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Invigorating human MSCs for transplantation therapy via Nrf2/DKK1 co-stimulation in an acute-on-chronic liver failure mouse model Gastroenterol. Rep. (IF 3.6) Pub Date : 2024-03-25 Feng Chen, Zhaodi Che, Yingxia Liu, Pingping Luo, Lu Xiao, Yali Song, Cunchuan Wang, Zhiyong Dong, Mianhuan Li, George L Tipoe, Min Yang, Yi Lv, Hong Zhang, Fei Wang, Jia Xiao
Background Since boosting stem cell resilience in stressful environments is critical for the therapeutic efficacy of stem cell-based transplantations in liver disease, this study aimed to establish the efficacy of a transient plasmid-based preconditioning strategy for boosting the capability of mesenchymal stromal cells (MSCs) for anti-inflammation/antioxidant defenses and paracrine actions in recipient
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Fecal microbiota related to postoperative endoscopic recurrence in patients with Crohn's disease Gastroenterol. Rep. (IF 3.6) Pub Date : 2024-03-24 Haichao Wang, Guorong Yan, Yaling Wu, Deji Zhuoma, Zhanju Liu, Xuefeng Gao, Xiaolei Wang
Background Postoperative recurrence (POR) remains a major challenge for patients with Crohn’s disease (CD). Gut microbial dysbiosis has been reported to be involved in the pathogenesis of POR. This study aims to investigate the relationship between fecal microbiome and endoscopic recurrence in patients with CD after ileocolonic resection. Methods This is a cross-sectional study. Fecal samples were
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Safety and feasibility of minimally invasive gastrectomy after neoadjuvant immunotherapy for locally advanced gastric cancer: a propensity score-matched analysis in China Gastroenterol. Rep. (IF 3.6) Pub Date : 2024-02-29 Hao Cui, Wenquan Liang, Jianxin Cui, Liqiang Song, Zhen Yuan, Lin Chen, Bo Wei
Background The effect of neoadjuvant immunotherapy on minimally invasive gastrectomy (MIG) for locally advanced gastric cancer (LAGC) remains controversial. This study aimed to compare short-term outcomes between MIG after neoadjuvant chemo-immunotherapy (NICT-MIG) and MIG after neoadjuvant chemotherapy alone (NCT-MIG), and determine risk factors for post-operative complications (POCs). Methods This
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Deregulation of circRNA hsa_circ_0009109 promotes tumor growth and initiates autophagy by sponging miR-544a-3p in gastric cancer Gastroenterol. Rep. (IF 3.6) Pub Date : 2024-02-29 Weiwei Zhang, Qian Yang, Dongchen Qian, Keli Zhao, Chenxue Tang, Shaoqing Ju
Background Autophagy death of cancer cells is detrimental to apoptosis induced by therapeutic drugs, which promotes tumor progression to a certain extent. Increasing reports have demonstrated the regulatory role of circular RNAs (circRNAs) in autophagy. Here, we aimed to determine the role of hsa_circ_0009109 in autophagy in gastric cancer (GC). Methods The effects of hsa_circ_0009109 on autophagy
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Prediction of immunocyte infiltration and prognosis in postoperative hepatitis B virus-related hepatocellular carcinoma patients using magnetic resonance imaging Gastroenterol. Rep. (IF 3.6) Pub Date : 2024-02-27 Chenyu Song, Mengqi Huang, Xiaoqi Zhou, Yuying Chen, Zhoulei Li, Mimi Tang, Meicheng Chen, Zhenpeng Peng, Shiting Feng
Background The immune microenvironment (IME) is closely associated with prognosis and therapeutic response of hepatitis B virus-related hepatocellular carcinoma (HBV-HCC). Multi-parametric magnetic resonance imaging (MRI) enables non-invasive assessment of IME and predicts prognosis in HBV-HCC. We aimed to construct an MRI prediction model of the immunocyte-infiltration subtypes and explore its prognostic
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Laparoscopic cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for gastric cancer with intraoperative detection of limited peritoneal metastasis: a Phase II study of CLASS-05 trial Gastroenterol. Rep. (IF 3.6) Pub Date : 2024-02-22 Tian Lin, Xinhua Chen, Zhijun Xu, Yanfeng Hu, Hao Liu, Jiang Yu, Guoxin Li
Background Systemic chemotherapy for gastric cancer with peritoneal metastasis has limited clinical benefit; for those with intraoperative detection of occult peritoneal metastasis, cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (HIPEC) is an alternative treatment. However, the feasibility and effects of this modality and criteria for selecting suitable groups remain unclear
