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Proton pump inhibitors increase the risk of carbapenem-resistant Enterobacteriaceae colonization by facilitating the transfer of antibiotic resistance genes among bacteria in the gut microbiome Gut Microbes (IF 12.2) Pub Date : 2024-04-18 Imchang Lee, Jae-Won Jo, Heung-Jeong Woo, Ki Tae Suk, Seung Soon Lee, Bong-Soo Kim
Carbapenem-resistant Enterobacteriaceae (CRE) pose a global health threat; however, there is still limited understanding of the risk factors and underlying mechanisms of CRE colonization in the gut...
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The gut microbe pair of Oribacterium sp. GMB0313 and Ruminococcus sp. GMB0270 confers complete protection against SARS-CoV-2 infection by activating CD8+ T cell-mediated immunity Gut Microbes (IF 12.2) Pub Date : 2024-04-18 Mingda Wang, Enkhchimeg Lkhagva, Sura Kim, Chongkai Zhai, Md Minarul Islam, Hyeon J. Kim, Seong-Tshool Hong
Despite the potential protective role of the gut microbiome against COVID-19, specific microbes conferring resistance to COVID-19 have not yet been identified. In this work, we aimed to identify an...
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Sialic acid-based probiotic intervention in lactating mothers improves the neonatal gut microbiota and immune responses by regulating sialylated milk oligosaccharide synthesis via the gut–breast axis Gut Microbes (IF 12.2) Pub Date : 2024-04-17 Yushuang Wang, Binqi Rui, Xiaolei Ze, Yujia Liu, Da Yu, Yinhui Liu, Zhi Li, Yu Xi, Xixi Ning, Zengjie Lei, Jieli Yuan, Liang Li, Xuguang Zhang, Wenzhe Li, Yanjie Deng, Jingyu Yan, Ming Li
Human milk oligosaccharides (HMOs) are vital milk carbohydrates that help promote the microbiota-dependent growth and immunity of infants. Sialic acid (SA) is a crucial component of sialylated milk...
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A randomized double-blind, placebo-controlled trial to evaluate the safety and efficacy of live Bifidobacterium longum CECT 7347 (ES1) and heat-treated Bifidobacterium longum CECT 7347 (HT-ES1) in participants with diarrhea-predominant irritable bowel syndrome Gut Microbes (IF 12.2) Pub Date : 2024-04-17 S Srivastava, U Basak, M Naghibi, V Vijayakumar, R Parihar, J Patel, PS Jadon, A Pandit, RR Dargad, S Khanna, S Kumar, R Day
To determine the efficacy of the probiotic Bifidobacterium longum CECT 7347 (ES1) and postbiotic heat-treated Bifidobacterium longum CECT 7347 (HT-ES1) in improving symptom severity in adults with ...
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Effects of Prevotella copri on insulin, gut microbiota and bile acids Gut Microbes (IF 12.2) Pub Date : 2024-04-16 Jiatai Gong, Qianjin Zhang, Ruizhi Hu, Xizi Yang, Chengkun Fang, Liping Yao, Jing Lv, Long Wang, Mingkun Shi, Wentao Zhang, Siqi Ma, Hongkun Xiang, Hongfu Zhang, De-Xing Hou, Yulong Yin, Jianhua He, Lijun Peng, Shusong Wu
Obesity is becoming a major global health problem in children that can cause diseases such as type 2 diabetes and metabolic disorders, which are closely related to the gut microbiota. However, the ...
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Dietary fiber guar gum-induced shift in gut microbiota metabolism and intestinal immune activity enhances susceptibility to colonic inflammation Gut Microbes (IF 12.2) Pub Date : 2024-04-17 Devendra Paudel, Divek V. T. Nair, Sangshan Tian, Fuhua Hao, Umesh K. Goand, Grace Joseph, Eleni Prodes, Zhi Chai, Chloé E.M. Robert, Benoit Chassaing, Andrew D. Patterson, Vishal Singh
With an increasing interest in dietary fibers (DFs) to promote intestinal health and the growth of beneficial gut bacteria, there is a continued rise in the incorporation of refined DFs in processe...
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A high fiber diet or supplementation with Lactococcus lactis subspecies cremoris to pregnant mice confers protection against intestinal injury in adult offspring Gut Microbes (IF 12.2) Pub Date : 2024-04-15 Maria E. Barbian, Joshua A. Owens, Crystal R. Naudin, Patricia Denning, Ravi M. Patel, Rheinallt M. Jones
The diet during pregnancy, or antenatal diet, influences the offspring’s intestinal health. We previously showed that antenatal butyrate supplementation reduces injury in adult murine offspring wit...
