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Acinar Dysplasia in a Full-Term Newborn with a NKX2.1 Variant. Neonatology (IF 2.5) Pub Date : 2023-11-30 Yohan Soreze,Nadia Nathan,Julien Jegard,Erik Hervieux,Pauline Clermidi,Chiara Sileo,Camille Louvrier,Marie Legendre,Aurore Coulomb L'Herminé
Acinar dysplasia (AcDys) is one of the three main diffuse developmental disorders of the lung. The transcription factor NK2 homeobox 1 (NKX2.1) partly controls the synthesis of surfactant proteins by type 2 alveolar epithelial cells (AEC2), and germline mutations are known to be associated with brain-lung thyroid syndrome. We report the case of a full-term neonate who developed refractory respiratory
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Associations of High-Sensitive Cardiac Troponin T in Healthy Newborns and Prolonged Second Stage of Labor, Neonatal and Maternal Factors: A Prospective Study. Neonatology (IF 2.5) Pub Date : 2023-11-28 Leena Kassem,Abed Athamna,Rami Abu Fanne,Yana Tal,Adi Klein,Sarit Freimann,David Haim,Maanit Shapira,Wasef Na'amnih,Eias Kassem
INTRODUCTION High-sensitivity cardiac troponin T (hs-cTnT) is not used routinely as a diagnostic biomarker in newborns. The high precision of hs-cTnT assays increases the ability to determine small differences in cTnT over time and to detect troponin T elevation; thus, we believe that hs-cTnT assays might improve clinical care. We explored the plausible association between hs-cTnT levels (ng/L) in
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Clinical Features, Diagnosis, and Treatment of Congenital and Neonatal Tuberculosis: A Retrospective Study. Neonatology (IF 2.5) Pub Date : 2023-11-27 Yujiao Zhou,Kun Zhu,Xiayi Zhang,Zheyi Zhu,Li Jiang,Linlin Xing,Binyue Xu,TingTing Ai,Quanbo Liu,Ruiqiu Zhao,Ximing Xu,Juan Chen,Zhenzhen Zhang
INTRODUCTION Limited studies have explored the clinical features, treatment, and prognosis of neonatal tuberculosis (TB). Here, we attempted to delineate the clinical characteristics of neonatal TB, which may help clinicians further understand this disease. METHODS A retrospective analysis of neonates diagnosed with congenital and/or neonatal TB disease from January 2010 to December 2020 was performed
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Early versus Late Caffeine Therapy Administration in Preterm Neonates: An Updated Systematic Review and Meta-Analysis. Neonatology (IF 2.5) Pub Date : 2023-11-21 Vanessa Karlinski Vizentin,Isabela Madeira de Sá Pacheco,Thalita Fahel Vilas Bôas Azevêdo,Cynthia Florêncio de Mesquita,Rafael Alvim Pereira
BACKGROUND Caffeine is commonly used as therapy for apnea of prematurity and has shown potential in preventing other conditions in preterm neonates. However, the optimal timing for caffeine therapy remains uncertain. OBJECTIVE This study aimed to compare the outcomes of early versus late administration of caffeine in preterm neonates. METHODS PubMed, Embase, and Cochrane Library were searched for studies
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Enhanced Category-Based Risk Assessment for Neonatal Early-Onset Sepsis: A Prospective Observational Study. Neonatology (IF 2.5) Pub Date : 2023-10-31 Hoi Ying Sharon Lau,Xuelian Wang,Ho Tsun Michelia Wong,Ka Hei Catherine Lam,Hugh Simon Lam
INTRODUCTION Compared with multivariate risk assessment, traditional category-based risk assessment (CRA) approaches for neonatal early-onset sepsis (EOS) screening are usually straightforward to use, do not require electronic devices, but are associated with higher rates of antibiotic use. This study aims to evaluate the performance of a novel enhanced CRA (eCRA) framework on EOS admissions and antibiotic
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Aortic Steal Correlates with Acute Organ Dysfunction and Short-Term Outcomes in Neonates with Vein of Galen Malformation. Neonatology (IF 2.5) Pub Date : 2023-10-31 Simone Schwarz,Francisco Brevis Nuñez,Nikola R Dürr,Martin Schlunz-Hendann,Friedhelm Brassel,Ursula Felderhoff-Müser,Christian Dohna-Schwake,Nora Bruns
