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The Novel MFG-E8-derived Oligopeptide, MOP3, Improves Outcomes in a Preclinical Murine Model of Neonatal Sepsis J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-19 Colleen P. Nofi, Jose M. Prince, Monowar Aziz, Ping Wang
Neonatal sepsis is a devastating inflammatory condition that remains a leading cause of morbidity and mortality. Milk fat globule-EGF-factor VIII (MFG-E8) is a glycoprotein that reduces inflammation, whereas extracellular cold-inducible RNA binding protein (eCIRP) worsens inflammation. This study aimed to determine the therapeutic potential of a novel MFG-E8-derived oligopeptide 3 (MOP3) designed to
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Does Delayed Diagnosis of Hirschsprung Disease Impact Post-operative and Functional Outcomes? A Multi-Center Review From the Pediatric Colorectal and Pelvic Learning Consortium J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-18 Sarah Ullrich MD MHS, Kelly Austin MD, Jeffrey R. Avansino MD, Andrea Badillo MD, Casey M. Calkins MD, Rachel C. Crady MS, Megan M. Durham MD, Megan K. Fuller MD, Ankur Rana MD, Ron W. Reeder PhD, Rebecca M. Rentea MD, Michael D. Rollins MD, Payam Saadai MD, K. Elizabeth Speck MD, Richard J. Wood MD, Kathleen van Leeuwen MD, Jason S. Frischer MD, the Pediatric Colorectal and Pelvic Learning Consortium
Hirschsprung Disease (HD) is a rare cause of functional bowel obstruction in children. Patients are typically diagnosed in the neonatal period and undergo pull-through (PT) soon after diagnosis. The optimal management and post-operative outcomes of children who present in a delayed fashion are unknown. A multi-center retrospective review of children with HD was performed at participating Pediatric
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Assessing the Impact of Neighborhood and Built Environment on Pediatric Perioperative Care: A Systematic Review of the Literature J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-18 Miranda A. Chacon MD, Caitlin A. Cook MS MD, Katherine Flynn-O’Brien MD FACS FAAP, Jessica A. Zagory MD FACS FAAP, Pamela M. Choi MD FACS FAAP, Nicole A. Wilson PhD MD FACS FAAP
Neighborhood and built environment encompass one key area of the Social Determinants of Health (SDOH) and is frequently assessed using area-level indices. We sought to systematically review the pediatric surgery literature for use of commonly applied area-level indices and to compare their utility for prediction of outcomes. A literature search was conducted using PubMed, Ovid MEDLINE, Ovid MEDLINE
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Prevention of Parenteral Nutrition-Associated Cholestasis Using Reduced Dose Soybean Lipid Emulsion: A Multicenter Randomized Trial J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-17 Kathryn M. Maselli MD, Irene C. Carter BS, Niki Matusko MS, Seth Warchausky PhD, Allison B. Blackmer PharmD, Saleem Islam MD, Michael D. Rollins MD, Patrick J. Javid MD, Meghan A. Arnold MD
Reducing soybean lipid emulsion (SLE) dose may prevent parenteral nutrition-associated cholestasis (PNAC) but effects on growth and neurodevelopment are unknown. The purpose of this study was to evaluate the effect of reduced dose SLE on growth and neurodevelopment. Surgical neonates at 4 centers were randomized to standard SLE (3 g/kg/day) or reduced SLE (1 g/kg/day) over a 12-week period. Bilirubin
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Current Realities of Wilms Tumor Burden and Therapy in Ghana J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-16 Nelly-Ange T. Kontchou MD MBA, Emmanuel Amankwah MA, Issah Seidu MPhil MA, Laura L. Stafman MD PhD, Shilin Zhao PhD, Afua O.D. Abrahams MBChB FWACP FGCP, William Appeadu-Mensah MBChB FWACS FGCS, Harold N. Lovvorn III MD FACS FAAP, Lorna A. Renner MBChB MPH FRCPCH FGCPS
Between 2005-2014, Ghana’s Wilms tumor (WT) 2-year disease-free survival of 44% trailed behind high-income countries. This study aimed to uncover social determinants of health leading to preventable WT death in Ghana. WT patient records (2014-2022) at Korle-Bu Teaching Hospital (KBTH; Ghana) were reviewed retrospectively. Demographics, clinical course, tumor characteristics, and survival were evaluated
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Opioid Prescriptions at Discharge After Minimally Invasive Repair of Pectus Excavatum are Reduced with Cryoablation J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-16 R. Scott Eldredge MD, Brielle Ochoa MD, Jared Carmichael, Daniel Ostlie MD, Justin Lee MD, Lisa McMahon MD, David Notrica MD, Benjamin E. Padilla MD
The minimally invasive repair of pectus excavatum (MIRPE) is associated with significant postoperative pain and opioid use. The objective of this study was to determine the effect of intercostal nerve cryoablation (Cryo) on inpatient and post-hospital opioid prescription practices following MIPRE. A retrospective review at a single pediatric center was conducted of patients ≤21 years old who underwent
