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Arrhythmia Burden Among Adult Patients With Congenital Heart Disease: A Population‐Based Study J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-17 Nili Schamroth Pravda, Ofra Kalter‐Leibovici, Amiram Nir, Avraham Lorber, Alexander Dadashev, Rafael Hirsch, Michal Benderly, for the Israeli Congenital Heart Disease Research Group
BackgroundA significant percentage of patients with congenital heart disease surviving into adulthood will develop arrhythmias. These arrhythmias are associated with an increased risk of adverse events and death. We aimed to assess arrhythmia prevalence, risk factors, and associated health care usage in a large national cohort of patients with adult congenital heart disease.Methods and ResultsAdults
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Tempering the Storm of Arrhythmias in Adults With Congenital Heart Disease J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-17 Edward O'Leary, Anne Marie Valente, Thomas Tadros
According to the National Weather Service, a thunderstorm lifecycle typically progresses through 3 stages: (1) a developing stage, marked by updrafts of moist air with no precipitation but perhaps lightning; (2) a mature stage, whereby precipitation, lightning, and wind gusts manifest and are balanced by ongoing updrafts; and (3) a dissipating stage, consisting of a shift from updrafts to downdrafts
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Longitudinal Analysis of the Relationship Between Social Isolation and Hypertension in Early Middle Adulthood J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-15 Marie Parker, Shannon Renee Self‐Brown, Ali Rahimi, Xiangming Fang
BackgroundMost studies have used cross‐sectional or limited follow‐up data to evaluate the relationship between social isolation (SI) and hypertension in older populations. The objective of this analysis was to examine the relationship between longitudinal SI and hypertension in a younger population.Methods and ResultsThe present analysis used data from waves I to V of the National Longitudinal Study
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Anticoagulation for Patients With Concomitant Atrial Fibrillation and End‐Stage Renal Disease: A Systematic Review and Network Meta‐Analysis J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-12 Ting‐Wei Kao, Zheng‐Wei Chen, Yen‐Hung Lin
BackgroundConcomitant atrial fibrillation and end‐stage renal disease is common and associated with an unfavorable prognosis. Although oral anticoagulants have been well established to prevent thromboembolism, the applicability in patients under long‐term dialysis remains debatable. The study aimed to determine the efficacy and safety of anticoagulation in the dialysis‐dependent population.Methods
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Hypothermic Oxygenated Perfusion Improves Vascular and Contractile Function by Preserving Endothelial Nitric Oxide Production in Cardiac Grafts Obtained With Donation After Circulatory Death J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-12 Manuel Egle, Natalia Mendez‐Carmona, Adrian Segiser, Selianne Graf, Matthias Siepe, Sarah Longnus
BackgroundCardiac donation after circulatory death is a promising option to increase graft availability. Graft preservation with 30 minutes of hypothermic oxygenated perfusion (HOPE) before normothermic machine perfusion may improve cardiac recovery as compared with cold static storage, the current clinical standard. We investigated the role of preserved nitric oxide synthase activity during HOPE on
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A Comparison of 5 Measures of Accelerated Biological Aging and Their Association With Incident Cardiovascular Disease: The CARDIA Study J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-12 Sarah N. Forrester, Jonggyu Baek, Lifang Hou, Veronique Roger, Catarina I. Kiefe
BackgroundAccelerated biological aging is an increasingly popular way to track the acceleration of biology over time that may not be captured by calendar time. Biological aging has been linked to external and internal chronic stressors and has the potential to be used clinically to understand a person's personalized functioning and predict future disease. We compared the association of different measures
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Temporal Trends in Cardiovascular Disease Prevalence Among Asian American Subgroups J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-12 Kaylin T. Nguyen, Jiang Li, Allison W. Peng, Kristen Azar, Paul Heidenreich, Latha Palaniappan, Celina M. Yong
BackgroundAsian and multiracial individuals represent the 2 fastest growing racial and ethnic groups in the United States, yet most prior studies report Asian American and Native Hawaiian or Other Pacific Islander as a single racial group, with limited data on cardiovascular disease (CVD) prevalence among subgroups. We sought to evaluate temporal trends in CVD burden among disaggregated Asian subgroups
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Conflicts of Interest Among Cardiology Clinical Practice Guideline Authors in Japan J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-12 Anju Murayama, Megumi Aizawa, Keerthana R. Byreddy, Kenichi Higuchi, Yuki Senoo
BackgroundClinical practice guidelines (CPGs) offer disease management recommendations based on scientific evidence. However, financial conflicts of interest between CPG developers and the pharmaceutical industry could bias these recommendations, potentially affecting patient care. Proper management of these conflicts of interest is particularly crucial for maintaining the integrity of CPGs. The study
