-
Exophytic proliferative nodule on the scalp of a child Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-04-18 Namrata Sarkar, Siddhartha Dash, Biswanath Behera, Madhusmita Sethy, Pavithra Ayyanar
-
Application of dermoscopy and reflectance confocal microscopy in vivo in the evaluation of nevi in children Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-04-18 Anna Pogorzelska‐Antkowiak, Salvador Gonzalez
BackgroundMelanocytic nevi are frequently observed in the pediatric population. While newly acquired nevi can appear during childhood, congenital nevi can continue to grow and clinically change, making patient caregivers concerned. Reflectance confocal microscopy (RCM) in vivo is a noninvasive tool that might enhance the diagnostic accuracy of dermoscopy, reducing the rate of unnecessary surgical procedures
-
Prostaglandin E‐induced polycyclic cutaneous eruption with geometric features Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-04-18 Ananya Shah, Jinia El‐Feghaly, Alexandra M. Bender
Prostaglandin E1 (PGE1) is a substance produced by the patent ductus arteriosus that keeps it open. PGE1 can be a lifesaving drug for infants born with ductus‐dependent congenital heart disease (CHD) where there is a block of blood flow to the lungs or transposition of great arteries. We present a case of a 36‐week, 2‐day gestation neonate with CHD who developed bright erythematous annular and polycyclic
-
Regimen for accelerated propranolol initial dosing (RAPID) Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-04-17 Charles Y. Huang, Marissa J. Perman, Albert C. Yan
BackgroundInfantile hemangiomas are common vascular tumors in children. Propranolol has proven effective in treating infantile hemangiomas and while generally safe, has potential risk for more serious side effects of hypoglycemia, hypotension, bradycardia, bronchospasm, and cardiovascular or respiratory compromise. Current prescribing guidelines recommend initiating propranolol doses at 1 mg/kg/day
-
Dupilumab treatment of trichothiodystrophy in a child Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-04-17 Elisabetta Magnaterra, Mattia Giovannini, Cesare Filippeschi, Fausto Andrea Pedaci, Greta Tronconi, Michele Callea, Silvia Ricci, Francesca Mori, Maria Parpagnoli, Teresa Oranges
Trichothiodystrophy (TTD) is a rare congenital disorder caused by genetic mutations, leading to hair and skin abnormalities. We report successful treatment of a TTD case using dupilumab, a monoclonal antibody targeting IL‐4Rα. The patient, a 7‐year‐old boy, exhibited significant improvement in skin and hair conditions, suggesting the potential of dupilumab as a therapeutic option for TTD. Further research
-
Large, ulcerated infantile hemangioma of the chest wall complicated by life‐threatening hemorrhage: Case report and literature review Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-04-17 Elaine Dong, Edgar D. Rodriguez, Carla I. Levin, Gregory C. Gardner, Denise W. Metry
While ulceration is one of the most common infantile hemangioma (IH) complications, severe bleeding is a rare consequence, with a paucity of patients reported. We report a 5‐month‐old girl with a very large, mixed, partial segmental IH of the upper chest wall who, despite medical intervention, developed severe ulceration and multiple episodes of life‐threatening bleeding that ultimately led to hemorrhagic
-
Widespread eruption after blood transfusion during phototherapy in a newborn Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-04-17 Umit Ayse Tandircioglu, Serdar Alan
-
Post‐streptococcal small‐vessel vasculitis in a 16‐month‐old with associated intussusception and hypertension: Henoch Schönlein purpura? Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-04-17 Sara Banbury, David M. Milgraum, Daniel J. Lewis, Maria Queenan, James R. Treat
Henoch Schönlein purpura (HSP), also known as IgA vasculitis, is a systemic small‐vessel vasculitis typically occurring in children 3–15 years of age, with peak incidence at 4–6 years. It is characterized by a constellation of symptoms including palpable purpura, arthralgias or arthritis, abdominal pain including intussusception, and renal involvement. We report a patient with these clinical findings
-
A 10‐year‐old girl with gray‐brown patches in the axillary and inguinal folds Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-04-16 Dirk Van Gysel, Hannelore De Maeseneer, Hanne Locy, Ramses Forsyth, Sherief R. Janmohamed
-
The diagnostic difficulties of juvenile vulvar pemphigoid Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-04-16 Sophie Gart, Ritu Swali, Erica B. Lee, Nicole Harter
Mucous membrane pemphigoid is a rare autoimmune disease affecting mucosal surfaces. Pediatric cases are exceptionally rare, one subtype being vulvar pemphigoid. Juvenile vulvar pemphigoid can be challenging to diagnose due to its rarity and subtle initial symptoms. We present a case of an 8‐year‐old girl successfully diagnosed early in the disease course via histopathology, and immunofluorescence.
