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Causal Relationship Between Immune Cells/Cytokines and Dilated Cardiomyopathy A Mendelian Randomization Study Int. Heart J. (IF 1.5) Pub Date : 2024-03-30 Bin Qi, Nan Huang, Zhi-Jie Yang, Wen-Bo Zheng, Chun Gui
To date, whether there is any causal relationship between dilated cardiomyopathy (DCM) and the changes in the levels/expression of immune cells/cytokines is still unclear. This study aimed to investigate the causal relationship between the levels of various types of immune cells/cytokines and DCM. Herein, two-sample Mendelian randomization (MR) (TSMR) using R software was conducted. Single nucleotide
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Circ_0020887 Silencing Combats Hypoxic-Induced Cardiomyocyte Injury in an MiR-370-3p/CYP1B1-Dependent Manner Int. Heart J. (IF 1.5) Pub Date : 2024-03-30 Huiqin Chen, Zhendong Cheng, Meiai Wang, Qian Huang, Dandan Zheng, Qiuhong Huang, Kefeng Cai
Targeting circular RNA has been a novel approach to preventing and limiting acute myocardial infarction (AMI). Here, we planned to investigate the role and mechanism of circ_0020887 in AMI progression. Hypoxic injury in human cardiomyocytes (AC16) was measured using cell counting kit-8 assay, 5-ethynyl-2′-deoxyuridine assay, flow cytometry, and colorimetric assay kits. RNA and protein expressions were
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Efficacy and Tolerability of Ivabradine for Cardiomyopathy in Patients with Duchenne Muscular Dystrophy One Year Treatment Results in Japanese National Hospitals Int. Heart J. (IF 1.5) Pub Date : 2024-03-30 Akiko Wakisaka, Koichi Kimura, Hiroyuki Morita, Koki Nakanishi, Masao Daimon, Masanori Nojima, Hideki Itoh, Atsuhito Takeda, Ruriko Kitao, Tomihiro Imai, Tetsuhiko Ikeda, Takashi Nakajima, Chigusa Watanabe, Toshihiro Furukawa, Ichiro Ohno, Chiho Ishida, Norihiko Takeda, Kiyonobu Komai
Duchenne muscular dystrophy (DMD) is an intractable X-linked myopathy caused by dystrophin gene mutations. Patients with DMD suffer from progressive muscle weakness, inevitable cardiomyopathy, increased heart rate (HR), and decreased blood pressure (BP). The aim of this study was to clarify the efficacy and tolerability of ivabradine treatment for DMD cardiomyopathy. A retrospective analysis was performed
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Hydroxycitric Acid Tripotassium Hydrate Attenuates Monocrotaline and Hypoxia-Induced Pulmonary Hypertension in Rats Int. Heart J. (IF 1.5) Pub Date : 2024-03-30 Shunjun Wang, Huayang Li, Quan Liu, Husai Ma, Lin Huang, Laishun Yu, Zhongkai Wu
This study investigated the effects of hydroxycitric acid tripotassium hydrate on right ventricular function, myocardial and pulmonary vascular remodeling in rats with pulmonary hypertension, and possible mechanisms. Methods: Pulmonary hypertension was induced in male Sprague-Dawley rats by a single subcutaneous injection of monocrotaline or hypoxic chamber. In vivo, inflammatory cytokine (including
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Ponatinib-Related Vasospastic Angina Int. Heart J. (IF 1.5) Pub Date : 2024-03-30 Michiho Shindo, Chinatsu Komiyama, Tetsuo Yamaguchi, Kosei Kageyama, Hisashi Yamamoto, Yo Fujimoto, Naoyuki Uchida, Takahide Kodama
Tyrosine kinase inhibitors (TKIs) are essential drugs for chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. Cardiovascular or arteriothrombotic adverse events have been reported in patients treated with TKIs. We report 3 cases of Ponatinib-related vasospastic angina, in which prophylactic administration of nitrates or calcium channel blockers was effective
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Clinical Significance of the Triglyceride-Glucose Index in Patients Requiring Nonsurgical Intensive Care Int. Heart J. (IF 1.5) Pub Date : 2024-03-30 Suguru Nishigoori, Akihiro Shirakabe, Hirotake Okazaki, Masato Matsushita, Yusaku Shibata, Shota Shigihara, Tomofumi Sawatani, Kenichi Tani, Kazutaka Kiuchi, Nobuaki Kobayashi, Kuniya Asai
The evaluation of triglyceride-glucose (TyG) index has not been sufficient in patients requiring nonsurgical intensive care. A total of 3,906 patients who required intensive care were enrolled. We computed the TyG index using the value on admission by the following formula: ln [triglyceride (mg/dL) × glucose (mg/dL) /2]. Patients were divided into three groups according to the TyG index quartiles:
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Nutrition Assessment and Education of Patients with Heart Failure by Cardiologists A Cross-Sectional Study Int. Heart J. (IF 1.5) Pub Date : 2024-03-30 Taishi Dotare, Daichi Maeda, Yuya Matsue, Yutaka Nakamura, Tsutomu Sunayama, Takashi Iso, Taisuke Nakade, Tohru Minamino
Although nutritional assessment and education are important for hospitalized patients with heart failure, the extent of their implementation in real-world clinical practice is unknown. Therefore, this study aimed to investigate the evaluation and management of nutrition during hospitalization for heart failure using a questionnaire survey for cardiologists. In this cross-sectional multicenter survey
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B-Type Natriuretic Peptide Inhibits the Expression and Function of SERCA2a in Heart Failure Int. Heart J. (IF 1.5) Pub Date : 2024-03-30 Yuting Zhai, Junhong Chen, Rongsheng Kan, Haochen Xuan, Chaofan Wang, Dongye Li, Tongda Xu
