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Fetoscopic laser coagulation for twin-to-twin transfusion syndrome: a comparison of flexible 1.0/1.2 mm fetoscopes with curved sheaths of 2.7/3.3 mm2 vs. 2 mm fetoscopic lens technique with sheaths of 6.6/11.3 mm2 J. Perinat. Med. (IF 2.4) Pub Date : 2024-03-27 Michael Tchirikov, Anja Zühlke, Natalia Schlabritz-Lutsevich, Michael Entezami, Gregor Seliger, Michael Bergner, Weijing Li, Angela Köninger, Andreas Wienke, Rustem Yusupbaev, Andreas D. Ebert
Objectives Fetoscopic laser coagulation of placental anastomoses is usually performed for a treatment of twin-to-twin transfusion syndrome (TTTS). A common complication of fetoscopic laser coagulation for TTTS is preterm preliminary rupture of fetal membranes (PPROM) aggravating the neonatal outcome significantly. However, use of an flexible 1 mm fetoscope with an curved sheath could reduce iatrogenic
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Impact of birth weight to placental weight ratio and other perinatal risk factors on left ventricular dimensions in newborns: a prospective cohort analysis J. Perinat. Med. (IF 2.4) Pub Date : 2024-03-26 Ashraf Gad, Dhafer Malouche, Manoj Chhabra, Danthanh Hoang, Debbie Suk, Nitin Ron, Beata Dygulska, Madhu B. Gudavalli, Ali M. Nadroo, Pramod Narula, Ibrahim Elmakaty
Objectives To investigate the association between birth weight to placental weight (BW/PW) ratio, and echocardiographic left ventricle (LV) morphology at birth, while accounting for other relevant perinatal factors. Methods A prospective cohort study was conducted on neonates at NewYork-Presbyterian Brooklyn Methodist Hospital from 2014 to 2018, categorized by their BW/PW percentile. Missing data were
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Second twin outcome at birth: retrospective analysis in a single tertiary centre in Malaysia J. Perinat. Med. (IF 2.4) Pub Date : 2024-03-21 Rahana Abd Rahman, Azmawati Mohammed Nawi, Shareena Ishak, Kartik Balaraman, Mohamad Azrai Abu, Siti Hajar Abd Azman, Aida Hani Kalok, Nor Azlin Mohamed Ismail, Zaleha Abdullah Mahdy, Shuhaila Ahmad
Objectives To investigate factors associated with outcome of second twin during labour. Methods The study was a retrospective cohort study in a single tertiary centre in Malaysia from 2014 until 2018 involving all twin pregnancies delivered at or more than 24 weeks of gestation. Results Total of 409 twin pregnancies were included. Dichorionic twin comprises of 54.5 % (n=223) and 45.5 % (n=186) are
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Temporal effects of caffeine on intrapulmonary shunt in preterm ventilated infants J. Perinat. Med. (IF 2.4) Pub Date : 2024-03-15 Ourania Kaltsogianni, Ravindra Bhat, Anne Greenough, Theodore Dassios
Objectives We hypothesized that caffeine would be associated with a transient reduction in the right-to-left shunt and VA/Q. We aimed to explore the temporal effects of caffeine on right-to-left shunt, ventilation perfusion ratio (VA/Q) and shift of the oxyhaemoglobin dissociation curve (ODC) in premature ventilated infants. Methods Retrospective cohort study at a tertiary neonatal unit of infants
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Parental refusal of prenatal screening for aneuploidies J. Perinat. Med. (IF 2.4) Pub Date : 2024-03-14 Lynn Bitar, Christian Chaccour, Elio R. Bitar, Rami Halabi, Assaad Kesrouani
Objectives To analyze the reasons for refusal of aneuploidy screening in a multicultural Middle Eastern population. Methods The study included patients delivering in a university hospital, who had refused aneuploidy screening during their pregnancy. We evaluated through a questionnaire submitted during the postpartum period the sociodemographic characteristics, beliefs, attitudes, and the main reason
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Changes in regional tissue oxygen saturation values during the first week of life in stable preterm infants J. Perinat. Med. (IF 2.4) Pub Date : 2024-03-04 Sadaf H. Kazmi, Sourabh Verma, Sean M. Bailey, Pradeep Mally, Purnahamsi Desai
Objectives Near infrared spectroscopy (NIRS) is a non-invasive method for monitoring regional tissue oxygen saturation (rSO2). The purpose of this study is to investigate the changes that occur in cerebral, splanchnic, and renal rSO2 and fractional tissue oxygen extraction (FTOE) in stable preterm infants in the first week of life. Methods Prospective observational study of infants born 30–34 weeks
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The outcome of reduced and non-reduced triplet pregnancies managed in a tertiary hospital during a 15-year-period – a retrospective cohort study J. Perinat. Med. (IF 2.4) Pub Date : 2024-02-29 Riina Maria Jernman, Annu-Riikka Susanna Rissanen, Vedran Stefanovic
Objectives Triplet pregnancies involve several complications, the most important being prematurity as virtually all triplets are born preterm. We conducted this study to compare the outcomes of reduced vs. non-reduced triplet pregnancies managed in the largest tertiary hospital in Finland. Methods This was a retrospective cohort study in the Helsinki University Hospital during 2006–2020. Data on the
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The value of fibrinogen combined with D-dimer and neonatal weight in predicting postpartum hemorrhage in vaginal delivery J. Perinat. Med. (IF 2.4) Pub Date : 2024-02-28 Yanke Zou, Shuai Zeng, Changxiao Huang, Ling Liu, Li Li
