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Eosinophilic esophagitis prevalence, incidence, and presenting features: a 22-year population-based observational study from southwest Sweden Dis. Esophagus (IF 2.6) Pub Date : 2024-03-25 J Plate, T Söderbergh, J Bergqvist, C Lingblom, H Bergquist, H Larsson
Summary Eosinophilic esophagitis (EoE) is a chronic inflammatory condition of the esophagus that affects both children and adults. Symptoms in adults are mainly esophageal dysphagia, which ranges from mild symptoms to acute food bolus obstruction of the esophagus. Diagnosis is defined as symptoms of esophageal dysfunction and ≥ 15 eosinophils/high power field (HPF) in at least one of the biopsies taken
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Impact of aspirin use on rates of metastasis in patients with esophageal cancer: insights from the National Inpatient Sample Dis. Esophagus (IF 2.6) Pub Date : 2024-03-25 Jay Patel, Tejasvini Khanna, Aalam Sohal, Armaan Dhaliwal, Hunza Chaudhry, Shivam Kalra, Ishandeep Singh, Dino Dukovic, Kanwal Bains
Summary Despite advancing treatment methods, esophageal cancer (EC) maintains a high mortality rate and poor prognosis. Through various mechanisms, aspirin has been suggested to have a chemopreventive effect on EC. However, the long-term impact, particularly regarding the rate of metastasis, needs to be further elucidated. NIS 2016–2020 was used to identify adult patients (age > 18 years) with EC using
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Management of esophageal anastomotic leaks, a systematic review and network meta-analysis Dis. Esophagus (IF 2.6) Pub Date : 2024-03-25 William Murray, Mathew G Davey, William Robb, Noel E Donlon
Summary There is currently no consensus as to how to manage esophageal anastomotic leaks. Intervention with endoscopic vacuum-assisted closure (EVAC), stenting, reoperation, and conservative management have all been mooted as potential options. To conduct a systematic review and network meta-analysis (NMA) to evaluate the optimal management strategy for esophageal anastomotic leaks. A systematic review
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Pilot study evaluating salivary bile acids as a diagnostic biomarker of laryngopharyngeal reflux Dis. Esophagus (IF 2.6) Pub Date : 2024-03-25 Amanda J Krause, Madeline Greytak, Marco Kessler, Rena Yadlapati
Summary Bile acids in refluxate contribute to esophageal and laryngeal symptoms and are quantifiable. The aim of this study was to compare salivary bile acid concentrations across healthy controls and symptomatic patients (esophageal or laryngeal) with or without objective gastroesophageal reflux disease (GERD). This prospective study enrolled adults into three groups: esophageal symptoms (heartburn
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Research gap in esophageal achalasia: a narrative review Dis. Esophagus (IF 2.6) Pub Date : 2024-03-25 Edoardo Vincenzo Savarino, Renato Salvador, Matteo Ghisa, Amir Mari, Francesca Forattini, Andrea Costantini, Roberto De Giorgio, Giovanni Zaninotto
Summary In recent years, new translational evidence, diagnostic techniques, and innovative therapies have shed new light on esophageal achalasia and revamped the attention on this relatively rare motility disorder. This narrative review aims to highlight the most recent progress and the areas where further research is needed. The four senior authors identified five topics commonly discussed in achalasia
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Predictors of textbook outcome following oesophagogastric cancer surgery Dis. Esophagus (IF 2.6) Pub Date : 2024-03-25 Ganesh K Velayudham, Alexander Dermanis, Sivesh K Kamarajah, Ewen A Griffiths
Summary Textbook outcome (TO) is a composite measure representing an ideal perioperative course, which has been utilized to assess the quality of care in oesophagogastric cancer (OGC) surgery. We aim to determine TO rates among OGC patients in a UK tertiary center, investigate predictors of TO attainment, and evaluate the relationship between TO and survival. A retrospective analysis of a prospectively
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Concurrent abnormal non-acid reflux is associated with additional chronic rejection risk in lung transplant patients with increased acid exposure Dis. Esophagus (IF 2.6) Pub Date : 2024-03-24 Wai-Kit Lo, Mayssan Muftah, Hilary J Goldberg, Nirmal Sharma, Walter W Chan
Summary Acid reflux has been associated with allograft injury and rejection in lung transplant patients; however, the pathogenic role of non-acid reflux remains debated. We aimed to evaluate the impact of concurrent abnormal non-acid reflux with acid reflux on chronic rejection in lung transplant patients with acid reflux. This was a retrospective cohort study of lung transplant recipients who underwent
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Disease-specific quality of life as part of the long-term follow-up for children born with esophageal atresia in an academic unit in South Africa—a pilot study Dis. Esophagus (IF 2.6) Pub Date : 2024-03-13 C de Vos, M Dellenmark-Blom, F M Sikwete, D Sidler, L van Wyk, P Goussard
Summary As neonatal mortality rates have decreased in esophageal atresia (EA), there is a growing focus on quality of life (QoL) in these children. No study from Africa has reported on this topic. This pilot study aimed to describe disease-specific QoL in EA children and its applicability as part of long-term follow-up in an academic facility in South Africa. Disease-specific QoL in children born with