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Cost‐Effectiveness of a Multicomponent Primary Care Intervention for Hypertension J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-12 Junxing Chay, Tazeen H. Jafar, Rebecca J. Su, Rupesh M. Shirore, Ngiap Chuan Tan, Eric A. Finkelstein
BackgroundThe SingHypertension primary care clinic intervention, which consisted of clinician training in hypertension management, subsidized single‐pill combination medications, nurse‐delivered motivational conversations and telephone follow‐ups, improved blood pressure control and cardiovascular disease (CVD) risk scores relative to usual care among patients with uncontrolled hypertension in Singapore
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Cardiovascular Risk in Patients With Treated Isolated Diastolic Hypertension and Isolated Low Diastolic Blood Pressure J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-12 Wei‐Lun Chang, Ying‐Fan Chen, Yu‐Hsuan Lee, Ming‐Neng Shiu, Po‐Yin Chang, Chao‐Yu Guo, Chi‐Jung Huang, Chern‐En Chiang, Chen‐Huan Chen, Shao‐Yuan Chuang, Hao‐Min Cheng
BackgroundThe prognosis of high or markedly low diastolic blood pressure (DBP) with normalized on‐treatment systolic blood pressure on major adverse cardiovascular events (MACEs) is uncertain. This study examined whether treated isolated diastolic hypertension (IDH) and treated isolated low DBP (ILDBP) were associated with MACEs in patients with hypertension.Methods and ResultsA total of 7582 patients
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Factors Associated With Premature Termination of Hyperacute Stroke Trials: A Review J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-12 Yasmin N. Aziz, Heidi Sucharew, Mathew J. Reeves, Joseph P. Broderick
BackgroundWe performed a review of acute stroke trials to determine features associated with premature termination of trial enrollment, defined by the authors as not meeting preplanned sample size.Methods and ResultsMEDLINE was searched for randomized clinical stroke trials published in 9 major clinical journals between 2013 and 2022. We included randomized clinical trials that were phase 2 or 3 with
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Prognostic Implication of Right Ventricular Free Wall Longitudinal Strain and Right Atrial Pressure Estimated By Echocardiography in Patients With Severe Functional Tricuspid Regurgitation J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-12 Mana Ogawa, Ken Kuwajima, Takafumi Yamane, Hiroko Hasegawa, Nobuichiro Yagi, Takahiro Shiota
BackgroundThe interaction between right ventricular (RV) function and pulmonary hypertension is crucial for prognosis of patients with severe functional tricuspid regurgitation. RV free wall longitudinal strain (RVFWLS) has been reported to detect RV systolic dysfunction earlier than other conventional parameters. Although pulmonary artery systolic pressure measured by Doppler echocardiography is often
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Reversion of the Inflammatory Markers in Patients With Chronic Limb‐Threatening Ischemia J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-12 Joana Ferreira, Susana Roque, Alexandre Lima Carneiro, Adhemar Longatto‐Filho, Isabel VilaNurse, Cristina Cunha, Cristina Silva, Amílcar Mesquita, Jorge Cotter, Margarida Correia‐Neves, Armando Mansilha, Pedro Guimarães Cunha
BackgroundPeripheral artery disease is characterized by an intense inflammatory process that can be associated with a higher mortality rate, particularly in chronic limb‐threatening ischemia (CLTI). This study aims to compare the evolution of inflammatory markers between patients with claudication with those with CLTI at 3, 6, and 12 months.Methods and ResultsAn observational, single‐center, and prospective
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Cardiovascular Disease Screening in homeless: A Feasibility Study J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-12 Julian Surey, Martha Veitch, Sally Rogers, Nader Al Shakarchi, Stan Burridge, Mark Leonard, Sophie Munday, Alistair Story, Amitava Banerjee
The pandemic and cost‐of‐living crises across countries make homelessness a greater challenge to individuals, populations, and health systems. Cardiovascular disease (CVD) risk and burden are higher in homeless than those who are housed. A UK study in homeless (n=8492) versus housed showed higher rates of smoking, atrial fibrillation, and CVD (11.6% versus 6.5%) and incidence (14.7 versus 8.1 per 1000
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Periodontal Treatment During the Blanking Period Improves the Outcome of Atrial Fibrillation Ablation J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-10 Shunsuke Miyauchi, Kazuhisa Ouhara, Tomoaki Shintani, Takehito Tokuyama, Yousaku Okubo, Sho Okamura, Shogo Miyamoto, Naoto Oguri, Yukimi Uotani, Tasuku Takemura, Misako Tari, Toru Hiyama, Mutsumi Miyauchi, Mikihito Kajiya, Noriyoshi Mizuno, Yukiko Nakano
BackgroundPeriodontitis has not been recognized as a modifiable risk factor for atrial fibrillation (AF). This prospective nonrandomized study investigated whether periodontal treatment improves the AF ablation outcome.Methods and ResultsWe prospectively enrolled 288 AF patients scheduled to undergo initial radiofrequency catheter ablation. Each patient underwent periodontal inflamed surface area (PISA;