Objectives The purpose of this study was to explore whether fibrinogen (Fib) can be used as a predictor of postpartum hemorrhage (PPH) in parturients with vaginal delivery, and the value of combining Fib with other indexes to predict postpartum hemorrhage in vaginal delivery. Methods A total of 207 parturients who delivered via vagina were divided into PPH group (n=102) and non-PPH group (n=105). The
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Preliminary assessment of the Healthy Early Life Moments (HELMS) webinars in empowering Developmental Origins of Health and Disease (DOHaD) concept among healthcare professionals – a pragmatic serial cross-sectional study J. Perinat. Med. (IF 2.4) Pub Date : 2024-02-26 Chee Wai Ku, Roderica R. G. Ng, Ting Yu Chang, Celeste H. F. Lim, Ruther Teo Zheng, Weini Ma, Mei Chien Chua, Jerry K. Y. Chan, Fabian K. P. Yap, See Ling Loy
Objectives The Developmental Origins of Health and Disease (DOHaD) concept has gained prominence in maternal and child health (MCH), emphasizing how early-life factors impact later-life non-communicable diseases. However, a knowledge–practice gap exists in applying DOHaD principles among healthcare professionals. Healthy Early Life Moments in Singapore (HELMS) introduced webinars to bridge this gap
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Correlation of fetal heart rate dynamics to inflammatory markers and brain-derived neurotrophic factor during pregnancy J. Perinat. Med. (IF 2.4) Pub Date : 2024-02-26 Luis Mercado, Shannon Rose, Diana Escalona-Vargas, Eric R. Siegel, Julie R. Whittington, Hubert Preissl, Melissa Helmich, Hari Eswaran
Objectives This study aims to show the relation between biomarkers in maternal and cord-blood samples and fetal heart rate variability (fHRV) metrics through a non-invasive fetal magnetocardiography (fMCG) technique. Methods Twenty-three women were enrolled for collection of maternal serum and fMCG tracings immediately prior to their scheduled cesarean delivery. The umbilical cord blood was collected
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Prediction of bronchopulmonary dysplasia by the chest radiographic thoracic area on day one in infants with exomphalos J. Perinat. Med. (IF 2.4) Pub Date : 2024-02-26 Mirna Krishnan, Theodore Dassios, Zoe Bothamley, Saira Haque, Callum Watson, Mark Davenport, Christopher Harris, Anne Greenough
Objectives To determine if infants with exomphalos had abnormal antenatal lung growth as indicated by lower chest radiographic thoracic areas (CRTA) on day one compared to controls and whether the CRTA could predict the development of bronchopulmonary dysplasia (BPD). Methods Infants with exomphalos cared for between January 2004 and January 2023 were included. The controls were term, newborn infants
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The changing Doppler patterns and perinatal outcomes of monochorionic diamniotic twins with selective fetal growth restriction J. Perinat. Med. (IF 2.4) Pub Date : 2024-02-26 Luyao Li, Xueju Wang, Pengbo Yuan, Yangyu Zhao, Yuan Wei
Objectives To investigate the clinical outcomes and Doppler patterns changes in monochorionic diamniotic (MCDA) twins with selective fetal growth restriction (sFGR). Methods We retrospectively analyzed 362 sFGR cases from January 2010 to May 2016 at a single tertiary referral center. The Doppler waveforms of umbilical artery end-diastolic flow were collected, and all neonates were subjected to an early
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Incidence and first trimester risk factors of stillbirth in Indonesia J. Perinat. Med. (IF 2.4) Pub Date : 2024-02-26 Mirani Ulfa Yusrika, Adly Nanda Al Fattah, Raden Aditya Kusuma, Felix Firyanto Widjaja, Shinda Marizni, Vania Permata Putri
Objectives To determine the incidence and the risk factors of stillbirth from maternal biophysical, ultrasound, and biochemical markers at 11–13 weeks of gestation in the Indonesian population. Methods This was a retrospective cohort study of pregnant women for first-trimester preeclampsia screening at 11–13 weeks of gestation in some clinics and hospital in Jakarta. Maternal characteristics and history
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Coagulation assessment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infected pregnant women and their offspring by using rotational thromboelastometry (ROTEM) J. Perinat. Med. (IF 2.4) Pub Date : 2024-02-14 Georgios Mitsiakos, Dimitra Gialamprinou, Christos-Georgios Kontovazainitis, Athanasios Moraitis, Georgios Katsaras, Abraham Pouliakis, Elissavet Diamanti
Objectives During pregnancy, severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection may intensify the gestational procoagulant state. Coronavirus disease 2019 (COVID-19) associated coagulopathy (CAC) constitutes an exacerbated immunothrombosis response. There is limited data regarding the coagulation profile of SARS-CoV2-infected pregnant women, especially those with CAC, and the effect
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The importance of professional responsibility and fetal viability in the management of abortion J. Perinat. Med. (IF 2.4) Pub Date : 2024-02-12 Frank Chervenak, Renee McLeod-Sordjan, Jonathan D. Moreno, Susan Pollet, Eran Bornstein, Joachim Dudenhausen, Amos Grünebaum
In June 2022, the Dobbs v. Jackson Women’s Health Organization Supreme Court decision ended the constitutional right to the professional practice of abortion throughout the United States. The removal of the constitutional right to abortion has significantly altered the practice of obstetricians and gynecologists across the US. It potentially increases risks to pregnant patients, leads to profound changes