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Peroral endoscopic myotomy and its use in non-achalasia disorders Dis. Esophagus (IF 2.6) Pub Date : 2024-03-08 Arvind Rengarajan, A Aziz Aadam
Summary The aim of this review is to provide an overview of per-oral endoscopic myotomy (POEM) and its utilization in non-achalasia disorders of the esophagus. POEM, a relatively novel endoscopic technique, involves submucosal tunneling to access esophageal muscle layers, enabling selective myotomy and mitigating the consequences of motor disorders of the esophagus. POEM is an effective treatment modality
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Octreotide’s role in the management of post-esophagectomy chylothorax Dis. Esophagus (IF 2.6) Pub Date : 2024-02-23 Nathaniel Deboever, Hope Feldman, Michael Eisenberg, Mara B Antonoff, Reza J Mehran, Ravi Rajaram, David C Rice, Jack A Roth, Boris Sepesi, Stephen G Swisher, Ara A Vaporciyan, Garrett L Walsh, Wayne L Hofstetter
Summary The use of octreotide in managing intrathoracic chyle leak following esophagectomy has gained popularity in the adult population. While the benefits of octreotide have been confirmed in the pediatric population, there remains limited evidence to support its use in the adults post-esophagectomy. Thus, we performed a single-institution cohort study to characterize its efficacy. The study was
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Risk of lymph node metastasis in T1 esophageal adenocarcinoma: a meta-analysis Dis. Esophagus (IF 2.6) Pub Date : 2024-02-23 Chu Luan Nguyen, David Tovmassian, Anna Isaacs, Gregory L Falk
Summary Patients with early (T1) esophageal adenocarcinoma (EAC) are increasingly having definitive local therapy endoscopically. Endoscopic resection is not able to pathologically stage or treat lymph node metastasis (LNM). Accurate identification of patients having nodal metastasis is critical to select endoscopic therapy over surgery. This study aimed to define the risk of LNM in T1 EAC. A meta-analysis
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Current aspects in the management of esophageal trauma: a systematic review and proportional meta-analysis Dis. Esophagus (IF 2.6) Pub Date : 2024-02-17 Dimitrios Papaconstantinou, Emmanouil I Kapetanakis, Adam Mylonakis, Spyridon Davakis, Efstathios Kotidis, Evangelos Tagkalos, Ioannis Rouvelas, Dimitrios Schizas
Summary Trauma-related esophageal injuries (TEIs) are a rare but highly lethal condition. The presentation of TEIs is very diverse depending on the location and mechanism of injury (blunt vs. penetrating), as well as the presence or absence of concurrent injuries. The aim of the present systematic review and meta-analysis is to delineate the clinical features impacting TEI management. A systematic
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Randomized controlled trial of nasogastric tube use after esophagectomy: study protocol for the kinetic trial Dis. Esophagus (IF 2.6) Pub Date : 2024-02-17 Jakob Hedberg, Magnus Sundbom, David Edholm, Eirik Kjus Aahlin, Eva Szabo, Fredrik Lindberg, Gjermund Johnsen, Dag Tidemann Førland, Jan Johansson, Joonas H Kauppila, Lars Bo Svendsen, Magnus Nilsson, Mats Lindblad, Pernilla Lagergren, Michael Hareskov Larsen, Oscar Åkesson, Per Löfdahl, Tom Mala, Michael Patrick Achiam
Summary Esophagectomy is a complex and complication laden procedure. Despite centralization, variations in perioparative strategies reflect a paucity of evidence regarding optimal routines. The use of nasogastric (NG) tubes post esophagectomy is typically associated with significant discomfort for the patients. We hypothesize that immediate postoperative removal of the NG tube is non-inferior to current
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Can we predict the risk of esophageal stricture after caustic injury? Dis. Esophagus (IF 2.6) Pub Date : 2024-01-29 Philippe Zerbib, Aurore Lailheugue, Julien Labreuche, Yasmina Richa, Emeline Cailliau, Thierry Onimus, Caroline Valibouze
Summary Nonoperative management of severe caustic injuries has demonstrated its feasibility, avoiding the need for emergency esogastric resection and resulting in low mortality rates. However, leaving superficial necrosis in place could increase the risk of esophageal stricture development. Data on the risk factors of esophageal stricture secondary to caustic ingestion are scarce. The aim of our study
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Gastro-esophageal diagnostic workup before bariatric surgery or endoscopic treatment for obesity: position statement of the International Society of Diseases of the Esophagus Dis. Esophagus (IF 2.6) Pub Date : 2024-01-29 Pierfrancesco Visaggi, Matteo Ghisa, Brigida Barberio, Philip W Chiu, Ryu Ishihara, Geoffrey P Kohn, Sergey Morozov, Sarah K Thompson, Ian Wong, Cesare Hassan, Edoardo Vincenzo Savarino
Summary Obesity is a chronic and multifactorial condition characterized by abnormal weight gain due to excessive adipose tissue accumulation that represents a growing worldwide challenge for public health. In addition, obese patients have an increased risk of hiatal hernia, esophageal, and gastric dysfunction, as well as gastroesophageal reflux disease, which has a prevalence over 40% in those seeking