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Sodium Glucose Transporter 2 Inhibitors Versus Metformin on Cardiovascular and Renal Outcomes in Patients With Diabetes With Low Cardiovascular Risk: A Nationwide Cohort Study J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-09 Hao‐Chih Chang, Yun‐Yu Chen, Tzu‐Ting Kuo, Yenn‐Jiang Lin, Kuo‐Liong Chien, Hung‐Yu Chang, Chung‐Lieh Hung, Fa‐Po Chung
BackgroundThis study investigated whether initial SGLT2 (sodium‐glucose cotransporter 2) inhibitor‐based treatment is superior to metformin‐based regimens as a primary prevention strategy among low‐risk patients with diabetes.Methods and ResultsIn this nationwide cohort study, a total of 38 496 patients with diabetes with low cardiovascular risk were identified (age 62.0±11.6 years, men 50%) from January
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Long‐Term Safety and Efficacy of Mavacamten in Symptomatic Obstructive Hypertrophic Cardiomyopathy: Interim Results of the PIONEER‐OLE Study J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-09 Ahmad Masri, Steven J. Lester, John C. Stendahl, Sheila M. Hegde, Amy J. Sehnert, Ganesh Balaratnam, Ashish Shah, Shawna Fox, Andrew Wang
BackgroundThe phase 2 PIONEER‐HCM (Phase 2 Open‐label Pilot Study Evaluating Mavacamten in Subjects With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction) study showed that mavacamten improved left ventricular outflow tract gradients, exercise capacity, and symptoms in patients with obstructive hypertrophic cardiomyopathy (HCM), but the results of longer‐term treatment
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Usefulness of Heart Failure Categories Based on Left Ventricular Ejection Fraction J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-09 Malin Christersson, Stefan Gustafsson, Erik Lampa, Matilda Almstedt, Thomas Cars, Johan Bodegård, Gabriel Arefalk, Johan Sundström
BackgroundHeart failure guidelines have recently introduced a narrow category with mildly reduced left ventricular ejection fraction (LVEF) (heart failure with mildly reduced ejection fraction; LVEF 41%–49%) between the previous categories of reduced (heart failure with reduced ejection fraction; LVEF ≤40%) and preserved (heart failure with preserved ejection fraction; LVEF ≥50%) ejection fraction
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Guilt and Reproductive Decision‐Making in Patients With Inherited Cardiac Diseases J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-09 Emily Smith, Dhurga Krishnamoorthy, Carolyn Burke‐Martindale, Adaya Weissler‐Snir
A diagnosis of an inherited cardiac condition may cause guilt for having the condition (personal guilt) and for passing it to one's offspring (reproductive guilt) and also may affect reproductive decision‐making. Previous studies have shown there is a higher prevalence of depression and anxiety among patients with genetic heart condition and reproductive decisions are complex and often dependent on
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Do Individuals With Inherited Cardiac Diseases Experience Reproductive Decision‐Making Guilt? J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-09 Cheryl A. Tucker, Kathryn Osteen
Inherited cardiac disease is an umbrella term that includes a broad range of genetic conditions affecting the heart including cardiomyopathies, arrhythmias, congenital heart disorders, and fetal cardiovascular disorders.1 These cardiac conditions increase an individual's risk for cardiovascular events, predisposing them to sudden cardiac death.2 The 2024 Heart Disease and Stroke Statistics: A Report
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Left Ventricular Ejection Fraction in Heart Failure: Crazy, Stupid Love—and Maybe, Redemption J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-09 Milton Packer
The measurement of left ventricular ejection fraction (LVEF) was first proposed by Stuart Bartle, a young cardiovascular researcher at University of Virginia in the early 1960s.1 Based on images derived from contrast cineangiography, he coined the term ejected fraction to describe the ratio of stroke volume to LV end‐diastolic volume (LVEDV). At the time, no one thought that the calculation of LVEF
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Discordance Between Very Low‐Density Lipoprotein Cholesterol and Low‐Density Lipoprotein Cholesterol Increases Cardiovascular Disease Risk in a Geographically Defined Cohort J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-09 Kristina E. Seehusen, Alan T. Remaley, Maureen Sampson, Jeffrey W. Meeusen, Nicholas B. Larson, Paul A. Decker, Jill M. Killian, Paul Y. Takahashi, Véronique L. Roger, Sheila M. Manemann, Reyna Lam, Suzette J. Bielinski
BackgroundClinical risk scores are used to identify those at high risk of atherosclerotic cardiovascular disease (ASCVD). Despite preventative efforts, residual risk remains for many individuals. Very low‐density lipoprotein cholesterol (VLDL‐C) and lipid discordance could be contributors to the residual risk of ASCVD.Methods and ResultsCardiovascular disease–free residents, aged ≥40 years, living
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Impact of a Chronic Total Coronary Occlusion on the Incidence of Appropriate Implantable Cardioverter‐Defibrillator Shocks and Mortality: A Substudy of the Dutch Outcome in ICD Therapy (DO‐IT)) Registry J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-09 Anna van Veelen, Tom E. Verstraelen, Yvemarie B. O. Somsen, Joëlle Elias, Ivo M. van Dongen, Peter Paul H. M. Delnoy, Marcoen F. Scholten, Lucas V. A. Boersma, Alexander H. Maass, Sipke Strikwerda, Mehran Firouzi, Cornelis P. Allaart, Kevin Vernooy, Robert W. Grauss, Raymond Tukkie, Paul Knaapen, Aeilko H. Zwinderman, Marcel G. W. Dijkgraaf, Bimmer E. P. M. Claessen, Marit van Barreveld, Arthur A.