INTRODUCTION Vein of Galen aneurysmal malformation (VGAM) is a rare, congenital cerebrovascular malformation with high morbidity and mortality. Parameters to foresee clinical progression and allow individualized parent counseling are lacking. The aim of this study was to evaluate aortic steal measured by Doppler ultrasound as a prognostic parameter in these neonates. METHODS A retrospective monocentric
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Diagnostic Accuracy of Urinary N Terminal pro-B Type Natriuretic Peptides for Hemodynamically Significant-Patent Ductus Arteriosus in Preterm Infants. Neonatology (IF 2.5) Pub Date : 2023-10-27 Srirupa Hari Gopal,Ganga Gokulakrishnan,Madhulika Kulkarni,Caraciolo J Fernandes,Mohan Pammi
BACKGROUND Echocardiography is the gold standard for the diagnosis hemodynamically significant-patent ductus arteriosus (hs-PDA). It requires trained personnel and is not readily available. Urinary biomarkers can be used as an adjunct. OBJECTIVE The objective of this study was to systematically review the diagnostic accuracy of urinary N terminal pro-B type natriuretic peptides (NT-proBNP) for hs-PDA
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External Validation of a Multivariate Model for Targeted Surfactant Replacement. Neonatology (IF 2.5) Pub Date : 2023-10-26 Francesco Raimondi,Pasquale Dolce,Claudio Veropalumbo,Enrico Sierchio,Rebeca Gregorio Hernandez,Javier Rodriguez Fanjul,Fabio Meneghin,Roberto Raschetti,Luca Bonadies,Iuri Corsini,Almudena Alonso Ojembarrena,Serena Salomè,Lorena Rodeño Fernandez,Manuel Sanchez Luna,Gianluca Lista,Fabio Mosca,Carlo Dani,Eugenio Baraldi,Lucio Giordano,Peter G Davis,Letizia Capasso
INTRODUCTION Early targeted surfactant therapy for preterm infants is recommended but the best criteria to personalize treatment are unclear. We validate a previously published multivariate prognostic model based on gestational age (GA), lung ultrasound score (LUS), and oxygen saturation to inspire oxygen fraction ratio (SatO2/FiO2) using an independent data set. METHODS Pragmatic, observational study
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Outcomes at 18-24 Months of Infants with Birth Weight under 500 g Born in Korea during 2013-2017: A Nationwide Cohort Study. Neonatology (IF 2.5) Pub Date : 2023-10-20 Soo Hyun Kim,Euiseok Jung,Ha Na Lee,Jeong Min Lee,Sung Hyeon Park,Jiyoon Jeong,Byong Sop Lee,Ellen Ai-Rhan Kim,Ki-Soo Kim
INTRODUCTION This study aimed to investigate the outcomes of infants at 18-24 months born in the Korean Neonatal Network with a birth weight <500 g. METHODS The anthropometric and neurodevelopmental data of infants with a birth weight <500 g at a gestational age of ≥22 weeks who were registered in the Korean Neonatal Network 2013-2017 and followed up at a corrected age of 18-24 months were reviewed
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Long-Term Neurodevelopmental Impairment among Very Preterm Infants with Sepsis, Meningitis, and Intraventricular Hemorrhage. Neonatology (IF 2.5) Pub Date : 2023-10-20 Qi Zhou,Melissa Ong,Xiang Y Ye,Joseph Y Ting,Prakesh S Shah,Anne Synnes,Thuy Mai Luu,Shoo Lee,
INTRODUCTION Sepsis and intraventricular hemorrhage (IVH) are associated with poorer long-term neurodevelopmental outcomes in very preterm infants (VPIs), but less is known about the long-term effect of meningitis and the combined impact of both meningitis and IVH. Our objective was to examine the long-term neurodevelopmental outcomes of VPIs with late onset sepsis and meningitis, with and without
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Magnetic Resonance Imaging-Based Reference Values for Two-Dimensional Quantitative Brain Metrics in a Cohort of Extremely Preterm Infants. Neonatology (IF 2.5) Pub Date : 2023-10-20 Julia Buchmayer,Gregor Kasprian,Raphaela Jernej,Sophie Stummer,Victor Schmidbauer,Vito Giordano,Katrin Klebermass-Schrehof,Angelika Berger,Katharina Goeral