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Association between low-normal thyroid function and advanced liver fibrosis in metabolic dysfunction-associated fatty liver disease patients: a retrospective cohort study Gastroenterol. Rep. (IF 3.6) Pub Date : 2024-01-23 Zixuan Li, Xiaoying Wu, Zebin Chen, Xiuqing Wei, Weiqing Chen
Background Recent studies have found that thyroid function may be associated with the occurrence and development of advanced liver fibrosis in patients with metabolic dysfunction-associated fatty liver disease (MAFLD). However, the majority of such research has consisted of cross-sectional studies. This retrospective cohort study aimed to investigate the effect of low-normal thyroid function on advanced
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Hepatitis C virus point-of-care microelimination approach in a vulnerable population in the South of Spain Gastroenterol. Rep. (IF 3.6) Pub Date : 2024-01-23 José María Pinazo-Bandera, Jesús Aranda, Alberto Manuel García-García, Ramiro Alcántara, Aida Ortega-Alonso, Enrique Del Campo-Herrera, Encarnación Clavijo, M Dolores García-Escaño, Juan Jesús Ruiz Ruiz, Mónica Morales-Herrera, Vanesa Valle-López, Rosa Martín-Alarcón, Isabel Viciana, Juan Bautista Jiménez, Felix Fernández-García, Juan Pedro Toro-Ortiz, Elena Sánchez-Yáñez, Ismael Álvarez-Álvarez, Raúl
Background Since the introduction of direct-acting antivirals, thousands of chronic hepatitis C patients have been successfully treated. However, vulnerable populations have a higher prevalence of hepatitis C virus (HCV) infection and face barriers that impede their access to antivirals. We carried out an HCV microelimination program focused on vulnerable population groups in Malaga. Methods People
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Independent and additive effects of binge drinking and obesity on liver enzymes: a cross-sectional analysis using the Korean National Health Insurance Service data Gastroenterol. Rep. (IF 3.6) Pub Date : 2024-01-12 Anthony Kityo, Sang-Ah Lee
Background Binge drinking (BD) has been associated with elevated liver enzymes, but the joint association of BD and adiposity with liver enzymes is understudied. We aimed to examine the combined association of BD and obesity with elevated liver enzymes. Methods Data were obtained from 285,600 patients in the Korean National Health check-up program during 2009–2015. Level I BD (BD I) was defined as
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A new membrane anatomy-oriented classification of radical surgery for rectal cancer Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-12-22 Jiaqi Wang, Hailong Liu, Ajian Li, Huihong Jiang, Yun Pan, Xin Chen, Lu Yin, Moubin Lin
For patients with different clinical stages of rectal cancer, tailored surgery is urgently needed. Over the past 10 years, our team has conducted numerous anatomical studies and proposed the “four fasciae and three spaces” theory to guide rectal cancer surgery. Enlightened by the anatomical basis of the radical hysterectomy classification system of Querleu and Morrow, we proposed a new classification
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Dual function of fungi-derived cytokines in inflammatory bowel diseases: protection or inflammation Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-12-05 Niusha Sharifinejad, Elaheh Mahmoudi
Inflammatory bowel disease (IBD) is an immune-mediated inflammatory condition involving both the innate and adaptive immune systems. Recently, the role of intestinal fungal flora and their downstream immune pathways has been highlighted in the pathogenesis of IBD. Cytokines as primary immune mediators require a delicate balance for maintaining intestinal homeostasis. Although most cytokines have a
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Association between adjuvant chemotherapy and survival in stage I gastric cancer patients after curative resection Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-12-05 Qiuying Chen, Hua Xiao, Lu Zhang, Jingjing You, Zhe Jin, Bin Zhang
Background The efficacy of adjuvant chemotherapy (AC) on survival outcomes of patients with stage I gastric cancer (GC) after curative resection remains controversial. We aimed to determine whether these patients would benefit from AC. Methods This retrospective study included patients with pathologically confirmed stage I GC who underwent curative resection between November 2010 and December 2020
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Ileorectal intussusception in an adult: a case report of an anal mass. Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-10-31 Azin Kalani,Mina Alvandipour