B-type natriuretic peptide (BNP) possesses protective cardiovascular properties; however, there has not been sufficient serious consideration of the side effects of BNP. As for sarcoplasmic/endoplasmic reticulum calcium ATPase 2a (SERCA2a), it was once considered a new target for the treatment of heart failure (HF). Nevertheless, clinical trials of SERCA2a gene therapy in HF have finally become unsuccessful
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MiR-522-3p Attenuates Cardiac Recovery by Targeting FOXP1 to Suppress Angiogenesis Int. Heart J. (IF 1.5) Pub Date : 2024-03-30 Chunyu Li, Yanan Pu, Di Wang, Rong Cheng, Rui Xu, Qingyun Gong, Yi Jiang, Cheng Zhang, Yan Chen
Angiogenesis is crucial for blood supply reconstitution after myocardial infarction in patients with acute coronary syndrome (ACS). MicroRNAs are recognized as important epigenetic regulators of endothelial angiogenesis. The purpose of this study is to determine the roles of miR-522-3p in angiogenesis after myocardial infarction. The expression levels of miR-522-3p in rats' plasma and in the upper
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A Case of Ventricular Fibrillation in Masked Long-QT Syndrome Coexisting with Coronary Vasospasm Int. Heart J. (IF 1.5) Pub Date : 2024-03-30 Atsumasa Kurozumi, Yoshinari Enomoto, Hisao Hara, Norihiro Kato, Yukio Hiroi
Although long-QT syndrome (LQTS) with a normal range QT interval at rest leads to fatal ventricular arrhythmias, it is difficult to diagnose. In this article, we present a rare case of a patient who suffered a cardiac arrest and was recently diagnosed with LQTS and coronary vasospasm. A 62-year-old man with no syncopal episodes had a cardiopulmonary arrest while running. During coronary angiography
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Recent Advances on Selenium Nutrition and Keshan Disease Int. Heart J. (IF 1.5) Pub Date : 2024-03-30 Shu-Juan Li, An-Wei Wang, Kai-Lian Huang, Ying Yang
Keshan disease (KD) is a type of endemic cardiomyopathy with an unknown cause. It is primarily found in areas in China with low selenium levels, from northeast to southwest. The nutritional biogeochemical etiology hypothesis suggests that selenium deficiency is a major factor in KD development. Selenium is important in removing free radicals and protecting cells and tissues from peroxide-induced damage
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Impact of Red Blood Cell Transfusion on Subsequent Cardiovascular Events in Patients with Acute Heart Failure and Anemia Int. Heart J. (IF 1.5) Pub Date : 2024-03-30 Yukihiro Watanabe, Shuhei Tara, Takuya Nishino, Katsuhito Kato, Yoshiaki Kubota, Daisuke Hayashi, Kosuke Mozawa, Junya Matsuda, Hideki Miyachi, Yukichi Tokita, Yu-ki Iwasaki, Masahiro Yasutake, Kuniya Asai
Red blood cell (RBC) transfusion therapy is often performed in patients with acute heart failure (AHF) and anemia; however, its impact on subsequent cardiovascular events is unclear. We examined whether RBC transfusion influences major adverse cardiovascular events (MACE) after discharge in patients with AHF and anemia. We classified patients with AHF and anemia (nadir hemoglobin level < 10 g/dL) according
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Impact of Hemoglobin Level, White Blood Cell Count, Renal Dysfunction, and Staphylococcus as the Causative Organism on Prediction of In-Hospital Mortality from Infective Endocarditis A Single-Center Retrospective Cohort Study Int. Heart J. (IF 1.5) Pub Date : 2024-03-30 Masamichi Koike, Takahiro Doi, Koki Morishita, Kosuke Uruno, Mirei Kawasaki-Nabuchi, Kaoru Komuro, Hiroyuki Iwano, Syuichi Naraoka, Daigo Nagahara, Satoshi Yuda
Infective endocarditis (IE) is a highly fatal disease in cases of delayed diagnosis and treatment, although its incidence is low. However, there have been few single-center studies in which the risk of in-hospital death from IE was stratified according to laboratory findings on admission and the organism responsible for IE. In this study, a total of 162 patients who were admitted to our hospital during
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Clinical Value of Troponin Levels to Cardiac Function and Prognosis in Patients with Fulminant Myocarditis Int. Heart J. (IF 1.5) Pub Date : 2024-03-30 Naoki Shibata, Toru Kondo, Takahiro Okumura, Takahiro Imaizumi, Kaoru Dohi, Hideo Izawa, Nobuyuki Ohte, Tetsuya Amano, Toyoaki Murohara, on behalf of CHANGE PUMP 2 investigators
Troponin (Tn) is a biomarker related to myocardial necrosis and is elevated in patients with myocarditis. This study aimed to investigate the association between cardiac Tn levels and the course of cardiac function, and prognosis in patients with fulminant myocarditis (FM) receiving percutaneous mechanical circulatory support (MCS). We used data from a multicenter retrospective registry, CHANGE PUMP
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Comparison of the Pre-Established and Finally Selected Treatment Strategies for Endovascular Treatment in Femoropopliteal Artery Lesions Int. Heart J. (IF 1.5) Pub Date : 2024-03-30 Michiaki Higashitani, Daisuke Ueshima, Kenji Suzuki, Yasutaka Yamauchi, Mitsugu Hirokami, Yoshinori Tsubakimoto, Akihiko Takahashi, Taku Kato, Hiroshi Ando, Masato Nakamura
This study aimed to compare lower limb events associated with preplanned and finally selected treatment strategies-the validity and usefulness of the physician-chosen strategy were verified. We examined the data of 1003 patients in the registry of multicenter endovascular treatment for superficial femoral and popliteal artery disease study and prospectively enrolled patients who underwent endovascular