INTRODUCTION Cerebral magnetic resonance imaging (cMRI) is an important diagnostic tool in neonatology. In addition to qualitative analysis, quantitative measurements may help identify infants with impaired brain growth. This study aimed to create reference values for brain metrics of various brain areas in neonates without major brain injuries born before 28 weeks of gestation. METHODS This retrospective
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Risk Factors for Neurodevelopmental Impairment at 2- and 5-Years Corrected Age in Preterm Infants with Established Bronchopulmonary Dysplasia. Neonatology (IF 2.5) Pub Date : 2023-10-18 Trixie A Katz,Anton H van Kaam,Suzanne M Mugie,Cornelieke S H Aarnoudse-Moens,Femke de Groof,Anne A M W van Kempen,Maria E N van den Heuvel,Judith Vogelzang,Maarten Rijpert,Irene A Schiering,Irene Koomen-Botman,Fenna Visser,Aleid G Leemhuis,Wes Onland
INTRODUCTION The objective of this study was to identify risk factors for neurodevelopmental impairment (NDI) at 2- and 5-years corrected age (CA) in a cohort of preterm infants with established bronchopulmonary dysplasia (BPD). METHODS This single-center retrospective cohort study included infants born between 2009 and 2016 at a gestational age (GA) <30 weeks with moderate or severe BPD at 36 weeks'
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Hospital Variation in Mortality and Failure to Rescue after Surgery for High-Risk Neonatal Diagnoses. Neonatology (IF 2.5) Pub Date : 2023-10-16 Steven C Mehl,Jorge I Portuondo,Yao Tian,Mehul V Raval,Alice King,Kristy L Rialon,Adam M Vogel,David E Wesson,Sohail R Shah,Nader N Massarweh
INTRODUCTION A large proportion of postoperative mortality after pediatric surgery occurs among neonates with specific high-risk diagnoses. The extent to which there is hospital-level mortality variation among patients with these diagnoses and whether this variation is associated with differences in failure to rescue (FTR) is unclear. METHODS The Pediatric Health Information System® database (2012-2020)
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Parental Experiences of Neonatal Care: A Nationwide Study on Determinants of Excellence. Neonatology (IF 2.5) Pub Date : 2023-10-16 Agnes Linnér,Ylva Thernström Blomqvist,Kristina Jonsson,Siri Lilliesköld,Mikael Norman
INTRODUCTION Infant- and family-centered developmental care can reduce adverse outcomes in both infants and parents. Parents' experiences of the care and staff treatment remain to be evaluated. METHODS Parents of infants admitted to neonatal units in Sweden from July 2020 to May 2022 responded to a questionnaire with standardized questions about in-hospital care. Exposures were hospital, gestational
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Neuro-Specific and Immuno-Inflammatory Biomarkers in Umbilical Cord Blood in Neonatal Hypoxic-Ischemic Encephalopathy. Neonatology (IF 2.5) Pub Date : 2023-09-29 Hanna Toorell,Ylva Carlsson,BouBou Hallberg,Mairead N O'Riordian,Brian Henry Walsh,Marc Paul O'Sullivan,Geraldine B Boylan,Henrik Zetterberg,Kaj Blennow,Deirdre Murray,Henrik Hagberg
OBJECTIVES The aim of the study was to evaluate neuronal injury and immuno-inflammatory biomarkers in umbilical cord blood (UCB) at birth, in cases with perinatal asphyxia with or without hypoxic-ischemic encephalopathy (HIE), compared with healthy controls and to assess their ability to predict HIE. STUDY DESIGN In this case-control study, term infants with perinatal asphyxia were recruited at birth
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Time of Delivery Contributes to Mortality and Morbidity in Preterm Infants. Neonatology (IF 2.5) Pub Date : 2023-09-27 Tiina Teivaanmäki,Lotta Hallamaa,Krista Rantakari,Sture Andersson,Markus Leskinen