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Medical management of painful achalasia: a patient-driven systematic review Dis. Esophagus (IF 2.6) Pub Date : 2024-01-29 Solange Bramer, Amanda Ladell, Hannah Glatzel, Alan Moss, Majid Hashemi, Giovanni Zaninotto, Stefan Antonowicz
Summary Achalasia is a rare esophageal disorder characterized by abnormal esophageal motility and swallowing difficulties. Pain and/or spasms often persist or recur despite effective relief of the obstruction. A survey by UK charity ‘Achalasia Action’ highlighted treatments for achalasia pain/spasms as a key research priority. In this patient-requested systematic review, we assessed the existing literature
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Nature, severity, and impact of chronic oropharyngeal dysphagia following curative resection for esophageal cancer: a cross-sectional study Dis. Esophagus (IF 2.6) Pub Date : 2024-01-24 Anna Gillman, Ciaran Kenny, Michelle Hayes, Margaret Walshe, John V Reynolds, Julie Regan
Summary Chronic oropharyngeal dysphagia (COD) and aspiration after esophageal cancer surgery may have clinical significance; however, it is a rarely studied topic. In a prospective cross-sectional observational study we comprehensively evaluated the nature, severity, and impact of COD, its predictors, and the impact of the surgical approach and site of anastomosis. Forty participants were recruited
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Long-term outcomes after non-curative endoscopic resection for esophageal squamous cell carcinoma followed by additional chemoradiotherapy Dis. Esophagus (IF 2.6) Pub Date : 2024-01-24 Hourin Cho, Seiichiro Abe, Satoru Nonaka, Haruhisa Suzuki, Shigetaka Yoshinaga, Kae Okuma, Shun Yamamoto, Hiroyuki Daiko, Ken Kato, Shigeki Sekine, Narikazu Boku, Yutaka Saito
Summary Endoscopic resection (ER) of esophageal squamous cell carcinoma (ESCC) is evaluated pathologically, and additional treatment is recommended for cases resulting in non-curative resection, defined as pMM with lymphovascular invasion (LVI), pSM, or positive vertical margin. This study aimed to assess long-term outcomes and risk factors for recurrence in patients with ESCC treated with non-curative
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Evaluating analgesia strategies in patients who have undergone oesophagectomy—a systematic review and network meta-analysis of randomised clinical trials Dis. Esophagus (IF 2.6) Pub Date : 2024-01-15 Sinead Ramjit, Matthew G Davey, Caitlyn Loo, Brendan Moran, Eanna J Ryan, Mayilone Arumugasamy, William B Robb, Noel E Donlon
Summary Optimal pain control following esophagectomy remains a topic of contention. The aim was to perform a systematic review and network meta-analysis (NMA) of randomized clinical trials (RCTs) evaluating the analgesia strategies post-esophagectomy. A NMA was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-NMA guidelines. Statistical analysis was
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Clinical value of random esophageal biopsies in patients with dysphagia and normal endoscopy who are treated with a proton pump inhibitor Dis. Esophagus (IF 2.6) Pub Date : 2024-01-10 Sara Kamionkowski, Fahmi Shibli, Sherif Saleh, Sophie Trujillo, Erika Mengalle, Ali El Mokahal, Charles Thomas, Gengqing Song, Ronnie Fass
Summary Rome IV recommended esophageal biopsies in patients with dysphagia and normal endoscopy to exclude mucosal disease. Thus far, studies evaluating the utility of this recommendation remain scarce. The aims of this study were to determine the value of random esophageal biopsies in heartburn patients with dysphagia and normal endoscopy and compare the yield of random esophageal biopsies between
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Clinical study of camrelizumab combined with docetaxel and carboplatin as a neoadjuvant treatment for locally advanced oesophageal squamous cell carcinoma Dis. Esophagus (IF 2.6) Pub Date : 2024-01-08 Guo-Liang Zhang, Qi-Kun Zhu, Tian-You Ma, Chen-Gang Weng, Dan-Dan Zhang, Hui Zeng, Tao Wang, Feng Gao, Li-Li Mi, Rui Wang
Summary Herein, we aimed to evaluate the efficacy and safety of camrelizumab combined with docetaxel and carboplatin as a neoadjuvant treatment for locally advanced oesophageal squamous cell carcinoma (OSCC). Fifty-one patients with OSCC, treated from July 2020 to October 2022, were analyzed. Of them, 41 patients underwent surgery 4–8 weeks after undergoing two cycles of camrelizumab (200 mg IV Q3W)
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Are the Chicago 3.0 manometric diagnostics consistent with Chicago 4.0? Dis. Esophagus (IF 2.6) Pub Date : 2023-12-20 Angélica Tobón, Albis C Hani, Cristiam D Pulgarin, Andres F Ardila, Oscar M Muñoz, Julian A Sierra, Daniel Cisternas
Summary There is little information on the degree of concordance between the results obtained using the Chicago 3.0 (CCv3.0) and Chicago 4.0 (CCv4.0) protocols to interpret high-resolution manometry (HRM) seeking to determine the value provided by the new swallowing maneuvers included in the last protocol. This is a study of diagnostic tests, evaluating concordance by consistency between the results
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Effectiveness and safety of stag beetle knife (SB knife) in management of Zenker’s diverticulum: a systematic review and meta-analysis Dis. Esophagus (IF 2.6) Pub Date : 2023-12-15 Dushyant Singh Dahiya, Smit Deliwala, Saurabh Chandan, Daryl Ramai, Hassam Ali, Lena L Kassab, Antonio Facciorusso, Gursimran S Kochhar