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Bridging the Knowledge Gap: A Toolkit on Reproductive Rights for Pediatric Surgeons in the Post-Dobbs Era J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-16 Sindhu V. Mannava MD, Amanpreet Brar MD, Utsav Patwardhan MD, Jodi Godfrey RDN MS, Elizabeth Berdan MD MS FAPSA FAAP, Kenneth Gow MD MHA FACS FAAP, J. Leslie Knod MD FACS FAAP
The ripple effect of the Supreme Court ruling in has impacted physicians and patients across numerous medical specialties. In pediatric surgery, the patient population ranges from fetus to the pregnant patient. There is a gap in the knowledge of pediatric surgeons regarding abortion laws and access. This project aims to bridge the gap by creating access to reliable resources which may be used to optimize
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The Shared Ovary: A Multidisciplinary Discussion with Pediatric and Adolescent Gynecology J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-16 Barrie S. Rich, Kate McCracken, Christa Nagel, Lisa Allen, Jennifer H. Aldrink
Pediatric and adolescent ovarian lesions are common and are frequently managed by both pediatric surgeons and pediatric and adolescent gynecologists. During the 2023 American Academy of Pediatric Section on Surgery meeting, an educational symposium was delivered focusing on various aspects of management of pediatric and adolescent benign and malignant masses, borderline lesions, and fertility options
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Updates from the Other Side of the Drape: Recent Advances in Multimodal Pain Management and Opioid Reduction Among Pediatric Surgical Patients J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-16 Andrew D. Franklin, KuoJen Tsao, Rabab Barq, Lorraine I. Kelley-Quon, Giorgio Veneziano, Jennifer H. Aldrink
As the management of acute pain for children undergoing surgical procedures as well as recognition of the short and long term risks of exposure to opioids has evolved, multimodal and multidisciplinary approaches using organized pathways has resulted in improved perioperative outcomes and patient satisfaction. In this 2023 symposium held at the American Academy of Pediatrics on Surgery meeting, a multidisciplinary
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Day to Day Advocacy by Pediatric Health Care Providers J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-16 Peter T. Masiakos, Kris R. Jatana, Mark DelMonte, Ala Stanford, Jennifer H. Aldrink
This manuscript highlights the impressive advocacy work that members of the American Academy of Pediatrics have achieved and serves to inspire pediatric health care providers of all specialties to pursue such efforts beyond the acute physical need of the child. This article represents one of the Symposia presented at the 2023 American Academy of Pediatrics Section on Surgery.
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Antenatally Detected Choledochal Malformation: What are we waiting for? J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-16 Sherif Abdelmaksoud MD FRCS (Paeds), Rania Kronfli MSc FRCS (Paeds), Erica Makin MSc FRCS (Paeds), Mark Davenport ChM FRCS (Paeds)
An increasing proportion of congenital choledochal malformation (CCM) are being detected on antenatal ultrasound. However, the actual timing of its surgical correction remains controversial with some series showing an excess of complications the earlier the operation. The aim of this study was to characterize the pathophysiological aspects of this cohort from the perspective of age at surgery in order
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Thoracic musculoskeletal deformities following surgical treatment of esophageal atresia - thoracoscopic versus open approach: A retrospective two centers cohort study J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-16 Dominika Borselle MD, Konrad Grochowski MD, Sylwester Gerus MD, Krzysztof Międzybrodzki MD PhD, Krzysztof Kołtowski MD, Aleksandra Jasińska MD PhD, Andrzej Kamiński MD PhD, Dariusz Patkowski MD PhD
Thoracic musculoskeletal deformities are significant complications following open correction of esophageal atresia (EA) during long-term follow-up. We aimed to compare the frequency and severity of thoracic musculoskeletal deformities after open and thoracoscopic repair of EA. We hypothesized that fewer deformities would occur following the less invasive thoracoscopic approach. This retrospective study
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Validation of the Clavien-Madadi classification for unexpected events in pediatric surgery: A collaborative ERNICA project J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-16 Omid Madadi-Sanjani, Joachim F. Kuebler, Julia Brendel, Sara Costanzo, Anna L. Granstroem, Emrah Aydin, Stavros Loukogeorgakis, Martin Lacher, Soeren Wiesner, Anja Domenghino, Pierre-Alain Clavien, Annika Mutane, Simon Eaton, Benno M. Ure
The Clavien-Madadi classification is a novel instrument for the assessment and grading of unexpected events in pediatric surgery, based on the Clavien-Dindo classification. The system has been adjusted to better fit the pediatric population in a prospective single-center study. There is a need now to validate the Clavien-Madadi classification within an international expert network. A pediatric surgical