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Cognitive behavioral and mindfulness with daily exercise intervention is associated with changes in intestinal microbial taxa and systemic inflammation in patients with Crohn’s disease Gut Microbes (IF 12.2) Pub Date : 2024-04-09 Ilan K, Motro Y, Nemirovsky A, Schwartz D, Goren G, Sergienko R, Greenberg D, Slonim-Nevo V, Sarid O, Friger M, Regev S, Odes S, Moran-Gilad J, Monsonego A
Crohn’s disease (CD) is a chronic inflammatory bowel disease associated with psychological distress and intestinal microbial changes. Here, we examined whether a 3-month period of Cognitive Behavio...
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New treatment approaches for Clostridioides difficile infections: alternatives to antibiotics and fecal microbiota transplantation Gut Microbes (IF 12.2) Pub Date : 2024-04-09 Tomaž Bratkovič, Abida Zahirović, Maruša Bizjak, Maja Rupnik, Borut Štrukelj, Aleš Berlec
Clostridioides difficile causes a range of debilitating intestinal symptoms that may be fatal. It is particularly problematic as a hospital-acquired infection, causing significant costs to the heal...
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Multi-strain probiotics during pregnancy in women with obesity influence infant gut microbiome development: results from a randomized, double-blind placebo-controlled study Gut Microbes (IF 12.2) Pub Date : 2024-04-09 Sofie Ingdam Halkjær, Malene Refslund Danielsen, Victoria E. de Knegt, Lee O’Brien Andersen, Christen Rune Stensvold, Henrik Vedel Nielsen, Hengameh Chloé Mirsepasi-Lauridsen, Karen Angeliki Krogfelt, Dina Cortes, Andreas Munk Petersen
Probiotics have been described to influence host health and prevent the risk of obesity by gut microbiome (GM) modulation. In a randomized double-blinded placebo-controlled feasibility study, we in...
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Pathogen-specific alterations in intestinal microbiota precede urinary tract infections in preterm infants: a longitudinal case-control study Gut Microbes (IF 12.2) Pub Date : 2024-04-01 Luyang Hong, Yihuang Huang, Junyan Han, Shujuan Li, Lan Zhang, Qi Zhou, Xincheng Cao, Weiyin Yu, Xinhui Guo, Yi Yang, Yufeng Zhou, Weili Yan, Shangyu Hong, Siyuan Jiang, Yun Cao
Urinary tract infections (UTIs) are among the most common late-onset infections in preterm infants, characterized by nonspecific symptoms and a pathogenic spectrum that diverges from that of term i...
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Gastrointestinal microbiota and metabolites possibly contribute to distinct pathogenicity of SARS-CoV-2 proto or its variants in rhesus monkeys Gut Microbes (IF 12.2) Pub Date : 2024-04-02 Hongyu Chen, Junbin Wang, Kaiyun Ding, Jingwen Xu, Yun Yang, Cong Tang, Yanan Zhou, Wenhai Yu, Haixuan Wang, Qing Huang, Bai Li, Dexuan Kuang, Daoju Wu, Zhiwu Luo, Jiahong Gao, Yuan Zhao, Jiansheng Liu, Xiaozhong Peng, Shuaiyao Lu, Hongqi Liu
Gastrointestinal (GI) infection is evidenced with involvement in COVID-19 pathogenesis caused by SARS-CoV-2. However, the correlation between GI microbiota and the distinct pathogenicity of SARS-Co...
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Integrative analysis with microbial modelling and machine learning uncovers potential alleviators for ulcerative colitis Gut Microbes (IF 12.2) Pub Date : 2024-04-02 Jinlin Zhu, Jialin Yin, Jing Chen, Mingyi Hu, Wenwei Lu, Hongchao Wang, Hao Zhang, Wei Chen
Ulcerative colitis (UC) is a challenging form of inflammatory bowel disease, and its etiology is intricately linked to disturbances in the gut microbiome. To identify the potential alleviators of U...
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The effects of antibiotic exposures on the gut resistome during hematopoietic cell transplantation in children Gut Microbes (IF 12.2) Pub Date : 2024-03-30 Sarah M. Heston, Rebecca R. Young, Kirsten Jenkins, Paul L. Martin, Andre Stokhuyzen, Doyle V. Ward, Shakti K. Bhattarai, Vanni Bucci, Mehreen Arshad, Nelson J. Chao, Patrick C. Seed, Matthew S. Kelly
Antibiotic resistance is a global threat driven primarily by antibiotic use. We evaluated the effects of antibiotic exposures on the gut microbiomes and resistomes of children at high risk of colon...
