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Feasibility and Safety of Endoscopic Control for Patients with Serrated Polyposis Syndrome. Dig. Dis. (IF 2.3) Pub Date : 2023-11-15 Michiko Nakaoka,Hideyuki Chiba,Mikio Kobayashi,Naoya Okada,Jun Arimoto,Jun Tachikawa,Keiichi Ashikari,Hiroki Kuwabara
INTRODUCTION Despite advances in endoscopic treatment, patients with serrated polyposis syndrome (SPS) occasionally require surgery due to numerous or unresectable polyps, recurrence, and treatment-related adverse events. METHODS We retrospectively evaluated 43 patients with SPS undergoing diagnosis and treatment at Omori Red Cross Hospital from 2011 to 2022. Resection of all polyps ≥ 3 mm in size
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Assessment of Internet Available Patient Information on Chronic Pancreatitis Using the Ensuring Quality Information for Patients Tool: A Systematic Search and Evaluation. Dig. Dis. (IF 2.3) Pub Date : 2023-11-13 Sebastian M Staubli,Shahi Ghani,Harriet Walker,Giuseppe K Fusai,Dimitri A Raptis
INTRODUCTION Chronic pancreatitis (CP) is a relevant chronic medical problem whereby delayed presentation and poor patient understanding can cause adverse effects. Quality of patient information available on the internet about CP is not known. METHODS A systematic review of the information about CP available online using the search term "chronic pancreatitis" in using the search engine Google has been
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Recent progress of image-enhanced endoscopy for upper gastrointestinal neoplasia and associated lesions. Dig. Dis. (IF 2.3) Pub Date : 2023-11-10 Yoshimasa Miura,Hiroyuki Osawa,Kentaro Sugano
BACKGROUND The main therapeutic modality of early upper gastrointestinal neoplasms has shifted from surgery to endoscopic therapy. The role of endoscopy has also expanded not only for more accurate diagnosis of neoplasms but for the determination of extent and depth of neoplasms with a combination of multiple electronically modified images acquired with image-enhanced endoscopy (IEE) for assessing
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A novel hemostatic peptide solution for common acute gastrointestinal bleeding diseases: First case series study on the treatment results of endoscopic hemostasis by non-expert endoscopists. Dig. Dis. (IF 2.3) Pub Date : 2023-11-10 Ai Fujimoto,Tsuyoshi Ishii,Tomomi Hiraoka,Yurie Ogawa,Nobuyuki Sato,Naoko Watanabe,Akira Nogami,Keita Soejima,Kodai Fujii,Aya Hojo,Ryo Shimizu,Yusuke Nishikawa,Nobuhiro Dan,Syunsuke Kobayashi,Yosuke Okamoto,Ryusuke Kimura,Kazuhisa Yamaguchi,Masashi Ono,Takahito Toba,Takahisa Matsuda
INTRODUCTION We investigated the hemostatic effect and safety of a hemostatic peptide solution for the treatment of gastrointestinal bleeding requiring emergency endoscopy. METHODS We retrospectively examined the patient backgrounds, hemostatic results, and procedural safety in patients who were treated with a hemostatic peptide solution for hemostasis during emergency endoscopies for gastrointestinal
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Proton Pump Inhibitor Use and Iron Deficiency Anemia in Celiac Patients. Dig. Dis. (IF 2.3) Pub Date : 2023-11-08 Stephanie Hawkins,Meghali Nighot,Shannon Dalessio,Junjia Zhu,Nathan Morris,Kofi Clarke
INTRODUCTION We sought to evaluate the effect of PPI (proton pump inhibitor) use on the development and severity of iron deficiency anemia (IDA) in celiac disease (CD). METHODS We conducted a retrospective chart review of patients older than 18 years of age at Milton S. Hershey Medical Center who were diagnosed with CD. We analyzed four cohorts of celiac patients (1) IDA diagnosis with PPI usage, (2)
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Review article: Thalidomide for the management of gastrointestinal bleeding in a palliative care setting. Dig. Dis. (IF 2.3) Pub Date : 2023-10-26 Elisabeth Fabian,Oliver Königsbrügge,Guenter J Krejs,Matthias Unseld
BACKGROUND Palliative care patients frequently present with cinically significant gastrointestinal bleeding. Due to the existence of confounding comorbidities and an often remarkably reduced state of general health, the management of gastrointestinal bleeding in this population is often challenging. SUMMARY This review summarises and discusses the role of thalidomide in gastrointestinal bleeding with
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Preoperative H. pylori eradication therapy facilitates precise delineation in early gastric cancer with current H. pylori infection. Dig. Dis. (IF 2.3) Pub Date : 2023-10-13 Zhiyu Yan,Long Zou,Qiang Wang,Shengyu Zhang,Yuhao Jiao,Dingkun Xiong,Qingwei Jiang,Tao Guo,Yunlu Feng,Dongsheng Wu,Yamin Lai,Xuemin Yan,Tao Xu,Weigang Fang,Xi Wu,Weixun Zhou,Aiming Yang
[Introduction] Early gastric cancer with current Helicobacter pylori infection (HpC-EGC) is common but still unclear whether H. pylori eradication therapy (Hp-ET) or endoscopic submucosal dissection (ESD) should be performed first. We evaluated Hp-ET's short-term effects on horizontal boundary delineations of HpC-EGC in ESD. [Methods] Prospectively enrolled HpC-EGC patients were randomly assigned to
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Onset time and characteristics of post-procedural bleeding after endoscopic resection of colorectal lesions: a multicenter retrospective study. Dig. Dis. (IF 2.3) Pub Date : 2023-10-09 Qiyun Xiao,Maximilian Eckardt,Awsan Mohamed,Helmut Ernst,Alexander Behrens,Nils Homann,Thomas Hielscher,Georg Kähler,Matthias Ebert,Sebastian Belle,Tianzuo Zhan