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Pancreatolithiasis with an anatomic variant of Wirsung duct: a case report. Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-10-26 Satoshi Yamamoto,Kazuo Inui,Yoshiaki Katano,Senju Hashimoto,Hironao Miyoshi,Takashi Kobayashi,Yoshihiko Tachi
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Unveiling mitophagy-mediated molecular heterogeneity and development of a risk signature model for colorectal cancer by integrated scRNA-seq and bulk RNA-seq analysis. Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-10-24 Han Gao,Qi Zou,Linyun Ma,Keyu Cai,Yi Sun,Li Lu,Donglin Ren,Bang Hu
Background Accumulating researchers have recognized mitophagy as a key player in tumors, but few studies have investigated its role in the tumor microenvironment (TME). Advances in the technology of single-cell RNA sequencing (scRNA-seq) have allowed unveiling the concealed features of the TME at cellular resolution. This study aimed to elucidate the role of mitophagy within the TME of colorectal cancer
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Effect of BRAF mutation on the prognosis for patients with colorectal cancer undergoing cytoreductive surgery for synchronous peritoneal metastasis. Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-10-24 Zhijie Wu,Xiusen Qin,Yuanxin Zhang,Jian Luo,Rui Luo,Zonglu Cai,Hui Wang
Background KRAS/BRAF mutations (mutKRAS/mutBRAF) are unfavorable prognostic factors for colorectal cancer (CRC) metastases to the liver and lungs. However, their effects on the prognosis for patients with synchronous peritoneal metastasis (S-PM) of CRC after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are controversial. In the study, we aimed to determine the effects
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Long-term follow-up of endoscopic papillectomy and the value of preventive pancreatic stent placement (with videos) Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-10-19 Yuling Wang, Xiaoqing Zhang, Zhenhua Yang, Teng Wang, Dongqing Zhu, Jie Gao, Ping-Ping Zhang, Peiqin Wang, Xingang Shi
Background Early-stage ampullary adenomas have only been reported in a small case series on endoscopic management. Hence, this study aimed to evaluate the long-term outcomes of early ampullary adenoma with endoscopic management and identify the risk factors for acute pancreatitis after endoscopic papillectomy (EP). Methods In this study, 115 patients who underwent EP at Changhai Hospital (Shanghai
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Endoscopic ultrasound-guided injection of carbon nanoparticles suspension to label rectal cancer before neoadjuvant chemoradiotherapy: a retrospective cohort study Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-10-13 Nan Lin, Yuanzhao Wang, Changwei Yu, Weihang Wu, Yongchao Fang, Jin Yang, Wangwu Liu, Rong Wang, Yanyan Jiang, Yu Wang
Background Localization of the primary tumor and ensuring safe distal surgical margins (DSMs) following neoadjuvant chemoradiotherapy (nCRT) are challenging in locally advanced rectal cancers (LARCs). This study investigated the effectiveness of carbon nanoparticles suspension (CNS) for labeling the primary tumor and allowing precise tumor resection after nCRT. Methods Clinicopathological data of LARC
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Comparison of clinical efficacy between LAPS and ALPPS in the treatment of hepatitis B virus-related hepatocellular carcinoma Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-10-13 Zebin Chen, Shunli Shen, Wenxuan Xie, Junbin Liao, Shiting Feng, Shaoqiang Li, Jiehui Tan, Ming Kuang
Background Insufficient post-operative future liver remnant (FLR) limits the feasibility of hepatectomy for patients. Staged hepatectomy is an effective surgical approach that can improve the resection rate of hepatocellular carcinoma (HCC). This study aimed to compare the safety and efficacy of laparoscopic microwave ablation and portal vein ligation for staged hepatectomy (LAPS) and classical associating
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RIFLE: a Phase II trial of stereotactic ablative radiotherapy combined with fruquintinib and tislelizumab in metastatic colorectal cancer Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-10-12 Kun Wang, Yajie Chen, Zhiyuan Zhang, Ruiyan Wu, Menglong Zhou, Wang Yang, Juefeng Wan, Lijun Shen, Hui Zhang, Yan Wang, Xu Han, Jiazhou Wang, Zhen Zhang, Fan Xia
Background Currently, the prognosis for metastatic colorectal cancer (mCRC) still remains poor. The management of mCRC has become manifold because of the varied advances in the systemic and topical treatment approaches. For patients with limited number of metastases, radical local therapy plus systemic therapy can be a good choice to achieve long-term tumor control. In this study, we aimed to explore