BackgroundChronic total coronary occlusions (CTO) substantially increase the risk for sudden cardiac death. Among patients with chronic ischemic heart disease at risk for sudden cardiac death, an implantable cardioverter defibrillator (ICD) is the favored therapy for primary prevention of sudden cardiac death. This study sought to investigate the impact of CTOs on the risk for appropriate ICD shocks
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Validation of a Suprasystolic Cuff System for Static and Dynamic Representation of the Central Pressure Waveform J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-09 Alessio Tamborini, Morteza Gharib
BackgroundNoninvasive pulse waveform analysis is valuable for central cardiovascular assessment, yet controversies persist over its validity in peripheral measurements. Our objective was to compare waveform features from a cuff system with suprasystolic blood pressure hold with an invasive aortic measurement.Methods and ResultsThis study analyzed data from 88 subjects undergoing concurrent aortic catheterization
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Food Insecurity and Ideal Cardiovascular Health Risk Factors Among US Adolescents J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-09 Nour M. Hammad, Julia A. Wolfson, Sarah D. de Ferranti, Walter C. Willett, Cindy W. Leung
BackgroundFood insecurity, a social and economic condition of limited availability of healthy food, is a risk factor for adverse cardiovascular health outcomes among adults; few studies have been conducted in adolescents. This study explores the association between food insecurity and cardiovascular health risk factors among a nationally representative sample of US adolescents, adopting the American
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Influence of Body Mass Index on Radiation Exposure Across Imaging Modalities in the Evaluation of Chest Pain J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-09 Brett W. Sperry, Mary Stefanie Vamenta, Satya Preetham Gunta, Randall C. Thompson, Andrew J. Einstein, Michelle Castillo, Priyanka D. Chaudhary, Luca I. Bremner, Yosef A. Cohen, Timothy M. Bateman, A. Iain McGhie
BackgroundEssential to a patient‐centered approach to imaging individuals with chest pain is knowledge of differences in radiation effective dose across imaging modalities. Body mass index (BMI) is an important and underappreciated predictor of effective dose. This study evaluated the impact of BMI on estimated radiation exposure across imaging modalities.Methods and ResultsThis was a retrospective
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Genetic Testing for Supravalvar Aortic Stenosis: What to Do When It Is Not Williams Syndrome J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-09 Sara B. Stephens, Tyler Novy, Gabrielle N. Spurzem, Benjamin Jacob, Taylor Beecroft, Emily Soludczyk, Beth A. Kozel, Justin Weigand, Shaine A. Morris
BackgroundWe aimed to describe the frequency and yield of genetic testing in supravalvar aortic stenosis (SVAS) following negative evaluation for Williams‐Beuren syndrome (WS).Methods and ResultsThis retrospective cohort study included patients with SVAS at our institution who had a negative evaluation for WS from May 1991 to September 2021. SVAS was defined as (1) peak supravalvar velocity of ≥2 meters/second
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Trends and Disparities in Valvular Heart Disease Mortality in the United States From 1999 to 2020 J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-08 Min Choon Tan, Yong Hao Yeo, Boon Jian San, Addi Suleiman, Justin Z. Lee, Arka Chatterjee, Kristen A. Sell‐Dottin, John P. Sweeney, F. David Fortuin, Kwan S. Lee
BackgroundPercutaneous heart valve procedures have been increasingly performed over the past decade, yet real‐world mortality data on valvular heart disease (VHD) in the United States remain limited.Methods and ResultsWe queried the Centers for Disease Control and Prevention's Wide‐Ranging Online Data for Epidemiologic Research database among patients ≥15 years old from 1999 to 2020. VHD and its subtypes
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Effect of Active Workstations on Neurocognitive Performance and Typing Skills: A Randomized Clinical Trial J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-04 Jose R. Medina‐Inojosa, Miguel A. Gomez Ibarra, Betsy J. Medina‐Inojosa, Marta Supervia, Sarah Jenkins, Lynne Johnson, Nathalie P. Suarez, Amanda Bonikowske, Virend K. Somers, Francisco Lopez‐Jimenez
BackgroundExtended sedentary behavior is a risk factor for chronic disease and mortality, even among those who exercise regularly. Given the time constraints of incorporating physical activity into daily schedules, and the high likelihood of sitting during office work, this environment may serve as a potentially feasible setting for interventions to reduce sedentary behavior.Methods and ResultsA randomized
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Evaluating Readability, Understandability, and Actionability of Online Printable Patient Education Materials for Cholesterol Management: A Systematic Review J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-03 Chaitanya Bhatt, Ethan Lin, Laura E. Ferreira‐Legere, Cynthia A. Jackevicius, Dennis T. Ko, Douglas S. Lee, Kathryn Schade, Sharon Johnston, Todd J. Anderson, Jacob A. Udell
BackgroundDyslipidemia management is a cornerstone in cardiovascular disease prevention and relies heavily on patient adherence to lifestyle modifications and medications. Numerous cholesterol patient education materials are available online, but it remains unclear whether these resources are suitable for the majority of North American adults given the prevalence of low health literacy. This review