Introduction Postprocedural bleeding is a major adverse event after endoscopic resection of colorectal lesions, but the optimal surveillance time after endoscopy is unclear. In this study, we determined onset time and characteristics of postprocedural bleeding events. Methods We retrospectively screened patients who underwent endoscopic resection of colorectal lesions at three German hospitals between
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Comparison of outcomes between a basket catheter and a balloon catheter for endoscopic common bile duct stone removal. Dig. Dis. (IF 2.3) Pub Date : 2023-10-07 Hirokazu Saito,Hajime Iwasaki,Hisashi Itoshima,Yoshihiro Kadono,Takashi Shono,Kentaro Kamikawa,Atsushi Urata,Jiro Nasu,Masayoshi Uehara,Ikuo Matsushita,Tatsuyuki Kakuma,Shunpei Hashigo,Shuji Tada
BIntroduction: Evidence for the outcomes of endoscopic retrograde cholangiopancreatography (ERCP) between a basket catheter and a balloon catheter for endoscopic common bile duct stone (CBDS) removal is lacking. This study aimed to compare ERCP outcomes using a basket catheter and a balloon catheter for endoscopic CBDS removal. METHODS This multicenter retrospective study included 904 consecutive patients
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Developments in Gastroesophageal Reflux Disease over the Last 40 Years. Dig. Dis. (IF 2.3) Pub Date : 2023-09-29 Nimish Vakil
BACKGROUND The last 40 years have seen a remarkable change in our understanding of reflux disease. SUMMARY These changes encompass disease definition and impact, pathophysiology, diagnostic testing, regulatory oversight of clinical trials, pharmacotherapy, endoscopic, and surgical treatment. We have also seen a number of promising therapies fail. KEY MESSAGES The future holds the promise of further
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Metabolic dysfunction-associated fatty liver disease on distinct microbial communities at the bacterial phylum level. Dig. Dis. (IF 2.3) Pub Date : 2023-09-28 Haruki Uojima,Yoshihiko Sakaguchi,Kazuyoshi Gotoh,Takashi Satoh,Hisashi Hidaka,Akira Take,Kazue Horio,Shunji Hayashi,Chika Kusano
BACKGROUND Limited data are available on the correlation between microbial communities and metabolic dysfunction-associated fatty liver disease (MAFLD). OBJECTIVE This study aimed to evaluate the influence of MAFLD on distinct microbial communities. METHODS We recruited 43 patients with a nonviral liver disease. Enrolled patients were divided into two groups according to MAFLD criteria. The fecal microbial
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Considerations for Colorectal Neoplasia Detection in Inflammatory Bowel Disease Clinical Trials. Dig. Dis. (IF 2.3) Pub Date : 2023-09-27 Mira M Yang,Keith Usiskin,Harris A Ahmad,Shabana Ather,Antoine Sreih,James B Canavan,Francis A Farraye,Christopher Ma
BACKGROUND High-quality colonoscopic surveillance can lead to earlier and increased detection of colorectal neoplasia in patients with inflammatory bowel disease (IBD). In IBD clinical trials, endoscopy is used to assess mucosal disease activity before and after treatment, but also provides an opportunity to surveil for colorectal neoplasia during follow-up. SUMMARY Best practices for colorectal cancer
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Immunomodulatory role of mesenchymal stem cells in liver transplantation: status and prospects. Dig. Dis. (IF 2.3) Pub Date : 2023-09-20 Haitao Li,Saihua Yu,Lihong Chen,Hongzhi Liu,Conglong Shen
BACKGROUND Liver transplantation (LT) is the only effective therapy for end-stage liver diseases, but some patients usually present with serious infection and immune rejection. Those with immune rejection require long-term administration of immunosuppressants, leading to serious adverse effects. Mesenchymal stem cells (MSCs) have various advantages in immune regulation and are promising drugs most
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Menstrual status is associated with the prevalence of irritable bowel syndrome in a Japanese young population: A cross-sectional study. Dig. Dis. (IF 2.3) Pub Date : 2023-09-14 Shinya Furukawa,Yasunori Yamamoto,Teruki Miyake,Osamu Yoshida,Junichi Watanabe,Aki Kato,Katsunori Kusumoto,Eiji Takeshita,Yoshio Ikeda,Naofumi Yamamoto,Yuka Saeki,Yoichi Hiasa
INTRODUCTION There is evidence regarding the association between dysmenorrhea and irritable bowel syndrome (IBS), although it is lacking in the Asian population. Therefore, the purpose of this study was to investigate the association between menstrual status and IBS in a young Japanese. METHODS Overall, 4693 female college students were included in the analysis of this study. Information regarding
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Global Epidemiology of Cirrhosis: Changing Etiological Basis and Comparable Burden of NASH between Males and Females. Dig. Dis. (IF 2.3) Pub Date : 2023-09-13 Darren Tan,Kai En Chan,Zhen Yu Wong,Cheng Han Ng,Jieling Xiao,Wen Hui Lim,Phoebe Tay,Ansel Tang,Clarissa Elysia Fu,Mark Muthiah,Benjamin Nah,Eunice X Tan,Margaret L P Teng,Mohammad Shadab Siddiqui,Yock Young Dan,Seng Gee Lim,Rohit Loomba,Daniel Q Huang
INTRODUCTION The etiology of liver diseases has changed significantly, but its impact on the comparative burden of cirrhosis between males and females is unclear. We estimated sex differences in the burden of cirrhosis across 204 countries and territories from 2010-2019. METHODS We analyzed temporal trends in the burden of cirrhosis using the methodology framework of the 2019 Global Burden of Disease
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Management of the Rectal Stump after Subtotal Colectomy Operations for Inflammatory Bowel Disease in the Era of Immunologic Therapy: A Two-Centre Cohort Study. Dig. Dis. (IF 2.3) Pub Date : 2023-09-08 Dominika Boldovjakova,Islam El-Abbassy,Inari Alarcon,Mamoun El-Saify,Juen Hao Chan,Morag Harley,Craig Parnaby,Angus Watson,George Ramsay