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Integrated analysis of gut metabolome, microbiome, and brain function reveal the role of gut-brain axis in longevity Gut Microbes (IF 12.2) Pub Date : 2024-03-28 Bin Jiao, Ziyu Ouyang, Qianqian Liu, Tianyan Xu, Meidan Wan, Guangrong Ma, Lu Zhou, Jifeng Guo, Junling Wang, Beisha Tang, Zhixiang Zhao, Lu Shen
The role of microbiota-gut-brain axis in modulating longevity remains undetermined. Here, we performed a multiomics analysis of gut metagenomics, gut metabolomics, and brain functional near-infrare...
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Gastrointestinal signals in supplemented media reveal a role in adherence for the Shigella flexneri sap autotransporter gene Gut Microbes (IF 12.2) Pub Date : 2024-03-28 Yrvin León, Raphael Honigsberg, David A. Rasko, Christina S. Faherty
Shigella flexneri causes severe diarrheal disease worldwide. While many aspects of pathogenesis have been elucidated, significant knowledge gaps remain regarding the role of putative chromosomally-...
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From animal models to gut-on-chip: the challenging journey to capture inter-individual variability in chronic digestive disorders Gut Microbes (IF 12.2) Pub Date : 2024-03-27 Aicha Kriaa, Vincent Mariaule, Charlotte De Rudder, Amin Jablaoui, Harry Sokol, Paul Wilmes, Emmanuelle Maguin, Moez Rhimi
Chronic digestive disorders are of increasing incidence worldwide with expensive treatments and no available cure. Available therapeutic schemes mainly rely on symptom relief, with large degrees of...
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Oral pathobiont Klebsiella chaperon usher pili provide site-specific adaptation for the inflamed gut mucosa Gut Microbes (IF 12.2) Pub Date : 2024-03-28 Yijie Guo, Sho Kitamoto, Gustavo Caballero-Flores, Yeji Kim, Daisuke Watanabe, Kohei Sugihara, Gabriel Núñez, Christopher J. Alteri, Naohiro Inohara, Nobuhiko Kamada
The ectopic gut colonization by orally derived pathobionts has been implicated in the pathogenesis of various gastrointestinal diseases, including inflammatory bowel disease (IBD). For example, gut...
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Transplant of microbiota from Crohn’s disease patients to germ-free mice results in colitis Gut Microbes (IF 12.2) Pub Date : 2024-03-27 Irshad Ali Sheikh, Jared Bianchi-Smak, Daniel Laubitz, Gabriele Schiro, Monica T. Midura-Kiela, David G. Besselsen, Gayatri Vedantam, Sara Jarmakiewicz, Rafał Filip, Fayez K. Ghishan, Nan Gao, Pawel R. Kiela
Although the role of the intestinal microbiota in the pathogenesis of inflammatory bowel disease (IBD) is beyond debate, attempts to verify the causative role of IBD-associated dysbiosis have been ...
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Intestinal microbiota modulates neuroinflammatory response and brain injury after neonatal hypoxia-ischemia Gut Microbes (IF 12.2) Pub Date : 2024-03-27 Alexander Drobyshevsky, Sylvia Synowiec, Ivan Goussakov, Rafael Fabres, Jing Lu, Michael Caplan
Premature infants lack a normal intestinal microbial community and also at risk of perinatal hypoxic-ischemic (HI) brain injury, which is considered to be one of the major factors for motor, sensor...
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Fusobacterium nucleatum induces chemoresistance in colorectal cancer by inhibiting pyroptosis via the Hippo pathway Gut Microbes (IF 12.2) Pub Date : 2024-03-27 Ni Wang, Lu Zhang, Xiao-Xu Leng, Yi-Le Xie, Zi-Ran Kang, Li-Cong Zhao, Lin-Hong Song, Cheng-Bei Zhou, Jing-Yuan Fang
Chemotherapy resistance is one of the main reasons for the poor prognosis of colorectal cancer (CRC). Moreover, dysbiosis of gut bacteria was found to be a specific environmental risk factor. In th...
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Indole-3-acetic acid alleviates DSS-induced colitis by promoting the production of R-equol from Bifidobacterium pseudolongum Gut Microbes (IF 12.2) Pub Date : 2024-03-25 Miaomiao Li, Xue Han, Lijun Sun, Xinjuan Liu, Weizhen Zhang, Jianyu Hao
Inflammatory bowel disease (IBD) is characterized by immune-mediated, chronic inflammation of the intestinal tract. The occurrence of IBD is driven by the complex interactions of multiple factors. ...