Summary Stag Beetle Knife (SB Knife) is increasingly being utilized for Zenker’s Diverticulectomy (ZD). Our study assessed the effectiveness and safety of the SB Knife for the management of ZD. Ovid EBM reviews, Ovid Embase, Ovid Medline, ClinicalTrials.gov, Scopus, and Web of Science were searched to identify studies that utilized SB knife for ZD. Pooled proportions (PP) were calculated using the
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Management and outcomes in a consecutive series of patients with aero-digestive fistula at a tertiary gastro-esophageal surgery center Dis. Esophagus (IF 2.6) Pub Date : 2023-12-15 Fahad Murad, Fredrik Klevebro, Gert Henriksson, Ioannis Rouvelas, Mats Lindblad, Magnus Nilsson
Summary Aerodigestive fistula (ADF) is defined as a pathological connection between the upper digestive tract and the airway. ADF is associated with high morbidity and mortality and management is often complex. A cohort study including all patients admitted with ADF 2004–2022 at a single tertiary esophageal surgery center was performed based on prospectively collected administrative data and retrospectively
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Does prehabilitation before esophagectomy improve postoperative outcomes? A systematic review and meta-analysis Dis. Esophagus (IF 2.6) Pub Date : 2023-11-29 Kevin R An, Vanessa Seijas, Michael S Xu, Linda Grüßer, Sapna Humar, Amabelle A Moreno, Marvee Turk, Koushik Kasanagottu, Talal Alzghari, Arnaldo Dimagli, Michael A Ko, Jonathan Villena-Vargas, Stefania Papatheodorou, Mario F L Gaudino
Summary Esophagectomy for esophageal cancer is associated with high morbidity. It remains unclear whether prehabilitation, a strategy aimed at optimizing patients’ physical and mental functioning prior to surgery, improves postoperative outcomes. A systematic review and meta-analysis was conducted to evaluate the effect of prehabilitation on post-operative outcomes after esophagectomy. Data sources
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Sex- and gender-specific differences in symptoms and health-related quality of life among patients with gastroesophageal reflux disease Dis. Esophagus (IF 2.6) Pub Date : 2023-11-15 Kim Pelzner, Claudia Fuchs, Matti Petersen, Martin Maus, Christiane J Bruns, Jessica M Leers
Summary Gastroesophageal Reflux Disease (GERD) is a common chronic gastrointestinal disorder affecting both men and women. Nonerosive reflux disease generally affects more women, whereas GERD complications such as Barrett’s esophagus (BE) or esophageal cancer affect more men. The aim of this study was to evaluate sex- and gender-specific symptoms and health-related quality of life (HRQoL) among men
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Gastroesophageal reflux disease following laparoscopic vertical sleeve gastrectomy and laparoscopic roux-en-Y gastric bypass: meta-analysis and systematic review of 5-year data. Dis. Esophagus (IF 2.6) Pub Date : 2023-11-01 Muhammed A Memon,Emma Osland,Rossita M Yunus,Khorshed Alam,Zahirul Hoque,Shahjahan Khan
To compare 5-year gastroesophageal reflux outcomes following Laparoscopic Vertical Sleeve Gastrectomy (LVSG) and Laparoscopic Roux-en-Y gastric bypass (LRYGB) based on high quality randomized controlled trials (RCTs). We conducted a sub-analysis of our systematic review and meta-analysis of RCTs of primary LVSG and LRYGB procedures in adults for 5-year post-operative complications (PROSPERO CRD42018112054)
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Measurement and optimization of perioperative risk among patients undergoing surgery for esophageal cancer. Dis. Esophagus (IF 2.6) Pub Date : 2023-10-28 Jessie A Elliott,Emer Guinan,John V Reynolds
Esophagectomy is an exemplar of complex oncological surgery and is associated with a relatively high risk of major morbidity and mortality. In the modern era, where specific complications are targeted in prevention and treatment pathways, and where the principles of enhanced recovery after surgery are espoused, optimum outcomes are targeted via a number of approaches. These include comprehensive clinical
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Effect of intraoperative botulinum toxin injection on delayed gastric emptying and need for endoscopic pyloric intervention following esophagectomy: a systematic review, meta-analysis, and meta-regression analysis. Dis. Esophagus (IF 2.6) Pub Date : 2023-10-27 Shahab Hajibandeh,Shahin Hajibandeh,Matthew McKenna,William Jones,Paul Healy,Jolene Witherspoon,Guy Blackshaw,Wyn Lewis,Antonio Foliaki,Tarig Abdelrahman
The aim of this study was to evaluate the effect of intraoperative botulinum toxin (BT) injection on delayed gastric emptying (DGE) and need for endoscopic pyloric intervention (NEPI) following esophagectomy. In compliance with Preferred Reporting Items for Systematic reviews and Meta-Analyses statement standards, a systematic review of studies reporting the outcomes of intraoperative BT injection
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Is proton-pump inhibitor effective in preventing postoperative bleeding after esophageal endoscopic submucosal dissection? Dis. Esophagus (IF 2.6) Pub Date : 2023-10-09 Ippei Tanaka,Kunio Tarasawa,Hiroaki Saito,Dai Hirasawa,Kenji Fujimori,Kiyohide Fushimi,Tomoki Matsuda