INTRODUCTION Inflammatory bowel disease (IBD) often requires surgical resection, such as subtotal colectomy operations to alleviate symptoms. However, IBD also has an inherently increased risk of colorectal dysplasia and cancer. Despite the well-accepted surveillance guidelines for IBD patients with an intact colon, contemporaneous decision-making models on rectal stump surveillance is sparse. This
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Weekend effect on clinical outcomes of acute lower gastrointestinal bleeding: A large multicenter cohort study in Japan. Dig. Dis. (IF 2.3) Pub Date : 2023-09-05 Junnosuke Hayasaka,Daisuke Kikuchi,Naoki Ishii,Katsumasa Kobayashi,Atsushi Yamauchi,Atsuo Yamada,Jun Omori,Takashi Ikeya,Taiki Aoyama,Naoyuki Tominaga,Yoshinori Sato,Takaaki Kishino,Tsunaki Sawada,Masaki Murata,Akinari Takao,Kazuhiro Mizukami,Ken Kinjo,Shunji Fujimori,Takahiro Uotani,Minoru Fujita,Hiroki Sato,Sho Suzuki,Toshiaki Narasaka,Tomohiro Funabiki,Yuzuru Kinjo,Akira Mizuki,Shu Kiyotoki,Tatsuya
Introduction Weekend admissions showed increased mortality in several medical conditions. This study aimed to examine the weekend effect on acute lower gastrointestinal bleeding (ALGIB) and its mortality and other outcomes. Methods This retrospective cohort study (CODE BLUE-J Study) was conducted at 49 Japanese hospitals between January 2010 and December 2019. In total, 8120 outpatients with acute
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The Risk of Developing Disabling Crohn's Disease: Validation of a Clinical Prediction Rule to Improve Treatment Decision Making. Dig. Dis. (IF 2.3) Pub Date : 2023-08-23 Guillermo Bastida Paz,Olga Merino Ochoa,Mariam Aguas Peris,Manuel Barreiro-de Acosta,Yamile Zabana,Daniel Ginard Vicens,Daniel Ceballos Santos,Fernando Muñoz Núñez,David Monfort I Miquel,Ignacio Catalán-Serra,Valle García Sánchez,Carmen Loras Alastruey,Alfredo Lucendo Villarín,Jose Maria Huguet,Cristóbal de la Coba Ortiz,Xavier Aldeguer Manté,Antonio Palau Canós,Eugeni Domènech Morral,Pilar Nos,
BACKGROUND Crohn's disease (CD) is characterized by the development of complications over the course of the disease. It is crucial to identify predictive factors of disabling disease, in order to target patients for early intervention. We evaluated risk factors of disabling CD and developed a prognostic model. METHODS In total, 511 CD patients were retrospectively analyzed. Univariate and multivariate
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Liver Biopsy: To Do or Not to Do - A Single-Center Study. Dig. Dis. (IF 2.3) Pub Date : 2023-08-23 Theodoros Androutsakos,Konstantinos Dimitriadis,Konstantinos Revenas,Chrysovalantis Vergadis,Dimitrios-Dorotheos Papadakis,Stratigoula Sakellariou,Christos Vallilas,Gregorios Hatzis
INTRODUCTION A variety of liver disorders are associated with characteristic histopathological findings that help in their diagnosis and treatment. However, percutaneous liver biopsy (PLB) is prone to limitations and complications. We evaluated all PLBs done in our hospital in a 13-year period, aiming to assess PLB's utility and complications. METHODS All PLBs conducted in an internal medicine department
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Improved sleep affects epigastric pain in functional dyspepsia by reducing the levels of inflammatory mediators. Dig. Dis. (IF 2.3) Pub Date : 2023-08-22 Huang Du,Rongpan Lin,Shuping Xiao,Yu Zhao,Mingxia Wu,Wenhua Chen,Wangfeng Cai,Nating Wei,Guohua Gong,Kangming Huang,Fajing Zhang,Hongbin Chen
BACKGROUND The pathogenesis of epigastric pain in functional dyspepsia (FD) is complex. The study aims to explore the effect of sleep improvement on this symptom. METHODS In total, 120 patients with FD-associated epigastric pain and insomnia were randomly divided into experimental and control groups using the envelope method. After applying the exclusion criteria, 107 patients were enrolled in the
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The Characteristics and Treatment Outcomes of 71 Duodenal Brunner's Gland Adenomas with Endoscopic Submucosal Dissection. Dig. Dis. (IF 2.3) Pub Date : 2023-08-17 Ying Xiang,Jinyan Liu,Nan Ya Wang,Dehua Tang,Lei Wang,Ping Xiao Zou,Guifang Xu,Qin Huang
INTRODUCTION The aim of this study was to investigate outcomes of patients with duodenal Brunner's gland adenomas (BGAs) that were treated endoscopically. METHODS We identified 71 consecutive patients treated at our center with endoscopic submucosal dissection (ESD) for their duodenal tumors diagnosed pathologically as BGAs over the period between January 1, 2011 and December 31, 2021. We retrospectively
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IP10 and anti-HBc can predict virological relapse and HBsAg loss in chronic hepatitis B patients after nucleos(t)ide analogue discontinuation. Dig. Dis. (IF 2.3) Pub Date : 2023-08-16 Yandi Xie,Minghui Li,Xiaojuan Ou,Sujun Zheng,Yinjie Gao,Xiaoyuan Xu,Ying Yang,Anlin Ma,Jia Li,Yuemin Nan,Huanwei Zheng,Juan Liu,Lai Wei,Bo Feng
Introduction To assess predictive ability of serum interferon-inducible protein 10 (IP10) and hepatitis B core antibody (anti-HBc) levels for virological relapse (VR) and hepatitis B surface antigen (HBsAg) loss after nucleos(t)ide analogue (NA) discontinuation. Methods In this multicenter prospective study, overall 139 patients were followed up for 24 months after NA discontinuation. Results End of