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Subclinical cardiac impairments in fetuses conceived through assisted reproductive technology by speckle tracking echocardiography J. Perinat. Med. (IF 2.4) Pub Date : 2024-01-31 Yipeng Gao, Youbin Deng, Peina Huang, Xueqing Cheng, Ruirui Lu, Yating Fan, Hongyun Liu
Objectives To evaluate the changes of cardiac morphology and function in fetuses conceived through assisted reproductive technologies (ART) by speckle tracking echocardiography. Methods A retrospective study was conducted in 101 spontaneously conceived (SC) fetuses and 99 ART-conceived ones. Fetal echocardiography was performed, fetal cardiac morphology and function were analyzed using two-dimensional
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Multifetal pregnancy reductions and selective fetocide in a tertiary referral center – a retrospective cohort study J. Perinat. Med. (IF 2.4) Pub Date : 2024-01-27 Riina Maria Jernman, Vedran Stefanovic
Objectives Multiple pregnancies involve several complications, most often prematurity, but also higher anomaly rates. Reducing fetuses generally improves pregnancy outcomes. We conducted this study to evaluate the obstetrical and neonatal results after multifetal pregnancy reduction (MFPR) in the largest tertiary hospital in Finland. Methods This retrospective cohort study included all MFPR managed
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Prenatal diagnosis of right aortic arch: associated anomalies and fetal prognosis according to different subtypes J. Perinat. Med. (IF 2.4) Pub Date : 2024-01-27 Gizem Elif Dizdaroğulları, Abdullah Alpınar, Oya Demirci
Objectives Right aortic arch (RAA) is a rare anomaly with an incidence of 0.1 % in the adult population and low-risk fetuses. Our aim in this study was to evaluate associated anomalies and conditions according to subtypes. Methods This was a retrospective study examining consecutive pregnancies diagnosed with RAA in our hospital between 2018 and 2022. Fetuses with RAA were divided into three groups
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Sensitivity of antenatal ultrasound in diagnosing posterior placenta accreta spectrum disorders J. Perinat. Med. (IF 2.4) Pub Date : 2024-01-19 Gabriela Dellapiana, Thalia Mok, Lawrence D. Platt, Neil S. Silverman, Christina S. Han, Tania F. Esakoff
Objectives Optimal management of placenta accreta spectrum (PAS) requires antenatal diagnosis. We sought to evaluate the sensitivity of ultrasound findings suggestive of PAS in detecting posterior PAS. Methods Cohort study of patients with posterior placentation and pathology-confirmed PAS from 2011 to 2020 at a tertiary center. Patients were excluded if ultrasound images were unavailable. Ultrasounds
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Influence of donor characteristics on the milk donation volume and microbiological quality of donated human milk in first 3 years of work of the Croatian human milk bank-retrospective observational study J. Perinat. Med. (IF 2.4) Pub Date : 2024-01-18 Jurjana Novoselac, Branka Golubić Ćepulić, Barbara Kalenić, Anita Pavičić Bošnjak
Objectives Donated human milk is the best possible alternative when mother’s own milk is not available. The aim of this study is to investigate whether there are differences in the milk donation volumes and microbiological quality of donated milk depending on human milk donors (HMDs) characteristics. Methods We analyzed data on the HMDs who donated milk in first three years of work of human milk bank
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Fetal brain development in pregnancies complicated by gestational diabetes mellitus J. Perinat. Med. (IF 2.4) Pub Date : 2024-01-17 Maria Chiara Marra, Ilenia Mappa, Maria Elena Pietrolucci, Jia Li Angela Lu, Francesco D’ Antonio, Giuseppe Rizzo
Objectives Gestational diabetes mellitus (GDM) carries an increased risk of neurocognitive impairment in offsprings. However, the contribution of maternal hyperglycemia in affecting fetal brain development is not fully elucidated yet. The aim of this study was to evaluate fetal brain and sulci development in pregnancies complicated by GDM. Methods Prospective observational study including 100 singleton
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Evaluation of postpartum shock index in hypertensive diseases of pregnancy: a case-control study from a tertiary reference center J. Perinat. Med. (IF 2.4) Pub Date : 2024-01-17 Melek Durak, Atakan Tanaçan, Özgür Kara, Dilek Şahin
Objectives To compare the postpartum shock index (SI) values between pregnant women with hypertensive disease of pregnancy (HDP) and normotensive controls. Methods The present study was conducted in Ankara City Hospital Perinatology Clinic. Postpartum SI was compared between the pregnant women with HDP (n=217) and normotensive controls (n=219). A logistic regression analysis was performed to assess
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The prognostic role of CRL discordance in first trimester ultrasound J. Perinat. Med. (IF 2.4) Pub Date : 2024-01-10 Zacharias Fasoulakis, Kimonas Sapantzoglou, Marianna Theodora, George Daskalakis, Asim Kurjak, Panagiotis Antsaklis