INTRODUCTION Knowledge about the time of birth and its impact on premature infants is essential when planning perinatal and neonatal care and resource allocation. We studied the time of birth and its contribution to early death and morbidity in preterm infants. METHODS We explored the time and mode of birth of infants with birthweight of <1,500 g and gestational age of <32+0/7 weeks. Additionally,
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Evaluation of the Neonatal Sequential Organ Failure Assessment and Mortality Risk in Neonates with Early-Onset Infection. Neonatology (IF 2.5) Pub Date : 2023-09-27 Kee Thai Yeo,Guan Lin Goh,Woo Yeon Park,James L Wynn,Khyzer B Aziz
BACKGROUND The discriminative utility of the neonatal sequential organ failure assessment (nSOFA) for early-onset sepsis (EOS) mortality in the neonatal intensive care unit (NICU) is unknown. OBJECTIVES The objective of the study was to determine the utility of nSOFA for EOS mortality. METHODS Multicenter, retrospective cohort study of NICU patients with EOS between 2012 and 2023. nSOFA scores of survivors
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Effects of Milrinone on Neonates after Patent Ductus Arteriosus Ligation: A Retrospective Nationwide Database Study. Neonatology (IF 2.5) Pub Date : 2023-09-27 Hiroki Kitaoka,Takaaki Konishi,Yoshihiko Shitara,Atsushi Ito,Kohei Kashima,Asahi Fujita,Hiroki Matsui,Motohiro Kato,Naoto Takahashi,Hideo Yasunaga
INTRODUCTION Milrinone is administered after patent ductus arteriosus (PDA) ligation to prevent and treat postoperative hemodynamic instability (i.e., postligation cardiac syndrome). We aimed to explore the effectiveness of milrinone on in-hospital outcomes in infants who underwent PDA ligation using a nationwide inpatient database in Japan. METHODS Using the Japanese Diagnosis Procedure Combination
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Placental Histologic Abnormalities and 2-Year Outcomes in Neonatal Hypoxic-Ischemic Encephalopathy. Neonatology (IF 2.5) Pub Date : 2023-09-22 Fernando F Gonzalez,Emily Voldal,Bryan A Comstock,Dennis E Mayock,Amy M Goodman,Marie-Coralie Cornet,Tai-Wei Wu,Raymond W Redline,Patrick Heagerty,Sandra E Juul,Yvonne W Wu
OBJECTIVE We aimed to examine the association between placental abnormalities and neurodevelopmental outcomes in a multicenter cohort of newborn infants with hypoxic-ischemic encephalopathy (HIE) that underwent therapeutic hypothermia. We hypothesized that subjects with acute placental abnormalities would have reduced risk of death or neurodevelopmental impairment (NDI) at 2 years of age after undergoing
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An Early Prediction Model for Estimating Bronchopulmonary Dysplasia in Preterm Infants. Neonatology (IF 2.5) Pub Date : 2023-09-19 Yasemin Ezgi Kostekci,Batuhan Bakırarar,Emel Okulu,Omer Erdeve,Begum Atasay,Saadet Arsan
INTRODUCTION Accurate assessment of the risk for bronchopulmonary dysplasia (BPD) is critical to determine the prognosis and identify infants who will benefit from preventive therapies. Clinical prediction models can support the identification of high-risk patients. In this study, we investigated the potential risk factors for BPD and compared machine learning models for predicting the outcome of BPD/death
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Commentary on "Early (<7 Days) Systemic Postnatal Corticosteroids for Prevention of Bronchopulmonary Dysplasia in Preterm Infants". Neonatology (IF 2.5) Pub Date : 2023-09-12 Nicolas A Bamat,Roger F Soll
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Quality of Life at a 10-Year Follow-Up of Children Born Preterm with Post-Hemorrhagic Ventricular Dilatation: A Cohort Study. Neonatology (IF 2.5) Pub Date : 2023-09-07 Ayeesha Rela,Sally Jary,Cathy Williams,Pete Blair,William Hollingworth,Ian Pople,Andrew Whitelaw,Karen Luyt,David Edward Odd