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Predicted pro-inflammatory hs-CRP score and non-alcoholic fatty liver disease Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-10-12 Akinkunmi Paul Okekunle, Jiyoung Youn, Sihan Song, Goh Eun Chung, Sun Young Yang, Young Sun Kim, Jung Eun Lee
Background Non-alcoholic fatty liver disease (NAFLD) is a major contributor to liver diseases globally, yet there are limited studies investigating the impact of diet and lifestyle factors on its development. This study aimed to examine the association between the prevalence of NAFLD and predicted pro-inflammatory high-sensitivity C-reactive protein (hs-CRP) score. Methods We included 1,076 Korean
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Evidence challenging the causal role of gut microbiota in inflammatory bowel diseases. Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-10-11 Na Jiao,Xiao Ke,Lixin Zhu,Ruixin Zhu
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Current complementary and alternative therapy forgastroesophageal reflux disease. Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-10-04 Dianxuan Jiang,Qianjun Zhuang,Xingyu Jia,Songfeng Chen,Niandi Tan,Mengyu Zhang,Yinglian Xiao
Gastroesophageal reflux disease (GERD) is a widely prevalent gastrointestinal disorder, affecting ∼13.3% of the global population. There are shortages and limitations of current GERD treatment modalities, and complementary and alternative therapy (CAT) is a promising option to fill in the gap. Dietary and lifestyle modifications might play an important and complementary role in alleviating GERD symptoms
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Application of near-infrared fluorescence imaging in theranostics of gastrointestinal tumors. Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-09-27 Nan-Qing Shi,Xin-Yuan Cui,Cheng Zhou,Ning Tang,Da-Xiang Cui
Gastrointestinal cancers have become an important cause of cancer-related death in humans. Improving the early diagnosis rate of gastrointestinal tumors and improving the effect of surgical treatment can significantly improve the survival rate of patients. The conventional diagnostic method is high-definition white-light endoscopy, which often leads to missed diagnosis. For surgical treatment, intraoperative
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Rapidly growing primary anal canal lymphoma: a case report and literature review. Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-09-22 Yu Kyung Chung,Su Bum Park
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Cancer risk and mortality in patients with solitary Peutz-Jeghers polyps. Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-09-22 Anne Marie Jelsig,Laus Wullum,Lilian Bomme Ousager,Johan Burish,Tine Plato Kühlmann,John Gásdal Karstensen
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Mirror, mirror on the wall, who is the best of them all? Artificial intelligence versus gastroenterologists in solving clinical problems. Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-09-22 Felice Benedicenti,Tommaso Pessarelli,Mattia Corradi,Marco Michelon,Nicoletta Nandi,Pietro Lampertico,Maurizio Vecchi,Lucia Scaramella,Luca Elli
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Association of food intake with a risk of metabolic dysfunction-associated fatty liver disease: a cross-sectional study. Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-09-11 Xian-Hua Huang,He-Wei Peng,Jing-Ru Huang,Rong Yu,Zhi-Jian Hu,Xian-E Peng
Background Metabolic dysfunction-associated fatty liver disease (MAFLD) is a common liver disease, the risk of which can be increased by poor diet. The objective of this study was to evaluate the associations between food items and MAFLD, and to propose reasonable dietary recommendations for the prevention of MAFLD. Methods Physical examination data were collected from April 2015 through August 2017
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Clinical relevance of salivary pepsin detection in diagnosing gastroesophageal reflux disease subtypes Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-09-10 Mengyu Zhang, Tingting Wu, Niandi Tan, Songfeng Chen, Qianjun Zhuang, Yu Luo, Yinglian Xiao
Background Gastroesophageal reflux disease (GERD) is heterogeneous with a varied symptom spectrum and reflux profiles. Its definite diagnosis often requires invasive tools including endoscopy or reflux monitoring. The aim of this study was to investigate the clinical relevance of salivary pepsin detection as a non-invasive screening tool to diagnose GERD of different subtypes. Methods A total of 77