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Opportunity for Reduction of Intensive Care Unit Resource Utilization in Pediatric Blunt Liver and Spleen Injuries: A National Trauma Data Bank Analysis J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-16 Theodore Wang, Paul Truche, Rachel Sachs, Arunachalam Thenappan, Yi-Horng Lee, Sathyaprasad C. Burjonrappa
Guidelines for blunt liver and spleen injury (BLSI) by the Arizona-Texas-Oklahoma-Memphis-Arkansas Consortium (ATOMAC) emphasize hemodynamic stability over injury grade when considering non-operative management (NOM). In this study, we examined rates of intensive care unit (ICU) admission for children with isolated low-risk BLSI among US hospitals. The National Trauma Data Bank (NTDB) was queried for
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Comparing healthcare needs in extremely low birth weight infants with NEC and spontaneous intestinal perforation J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-16 Priyanka V. Chugh MD MS, Emily Nes MD, Katherine Culbreath MD, Gregory Keefe MD, Erika M. Edwards PhD MPH, Kate A. Morrow MS, Danielle Ehret MD MPH, Roger F. Soll MD, Biren P. Modi MD MPH, Jeffrey D. Horbar MD, Tom Jaksic MD PhD
Necrotizing enterocolitis (NEC) and spontaneous intestinal perforation (SIP) affect 6-8% of extremely low birth weight (ELBW) infants. SIP has lower mortality than NEC, but with similar short-term morbidity in length of stay, growth failure, and supplemental oxygen requirements. Comparative long-term neurodevelopmental outcomes have not been clarified. Data were prospectively collected from 59 North
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Letter to the Editor in Response to: Complete Resection of Necrotic Bowel Improves Survival in NEC J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-16 Cem Kaya, Ramazan Karabulut, Zafer Turkyilmaz, Kaan Sonmez
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Discrepancies Between Imaging Reports and Operative Findings in Patients with Cloaca: A Call For Expansion of the Mullerian Anomalies Classification J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-15 Brielle Ochoa, Erica M. Weidler, Kathleen van Leeuwen
There is wide variation in the language used to describe Mullerian structures. To standardize terminology, the American Society of Reproductive Medicine (ASRM) created the Mullerian Anomalies Classification (MAC) in 2021. The objective of this study was to evaluate the applicability of the MAC nomenclature to pediatric patients with cloaca. A retrospective review of all patients with cloaca was performed
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Sex-based Disparities in the Management of Pediatric Gonadal Torsion J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-15 William G. Lee MD, Shadassa Ourshalimian MPH, Olivia A. Keane MD, Makayla O’Guinn MD, Marjorie N. Odegard MD, Stephen S. Sparks MD, Lorraine I. Kelley-Quon MD MSHS FACS FAAP
In 2015, the U.S. News and World Report (USNWR) implemented a quality metric to expedite surgery for testicular (TT), but not ovarian torsion (OT). This study examined OR timing among children with suspected TT and OT before and after this metric. A single-center retrospective cohort study of children (1-18yr) who underwent surgery for suspected gonadal torsion was performed. Time to OR (TTOR) from
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PIM Kinase inhibition sensitizes neuroblastoma to doxorubicin J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-15 Janet R. Julson M.D., Colin H. Quinn Ph.D., Nazia Nazam Ph.D., Laura V. Bownes M.D., Jerry E. Stewart B.S., Elizabeth A. Beierle M.D. FAAP
Chemoresistance contributes to relapse in high-risk neuroblastoma. Cancer cells acquire resistance through multiple mechanisms, including drug efflux pumps. In neuroblastoma, multidrug resistance-associated protein-1 (MRP1/ efflux pump expression correlates with worse outcomes. These pumps are regulated by PIM kinases, a family of serine-threonine kinases, overexpressed in neuroblastoma. We hypothesized
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Comparative Effects on Fetal Hematopoiesis and Placental Inflammation from Mesenchymal and Hematopoietic Stem Cells as Agents of Transamniotic Stem Cell Therapy (TRASCET) in a Syngeneic Model of Intrauterine Growth Restriction J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-15 Kamila Moskowitzova MD, Abbie E. Naus MD, Ina Kycia PhD, Tanya T. Dang, Yash Shroff, Emilia Bletsas, Kaitlin Mullin, David Zurakowski PhD, Dario O. Fauza MD PhD FAAP
We compared transamniotic stem cell therapy (TRASCET) using either mesenchymal (MSCs) or hematopoietic (HSCs) stem cells on fetal hematopoiesis in a syngeneic model of intrauterine growth restriction (IUGR). Lewis dams exposed to cycling hypoxia (10.5% O) in late gestation had their fetuses (n=83) either receiving no intervention (untreated; n=9), or intra-amniotic injections of either HSCs (HSC; n=34)
