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Examining the Impact of Layperson Rescuer Gender on the Receipt of Bystander CPR for Women in Cardiac Arrest Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-03-27 Shelby K. Shelton, John D. Rice, Christopher E. Knoepke, Daniel D. Matlock, Edward P. Havranek, Stacie L. Daugherty, Sarah M. Perman
BACKGROUND:Women who suffer a witnessed out-of-hospital cardiac arrest receive bystander cardiopulmonary resuscitation (CPR) less often than men. To understand this phenomenon, we queried whether there are differences in deterrents to providing CPR based on the rescuer’s gender.METHODS:Participants were surveyed using a national crowdsourcing platform. Participants ranked the following 5 previously
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Incorporation of Drone Technology Into the Chain of Survival for OHCA: Estimation of Time Needed for Bystander Treatment of OHCA and CPR Performance Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-03-26 Monique A. Starks, Audrey L. Blewer, Christine Chow, Edward Sharpe, Lee Van Vleet, Evan Arnold, Daniel M. Buckland, Anjni Joiner, Denise Simmons, Cynthia L. Green, Daniel B. Mark
BACKGROUND:Drone-delivered automated external defibrillators (AEDs) hold promises in the treatment of out-of-hospital cardiac arrest. Our objective was to estimate the time needed to perform resuscitation with a drone-delivered AED and to measure cardiopulmonary resuscitation (CPR) quality.METHODS:Mock out-of-hospital cardiac arrest simulations that included a 9-1-1 call, CPR, and drone-delivered AED
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Association of Traditional and Nontraditional Risk Factors in the Development of Strokes Among Young Adults by Sex and Age Group: A Retrospective Case-Control Study Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-03-26 Michelle H. Leppert, Sharon N. Poisson, Sharon Scarbro, Krithika Suresh, Lynda D. Lisabeth, Jukka Putaala, Lee H. Schwamm, Stacie L. Daugherty, Cathy J. Bradley, James F. Burke, P. Michael Ho
BACKGROUND:Despite women having fewer traditional risk factors (eg, hypertension, diabetes), strokes are more common in women than men aged ≤45 years. This study examined the contributions of traditional and nontraditional risk factors (eg, migraine, thrombophilia) in the development of strokes among young adults.METHODS:This retrospective case-control study used Colorado’s All Payer Claims Database
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Impact of Multidomain Frailty on the Mode of Death in Older Patients With Heart Failure: A Cohort Study Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-03-26 Koichi Ohashi, Yuya Matsue, Daichi Maeda, Yudai Fujimoto, Nobuyuki Kagiyama, Tsutomu Sunayama, Taishi Dotare, Kentaro Jujo, Kazuya Saito, Kentaro Kamiya, Hiroshi Saito, Yuki Ogasahara, Emi Maekawa, Masaaki Konishi, Takeshi Kitai, Kentaro Iwata, Hiroshi Wada, Masaru Hiki, Takatoshi Kasai, Hirofumi Nagamatsu, Tetsuya Ozawa, Katsuya Izawa, Shuhei Yamamoto, Naoki Aizawa, Kazuki Wakaume, Kazuhiro Oka, Shin-ichi
BACKGROUND:Although frailty is strongly associated with mortality in patients with heart failure (HF), the risk of which specific cause of death is associated with being complicated with frailty is unclear. We aimed to clarify the association between multidomain frailty and the causes of death in elderly patients hospitalized with HF.METHODS:We analyzed data from the FRAGILE-HF cohort, where patients
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Estimating Vitamin K Antagonist Anticoagulation Benefit in People With Atrial Fibrillation Accounting for Competing Risks: Evidence From 12 Randomized Trials Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-03-25 Sachin J. Shah, Carl van Walraven, Sun Young Jeon, John Boscardin, F.D. Richard Hobbs, Stuart J. Connolly, Michael D. Ezekowitz, Kenneth E. Covinsky, Margaret C. Fang, Daniel E. Singer
BACKGROUND:Patients with atrial fibrillation have a high mortality rate that is only partially attributable to vascular outcomes. The competing risk of death may affect the expected anticoagulant benefit. We determined if competing risks materially affect the guideline-endorsed estimate of anticoagulant benefit.METHODS:We conducted a secondary analysis of 12 randomized controlled trials that randomized
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Summertime for Cardiovascular AI Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-03-19 Rohan Khera, Jenna Wiens
Cardiovascular medicine has blazed the path as a data-driven and evidence-rich specialty. Throughout its rich history, cardiovascular care has leveraged progressively complex data for clinical management, beginning with acoustic data on a stethoscope, electrical information on 12-lead ECG and implanted devices, cardiac and vascular measurements with invasive pressure transducers, visualization of the