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Novel per-oral cholangioscopy for treatment of occult accessory hepatic duct stones. Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-08-30 Tingting Yu,Yaoting Li,Hongfei He,Senlin Hou,Lichao Zhang
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Identification and genetic counseling for a novel variant of MLH1 associated with lynch syndrome in colorectal cancer: a case report. Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-08-23 Xiaohuan Lu,Hongyan Zhang,Luming Xu,Yang Cao,Yuan Li,Wei Li,Gang Li,Feng Xue,Zheng Wang
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Efficacy and complications of inoperable malignant distal biliary obstruction treatment by metallic stents: fully covered or uncovered? Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-08-23 Jiangning Gu, Xiaoyi Guo, Yong Sun, Bin Fan, Haoran Li, Ting Luo, Haifeng Luo, Jiao Liu, Feng Gao, Yuan Gao, Guang Tan, Xiaoming Liu, Zhuo Yang
Obstructive jaundice caused by malignant distal biliary obstruction is a common clinical symptom in patients with inoperable biliary–pancreatic cancer. Endoscopic retrograde cholangiopancreatography (ERCP)-guided stent implantation is an effective treatment for obstructive jaundice. Internal stent drainage is more physiologic and associated with a better quality of life than external stent drainage
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Drug reaction with eosinophilia and systemic symptoms syndrome secondary to Chinese oral herbal paste: a case report. Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-08-12 Weiyun Jiang,Yunhao Xun
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Routine nasogastric tube placement in patients with small esophageal perforation after endoscopic foreign body removal may be unnecessary: a propensity score matching analysis Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-07-29 Foqiang Liao, Qinyu Yang, Zhenyi Zhan, Zhenhua Zhu, Xiaolin Pan, Chong Wang, Bimin Li, Yin Zhu, Youxiang Chen, Xu Shu
Background Nasogastric tube (NGT) placement is part of the post-operative management of upper gastrointestinal perforation, but its routine use in esophageal perforation (EP) caused by foreign bodies remains unclear. The purpose of this research was to investigate the necessity for routine NGT placement in patients with EP after endoscopic foreign body removal. Methods A total of 323 patients diagnosed
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Emergency department utilization for gastrointestinal care and patient characteristics associated with hospital admission in a national cohort. Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-07-27 Kelly Suchman,Nina Kohn,Arvind J Trindade
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Learning curves of resection and reconstruction procedures in robotic-assisted pancreatoduodenectomy by a single surgeon: a retrospective cohort study of 160 consecutive cases Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-07-26 Xi-Tai Huang, Xi-Yu Wang, Jin-Zhao Xie, Jian-Peng Cai, Wei Chen, Liu-Hua Chen, Xiao-Yu Yin
Background Robotic-assisted pancreatoduodenectomy (RPD) has been routinely performed in a few of centers worldwide. This study aimed to evaluate the perioperative outcomes and the learning curves of resection and reconstruction procedures in RPD by one single surgeon. Methods Consecutive patients undergoing RPD by a single surgeon at the First Affiliated Hospital of Sun Yat-sen University (Guangzhou
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Advances in endobariatrics: past, present, and future Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-07-21 Abhishek Shenoy, Allison R Schulman
The obesity epidemic in the USA and worldwide is well documented and continues to grow. Endoscopic metabolic and bariatric therapies may offer a less invasive approach than surgical intervention. This article will review advances in endobariatrics over the last several decades, addressing the past and current state of bariatric and metabolic endoscopy. Food and Drug Administration-cleared devices and
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Exploration of the shared gene signatures and molecular mechanisms between periodontitis and inflammatory bowel disease: evidence from transcriptome data Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-07-14 Chi Zhan, Zhaocai Zhou, Yaxian Huang, Shuheng Huang, Zhengmei Lin, Feng He, Zhi Song