Objectives In the first trimester, intertwin crown-rump length (CRL) discordance has emerged as a notable factor linked to adverse perinatal health effects. It is frequently employed as a basis for counseling parents regarding potential adverse pregnancy outcomes. Despite its established association with adverse outcomes, the significance of CRL discordance in substantially predicting pregnancy problems
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Vertical transmission of SARS-CoV-2 – data from the German COVID-19 related obstetric and neonatal outcome study (CRONOS) J. Perinat. Med. (IF 2.4) Pub Date : 2024-01-04 Nadine Mand, Mario Rüdiger, Matthias Hütten, Rolf Felix Maier, Lars Mense, Ulrich Pecks
Objectives We aimed to determine the frequency of SARS-CoV-2 positivity in newborns born to mothers with peripartum SARS-CoV-2 infection in a German cohort, to identify potential risk factors associated with neonatal SARS-CoV-2 infection, and to present short-term outcomes of newborns with vertical transmission of SARS-CoV-2. Methods Data on women with SARS-CoV-2 infection occurring anytime during
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The association between parental SARS-CoV-2 infection in pregnancy and fetal growth restriction J. Perinat. Med. (IF 2.4) Pub Date : 2023-12-31 Melanie Mitta, Lauren Holt, Suchitra Chandrasekaran, Carolynn Dude
Objectives Although the relationship between maternal viral infections and fetal growth restriction (FGR) is well established, the association between SARS-CoV-2 infection in pregnancy and FGR remains unclear. We investigated the association between SARS-CoV-2 infection in pregnancy and FGR at a single county hospital. Methods We performed a prospective cohort study with cohorts matched by gestational
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Disparities in preconception health indicators in U.S. women: a cross-sectional analysis of the behavioral risk factor surveillance system 2019 J. Perinat. Med. (IF 2.4) Pub Date : 2023-12-26 Rachel Terry, Ashton Gatewood, Covenant Elenwo, Abigail Long, Wendi Wu, Caroline Markey, Shawn Strain, Micah Hartwell
Objectives Optimized preconception care improves birth outcomes and women’s health. Yet, little research exists identifying inequities impacting preconception health. This study identifies age, race/ethnicity, education, urbanicity, and income inequities in preconception health. Methods We performed a cross-sectional analysis of the Center for Disease Control and Prevention’s (CDC) 2019 Behavioral
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Determinants of prematurity in urban Indonesia: a meta-analysis J. Perinat. Med. (IF 2.4) Pub Date : 2023-12-26 Putri Maharani Tristanita Marsubrin, Naufal Arkan Abiyyu Ibrahim, Mohammad Adya Firmansha Dilmy, Yulia Ariani, Budi Wiweko, Rima Irwinda, Achmad Kemal Harzif, Badriul Hegar, Ray Wagiu Basrowi
Objectives Indonesia is the fifth country with the highest number of preterm births worldwide. More than a third of neonatal deaths in Indonesia were attributed to preterm birth. Residential areas affected the occurrence of preterm birth due to differing socioeconomic and environmental conditions. Many studies have investigated the determinants of prematurity in Indonesia, however, most of them were
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Comprehensive appraisal of pregnancy and neonatal outcomes in singleton pregnancies conceived via in vitro fertilization in the USA (2016–2021) J. Perinat. Med. (IF 2.4) Pub Date : 2023-12-21 Liron Bar-El, Erez Lenchner, Moti Gulersen, Samantha Gobioff, Arielle Yeshua, Yael Eliner, Amos Grunebaum, Frank A. Chervenak, Eran Bornstein
Objectives We set out to compare adverse pregnancy and neonatal outcomes in singleton gestations conceived via in vitro fertilization (IVF) to those conceived spontaneously. Methods Retrospective, population-based cohort using the CDC Natality Live Birth database (2016–2021). All singleton births were stratified into two groups: those conceived via IVF, and those conceived spontaneously. The incidence
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Obstetric pulmonary embolism and long-term cardiovascular symptoms: a cross-sectional study in Western Mexico J. Perinat. Med. (IF 2.4) Pub Date : 2023-12-19 America Aime Corona Gutierrez, Elvira Sarahi Michelle Rosas Gomez, Eva Elizabet Camarena Pulido, Luis Javier Lopez Aceves, Mireya Robledo Aceves, Ana Jaqueline Bañuelos Avila
Objectives Pulmonary embolism (PE) is an important cause of maternal mortality. There are several guidelines for its diagnosis and management, but there is little information regarding follow-up and frequency of long-term complications. The aim of the study was to determine the frequency of long-term cardiovascular symptoms in patients who had obstetric PE. Methods Cross-sectional study including patients
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Analysis of maternal mortality in Berlin, Germany – discrepancy between reported maternal mortality and comprehensive death certificate exploration J. Perinat. Med. (IF 2.4) Pub Date : 2023-12-18 Julia Callaghan, Joachim Dudenhausen, Lars Paulson, Lars Hellmeyer, Klaus Vetter, Martina Ziegert, Thorsten Braun, Josefine Theresia Koenigbauer
Objectives The OECD estimates an average maternal mortality rate (MMR) of around 3.4 maternal deaths per 100,000 live births for 2019–2021, based on relevant diagnoses on death certificates. However, Germany does not currently have a registry for recording the number of maternal deaths. The aim of this study is to identify the actual number of maternal deaths in Berlin between 2019 and 2022, as well