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Cost-Effectiveness of Intravascular Imaging-Guided Complex PCI: Prespecified Analysis of RENOVATE-COMPLEX-PCI Trial Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-03-13 David Hong, Jin Lee, Hankil Lee, Juhee Cho, Eliseo Guallar, Ki Hong Choi, Seung Hun Lee, Doosup Shin, Jong-Young Lee, Seung-Jae Lee, Sang Yeub Lee, Sang Min Kim, Kyeong Ho Yun, Jae Young Cho, Chan Joon Kim, Hyo-Suk Ahn, Chang-Wook Nam, Hyuck-Jun Yoon, Yong Hwan Park, Wang Soo Lee, Taek Kyu Park, Jeong Hoon Yang, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Young Bin Song, Joo-Yong Hahn, Danbee Kang, Joo Myung
BACKGROUND:Although clinical benefits of intravascular imaging-guided percutaneous coronary intervention (PCI) in patients with complex coronary artery lesions have been observed in previous trials, the cost-effectiveness of this strategy is uncertain.METHODS:RENOVATE-COMPLEX-PCI (Randomized Controlled Trial of Intravascular Imaging Guidance vs Angiography-Guidance on Clinical Outcomes After Complex
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Compression-Only or Standard Cardiopulmonary Resuscitation for Trained Laypersons in Out-of-Hospital Cardiac Arrest: A Nationwide Randomized Trial in Sweden Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-03-06 Gabriel Riva, Erik Boberg, Mattias Ringh, Martin Jonsson, Andreas Claesson, Anette Nord, Sten Rubertsson, Hans Blomberg, Per Nordberg, Sune Forsberg, Mårten Rosenqvist, Leif Svensson, Cecilia Andréll, Johan Herlitz, Jacob Hollenberg
BACKGROUND:The ongoing TANGO2 (Telephone Assisted CPR. AN evaluation of efficacy amonGst cOmpression only and standard CPR) trial is designed to evaluate whether compression-only cardiopulmonary resuscitation (CPR) by trained laypersons is noninferior to standard CPR in adult out-of-hospital cardiac arrest. This pilot study assesses feasibility, safety, and intermediate clinical outcomes as part of
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Relationship Between Social Support and Clinical Outcomes: An Evaluation of Participant-Nominated Treatment Supporters in the HOPE 4 Intervention Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-03-05 Anastasia Drakos, Tara McCready, Patricio Lopez-Jaramillo, Shofiqul Islam, Martin McKee, Salim Yusuf, JD Schwalm
BACKGROUND:The HOPE 4 trial (Heart Outcomes Prevention and Evaluation 4) investigated the effectiveness of a comprehensive, collaborative model of care, implemented in Colombia and Malaysia, which aimed to reduce cardiovascular disease risk in individuals with hypertension. One component of this intervention was the nomination of a treatment supporter, where participants could select a family member
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Patient Characteristics Associated With Using Transcatheter Left Atrial Appendage Occlusion Versus Oral Anticoagulants for Atrial Fibrillation Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-03-05 Kueiyu Joshua Lin, Daniel E. Singer, Jerry Avorn, E. Kevin Heist, Sushama Kattinakere Sreedhara, Priyanka Anand, Yichi Zhang, Theodore N. Tsacogianis, Sebastian Schneeweiss
BACKGROUND:Transcatheter left atrial appendage occlusion (LAAO) is an alternative to oral anticoagulants (OACs) for stroke prevention in patients with atrial fibrillation, but the predictors of LAAO use in routine care are unclear. We aimed to assess the utilization trends of LAAO and compare the change in characteristics of LAAO users versus OACs since its marketing.METHODS:Using the US Medicare claims
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Centering Medical Ethics Into Cardiovascular Medicine Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-02-20 Prateeti Khazanie, Daniel B. Kramer
Cardiovascular medicine is a data-driven field informed by large randomized clinical trials and clinical registries that shape daily practice and improve the quality of care worldwide. Cardiovascular specialists are used to applying evidence to guide our use of medications, tests, and procedures. We have many therapeutic options at our disposal, and there are lots of things we can do. By contrast,
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Ethical Complexity of Medical Treatment Affordability and Clinical Trial Diversity in Heart Failure Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-02-20 Birju R. Rao, Neal W. Dickert, Alanna A. Morris
Advancing health equity in patients with heart failure (HF) is an urgent priority. Structural inequalities and social determinants of health contribute to disparities in HF incidence, clinical outcomes, and access to therapies.1 However, isolating the best methods to study these inequalities and intervening upon identified targets is complex. Because patterns of inequity are interrelated and tightly
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Catalyzing Restructure of a Broken Health Care System Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-02-20 Khadijah Breathett, Kimberly D. Manning
I am and always will be a catalyst for change.1 —Shirley Chisholm In 1968—the same year when Martin Luther King, Jr., was assassinated—the tenacious Shirley Chisholm would become the first Black woman to obtain a seat in the US Congress.1 From her humble beginnings growing up in Brooklyn, NY, as the child of immigrants, she saw problems as possibilities and set out to change them. Shortly after her