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Breaking the barriers: the role of gut homeostasis in Metabolic-Associated Steatotic Liver Disease (MASLD) Gut Microbes (IF 12.2) Pub Date : 2024-03-21 Raquel Benedé-Ubieto, Francisco Javier Cubero, Yulia A. Nevzorova
Obesity, insulin resistance (IR), and the gut microbiome intricately interplay in Metabolic-associated Steatotic Liver Disease (MASLD), previously known as Non-Alcoholic Fatty Liver Disease (NAFLD)...
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mNFE: microbiome network flow entropy for detecting pre-disease states of type 1 diabetes Gut Microbes (IF 12.2) Pub Date : 2024-03-21 Rong Gao, Peiluan Li, Yueqiong Ni, Xueqing Peng, Jing Ren, Luonan Chen
In the development of Type 1 diabetes (T1D), there are critical states just before drastic changes, and identifying these pre-disease states may predict T1D or provide crucial early-warning signals...
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Using a human colonoid-derived monolayer to study bacteriophage translocation Gut Microbes (IF 12.2) Pub Date : 2024-03-22 Huu Thanh Le, Alicia Fajardo Lubian, Bethany Bowring, David van der Poorten, Jonathan Iredell, Jacob George, Carola Venturini, Golo Ahlenstiel, Scott Read
Bacteriophages (phages) are estimated to be the most abundant microorganisms on Earth. Their presence in human blood suggests that they can translocate from non-sterile sites such as the gastrointe...
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CobB-mediated deacetylation of the chaperone CesA regulates Escherichia coli O157:H7 virulence Gut Microbes (IF 12.2) Pub Date : 2024-03-19 Linxing Li, Bin Yang, Jing Wang, Yi Wei, Binbin Xiang, Yutao Liu, Pan Wu, Wanwu Li, Yanling Wang, Xinyu Zhao, Jingliang Qin, Miaomiao Liu, Ruiying Liu, Guozhen Ma, Tian Fu, Min Wang, Bin Liu
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a common food-borne pathogen that can cause acute diseases. Lysine acetylation is a post-translational modification (PTM) that occurs in various...
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BaiJ and BaiB are key enzymes in the chenodeoxycholic acid 7α-dehydroxylation pathway in the gut microbe Clostridium scindens ATCC 35704 Gut Microbes (IF 12.2) Pub Date : 2024-03-11 Karin Lederballe Meibom, Solenne Marion, Colin Volet, Théo Nass, Eduard Vico-Oton, Laure Menin, Rizlan Bernier-Latmani
Bile acid transformation is a common gut microbiome activity that produces secondary bile acids, some of which are important for human health. One such process, 7α-dehydroxylation, converts the pri...
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Stress in the microbiome-immune crosstalk Gut Microbes (IF 12.2) Pub Date : 2024-03-15 Eléonore Beurel
The gut microbiota exerts a mutualistic interaction with the host in a fragile ecosystem and the host intestinal, neural, and immune cells. Perturbations of the gastrointestinal track composition a...
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Long- and short-term effects of fecal microbiota transplantation on antibiotic resistance genes: results from a randomized placebo-controlled trial Gut Microbes (IF 12.2) Pub Date : 2024-03-13 Armin Rashidi, Maryam Ebadi, Tauseef Ur Rehman, Heba Elhusseini, David Kazadi, Hossam Halaweish, Mohammad H. Khan, Andrea Hoeschen, Qing Cao, Xianghua Luo, Amanda J. Kabage, Sharon Lopez, Shernan G. Holtan, Daniel J. Weisdorf, Chang Liu, Satoshi Ishii, Alexander Khoruts, Christopher Staley
In small series, third-party fecal microbiota transplantation (FMT) has been successful in decolonizing the gut from clinically relevant antibiotic resistance genes (ARGs). Less is known about the ...
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ZntA maintains zinc and cadmium homeostasis and promotes oxidative stress resistance and virulence in Vibrio parahaemolyticus Gut Microbes (IF 12.2) Pub Date : 2024-03-11 Chengkun Zheng, Yimeng Zhai, Jun Qiu, Mengxian Wang, Zhengzhong Xu, Xiang Chen, Xiaohui Zhou, Xinan Jiao
Although metals are essential for life, they are toxic to bacteria in excessive amounts. Therefore, the maintenance of metal homeostasis is critical for bacterial physiology and pathogenesis. Vibri...