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How far We Go for Surgery: Distance to Pediatric Surgical Care in Indiana J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-15 Cassandra Anderson BS BA, Ben Duggan BS, Cameron Colgate MS, Manisha Bhatia MD MS MPH, Brian Gray MD
Despite increasing numbers of pediatric surgery training programs, access to pediatric surgical care remains limited in non-academic and rural settings. We aimed to characterize demographic and patient factors associated with increased distance to selected pediatric surgical procedures in Indiana. This IRB-approved retrospective review analyzed pediatric patients undergoing appendectomy, cholecystectomy
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The risk of adhesive Bowel obstruction in children with appendicitis: A systematic review J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-14 Neel Doshi, Soham Bandyopadhyay, Madeline Green, Edward Richardson, Ahmad Komber, Si Emma Chen, Rahul Shah, Kokila Lakhoo
Complicated appendicitis is associated with a higher risk of postoperative complications, including adhesive bowel obstruction. The aim of this meta-analysis is to investigate the difference in rates of postoperative bowel obstruction in paediatric patients with complicated versus simple appendicitis and whether this is influenced by the surgical approach. A systematic literature search following PRISMA
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Cold Therapy for Pain Control in Pediatric Appendectomy Patients: A Randomized Controlled Trial J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-14 P. Nina Scalise, Donna C. Koo, Jonathan M. Durgin, Brianna Slatnick Truche, Steven J. Staffa, Christine Greco, Jean Solodiuk, Eliza J. Lee, Farokh R. Demehri, Heung Bae Kim
Topical ice has been shown to reduce pain scores and opioid use in adults with midline abdominal incisions. This study was designed to evaluate the efficacy of a cold therapy system in children following laparoscopic appendectomy. Patients 7 years and older who underwent laparoscopic appendectomy at our institution from December 2021-September 2022 were eligible. Patients were randomized to standard
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Rates of Hirschsprung-Associated Enterocolitis Decrease with Increasing Child Opportunity Index J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-14 Shruthi Srinivas MD, Katelyn Henderson BS, Kristine L. Griffin MD, Elizabeth Thomas MS, Richard J. Wood MD, Jacob C. Langer MD FAAP, Ihab Halaweish MD
Hirschsprung-associated enterocolitis (HAEC) is the most common cause of morbidity and mortality in patients with Hirschsprung disease (HD). There is a correlation between social determinants of health (SDOH) and outcomes in children with HD. The Child Opportunity Index (COI) is a publicly available dataset that stratifies patients by address into levels of opportunity. We aimed to understand if a
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THE IMPACT OF ANTIBIOTIC STRATEGY ON OUTCOMES IN SURGICALLY MANAGED NECROTIZING ENTEROCOLITIS J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-14 Madeline Goldfarb BA, Gerald Gollin MD FAAP
We sought to evaluate postoperative antibiotic practices in a large population of patients with necrotizing enterocolitis (NEC) and determine whether any regimens were associated with better outcomes. The Pediatric Health Information Systems (PHIS) database was queried to identify patients who underwent an intestinal resection for acute NEC between July, 2016 and June, 2021. Data regarding post-resection
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Evaluation of Post-Neonatal Intensive Care Unit Home Irrigations Prior to Pull-Through: Implications for Hirschsprung Disease Management J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-14 Elizaveta Bokova, Ninad Prasade, Wendy E. Lewis, Christine N. Feira, Irene Isabel P. Lim, Tolulope A. Oyetunji, Rebecca M. Rentea
Pull-through procedures for Hirschsprung disease (HD) can be performed during the Neonatal Intensive Care Unit (NICU) stay or delayed until discharge following home irrigations. This study assesses the safety of a delayed pull-through as an alternative to neonatal reconstruction in infants with successful abdomen decompression with home irrigations based on Hirschsprung-associated enterocolitis (HAEC)
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Invited Review Journal of Pediatric Surgery Primary Liver Transplant in Biliary Atresia: The Case for and Against J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-14 Mark Davenport ChM FRCS (Eng) FRCS (Paeds), Riccardo Superina MD FRCS (C) FACS
The role of liver transplantation as a primary procedure in biliary atresia has been argued over for at least 40 years, indeed since the coming of age of safe liver transplantation during the 1980s. Yet, it is not a common option in most series (usually ≤5%) and typically reserved for those with late presentations (arguably >100 days) with established cirrhosis.