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Why Does a Cardiologist Believe in a Therapy? The Role of Intuitiveness and Understanding the Mechanism Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-02-16 Michael J. Foley, Christopher A. Rajkumar, Fiyyaz Ahmed-Jushuf, Alexandra N. Nowbar, Florentina Simader, Olamide Bello, Rasha Al-Lamee
It is widely accepted that a medical intervention should demonstrate efficacy in the setting of a randomized controlled trial (RCT) before progressing to routine clinical use. For interventions designed to improve symptoms, we believe that the bar should be even higher, necessitating that the effect of a therapy be compared with placebo in a double-blind trial. In reality, many interventions that are
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How to Use Quasi-Experimental Methods in Cardiovascular Research: A Review of Current Practice Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-02-16 Alexander W. Carter, Sahan Jayawardana, Joan Costa-Font, Khurram Nasir, Harlan M. Krumholz, Elias Mossialos
BACKGROUND:Quasi-experimental methods (QEMs) are a family of techniques used to estimate causal relationships when randomized controlled trials are unfeasible or unethical. They offer a powerful alternative to observational studies by introducing random assignment of individuals or groups into their design, thereby offering stronger means of establishing causation. The use of QEMs in cardiovascular
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Trends in Patient Access to and Utilization of Prescribed PCSK9 Inhibitors in a Large US Claims Database From 2015 to 2021 Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-02-16 Diane E. MacDougall, Seth J. Baum, Catherine D. Ahmed, Mary P. McGowan, Katherine A. Wilemon
Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of death in the United States. LDL-C (low-density lipoprotein cholesterol) is a key driver and modifiable risk factor of ASCVD, particularly in high-risk patients, including those with genetic lipid disorders.1 PCSK9i (proprotein convertase subtilisin/kexin type 9) inhibitors represented a major advancement in LDL-C management
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Familial Hypercholesterolemia and Our Family’s Heart History: From Atherosclerosis and Angina to Awareness and Advocacy Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-02-15 Reed Mszar, Eugene Mszar
What does it mean to have a family history of a specific disease or illness? Is it simply an indicator of risk that merits close medical attention over time? Or does this information warrant something more? A referral to specialized care? A diagnosis of a potential genetic disorder? Additional health screenings for close relatives and younger generations? How should patients and their families navigate
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Neighborhood Disadvantage and Risk of Heart Failure: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-02-08 Gargya Malla, D. Leann Long, Andrea Cherrington, Parag Goyal, Boyi Guo, Monika M. Safford, Yulia Khodneva, Doyle M. Cummings, Tara P. McAlexander, Shanika DeSilva, Suzanne E. Judd, Bertha Hidalgo, Emily B. Levitan, April P. Carson
BACKGROUND:Heart failure (HF) affects >6 million US adults, with recent increases in HF hospitalizations. We aimed to investigate the association between neighborhood disadvantage and incident HF events and potential differences by diabetes status.METHODS:We included 23 645 participants from the REGARDS study (Reasons for Geographic and Racial Differences in Stroke), a prospective cohort of Black and
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Sex-Based Disparities in Acute Myocardial Infarction Treatment Patterns and Outcomes in Older Adults Hospitalized Across 6 High-Income Countries: An Analysis From the International Health Systems Research Collaborative Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-02-08 Hannah Lu, Laura A. Hatfield, Saeed Al-Azazi, Pieter Bakx, Amitava Banerjee, Nitzan Burrack, Yu-Chin Chen, Christina Fu, Michal Gordon, Renaud Heine, Nicole Huang, Dennis T. Ko, Lisa M. Lix, Victor Novack, Laura Pasea, Feng Qiu, Therese A. Stukel, Carin A. Uyl-de Groot, Gabe Weinreb, Bruce E. Landon, Peter Cram
BACKGROUND:Sex differences in acute myocardial infarction treatment and outcomes are well documented, but it is unclear whether differences are consistent across countries. The objective of this study was to investigate the epidemiology, use of interventional procedures, and outcomes for older females and males hospitalized with ST-segment–elevation myocardial infarction (STEMI) and non–ST-segment–elevation
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Safety and Effectiveness of the High-Sensitivity Cardiac Troponin HEART Pathway in Patients With Possible Acute Coronary Syndrome Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-02-08 Simon A. Mahler, Nicklaus P. Ashburn, Brennan E. Paradee, Jason P. Stopyra, James C. O’Neill, Anna C. Snavely