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Modulation of chronic obstructive pulmonary disease progression by antioxidant metabolites from Pediococcus pentosaceus: enhancing gut probiotics abundance and the tryptophan-melatonin pathway Gut Microbes (IF 12.2) Pub Date : 2024-03-06 Yiting Liu, Longjie Li, Jing Feng, Bing Wan, Qiang Tu, Wei Cai, Fa Jin, Guiying Tang, Lígia R. Rodrigues, Xiuwei Zhang, Jia Yin, Yunlei Zhang
Chronic obstructive pulmonary disease (COPD), a condition primarily linked to oxidative stress, poses significant health burdens worldwide. Recent evidence has shed light on the association between...
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A modified Mediterranean-style diet enhances brain function via specific gut-microbiome-brain mechanisms Gut Microbes (IF 12.2) Pub Date : 2024-03-06 Gwoncheol Park, Saurabh Kadyan, Nathaniel Hochuli, Julie Pollak, Bo Wang, Gloria Salazar, Paramita Chakrabarty, Philip Efron, Julia Sheffler, Ravinder Nagpal
Alzheimer’s disease (AD) is a debilitating brain disorder with rapidly mounting prevalence worldwide, yet no proven AD cure has been discovered. Using a multi-omics approach in a transgenic AD mous...
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Shotgun metagenomics and systemic targeted metabolomics highlight indole-3-propionic acid as a protective gut microbial metabolite against influenza infection Gut Microbes (IF 12.2) Pub Date : 2024-03-06 Séverine Heumel, Vinícius de Rezende Rodovalho, Charlotte Urien, Florian Specque, Patrícia Brito Rodrigues, Cyril Robil, Lou Delval, Valentin Sencio, Amandine Descat, Lucie Deruyter, Stéphanie Ferreira, Marina Gomes Machado, Adeline Barthelemy, Fabiola Silva Angulo, Joel. T Haas, Jean François Goosens, Isabelle Wolowczuk, Corinne Grangette, Yves Rouillé, Ghjuvan Grimaud, Marie Lenski, Benjamin Hennart
The gut-to-lung axis is critical during respiratory infections, including influenza A virus (IAV) infection. In the present study, we used high-resolution shotgun metagenomics and targeted metabolo...
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Bifidobacterium alleviate metabolic disorders via converting methionine to 5’-methylthioadenosine Gut Microbes (IF 12.2) Pub Date : 2024-03-04 Qiang Lyu, Rou-An Chen, Hsiao-Li Chuang, Hsin-Bai Zou, Lihong Liu, Li-Kang Sung, Po-Yu Liu, Hsin-Yi Wu, Hsin-Yuan Chang, Wan-Ju Cheng, Wei-Kai Wu, Ming-Shiang Wu, Cheng-Chih Hsu
Dietary patterns and corresponding gut microbiota profiles are associated with various health conditions. A diet rich in polyphenols, primarily plant-based, has been shown to promote the growth of ...
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IgA-mediated control of host-microbial interaction during weaning reaction influences gut inflammation Gut Microbes (IF 12.2) Pub Date : 2024-03-04 Wenjie Tang, Yusen Wei, Zhixiang Ni, Kangwei Hou, Xin M. Luo, Haifeng Wang
The mechanisms of how host-microbe mutualistic relationships are established at weaning contingently upon B-cell surveillance remain inadequately elucidated. We found that CD138+ plasmacyte (PC)-me...
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Bile acid profiling as an effective biomarker for staging in pediatric inflammatory bowel disease Gut Microbes (IF 12.2) Pub Date : 2024-03-04 Wei Chen, Daosheng Wang, Xing Deng, Hong Zhang, Danfeng Dong, Tongxuan Su, Qiuya Lu, Cen Jiang, Qi Ni, Yingchao Cui, Qianli Zhao, Xuefeng Wang, Yuan Xiao, Yibing Peng
Rapid and accurate clinical staging of pediatric patients with inflammatory bowel disease (IBD) is crucial to determine the appropriate therapeutic approach. This study aimed to identify effective,...
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A metagenomic prospective cohort study on gut microbiome composition and clinical infection in small bowel transplantation Gut Microbes (IF 12.2) Pub Date : 2024-03-04 Archana Madhav, Rachel Bousfield, Joana Pereira-Dias, Claire Cormie, Sally Forrest, Jacqueline Keane, Leanne Kermack, Ellen Higginson, Gordon Dougan, Harry Spiers, Dunecan Massey, Lisa Sharkey, Charlotte Rutter, Jeremy Woodward, Neil Russell, Irum Amin, Andrew Butler, Kayleigh Atkinson, Tom Dymond, Josefin Bartholdson Scott, Stephen Baker, Effrossyni Gkrania-Klotsas
Two-thirds of small-bowel transplantation (SBT) recipients develop bacteremia, with the majority of infections occurring within 3 months post-transplant. Sepsis-related mortality occurs in 31% of p...