Although proton-pump inhibitor (PPI) administration was reported to be effective in preventing delayed bleeding after gastric endoscopic submucosal dissection (ESD), its effectiveness in esophageal ESD is still unknown. We assessed whether PPI or vonoprazan administration was effective in preventing posterior hemorrhage after esophageal ESD. This retrospective cohort study used the Japanese Diagnosis
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Prevalence and severity of abdominal bloating in patients with gastroesophageal reflux disease. Dis. Esophagus (IF 2.6) Pub Date : 2023-09-19 Mark Shacker,Andrés R Latorre-Rodríguez,Sumeet K Mittal
Abdominal bloating (AB) is a common symptom among patients with gastroesophageal reflux disease (GERD); however, in clinical practice, its prevalence is likely underestimated due to the lack of objective tools to measure its frequency and severity. It is associated with dissatisfaction and worse quality of life, but data on its prevalence before and after mechanical control of GERD (i.e. fundoplication
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Evaluation of indocyanine green tracheobronchial fluorescence (ICG-TBF) via nebulization during minimally invasive esophagectomy. Dis. Esophagus (IF 2.6) Pub Date : 2023-09-12 Subramanyeshwar Rao Thammineedi,Sujit Chyau Patnaik,Syed Nusrath,Vibhavari Naik,Basanth Rayani,Pratap Reddy Ramalingam,Yogesh Vashist,Srijan Shukla
Surgical manipulation of the tracheobronchial complex is a contributing factor in pulmonary morbidity of esophagectomy. Accurate dissection between membranous trachea and bronchi with esophagus is essential. This study tests the feasibility of delivering indocyanine green (ICG) in an aerosol form to achieve tracheobronchial fluorescence (ICG-TBF). Patients with esophageal and esophagogastric junction
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The impact of thoracic duct resection on the long-term body composition of patients who underwent esophagectomy for esophageal cancer and survived without recurrence. Dis. Esophagus (IF 2.6) Pub Date : 2023-09-01 Erica Nishimura,Satoru Matsuda,Hirofumi Kawakubo,Jun Okui,Ryo Takemura,Masashi Takeuchi,Kazumasa Fukuda,Rieko Nakamura,Hiroya Takeuchi,Yuko Kitagawa
BACKGROUND We have reported the possible benefits of radical esophagectomy with thoracic duct (TD) resection in elective esophageal cancer surgery. However, the effect of TD resection on the long-term nutrition status remains unclear. METHODS Patients who underwent esophagectomy at Keio University between January 2006 and December 2018 were included, and those who had no recurrence for more than three
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Editorial: Role of thoracic duct ligation in esophagectomy. Dis. Esophagus (IF 2.6) Pub Date : 2023-09-01 C L Donohoe
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339. CYTOPLASMIC TRANSLOCATION OF BCLAF1 REGULATES SIX1 MRNA STABILITY THROUGH YTHDF2 TO PROMOTE AEROBIC GLYCOLYSIS IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA Dis. Esophagus (IF 2.6) Pub Date : 2023-08-31 Peipei Zhang, Weiguang Zhang, Junfei Jiang, Mingqiang Kang
Background Esophageal cancer is highly prevalent in China, with esophageal squamous cell carcinoma (ESCC) being the predominant pathological type. However, the unclear pathogenesis of ESCC presents a challenge for identifying effective targets for molecular targeted therapy. RNA methylation is an important epigenetic regulatory mechanism that may play a key role in carcinogenesis. Our research has
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447. PERIOPERATIVE OUTCOMES AFTER THORACOSCOPIC AND OPEN TRANSTHORACIC ESOPHAGECTOMY FOR CANCER Dis. Esophagus (IF 2.6) Pub Date : 2023-08-31 C S Pramesh, George Karimundackal, Sabita Jiwnani, Virendra Tiwari, Devayani Niyogi, Madhavi Shetmahajan, Priya Ranganathan, Swapnil Parab, Parveen Yadav, Pallavi Purwar, Apurva Ashok, Srinivas Gopinath, Rajesh Mistry
Background Surgery for esophageal cancer is complex and associated with considerable postoperative morbidity. Several strategies have been attempted to decrease morbidity after esophageal resection including enhanced recovery programmes, concentration of surgery in high-volume centres, and minimally invasive surgical approaches. Randomized trials showing superior perioperative outcomes with thoracoscopic
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318. THE INFLUENCE OF AGE IN OESOPHAGEAL CANCER TREATMENT DECISIONS: A MACHINE-LEARNING APPROACH Dis. Esophagus (IF 2.6) Pub Date : 2023-08-31 Nav Thavanesan, Arya Farahi, Zoe Walters, Timothy Underwood, Ganesh Vigneswaran
Background Although patient age plays a crucial role in determining curative treatment options for Oesophageal cancer (OC), the exact extent of its influence is not well defined. We used a computational machine learning (ML) approach to model the impact of age in combination with other key decision drivers, such as tumour and patient characteristics, on the likelihood of receiving different types of
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465. COMPLETE RESPONSE IN BARRETT’S HIGH-GRADE DYSPLASIA WITH THE UTILISATION OF RADIOFREQUENCY ABLATION: A SYSTEMATIC REVIEW Dis. Esophagus (IF 2.6) Pub Date : 2023-08-31 Pooja Prasad, Joshua Brown, Hannah Sellars, Alexander Phillips
Background Radiofrequency ablation (RFA) is increasingly utilised as part of the endoscopic treatment of Barrett’s esophagus (BE) with high-grade dysplasia as a recognised alternative to surgical resection. The aim of this review is to summarise the current evidence on the utility of RFA in achieving complete clearance of HGD within BE and any resultant treatment complications with this endoscopic