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Social Determinants of Cardiovascular Risk Factors Among Asian American Subgroups J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-03 Alicia L. Zhu, Austin D. Le, Yuemeng Li, Latha P. Palaniappan, Malathi Srinivasan, Nilay S. Shah, Sally S. Wong, Javier Valero‐Elizondo, Tali Elfassy, Eugene Yang
BackgroundSocial determinants of health (SDOH) play a significant role in the development of cardiovascular risk factors. We investigated SDOH associations with cardiovascular risk factors among Asian American subgroups.Methods and ResultsWe utilized the National Health Interview Survey, a nationally representative survey of US adults, years 2013 to 2018. SDOH variables were categorized into economic
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Prognostic Value of Right Ventricular Afterload in Patients Undergoing Mitral Transcatheter Edge‐to‐Edge Repair J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-03 Rody G. Bou Chaaya, Taha Hatab, Sahar Samimi, Fatima Qamar, Chloe Kharsa, Joe Aoun, Nadeen Faza, Stephen H. Little, Marvin D. Atkins, Michael J. Reardon, Neal S. Kleiman, Sherif F. Nagueh, William A. Zoghbi, Ashrith Guha, Syed Zaid, Sachin S. Goel
BackgroundPulmonary hypertension (PH) and secondary mitral regurgitation (MR) are associated with adverse outcomes after mitral transcatheter edge‐to‐edge repair. We aim to study the prognostic value of invasively measured right ventricular afterload in patients undergoing mitral transcatheter edge‐to‐edge repair.Methods and ResultsWe identified patients who underwent right heart catheterization ≤1
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Association of Cardiopulmonary Hemodynamics and Mortality in Veterans With Liver Cirrhosis: A Retrospective Cohort Study J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-03 Arun Jose, Natalia Rahman, Alexander R. Opotowsky, Thomas J. Glorioso, Stephen W. Waldo, Katarina Zeder, Arnold Seto, Jean M. Elwing, Francis X. McCormack, Bradley A. Maron
BackgroundPortopulmonary hypertension (PoPH), associated with increased mortality, can limit treatment options for liver diseases. Data on the continuum of clinical risk related to cardiopulmonary hemodynamics in PoPH are lacking.Methods and ResultsAs part of the United States national Veterans Affairs Clinical Assessment, Reporting, and Tracking database, we performed a retrospective cohort study
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Reference Values for Indexed Echocardiographic Chamber Sizes in Older Adults: The Multi‐Ethnic Study of Atherosclerosis J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-03 Jordan B. Strom, Monica Mukherjee, Lauren Beussink‐Nelson, Julius M. Gardin, Benjamin H. Freed, Sanjiv J. Shah, Jonathan Afilalo
BackgroundNormalization of echocardiographic chamber measurements for body surface area may result in misclassification of individuals with obesity or sarcopenia. Normalization for alternative measures of body size may be preferable, but there remains a dearth of information on their normative values and association with cardiovascular function metrics.Methods and ResultsA total of 3032 individuals
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Promoting Personal Health Literacy Through Readability, Understandability, and Actionability of Online Patient Education Materials J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-03 Cheryl A. Tucker
The culture of health care has its own shared norms, values, beliefs, customs, and language. Most patients enter the health care system with no formal training or understanding of the culture or language. To effectively communicate, providers must use common everyday vocabulary, speaking and writing in ways the patient understands.1 When my husband developed significant medical issues related to congenital
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It's All About That Right Ventricle J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-03 Ambreen F. Ali, Rhonda Miyasaka, Christine L. Jellis
Often the forgotten ventricle, the right ventricle is gaining traction as a major determinant of outcomes across a spectrum of cardiovascular disorders. In this context, there has been recent interest in the concept of right ventricle–pulmonary artery (PA) coupling, and particularly on the detrimental impact to outcomes when the RV can no longer compensate for elevated afterload and right ventricle–PA
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Extracranial Vascular Anomalies Driven by RAS/MAPK Variants: Spectrum and Genotype–Phenotype Correlations J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-02 Vanessa F. Schmidt, Friedrich G. Kapp, Constantin Goldann, Linda Huthmann, Beatrix Cucuruz, Richard Brill, Veronika Vielsmeier, Caroline T. Seebauer, Armin‐Johannes Michel, Max Seidensticker, Wibke Uller, Jakob B. W. Weiß, Alena Sint, Beate Häberle, Julia Haehl, Alexandra Wagner, Johanna Cordes, Annegret Holm, Denny Schanze, Jens Ricke, Melanie A. Kimm, Walter A. Wohlgemuth, Martin Zenker, Moritz Wildgruber
BackgroundWe aimed to correlate alterations in the rat sarcoma virus (RAS)/mitogen‐activated protein kinase pathway in vascular anomalies to the clinical phenotype for improved patient and treatment stratification.Methods and ResultsThis retrospective multicenter cohort study included 29 patients with extracranial vascular anomalies containing mosaic pathogenic variants (PVs) in genes of the RAS/mitogen‐activated
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Disulfiram Reduces Atherosclerosis and Enhances Efferocytosis, Autophagy, and Atheroprotective Gut Microbiota in Hyperlipidemic Mice J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-02 C. Alicia Traughber, Kara Timinski, Ashutosh Prince, Nilam Bhandari, Kalash Neupane, Mariam R. Khan, Esther Opoku, Emmanuel Opoku, Gregory Brubaker, Junchul Shin, Junyoung Hong, Babunageswararao Kanuri, Elif G. Ertugral, Prabhakara R. Nagareddy, Chandrasekhar R. Kothapalli, Olga Cherepanova, Jonathan D. Smith, Kailash Gulshan