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Cervical length as a screening tool for preterm birth in twin pregnancies: a systematic review and critical evaluation of quality clinical practice guidelines J. Perinat. Med. (IF 2.4) Pub Date : 2023-12-18 Marika De Vito, Jessica Cetraro, Giulia Capannolo, Sara Alameddine, Chiara Patelli, Francesco D’Antonio, Giuseppe Rizzo
Objectives Twin pregnancies are at increased risk of preterm birth (PTB) compared to singletons. Evaluation of cervical length (CL) represents the optimal tool to screen PTB in singleton. Conversely, there is less evidence on the use of CL in twins. Our aim was to evaluate the methodological quality and clinical heterogeneity of clinical practice guidelines (CPGs) on the CL application in twins using
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Analysis of gastric fluid in preterm newborns supports the view that the amniotic cavity is sterile before the onset of parturition: a retrospective cohort study J. Perinat. Med. (IF 2.4) Pub Date : 2023-12-16 Kyong-No Lee, Hyun Ji Choi, Ha Lim Shin, Hyeon Ji Kim, Jee Yoon Park, Young Hwa Jung, Kyung Joon Oh, Chang Won Choi
Objectives To compare the frequency of Ureaplasma-positive gastric fluid (GF) cultures based on the cause and mode of delivery in preterm newborns. Methods This retrospective cohort study included women with a singleton pregnancy who delivered prematurely (between 23+0 and 32+0 weeks of gestation, n=464) at a single university hospital in South Korea. The newborns’ GF was obtained on the day of birth
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Clinical characteristics and outcomes of women with adenomyosis pain during pregnancy: a retrospective study J. Perinat. Med. (IF 2.4) Pub Date : 2023-12-14 Seisuke Sayama, Takayuki Iriyama, Yotaro Takeiri, Ayako Hashimoto, Masatake Toshimitsu, Mari Ichinose, Takahiro Seyama, Kenbun Sone, Keiichi Kumasawa, Takeshi Nagamatsu, Kaori Koga, Yutaka Osuga
Objectives Adenomyosis is associated with unfavorable perinatal outcomes, and recent case reports show that some women with adenomyosis experience pain at the adenomyosis lesion during pregnancy and have detrimental perinatal outcomes. This study aimed to clarify the clinical characteristics of this pain and perinatal outcomes associated with this phenomenon. Methods This was a single-center retrospective
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The association between obesity and the success of trial of labor after cesarean delivery (TOLAC) in women with past vaginal delivery J. Perinat. Med. (IF 2.4) Pub Date : 2023-12-14 Eiman Shalabna, Reuven Kedar, Wisam Assaf, Chen Nahshon, Nir Kugelman, Ofer Lavie, Lena Sagi-Dain
Objectives To evaluate the effect of overweight (body mass index; BMI 25.0–29.9 kg/m2), and obesity (BMI>30 kg/m2), on the success of trial of labor after cesarean delivery (TOLAC), with consideration of successful past vaginal birth. Methods This retrospective cohort study was performed using electronic database of obstetrics department at a university-affiliated tertiary medical center. All women
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A multivariable prediction model for intra-amniotic infection in patients with preterm labor and intact membranes including a point of care system that measures amniotic fluid MMP-8 J. Perinat. Med. (IF 2.4) Pub Date : 2023-12-14 Teresa Cobo, Silvia Ferrero, Anna Haavisto, Paula Luokola, Ana B. Sanchez-Garcia, Jordi Bosch, Amadeu Gené, Clara Murillo, Claudia Rueda, Bernardino González-de la Presa, Susana Santamaria, Júlia Ponce, David Boada, Montse Palacio
Objectives Among patients with preterm labor and intact membranes (PTL), those with intra-amniotic infection (IAI) present the highest risk of adverse perinatal outcomes. Current identification of IAI, based on microbiological cultures and/or polymerase chain reaction amplification of the 16S ribosomal RNA gene, delay diagnosis and, consequently, antenatal management. The aim to of the study was to
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Left atrial strain in fetal echocardiography – could it be introduced to everyday clinical practice? J. Perinat. Med. (IF 2.4) Pub Date : 2023-12-13 Edin Medjedovic, Zijo Begic, Milan Stanojevic, Buena Aziri, Edin Begic, Milan Djukic, Zorica Mladenovic, Asim Kurjak
Objectives Prenatal cardiology is a part of preventive cardiology based on fetal echocardiography and fetal interventional cardiology, which facilitates treatment of congenital heart defects (CHD) in pediatric patients and consequently in adults. Timely prenatal detection of CHD plays a pivotal role in facilitating the appropriate referral of pregnant women to facilities equipped to provide thorough
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Amniotic fluid embolism: a reappraisal J. Perinat. Med. (IF 2.4) Pub Date : 2023-12-12 Bruce K. Young, Pascalle Florine Magdelijns, Judith L. Chervenak, Michael Chan
Objectives Using cases from our own experience and from the published literature on amniotic fluid embolism (AFE), we seek to improve on existing criteria for diagnosis and discern associated risk factors. Additionally, we propose a novel theory of pathophysiology. Methods This retrospective case review includes eight cases of AFE from two hospital systems and 21 from the published literature. All
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The effect of uterine closure technique on cesarean scar niche development after multiple cesarean deliveries J. Perinat. Med. (IF 2.4) Pub Date : 2023-12-11 Jessica A. Meyer, Jenna Silverstein, Ilan E. Timor-Tritsch, Clarel Antoine