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Use of Immunohistochemical p53 Mutant-Phenotype in Diagnosis of High-Grade Dysplasia of Esophageal Squamous Epithelia. Dig. Dis. (IF 2.3) Pub Date : 2023-08-14 Yan-Juan Xu,Ran Li,Jiang-Mu Chen,Xue-Yu Zhuang,Na Lin,Lin-Pei Wang,Bing-Wei Zeng
BACKGROUND Mild cellular atypia of esophageal squamous epithelial dysplasia has a risk of progressing to cancer that poses great confusion for pathological diagnosis. There is no research on the diagnosis and differential diagnosis of esophageal squamous dysplasia by the expression of immunohistochemical (IHC) p53. The study aims to conduct a graded diagnosis of esophageal squamous epithelial hyperplasia
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High systemic immune-inflammation index, predicting early allograft dysfunction, indicates high 90-day-mortality for acute-on-chronic liver failure after liver transplantation. Dig. Dis. (IF 2.3) Pub Date : 2023-07-26 Zongli Fu,Pengrui Cheng,Qian Jian,Hanyu Wang,Yi Ma
INTRODUCTION To investigate the relationship between systemic immune-inflammation index (SII) and early allograft dysfunction (EAD) and 90-day-mortality after liver transplantation (LT) in acute-on-chronic liver failure (ACLF). METHODS Retrospective records analysis was done on 114 patients who had LT for ACLF. To identify the ideal SII, the receiver operating characteristic (ROC) curve was used. The
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Can Frequent Toothbrushing Reduce the Risk of Cirrhosis among Patients with Non-alcoholic Fatty Liver Disease? Hints from a Registry-based Study. Dig. Dis. (IF 2.3) Pub Date : 2023-07-26 Caglayan Keklikkiran,Maria Stepanova,Zobair Younossi,Yusuf Yilmaz
INTRODUCTION While poor oral hygiene has been previously associated with an increased risk of non-alcoholic fatty liver disease (NAFLD), its association with hepatic fibrosis remains unclear. Here, we sought to analyze if toothbrushing frequency, an easy-to-assess indicator of oral health habits, would be associated with liver stiffness measurement (LSM) by transient elastography (TE) in patients with
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Adiponectin Levels in Inflammatory Bowel Disease - A Systematic Review and Meta-analysis. Dig. Dis. (IF 2.3) Pub Date : 2023-06-29 Teodora Surdea-Blaga,Abdulrahman Ismaiel,Ayman Jaaouani,Daniel Corneliu Leucuta,Abdalla Elsayed,Mohamed Ismaiel,Inès Ben Ameur,Nahlah Al Srouji,Stefan-Lucian Popa,Simona Grad,Dilara Ensar,Dan L Dumitrascu
INTRODUCTION Adipose tissue plays an important role in the pathogenesis of inflammatory conditions. The role of adipokines in inflammatory bowel disease (IBD) has been evaluated in the current literature with conflicting results. The aim of this study was to evaluate adiponectin levels in IBD patients, including Crohn's disease (CD) and ulcerative colitis (UC), compared to controls, as well as further
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Interstitial brachytherapy for hepatocellular carcinoma: Analysis of prognostic factors for overall survival and progression free survival and application of a risk stratification model. Dig. Dis. (IF 2.3) Pub Date : 2023-06-29 Maximilian Thormann,Franziska Heitmann,Vanessa Wrobel,Constanze Heinze,Christine March,Peter Hass,Robert Damm,Alexey Surov,Maciej Pech,Jazan Omari
Introduction Interstitial brachytherapy (iBT) is an effective treatment for hepatocellular carcinoma (HCC). Identification of prognostic factors is pivotal for patient selection and treatment efficacy. This study aimed to assess the impact of low skeletal muscle mass (LSMM) on overall survival (OS) and progression free survival (PFS) of iBT in patients with HCC. Methods For this single-center study
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Long-Term Prognosis and Related Factors in Patients with Cirrhosis Treated with Balloon-Occluded Retrograde Transvenous Obliteration. Dig. Dis. (IF 2.3) Pub Date : 2023-06-29 Yamato Tamura,Yoshinari Asaoka,Akihito Takeuchi,Kosuke Matsumoto,Ryo Miura,Koichiro Abe,Toshihiko Arizumi,Masayoshi Yamamoto,Shinya Kodashima,Hiroshi Kondo,Takatsugu Yamamoto,Atsushi Tanaka
INTRODUCTION Balloon-occluded retrograde transvenous obliteration (BRTO) was developed as an effective treatment for gastric varices in patients with cirrhosis. Because liver fibrosis in these patients is assumed to be advanced, their prognosis is expected to be poor. In this study, we investigated the prognosis and characteristics of the patients. METHODS We enrolled 55 consecutive patients with liver
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Effectiveness of Water-Assisted Colonoscopy without Sedation in Patients with Ulcerative Colitis. Dig. Dis. (IF 2.3) Pub Date : 2023-06-27 Haitao Shi,Hong Zeng,Mei Wang,Jiong Jiang,Sumei Sha,Fenrong Chen,Yan Wang,Yan Cheng,Shiyang Ma,Xin Liu
BACKGROUND Studies have found that water-assisted colonoscopy (WAC) including water immersion colonoscopy (WIC) and water exchange colonoscopy (WEC) is superior to air insufflation colonoscopy (AIC) in terms of the cecal intubation rate. However, the application of WAC in ulcerative colitis (UC) has rarely been reported. This study aimed to explore the effectiveness of WAC without sedation in patients
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Efficacy of Co-Medications in Patients with Alcoholic Liver Disease. Dig. Dis. (IF 2.3) Pub Date : 2023-06-26 Timo Itzel,Thomas Falconer,Ana Roig,Jimmy Daza,Jimyung Park,Jae Youn Cheong,Rae Woong Park,Isabella Wiest,Matthias P Ebert,George Hripcsak,Andreas Teufel