BackgroundPyroptosis executor GsdmD (gasdermin D) promotes atherosclerosis in mice and humans. Disulfiram was recently shown to potently inhibit GsdmD, but the in vivo efficacy and mechanism of disulfiram's antiatherosclerotic activity is yet to be explored.Methods and ResultsWe used human/mouse macrophages, endothelial cells, and smooth muscle cells and a hyperlipidemic mouse model of atherosclerosis
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Cost‐Effectiveness of a Workplace‐Based Hypertension Management Program in Real‐World Practice in the Kailuan Study J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-02 Yan‐Feng Zhou, Shuohua Chen, Jun‐Xiang Chen, Simiao Chen, Guodong Wang, Xiong‐Fei Pan, Shouling Wu, An Pan
BackgroundIn 2009, a workplace‐based hypertension management program was launched among men with hypertension in the Kailuan study. This program involved monitoring blood pressure semimonthly, providing free antihypertensive medications, and offering personalized health consultations. However, the cost‐effectiveness of this program remains unclear.Methods and ResultsThis analysis included 12 240 participants
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Association Between Young Adult Characteristics and Blood Pressure Trajectories J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-02 Jaejin An, Heidi Fischer, Liang Ni, Mengying Xia, Soon Kyu Choi, Kerresa L. Morrissette, Rong Wei, Kristi Reynolds, Paul Muntner, Monika M. Safford, Andrew E. Moran, Brandon K. Bellows, Carmen R. Isasi, Norrina B. Allen, Vanessa Xanthakis, Lisandro D. Colantonio, Yiyi Zhang
BackgroundBlood pressure (BP) trajectories from young adulthood through middle age are associated with cardiovascular risk. We examined the associations of hypertension risk factors with BP trajectories among a large diverse sample.Methods and ResultsWe analyzed data from young adults, aged 18 to 39 years, with untreated BP <140/90 mm Hg at baseline from Kaiser Permanente Southern California (N=355 324)
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Correction to: Prevalence of Abnormal Heart Weight After Sudden Death in People Younger than 40 Years of Age J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-02
In the article by Zachary J Schoppen et al, “Prevalence of Abnormal Heart Weight After Sudden Death in People Younger than 40 Years of Age,” which published online September 4, 2020 (J Am Heart Assoc. 2020;9:e015699. DOI: 10.1161/JAHA.120.015699) and was included in the September 15, 2020 issue of the journal, corrections were needed. In the Statistical Analysis section, under Equation 1, the variables
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Correction to: Cost‐Effectiveness of Icosapent Ethyl in REDUCE‐IT USA: Results From Patients Randomized in the United States J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-02
Correction to: Cost‐Effectiveness of Icosapent Ethyl in REDUCE‐IT USA: Results From Patients Randomized in the United States In the article by William S. Weintraub et al, “Cost‐Effectiveness of Icosapent Ethyl in REDUCE‐IT USA: Results From Patients Randomized in the United States,” which published online December 29, 2023 (J Am Heart Assoc. 2024;13:e032413. DOI: 10.1161/JAHA.123.032413) and was included
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Historical Redlining and Heart Failure Outcomes Following Hospitalization in the Southeastern United States J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-02 Nicole D. Fields, Andrea Tristan Urrutia, Alanna A. Morris, Michael R. Kramer, Tené T. Lewis, Shivani A. Patel
BackgroundHistorical redlining, a discriminatory lending practice, is an understudied component of the patient risk environment following hospital discharge. We investigated associations between redlining, patient race, and outcomes following heart failure hospitalization.Methods and ResultsWe followed a hospital‐based cohort of Black and White patients using electronic medical records for acute heart
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γ‐Glutamyl Transferase and Long‐Term Survival in the SYNTAXES Trial: Is It Just the Liver? J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-02 Kai Ninomiya, Patrick W. Serruys, Scot Garg, Shigetaka Kageyama, Nozomi Kotoku, Shinichiro Masuda, Pruthvi C. Revaiah, Neil O'leary, Arie Pieter Kappetein, Michael J. Mack, David R. Holmes, Piroze M. Davierwala, Friedrich W. Mohr, Daniel J. F. M. Thuijs, Yoshinobu Onuma, for the SYNTAX Extended Survival (SYNTAXES) Investigators
BackgroundRecently, machine learning algorithms have identified preprocedural γ‐glutamyl transferase (GGT) as a significant predictor of long‐term mortality after coronary revascularization in the SYNTAX (Synergy Between PCI [Percutaneous Coronary Intervention] With Taxus and Cardiac Surgery) trial. The aim of the present study is to investigate the impact of preprocedural GGT on 10‐year all‐cause
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Long‐Term Clinical‐Pathologic Results of Enzyme Replacement Therapy in Prehypertrophic Fabry Disease Cardiomyopathy J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-02 Andrea Frustaci, Romina Verardo, Nicola Galea, Maria Alfarano, Michele Magnocavallo, Livia Marchitelli, Luigi Sansone, Manuel Belli, Mario Cristina, Emanuela Frustaci, Matteo Antonio Russo, Cristina Chimenti
BackgroundThe limited ability of enzyme replacement therapy (ERT) in removing globotriaosylceramide from cardiomyocytes is recognized for advanced Fabry disease cardiomyopathy (FDCM). Prehypertrophic FDCM is believed to be cured or stabilized by ERT. However, no pathologic confirmation is available. We report here on the long‐term clinical–pathologic impact of ERT on prehypertrophic FDCM.Methods and
