autoantibodies in the screening of celiac disease in a longitudinal birth cohort followed to age 15 years.
-
Impact of COVID-19 on paediatric chronic intestinal failure: A tertiary care children's hospital experience. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-13 Johannes Hilberath, Anna-Sophia Mast, Simon Scherer, Jörg Fuchs, Johannes Schulte, Ekkehard Sturm, Steven Warmann, Christoph Slavetinsky
Paediatric patients with intestinal failure (IF) are at risk for both gastrointestinal (GI) and systemic complications, thus depending on a functioning network of multidisciplinary care. Data on the clinical impact of coronavirus disease 2019 (COVID-19) or the pandemic-related restrictions are limited. We aimed to analyse the clinical course of COVID-19 in children with IF, and to evaluate the perceived
-
Shear-wave elastography for monitoring Fontan-associated liver disease: A prospective cohort study. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-13 Rishi Bolia, Sara Alremawi, Charlton Noble, Robert Justo, Cameron Ward, Peter J Lewindon
The spectrum of Fontan-associated liver disease (FALD) varies from abnormal liver function tests to fibrosis and even cirrhosis. In this prospective study, we evaluated the role of shear-wave elastography (SWE) in predicting the presence of advanced FALD. Forty-eight patients (30 males, 13.9 [6-21] years) with a Fontan circulation were evaluated at 8.3 (2.1-18.7) years since the Fontan surgery. The
-
Measurement practices of alanine aminotransferase in children: Temporal changes and etiology for increased values. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-13 Linnea Aitokari, Pauliina Hiltunen, Heini Huhtala, Kalle Kurppa, Laura Kivelä
Data on alanine aminotransferase (ALT) measurement practices and diagnoses associated with increased values are limited. We evaluated these issues by collecting ALT measurements from 1- to 16-year-old patients investigated in 1992-2018 in a tertiary center. Diagnoses were gathered in 2008-2018. Altogether 145,092 measurements from 28,118 children were taken 42% undergoing repeated testing. Testing
-
Gluten-free diet adherence in pediatric celiac patients: Evaluating CDAT questionnaire and test for gluten detection in urine. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-13 Carolina R Lins E Mello, Gisélia A P da Silva, Manuela T C Lins, Margarida M de C Antunes
This study aimed to evaluate the contributions of the Adapted Celiac Dietary Adherence Test (CDAT) and the Rapid Urinary Gluten Detection Test (u-GIP) in assessing gluten-free diet adherence in children and adolescents with celiac disease.
-
Combination biologic therapy in pediatric inflammatory bowel disease: Safety and efficacy over a minimum 12-month follow-up period. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-13 Magdalena Wlazlo, Monika Meglicka, Anna Wiernicka, Marcin Osiecki, Malgorzata Matuszczyk, Jaroslaw Kierkus
The severe course of inflammatory bowel diseases (IBDs) refractory to advanced therapies in children results in the search for new therapeutic methods. The aim of this study was to evaluate the efficacy and safety of dual therapy with biologics in a cohort of children with IBD.
-
Persistent and newly developed gastrointestinal symptoms after surgery for intestinal malrotation in children: Dysmotility or disorders of gut and brain interaction? J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-07 Dhiren Patel, Darnna Banks, Bindi Hira, Madeline Ford, Lusine Ambartsumyan, Leonel Rodriguez
Surgery for intestinal malrotation (IM) aims to correct the defect and improve symptoms; however, many have persistent gastrointestinal (GI) symptoms postoperatively. We evaluated the incidence, clinical presentation, and long-term outcomes of children with surgically repaired IM and its possible association with disorders of gut and brain interaction (DGBI).
-
Analysis of missed clinic visits, preferred languages, and telemedicine in a pediatric gastroenterology practice. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-07 Bonnie Crume, Mohamed Suufi, Gloria Nabbosa, Lori Parker-Hartigan, Ashley McBride, Paul A Rufo, McGreggor Crowley
Previous studies have demonstrated a relationship between socioeconomic disparities and missed clinic visits (MCV). However, the relationship between patient-preferred language and MCVs, particularly with respect to telemedicine, remains relatively underexplored. We sought to characterize the associations between MCV and patient-level predictors, including preferred language, in a large single-center
-
Nut consumption during pregnancy is associated with decreased risk of peer problems in 5-year-old Japanese children. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-07 Mai Quynh Nguyen, Yoshihiro Miyake, Keiko Tanaka, Shizuka Hasuo, Yoshitaka Nakamura, Hitomi Okubo, Satoshi Sasaki, Masashi Arakawa
Nuts are nutrient-dense foods rich in unsaturated fatty acids, protein, dietary fiber, vitamins, and minerals. The present prebirth cohort study examined the association between maternal nut intake during pregnancy and the risk of childhood behavioral problems in 5-year-old Japanese children.