Background Periodontitis disease (PD) is associated with a systemic disorder of inflammatory bowel disease (IBD). The immune response is the common feature of the two conditions, but the more precise mechanisms remain unclear. Methods Differential expressed genes (DEGs) analysis and weighted gene co-expression network analysis (WGCNA) were performed on PD and Crohn's disease (CD) data sets to identify
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Clinical features of gastric adenoma detected within 3 years after negative screening endoscopy in Korea Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-07-04 Hyun Young Kim
Background Early detection and management of gastric adenoma are important for preventing gastric cancer. The present study aimed to evaluate the predictors of missed gastric adenoma on screening endoscopy in Korea and identify the risk factors associated with interval precancerous gastric lesions. Methods All cases of gastric adenomas diagnosed via screening endoscopy between 2007 and 2019 were reviewed
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Extremely severe hypochloremic metabolic alkalosis after ileorectal anastomosis in a patient with chronic intestinal pseudo-obstruction. Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-06-30 Peter Heinz-Erian,Andreas R Janecke,Thomas Müller,Peter Rehder,Elisabeth Bruder,Thomas Menter,Heinz Zoller,Markus Pirklbauer,Michael Rieger
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Hirschsprung disease in an adult masquerading as stricturing Crohn's disease: a missed rare co-morbidity. Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-06-30 Yiqian Chen,Xiaowei Liu,Shuijiao Chen
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Preliminary surgical outcomes of laparoscopic right hemicolectomy with transrectal specimen extraction: a propensity score matching study of 120 cases (with video) Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-06-30 Mingguang Zhang, Zheng Liu, Peng Sun, Xiyue Hu, Haitao Zhou, Zheng Jiang, Jianqiang Tang, Qian Liu, Xishan Wang
Background Compared with conventional laparoscopic surgery, natural orifice specimen extraction surgery (NOSES) has many advantages. Laparoscopic right colectomy with transvaginal specimen extraction has been reported, but the safety and feasibility of transrectal specimen extraction in male patients with ascending colon cancer remain to be verified. This study aimed to preliminarily evaluate the feasibility
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Evolution of interventional endoscopic ultrasound Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-06-30 Mark J Radlinski, Daniel S Strand, Vanessa M Shami
Endoscopic ultrasound (EUS) has become an indispensable modality for the assessment of the gastrointestinal tract and adjacent structures since its origin in the 1980s. Following the development of the linear echoendoscope, EUS has evolved from a purely diagnostic modality to a sophisticated tool for intervention, with numerous luminal, pancreaticobiliary, and hepatic applications. Broadly, these applications
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Liver resection versus liver transplantation for hepatocellular carcinoma within the Milan criteria based on estimated microvascular invasion risks Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-06-27 Pinghua Yang, Fei Teng, Shilei Bai, Yong Xia, Zhihao Xie, Zhangjun Cheng, Jun Li, Zhengqing Lei, Kui Wang, Baohua Zhang, Tian Yang, Xuying Wan, Hao Yin, Hao Shen, Timothy M Pawlik, Wan Yee Lau, Zhiren Fu, Feng Shen
Background Preoperative prediction of microvascular invasion (MVI) in hepatocellular carcinoma (HCC) may optimize individualized treatment decision-making. This study aimed to investigate the prognostic differences between HCC patients undergoing liver resection (LR) and liver transplantation (LT) based on predicted MVI risks. Methods We analysed 905 patients who underwent LR, including 524 who underwent
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Dynamic heterogeneity of colorectal cancer during progression revealed clinical risk-associated cell types and regulations in single-cell resolution and spatial context Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-06-25 Haoxian Ke, Zhihao Li, Peisi Li, Shubiao Ye, Junfeng Huang, Tuo Hu, Chi Zhang, Ming Yuan, Yuan Chen, Xianrui Wu, Ping Lan
Background Tumor heterogeneity is contributed by tumor cells and the microenvironment. Dynamics of tumor heterogeneity during colorectal cancer (CRC) progression have not been elucidated. Methods Eight single-cell RNA sequencing (scRNA-seq) data sets of CRC were included. Milo was utilized to reveal the differential abundance of cell clusters during progression. The differentiation trajectory was imputed