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203. SURVIVAL IMPACT OF THORACIC DUCT RESECTION IN PATHOLOGICAL RESPONDERS AFTER TRIPLET CHEMOTHERAPY: EXPLORATORY ANALYSIS FROM MULTICENTER PHASE III TRIAL JCOG1109 Dis. Esophagus (IF 2.6) Pub Date : 2023-08-31 Satoru Matsuda, Hiroya Takeuchi, Ken Kato, Ryunosuke Machida, Yasuhiro Tsubosa, Hiroyuki Daiko, Soji Ozawa, Takashi Ogata, Takashi Fukuda, Takeo Fujita, Tetsuya Abe, Takeo Bamba, Masayuki Watanabe, Hirofumi Kawakubo, Yuichi Shibuya, Dai Otsubo, Tomokazu Kakishita, Naoyoshi Hashimoto, Keita Sasaki, Yuko Kitagawa
Purpose JCOG1109 was a three-arm randomized phase III trial to confirm the survival advantage of docetaxel plus cisplatin plus 5-fluorouracil (DCF) and cisplatin plus 5-fluorouracil (CF) combined with radiotherapy (CF-RT) over CF as preoperative treatment for locally advanced esophageal squamous cell carcinoma. The purpose of this study was to evaluate the survival impact of thoracic duct (TD) resection
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254. THE IMPACT OF D2 VERSUS D1 LYMPHADENECTOMY IN SIEWERT II GASTROESOPHAGEAL JUNCTION (GEJ) CANCER Dis. Esophagus (IF 2.6) Pub Date : 2023-08-31 Nathan Alcasid, Kian Banks, Deanna Fink, Cynthia Susai, Katherine Barnes, Rachel Wile, Angela Sun, Ashish Patel, Simon Ashiku, Jeffrey Velotta
Background Though a myriad of multimodal treatment options exist for gastroesophageal junction (GEJ) cancer, surgical resection remains the mainstay for potential cure. Extended nodal dissection with a D2 lymphadenectomy (LAD) beyond the D1 peri-gastric dissection remains controversial for Siewert II GEJ cancer. Though D2 LAD may lead to increased lymph node harvest, its effect on overall survival
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261. THE PROGNOSTIC IMPACT OF PRE-OPERATIVE NUTRITIONAL INDICATORS OF THE PATIENTS WITH ESOPHAGEAL CANCER Dis. Esophagus (IF 2.6) Pub Date : 2023-08-31 Chia-Cheng Kao, Ke-Cheng Chen, Pei-Ming Huang, Mong-Wei Lin, Shuenn-Wen Kuo, Chia-Hsien Cheng, Feng-Ming Hsu, Ta-Chen Huang, Hsao-Hsun Hsu, Jang-Ming Lee
Background Esophagectomy with or without concurrent chemoradiotherapy had been the treatment of choice for the patients with clinically operable esophageal cancer. In addition to the standard TNM status of the disease, it is unknown about whether pre-operative nutrition indicators, inclusive of hemoglobin value and albumin level before treatment, will have impact on post-operative survival outcome
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450. LINEAR STAPLED TECHNIQUE FOR ROBOTIC ASSISTED MINIMALLY INVASIVE ESOPHAGECTOMY AND GASTRECTOMY: TECHNIQUE, STEPWISE INTRODUCTION, REPRODUCIBILITY AND OUTCOMES Dis. Esophagus (IF 2.6) Pub Date : 2023-08-31 Alexander Bull, Nima Abbassi, Pritam Singh, Anantha Madhavan, Arul Immanuel, Shaun Preston
Background Robotic-assisted surgery (RAS) for esophagectomy and gastrectomy is gaining in popularity. Compared to open oesophagectomy and conventional minimally invasive techniques, RAS is associated with decreased rates of complications, increased harvested lymph nodes and shorter length-of-stay. However, high anastomotic leak rates (20–27%) have been seen within randomised trials and case series
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333. HIGH CERVICAL ANASTOMOSIS USING NARROW GASTRIC TUBE CAN REDUCE LEAKAGE AFTER MCKEOWN ESOPHAGECTOMY Dis. Esophagus (IF 2.6) Pub Date : 2023-08-31 Xufeng Guo
Background Anastomotic leakage is one of the most serious complications after esophagectomy. High cervical anastomosis with narrow gastric tube has the potential to reduce the leakage after McKeown esophagectomy. Methods A total of 533 patients who received McKeown radical resection for esophageal cancer in Shanghai Chest Hospital from March 2018 to March 2023 were included in this study, including
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375. RURAL PATIENTS HAVE A PROLONGED INPATIENT RECOVERY PROCESS AFTER ESOPHAGECTOMY COMPARED TO NON-RURAL PATIENTS AT A HIGH-VOLUME ESOPHAGEAL PROGRAM Dis. Esophagus (IF 2.6) Pub Date : 2023-08-31 Julia Schroeder, Kiran Lagisetty, William Lynch, Jules Lin, Andrew Chang, Mark Orringer, Rishindra Reddy
Background Geographic access to care plays a large role in health disparities in esophageal cancer care, with rural individuals often travelling further to access complex healthcare services. We sought to characterize peri-operative outcomes in patients undergoing esophagectomy for loco-regional cancer at a single academic tertiary care center based on geographic home location. We hypothesize that
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312. H ANASTOMOSIS IN MECKOWN ESOPHAGECTOMY FOR THE REDUCED ANASTOMOTIC LEAKAGE, OBSTRUCTION, AND GASTROESOPHAGEAL REFLUX Dis. Esophagus (IF 2.6) Pub Date : 2023-08-31 Na Wu, Qi Xia, Yang Hu
Background Anastomotic Leakage, obstruction, and gastroesophageal reflux are the major conditions to be taken into account during restoration of alimentary transit in Meckown esophagectomy. There are numerous types of anastomosis techniques to achieve different emphases while the optimal one has not been established. The outcomes of the novel H anastomosis and the conventional end to end layered anastomosis