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U-Shaped Association between Serum Chloride Levels and In-Hospital Mortality in Patients with Congestive Heart Failure in Intensive Care Units A Retrospective Observational Study Int. Heart J. (IF 1.5) Pub Date : 2024-03-30 Kai Zhang, Yu Han, Fangming Gu, Zhaoxuan Gu, JiaYu Zhao, Jianguo Chen, Bowen Chen, Min Gao, Zhengyan Hou, Xiaoqi Yu, Tianyi Cai, Yafang Gao, Rui Hu, Jinyu Xie, Tianzhou Liu, Bo Li
Serum chloride level has clinical significance in the prognosis of heart failure. Little is known regarding the association between serum chloride levels and in-hospital mortality in patients with heart failure. This retrospective study used clinical data obtained from the Medical Information Mart for Intensive Care Database. The study cohort comprised patients who were categorized on the basis of
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H-type Hypertension Status and Influencing Factors of the Elderly People Over 80 Years Old Based on Random Forest Model Int. Heart J. (IF 1.5) Pub Date : 2024-03-30 Xiaobo Zhang, Botang Guo, Hong Zhu, Dahe Li, Yuanyuan Zhao, Qi Liu, Jingbo Hou
Hypertension is a common chronic disease in elderly people over 80 years old. Clinically, H-type hypertension occurs when hypertension coexists with hyperhomocysteinemia level of ≥ 10 umol/L. Effective identification of risk factors for H-type hypertension in the elderly can greatly improve patient prognosis. Consecutively, 494 patients with hypertension admitted to the Fourth Affiliated Hospital of
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Clinical Features and Outcomes of Shoshin Beriberi : A Retrospective Nationwide Database Study Int. Heart J. (IF 1.5) Pub Date : 2024-03-30 Yoshiki Mizuguchi, Hideyuki Mouri, Taisuke Jo, Yohei Hashimoto, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga, Takumi Taniguchi
Shoshin beriberi is a fulminant form of wet beriberi, but there are no large-scale studies detailing the clinical features of this disease. We investigated the clinical features and outcomes of Shoshin beriberi using data from a nationwide database in Japan. Using the Diagnosis Procedure Combination database, we identified patients with Shoshin beriberi between July 2010 and March 2021. We retrospectively
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lncRNA CCAT2 Protects Against Cardiomyocyte Injury After Myocardial Ischemia/Reperfusion by Regulating BMI1 Expression Int. Heart J. (IF 1.5) Pub Date : 2024-03-30 Mengli Zhang, Bei Xu, Wei Li, Bo Yu, Huan Peng, Feng Gui, Fen Ai, Zhen Chen
Myocardial ischemia/reperfusion (I/R) decreases cardiac function and efficiency. Accumulating evidence suggests that long noncoding RNAs (lncRNAs) have been linked to the cellular processes of myocardial I/R injury. The present investigation elucidated the function of lncRNA colon cancer-associated transcript 2 (CCAT2) in myocardial I/R injury and the related mechanisms. AC16 cardiomyocytes were exposed
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Platelet Microparticle-Derived MiR-320b Inhibits Hypertension with Atherosclerosis Development by Targeting ETFA Int. Heart J. (IF 1.5) Pub Date : 2024-03-30 Yongcong He, Yangyang Jiang, Fan Wu, Xiaoxue Zhang, Shaolan Liang, Zebing Ye
Hypertension and atherosclerosis often occur simultaneously. This study aimed to explore the role and mechanism of platelet microparticle (PMP) -derived microRNA-320b (miR-320b) in patients with hypertension accompanied by atherosclerosis. We collected samples from 13 controls without hypertension and atherosclerosis and 20 patients who had hypertension accompanied by atherosclerosis. In vitro, platelets
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Role of CCRL2 in the Pathogenesis of Experimental Autoimmune Myocarditis via P21-Activated Kinase 1/NOD-Like Receptor Protein 3 Pathway Int. Heart J. (IF 1.5) Pub Date : 2024-03-30 Lin Chen, Jing Meng, Jia Zheng, Tingting Zhao, Qi Li, Chengzhi Lu
Myocarditis, a severe inflammatory disease, is becoming a worldwide public health concern. This study aims to elucidate the effect of Chemokine (C C motif) receptor-like 2 (CCRL2) in experimental autoimmune myocarditis (EAM) occurrence and its potential regulatory mechanisms. EAM was simulated in a mouse model injected with α-myosin-heavy chain. The changes on EAM were assessed through histological
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Spontaneous Remission Without Steroid Therapy in Isolated Cardiac Sarcoidosis with Severe Left Ventricular Systolic Dysfunction Int. Heart J. (IF 1.5) Pub Date : 2024-03-30 Takaya Ozawa, Kenji Goto, Katsuya Miura, Kazunari Kobayashi, Yuetsu Kikuta, Katsumasa Sato, Masahito Taniguchi, Shigeki Hiramatsu, Hideo Takebayashi, Seiichi Haruta
Spontaneous remission is often observed in extracardiac cases of sarcoidosis, such as skin sarcoidosis. However, for cardiac sarcoidosis (CS), the prognosis is unfavorable. Although corticosteroids are the first-line treatment for CS, data regarding the natural history of isolated CS are limited. We describe a rare case of isolated CS with severe left ventricular systolic dysfunction that improved