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Aquaporin 9 is involved in CRC metastasis through DVL2-dependent Wnt/β-catenin signaling activation Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-06-24 Yiting Liu, Qianling Gao, Xingzhi Feng, Guanxing Chen, Xuefei Jiang, Daici Chen, Zihuan Yang
Background Aquaporin 9 (AQP9) is permeable to water or other small molecules, and plays an important role in various cancers. We previously found that AQP9 was related to the efficacy of chemotherapy in patients with colorectal cancer (CRC). This study aimed to identify the role and regulatory mechanism of AQP9 in CRC metastasis. Methods The clinical significance of AQP9 was analysed by using bioinformatics
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The molecular pathogenesis of achalasia: a paired lower esophageal sphincter muscle and serum 4D label-free proteomic study Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-06-13 Songfeng Chen, Xiangbin Xing, Xun Hou, Qianjun Zhuang, Niandi Tan, Yi Cui, Jinhui Wang, Mengyu Zhang, Shixian Hu, Yinglian Xiao
Background Achalasia is a primary esophageal motility disorder with potential molecular pathogenesis remaining uncertain. This study aimed to identify the differentially expressed proteins and potential pathways among achalasia subtypes and controls to further reveal the molecular pathogenesis of achalasia. Methods Paired lower esophageal sphincter (LES) muscle and serum samples from 24 achalasia patients
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Turnkey algorithmic approach for the evaluation of gastroesophageal reflux disease after bariatric surgery Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-06-10 Omar M Ghanem, Rabih Ghazi, Farah Abdul Razzak, Fateh Bazerbachi, Karthik Ravi, Leena Khaitan, Shanu N Kothari, Barham K Abu Dayyeh
Bariatric surgeries are often complicated by de-novo gastroesophageal reflux disease (GERD) or worsening of pre-existing GERD. The growing rates of obesity and bariatric surgeries worldwide are paralleled by an increase in the number of patients requiring post-surgical GERD evaluation. However, there is currently no standardized approach for the assessment of GERD in these patients. In this review
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Berberine alleviates non-alcoholic hepatic steatosis partially by promoting SIRT1 deacetylation of CPT1A in mice Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-06-09 Peng Wang, Ruikai Li, Yuqi Li, Siwei Tan, Jie Jiang, Huiling Liu, Xiuqing Wei
Background Berberine effectively alleviates non-alcoholic fatty liver disease (NAFLD). Nevertheless, the mechanism is incompletely comprehended. It has been reported that SIRT1 mediates lipid metabolism in liver and berberine promotes the expression of SIRT1 in hepatocytes. We hypothesized that SIRT1 mediated the effect of berberine on NAFLD. Methods The effects of berberine on NAFLD were evaluated
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Evaluation of early liquid drinking after radical gastrectomy in gastric cancer: a Chinese multicenter propensity score matching analysis Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-06-08 Yue Zhang, Kaixiong Tao, Jinlong Yu, Chao Chen, Quan Zheng, Sanlin Lei, Xiaogang Zhong, Lixin Liu, Wei Wang, Qiang Wang, En Li, Yuwen Luo, Guanrong Zhang, Xingyu Feng, Yong Li, Junjiang Wang
Background Enhanced recovery after surgery is used in gastrointestinal surgery. This study aimed to access the effects of early liquid drinking (ELD) on gastrointestinal function recovery in patients with gastric cancer (GC) who underwent radical gastrectomy, as high-quality evidence on the outcomes of ELD after gastrectomy is currently lacking. Methods Clinicopathological data of patients with GC
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A novel anastomotic vacuum-assisted closure system for cervical anastomotic fistula after three-incisional esophagectomy. Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-06-07 Yu-Zhen Zheng,Shen-Shen Fu,Xian-Yu Qin,Xing-Ping Yang,Hao-Sheng Zheng,Zui Liu,Shi-Yun He,Wei-Jie Cai,Jian Tan,Bo-Zhu Jian,Hong-Ying Liao
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Clinical characteristics and treatments of cap polyposis: a single center case series. Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-05-30 Yanhua Zhou,Rui Cheng,Ningning Dong,Ying Meng,Chuntao Liu,Ye Zong
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Endoscopic management of colorectal polyps Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-05-28 Pingting Gao, Kaiqian Zhou, Wei Su, Jia Yu, Pinghong Zhou