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164. INTRAOPERATIVE LYMPHATIC FLOW MAPPING USING INDOCYANINE GREEN PREDICTS LYMPH NODE METASTASIS IN ESOPHAGEAL CANCER PATIENTS NOT TREATED WITH NEOADJUVANT CHEMOTHERAPY Dis. Esophagus (IF 2.6) Pub Date : 2023-08-31 Shinichiro Shiomi
Background Lymphatic flow mapping using near-infrared fluorescence (NIR) imaging with indocyanine green (ICG) has been used for the intraoperative prediction of lymph node metastasis (LNM) in various cancers. Previous studies examined the feasibility of applying this technique to patients with esophageal cancer. However, a consistent method that yields sufficient diagnostic quality has yet to be confirmed
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423. DYSPHAGIA AND RE-INTERVENTION AFTER MYOTOMY FOR ACHALASIA: A MATTER OF TECHNIQUE, OR A MATTER OF TIME? Dis. Esophagus (IF 2.6) Pub Date : 2023-08-31 Ryan Campagna, Kian Pourak, Piroz Bahar, Eugene Oh, Kiran Lagisetty, Mark Orringer, Jules Lin, Andrew Chang, Rishindra Reddy
Background Achalasia is an incurable neurodegenerative disease of the esophagus. Palliative treatment includes disruption of the lower esophageal sphincter via multiple techniques, including open Heller myotomy (OHM), laparoscopic Heller myotomy (LHM), and per-oral esophageal myotomy (POEM). There is a paucity of data comparing long-term outcomes between OHM, LHM, and POEM. We sought to evaluate the
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430. MAPPING OF LYMPH NODE METASTASIS FROM ESCC AFTER NEOADJUVANT TREATMENT: A PROSPECTIVE ANALYSIS FROM A HIGH-VOLUME INSTITUTION IN CHINA Dis. Esophagus (IF 2.6) Pub Date : 2023-08-31 Hanlu Zhang, Long-Qi Chen, Yun Wang
Objective The aim of the study was to describe the prevalence of lymph node metastases per lymph node station for esophageal squamous cell carcinoma (ESCC) after neoadjuvant treatment. Methods Clinicopathological variables of ESCC patients were retrieved from the prospective database of the Surgical Esophageal Cancer Patient Registry in West China Hospital, Sichuan University. Two-field lymphadenectomy
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201. PREOPERATIVE HANDGRIP STRENGTH IS ASSOCIATED WITH POSTOPERATIVE PULMONARY COMPLICATIONS AFTER MAJOR ABDOMINAL SURGERY: A PROSPECTIVE MULTICENTRE INTERNATIONAL COHORT STUDY Dis. Esophagus (IF 2.6) Pub Date : 2023-08-31 Renishka Sellayah, Ianthe Boden
Background Low muscle strength is a primary indicator of sarcopenia, defined by the European Working Group on Sarcopenia (EWGSOP2) and is related to postoperative complications after major surgery. Handgrip strength is easily measured preoperatively and is an alternative to skeletal muscle index assessments, which are time consuming and require specialised equipment. The current studies pertaining
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478. ROBOTIC REPAIR OF EPIPHRENIC DIVERTICULUM Dis. Esophagus (IF 2.6) Pub Date : 2023-08-31 Edno Tales Bianchi, Sergio Szachnowicz, Alexandra Cirlinas, Rubens Sallum
We show a robotic repair of a epiphrenic diverticulum in a patient with a previous treatment 10 years ago by laparoscopic with diverticulectomy with a heller miotomy. This time we performed a complete ressection with a new miotomy in a thoracic aproach https://drive.google.com/file/d/1ancYQoy9csA1NjXhswGuDtkd1EjR0M7B/view?usp = sharing.
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248. SYSTEMIC INFLAMMATORY MARKERS AS PROGNOSTIC FACTORS IN ESOPHAGEAL CANCER: A MEXICAN PERSPECTIVE Dis. Esophagus (IF 2.6) Pub Date : 2023-08-31 Alberto Mitsuo Leon Takahashi, Horacio Noe Lopez Basave, Daniel Jones, Leonardo Saul Lino-Silva, Rosa Angelica Salcedo-Hernandez, German Calderillo-Ruiz, Maria Del Consuelo Diaz-Romero, Maria Fernanda Gomez-Hernandez, Angel Herrera Gomez
Background Esophageal cancer (EC) represents the eighth most commonly diagnosed cancer, and sixth cause of cancer-related deaths worldwide. Several studies have demonstrated an association between systemic inflammation, anti-cancer immunity, and poor oncological outcomes in patients with EC. Biomarkers including neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte
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309. SURGICAL TREATMENT FOR THE RECURRENT SITE OF ESOPHAGEAL CANCER AFTER ESOPHAGECTOMY Dis. Esophagus (IF 2.6) Pub Date : 2023-08-31 Hiroshi Okamoto, Yusuke Taniyama, Chiaki Sato, Yohei Ozawa, Hirotaka Ishida, Ken Koseki, Yuto Muranami, Takashi Kamei
Background Although the outcome of patients with recurrent esophageal cancer following radical esophagectomy is extremely poor, long-term survival can be achieved with multimodal therapy, including surgical resection of the recurrent lesion. Developing a treatment strategy is a critical issue; therefore, we examined the indications and optimal timing for surgical treatment in patients with recurrence
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286. A BIBLIOMETRIC ANALYSIS OF NEOADJUVANT THERAPY FOR ESOPHAGEAL CANCER Dis. Esophagus (IF 2.6) Pub Date : 2023-08-31 Yizhou Huang, Bin Zheng, Maohui Chen, Shuliang Zhang, Taidui Zeng, Chun Chen
Background The study aims to summarize publication characteristics of neoadjuvant therapy for esophageal cancer and create scientific maps to explore hotspots and emerging trends with bibliometric methods. Method The publications between 2013 and 2022 were retrieved from the Web of Science Core Collection (WoSCC) on March 4, 2023. Bibliometric tools including VOSviewer and CiteSpace were used for statistical