BACKGROUND Alcoholic liver disease (ALD) is still increasing and leads to acute liver injury but also liver cirrhosis and subsequent complications such as liver failure or hepatocellular carcinoma (HCC). As most patients fail to achieve alcohol abstinence, it is essential to identify alternative treatment options in order to improve the outcome of ALD patients. METHODS Evaluating two large cohorts
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The Albumin-Bilirubin Score as a Predictor of Liver-Related Mortality in Primary Biliary Cholangitis with Compensated Cirrhosis. Dig. Dis. (IF 2.3) Pub Date : 2023-06-15 Qingling Chen,Rui Zhong,Yao Wang,Yiwen Kui,Xiaoyu Wen,Jianjie Huang,Qinglong Jin
INTRODUCTION Although several prognostic scores have been reported to correlate with the prognosis of primary biliary cholangitis (PBC) patients, there are limited tools to predict the prognosis of PBC with compensated cirrhosis. This study aimed to evaluate the prognostic performance of the albumin-bilirubin (ALBI) score in PBC patients with compensated cirrhosis. METHODS We conducted a retrospective
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Barrett's Esophagus in Eosinophilic Esophagitis in Swiss Eosinophilic Esophagitis Cohort Study (SEECS). Dig. Dis. (IF 2.3) Pub Date : 2023-05-24 Roger Scherer,Philipp Schreiner,Jean-Benoit Rossel,Thomas Greuter,Emanuel Burri,Catherine Saner,Christoph Schlag,Ekaterina Safroneeva,Alain Schoepfer,Alex Straumann,Luc Biedermann,
INTRODUCTION There is a complex interrelationship between gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EoE) potentially promoting the occurrence and modulating severity of each other reciprocally. Presence of Barrett's esophagus (BE) is a defining factor for the diagnosis of GERD. While several studies investigated the potential impact of concomitant GERD on the presentation
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Metachronous Multiple Gastric Cancer Discovered as Endoscopic Curability C2 during Regular Follow-Up after Gastric Endoscopic Submucosal Dissection. Dig. Dis. (IF 2.3) Pub Date : 2023-05-15 Kosuke Nomura,Shu Hoteya,Daisuke Kikuchi,Yusuke Kawai,Yorinari Ochiai,Takayuki Okamura,Yugo Suzuki,Junnosuke Hayasaka,Yutaka Mitsunaga,Masami Tanaka,Kazuhiro Fuchinoue,Hiroyuki Odagiri,Satoshi Yamashita,Akira Matsui
INTRODUCTION The objective of this study was to clarify characteristics of metachronous endoscopic curability C2 (eCura C2) cancer during post-endoscopic submucosal dissection (ESD) follow-up. METHODS Of 4,355 gastric lesions treated by ESD at our hospital during 2005-2021, 657 were metachronous. After excluding lesions found ≥2 years since the prior examination or in the gastric remnant, the remaining
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Safety of Cold Snare Polypectomy during Continuous Use of Antithrombotic Drugs for Delayed Post-Polypectomy Bleeding: A Pilot Study. Dig. Dis. (IF 2.3) Pub Date : 2023-05-15 Junnosuke Hayasaka,Satoshi Yamashita,Akira Matsui,Yusuke Kawai,Yorinari Ochiai,Takayuki Okamura,Yugo Suzuki,Yutaka Mitsunaga,Kosuke Nomura,Masami Tanaka,Kazuhiro Fuchinoue,Hiroyuki Odagiri,Daisuke Kikuchi,Yutaka Takazawa,Shu Hoteya
BACKGROUND Cold snare polypectomy is a high-risk endoscopic procedure with a low delayed post-polypectomy bleeding rate. However, it is unclear whether delayed post-polypectomy bleeding rates increase during continuous antithrombotic treatment. This study aimed to determine the safety of cold snare polypectomy during continuous antithrombotic treatment. METHODS This single-center, retrospective cohort
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The Day-To-Day Practice of MMR and MSI Assessment in Colorectal Adenocarcinoma: What We Know and What We Still Need to Explore. Dig. Dis. (IF 2.3) Pub Date : 2023-05-15 Paola Parente,Federica Grillo,Alessandro Vanoli,Maria Cristina Macciomei,Maria Raffaella Ambrosio,Nunzia Scibetta,Emanuela Filippi,Ivana Cataldo,Luigi Baron,Giuseppe Ingravallo,Gerardo Cazzato,Laura Melocchi,Barbara Liserre,Carla Giordano,Graziana Arborea,Emanuela Pilozzi,Antonio Scapinello,Maria Costanza Aquilano,Roberta Gafà,Serena Battista,Luca Dal Santo,Michela Campora,Francesco Giuseppe Carbone
BACKGROUND The DNA mismatch repair (MMR) system is a highly preserved protein complex recognizing short insertions, short deletions, and single base mismatches during DNA replication and recombination. MMR protein status is identified using immunohistochemistry. Deficit in one or more MMR proteins, configuring deficient MMR status (dMMR), leads to frameshift mutations particularly clustered in microsatellite
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Quality Assessment of Ultrasound and Magnetic Resonance Imaging for Hepatocellular Carcinoma Surveillance: A Systematic Review and Meta-Analysis. Dig. Dis. (IF 2.3) Pub Date : 2023-05-11 Jingxuan Quek,Darren Jun Hao Tan,Kai En Chan,Wen Hui Lim,Cheng Han Ng,Yi Ping Ren,Teng Kiat Koh,Readon Teh,Jieling Xiao,Clarissa Fu,Nicholas Syn,Margaret Teng,Mark Muthiah,Kathryn J Fowler,Claude B Sirlin,Rohit Loomba,Daniel Q Huang
INTRODUCTION To achieve early detection and curative treatment options, surveillance imaging for hepatocellular carcinoma (HCC) must remain of quality and without substantial limitations in liver visualization. However, the prevalence of limited liver visualization during HCC surveillance imaging has not been systematically assessed. Utilizing a systematic review and meta-analytic approach, we aimed
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Evaluation and Validation of a New Score to Measure the Severity of Small Bowel Angiodysplasia on Video Capsule Endoscopy. Dig. Dis. (IF 2.3) Pub Date : 2023-04-11 Tiago Capela, Tiago Cúrdia Gonçalves, Bruno Rosa, José Cotter
It's not mentioned in author guidelines' section that is mandatory to write an abstract for a letter to the editor.