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Congenital Pulmonary Lymphangiectasia Masked by Postoperative Pulmonary Venous Obstruction in an Infant with Total Anomalous Pulmonary Venous Connection Int. Heart J. (IF 1.5) Pub Date : 2024-03-30 Yoshiko Nawata, Daisuke Toyomura, Seigo Okada, Yasuo Suzuki, Narumi Honda-Nakada, Yuji Ohnishi, Yuichiro Sugitani, Naoki Kawaguchi, Rui Tokitaka-Okada, Naoki Masaki, Eiji Ikeda, Shunji Hasegawa
Congenital pulmonary lymphangiectasia (CPL) is associated with fetal pulmonary venous obstructive physiology. The precise morbidity of CPL is unknown as CPL is generally fatal in neonates. Here, we report an infant with secondary CPL in total anomalous pulmonary venous connection (TAPVC). He developed severe pulmonary hypertension (PH) after corrective surgery for TAPVC. However, cardiac catheterization
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Coexistence Case of Papillary Fibroelastoma and Lambl's Excrescence of the Left Heart, Which Is Occasionally Associated with Significant Stroke Int. Heart J. (IF 1.5) Pub Date : 2024-03-30 Takatoshi Unno, Ryuichi Kato, Masao Kuwada, Mitsunori Ishino, Takahiko Nagase, Takahisa Tanaka, Chiyo Yoshino, Takafumi Nishida, Yoshinori Yoshida, Ryo Oyama, Takafumi Kikuchi, Takayuki Tatebayashi, Sadahito Kuwao
Papillary fibroelastoma (PFE) is a benign tumor that arises mostly from left-sided valves. PFE can cause stroke, and surgical resection may be needed. Lambl's excrescence (LE) is a filiform valvular lesion and is considered a possible cause of stroke. A 79-year-old man with light-headedness and left-sided hemiparesis was diagnosed with stroke. Transesophageal echocardiography (TEE) revealed a round-shaped
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Errata: Effect of Thimerosal on Arrhythmia Induced by Coronary Ligation: The Involvement of ATP-dependent Potassium Channels Int. Heart J. (IF 1.5) Pub Date : 2024-03-30
Several errors (shown with underlines) in the following list appeared in the article "Effect of Thimerosal on Arrhythmia Induced by Coronary Ligation: The Involvement of ATP-dependent Potassium Channels" by Ömer Bozdogan, Ersöz Gonca, Melih Nebigil, Eylem Suveren Tiryaki (Vol. 46 No.4, 711-721, 2005).
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Predictive Value of Aortic Valve Calcium Volume Measured by Computed Tomography for Paravalvular Leakage After Transcatheter Aortic Valve Implantation Int. Heart J. (IF 1.5) Pub Date : 2024-01-31 Daisuke Isomatsu, Akihiko Sato, Yuuki Muto, Yu Sato, Takeshi Shimizu, Tomofumi Misaka, Takashi Kaneshiro, Masayoshi Oikawa, Atsushi Kobayashi, Akiomi Yoshihisa, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Takafumi Ishida, Hirofumi Sekino, Kenji Fukushima, Hiroshi Ito, Yasuchika Takeishi
Paravalvular leakage (PVL) is a complication of transcatheter aortic valve implantation (TAVI) for aortic stenosis, leading to an adverse prognosis. We investigated whether aortic valve calcium volume (Ca-Vol) measured by preoperative cardiac computed tomography had a predictive value for PVL after TAVI using a third-generation self-expandable valve. We retrospectively analyzed 59 consecutive patients
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MiR-375 Inhibitor Alleviates Inflammation and Oxidative Stress by Upregulating the GPR39 Expression in Atherosclerosis Int. Heart J. (IF 1.5) Pub Date : 2024-01-31 Hui Luo, Lin Zhao, Bo Dong, Yanghong Liu
Atherosclerosis may be caused or developed by an immune response and antioxidation imbalance. MicroRNA-375 (miR-375) or G-protein-coupled receptor 39 (GPR39) is involved in vascular endothelial cell injury, but their role in atherosclerosis is unknown. This experiment aimed to determine the action of the miR-375/GPR39 axis in atherosclerosis. Human aortic endothelial cells (HAECs) were treated with
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Prognostic Significance of Asymptomatic Cerebral Infarction in Patients After Cardiac Catheterization Int. Heart J. (IF 1.5) Pub Date : 2024-01-31 Kenji Yamaji, Yoshitaka Iwanaga, Kazuyoshi Kakehi, Kosuke Fujita, Takayuki Kawamura, Chikara Hirase, Masafumi Ueno, Gaku Nakazawa
Recent studies have showed that asymptomatic cerebral infarction (ACI) developed in a reasonable number of patients after cardiac catheterization. However, no study has investigated the long-term prognostic impact of ACI after cardiac catheterization. We investigated whether ACI after cardiac catheterization affects long-term mortality and subsequent cardiovascular events. We retrospectively enrolled
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Multimodality Risk Assessment of Patients with Ischemic Heart Disease Using Deep Learning Models Applied to Electrocardiograms and Chest X-rays Int. Heart J. (IF 1.5) Pub Date : 2024-01-31 Shinnosuke Sawano, Satoshi Kodera, Masataka Sato, Hiroki Shinohara, Atsushi Kobayashi, Hiroshi Takiguchi, Kazutoshi Hirose, Tatsuya Kamon, Akihito Saito, Hiroyuki Kiriyama, Mizuki Miura, Shun Minatsuki, Hironobu Kikuchi, Norifumi Takeda, Hiroyuki Morita, Issei Komuro
Comprehensive management approaches for patients with ischemic heart disease (IHD) are important aids for prognostication and treatment planning. While single-modality deep neural networks (DNNs) have shown promising performance for detecting cardiac abnormalities, the potential benefits of using DNNs for multimodality risk assessment in patients with IHD have not been reported. The purpose of this
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Influence of Body Mass Index on the Prognostic Value of N-Terminal Pro-B-Type Natriuretic Peptide Level in Chinese Patients with Heart Failure Int. Heart J. (IF 1.5) Pub Date : 2024-01-31 Lingfang Tian, Xiangkui Li, Jian Zhang, Xinhui Tian, Xiaolei Wan, Dengju Yao, Bin Luo, Qinzhen Huang, Yansong Deng, Wei Xiang