BACKGROUND:The HEART Pathway (History, Electrocardiogram, Age, Risk factors, Troponin) can be used with high-sensitivity cardiac troponin to risk stratify emergency department patients with possible acute coronary syndrome. However, data on whether a high-sensitivity HEART Pathway (hs-HP) are safe and effective is lacking.METHODS:An interrupted time series study was conducted at 5 North Carolina sites
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Impact of Residential Social Deprivation on Prediction of Heart Failure in Patients With Type 2 Diabetes: External Validation and Recalibration of the WATCH-DM Score Using Real World Data Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-02-08 Salil V. Deo, Sadeer Al-Kindi, Issam Motairek, David McAllister, Anoop S.V. Shah, Yakov E. Elgudin, Eiran Z. Gorodeski, Salim Virani, Mark C. Petrie, Sanjay Rajagopalan, Naveed Sattar
BACKGROUND:Patients with type 2 diabetes are at risk of heart failure hospitalization. As social determinants of health are rarely included in risk models, we validated and recalibrated the WATCH-DM score in a diverse patient-group using their social deprivation index (SDI).METHODS:We identified US Veterans with type 2 diabetes without heart failure that received outpatient care during 2010 at Veterans
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Cost of Cardiovascular Disease Event and Cardiovascular Disease Treatment–Related Complication Hospitalizations in the United States Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-02-08 Gabriel S. Tajeu, Natalia Ruiz-Negrón, Andrew E. Moran, Zugui Zhang, Paul Kolm, William S. Weintraub, Adam P. Bress, Brandon K. Bellows
BACKGROUND:Cardiovascular disease (CVD) is among the costliest conditions in the United States, and cost-effectiveness analyses can be used to assess economic impact and prioritize CVD treatments. We aimed to develop standardized, nationally representative CVD events and selected possible CVD treatment–related complication hospitalization costs for use in cost-effectiveness analyses.METHODS:Nationally
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Impact of Embedding a Venous Thromboembolism Risk Assessment Model in the Electronic Health Record Versus Usual Care: A Cluster-Randomized Trial Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-02-06 Michael B. Rothberg, Aaron C. Hamilton, Bo Hu, Megan Sheehan, Jacqueline Fox, Alex Milinovich, Oleg Lisheba, Toyomi Goto, Sidra L. Speaker, Matthew A. Pappas
Background:There are multiple risk assessment models (RAMs) for venous thromboembolism prophylaxis, but it is unknown whether they increase appropriate prophylaxis.Methods:To determine the impact of a RAM embedded in the electronic health record, we conducted a stepped-wedge hospital-level cluster-randomized trial conducted from October 1, 2017 to February 28, 2019 at 10 Cleveland Clinic hospitals
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Considering Social Context to Understand Childhood Adversities and Cardiovascular Health Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-01-23 Shakira F. Suglia, Ayana K. April-Sanders
Consistent evidence has identified childhood adversity as a significant determinant of physical and mental health. Childhood adversities, which include experiences such as child maltreatment, household dysfunction, bullying, exposure to crime, discrimination, bias, and victimization occurring before adulthood, place a substantial burden of adaptation on children and are recognized as social determinants
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Evidence for the Association Between Adverse Childhood Family Environment, Child Abuse, and Caregiver Warmth and Cardiovascular Health Across the Lifespan: The Coronary Artery Risk Development in Young Adults (CARDIA) Study Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-01-23 Robin Ortiz, Kiarri N. Kershaw, Songzhu Zhao, David Kline, Guy Brock, Sara Jaffee, Sherita H. Golden, Gbenga Ogedegbe, Judith Carroll, Teresa E. Seeman, Joshua J. Joseph
BACKGROUND:This study aimed to quantify the association between childhood family environment and longitudinal cardiovascular health (CVH) in adult CARDIA (Coronary Artery Risk Development in Young Adults) Study participants. We further investigated whether the association differs by adult income.METHODS:We applied the CVH framework from the American Heart Association including metrics for smoking,
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Classification Algorithm to Distinguish Between Type 1 and Type 2 Myocardial Infarction in Administrative Claims Data Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-01-19 Jason H. Wasfy, Mary Price, Sharon-Lise T. Normand, James L. Januzzi Jr, Cian P. McCarthy, John Hsu
BACKGROUND:Type 2 myocardial infarction (T2MI) and type 1 myocardial infarction (T1MI) differ with respect to demographics, comorbidities, treatments, and clinical outcomes. Reliable quality and outcomes assessment depends on the ability to distinguish between T1MI and T2MI in administrative claims data. As such, we aimed to develop a classification algorithm to distinguish between T1MI and T2MI that