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Gastroduodenal ulcers in liver transplant recipients under immunosuppressive therapy Dig. Dis. (IF 2.3) Pub Date : 2023-04-05 Kozue Kakizoe, Takehiro Torisu, Yutaro Ihara, Noboru Harada, Tomoharu Yoshizumi, Shin Fujioka, Masahiro Kondo, Takanari Kitazono
Abstract Introduction The proportion of gastroduodenal ulcers caused by drugs is increasing. However, the risk of gastroduodenal ulcer from drugs other than non-steroidal anti-inflammatory drugs (NSAIDs) and low-dose aspirin (LDA) is unclear. An association between immunosuppressive drugs and gastroduodenal ulcers has been suggested. We aimed to identify the immunosuppressive drugs and clinical characteristics
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Anemia is associated with disease severity, hepatic complications, and progression of Wilson disease: a retrospective cohort study Dig. Dis. (IF 2.3) Pub Date : 2023-04-05 Si-Qi Wang, Yong-Qiang Zhan, Xuan Hu, Yu-Pei Zhuang, Hong-Qian Liu, Ming-Fan Hong, Hao-Jie Zhong
Introduction: Anemia is a common manifestation of chronic liver diseases. It is a predictor of severe disease, a high risk of complications, and poor outcomes in various liver diseases. However, it remains unclear whether anemia serves as a similar indicator in patients with Wilson disease (WD). Therefore, this study aimed to investigate the relationship between anemia and severity, hepatic complications
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Early predictors of infected pancreatic necrosis in acute severe pancreatitis – Implications of neutrophil to lymphocyte ratio, blood procalcitonin concentration and modified CT severity index Dig. Dis. (IF 2.3) Pub Date : 2023-03-30 Qing-Yun Zhu, Ruo-Meng Li, Yun-Peng Zhu, Dong-Liang Hao, Yan Liu, Jing Yu, Xue Yang, Yu-Shi Zhang, Tian-Jiao Lin, Xu Yan, Jian-Xin Zuo, Xin-Ting Pan
Background: Infected pancreatic necrosis (IPN) accounts for 30% mortality in severe acute pancreatitis (SAP). Early prediction of IPN occurrence is critical for prophylactic measures to be taken. This study aimed to evaluate the predicting value for IPN of combined markers at early stages of SAP. Methods: The clincial records of 324 SAP patients admitted within 48 hours after disease onset were retrospectively
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Factors related to difficulty in endoscopic submucosal dissection for superficial esophageal cancer Dig. Dis. (IF 2.3) Pub Date : 2023-03-29 Yasuhiko Hamada, Kyosuke Tanaka, Masaki Katsurahara, Noriyuki Horiki, Yuhei Umeda, Yohei Ikenoyama, Hiroki Yukimoto, Junya Tsuboi, Reiko Yamada, Misaki Nakamura, Hayato Nakagawa
Introduction: Endoscopic submucosal dissection (ESD) for superficial esophageal cancer is technically challenging, and research on predictive factors related to the difficulty in the procedure is limited. This study aimed to investigate the factors predicting the difficulty in esophageal ESD. Methods: This retrospective study analyzed 303 lesions treated at our institution between April 2005 and June
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Uncovering the Silent Killer: Research highlights on chronic liver diseases Dig. Dis. (IF 2.3) Pub Date : 2023-03-28 Yao-Chun Hsu
Chronic liver disease (CLD) affects approximately 1.5 billion people around the world.1 Non-alcoholic fatty liver disease (NAFLD) is the most common CLD that accounts for 59% of prevalent cases, followed by hepatitis B virus (HBV) infection (29%) and hepatitis C virus infection (9%).2 CLD is a silent killer characterized by insidious progression in hepatic necroinflammation and fibrosis that can culminate
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Insights from an exploratory retrospective cohort study: Are face-to-face follow-up consultations after colonoscopy a thing of the past Dig. Dis. (IF 2.3) Pub Date : 2023-03-24 Jerrald Lau, Ning-Qi Pang, Chermaine Ang, Ker-Kan Tan
Background Colonoscopy is a commonly performed procedure but most patients will not actually be found with colorectal cancer. Subsequent face-to-face consultations to explain post-colonoscopy findings are common despite the time and cost-saving benefits of teleconsultation, especially in a post-COVID-19 era. This exploratory retrospective study examined the proportion of post-colonoscopy follow-up
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Characteristics and Outcomes of Elderly Hepatocellular Carcinoma Patients following Surgical Resection: Systematic Review and Meta-analysis Dig. Dis. (IF 2.3) Pub Date : 2023-03-13 Elizabeth M Garcia, Sanjna N Nerurkar, Eunice X Tan, Shaun YS Tan, Ern-Wei Peck, Sabrina XZ Quek, Readon Teh, Margaret Teng, Andrew Tran, Ee Jin Yeo, Michael Le, Connie Wong, Ramsey Cheung, Daniel Q. Huang
Background Aims: Due to ageing of the global population, hepatocellular carcinoma (HCC) is increasingly common among elderly patients, but outcomes after curative hepatic resection are unclear. Using a metanalytic approach, we aimed to estimate overall survival (OS), recurrence free survival (RFS) and complication rates in elderly HCC patients undergoing resection. Methods: We searched PubMed, Embase
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Helicobacter pylori infection as predictor of treatment outcomes of gastric cancer: a systematic review and metanalysis Dig. Dis. (IF 2.3) Pub Date : 2023-03-10 Chenxiao Gan, Xueping Wu, Yu Shen, Zhongsheng Cao, Jiyong Ji, Wensheng Pan