N-terminal pro-B-type natriuretic peptide (NT-proBNP) is an essential biomarker for the prediction of heart failure (HF), but its prognostic ability across body mass index (BMI) categories needs to be clarified. Our study aimed to explore the association between BMI and NT-proBNP and assess the effect of BMI on the prognostic ability of NT-proBNP in Chinese patients with HF. We retrospectively analyzed
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Ivabradine Alleviates Experimental Autoimmune Myocarditis-Mediated Myocardial Injury Int. Heart J. (IF 1.5) Pub Date : 2024-01-31 Manlin Zhu, Jingjing Lu, Xiaomin Li, Yongqiang An, Bohan Li, Wei Liu
Ivabradine (IVA) reduces heart rate by inhibiting hyperpolarization-activated cyclic nucleotide-gated channels (HCNs), which play a role in the promotion of pacemaker activity in cardiac sinoatrial node cells. HCNs are highly expressed in neural and myocardial tissues and are involved in the modulation of inflammatory neuropathic pain. However, whether IVA exerts any effect on myocardial inflammation
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Large Tissue Debris Causing Cerebral Embolism After Transcatheter Aortic Valve Replacement Int. Heart J. (IF 1.5) Pub Date : 2024-01-31 Shunsuke Kagawa, Yoshiki Matsumura, Ryo Matsumoto, Yukio Abe, Aiko Terada, Tomoya Ishiguro, Takahiko Naruko
Cerebral vascular embolism is one of the complications of transcatheter aortic valve replacement (TAVR). Thrombolytic therapy is not expected to be effective when embolic material consists of a large tissue fragment. Instead, mechanical aspiration may be more effective therapy for acute cerebral infarction after TAVR. Here, we describe the case of an 87-year-old woman with aortic valve stenosis and
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A Patient with Partial 17α-Hydroxylase Deficiency Initially Diagnosed with Asherman Syndrome and Pheochromocytoma Int. Heart J. (IF 1.5) Pub Date : 2024-01-31 Hongxiao Yu, Xiping Liu, Zhihua Nie, Yanhua Xia
This study present a case of a 49-year-old woman who suffered from resistant hypertension, hypokalemia, hypomenorrhea, and infertility. She was hospitalized 6 years earlier for hypomenorrhea and abdominal pain at the Xiamen Maternity and Child Health Hospital, where she was diagnosed with Asherman syndrome. During hospitalization, a computed tomography examination revealed an adrenal mass. She was
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Errata: Rare Compound Heterozygous Missense Mutation of the SCN5A Gene with Childhood-Onset Sick Sinus Syndrome in Two Chinese Sisters: A Case Report Int. Heart J. (IF 1.5) Pub Date : 2024-01-31
An error appeared in the article entitled "Rare Compound Heterozygous Missense Mutation of the SCN5A Gene with Childhood-Onset Sick Sinus Syndrome in Two Chinese Sisters: A Case Report" by Yanyun Wang, Siyu Long, Chenxi Wei, and Xiaoqin Wang (Vol. 64 No.2, 299-305, 2023). The name of the first affiliation on page 299 was wrong. It should be "Laboratory of Molecular Translational Medicine, Center for
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Association Between Serum Uric Acid Levels and Neoatherosclerosis An Optical Coherence Tomography Study in Patients with In-Stent Restenosis Int. Heart J. (IF 1.5) Pub Date : 2024-01-31 Ning Gu, Zhijiang Liu, Zhenglong Wang, Changyin Shen, Wei Zhang, Hongqin Tian, Xi Wang, Shuangya Yang, Ranzun Zhao, Bei Shi
Neoatherosclerosis is a major cause of stent failure after percutaneous coronary intervention. Metabolism such as hyperuricemia is associated with in-stent restenosis (ISR). However, the association between serum uric acid (sUA) levels and in-stent neoatherosclerosis (ISNA) has never been validated. A total of 216 patients with 220 ISR lesions who had undergone optical coherence tomography (OCT) of
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Pretransfer Aspirin Administration and Its Impact on Angiographic Outcomes for Patients with ST-Elevation Myocardial Infarction Int. Heart J. (IF 1.5) Pub Date : 2024-01-31 Ryota Yamada, Takeo Horikoshi, Takamitsu Nakamura, Manabu Uematsu, Kazuyuki Yamaguchi, Tsuyoshi Kobayahi, Ryota Ando, Toru Yoshizaki, Yosuke Watanabe, Kenji Kuroki, Kazuto Nakamura, Akira Sato
Although guidelines recommend early aspirin administration after diagnosis of ST-elevation myocardial infarction (STEMI), the decision of pretransfer aspirin administration is at the discretion of the primary physicians. Therefore, this study aimed to determine whether pretransfer aspirin administration was associated with better angiographical outcomes in patients with STEMI. This study compared the
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Association Between Atherogenic Index of Plasma and Risk of Incident Major Adverse Cardiovascular Events Int. Heart J. (IF 1.5) Pub Date : 2024-01-31 Yao-Wei Zhi, Run-Gui Chen, Ji-Wei Zhao, Shu-Xuan Zhou, Zhi-Jie He
It is unclear whether the atherogenic index of plasma (AIP) is associated with major adverse cardiovascular events (MACEs) in the general population. A total of 361,644 participants (aged 56.19 ± 8.09 years; 44.79% male) free of a history of MACEs at baseline from the UK Biobank data were included in the analysis. The AIP was calculated using log (triglyceride/high-density lipoprotein-cholesterol)