-
Dermatologic needs of transgender and gender diverse youth: A retrospective cohort study Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-04-16 William Butler, Casey R. Cai, Jeremi M. Carswell, Jennifer T. Huang
Several dermatologic concerns are known to disproportionally affect transgender and gender‐diverse (TGD) adults, but little is known about dermatologic conditions in TGD youth. This study assesses the prevalence of acne, androgenic alopecia, scarring from gender‐affirming procedures, and eczema in pediatric TGD patients seen at Boston Children's Hospital between April 2021 and April 2022. The results
-
Phacomatosis pigmentokeratotica: Exploring extracutaneous comorbidities and topical therapy Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-04-15 Gemma Camiña‐Conforto, Marta Ivars, Georgia Sarquella‐Brugada, Carlos Valera‐Dávila, Héctor Salvador, Carlota Rovira, Eulalia Baselga
Phacomatosis pigmentokeratotica (PPK) is a RASopathy characterized by the presence of a sebaceous nevus and a papular speckled lentiginous nevus. This case report highlights the associated extracutaneous comorbidities, including life‐threatening arrhythmia, and introduces topical rapamycin as a potential therapeutic avenue for sebaceous nevus in PPK patients.
-
Complex cutaneous leishmaniasis in a pediatric patient Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-04-15 Ramneek K. Dhami, Megha M. Tollefson, Jackson G. Turbeville
Cutaneous leishmaniasis (CL), a parasitic infection caused by Leishmania protozoa and transmitted by sandfly bites, can be classified into Old World and New World subtypes. We report a case of a 2‐year‐old female who developed complex CL after travel to Panama. Ultimately, successful treatment required two rounds of liposomal amphotericin B. We report this case for its challenging clinical course and
-
Violaceous plaque with lower limb paresis in an adolescent male Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-04-15 Bhat Kriti, Anupama Bains, Utkrist Lahoria, Ananya Panda, Sudeep Khera
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest.
-
A plantar subcutaneous nodule in a healthy infant Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-04-02 Luca Borg, Daniel Micallef, Alexandra Betts, Michael J. Boffa
CONFLICT OF INTEREST STATEMENT The authors have no conflicts of interest and no funding sources to declare.