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Identification of Fatigue Subtypes and Their Correlates in Prevalent Heart Failure: A Secondary Analysis of the Atherosclerosis Risk in Communities Study Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-01-19 Noelle Pavlovic, Chiadi E. Ndumele, Martha Abshire Saylor, Sarah L. Szanton, Christopher S. Lee, Amil M. Shah, Patricia P. Chang, Roberta Florido, Kunihiro Matsushita, Cheryl Himmelfarb, Jeannie Marie Leoutsakos
BACKGROUND:Among patients with heart failure (HF), fatigue is common and linked to quality of life and functional status. Fatigue is hypothesized to manifest as multiple types, with general and exertional components. Unique subtypes of fatigue in HF may require differential assessment and treatment to improve outcomes. We conducted this study to identify fatigue subtypes in persons with prevalent HF
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Role of Biomarkers of Myocardial Injury to Predict Adverse Outcomes in Hypertrophic Cardiomyopathy Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-01-19 Yu Zhang, Minghao Liu, Channa Zhang, Yubao Zou, Lianming Kang, Lei Song
BACKGROUND:Serum troponins and CK-MB (creatine kinase-MB) are readily detectable and reliable cardiac-specific biomarkers of subclinical myocardial injury. This study explores the roles of cTnI (cardiac troponin I) and CK-MB in hypertrophic cardiomyopathy (HCM).METHODS:This study included 1045 patients with HCM who had baseline cTnI and CK-MB measurements at Fuwai Hospital between 1999 and 2019. Patients
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Transformational Journey of Outcomes Research: Looking Back From the Future Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-01-16 Harlan M. Krumholz
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Approval, Evidence, and “Off-Label” Device Utilization: The Patent Foramen Ovale Closure Story Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-01-08 Andrew M. Goldsweig, Yihong Deng, Xiaoxi Yao, Nihar R. Desai, David J. Cohen, Herbert D. Aronow, Steven R. Messé, Joseph S. Ross, Alexandra J. Lansky, Samuel T. Savitz
BACKGROUND: Following regulatory approval, medical devices may be used “off-label.” Patent foramen ovale (PFO) closure is indicated to reduce recurrent stroke but has been proposed for other indications, including migraine, transient ischemic attack, and diving decompression illness. We sought to evaluate PFO closure rates and indications relative to the timing of regulatory approval and publication
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Referral to Community-Based Rehabilitation Following Acute Stroke: Findings From the COMPASS Pragmatic Trial Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-01-08 Sara B. Jones Berkeley, Anna M. Johnson, Elizabeth R. Mormer, Kristin Ressel, Amy M. Pastva, Fang Wen, Charity G. Patterson, Pamela W. Duncan, Cheryl D. Bushnell, Shuqi Zhang, Janet K. Freburger
BACKGROUND: Few studies on care transitions following acute stroke have evaluated whether referral to community-based rehabilitation occurred as part of discharge planning. Our objectives were to describe the extent to which patients discharged home were referred to community-based rehabilitation and identify the patient, hospital, and community-level predictors of referral. METHODS: We examined data
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Why Are We Weighting? Understanding the Estimates From Propensity Score Weighting and Matching Methods Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-01-08 Niveditta Ramkumar, Alexander Iribarne, Elaine M. Olmstead, David J. Malenka, Todd A. Mackenzie
BACKGROUND: Propensity score methods are used in observational studies to compensate for the lack of random allocation by balancing measured baseline characteristics between treated and untreated patients. We sought to explain the treatment effect estimates derived from different propensity score methods. METHODS: We performed a retrospective analysis of long-term mortality after single internal mammary
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Navigating the Gray: The Complex Story of PFO Closure Utilization Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-01-08 Karen D. Orjuela, Michelle H. Leppert, John D. Carroll
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Interhospital Variation in Admissions Managed With Critical Care Therapies or Invasive Hemodynamic Monitoring in Tertiary Cardiac Intensive Care Units: An Analysis From the Critical Care Cardiology Trials Network Registry Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2024-01-05 Sarah Donnelly, Christopher F. Barnett, Erin A. Bohula, Sunit-Preet Chaudhry, Meshe D. Chonde, Howard A. Cooper, Lori B. Daniels, Mark W. Dodson, Daniel Gerber, Michael J. Goldfarb, Jianping Guo, Michael C. Kontos, Shuangbo Liu, Adriana C. Luk, Venu Menon, Connor G. O’Brien, Alexander I. Papolos, Barbara A. Pisani, Brian J. Potter, Rajnish Prasad, Gregory Schnell, Kevin S. Shah, Lakshmi Sridharan,