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Postmortem Identification of Genetic Variations Associated with Sudden Unexpected Death in Young People Int. Heart J. (IF 1.5) Pub Date : 2024-01-31 Aya Miura, Takuma Yamamoto, Kazuhisa Funayama, Akihide Koyama, Hisakazu Takatsuka, Takako Sato, Hajime Nishio
Sudden unexpected death in the young (SUDY) is a traumatic occurrence for their family; however, information on the genetic variations associated with the condition is currently lacking. It is important to carry out postmortem genetic analyses in cases of sudden death to provide information for relatives and to allow appropriate genetic counselling and clinical follow-up. This study aimed to investigate
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Electromyogram Power Spectrum and Cardiac Function Changes After Combined Aerobic Interval Training and Inspiratory Muscle Training in Chronic Heart Failure Patients Int. Heart J. (IF 1.5) Pub Date : 2024-01-31 Zahra Sadek, Wiam Ramadan, Said Ahmaidi, Mahmoud Youness, Wissam H Joumaa
Exercise intolerance and dyspnea are the major symptoms of patients with chronic heart failure (CHF) and are associated with a poor quality of life. In addition to impaired central hemodynamics, symptoms may be attributed to changes in peripheral skeletal muscles. This study aimed to evaluate the effects of aerobic interval training (AIT) combined with inspiratory muscle training (IMT) on cardiac and
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Calcium-Phosphorus Product Is Associated with Adverse Prognosis in Hospitalized Patients with Heart Failure and Chronic Kidney Disease Int. Heart J. (IF 1.5) Pub Date : 2024-01-31 Satoshi Abe, Akiomi Yoshihisa, Himika Oohara, Yukiko Sugawara, Yu Sato, Tomofumi Misaka, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Kazuhiko Nakazato, Yasuchika Takeishi
It has been reported that high levels of calcium-phosphorus (Ca-P) product are an indicator of coronary calcification and mortality risk in patients undergoing chronic hemodialysis. In the present study, we aimed to evaluate the significance of Ca-P product to predict the prognosis of patients with heart failure (HF) and chronic kidney disease (CKD). We conducted a prospective observational study of
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Comparison of Characteristics and Outcomes Between Acute Ischemic Stroke Patients with Different Types of Heart Failure Int. Heart J. (IF 1.5) Pub Date : 2024-01-31 Jiongxing Wu, Mingxi Chen, Huan Wang, Yuyi Zhu, Yaqi Chen, Shihong Zhang, Deren Wang
Acute ischemic stroke (AIS) can be complicated by heart failure involving preserved ejection fraction (HFpEF) or reduced ejection fraction (HFrEF), and whether or not the prognosis differs between the 2 types of patients remains unclear. We compared the clinical characteristics and outcomes of the 2 types of patients at 3 months after the stroke. We retrospectively analyzed patients who, between 1
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Feedbacks Using behaviOral econOmic theories on STEP countS in Cardiovascular Disease Patients (FOOTSTEPS) Using Novel Daily Step Counts Retrieving System A Pilot Study Int. Heart J. (IF 1.5) Pub Date : 2024-01-31 Takahiro Suzuki, Jeff Rewley, Keiko Sugibuchi, Yoko Suzuki, Sachiko Suzumura, Nanami Tsurugi, Daisuke Okamura, Koichi Node, Atsushi Mizuno
The effectiveness of gamification-based feedback systems that utilize non-monetary points to promote exercise among cardiovascular disease (CVD) patients has not been fully evaluated. This study aimed to evaluate the effectiveness of a gamification program using non-monetary points on the daily step counts in CVD patients. We collected 30 patients with a history of heart failure or myocardial infarction
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Astaxanthin Alleviates the Process of Cardiac Hypertrophy by Targeting the METTL3/Circ_0078450/MiR-338-3p/GATA4 Pathway Int. Heart J. (IF 1.5) Pub Date : 2024-01-31 Kelian Zhang, Huilin Zhuo, Jingyi Guo, Wei Wang, Ruozhu Dai
Astaxanthin (ASX) is a natural antioxidant with preventive and therapeutic effects on various human diseases. However, the role of ASX in cardiac hypertrophy and its underlying molecular mechanisms remain unclear. Cardiomyocytes (AC16) were used with angiotensin-II (Ang-II) to mimic the cardiac hypertrophy cell model. The protein levels of hypertrophy genes, GATA4, and methyltransferase-like 3 (METTL3)
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Feasibility Study of a Novel Transapical Chordal Implantation System in a Porcine Model Int. Heart J. (IF 1.5) Pub Date : 2024-01-31 Yuntao Lu, Jinmiao Chen, Minyan Yin, Ye Yang, Wenshuo Wang, Lili Dong, Wenyu Song, Jian Meng, Qingliang Zhou, Lai Wei
Transapical beating-heart mitral repair with chordal implantation system has been considered as an alternative treatment for degenerative mitral regurgitation. This study aimed to assess the feasibility and safety of the E-Chord system (Med-Zenith Medical, Beijing, China) for transapical beating-heart mitral valve repair in a porcine model. Artificial chordae were transapically implanted on the mitral
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Is Moderate/Large Residual Shunt After PFO Closure Justifiable for a Patient with a Prior History of Cryptogenic Stroke and Transient Ischemic Attack? Int. Heart J. (IF 1.5) Pub Date : 2024-01-31 Francesco Melillo, Gregory Popusoi, Francesca Frecentese, Vittoria Miano, Alessandro Santoro, Tullio Tesorio, Eustaquio Maria Onorato