Background: Helicobacter pylori infection is strongly associated with gastric cancer. However, there is currently no consensus on the association between H. pylori and gastric cancer prognosis. Methods: A systematic search was conducted on studies in PubMed, EMBASE, and Web of Science up to March 10, 2022. The quality of all included studies was assessed using the Newcastle-Ottawa Scale. The hazard
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Therapeutic Plasma Exchange in ICU patients with acute hypertriglyceridemia-induced pancreatitis improves patient outcomes Dig. Dis. (IF 2.3) Pub Date : 2023-03-04
Background: Acute severe pancreatitis is associated with high morbidity and mortality. Hypertriglyceridemia is the third most common cause of acute pancreatitis and higher triglyceride levels increase the risk for severe acute pancreatitis. Plasma exchange is an effective treatment method to lower triglycerides. Our study aimed to investigate the efficiency of plasma exchange as a treatment option
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The Role of Fecal Microbiota Transplantation in the Induction of Remission in Ulcerative Colitis Dig. Dis. (IF 2.3) Pub Date : 2023-03-01 Adam Saleh, Shyon Parsa, Manuel Garza, Eamonn M.M. Quigley, Bincy P. Abraham
Background: Considerable research supports an important role for the microbiome and/or microbiome–host immune system interactions in the pathogenesis of inflammatory bowel disease (IBD). Consequently, microbiota-modulating interventions, such as fecal microbiota transplantation (FMT), have attracted interest in the management of IBD, including ulcerative colitis (UC). Summary: While the clinical response
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High visceral-to-subcutaneous fat ratio is associated with an increased risk of gastroesophageal reflux disease in non-obese adults Dig. Dis. (IF 2.3) Pub Date : 2023-02-24 Ja Eun Koo, Hye-Sook Chang, Hye Won Park, Sungwon Park, Inyoung Bae, Ji Young Lee, Jaewon Choe
Background: Abdominal obesity increases the risk of gastroesophageal reflux disease (GERD). This study aimed to determine the association between GERD and abdominal fat area quantified by computed tomography (CT). Methods: We analyzed the effect of abdominal fat area on gastroesophageal reflux symptoms and erosive esophagitis using logistic regression models in 5,338 participants who underwent abdominal
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Diagnostic value of serum Golgi protein 73 for liver fibrosis: a systematic review and meta-analysis Dig. Dis. (IF 2.3) Pub Date : 2023-02-22 Se Peng, Qingrong Wu, Xiaoting Huang, Xuehua He, Zhong Li, Jianfeng Xu, Lei Wang, Jialing Zhuang
Background: The assessment of liver fibrosis has been a critical component in the clinical management of liver diseases. We performed a meta-analysis to evaluate serum Golgi protein 73 (GP73) in the diagnosis of liver fibrosis. Methods: A literature search was performed in eight databases until July 13, 2022. We searched strictly studies according to inclusion and exclusion criteria, extracted data
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Long-term outcomes of endoscopic submucosal dissection for special type of esophageal cancer Dig. Dis. (IF 2.3) Pub Date : 2023-02-09
Introduction: Esophageal cancers other than two types, squamous cell carcinoma (SCC) and adenocarcinoma, are commonly referred to as special type of esophageal cancer (STEC). Studies on STECs have been limited because of its low prevalence. Therefore, we aimed to clarify the clinicopathological findings and the long-term outcomes of STECs that were managed with ESD. Methods: We reviewed 713 patients
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Long-Term Outcomes of Endoscopic Submucosal Dissection for Special Type of Esophageal Cancer. Dig. Dis. (IF 2.3) Pub Date : 2023-02-09 Yugo Suzuki,Kosuke Nomura,Akira Matsui,Daisuke Kikuchi,Kenichi Ohashi,Shu Hoteya
BACKGROUND Esophageal cancers other than two types, squamous cell carcinoma (SCC) and adenocarcinoma, are commonly referred to as special type of esophageal cancer (STEC). Studies on STECs have been limited because of its low prevalence. Therefore, we aimed to clarify the clinicopathological findings and the long-term outcomes of STECs that were managed with ESD. METHODS We reviewed 713 patients with
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Efficacy of a gastroscope for cecal intubation during colonoscopy in patients with severe sigmoid adhesion Dig. Dis. (IF 2.3) Pub Date : 2023-02-03 Jun Takada, Yukari Uno, Koji Yamashita, Masamichi Arao, Masaya Kubota, Takashi Ibuka, Hiroshi Araki, Masahito Shimizu
Background: Cecal intubation during colonoscopy is difficult to achieve in patients with severe sigmoid adhesions. This retrospective observational study assessed the efficacy of using a gastroscope for colonoscopy in patients with severe sigmoid adhesions. Furthermore, the ability of computed tomography (CT) to predict the possibility of cecal intubation using a gastroscope was examined. Methods:
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Incomplete Intestinal Metaplasia is Rare in Autoimmune Gastritis Dig. Dis. (IF 2.3) Pub Date : 2023-02-03 Robert M. Genta, Kevin O Turner, Cristian Robiou, Anuradha Singhal, Massimo Rugge