BACKGROUND: Wide interhospital variations exist in cardiovascular intensive care unit (CICU) admission practices and the use of critical care restricted therapies (CCRx), but little is known about the differences in patient acuity, CCRx utilization, and the associated outcomes within tertiary centers. METHODS: The Critical Care Cardiology Trials Network is a multicenter registry of tertiary and academic
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Association Between Delays in Time to Bystander CPR and Survival for Witnessed Cardiac Arrest in the United States Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2023-12-26 Dan D. Nguyen, John A. Spertus, Kevin F. Kennedy, Kashvi Gupta, Anezi I. Uzendu, Bryan F. McNally, Paul S. Chan
Background: Prompt initiation of bystander cardiopulmonary resuscitation (CPR) is critical to survival for out-of-hospital cardiac arrest (OHCA). However, the association between delays in bystander CPR and OHCA survival is poorly understood. Methods: In this observational study using a nationally representative US registry, we identified patients who received bystander CPR from a layperson for a witnessed
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Days at Home After Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2023-12-12 Mabel Chung, Zaid I. Almarzooq, Jiaman Xu, Yang Song, Suzanne J. Baron, Dhruv S. Kazi, Robert W. Yeh
BACKGROUND: Days at home (DAH) represents an important patient-oriented outcome that quantifies time spent at home after a medical event; however, this outcome has not been fully evaluated for low-surgical-risk patients undergoing transcatheter aortic valve replacement (TAVR). We sought to compare 1- and 2-year DAH (DAH 365 and DAH 730 ) among low-risk patients participating in a randomized trial of
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Neighborhoods and Cardiovascular Health: A Scientific Statement From the American Heart Association Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2023-12-11 Kiarri N. Kershaw, Jared W. Magnani, Ana V. Diez Roux, Marlene Camacho-Rivera, Elizabeth A. Jackson, Amber E. Johnson, Gayenell S. Magwood, Lewis B. Morgenstern, Jennifer J. Salinas, Mario Sims, Mahasin S. Mujahid
The neighborhoods where individuals reside shape environmental exposures, access to resources, and opportunities. The inequitable distribution of resources and opportunities across neighborhoods perpetuates and exacerbates cardiovascular health inequities. Thus, interventions that address the neighborhood environment could reduce the inequitable burden of cardiovascular disease in disenfranchised populations
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Home Hospital Outcomes for Acute Decompensated Heart Failure and Factors Associated With Escalation of Care Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2023-12-06 Aditya Achanta, Jason H. Wasfy, Carson Tyler Moss, Abraham Cherukara, David Ho, Robert Boxer, Malte Schmieding, Neelam Ameya Phadke, Ryan Thompson, David Michael Levine, Rory B. Weiner
BACKGROUND: Overall outcomes and the escalation rate for home hospital admissions for heart failure (HF) are not known. We report overall outcomes, predict escalation, and describe care provided after escalation among patients admitted to home hospital for HF. METHODS: Our retrospective analysis included all patients admitted for HF to 2 home hospital programs in Massachusetts between February 2020
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Association of Neighborhood-Level Marginalization With Health Care Use and Clinical Outcomes Following Hospital Discharge in Patients Who Underwent Coronary Catheterization for Acute Myocardial Infarction in a Single-Payer Health Care System Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2023-12-05 Leo E. Akioyamen, Husam Abdel-Qadir, Lu Han, Maneesh Sud, Nikhil Mistry, David A. Alter, Clare L. Atzema, Peter C. Austin, R. Sacha Bhatia, Gillian L. Booth, Irfan Dhalla, Andrew C.T. Ha, Cynthia A. Jackevicius, Moira K. Kapral, Harlan M. Krumholz, Douglas S. Lee, Candace D. McNaughton, Idan Roifman, Michael J. Schull, Atul Sivaswamy, Karen Tu, Jacob A. Udell, Harindra C. Wijeysundera, Dennis T. Ko
BACKGROUND: Canadian data suggest that patients of lower socioeconomic status with acute myocardial infarction receive less beneficial therapy and have worse clinical outcomes, raising questions regarding care disparities even in universal health care systems. We assessed the contemporary association of marginalization with clinical outcomes and health services use. METHODS: Using clinical and administrative
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Intensive Versus Traditional Cardiac Rehabilitation: Mortality and Cardiovascular Outcomes in a 2016–2020 Retrospective Medicare Cohort Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2023-12-01 Mustafa Husaini, Elena Deych, R.J. Waken, Blake Sells, Andrew Lai, Susan B. Racette, Michael W. Rich, Karen E. Joynt Maddox, Linda R. Peterson