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453. TREATMENT AND SURVIVAL OF PATIENTS WITH A POSITIVE RESECTION MARGIN AFTER NEOADJUVANT CHEMORADIOTHERAPY AND ESOPHAGECTOMY Dis. Esophagus (IF 2.6) Pub Date : 2023-08-31 Charlène Zijden, Pieter Sluis, Bianca Mostert, Joost Nuyttens, Manon Spaander, Roelf Valkema, Jelle Ruurda, Bas Wijnhoven, Sjoerd Lagarde
Background Esophagectomy after neoadjuvant chemoradiotherapy (nCRT) is associated with a tumor-positive resection margin in 4–9% of patients. Although survival in patients with a positive margin is decreased, Western guidelines do not recommend adjuvant systemic/local treatment after esophagectomy. The aim of this study was to assess whether patients underwent adjuvant therapy, regardless the lack
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457. WHEN LAPAROSCOPIC MYOTOMY FAILS, COMPLEMENTARY PNEUMATIC DILATIONS REPRESENT AN EFFECTIVE AND SAFE OPTION Dis. Esophagus (IF 2.6) Pub Date : 2023-08-31 Andrea Costantini, Renato Salvador, Luca Provenzano, Giovanni Capovilla, Loredana Nicoletti, Francesca Forattini, Arianna Vittori, Giulia Nezi, Michele Valmasoni, Mario Costantini
Background In the last 3 decades, laparoscopic Heller myotomy (LHM) has represented the treatment of choice for esophageal achalasia (EA), solving symptoms in most patients. Little is known about the fate of patients who relapsed after LHM, or about their most appropriate treatment. In this study we aimed at evaluating the results of complementary pneumatic dilations (CPD) after ineffective LHM. Methods
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205. LONGITUDINAL PATIENT-REPORTED OUTCOMES AFTER MINIMALLY INVASIVE MCKEOWN ESOPHAGECTOMY IN PATIENTS WITH ESOPHAGEAL SQUAMOUS CELL CARCINOMA Dis. Esophagus (IF 2.6) Pub Date : 2023-08-31 Xin Nie, Yan Miao, Wenwu He, Changding Li, Zhiyu Li, Yongtao Han, Chenghao Wang
Background Surgery for esophageal squamous cell carcinoma (ESCC) is characterized by a poor prognosis and high complication rate, resulting in a heavy symptom burden and poor quality of life (QOL). Neoadjuvant therapy followed by surgery improved the postoperative survival of ESCC patients. This study was a longitudinal patient-reported outcomes (PROs) evaluation to compare the effects of neoadjuvant
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359. NFE2L2 MUTATIONS ARE PREDICTIVE AND PROGNOSTIC OF TREATMENT OUTCOME IN RESECTABLE ESOPHAGEAL SQUAMOUS CELL CARCINOMA PATIENTS Dis. Esophagus (IF 2.6) Pub Date : 2023-08-31 Josephine Ko, Chen Guo, Anthony Wing-Ip Lo, Lihua Tao, Simon Law, Ka-On Lam, Dora Lai-Wan Kwong, Ian Yu-Hong Wong, Claudia Lai-Yin Wong, Siu-Yin Chan, Kwan-Kit Chan, Tsz-Ting Law, Alvin Ka-Kiu Leung, Carissa Wing-Yan Wong, Wei Dai, Maria Li Lung
Background The poor prognosis of resectable esophageal squamous cell carcinoma (ESCC) poses an unmet need to identify genomic early predictive and prognostic biomarkers to improve treatment outcome and risk stratification. Methods Retrospective targeted sequencing was performed on 80 ESCC formalin-fixed, paraffin-embedded (FFPE) tumor specimens from 37 good responders and 43 poor responders receiving
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267. IDENTIFYING CANCER-ASSOCIATED FIBROBLAST POPULATIONS DRIVING THERAPY RESISTANCE IN GASTROESOPHAGEAL ADENOCARCINOMA Dis. Esophagus (IF 2.6) Pub Date : 2023-08-31 Kulsum Tai, Michael Strasser, Sanjima Pal, Julie Bérubé, Wotan Zeng, Iris Kong, Adam Hoffman, James Tankel, Nicholas Bertos, Veena Sangwan, Sui Huang, Lorenzo Ferri
Background Peri-operative docetaxel-based triplet chemotherapy is the standard-of-care treatment for advanced gastroesophageal adenocarcinoma (GEA). However, most patients recur due to innate or acquired resistance. Although distinct populations of cancer-associated fibroblasts (CAFs) within the tumor microenvironment play important roles in conferring chemoresistance in other cancer types, this paradigm
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190. PROGNOSTIC VALUE OF COMBINATION OF LYMPHOCYTE-TO-MONOCYTE-RATIO AND CYFRA 21-1 IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA Dis. Esophagus (IF 2.6) Pub Date : 2023-08-31 Yuxin Yang, Zhichao Liu, Chao Jiang, Jie Pan, Boyao Yu, Kaiyuan Zhu, Zhigang Li
Background Previous studies have shown that serum tumor markers and systematic inflammatory and nutritional indicators, including Cytokeratin fragments (CYFRA) 21–1 and the lymphocyte-to-monocyte ratio (LMR), are associated with the prognosis of esophageal malignancies. However, their individual prognostic sensitivity and specificity are not yet sufficient. This study aims to investigate the potential
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330. PRE-EMPTIVE ENDOLUMINAL VACUUM THERAPY WITH A SURGICAL DRAIN FOR REDUCTION OF ANASTOMOTIC LEAK RATE FOLLOWING MINIMALLY INVASIVE ESOPHAGECTOMY Dis. Esophagus (IF 2.6) Pub Date : 2023-08-31 Sri Sivarajan, Suheelan Kulasegaran, Nicholas Penney, Kaso Ari, Bhaskar Kumar, Loveena Sreedharan
Background Endoluminal vacuum therapy (EVT) is an effective treatment for anastomotic leak (AL) following esophagectomy. A novel application of EVT is to utilise its effect to improve microcirculation and granulation at the anastomosis pre-emptively to reduce the risk of AL. We describe a unique method of positioning a fenestrated surgical drain with applied vacuum suction at the level of the anastomosis