Colorectal polyps are premalignant lesions in the lower gastrointestinal tract. Endoscopic polypectomy is an effective strategy to prevent colorectal cancer morbidity and more invasive procedures. Techniques for the endoscopic resection of polyps keep evolving, and endoscopists are required to perform the most appropriate technique for each polyp. In this review, we outline the evaluation and classification
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Disseminated intravascular coagulation after splenic artery aneurysm coils embolization: an unexpected surprise. Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-05-25 Marco Biolato,Alessandro D'Errico,Fiammetta Maria Rognoni,Giuseppe Marrone,Luca Laurenti,Alessandro Cina,Antonio Grieco
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A rare case of gastrointestinal bleeding caused by gastric capillary hemangioma. Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-05-17 Yu-Zhen Bi,Si-Jia Yan,Li-Min Zhou,Hong Mou,Yan Sun,Jun Zhang
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Natural history, clinical characteristics, outcomes, and long-term follow-up of pain-free chronic pancreatitis Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-05-05 Awais Ahmed, Ishani Shah, Rachel Bocchino, Steven D Freedman, Darshan J Kothari, Sunil G Sheth
Background Chronic pancreatitis (CP) is characterized by chronic abdominal pain and functional insufficiency. However, a small subset of patients with prior acute pancreatitis (AP) and/or underlying risk factors for developing CP may be pain-free at diagnosis and may have a different clinical course. We aimed to compare the clinical characteristics, outcomes, and healthcare utilization between CP patients
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Esophageal mycobiome landscape and interkingdom interactions in esophageal squamous cell carcinoma Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-04-28 Wen-Qing Rao, Zheng Lin, Jian Jiang, Jian-Wen Wang, Zhi-Feng Lin, Rong Fu, Wei-Lin Chen, Yuan-Mei Chen, Xian-E Peng, Zhi-Jian Hu
Background The study purpose was to characterize the mycobiome and its associations with the expression of pathogenic genes in esophageal squamous cell carcinoma (ESCC). Methods Patients with primary ESCC were recruited from two central hospitals. We performed internal transcribed spacer 1 (ITS1) ribosomal DNA sequencing analysis. We compared differential fungi and explored the ecology of fungi and
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A novel intelligent chromo capsule endoscope for the diagnosis of neoplastic lesions in the gastrointestinal tract Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-04-21 Huiying Shi, Suya Pang, Fanhua Ming, Tianyi Yangdai, Shuxin Tian, Rong Lin
Background Chromoendoscopy has not been fully integrated into capsule endoscopy. This study aimded to develop and validate a novel intelligent chromo capsule endoscope (ICCE). Methods The ICCE has two modes: a white-light imaging (WLI) mode and an intelligent chromo imaging (ICI) mode. The performance of the ICCE in observing colors, animal tissues, and early gastrointestinal (GI) neoplastic lesions
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Current management of gastro-oesophageal reflux disease—treatment costs, safety profile, and effectiveness: a narrative review Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-04-18 Tahmina Lata, Jodie Trautman, Philip Townend, Robert B Wilson
Background The purpose of this study was to review the current management of gastro-oesophageal reflux disease (GORD), including treatment costs, safety profile and effectiveness. Methods A literature review was performed of randomized-controlled trials, systematic reviews, Cochrane reports and National/Societal guidelines of the medical, endoscopic and surgical management of GORD. Proton pump inhibitor
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Total neoadjuvant treatment for MRI-stratified high-risk rectal cancer: a single-center, single-arm, prospective Phase II trial (PKUCH-R02) Gastroenterol. Rep. (IF 3.6) Pub Date : 2023-04-18 Peng-Ju Chen, Lin Wang, Ting-Ting Sun, Yun-Feng Yao, Yi-Fan Peng, Jun Zhao, Tian-Cheng Zhan, Jia–Hua Leng, Yong Cai, Yong-Heng Li, Xiao-Yan Zhang, Ying-Shi Sun, Zhong-Wu Li, Wei-Hu Wang, Ai-Wen Wu
Background Induction chemotherapy combined with neoadjuvant chemoradiotherapy has been recommended for patients with high-risk, locally advanced rectal cancer. However, the benefit of more intensive total neoadjuvant treatment (TNT) is unknown. This study aimed to assess the safety and efficacy of induction chemotherapy combined with chemoradiotherapy and consolidation chemotherapy for magnetic resonance