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Gut microbiota-palmitoleic acid-interleukin-5 axis orchestrates benzene-induced hematopoietic toxicity Gut Microbes (IF 12.2) Pub Date : 2024-03-04 Lei Zhang, Ziyan Liu, Wei Zhang, Jingyu Wang, Huiwen Kang, Jiaru Jing, Lin Han, Ai Gao
Due to the annual increase in its production and consumption in occupational environments, the adverse blood outcomes caused by benzene are of concern. However, the mechanism of benzene-induced hem...
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Maternal smoking during pregnancy increases the risk of gut microbiome-associated childhood overweight and obesity Gut Microbes (IF 12.2) Pub Date : 2024-03-04 Ye Peng, Hein M Tun, Siew C Ng, Hogan Kok-Fung Wai, Xi Zhang, Jaclyn Parks, Catherine J Field, Piush Mandhane, Theo J Moraes, Elinor Simons, Stuart E Turvey, Padmaja Subbarao, Jeffrey R Brook, Tim K Takaro, James A Scott, Francis KL Chan, Anita L Kozyrskyj
Childhood obesity is linked to maternal smoking during pregnancy. Gut microbiota may partially mediate this association and could be potential targets for intervention; however, its role is underst...
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A metatranscriptomics strategy for efficient characterization of the microbiome in human tissues with low microbial biomass Gut Microbes (IF 12.2) Pub Date : 2024-02-29 Joana Pereira-Marques, Rui M. Ferreira, Ceu Figueiredo
The high background of host RNA poses a major challenge to metatranscriptome analysis of human samples. Hence, metatranscriptomics has been mainly applied to microbe-rich samples, while its applica...
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Advancing lifelong precision medicine for cardiovascular diseases through gut microbiota modulation Gut Microbes (IF 12.2) Pub Date : 2024-02-27 Bozhong Shi, Haoyu Li, Xiaomin He
The gut microbiome is known as the tenth system of the human body that plays a vital role in the intersection between health and disease. The considerable inter-individual variability in gut microb...
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The colibactin-producing Escherichia coli alters the tumor microenvironment to immunosuppressive lipid overload facilitating colorectal cancer progression and chemoresistance Gut Microbes (IF 12.2) Pub Date : 2024-02-28 Nilmara de Oliveira Alves, Guillaume Dalmasso, Darja Nikitina, Amaury Vaysse, Richard Ruez, Lea Ledoux, Thierry Pedron, Emma Bergsten, Olivier Boulard, Lora Autier, Sofian Allam, Laurence Motreff, Pierre Sauvanet, Diane Letourneur, Pragya Kashyap, Johan Gagnière, Denis Pezet, Catherine Godfraind, Michel Salzet, Emmanuel Lemichez, Mathilde Bonnet, Imène Najjar, Christophe Malabat, Marc Monot, Denis
Intratumoral bacteria flexibly contribute to cellular and molecular tumor heterogeneity for supporting cancer recurrence through poorly understood mechanisms. Using spatial metabolomic profiling te...
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Multi-omics reveals deoxycholic acid modulates bile acid metabolism via the gut microbiota to antagonize carbon tetrachloride-induced chronic liver injury Gut Microbes (IF 12.2) Pub Date : 2024-02-28 Li Zhang, Zhiyi Zheng, Huanhuan Huang, Ya Fu, Tianbin Chen, Can Liu, Qiang Yi, Caorui Lin, Yongjun Zeng, Qishui Ou, Yongbin Zeng
Deoxycholic acid (DCA) serves essential functions in both physiological and pathological liver processes; nevertheless, the relationship among DCA, gut microbiota, and metabolism in chronic liver i...
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The intestinal microbiome of inflammatory bowel disease across the pediatric age range Gut Microbes (IF 12.2) Pub Date : 2024-02-25 Máire A. Conrad, Kyle Bittinger, Yue Ren, Kelly Kachelries, Jennifer Vales, Hongzhe Li, Gary D. Wu, Frederic D. Bushman, Marcella Devoto, Robert N Baldassano, Judith R. Kelsen
Dysbiosis is associated with pediatric and adult-onset inflammatory bowel disease (IBD), but the role of dysbiosis and the microbiome in very early onset IBD (VEO-IBD) has not yet been described. H...