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Reply to Letter to the Editor by Lohmann and Fernandes J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-08 Kazunori Masahata, Kouji Nagata, Keita Terui, Takuya Kondo, Ashley H. Ebanks, Matthew T. Harting, Terry L. Buchmiller, Yasunori Sato, Hiroomi Okuyama, Noriaki Usui, for the Congenital Diaphragmatic Hernia Study Group
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Reply to the Letter to the Editor by Xu G J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-05 Hyung Joo Park, Gongmin Rim, Seung Keun Yoon
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Use of Vacuum-Assisted Closure to Reduce the Likelihood of Wound Complications After Limb-Sparing Resection of Pediatric Primary Bone Sarcomas of the Femur J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-05 Chance Cuthbert, Tarek Zaghloul, Shalini Bhatia, Suraj Sarvode Mothi, Erma Davis, Heather G. Heavens, Michael W. Bishop, Lindsay J. Talbot, Michael D. Neel, Abdelhafeez H. Abdelhafeez
Limb-sparing surgery is the standard of care for primary bone tumors. However, such procedures are associated with high rates of wound complications, specifically in lower-extremity surgeries. Therefore, identifying and implementing interventions to minimize the likelihood of wound complications after limb-sparing resection of the lower extremity is crucial. Patients who underwent limb-sparing osteosarcoma
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Mesenchymal Stem Cells Attenuates Hirschsprung diseases - Associated Enterocolitis by Reducing M1 Macrophages Infiltration via COX-2 Dependent Mechanism J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-04 Xinyao Meng, Jun Xiao, Jing Wang, Minxian Sun, Xuyong Chen, Luyao Wu, Ke Chen, Zejian Li, ChenZhao Feng, Didi Zhuansun, Jixin Yang, Xiaojuan Wu, Donghai Yu, Wei Li, Yonghua Niu, Ying He, Mingfa Wei, Feng Chen, Bo Xiong, Jiexiong Feng, Tianqi Zhu
Hirschsprung disease-associated enterocolitis (HAEC) is a common life-threatening complication of Hirschsprung disease (HSCR). We aimed to investigate the effectiveness, long-term safety and the underlying mechanisms of Mesenchymal stem cells (MSCs) based therapy for HAEC. Specimens from HSCR and HAEC patients were used to assess the inflammatory condition. Ednrb knock-out mice was used as HAEC model
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Using Outcome-Based Vital Sign Ranges can Enhance the Identification of Major Trauma in Children J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-02 Sriram Ramgopal
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Female Fertility Cryopreservation Outcomes in Childhood Cancer: A Systematic Review J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-03-01 Srinithya R. Gillipelli, Luca Pio, Paul D. Losty, Abdelhafeez H. Abdelhafeez
As survival rates in childhood cancer progress significantly, health outcomes in adulthood are pivotal to quality of life (QoL). Female patients undergoing chemotherapy and radiation for childhood cancer may experience adverse effects such as gonadotoxicity-related ovarian insufficiency. Ovarian tissue cryopreservation (OTC) is well studied in adults, but has only recently started to be explored in
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Letter to the Editor in Response to: Predictors of Mortality in Very Low Birth Weight Neonates With Congenital Diaphragmatic Hernia J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-02-29 Pablo Lohmann, Joseph Garcia-Prats
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Impact of Surgical Timing (Primary, Delayed, or Second Look) on Surgical Morbidity and Outcomes in Malignant Germ Cell Tumor of the Ovary in Children J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-02-29 Sajid S. Qureshi, Saiesh Reddy Voppuru, Vasundhara Smriti, Akshay Baheti, Sanket Shah, Girish Chinnaswamy, Maya Prasad, Badira C. Parambil, Venkata RM. Gollamudi, Poonam Panjwani, Mukta Ramadwar, Nayana Amin, Seema A. Kembhavi
Malignant ovarian germ cell tumors (MOGCT) are rare in children. Surgery with or without chemotherapy is the primary treatment approach. This study aimed to analyze the impact of primary and delayed surgery on surgical morbidity and outcomes. Second-look surgery after inadequate surgical staging and the various components of surgical staging were also evaluated. Children below 15 years with MOGCT treated
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One-year Results of Minimally Invasive Sutured Fixation of the Slipped Ribs in the Pediatric Population J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-02-29 Andreas Polycarpou, Trevor C. Chopko, Amy E. Glasgow, Sarah R. McCarthy, Daniel R. Hilliker, Robert T. Wilder, Denise B. Klinkner
Costal cartilage resection with or without rib resection is the gold standard surgery for slipping rib syndrome. Minimally invasive restoration of normal anatomy via nonabsorbable sutures has been described in the adult population with encouraging results. We sought to assess the efficacy of minimally invasive sutured fixation of the hypermobile rib in the pediatric population. A retrospective review
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Management of Pediatric Patients With Spontaneous Pneumomediastinum: A Retrospective Chart Review J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-02-29 Vivek Patel, Nathalie Carey, Daniel Briatico, Lisa VanHouwelingen