A 36-year-old woman suffered from an embolic stroke of an undetermined source documented by magnetic resonance imaging with residual right arm weakness. She underwent percutaneous patent foramen ovale (PFO) closure with an 18/25 mm device in another center. One year later, the patient suffered from a transient ischemic attack with dysarthria. She asked for a second opinion at our institution and a
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A Surgical Case of Partially Unroofed Coronary Sinus Atrial Septal Defect in an Elderly Patient Diagnosed by Preoperative Contrast-Enhanced Computed Tomography Int. Heart J. (IF 1.5) Pub Date : 2024-01-31 Norihisa Yuge, Susumu Manabe, Daiki Hirayama, Ryuki Yamada, Mariko Hori, Tomohiro Saito, Nobuhiro Mochizuki, Koichiro Sugimura, Hiroaki Shimokawa
Unroofed coronary sinus syndrome is a rare congenital cardiac anomaly, involving some anatomical variations. Approximately 60% of patients with unroofed coronary sinus syndrome have a concomitant atrial septal defect, which is termed unroofed coronary sinus atrial septal defect (CSASD). The precise detection of these abnormalities has been usually difficult with conventional echocardiography, mostly
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Effect of Comprehensive Psychological Intervention on Negative Emotions and Quality of Life in Patients with Acute Myocardial Infarction Int. Heart J. (IF 1.5) Pub Date : 2023-11-30 Fei Hou, Tong Xie, Yulin Xi, Wenli Qian, Xiaoyan Liu
Although acute myocardial infarction (AMI) currently has a high survival rate, the treatment and prognosis are still diffuse negative life events for patients, which will affect their quality of life (QOL) and psychological health. Based on an integrated physiological-psychological-social-medical model, it is necessary to design an intervention program for safeguarding the physical and mental health
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Investigation of Stroke Risk Factors and Prognostic Indicators in NVAF Patients with Low CHA2DS2-VASc Scores Int. Heart J. (IF 1.5) Pub Date : 2023-11-30 Tang-Gang Gao, Feng Gao, Wei-Bin Huang, Jia-Yi Cai, Hui-Li Yang, Chen-Chun Xiong, Yang Ruan, Sui-Feng Liu
The prognosis of patients with nonvalvular atrial fibrillation (NVAF) with a low CHA2DS2-VASc score (0-1) following a stroke is not well studied. In this investigation, stroke risk factors and prognostic markers in low-risk NVAF patients who are nonetheless at risk for stroke were examined. From January 2012 to January 2022, we retrospectively assessed atrial fibrillation (AF) patients at Xiamen University's
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Characteristics of Discharged Elderly Patients with Acute Heart Failure Followed by Board-Certified-Cardiologists in a Rural Area of Japan Int. Heart J. (IF 1.5) Pub Date : 2023-11-30 Keisuke Satogami, Yosuke Katayama, Yuichi Ozaki, Akira Taruya, Motoki Taniguchi, Shingo Ota, Akio Kuroi, Yasutsugu Shiono, Takashi Tanimoto, Takashi Yamano, Hironori Kitabata, Yasushi Ino, Atsushi Tanaka
The worldwide incidence rates of heart failure (HF) are approaching pandemic status due to aging societies. Board-certified cardiologists (BCCs) of the Japanese Circulation Society (JCS) are cardiologists who have completed the respective fellowship program and passed the examination. However, in rural areas, patients have limited access to medical care for social or geographical reasons. The clinical
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The Correlation of Inflammation, Oxidative Stress, and Hippocampal Perfusion in Patients with Atrial Fibrillation Int. Heart J. (IF 1.5) Pub Date : 2023-11-30 Jin-yi Li, Gui-cheng Liang, Fu-ling Huang, Shi-rong Wang, Shu-hu Li, Hong-hong Ke
Atrial fibrillation (AF) is closely related to abnormal cerebral blood flow. Inflammation and oxidative stress have always been important factors in the pathophysiology of AF. It remains unknown whether inflammation and oxidative stress are correlated to hippocampal perfusion in patients with AF. Sixty-three patients with AF with normal hippocampal blood perfusion (NHBP) were compared to 71 patients
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Identification of the Key Genes of Immune Infiltration in Dilated Cardiomyopathy Int. Heart J. (IF 1.5) Pub Date : 2023-11-30 Bin Qi, Hai-Yan Wang, Xiao Ma, Yu-Feng Chi, Chun Gui
Dilated cardiomyopathy (DCM) is a common cause of heart failure. In this study, we screened the immune infiltration-related genes associated with DCM to explore the potential molecular mechanisms and provide a basis for the early diagnosis and development of new immunotherapeutic targets. A dataset related to DCM was downloaded from the Gene Expression Omnibus (GEO) database. R software was applied
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Financial Implication of Sodium Zirconium Cyclosilicate Therapy in Patients with Systolic Heart Failure and Hyperkalemia Int. Heart J. (IF 1.5) Pub Date : 2023-11-30 Teruhiko Imamura, Nikhil Narang, Koichiro Kinugawa
Sodium zirconium cyclosilicate (SZC), a newly-introduced potassium binder, can be used to manage hyperkalemia especially in patients with chronic kidney disease and in those on medical therapy which may raise serum potassium levels. The medication may incur additional costs but may in turn have a significant benefit in the effect of maintaining guideline-directed medical therapy for heart failure.