-
Plexiform neurofibroma masquerading as a giant congenital melanocytic nevus Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-04-02 Gerilyn M. Olsen, Dawn H. Siegel, Olayemi Sokumbi, Yvonne E. Chiu
A 4‐month‐old male presented for a large, hypertrichotic brown patch on the upper back with several scattered 0.5–1.5 cm, round to oval, brown macules and patches on the trunk and extremities. The lesion was initially diagnosed as a giant congenital melanocytic nevus based on clinical exam and histopathology with immunohistochemical stains. The patient was later diagnosed with neurofibromatosis type
-
Bone marrow transplantation and bone marrow‐derived mesenchymal stem cell therapy in epidermolysis bullosa: A systematic review Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-04-01 Maulidina Agustin, Anita Mahadewi, Retno Danarti
Epidermolysis bullosa (EB) is a genodermatosis that lacks effective treatments and requires supportive care for its severe, life‐threatening manifestations. Bone marrow transplantation (BMT) and its derived cells have been suggested to improve clinical symptoms and quality of life. A comprehensive search was conducted for publications evaluating BMT and bone marrow‐derived mesenchymal stem cell (BM‐MSC)
-
Topical everolimus therapy for epidermal nevi associated with woolly hair nevus in a patient with a mosaic HRAS mutation Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-04-01 Akaljot Singh, Emily S. Gorell, Anne W. Lucky
A patient with woolly hair nevus syndrome, presented with epidermal facial nevi by the age of 12 years. Despite transient improvement with topical 1% sirolimus cream, the facial nevus grew larger. The patient was then treated with topical 1% everolimus cream resulting in a reduction in the size of the nevus. This case highlights a novel use of topical 1% everolimus cream, which previously has not been
-
Single dominant lesion in capillary malformation‐arteriovenous malformation (CM‐AVM) RASA1 syndrome Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-04-01 Luis Fernando Sánchez‐Espino, Marta Ivars, Carolina Prat Torres, Cinzia E. Lavarino, Nagore Gené Olaciregui, Carlota Rovira Zurriaga, Verónica P. Celis Passini, Miguel Bejarano Serrano, Eulàlia Baselga
We report two cases with localized vascular malformations clinically resembling the “dominant lesion” seen in capillary malformation‐arteriovenous malformation (CM‐AVM) syndrome, however, lacking germline RASA1 variants but presenting double somatic RASA1 variants in affected tissue. Both patients presented with localized and superficial high‐flow vascular malformations were treated with surgery and
-
Lymphoplasmocytic plaque in children: A report of an atypical location Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-04-01 João Teixeira, Sofia Pereira, Joana Resende Xará, José Carlos Cardoso, Leonor Ramos
Lymphoplasmocytic plaque in children (LPC) is a rare and distinctive skin disorder primarily affecting the pediatric population. Characterized by its unique histopathological features, the condition manifests as well‐defined plaques with a predominance of lymphocytes and plasma cells infiltrating the dermis. Despite its limited prevalence, recognizing this entity is crucial for accurate diagnosis and
-
A survey assessment of combined pediatric dermatology–rheumatology clinics Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-03-27 Olga S. Cherepakhin, Sarah Ringold, Tova Ronis, A. Yasmine Kirkorian, Heather Brandling‐Bennett
The expertise of both dermatology and rheumatology may be beneficial when managing autoimmune conditions with cutaneous and systemic manifestations in children. This survey study was directed to pediatric dermatologists who participate in combined pediatric dermatology–rheumatology clinics; 13 sites in North America responded. The results provide information regarding clinic operations, benefits, and
-
Comparison of the Skindex‐Teen and the Skindex‐29 quality of life survey instruments in a predominantly American Indian adolescent population Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-03-27 Micah G. Pascual, Sarah J. Schmiege, Spero M. Manson, Lucinda L. Kohn
Background/ObjectivesThe Skindex‐29 and Skindex‐Teen assess dermatology‐related quality of life among adults and adolescents, respectively. This study directly compared the same adolescents' responses to the Skindex‐29 relative to Skindex‐Teen in a predominantly American Indian and/or Alaska Native population. This population is underrepresented in medical research. Although skin‐related quality‐of‐life
-
Painless bleeding in a 4‐year‐old boy Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-03-26 Debdeep Mitra, Karthi Kishore, Siva Chaitanya Senapathi
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest.