-
A multicenter registry study on percutaneous electrical nerve field stimulation for pediatric disorders of gut-brain interaction. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-07 Ashish Chogle, Khalil El-Chammas, Neha Santucci, Monica Grimm, Lev Dorfman, Kahleb Graham, Daniel R Kelly, Jason E Dranove, Rachel Rosen, Samuel Nurko, Joseph Croffie, Keshawadhana Balakrishnan, Eric H Chiou, Liyun Zhang, Pippa Simpson, Katja Karrento
Percutaneous electrical nerve field stimulation (PENFS) has demonstrated promise in single-center trials for pediatric abdominal pain-related disorders of gut-brain interaction (DGBI). Our aim was to explore efficacy of PENFS as standard therapy for DGBI in a registry involving multiple pediatric gastroenterology referral centers.
-
Catheter salvage from central line-related bloodstream infections in pediatric intestinal failure. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-07 Catherine Larson-Nath, Linder Wendt, Riad Rahhal
Patients with intestinal failure require central venous access which puts them at risk for central line-associated bloodstream infections (CLABSI). Maintaining vascular patency is critical for this population to receive nutrition support. When CLABSIs occur line salvage can help maintain vascular access. The aim of this study is to assess factors associated with safe and successful central venous catheter
-
Parental perspectives on pediatric inflammatory bowel disease: Unraveling concerns, and study participation willingness. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-01 Adi Eindor-Abarbanel, Noa Pinchevski, Tzippora Shalem, Netanel Agajany, Nimrod Ophir, Batya Weiss, Efrat Broide, Vered Richter
The impact of disease burden extends beyond pediatric inflammatory bowel disease (IBD) patients to include their parents. Previous studies, predating the biologic era, have highlighted parental concerns about potential side effects associated with IBD medications. However, there is a notable gap in the literature regarding parents' perceptions of clinical studies involving pediatric IBD patients. This
-
Effect of lactase supplementation on infant colic: Systematic review of randomized controlled trials. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-01 Anna Kozłowska-Jalowska, Agata Stróżyk, Andrea Horvath, Hania Szajewska
To systematically review evidence on the efficacy and safety of using a lactase supplementation for managing infant colic. The MEDLINE, EMBASE, and Cochrane Library databases were searched (up to September 2023) for randomized controlled trials (RCTs) comparing oral lactase supplementation with placebo or no intervention in infants younger than 6 months old with infant colic. The risk of bias was assessed
-
Proton pump inhibitors, antibiotics, and atopy increase the risk of eosinophilic esophagitis in children with esophageal atresia. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-26 Tiffany C Tang, Steven T Leach, Usha Krishnan
To determine whether proton pump inhibitor (PPI) exposure is associated with an increased risk of developing eosinophilic esophagitis (EoE) in children with esophageal atresia (EA).
-
A serum-induced gene signature in hepatocytes is associated with pediatric nonalcoholic fatty liver disease. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-23 T Hang Nghiem-Rao, Jethro S Johnson, Amy Pan, Samantha N Atkinson, Cynthia Behling, Pippa M Simpson, Mary L Holtz, George M Weinstock, Jeffrey B Schwimmer, Nita H Salzman
Pediatric nonalcoholic fatty liver disease (NAFLD) is a growing problem, but its underlying mechanisms are poorly understood. We used transcriptomic reporter cell assays to investigate differences in transcriptional signatures induced in hepatocyte reporter cells by the sera of children with and without NAFLD.