Objectives To use saline infusion sonohysterography (SIS) to evaluate the effect of uterine closure technique on niche formation after multiple cesarean deliveries (CDs). Methods Patients with at least one prior CD were evaluated for niche via SIS. Subgroups of any number repeat CD (>1 prior), lower-order CD (<4 prior), and higher-order CD (≥4 prior) were analyzed, stratifying by hysterotomy closure
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Pathogenic recurrent copy number variants in 7,078 pregnancies via chromosomal microarray analysis J. Perinat. Med. (IF 2.4) Pub Date : 2023-12-11 Han Kang, Yifei Chen, Lingxi Wang, Chonglan Gao, Xingyu Li, Yu Hu
Objectives To investigate the incidence of pathogenic recurrent CNVs in fetuses with different referral indications and review the intrauterine phenotypic features of each CNV. Methods A total of 7,078 amniotic fluid samples were collected for chromosome microarray analysis (CMA) and cases carrying pathogenic recurrent CNVs were further studied. Results The highest incidence of pathogenic recurrent
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Artificial intelligence in the NICU to predict extubation success in prematurely born infants J. Perinat. Med. (IF 2.4) Pub Date : 2023-12-07 Allan C. Jenkinson, Theodore Dassios, Anne Greenough
Objectives Mechanical ventilation in prematurely born infants, particularly if prolonged, can cause long term complications including bronchopulmonary dysplasia. Timely extubation then is essential, yet predicting its success remains challenging. Artificial intelligence (AI) may provide a potential solution. Content A narrative review was undertaken to explore AI’s role in predicting extubation success
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Comparison between trans-vaginal and trans-abdominal ultrasound examination of the cervix in the second trimester of pregnancy: a prospective study J. Perinat. Med. (IF 2.4) Pub Date : 2023-11-09 Davide Calandra, Martina Mercaldi, Marika De Vito, Danilo Buca, Marco Liberati, Alessandra Lucidi, Giuseppe Rizzo, Francesco D’Antonio
Objectives To compare transvaginal (TV) and trans-abdominal (TA) ultrasound assessment of cervical length (CL) at the time of the second-trimester scan for fetal anomalies. Methods This was a prospective study including consecutive pregnant women attending the low-risk ultrasound clinic of two fetal medicine centres in Italy. The inclusion criteria were women between 19 + 0 and 22 + 0 weeks of gestation
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Validation of an automated software (Smartpelvic™) in assessing hiatal area from three dimensional transperineal pelvic volumes of pregnant women: comparison with manual analysis J. Perinat. Med. (IF 2.4) Pub Date : 2023-11-08 Serena Resta, Marika De Vito, Chiara Patelli, Jia Li Angela Lu, Gianluca Gabrielli, Erika Chiodo, Ilenia Mappa, Giuseppe Rizzo
Objectives The aim of this investigation was to evaluate the agreement between a manual and an automatic technique in assessing levator hiatus area (LHA) during pregnancy from three-dimensional (3D) pelvic floor volumes obtained by trans-perineal ultrasound (TPUS). Methods 3D volumes were acquired during rest, maximum pelvic floor contraction and Valsalva maneuver from 66 pregnant women. Manual selection
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Changes circMyt1l/rno-let-7d-5p/brain-derived neurotrophic factor a damaged periventricular white matter damage model in neonatal rats J. Perinat. Med. (IF 2.4) Pub Date : 2023-11-08 Lihua Zhu, Yiwen Han, Jiaping Shu
Objectives To investigate the function of circMyt1l/rno-let-7d-5p/BDNF in the white matter damage of premature rats. Methods Bioinformatic analysis was used to analyze the differential expression of circMyt1l and its interacting miRNAs and mRNAs in rats with periventricular white matter damage. Rats at postnatal day 3 had their right common carotid artery permanently ligated, and were then exposed
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Effects of sildenafil on Doppler parameters, maternal and neonatal outcomes in the active labor phase of low-risk pregnancies: a randomized clinical trial J. Perinat. Med. (IF 2.4) Pub Date : 2023-11-06 Vajiheh Marsosi, Ladan Haghighi, Parinaz Hamed Nasimi, Marjan Ghaemi, Saimaz Navaee
Objectives The benefits of sildenafil by increasing blood flow in the improvement of Doppler parameters of umbilical (UA), uterine (UtA), and fetal middle cerebral arteries (MCA) remain uncertain. On the other hand, insufficient blood flow during uterine contractions in labor can lead to decrease blood supply and fetal distress. Therefore, we aimed to assess the changes in fetal Doppler indices and
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The impact of the COVID-19 pandemic on antenatal care provision and associated mental health, obstetric and neonatal outcomes J. Perinat. Med. (IF 2.4) Pub Date : 2023-10-26 Anousha Woods, Emma Ballard, Sailesh Kumar, Tracey Mackle, Leonie Callaway, Alka Kothari, Susan De Jersey, Elizabeth Bennett, Katie Foxcroft, Meg Willis, Akwasi Amoako, Christoph Lehner
Objectives The COVID-19 pandemic imposed many challenges on pregnant women, including rapid changes to antenatal care aimed at reducing the societal spread of the virus. This study aimed to assess how the pandemic affected perinatal mental health and other pregnancy and neonatal outcomes in a tertiary unit in Queensland, Australia. Methods This was a retrospective cohort study of pregnant women booked