-
An enlarging ulcerative nodule Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-03-26 Steffany Poupart, Jerome Coulombe
CASE PRESENTATION A healthy 9-year-old girl, with no past medical history, presented with a 10-day history of a rapidly enlarging, ulcerated 2-cm nodule on her left temple (Figure 1). On further physical examination, a 5-mm papule on her right thigh (Figure 2), scattered millimeter-sized pink papules, and an atrophic scar on her left thigh were noted. Mucosae were spared, and no enlarged lymph nodes
-
Scrofuloderma of the chest with mediastinal TB Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-03-22 Vanessa Bustamante Estrada, Ana Claudia Lada Lemos, Pedro Machado Luz, Iara Regina Siqueira Lucena, Valentina Coutinho Baldoto Gava Chakr, Anneliese Hoffmann
Cutaneous tuberculosis is a rare manifestation of extrapulmonary tuberculosis caused by Mycobacterium tuberculosis in most cases and rarely by Mycobacterium bovis. Diagnosis may be challenging due to a wide range of clinical findings and similarities to other chronic dermatoses, leading to delayed treatment. We present a case of scrofuloderma in a 4‐year‐old girl that arose from a contiguous spread
-
Seeking shade equity: Tree canopy coverage in public schools in Austin, TX Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-03-20 Georgia E. Williams, Dayna G. Diven
Background/ObjectivesTree canopies have dermatologic and environmental benefits, especially on school campuses. However, inequities likely exist, and tree planting initiatives may further exacerbate disparities. We sought to identify any relationship between tree canopy shade on public school campuses in Austin, TX and the socioeconomic makeup of the student population, as well as whether current initiatives
-
Dermatology Life Quality Index survey in patients with Down syndrome and caregivers Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-03-19 Morgan Dykman, Madison Ernst, Tasya Rakasiwi, Amy Buros Stein, David J. Satin, Kristen E. Holland, Stephanie L. Santoro, Jillian F. Rork
Down syndrome (DS) is associated with many dermatological conditions, including hidradenitis suppurativa, folliculitis, and alopecia areata. Despite the high incidence of skin conditions in this population, there are no quality of life (QoL) studies in the dermatology literature focused on patients with DS or their caregivers. The frequently used QoL assessment tool, the Dermatology Life Quality Index
-
The occurrence of mental health symptoms in isotretinoin‐treated adolescents Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-03-19 Keith Miller, Alastair McKean, Jennifer Hand, Sandra Rackley, Jonathan G. Leung, Allison LeMahieu, Jennifer Geske, J. Michael Bostwick
BackgroundIsotretinoin treatment for acne can reduce adverse psychiatric outcomes in adults, but there has been little investigation of the incidence of psychiatric outcomes in treated adolescents.MethodsThis retrospective cohort study using the Rochester Epidemiology Project identified 606 patients aged 12–18 prescribed isotretinoin over a 10‐year period between January 1, 2008 and December 31, 2017
-
Dermoscopy of hypopigmented macules unveiling genetic diagnosis of tuberous sclerosis complex type 2 in an infant presenting with sacral chordoma Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-03-19 Ananya Sharma, Bhawana Aggarwal, Aanchal Kakkar, Niraj Nirmal Pandey, Neha Taneja
A 2‐month‐old male with surgically resected sacral chordoma presented with multiple hypopigmented macules showing characteristic patchy, sharply demarcated areas of pigment network on dermoscopy. These dermoscopic findings were suggestive of the ash‐leaf macules of tuberous sclerosis over other common hypopigmented macules in neonates. Chordomas presenting in early childhood in the sacral location
-
Chest wall bruising from 5‐point car seat harness as a mimicker of child abuse Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-03-19 Jordan K. Bui, Pyae Naing, Phillip H. Cathers, Mizna Ahmad, Bernard Cohen
Bruising rarely presents in infants younger than 9 months who are not ambulatory and is more prevalent among children beginning to walk, or “cruisers.” We present the case of a healthy 3‐month‐old infant with asymptomatic, symmetric, bilateral, large bruises on the bony chest sparing the mid‐chest/sternum with a negative non‐accidental trauma work‐up. The noted pattern of bruises matched the bilateral