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Longitudinal Changes in Natriuretic Peptides and Reverse Cardiac Remodeling in Patients with Heart Failure Treated with Sacubitril/Valsartan Across the Left Ventricular Ejection Traction Spectrum Int. Heart J. (IF 1.5) Pub Date : 2023-11-30 Masayoshi Yamamoto, Tomoko Ishizu, Kimi Sato, Kentaro Minami, Taikan Terauchi, Tomofumi Nakatsukasa, Naoto Kawamatsu, Tomoko Machino-Ohtsuka, Masaki Ieda
Sacubitril/valsartan improves outcomes in patients with heart failure (HF) with reduced ejection fraction. However, the relationship between longitudinal changes in natriuretic peptides and echocardiographic parameters in patients with HF treated with sacubitril/valsartan across the left ventricular ejection fraction (LVEF) range is not fully understood. In patients with HF treated with sacubitril/valsartan
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Circ-SUZ12 Protects Cardiomyocytes from Hypoxia-Induced Dysfunction Through Upregulating SUZ12 Expression to Activate Wnt/β-catenin Signaling Pathway Int. Heart J. (IF 1.5) Pub Date : 2023-11-30 Long Li, Chao Li, Shuai Cao, Gaoliang Zhou, Yongjin Jiang, Jun Feng
Acute myocardial infarction (AMI) is a common coronary artery disease. This study attempted to reveal the impact of circ-SUZ12 (hsa_circ_0042961) on cardiomyocyte injury after exposure to hypoxia. Circ-SUZ12 was screened out from the GEO dataset GSE169594. RNA expression and protein level were detected by quantitative real-time PCR (qRT-PCR) and Western blot, respectively. The characteristics of circ-SUZ12
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UEDA Heart Awards for 2023 Int. Heart J. (IF 1.5) Pub Date : 2023-11-30
We are pleased to announce that the following 3 articles have been selected for the UEDA Heart Awards for the Year 2023. FIRST PLACE Atherosclerotic Progression Is Related to Immune-Related Adverse Events Atsumasa Kurozumi, Kayo Sakamoto, Takashi Nakagawa, Futoshi Matsunaga, Akihiko Shimomura, Chikako Shimizu, Hisao Hara, Yukio Hiroi Int Heart J 2022; 63 (2): 293-298. SECOND PLACE Functional Evaluation
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Development and Validation of a Novel Model for Predicting Coronary Heart Disease in Snoring Hypertensive Patients with Hyperhomocysteinemia Int. Heart J. (IF 1.5) Pub Date : 2023-11-30 Jianwen Zhao, Menghui Wang, Nanfang Li, Qin Luo, Ling Yao, Xintian Cai, Na Yue, Yingli Ren, Guoliang Wang
Hypertensive patients with snoring and elevated plasma homocysteine levels are common. When these factors are combined, the risk of coronary heart disease (CHD) is high. Herein, we developed and validated an easy-to-use nomogram to predict high-risk CHD in snoring hypertensive patients with elevated plasma homocysteine. Snoring patients (n = 1,962) with hyperhomocysteinemia and hypertension were divided
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Supra-Normal Left Ventricular Ejection Fraction as a Prognostic Marker for Long-Term Outcomes in Patients with Acute Coronary Syndrome Int. Heart J. (IF 1.5) Pub Date : 2023-11-30 Baona Li, Liuxin Chen, Man Zheng, Pengcheng Yan, Leiyan Wang, Shuai Feng, Wenchao Yin, Kevin Zhang, Shaohui Zhang, Xueying Chen, Zhaoyang Wang, Haitao Yuan
Recently, the supra-normal left ventricular ejection fraction (snLVEF) has been proposed, based on extensive datasets indicating increased all-cause mortality in individuals with an LVEF exceeding 65%. However, the implications of an LVEF > 65% in the context of acute coronary syndrome (ACS) remain underexplored. The aim of the present study was to investigate the correlation between supra-normal left
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Proposal for a Display Method for Myocardial Single Photon Emission Computed Tomography Based on Left Ventricular Volume Int. Heart J. (IF 1.5) Pub Date : 2023-11-30 Keiko Takahashi, Teishi Kajiya, Masaharu Ishihara
Bull's eye view for the display of myocardial single-photon emission computed tomography (SPECT) 3-D perfusion maps does not reflect left ventricular (LV) volume, an important parameter. We created and evaluated a myocardial SPECT display method that reflects the LV volume. Using Digital Imaging and Communications in Medicine data, short-axis slices from the apex to the base were reconstructed and
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Association of Dietary Magnesium Intake with the Risk of Stroke among Adults NHANES 2007-2018 Int. Heart J. (IF 1.5) Pub Date : 2023-11-30 Peng Sun, Zhiqiang Wang, Bo Li, Shanjiang Chen
The relationship between dietary magnesium intake and the risk of stroke is controversial. This study aimed to examine the association of dietary magnesium intake with the risk of stroke among American adults. The relationship between dietary magnesium intake and the risk of stroke was analyzed using the National Health and Nutrition Examination Survey (NHANES) 2007-2018 data with 29,653 adults. The
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The Prognostic Value of Blood Urea Nitrogen to Albumin Ratio on Patients with Heart Failure Int. Heart J. (IF 1.5) Pub Date : 2023-11-30 Li Zhao, Yijun Liu, Zhen Tan, Mei Zhang, Shuang Li, Guiquan Luo, Hongqiang Ren
This study aimed to investigate the relationship between blood urea nitrogen to albumin ratio (BAR) and the prognosis of heart failure (HF). A total of 2125 patients with HF were included in this single-center prospective cohort study between February 2012 and December 2017. Using a receiver operating characteristic curve, we determined the cutoff value of BAR as 0.24. All patients were divided into