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Collaboration between maternal-fetal medicine and family planning: a survey of Northeast US academic medical centers J. Perinat. Med. (IF 2.4) Pub Date : 2023-10-19 Audrey A. Merriam, Lisbet Lundsberg, Abigail S. Cutler, Theresa Maxam, Maureen Paul
Objectives To explore how complex family planning (CFP) and maternal-fetal medicine (MFM) in Northeast academic medical centers work together to provide abortion care. Methods We distributed an exploratory cross-sectional online survey to CFP and MFM faculty and fellows at academic medical centers in the Northeast between July and September of 2020. The survey included demographic information, assessment
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The evaluation of fetal interventricular septum with M-mode and spectral tissue Doppler imaging in gestational diabetes mellitus: a case-control study J. Perinat. Med. (IF 2.4) Pub Date : 2023-10-19 Deniz Oluklu, Dilek Menekse Beser, Derya Uyan Hendem, Muradiye Yildirim, Duygu Tugrul Ersak, Ezgi Turgut, Dilek Sahin
Objectives To demonstrate possible functional changes in the frequently affected fetal interventricular septum (IVS) with spectral tissue Doppler imaging (TDI) and M-mode imaging to compare gestational diabetes mellitus (GDM) and control groups. Methods A total of 63 pregnant women with GDM, 30 on diet (A1 GDM) and 33 on treated with insulin (A2 GDM), and 63 healthy pregnant women randomly selected
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Umbilical cord blood hematological parameters in predicting early onset neonatal sepsis (EOS) – a prospective cohort study J. Perinat. Med. (IF 2.4) Pub Date : 2023-10-19 Smrithi Marie Samson, Chandramohan Anandhi, Rathi Sharmila Ramar
Objectives In low and middle income countries, there is a need for affordable and accurate biomarkers to identify neonates at risk of early onset neonatal sepsis (EOS). Cord blood hematological parameters if reliable and accurate for the detection of EOS are cost effective and can reduce the need for repeated venipuncture in the neonate. Methods In this prospective cohort study, the umbilical cord
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Association of low pregnancy associated plasma protein-A with increased umbilical artery pulsatility index, in cases of fetal weight between the 3rd and 10th percentiles: a retrospective cohort study J. Perinat. Med. (IF 2.4) Pub Date : 2023-10-19 Carolina Dias da Silva, Inês Sarmento Gonçalves, Carla Ramalho
Objectives This study aims to evaluate if low levels of serum maternal pregnancy associated plasma protein-A (PAPP-A) during the first trimester are related to increased umbilical artery pulsatility index (UA PI) later in pregnancy, in cases of estimated fetal weight between the 3rd and 10th percentiles, in order to establish PAPP-A as a predictor of this particular cases of fetal growth restriction
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Effects of gender on fetal cortical development: a secondary analysis of a prospective cross-sectional study J. Perinat. Med. (IF 2.4) Pub Date : 2023-10-18 Ilenia Mappa, Maria Chiara Marra, Maria Elena Pietrolucci, Jia Li Angela Lu, Daniele Di Mascio, Francesco D’Antonio, Giuseppe Rizzo
Objectives The primary objective was to evaluate the effects of fetal sex on fetal cortical development in low-risk pregnancies. Secondary objective was the evaluate the impact of gestational age. Methods This was a secondary analysis of a prospective cross-sectional study on low-risk fetuses undergoing fetal neurosonography between 19 and 34 weeks of gestation. The depth of Sylvian Fissure (SF), Parieto
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The association between maternal colonization with Group B streptococcus and infectious morbidity following transcervical Foley catheter-assisted labor induction J. Perinat. Med. (IF 2.4) Pub Date : 2023-10-18 Alon Ben-David, Raanan Meyer, Shali Mazaki-Tovi
Objectives To determine whether maternal colonization with Group B streptococcus increases the risk for infectious morbidity following transcervical Foley catheter-assisted cervical ripening. Methods A retrospective cohort study comparing infectious morbidity and other clinical outcomes by Group B streptococcus colonization status between all women with singleton pregnancies who underwent Foley catheter-assisted
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Genetic analysis, ultrasound phenotype, and pregnancy outcomes of fetuses with Xp22.33 or Yp11.32 microdeletions J. Perinat. Med. (IF 2.4) Pub Date : 2023-10-17 Meiying Cai, Xuemei Chen, Ying Li, Na Lin, Hailong Huang, Liangpu Xu
Objectives The phenotypes of Xp22.33 or Yp11.32 microdeletions comprising the short-stature homeobox (SHOX) gene have been extensively described in adults and children. Herein, the prenatal ultrasound phenotype and pregnancy outcomes of fetuses with Xp22.33/Yp11.32 microdeletions were analyzed to improve our understanding, diagnosis, and monitoring of this genetic condition in the fetal stage. Methods
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Hepatic arterial buffer response: activation in donor fetuses and the effect of laser ablation of intertwin anastomosis J. Perinat. Med. (IF 2.4) Pub Date : 2023-10-17 Jader de Jesus Cruz, Joana Bernardeco, Claudia Rijo, Alvaro Cohen, Fatima Serrano