-
Melanoma‐like features in pediatric longitudinal melanonychia: A systematic review and meta‐analysis Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-03-19 Serena Yun‐Chen Tsai, Claire E. Hamilton, Mia A. Mologousis, Elena B. Hawryluk
BackgroundPediatric longitudinal melanonychia (LM) can exhibit atypical features that mimic red‐flag signs for subungual melanoma in adults and lead to diagnostic uncertainty. Nail biopsy may be unnecessary if clinical inspection and dermoscopy suggest a benign nature.MethodsWe searched PubMed and Embase from inception to February 2023 for studies of any design reporting either the number or proportion
-
Letter to the Editor regarding “Cutis marmorata telangiectatica congenita: Incidence of extracutaneous manifestations and a proposed clinical definition” Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-03-18 Vaidehi Dedania, Francine Blei
-
Comment on “Evaluation of a paraffin‐based moisturizer in children with atopic dermatitis: A double‐blind, randomized controlled trial” Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-03-18 Loren E. Hernandez, Lawrence A. Schachner
-
BASCULE syndrome: Additional evidence for the association with autonomic dysfunction Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-03-18 Didier Bessis, Céline Devoye, Nicolas Molinari, Isabelle Quéré, Grégoire de La Villéon, Éric Jeziorski
-
-
What are congenital melanocytic nevi? Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-03-18
Congenital melanocytic nevi (CMN) are special types of moles. CMN happen when extra pigment‐making cells (melanocytes) grow in a baby's skin while the baby is forming before birth. They are not caused by anything their parent did or didn’t do during pregnancy. These moles are there when the baby is born, stay on the skin for life, and grow as the child grows.
-
¿Qué son nevos melanocíticos congénitos? Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-03-18
Los nevos melanocíticos congénitos (NMC) son un tipo especial de lunares. Los NMC ocurren cuando las células que hacen los pigmentos (melanocitos) crecen en exceso en la piel de un feto en formación antes de nacer. No son causados por nada que la madre haya hecho ni haya dejado de hacer durante el embarazo. Estos lunares ya están allí cuando el bebé nace, se mantienen en su piel de por vida y aumentan
-
Distal toxic acral erythema and mucositis secondary to 6‐mercaptopurine in a thiopurine methyltransferase “super shunter” Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-03-14 Sydney Smith, Daniel Grove
Toxic erythema of chemotherapy is a broad but useful diagnosis used to summate the non‐infectious, non‐allergic, and reproducible reaction of certain chemotherapeutics. Due to overlapping chemotherapy side effects and often multiple drug exposures, identification of a singular culprit drug is challenging for dermatologists. Herein, we report a patient with 6‐mercaptopurine (6‐MP) toxic erythema confirmed
-
Neonatal nasal necrosis: Case series and brief review Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-03-09 Jamie L. Karch, David Grand, Ariana G. Diaz, Leah Belazarian, Julianne A. Mann
There is limited information available on pressure‐related neonatal nasal injuries. We present three neonates born with erythema and purpura of the nasal tip that subsequently ulcerated, then evolved into a thick eschar. Each healed well with conservative management but left behind significant scarring. The sharp demarcation and location of the lesions were suggestive of hypoxic tissue damage akin
-
Diffuse neurofibroma with hypertrichosis in a toddler Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-03-09 Robert P. Bower, Paul Leiphart, Thomas Samson, Klaus F. Helm, Andrea Zaenglein
Diffuse neurofibroma is a rare type of neurofibroma uncommonly reported in infancy. It is a slow growing tumor originating in the peripheral nerve sheath. We present the case of a 17‐month‐old boy with diffuse neurofibroma of the scalp associated with hypertrichosis. His genetic and clinical workup for neurofibromatosis was negative.