-
The role of high-resolution impedance manometry to identify rumination syndrome in children with unexplained foregut symptoms. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-22 Maria Giovanna Puoti, Mark Safe, Nikhil Thapar, Teresa Di Chio, Elena Sofia Pieri, Kornilia Nikaki, Keith Lindley, Anna Rybak, Osvaldo Borrelli
Diagnosis of rumination syndrome (RS) relies on Rome IV criteria. Oesophageal high-resolution impedance manometry (HRIM) can objectively demonstrate the episodes of rumination, but its role in the diagnostic pathway is not yet established. We aimed to demonstrate the clinical contribution of this tool for the timely diagnosis of RS and diagnostic work-up of children with unexplained foregut symptoms
-
Drawing the abdominal pain: A powerful tool to distinguish between organic and functional abdominal pain. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-22 Joachim Opp, Mia Schürmann, Andreas Jenke, Barbara Job
Abdominal pain (AP) in children imposes a large economic burden on the healthcare system. Currently, there are no reliable diagnostic tools to differentiate between organic and functional disorders. We hypothesized from previous research that the analysis of patients' graphic expression of subjective symptoms as well as their interactional behavior adds new ways to differentiate between functional
-
Growth pattern of paediatric patients affected by cow milk protein allergy fed with rice hydrolyzed formula. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-20 Rita Nocerino, Serena Coppola, Laura Carucci, Franca Oglio, Marica Cozzolino, Antonio Masino, Gulsum Ozen, Margherita Farnetano, Roberto Berni Canani
Formulas made from hydrolyzed rice proteins (HRPF) are well-tolerated plant-based alternatives to cow's milk protein (CMP)-based formulas for the dietary management of paediatric patients with CMP allergy (CMPA). Growth in patients with CMPA fed with HRPF has been evaluated in several studies with conflicting results. The aim was to evaluate the growth pattern of children with CMPA over a 12-month
-
A nomogram for predicting food allergy in infants with feeding problems and malnutrition. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-20 Fan Yang, Chunyan Zhou, Luanluan Li, Xirui Wang, Bin Wang, Yabin Hu, Yue Zhang, Chen Chen, Juan Li, Xiandan Yu
As oral food challenge (OFC) cannot be performed routinely in the general outpatient, this study aimed to construct a nomogram to predict the odds of food allergy in infants with idiopathic feeding problems and malnutrition.
-
ESPGHAN recommendations on treatment of chronic hepatitis C virus infection in adolescents and children including those living in resource-limited settings. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-18 Giuseppe Indolfi, Regino P Gonzalez-Peralta, Maureen M Jonas, Manal Hamdy-El Sayed, Björn Fischler, Etienne Sokal, Stefan Wirth, Emanuele Nicastro
Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide, with more than three million viraemic adolescents and children. Treatment of adults with HCV infection and HCV-related liver disease has advanced considerably thanks to development and improvements in therapy. Direct-acting antiviral regimens are safe and effective. Three regimens with pangenotypic activity (gle
-
Effect of maturation at birth on the clinical features of neonatal cow's milk protein allergy: A retrospective study. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-14 Motomichi Nagafuji, Satoshi Fujiyama, Ryota Ishii, Michiru Shime, Toshinori Kitatsu, Yusuke Hoshino, Yu Kanai, Junichi Arai, Yayoi Miyazono, Hidetoshi Takada
Neonatal immune regulation transitions from fetal immunity and varies with maturation status, but its role in neonatal cow's milk protein allergy (CMPA) remains unknown. We studied the association between maturation status at birth and neonatal CMPA. Clinical and laboratory data of neonates presenting with CMPA symptoms were retrospectively collected from two tertiary hospitals. Patients were assessed
-
Humoral immune response and safety of SARS-CoV-2 vaccination in very early onset inflammatory bowel disease. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-14 Arthur J Kastl, Kimberly N Weaver, Xian Zhang, Jennifer A Strople, Jeremy Adler, Judith R Kelsen, Marla C Dubinsky, Athos Bousvaros, Runa Watkins, Colin Dai, Raymond K Cross, Peter D R Higgins, Ryan Ungaro, Meenakshi Bewtra, Emanuelle A Bellaguarda, Francis A Farraye, Kelly Chun, Michael Zikry, Monique Bastidas, Margie E Boccieri, Ann Firestine, Millie D Long, Michael D Kappelman
Children with very early onset inflammatory bowel disease (VEO-IBD) may respond differently to coronavirus disease 2019 (COVID-19) immunization compared to healthy children or other patients with IBD. We recruited children with VEO-IBD <6 years of age and younger following receipt of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. Demographics, IBD characteristics, medication
-
Gut microbiota and inflammatory mediators differentiate IgE mediated and non-IgE mediated cases of cow's milk protein at diagnosis. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-12 Ana M Castro, Isabel Gutiérrez-Díaz, María L Saiz, Sandra Navarro, Marta Suárez, Ignacio Carbajal, Águeda García, Lydia Sariego, Paula Toyos, Silvia Rodríguez, Santiago Jiménez, David González, Cristina Molinos, David Pérez, Porfirio Fernández, Beatriz Suárez-Alvarez, Abelardo Margolles, Juan J Díaz, Susana Delgado
Analyze fecal and blood samples at point of diagnosis in IgE mediated cow's milk protein allergy (CMPA) and non-IgE mediated (NIM)-CMPA patients to look for potential new biomarkers.