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Quantitative Benefit–Risk Evaluation of Rivaroxaban in Patients After Peripheral Arterial Revascularization: The VOYAGER PAD Trial J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-02 Zhong Yuan, Bennett Levitan, Hsiaowei Deng, Michael Szarek, Rupert M. Bauersachs, Scott D. Berkowitz, Lloyd Haskell, Elliot S. Barnathan, Marc P. Bonaca
BackgroundThe VOYAGER PAD (Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Symptomatic Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities) trial compared rivaroxaban (2.5 mg twice a day) plus aspirin with aspirin alone in patients with symptomatic peripheral artery disease requiring endovascular
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Validation of TRI‐SCORE for Outcome Prediction After Isolated Tricuspid Valve Surgery in Asian Patients J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-02 Dae‐Young Kim, Jihoon Kim, Iksung Cho, Eun Kyoung Kim, Geu‐Ru Hong, Jong‐Won Ha, Sung‐Ji Park, Chi Young Shim
BackgroundTRI‐SCORE was recently developed in Europe as a risk model for predicting in‐hospital death after isolated tricuspid valve surgery. We aimed to validate TRI‐SCORE in an Asian population and investigate its value for predicting long‐term outcomes.Methods and ResultsThe TRI‐SCORE was calculated for 202 patients (65±11 years, 61% women, 81% functional tricuspid regurgitation) who underwent isolated
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Early Mortality, Cardiovascular, and Renal Diseases in Women's Lives Following Hypertensive Disorders of Pregnancy: The Prospective Nationwide Study CONCEPTION J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-02 Grégory Lailler, Clémence Grave, Amélie Gabet, Pierre Joly, Nolwenn Regnault, Catherine Deneux‐Tharaux, Vassilis Tstsaris, Geneviève Plu‐Bureau, Sandrine Kretz, Jacques Blacher, Valérie Olie
BackgroundWe aimed to evaluate the impact of hypertensive disorders of pregnancy occurrence, recurrence, onset time, and severity on mortality and on a wide range of cardiovascular outcomes in France.Methods and ResultsCONCEPTION (Cohort of Cardiovascular Diseases in Pregnancy) is a French nationwide prospective cohort using data from the National Health Data System. We included all women in CONCEPTION
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Cardiovascular Risk in Young Patients Diagnosed With Obstructive Sleep Apnea J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-02 Ida E. Albertsen, Jesper Bille, Gregory Piazza, Gregory Y. H. Lip, Peter B. Nielsen
BackgroundIn older adults, obstructive sleep apnea (OSA) has been associated with several cardiovascular complications. Whether young patients diagnosed with OSA also are at higher risk of developing subsequent cardiovascular disease is uncertain. We aimed to estimate the risk of developing an incident cardiovascular event among young patients diagnosed with OSA.Methods and ResultsWe linked nationwide
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Enantiomer‐Specific Cardiovascular Effects of the Ketone Body 3‐Hydroxybutyrate J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-02 Nigopan Gopalasingam, Niels Moeslund, Kristian Hylleberg Christensen, Kristoffer Berg‐Hansen, Jacob Seefeldt, Casper Homilius, Erik Nguyen Nielsen, Mie Ringgaard Dollerup, Aage K. Alstrup Olsen, Mogens Johannsen, Ebbe Boedtkjer, Niels Møller, Hans Eiskjær, Lars Christian Gormsen, Roni Nielsen, Henrik Wiggers
BackgroundThe ketone body 3‐hydroxybutyrate (3‐OHB) increases cardiac output (CO) by 35% to 40% in healthy people and people with heart failure. The mechanisms underlying the effects of 3‐OHB on myocardial contractility and loading conditions as well as the cardiovascular effects of its enantiomeric forms, D‐3‐OHB and L‐3‐OHB, remain undetermined.Methods and ResultsThree groups of 8 pigs each underwent
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Population Trends of New Prescriptions for Antihyperglycemics and Antihypertensives Between 2014 and 2022 J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-02 Amy Y. X. Yu, Peter C. Austin, Cynthia A. Jackevicius, Anna Chu, Jessalyn K. Holodinsky, Michael D. Hill, Noreen Kamal, Mukesh Kumar, Douglas S. Lee, Manav V. Vyas, Raed A. Joundi, Nadia A. Khan, Moira K. Kapral, Candace D. McNaughton
BackgroundIn the wake of pandemic‐related health decline and health care disruptions, there are concerns that previous gains for cardiovascular risk factors may have stalled or reversed. Population‐level excess burden of drug‐treated diabetes and hypertension during the pandemic compared with baseline is not well characterized. We evaluated the change in incident prescription claims for antihyperglycemics
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Current Trends in Hypertension Identification and Management: Insights from the National Health and Nutrition Examination Survey (NHANES) Following the 2017 ACC/AHA High Blood Pressure Guidelines J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-02 Joseph Heaton, Abbas Alshami, Steven Imburgio, Anton Mararenko, Matthew Schoenfeld, Brett Sealove, Arif Asif, Jesus Almendral
BackgroundHypertension is a global health issue associated with increased cardiovascular morbidity and mortality. This study aimed to investigate contemporary hypertension identification and management trends following the 2017 American College of Cardiology/American Heart Association guidelines.Methods and ResultsData from the National Health and Nutrition Examination Survey conducted from 2017 to
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Time to SGLT2 Inhibitors Initiation in Patients With Heart Failure J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-02 Jungyeon Moon, Jacob A. Udell, Alice Chong, Jiming Fang, Peter C. Austin, Dennis T. Ko, Therese A. Stukel, Clare L. Atzema, Gillian L. Booth, Karen Tu, David M. J. Naimark, Cynthia A. Jackevicius