-
Eye and lid involvement as an uncommon feature of pemphigus foliaceus in a pediatric patient Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-03-09 Valeria F. Garza‐Dávila, Adalberto Santana‐Gutiérrez, Natalia Zapata‐Salazar, Osvaldo Vázquez‐Martínez, Jorge Ocampo‐Candiani, Marissa L. Fernández‐de Luna, Karim Mohamed‐Noriega, Erika Alba‐Rojas
Pemphigus foliaceus (PF) is an autoimmune blistering disorder which affects the superficial layers of the epidermis with rare mucosal involvement. We present the case of a 12‐year‐old girl with PF involving the eyes and eyelids. A literature review of pediatric nonendemic PF revealed another two cases with ocular manifestations. Eyelid involvement is an uncommon feature of PF that should be properly
-
Angiolymphoid hyperplasia with eosinophilia and Kimura disease: A case report and literature review Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-03-09 Elizabeth Botto, Paul Rodriguez‐Waitkus, Sharon E. Albers
Angiolymphoid hyperplasia with eosinophilia (ALHE) is a benign vascular proliferative condition, typically presenting as subcutaneous nodules in the head and neck region of middle‐aged women. Kimura disease (KD) is a benign condition that presents with subcutaneous nodules in a similar distribution with lymphadenopathy and eosinophilia, typically in Asian adult males. These diseases are often discussed
-
“Our Hair, Our Strength, Our Identity”: Native American reflections and what dermatologists can learn Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-03-09 Dante Rangel, Evan Choate, Yolandra Toya, Anthony Fleg, Aimee C. Smidt
Issues of health equity are rightfully in the national spotlight. Here we present a narrative piece on the sacred importance of hair and its ties to cultural identity among many Native communities in the United States. We introduce unique values ascribed to hair in some Native cultures, and include examples of how hair has played an important role in both abuse and generational trauma for many individuals
-
Closing the gap: Enhancing quality pediatric dermatologic care through project Extension for Community Healthcare Outcomes (ECHO) Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-03-08 Travis Jackson, Megan Mosca, Bin Ge, Jonathan Dyer, Kara Braudis, Karen Edison, Mirna Becevic
This study focused on evaluating Extension for Community Healthcare Outcomes (ECHO) participating primary care clinician's (PCC's) diagnostic and treatment accuracy of pediatric dermatologic conditions. To evaluate this, pediatric cases presented to Dermatology ECHO by PCCs with questions regarding diagnosis, treatment regimen, or both were analyzed. After PCC case presentation, the hub team of dermatologists
-
Two siblings with uncombable hair syndrome: A new pathogenic variant Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-03-08 Carlos Calvo‐Asín, Sara I. Palencia‐Pérez, Juan F. Quesada‐Espinosa, Jose Puig‐Buendia, Raquel Cavestany‐Rodríguez, Virginia Velasco‐Tamariz
Two siblings presented with straw‐colored, frizzy, and wiry hair. They had no associated abnormalities and no family history of abnormal hair. Trichoscopy showed the longitudinal groove in the hair shafts, characteristic of uncombable hair syndrome. Molecular genetic analysis revealed a new pathogenic variant (c.1374dup; p. Val459ArgfsTer15) in PADI3, not previously described.
-
Four‐month‐old with severe PIK3CA‐related overgrowth spectrum disorder successfully treated with alpelisb Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-03-06 María‐Laura Cossio, Josefina Rodríguez, Juan Carlos Flores, Florencia De Barbieri, Álvaro Flores, José Marín, Carla Florin, Francisco Cuevas, Monserrat Gutiérrez
PIK3CA‐related overgrowth spectrum (PROS) encompasses different clinical entities caused by somatic activating mutations in PIK3CA. Among PROS, CLOVES syndrome represents a severe phenotype with poor survival rate. We present the case of a 4‐month‐old girl with CLOVES syndrome successfully treated with alpelisib, a PIKC3A inhibitor.