BACKGROUND: Traditional cardiac rehabilitation (CR) improves cardiovascular outcomes and reduces mortality, but less is known about the relative benefit of intensive CR (ICR) which incorporates greater lifestyle education through 72 sessions (versus 36 in CR). Our objective was to determine whether ICR is associated with a mortality and cardiovascular benefit compared with CR. METHODS: Retrospective
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Fourth Trimester: Assessing Women’s Health Equity and Long-Term Cardiovascular Outcomes in a Large Midwestern Health System in 2021 Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2023-11-27 Delaine Teabout Thomas, Gretchen Benson, Anna Gan, Sarah Schwager, Brynn Okeson, Courtney Jordan Baechler
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Better: Reflections on Retraction and Republication in Science Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2023-11-21 Brahmajee K. Nallamothu
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Eligibility for Cardiovascular Risk Reduction Therapy in the United States Based on SELECT Trial Criteria: Insights From the National Health and Nutrition Examination Survey Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2023-11-11 Yuan Lu, Yuntian Liu, Ania M. Jastreboff, Rohan Khera, Chima D. Ndumele, Fatima Rodriguez, Karol E. Watson, Harlan M. Krumholz
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Ten Steps Toward Improving In-Hospital Cardiac Arrest Quality of Care and Outcomes Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2023-11-10 Brahmajee K. Nallamothu, Robert Greif, Theresa Anderson, Huba Atiq, Thomaz Bittencourt Couto, Julie Considine, Allan R. De Caen, Therese Djärv, Ann Doll, Matthew J. Douma, Dana P. Edelson, Feng Xu, Judith C. Finn, Grace Firestone, Saket Girotra, Kasper G. Lauridsen, Carrie Kah-Lai Leong, Swee Han Lim, Peter T. Morley, Laurie J. Morrison, Ari Moskowitz, Ajit Mullasari Sankardas, Mahmoud Tageldin Mustafa
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Off-Label Dosing of Direct Oral Anticoagulants Among Inpatients With Atrial Fibrillation in the United States Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2023-11-06 Amneet Sandhu, Lisa A. Kaltenbach, Karen Chiswell, Vijay Shimoga, Carmel Ashur, Abby Pribish, Gregg C. Fonarow, Jonathan P. Piccini, P. Michael Ho, Paul D. Varosy, Paul L. Hess
BACKGROUND: Among patients hospitalized for atrial fibrillation, the frequency of off-label direct oral anticoagulant (DOAC) dosing, associated factors, hospital-level variation, and temporal trends in contemporary practice are unknown. METHODS: Using the Get With The Guidelines–Atrial Fibrillation registry, patients admitted from January 1, 2014, to March 31, 2020, and discharged on DOACs were stratified
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Percutaneous Coronary Intervention for Heart Failure: Worth the Cost? Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2023-11-06 Saket Girotra, Dharam J. Kumbhani
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Percutaneous Revascularization for Ischemic Left Ventricular Dysfunction: Cost-Effectiveness Analysis of the REVIVED-BCIS2 Trial Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2023-11-06 Carlos Chivardi, Holly Morgan, Mark J. Sculpher, Tim Clayton, Richard Evans, Matthew Dodd, Mark Petrie, Christopher A. Rinaldi, Peter O'Kane, Louise Brown, Divaka Perera, Pedro Saramago, Divaka Perera, Amedeo Chiribiri, Gerry Carr-White, Antonis Pavlidis, Simon Redwood, Brian Clapp, Aldo Rinaldi, Haseeb Rahman, Natalia Briceno, Sophie Arnold, Amy Raynsford, Karen Wilson, Lucy Clack, Mark Petrie, Margaret
BACKGROUND: Percutaneous coronary intervention (PCI) is frequently undertaken in patients with ischemic left ventricular systolic dysfunction. The REVIVED (Revascularization for Ischemic Ventricular Dysfunction)-BCIS2 (British Cardiovascular Society-2) trial concluded that PCI did not reduce the incidence of all-cause death or heart failure hospitalization; however, patients assigned to PCI reported
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Health Care Access and Cardiovascular Risk Factor Management Among Working-Age US Adults During the Pandemic Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2023-11-06 Lucas X. Marinacci, Victoria Bartlett, ZhaoNian Zheng, Stephen Mein, Rishi K. Wadhera
BACKGROUND: Low-income working-age US adults disproportionately experienced health care disruptions at the onset of the coronavirus disease 2019 pandemic. Little is known about how health care access and cardiovascular risk factor management changed as the pandemic went on or if patterns differed by state Medicaid expansion status. METHODS: Cross-sectional data from the behavioral risk factor surveillance
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Evolution of Value in American College of Cardiology/American Heart Association Clinical Practice Guidelines Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2023-11-03 Andrea Luviano, Ankur Pandya