Sodium‐glucose contransporter‐2 inhibitors (SGLT2i), originally developed for diabetes, are now recommended for patients with heart failure (HF). There is growing evidence that supports the use of SGLT2i in patients with HF, regardless of the presence of diabetes, to reduce the risk of cardiovascular death or hospitalization.1 Post hoc analyses of landmark trials have reinforced the benefit of the
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Two‐Week Interruption of Statin Therapy Results in an Exaggerated Inflammatory Monocyte Phenotype in Young Patients With Myocardial Infarction Without Standard Modifiable Risk Factors J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-02 Jan‐Quinten Mol, Julia van Tuijl, Siroon Bekkering, Laura Rodwell, Gheorghe A. M. Pop, Mihai G. Netea, Niels van Royen, Niels P. Riksen, Saloua El Messaoudi
In patients with myocardial infarction (MI) it is recommended to start high‐intensity statin therapy as early as possible, irrespective of cholesterol concentration at presentation. This recommendation is often not followed in patient groups who are viewed as low risk because of the absence of traditional risk factors. In young patients with established atherosclerosis, statin treatment is initiated
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Maintenance of Subcutaneous Implantable Cardioverter Defibrillators in Hypertrophic Cardiomyopathy Patients With Iatrogenic Left Bundle‐Branch Block After Septal Myectomy J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-04-02 Chockalingam A. Narayanan, Nadia Bokhari, Ethan J. Rowin, Martin S. Maron, Barry J. Maron, Mark S. Link, Christopher Madias
The subcutaneous implantable cardioverter defibrillator (SICD) is effective for sudden cardiac death prevention in patients with hypertrophic cardiomyopathy (HCM).1 SICDs can be used in eligible patients without pacing indications to avoid the potential complications associated with intravascular lead placement. Preimplant ECG screening to evaluate QRS and T‐wave sensing is performed to decrease the
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Correction to: Intravascular Imaging Findings After PCI in Patients With Focal and Diffuse Coronary Artery Disease J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-27
In the article by Hirofumi Ohashi et al, “Intravascular Imaging Findings After PCI in Patients With Focal and Diffuse Coronary Artery Disease,” which published online February 23, 2024 (J Am Heart Assoc. 2024;13:e032605. DOI: 10.1161/JAHA.123.032605) and was included in the March 5, 2024 issue of the journal, a correction was needed. The name of the 4th author, Frederic Bouisset, was incorrectly written
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Impact of a Medical Fitness Model on Incident Major Adverse Cardiovascular Events: A Prospective Cohort Study of 11 000 Members J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-27 Ranveer Brar, Reid H. Whitlock, Alan Katz, Michelle Di Nella, Paul Komenda, Clara Bohm, Claudio Rigatto, Navdeep Tangri, Carrie Solmundson, David Collister
BackgroundCardiovascular disease remains the leading cause of disease burden and death in the world. The medical fitness model may be an alternative public health strategy to address cardiovascular risk factors with medical integrated programming.Methods and ResultsWe performed a retrospective cohort study between January 1, 2005, and December 31, 2015. Adults (aged ≥18 years) who did not have a prior
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Trends and Disparities in Cardiovascular Death in Sarcoidosis: A Population‐Based Retrospective Study in the United States From 1999 to 2020 J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-27 Min Choon Tan, Yong Hao Yeo, Noreen Mirza, Boon Jian San, Jian Liang Tan, Justin Z. Lee, Joanne K. Mazzarelli, Andrea M. Russo
BackgroundDespite significant cardiac involvement in sarcoidosis, real‐world data on death due to cardiovascular disease among patients with sarcoidosis is not well established.Methods and ResultsWe queried the Centers for Disease Control and Prevention's Wide‐Ranging Online Data for Epidemiologic Research database for data on patients with sarcoidosis aged ≥25 years from 1999 to 2020. Diseases of
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Impact of an Impaired Maternal–Fetal Environment on Death in Children With Congenital Heart Defects Undergoing Surgery in Denmark From 1994 to 2018 J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-27 Rasmus Kristensen, Camilla Omann, Charlotte K. Ekelund, J. William Gaynor, Vibeke E. Hjortdal
BackgroundStudies show that an impaired maternal–fetal environment (iMFE) increases the mortality risk in children with single‐ventricle congenital heart defects (CHDs). We investigated the impact of an iMFE on death in children with various surgically corrected CHDs.Methods and ResultsIn this nationwide register‐based study, we examined the association between an iMFE (including preeclampsia, gestational
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Frailty and Metabolic Vulnerability in Heart Failure: A Community Cohort Study J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-27 Sant Kumar, Katherine M. Conners, Joseph J. Shearer, Jungnam Joo, Sarah Turecamo, Maureen Sampson, Anna Wolska, Alan T. Remaley, Margery A. Connelly, James D. Otvos, Nicholas B. Larson, Suzette J. Bielinski, Véronique L. Roger
BackgroundFrailty is common in heart failure (HF) and is associated with death but not routinely captured clinically. Frailty is linked with inflammation and malnutrition, which can be assessed by a novel plasma multimarker score: the metabolic vulnerability index (MVX). We sought to evaluate the associations between frailty and MVX and their prognostic impact.Methods and ResultsIn an HF community