-
Violaceous papules on the limbs of a 10‐year‐old girl Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-03-06 Lauren G. Yi, Anisha P. Valluri, Juanita Duran Rincon, Shyam Raghavan, Barrett J. Zlotoff
CASE PRESENTATION A 10-year-old Caucasian girl presented with a 1-year history of a pruritic, nontender, pustular rash on her legs and several weeks of oral ulcers. Medical history was notable for 6 months of abdominal pain and hematochezia. The rash started on her ankles and progressed to involve her torso, arms, and face. Physical examination revealed violaceous papules, some surmounted by pustules
-
Oral sirolimus for the treatment of juvenile xanthogranuloma: Report of two pediatric cases Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-03-06 Michelle Toker, Fatema Esaa Hassonjee, John Amodio, Morris C. Edelman, Kristina I. Emeghebo, Carolyn Fein Levy, Sheila Shaigany
Juvenile xanthogranuloma (JXG) with extensive cutaneous or visceral organ involvement is often associated with high morbidity and treatment commonly involves surgical excision, radiotherapy, systemic steroids, or chemotherapy. Sirolimus, a mammalian target of rapamycin (mTOR) inhibitor, is an oral antitumor and immunosuppressive therapy used to treat various neoplastic disorders, including histiocytic
-
Relationship between long‐acting reversible contraception and acne in a cohort of adolescents and young adults Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-03-06 Markus D. Boos, Morgan E. Ryan, Carly Milliren, Sarah Golub, Sofya Maslyanskaya, Michelle Escovedo, Amy DiVasta, Sarah Pitts
BackgroundThe use of progestin‐only long‐acting reversible contraception (LARC) may be a risk factor for acne. Few studies have focused primarily on the effects of hormonal LARC on the development or exacerbation of acne in adolescents and young adults. We sought to understand the incidence and management of acne following hormonal LARC insertion in this adolescent/young adult population.MethodsA secondary
-
Transient infantile lingual leukoplakia: An underrecognized cause of white tongues in infancy Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-02-27 Joseph M. Lam, Agnes Schwieger-Briel, Tram Nguyen, Antonio Torrelo
We have observed a distinct phenomenon of transient oral lingual leukoplakia in infancy and report 22 healthy infants with gray–white plaques on the dorsal tongue with sparing of the tip from four medical centers in three countries. The onset of the eruption ranged from 1 week to 7 months of life and resolved in 19 patients (86%, with 3 patients lost to follow-up). None of the eight patients examined
-
A review of hair removal modalities in pediatric patients: Ethical and clinical considerations Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-02-27 Eric Sanfilippo, Leslie Castelo-Soccio, Anna Yasmine Kirkorian
Unwanted hair is a common concern among patients presenting to pediatric dermatology clinics, and parents and patients alike inquire about the safety of methods employed for elective removal. Various methods of hair removal exist with different levels of invasiveness and permanence, from simple mechanical depilation to light-based therapies. All methods of hair removal appear to be safe and generally
-
Neutrophilic dermatosis in a patient with an IKZF1 variant and a review of monogenic autoinflammatory disorders presenting with neutrophilic dermatoses Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-02-27 Justina Guirguis, Sonia Iosim, Derek Jones, Maryel Likhite, Fei Chen, Chimene Kesserwan, Tatyana Gindin, Philip J. Kahn, David Beck, Vikash S. Oza, Kirsty Hillier
Monogenic diseases of immune dysregulation should be considered in the evaluation of children presenting with recurrent neutrophilic dermatoses in association with systemic signs of inflammation, autoimmune disease, hematologic abnormalities, and opportunistic or recurrent infections. We report the case of a 2-year-old boy presenting with a neutrophilic dermatosis, found to have a novel likely pathogenic
-
Unexpected location of a pilonidal sinus Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-02-27 Carme Grande-Moreillo, Sara Fuentes-Carretero, Francesca Corella-Vicente, Jaume Margarit-Mallol
Pilonidal sinus disease is typically located in the sacrococcygeal area, although it has been described in other locations. We present a rare case of pilonidal sinus on the scalp and its management.