Given the paucity of data on pediatric spontaneous pneumomediastinum (SPM), management is largely informed by extrapolation from adult studies or personal clinical experience, resulting in significant heterogeneity. The purpose of this study was to describe how pediatric patients with SPM are clinically managed at our institution and propose a treatment algorithm. Retrospective chart review of pediatric
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Letter to the Editor in Response to: Predictors of Mortality in Very Low Birth Weight Neonates with Congenital Diaphragmatic Hernia J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-02-28 Sharada H. Gowda, Caraciolo Fernandes
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Antenatal Administration of Extracellular Vesicles Derived From Amniotic Fluid Stem Cells Improves Lung Function in Neonatal Rats With Congenital Diaphragmatic Hernia J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-02-28 Rebeca L. Figueira, Naghmeh Khoshgoo, Fabian Doktor, Kasra Khalaj, Tasneem Islam, Nazgol Moheimani, Matisse Blundell, Lina Antounians, Martin Post, Augusto Zani
The severity of pulmonary hypoplasia is a main determinant of outcome for babies with congenital diaphragmatic hernia (CDH). Antenatal administration of extracellular vesicles derived from amniotic fluid stem cells (AFSC-EVs) has been shown to rescue morphological features of lung development in the rat nitrofen model of CDH. Herein, we evaluated whether AFSC-EV administration to fetal rats with CDH
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Correlation of CT Scan Response to Necrosis and Volume Changes With Histopathology in Children With Wilms' Tumor J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-02-27 Niaz Nilave, Sajida Nahid, Saiyeda Karim, Shahnoor Islam, Amirul Morshed
Wilms’ tumor is the most common renal tumor in children. To correlate the percentage of necrosis and tumor volume change found in preoperative Contrast Enhance Computed Tomography (CECT) scan of the abdomen with post-operative histopathological findings of Wilms Tumor (WT). In this prospective study from January 2020 to December 2022, out of 33 patients, 15 patients with unilateral localized WT (stage
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Should Pediatric Surgical Oncologists Receive Training in Vascular Surgery ? A Practice Survey Report From the International Society of Paediatric Surgical Oncology (IPSO) J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-02-26 Prince Raj, Paul D. Losty, Martin T. Corbally
Is vascular training in paediatric surgical oncology considered desirable ? A voluntary survey of work practice was undertaken with the surgeon membership of The International Society Of Paediatric Surgical Oncology (IPSO) using a structured designed questionnaire. A total of 149 IPSO surgeon members completed the survey. 57% (N = 84) of surgeons surveyed had no specific training in vascular surgery
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Proliferative Effects of Mesenchymal Stromal Cells on Neuroblastoma Cell Lines: Are They Tumor Promoting or Tumor Inhibiting? J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-02-26 Kathleen Doyle, Maria Sutter, Monica Rodriguez, Abd-Elrahman Hassan, Priyadarsini Kumar, Erin Brown
Neuroblastoma is a common pediatric malignancy with poor survival for high-risk disease. Mesenchymal stromal cells (MSCs) have innate tumor-homing properties, enabling them to serve as a cellular delivery vehicle, but MSCs have demonstrated variable effects on tumor growth. We compared how placental MSCs (PMSCs) and bone marrow-derived MSCs (BM-MSCs) affect proliferation of neuroblastoma (NB) cells
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Incidence and Risk Factors for Chyle Leaks After Neuroblastic Tumor Resection: A Systematic Review of Published Studies J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-02-26 Arimatias Raitio, Paul D. Losty
Chyle leakage/ascites after surgical resection of neuroblastic tumors may delay the start of chemotherapy and worsen prognosis. Previous studies have reported a highly variable incidence and risk factors remain largely unknown. This study aims to analyze the true incidence of chyle leaks and ascites and seeks to identify risk factors and optimal treatment strategies. Medline/Embase databases were searched
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Robotic-assisted Pediatric Thoracic and Abdominal Tumor Resection: An Initial Multi-center Review J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-02-26 Wendy Jo Svetanoff, Michela Carter, Karen A. Diefenbach, Marc Michalsky, Daniel DaJusta, Edward Gong, Timothy B. Lautz, Jennifer H. Aldrink
Robotic-assisted minimally invasive surgery (RA-MIS) for tumor resection is an emerging technology in the pediatric population with significant promise but unproven safety and feasibility. A multi-center retrospective review of patients ≤18 years undergoing RA-MIS tumor resection from December 2015–March 2023 was performed. Patient demographics, perioperative variables, and complication rates were
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Factors Associated With Long-term Survival in Children With Bronchial and Lung Carcinoid Tumors J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-02-24 Swathi R. Raikot, Courtney N. Day, R. Paul Boesch, Wendy Allen-Rhoades, Stephanie F. Polites