BACKGROUND Post-haemorrhagic ventricular dilatation (PHVD) is commonly seen in extremely preterm babies, carries significant morbidity, and may cause neonatal mortality. There is a lack of literature on the subsequent health-related quality of life (HRQoL) in childhood. The aim of this work was to assess the quality of life of preterm babies after PHVD at 10 years of age using two validated questionnaires
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Trends in Preterm Body Composition and Neurodevelopmental Outcomes after Discharge. Neonatology (IF 2.5) Pub Date : 2023-09-06 Laura E Lach,Katherine E Chetta,Mathew J Gregoski,Lakshmi D Katikaneni
INTRODUCTION Body composition, specifically fat-free mass (FFM), of preterm infants is associated with improved neurodevelopmental outcomes. Little is known about body composition of preterm infants after discharge. Preterm body composition was measured by air displacement plethysmography (ADP) at two time points, inpatient (35-40 weeks postmenstrual age [PMA]) and outpatient (48-58 weeks PMA), with
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Effects of Catecholamines on Blood Flow in Preterm Infants: A Subanalysis of PICC-MBF Trial. Neonatology (IF 2.5) Pub Date : 2023-09-01 Akio Ishiguro,Kazuhiko Kabe
INTRODUCTION This study evaluated the correlation between skin blood flow and systemic blood flow and whether skin blood flow can determine the circulatory effects of dopamine and dobutamine on blood flow in very low birth weight (VLBW) infants. METHODS This study was a subanalysis of the PICC-MBF randomized controlled trial. The correlation between skin blood flow and echocardiographic findings was
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Microstructural Brain Development and Neurodevelopmental Outcome of Very Preterm Infants of Mothers with Gestational Diabetes Mellitus. Neonatology (IF 2.5) Pub Date : 2023-08-29 Maria Sappler,Nina Volleritsch,Marlene Hammerl,Yasmin Pellkofer,Elke Griesmaier,Elke Ruth Gizewski,Susanne Kaser,Ursula Kiechl-Kohlendorfer,Vera Neubauer
INTRODUCTION There are data linking gestational diabetes mellitus (GDM) with adverse neurodevelopmental outcome in the offspring. We investigated the effect of GDM on microstructural brain development and neurodevelopmental outcome of very preterm infants. MATERIALS AND METHODS Preterm infants <32 gestational weeks of mothers with GDM obtained cerebral magnetic resonance imaging (MRI) including diffusion-tensor
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The Effect of Postnatal Cytomegalovirus Infection on (Micro)structural Cerebral Development in Very Preterm Infants at Term-Equivalent Age. Neonatology (IF 2.5) Pub Date : 2023-08-25 Yasmin Pellkofer,Marlene Hammerl,Elke Griesmaier,Maria Sappler,Elke Ruth Gizewski,Ursula Kiechl-Kohlendorfer,Vera Neubauer
INTRODUCTION There are some data indicating a negative impact of postnatal cytomegalovirus (CMV) infection on long-term neurodevelopmental outcome of preterm infants. So far, there is only little knowledge about a cerebral imaging correlate of these neurodevelopmental alterations induced by postnatal CMV infection in preterm infants. The aim of the current study was to investigate the effect of postnatal
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Point-of-Care Ultrasound versus Chest X-Ray for Determining Lung Expansion Based on Rib Count in High-Frequency Oscillatory Ventilation. Neonatology (IF 2.5) Pub Date : 2023-08-25 Ozlem Sahin,Derya Colak,Sevinc Tasar,Funda Yavanoglu Atay,Omer Guran,Ilke Mungan Akin
INTRODUCTION Chest X-ray (CXR) is the most prevalent method for evaluating lung expansion in high-frequency oscillatory ventilation (HFOV). The purpose of this study was to compare the accuracy of chest radiography with point-of-care ultrasound (POCUS) in determining lung expansion. METHODS This prospective study included newborns who required HFOV and were monitored in a neonatal intensive care unit