Background: Incomplete intestinal metaplasia (IM) is reportedly associated with higher gastric cancer (GC) risk than its complete variant. AGA Guidelines recommend including IM subtyping in routine pathology reports. This study assesses the prevalence of complete versus incomplete IM in gastric conditions with different GC risks. Methods: IM-subtyping (complete versus incomplete) and grading (IM extension:
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Body composition predictors of complicated Crohn’s disease Dig. Dis. (IF 2.3) Pub Date : 2023-01-31 Felix Barajas Ordonez, Bohdan Melekh, Pablo Rodríguez-Feria, Oksana Melekh, Maximilian Thormann, Robert Damm, Jazan Omari, Maciej Pech, Alexey Surov
Background: High visceral adipose tissue (VAT) and creeping fat (CrF) in Crohn's disease (CD) have been widely recognized. The VAT to subcutaneous adipose tissue (SAT) ratio and sarcopenia have been associated with CD complications. Studies regarding the influence of body composition predictors on CD complications assessed with magnetic resonance enterography (MRE) are scarce. Aim: Assessment of the
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EFFICACY, EFFICIENCY, AND ACCEPTABILITY OF TELEMEDICINE FOR INFLAMMATORY BOWEL DISEASE PATIENTS FOLLOW-UP CARE DURING THE COVID-19 PANDEMIC. Dig. Dis. (IF 2.3) Pub Date : 2023-01-30 Laura Ramos, Cristina Reygosa, Marta Carrillo-Palau, Inmaculada Alonso-Abreu, Yanira González-Méndez, Raquel De la Barreda, Carla Amaral, Anjara Hernández, Federica Benítez-Zafra, Manuel Hernández-Guerra
Background: During the COVID-19 pandemic, ambulatory clinic visits were replaced by the implementation of telehealth modalities in most IBD units. Aims: To assess the efficacy, efficiency, patient satisfaction, and acceptability of using telephone consultation in an IBD unit. Methods: A prospective cohort study was performed in IBD patients who underwent telephone consultation during COVID-19 lockdown
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High accuracy of a simplified, practical algorithm in differentiating Crohn's Disease from Intestinal Tuberculosis Dig. Dis. (IF 2.3) Pub Date : 2023-01-26
Background: The differentiation between intestinal tuberculosis from Crohn's disease remains a challenge, particularly in areas where tuberculosis is highly prevalent. Previous studies have identified features that favor one diagnosis over the other. To determine the accuracy of a standardized protocol in the initial diagnosis of Crohn’s disease versus intestinal tuberculosis. Methods: All patients
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One-day versus three-day low residue diet and bowel preparation quality before colonoscopy: a multicenter, randomized, controlled trial Dig. Dis. (IF 2.3) Pub Date : 2023-01-17
Background One-day low residue diet (LRD) is recommended before colonoscopy, but only three single center trials compared the 1-day vs 3-days LRD. The aim of this multicenter study was to compare the impact of a 3-days vs 1-day LRD on its ability to adequately and successfully prepare the bowel of outpatients that require a colonoscopy. The outpatients' tolerance and adherence to the LRD were also
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Is the current Maastricht consensus report applicable for H. pylori management in Sub-Saharan Africa? Dig. Dis. (IF 2.3) Pub Date : 2023-01-17 Mashiko Setshedi
Helicobacter infection is highly prevalent in Africa, and its diagnosis, treatment and complications pose significant challenges particularly in Sub-Saharan Africa (SSA). While the new Maastricht VI/Florence consensus report offer much-awaited guidelines in the various aspects of the management of H. pylori, they also highlight some of the unique challenges that we face in SSA in adequately managing
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Clinical outcomes of Medical management options for chronic anal fissures in a long term follow up: systematic review and meta-analysis Dig. Dis. (IF 2.3) Pub Date : 2023-01-16 Fernando Sierra-Arango, José De la Hoz-Valle, Juan Pablo Espinosa, José Moreno-Montoya, Mariana Vásquez Roldan, Erika D. Pérez-Riveros
Background: Topical treatments and botulinum toxin injections are valid options for the management of patients with chronic anal fissures (CAF) but little is known about the efficacy in a long-term follow-up. The aim of this meta-analysis was evaluate the effectiveness, given to clinical outcomes of medical treatments in adults. Method: this manuscript was developed according to PRISMA [23, 25] and
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Liver transplantation after successful downstaging of a locally advanced hepatocellular carcinoma with systemic therapy Dig. Dis. (IF 2.3) Pub Date : 2023-01-16 Andreas Schmiderer, Heinz Zoller, Markus Niederreiter, Maria Effenberger, Georg Oberhuber, Felix Julius Krendl, Rupert Oberhuber, Stefan Schneeberger, Herbert Tilg, Angela Djanani
Introduction: Liver transplantation (LT) is potentially curative for patients with cirrhosis and hepatocellular carcinoma (HCC). However, this procedure is usually reserved for patients with early tumor stages or after successful downstaging with local regional therapies (LRT). In patients with locally advanced HCC current guidelines recommend locoregional and palliative systemic therapies for tumor