Bronchial carcinoids are rare in children and the treatment is based on tumor behavior in adults. The purpose of this study was to determine factors and management strategies associated with long-term survival in the pediatric population using a national cohort. Patients aged ≤20 years with bronchial carcinoid tumors were identified in the 2004–2020 National Cancer Database using ICD-O-3 codes. Tumor
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Clinical Application and Further Development of Augmented Reality Guidance for the Surgical Localization of Pediatric Chest Wall Tumors J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-02-24 Rémi van der Woude, Matthijs Fitski, Jasper M. van der Zee, Cornelis P. van de Ven, Guus M.J. Bökkerink, Marc H.W.A. Wijnen, Jene W. Meulstee, Tristan P.C. van Doormaal, Françoise J. Siepel, Alida F.W. van der Steeg
Surgical treatment of pediatric chest wall tumors requires accurate surgical planning and tumor localization to achieve radical resections while sparing as much healthy tissue as possible. Augmented Reality (AR) could facilitate surgical decision making by improving anatomical understanding and intraoperative tumor localization. From January 2021, we used the HoloLens 2 for pre-incisional tumor localization
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Multi-modal 3-Dimensional Visualization of Pediatric Neuroblastoma: Aiding Surgical Planning Beyond Anatomical Information J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-02-24 Dominique C. Simons, Myrthe A.D. Buser, Matthijs Fitski, Cornelis P. van de Ven, Bernhard ten Haken, Marc H.W.A. Wijnen, Can Ozan Tan, Alida F.W. van der Steeg
Patient-specific 3D models of neuroblastoma and relevant anatomy are useful tools for surgical planning. However, these models do not represent the heterogenous biology of neuroblastoma. This heterogeneity is visualized with the ADC and I-MIGB-SPECT-CT imaging. Combining these multi-modal data into preoperative 3D heatmaps, may allow differentiation of the areas of vital and non-vital tumor tissue
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Ovarian Tissue Collection for Fertility Preservation in Children: The Need for Standardised Surgical Practice Guidance J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-02-24 Sarah Braungart, Sheila Lane, Christian M. Becker, Nicholas Alexander
Chemotherapy, pelvic radiotherapy (including total body irradiation) and novel compounds used to treat children and teenagers with benign or malignant diseases can lead to impaired fertility. For prepubertal female patients at high risk of treatment-related infertility, upfront storage of ovarian tissue is increasingly being recognised as standard of care. No surgical guidelines exist to ensure best
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Systematic Lymphatic Repair for Reduction of Postoperative Lymphatic Leak Following Neuroblastoma Resection J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-02-24 Gideon Purwono, York Tien Lee, Joyce HY. Chua, Amos HP. Loh
Gross total resection of neuroblastoma is associated with lymphatic leaks that can delay postoperative resumption of treatment. To prevent postoperative lymphatic leak, we introduced systematic lymphatic repair (SLR), which involved oversewing the entire edge of the disrupted lymphatic plane after neuroblastoma resection. We sought to study the impact of SLR on postoperative lymphatic leak and time
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The Use of a High Flow PICC Catheter for Stem Cell and Lymphocyte Apheresis: The Initial Experience of a Pediatric Oncology Center in Brazil J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-02-24 Vilani Kremer, Andréia Rheinheimer, Ana Luiza Rodrigues, Andressa Taborda, Robson Coelho, Antonella Zanette
Autologous hematopoietic stem cell transplant (HSCT), characterized by high intensity chemotherapy followed by the infusion of HSC previously collected from the peripheral blood, is a procedure used in the treatment of several malignancies. In pediatrics, the apheresis procedure represents a challenge, due to the need for insertion of a rigid central venous catheter (CVC) in small children. The CVC
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International Society of Paediatric Surgical Oncology (IPSO): A Short History, Developments, and Current Status J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-02-24 Paul D. Losty, Pablo Lobos, Chan Hon Chui, Andrew M. Davidoff
The International Society of Paediatric Surgical Oncology (IPSO) was officially inaugurated in 1991 through the creativeness and inspiration of a collective dynamic group of paediatric surgeons committed to advancing childhood cancer. This article traces the origins and birth of IPSO tracking its modern day development to a growing world community of paediatric surgeon oncology members. 5
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Transition From Pediatric to Adult Healthcare for Colorectal Conditions: A Systematic Review J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-02-23 Emma J. Moore, Susan M. Sawyer, Sebastian K. King, Melissa Y. Tien, Misel Trajanovska