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Regulation of colonic neuropeptide Y expression by the gut microbiome in patients with ulcerative colitis and its association with anxiety- and depression-like behavior in mice Gut Microbes (IF 12.2) Pub Date : 2024-02-25 Min-Kyung Joo, Jae-Won Lee, Jeong-Hwa Woo, Hyo-Jong Kim, Dong-Hyun Kim, Jung-Hye Choi
Patients with inflammatory bowel disease (IBD), including ulcerative colitis (UC), show an increased incidence of anxiety and depression; however, the association between UC-associated psychiatric ...
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Roles of microbiota in pancreatic cancer development and treatment Gut Microbes (IF 12.2) Pub Date : 2024-02-27 Mariana Santos Cruz, Joseph Tintelnot, Nicola Gagliani
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with poor prognosis. This is due to the fact that most cases are only diagnosed at an advanced and palliative disease stage, and the...
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The Helicobacter pylori cag pathogenicity island as a determinant of gastric cancer risk Gut Microbes (IF 12.2) Pub Date : 2024-02-23 Sirena C. Tran, Kaeli N. Bryant, Timothy L. Cover
Helicobacter pylori strains can be broadly classified into two groups based on whether they contain or lack a chromosomal region known as the cag pathogenicity island (cag PAI). Colonization of the...
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A tailored series of engineered yeasts for the cell-dependent treatment of inflammatory bowel disease by rational butyrate supplementation Gut Microbes (IF 12.2) Pub Date : 2024-02-21 Jiahao Wu, He Huang, Lina Wang, Mengxue Gao, Shuxian Meng, Shaolan Zou, Yuanhang Feng, Zeling Feng, Zhixin Zhu, Xiaocang Cao, Bingzhi Li, Guangbo Kang
Intestinal microbiota dysbiosis and metabolic disruption are considered essential characteristics in inflammatory bowel disorders (IBD). Reasonable butyrate supplementation can help patients regula...
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S-amlodipine induces liver inflammation and dysfunction through the alteration of intestinal microbiome in a rat model Gut Microbes (IF 12.2) Pub Date : 2024-02-24 Xinxin Liu, Hui Fang, Liuzhu Pan, Peng Zhang, Huai Lin, Huihui Gao, Chaolin Ye, Daqing Mao, Yi Luo
S-amlodipine, a commonly prescribed antihypertensive agent, is widely used in clinical settings to treat hypertension. However, the potential adverse effects of long-term S-amlodipine treatment on ...
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Chemotherapy-induced microbiota exacerbates the toxicity of chemotherapy through the suppression of interleukin-10 from macrophages Gut Microbes (IF 12.2) Pub Date : 2024-02-24 Zhen He, Hongyu Xie, Haoyang Xu, Jinjie Wu, Wanyi Zeng, Qilang He, Christian Jobin, Sanqing Jin, Ping Lan
The gut microbiota has been shown to influence the efficacy and toxicity of chemotherapy, thereby affecting treatment outcomes. Understanding the mechanism by which microbiota affects chemotherapeu...
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B. longum CKD1 enhances the efficacy of anti-diabetic medicines through upregulation of IL- 22 response in type 2 diabetic mice Gut Microbes (IF 12.2) Pub Date : 2024-02-23 Won Jun Kim, Bum Ju Kil, Chaewon Lee, Tae Young Kim, Goeun Han, Yukyung Choi, Kyunghwan Kim, Chang Hun Shin, Seung-Young Park, Heebal Kim, Myunghoo Kim, Chul Sung Huh
The gut microbiota plays a pivotal role in metabolic disorders, notably type 2 diabetes mellitus (T2DM). In this study, we investigated the synergistic potential of combining the effects of Bifidob...
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Colibactin-producing Escherichia coli enhance resistance to chemotherapeutic drugs by promoting epithelial to mesenchymal transition and cancer stem cell emergence Gut Microbes (IF 12.2) Pub Date : 2024-02-19 Guillaume Dalmasso, Antony Cougnoux, Tiphanie Faïs, Virginie Bonnin, Benoit Mottet-Auselo, Hang TT Nguyen, Pierre Sauvanet, Nicolas Barnich, Marine Jary, Denis Pezet, Julien Delmas, Richard Bonnet
Human colorectal cancers (CRCs) are readily colonized by colibactin-producing E. coli (CoPEC). CoPEC induces DNA double-strand breaks, DNA mutations, genomic instability, and cellular senescence. I...