Objectives Hepatic arterial buffer response (HABR) is an important defence mechanism for maintaining liver blood flow. It is suspected that HABR is active in monochorionic diamniotic twins (MCDA) with twin-to-twin transfusion syndrome (TTTS) where donor compensates a setting of volume depletion and the recipient an overload. The present study investigates whether in TTTS, HABR is active in donor and/or
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Pregnancy and neonatal outcomes of SARS-CoV-2 infection discovered at the time of delivery: a tertiary center experience in North Italy J. Perinat. Med. (IF 2.4) Pub Date : 2023-10-17 Alessandro Libretti, Libera Troìa, Anna Maria Cappello, Carolina Casarotti, Alessia Tony D’Amato, Gloria Dallarda, Matilda Ghio, Anthony Nicosia, Daria Ricci, Federica Savasta, Michela Sonzini, Diletta Villa, Alberto De Pedrini, Daniela Surico, Valentino Remorgida
Objectives Although the knowledge on SARS-CoV-2 infection in pregnancy has greatly improved, there is still a lack of information on its role in the later stages of gestation. The aim of this study is to investigate whether SARS-CoV-2 discovered at delivery is associated with any obstetric or neonatal complications. Methods A retrospective case-control study was conducted at Department of Obstetrics
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Down-regulated Wnt7a and GPR124 in early-onset preeclampsia placentas reduce invasion and migration of trophoblast cells J. Perinat. Med. (IF 2.4) Pub Date : 2023-09-11 Yan Shen, Qingyu Cui, Li Xiao, Lifeng Wang, Qianqian Li, Ruihong Zhang, Zhaowen Chen, Jianmin Niu
Objectives Preeclampsia (PE) is a disease specific to pregnancy that causes 9–10 % of maternal deaths. Early-onset PE (<34 weeks’ gestation) is the most dangerous category of PE. Wnt7a and GPR124 (G protein-coupled receptor 124) are widely expressed in the human reproductive process. Especially during embryogenesis and tumorigenesis, Wnt7a plays a crucial role. However, few studies have examined the
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Pregnancy, delivery and neonatal outcomes in women with gastrointestinal system cancer in pregnancy. An evaluation of a population database J. Perinat. Med. (IF 2.4) Pub Date : 2023-09-07 Uri Amikam, Ahmad Badeghiesh, Haitham Baghlaf, Richard Brown, Michael H. Dahan
Objectives Gastrointestinal system (GIS) cancer in pregnancy is a rare disease. Our aim was to evaluate the association between this type of cancer and pregnancy, delivery and neonatal outcomes. Methods We conducted a retrospective population-based cohort study using the Healthcare Cost and Utilization Project, Nation-wide Inpatient Sample (HCUP-NIS). We included all women who delivered or had a maternal
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Maternal and neonatal complications in pregnancies with and without pre-gestational diabetes mellitus J. Perinat. Med. (IF 2.4) Pub Date : 2023-09-07 Rebecca Karkia, Tara Giacchino, Helen Watson, Andrew Gough, Ghada Ramadan, Ranjit Akolekar
Objectives To compare pregnancy complications in pregnancies with and without pre-gestational diabetes mellitus (DM) managed in a multidisciplinary high-risk diabetes antenatal clinic. Methods This screening cohort study was undertaken at a large maternity unit in the United Kingdom between January 2010 and December 2022. We included singleton pregnancies that booked at our unit at 11–13 weeks’ gestation
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Carboxyhaemoglobin levels in infants with hypoxic ischaemic encephalopathy J. Perinat. Med. (IF 2.4) Pub Date : 2023-08-31 Allan Jenkinson, Sarah Zaidi, Ravindra Bhat, Anne Greenough, Theodore Dassios
Objectives Hypoxic ischaemic encephalopathy (HIE) is associated with oxidative stress. A potential marker of oxidative damage is carboxyhaemoglobin (COHb) which is the product of the reaction between carbon monoxide and haemoglobin and is routinely assessed on blood gas analysis. Our objective was to test the hypothesis that higher COHb levels would be associated with worse outcomes in infants treated
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The impact of abnormal maternal body mass index during pregnancy on perinatal outcomes: a registry-based study from Qatar J. Perinat. Med. (IF 2.4) Pub Date : 2023-08-24 Ghinwa Lawand, Fathima Minisha, Salwa Abu Yaqoub, Nader Al Dewik, Hilal Al Rifai, Thomas Farrell
Objectives Abnormal body mass index (BMI) during pregnancy, a growing public health concern, increases maternal and neonatal complications. This study aimed to investigate the impact of abnormal BMI on perinatal outcomes compared to normal BMI. Methods A total of 14,624 women having singleton births were categorized as underweight (BMI<18.5 kg/m2), overweight (25.0–29.9 kg/m2), obesity class I (30
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Enhanced recovery after cesarean from the patient perspective: a prospective study of the ERAC Questionnaire (ERAC-Q) J. Perinat. Med. (IF 2.4) Pub Date : 2023-08-23 Jessica A. Meyer, Suzanne Alton, Hyunuk Seung, Autusa Pahlavan, Ariel R. Trilling, Martha Coghlan, Katherine R. Goetzinger, Liviu Cojocaru
Objectives To evaluate the impact of an Enhanced Recovery After Cesarean (ERAC) protocol on the post-cesarean recovery experience using a validated ten-item questionnaire (ERAC-Q). Methods This is a prospective cohort study of patients completing ERAC quality-of-life questionnaires (ERAC-Q) during inpatient recovery after cesarean delivery (CD) between October 2019 and September 2020, before and after