-
Clinical outcomes and cost savings of a nonmedical switch to a biosimilar in children/young adults with inflammatory bowel disease. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-09 Megan McNicol, Mahmoud Abdel-Rasoul, Madeline G McClinchie, Grant A Morris, Brendan Boyle, Jennifer L Dotson, Hilary K Michel, Ross M Maltz
The safety, efficacy, and cost savings associated with biosimilar medications are well established. However, a lack of pediatric data exists surrounding clinical outcomes when switching from an originator to a biosimilar. Our primary aim is to evaluate clinical outcomes following a nonmedical switch from the infliximab originator to a biosimilar in children and young adults with inflammatory bowel
-
Real-world experience of maralixibat in Alagille syndrome: Novel findings outside of clinical trials. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-09 Ryan Himes, Philip Rosenthal, Natasha Dilwali, Kathryn Smith, Robert Venick, Regino P Gonzalez-Peralta
Maralixibat, an ileal bile acid transporter inhibitor, is the first drug approved by the U.S. Food and Drug Administration for the treatment of cholestatic pruritus in patients aged ≥3 months with Alagille syndrome (ALGS). Approval was based on reductions in pruritus from the pivotal ICONIC trial, information from two additional trials (ITCH and IMAGO), and long-term extension studies. Although participants
-
Genetic and acquired sucrase-isomaltase deficiency: A clinical review. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-08 Tanaz Farzan Danialifar, Bruno P Chumpitazi, Devendra I Mehta, Carlo Di Lorenzo
Genetic sucrase-isomaltase deficiency (GSID) is an inherited deficiency in the ability to digest sucrose and potentially starch due to mutations in the sucrase-isomaltase (SI) gene. Congenital sucrase-isomaltase deficiency is historically considered to be a rare condition affecting infants with chronic diarrhea as exposure to dietary sucrose begins. Growing evidence suggests that individuals with SI
-
Histopathological findings from the investigation of paediatric acute hepatitis of unknown aetiology, United Kingdom 2022. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-08 Helen Callaby, Emma McGuire, Sanjay Rajwal, Jens Stahlschmidt, Jane Hartley, Rachel M Brown, Maesha Deheragoda, Alberto Quaglia, Tommy Rampling, Catherine F Houlihan, N Claire Gordon, Colin S Brown, Ruth Simmons, Anda Samson, Sema Mandal, Tassos Grammatikopoulos, Alicia Demirjian
In 2022, there were global reports of increased numbers of acute hepatitis not explained by hepatitis A-E virus infection in children. This manuscript summarises histopathology results from 20 patients in the United Kingdom who underwent liver transplant or had a liver biopsy as part of aetiological investigations. All available histopathological samples were reviewed centrally as part of the outbreak
-
Iodine status in children with intestinal failure. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-07 Heitor Pons Leite, Eduardo Freitas Hatanaka, Giovana Sertori Galati Sabio, Nara Michelle de Araújo Evangelista, Maria Fernanda Carvalho de Camargo
Children on long-term parenteral nutrition (PN) are at high risk of iodine deficiency (ID). However, most available information comes from cross-sectional studies. We investigated the iodine status, associated factors, and prevalence of hypothyroidism in children with intestinal failure (IF) who were followed up longitudinally.
-
Home-based fecal calprotectin utilization in a general pediatric gastroenterology clinic. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-06 Melanie L Schmidt, Emma McCrady, Angus Lee, Terrence Bowerbank, Michael R Miller, Melanie Watson, Ashok Dhandapani, Jessica P Woolfson, Andréanne N Zizzo, Kevin Bax, Eileen Crowley
Remote investigation and monitoring have gained importance in ambulatory practice. A home-based fecal calprotectin (FC) test has been developed where the sample is processed and analyzed at home through a smartphone application. We aimed to assess the use of standard ELISA (sFC) versus home-based (hFC) FC testing in a general pediatric gastroenterology clinic.
-
Major basic protein is a useful marker to distinguish eosinophilic esophagitis from IBD-associated eosinophilia in children. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-05 Samantha Butzke, Shaida Nasiri-Blomgren, Diana Corao-Uribe, Zhaoping He, Zarela Molle-Rios
The incidence of eosinophilic esophagitis (EoE) is 3-5 times greater in patients with inflammatory bowel disease (IBD) compared with the general population. This study aimed to differentiate true EoE from esophageal eosinophilia in IBD patients by evaluating expression of major basic protein (MBP) and interleukin-13 (IL-13) in esophageal biopsies.
-
Efficacy of lubiprostone for functional constipation treatment in adolescents and children: Randomized controlled trial. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-05 Engy S Elkaragy, Mohammed M Shamseya, Rasha H Metwally, Eman R Mansour, Sameh A Lashen
Adolescent and pediatric functional constipation (FC) is a common clinical problem. Currently, data on lubiprostone for the treatment of pediatric FC are scarce. This study investigated the efficacy and safety of lubiprostone in the treatment of pediatric FC.