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The biotherapeutic Clostridium butyricum MIYAIRI 588 strain potentiates enterotropism of Rorγt+Treg and PD-1 blockade efficacy Gut Microbes (IF 12.2) Pub Date : 2024-02-22 Thomas Paz Del Socorro, Kentaro Oka, Olivier Boulard, Motomichi Takahashi, Lionel Franz Poulin, Atsushi Hayashi, Mathias Chamaillard
Immune checkpoint inhibitors (ICI) have been positioned as a standard of care for patients with advanced non-small-cell lung carcinomas (NSCLC). A pilot clinical trial has reflected optimistic asso...
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Dietary resistant starch supplementation increases gut luminal deoxycholic acid abundance in mice Gut Microbes (IF 12.2) Pub Date : 2024-02-20 Melanie A. Reuter, Madelynn Tucker, Zara Marfori, Rahaf Shishani, Jessica Miranda Bustamante, Rosalinda Moreno, Michael L. Goodson, Allison Ehrlich, Ameer Y. Taha, Pamela J. Lein, Nikhil Joshi, Ilana Brito, Blythe Durbin-Johnson, Renu Nandakumar, Bethany P. Cummings
Bile acids (BA) are among the most abundant metabolites produced by the gut microbiome. Primary BAs produced in the liver are converted by gut bacterial 7-α-dehydroxylation into secondary BAs, whic...
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Probiotic Lactobacillus spp. improves Drosophila memory by increasing lactate dehydrogenase levels in the brain mushroom body neurons Gut Microbes (IF 12.2) Pub Date : 2024-02-19 Shuk-Man Ho, Wan-Hua Tsai, Chih-Ho Lai, Meng-Hsuan Chiang, Wang-Po Lee, Hui-Yu Wu, Pei-Yi Bai, Tony Wu, Chia-Lin Wu
Probiotics are live microorganisms that offer potential benefits to their hosts and can occasionally influence behavioral responses. However, the detailed mechanisms by which probiotics affect the ...
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Gut microbiota regulates host melatonin production through epithelial cell MyD88 Gut Microbes (IF 12.2) Pub Date : 2024-02-14 Bingnan Liu, Lijuan Fan, Youxia Wang, Hao Wang, Yuqi Yan, Shuai Chen, Ifen Hung, Chunxue Liu, Hong Wei, Liangpeng Ge, Wenkai Ren
Melatonin has various physiological effects, such as the maintenance of circadian rhythms, anti-inflammatory functions, and regulation of intestinal barriers. The regulatory functions of melatonin ...
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Gut enterotype-dependent modulation of gut microbiota and their metabolism in response to xanthohumol supplementation in healthy adults Gut Microbes (IF 12.2) Pub Date : 2024-02-15 Paige E. Jamieson, Eli B. Smart, John A. Bouranis, Jaewoo Choi, Robert E. Danczak, Carmen P. Wong, Ines L. Paraiso, Claudia S. Maier, Emily Ho, Thomas J. Sharpton, Thomas O. Metz, Ryan Bradley, Jan F. Stevens
Xanthohumol (XN), a polyphenol found in the hop plant (Humulus lupulus), has antioxidant, anti-inflammatory, prebiotic, and anti-hyperlipidemic activity. Preclinical evidence suggests the gut micro...
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From a hunger-regulating hormone to an antimicrobial peptide: gastrointestinal derived circulating endocrine hormone-peptide YY exerts exocrine antimicrobial effects against selective gut microbiota Gut Microbes (IF 12.2) Pub Date : 2024-02-14 Yuchen Xiao, Lingjing Jin, Chao Zhang
Published in Gut Microbes (Vol. 16, No. 1, 2024)
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Gut microbiota-derived trimethylamine N-Oxide: a novel target for the treatment of preeclampsia Gut Microbes (IF 12.2) Pub Date : 2024-02-13 Jiayi Wang, Yajie Gao, Shuaijun Ren, Jialin Li, Siqian Chen, Jiating Feng, Bing He, Yuping Zhou, Rongrong Xuan
Pre-eclampsia (PE) is the most common complication of pregnancy and seriously threatens the health and safety of the mother and child. Studies have shown that an imbalance in gut microbiota can aff...
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Salmonella enterica serovar Typhimurium remodels mitochondrial dynamics of macrophages via the T3SS effector SipA to promote intracellular proliferation Gut Microbes (IF 12.2) Pub Date : 2024-02-14 Xingmei Liu, Yutao Liu, Xinyu Zhao, Xueping Li, Ting Yao, Ruiying Liu, Qian Wang, Qiushi Wang, Dan Li, Xintong Chen, Bin Liu, Lu Feng
Mitochondrial dynamics are critical in cellular energy production, metabolism, apoptosis, and immune responses. Pathogenic bacteria have evolved sophisticated mechanisms to manipulate host cells’ m...