-
Bier anemic spots, cyanosis, and urticaria-like eruption (BASCULE) syndrome in a 15-year-old male, responsive to high-dose fexofenadine Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-02-27 Elizabeth Keeling, Chantal Cotter, Sarah O'Mahony, Madonna Andrawis, Asad Salim
We describe an unusual presentation of Bier anemic spots, cyanosis, and urticaria-like eruption (BASCULE) syndrome in a 15-year-old male, recalcitrant to low-dose anti-histamines, which subsequently responded to high-dose fexofenadine.
-
Berdazimer gel for molluscum contagiosum in patients with atopic dermatitis Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-02-27 Amy S. Paller, Lawrence J. Green, Nanette Silverberg, Stephen Stripling, Martina Cartwright, Carolyn Enloe, Nick Wells, Elaine Kearney Kowalewski, Tomoko Maeda-Chubachi
Controlling molluscum contagiosum (MC) infections is critical in atopic dermatitis (AD) management. This post hoc analysis assessed the efficacy and safety of berdazimer gel, 10.3% (topical, antiviral, nitric oxide–releasing medication) versus vehicle in MC patients with or without AD.
-
No seroconversion in a retrospective study analyzing QuantiFERON TB-gold testing in pediatric psoriasis and hidradenitis suppurativa patients taking biologic therapy at an academic center in New York City Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-02-27 Apostolos Katsiaunis, Jade Conway, Shari R. Lipner
Guidelines are inconsistent regarding annual QuantiFERON® TB Gold (QFT) tests in children taking biologics for dermatological conditions, and there is limited research on seroconversion, especially in regions with high tuberculosis (TB) prevalence. A retrospective review of pediatric patients taking biologic treatment for psoriasis or hidradenitis suppurativa (HS) who had one baseline and at least
-
Idiopathic aseptic facial granuloma: A retrospective study of 43 cases Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-02-27 Lola Kuperman Wilder, Antonela Lamberti, Paula Boggio, María Eugenia Abad, Paula C. Luna, Margarita Larralde
Idiopathic aseptic facial granuloma (IAFG) is an underrecognized pediatric skin disease, currently considered within the spectrum of rosacea. It usually manifests as a solitary, reddish, asymptomatic nodule on the cheek that resolves spontaneously.
-
Unresectable infantile myofibroma discovered in utero Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-02-27 Shannon Gurley, Ben J. Friedman, Tor Shwayder
The authors present a case of a proliferative nodule located beneath an infant's lower lip that was initially discovered on prenatal ultrasound and fetal magnetic resonance imaging (MRI). Biopsy revealed a smooth muscle actin‐positive spindled cell proliferation with hemangiopericytoma‐like vessels consistent with infantile myofibromatosis (IM). Since the location prevented surgical management, the
-
Pediatric dermatofibromas: Truncal predominance in younger children Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-02-27 Brenna G. Kelly, Joel C. Joyce, Melodee A. Liegl, Amy Pan, Karolyn A. Wanat, Leah Lalor
Pediatric dermatofibromas are considered rare in young children and have not been well characterized, often misdiagnosed clinically. We performed a retrospective case series of children younger than 18 years with histopathologically diagnosed dermatofibromas at our institutions and evaluated age at onset and diagnosis, sex, lesion location, and size, associated symptoms, change over time, and pre‐biopsy
-
Pediatric hidradenitis suppurativa publication trends: 2012 to 2022 Pediatr. Dermatol. (IF 1.5) Pub Date : 2024-02-27 Sarah E. Park, Terri Shih, Caitlyn Dagenet, Marcia Hogeling, Meagan Hughes, Justin Gillenwater, Vivian Y. Shi, Jennifer L. Hsiao
There is a paucity of bibliometric data on pediatric‐focused hidradenitis suppurativa (HS) publications. To better characterize research trends in pediatric HS and gaps in literature, we systematically searched PubMed between 2012 and 2022 for publications on pediatric HS and collected data on study design, topic, country, and level of evidence. Of 109 articles that met inclusion criteria, less than