Despite surgical advances for complex congenital colorectal conditions, such as anorectal malformation (ARM) and Hirschsprung disease (HD), many adolescents require transfer from specialist pediatric to adult providers for ongoing care. A systematic review of PubMed, MEDLINE and Embase was conducted to identify what is known about the transitional care of patients with ARM and HD (PROSPERO # CRD42022281558)
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Functional and Health-Related Quality of Life Outcomes into Adulthood for Females Surgically Treated for Anorectal Malformation J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-02-20 Joshua Gertler, Anna Löf Granström, Jenny Oddsberg, Anna Gunnarsdóttir, Anna Svenningsson, Tomas Wester, Lisa Örtqvist
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Living Donor Whole and Partial Liver Grafts, Deceased Donor Whole Liver and SPLIT: Outcome Comparison J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-02-19 João Seda Neto, Carolina M. Costa, Renata Pugliese, Rodrigo Vincenzi, Marcel R. Benavides, Nathália P.R. Travassos, Caio M.V. de Oliveira, Karina Roda, Debora P. Fernandes, Mário Kondo, Eduardo A. Fonseca
Currently, graft options for pediatric liver transplantation (PLT) include whole (WL) and partial (P) grafts, in the form of either deceased donor transplantation (DD) or living donor liver transplantation (LD). WL transplants from LD are commonly referred to as domino LT. The objective of this manuscript is to compare the outcomes of PLT performed with each of the available graft options. Retrospective
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Chest Wall Dermatitis Patterns Following Thoracoscopic Intercostal Nerve Cryoablation for Surgical Correction of Pectus Excavatum J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-02-16 J. Benjamin Pitt, Michela Carter, Suhail Zeineddin, Laurie Sands, Suzanne Kujawa, Amparo Perez, Walter J. Liszewski, Fizan Abdullah, Seth D. Goldstein
Intercostal nerve cryoablation (INC) has been shown to reduce postoperative pain and length of stay following surgical correction of pectus excavatum (SCOPE). Some patients have developed chest wall dermatological symptoms after INC that can be mistaken for metal allergy or infection. The purpose of this study is to report the symptoms, severity, incidence, and treatment of post-cryoablation dermatitis
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An Electronic Health Record-integrated Web Application Augments a QI-Directed Morbidity & Mortality Conference and Improves Quality of Care J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-02-16 Nitin Sajankila, Thomas Javens, Josh Hampl, Courtney Coleman, Jami Murnane, Brian D. Kenney, Gail E. Besner
In 2014, we developed a QI-directed Morbidity and Mortality (M&M) Conference, prioritizing discussion of individual and system failures, as well as development of action items to prevent failure recurrence. However, due to a reliance on individual electronic documents to store M&M data, our ability to assess trends in failures and action item implementation was hindered. To address this issue, in 2019
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Microinjection with nanoparticles to deliver drugs in prenatal lung explants - a pilot study for prenatal therapy in congenital diaphragmatic hernia J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-02-14 Yuichiro Miyake, Wai Hei Tse, Jia Qi Wang, Daywin Patel, Arzu Ozturk, Atsuyuki Yamataka, Richard Keijzer
Fetoscopic endoluminal tracheal occlusion (FETO) improves the survival rate in fetuses with severe congenital diaphragmatic hernia (CDH). We hypothesize that prenatal therapies into the trachea during FETO can further improve outcomes. Here, we present an microinjection technique with rat lung explants to study prenatal therapy with nanoparticles. We used microsurgery to isolate lungs from rats on
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Modifiable preoperative risk factors to mitigate postoperative site infection following pediatric gastrostomy J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-02-13 Shelby R. Sferra, Sara Donnelly, Sandra Kabagambe, Erica M. Fallon
There are limited studies assessing modifiable preoperative risk factors for pediatric laparoscopic gastrostomy tubes (LGT) and percutaneous endoscopic gastrostomy (PEG) tubes. We sought to evaluate the effect of demographics and surgical/infectious history on the superficial infection rate following gastrostomy tube (GT) placement. After IRB approval, we conducted a single-institution retrospective
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The State of Artificial Intelligence in Pediatric Surgery: A Systematic Review J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-02-13 Mohamed Elahmedi, Riya Sawhney, Elena Guadagno, Fabio Botelho, Dan Poenaru
Artificial intelligence (AI) has been recently shown to improve clinical workflows and outcomes - yet its potential in pediatric surgery remains largely unexplored. This systematic review details the use of AI in pediatric surgery. Nine medical databases were searched from inception until January 2023, identifying articles focused on AI in pediatric surgery. Two authors reviewed full texts of eligible
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Letter to the Editor in Response to: Risk Factors for Preoperative Pneumothorax in Neonates with Isolated Left-Sided Congenital Diaphragmatic Hernia: An International Cohort Study J. Pediatr. Surg. (IF 2.4) Pub Date : 2024-02-12 Pablo Lohmann, Caraciolo J. Fernandes