BACKGROUND: In January 2014, the American College of Cardiology/American Heart Association released a policy statement arguing for the inclusion of cost-effectiveness analysis (CEA) and value assessments in clinical practice guidelines. It is unclear whether subsequent guidelines changed how they incorporated such concepts. METHODS: We analyzed guidelines of cardiovascular disease subconditions with
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Telehealth and Health Equity in Older Adults With Heart Failure: A Scientific Statement From the American Heart Association Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2023-11-01 Ruth Masterson Creber, John A. Dodson, Julie Bidwell, Khadijah Breathett, Courtney Lyles, Carolyn Harmon Still, Sze-Yuan Ooi, Clyde Yancy, Spyros Kitsiou
Enhancing access to care using telehealth is a priority for improving outcomes among older adults with heart failure, increasing quality of care, and decreasing costs. Telehealth has the potential to increase access to care for patients who live in underresourced geographic regions, have physical disabilities or poor access to transportation, and may not otherwise have access to cardiologists with
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Opportunistic Screening for Subclinical Atrial Fibrillation: It Is Cost-Effective, but Is It Effective? Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2023-10-31 Emily P. Zeitler, Derek S. Chew, Daniel B. Mark
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Cost-Effectiveness of AF Screening With 2-Week Patch Monitors: The mSToPS Study Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2023-10-31 Matthew R. Reynolds, Amy B. Stein, Xiaowu Sun, Evangelos Hytopoulos, Steven R. Steinhubl, David J. Cohen
BACKGROUND: The mSToPS study (mHealth Screening to Prevent Strokes) reported screening older Americans at risk for atrial fibrillation (AF) and stroke using 2-week patch monitors was associated with increased rates of AF diagnosis and anticoagulant prescription within 1 year and improved clinical outcomes at 3 years relative to matched controls. Cost-effectiveness of this AF screening approach has
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Comparison of Atherosclerotic Cardiovascular Risk Factors and Cardiometabolic Profiles Between Current and Never Users of Marijuana Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2023-10-20 Hassan A. Alhassan, Harriet Akunor, Ato Howard, Joseph Donohue, Aleesha Kainat, Henry K. Onyeaka, Aryan Aiyer
BACKGROUND: The relationship between marijuana use and cardiovascular health remains uncertain, with several observational studies suggesting a potential association with increased adverse atherosclerotic cardiovascular disease (ASCVD) outcomes. This study examined the relationship between marijuana use, ASCVD risk factors, and cardiometabolic risk profiles. METHODS: US adults (18–59 years) without
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Relationship Between Community-Level Distress and Cardiac Rehabilitation Participation, Facility Access, and Clinical Outcomes After Inpatient Coronary Revascularization Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2023-10-19 Michael P. Thompson, Hechuan Hou, James W. Stewart, Francis D. Pagani, Robert B. Hawkins, Steven J. Keteyian, Devraj Sukul, Donald S. Likosky
BACKGROUND: Although disparities in cardiac rehabilitation (CR) participation are well documented, the role of community-level distress is poorly understood. This study evaluated the relationship between community-level distress and CR participation, access to CR facilities, and clinical outcomes. METHODS: A retrospective cohort study was conducted on a 100% sample of Medicare beneficiaries undergoing
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Use of Satellite-Sites for Percutaneous Cardiac Ablations (the Hub-and-Spoke Model): Lessons From the COVID-19 Pandemic Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2023-10-19 Ven Gee Lim, Hejie He, Thomas Lachlan, Ahmed Ammar, William Foster, Sandeep Panikker, Tarv Dhanjal, Shamil Yusuf, Kiran Patel, Faizel Osman
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Facilitating Harmonization of Variables in Framingham, MESA, ARIC, and REGARDS Studies Through a Metadata Repository Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2023-10-18 Pratheek Mallya, Laura M. Stevens, Juan Zhao, Chuan Hong, Ricardo Henao, Nicoleta Economou-Zavlanos, Daniel M. Wojdyla, Tony Schibler, Vihaan Manchanda, Michael J. Pencina, Jennifer L. Hall
BACKGROUND: High-quality research in cardiovascular prevention, as in other fields, requires inclusion of a broad range of data sets from different sources. Integrating and harmonizing different data sources are essential to increase generalizability, sample size, and representation of understudied populations—strengthening the evidence for the scientific questions being addressed. METHODS: Here, we
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Prescription Journey for Many Circ. Cardiovasc. Qual. Outcomes (IF 6.9) Pub Date : 2023-10-17 Lisa Johnson