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Morbidity and Mortality of Very-Low-Birthweight Twin Infants according to Their Sex and the Sex of the Co-Twin: A Retrospective Cohort Study. Neonatology (IF 2.5) Pub Date : 2023-08-24 Fermin García-Muñoz Rodrigo,Lourdes Urquía Martí,Carlos Zozaya Nieto,Gloria Galán Henríquez,Desiderio Reyes Suárez,Alejandro Avila-Alvarez,Josep Figueras Aloy,Maximo Vento
INTRODUCTION The concept of male disadvantage regarding the prognosis of premature newborns was introduced more than half a century ago, and it has been corroborated over time. However, the influence of the sex of one twin on the outcomes of the other has yielded contradictory results. OBJECTIVE The aim of the study was to determine if, in twin pregnancies of VLBW infants, the outcomes of one twin
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Echocardiographic Assessment of Pulmonary Arterial Hypertension Following Inhaled Nitric Oxide in Infants with Severe Bronchopulmonary Dysplasia. Neonatology (IF 2.5) Pub Date : 2023-08-11 María V Fraga,Kevin C Dysart,Jason Z Stoller,Matthew Huber,Anysia Fedec,Laura Mercer-Rosa,Haresh Kirpalani
OBJECTIVES Inhaled nitric oxide (iNO) is an effective pulmonary vasodilator. However, the efficacy of iNO in former premature infants with established bronchopulmonary dysplasia (BPD) has not been studied. This study aimed to determine the efficacy of iNO in reducing pulmonary artery pressure in infants with severe BPD as measured by echocardiography. STUDY DESIGN Prospective, observational study enrolling
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Association of Maternal Cigarette Smoking with Neonatal Death: A Population-Based Cohort Study. Neonatology (IF 2.5) Pub Date : 2023-08-11 Ran Wang,Xia Han,Bingxue Zhu,Ming Ye,Qiqi Shi
INTRODUCTION Maternal pregnancy smoking has adverse perinatal outcomes and the relationship between maternal smoking and neonatal death has not been fully elucidated. We aimed to examine the risk of neonatal death in relation to maternal smoking and to quantify potential mediators of these associations. METHODS We did a population-based cohort study using Period Linked Birth-Infant Death data from
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Clinical Prediction Models and Predictors for Death or Adverse Neurodevelopmental Outcome in Term Newborns with Hypoxic-Ischemic Encephalopathy: A Systematic Review of the Literature. Neonatology (IF 2.5) Pub Date : 2023-08-03 Juliette F Langeslag,Kevin Berendse,Joost G Daams,Wes Onland,Mariska M G Leeflang,Anton H van Kaam,Timo R de Haan
BACKGROUND Although many predictive parameters have been studied, an internationally accepted, validated predictive model to predict the clinical outcome of asphyxiated infants suffering from hypoxic-ischemic encephalopathy is currently lacking. The aim of this study was to identify, appraise and summarize available clinical prediction models, and provide an overview of all investigated predictors
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Heart Rate Changes following Facemask Placement in Infants Born at ≥32+0 Weeks of Gestation. Neonatology (IF 2.5) Pub Date : 2023-08-02 Shiraz Badurdeen,Elisa Brooijmans,Douglas A Blank,Kristel Leontina Anne Marie Kuypers,Arjan B Te Pas,Calum Roberts,Graeme R Polglase,Stuart B Hooper,Peter G Davis
INTRODUCTION Recent reports have raised concerns of cardiorespiratory deterioration in some infants receiving respiratory support at birth. We aimed to independently determine whether respiratory support with a facemask is associated with a decrease in heart rate (HR) in some late-preterm and term infants. METHODS Secondary analysis of data from infants born at ≥32+0 weeks of gestation at 2 perinatal
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Application of Artificial Intelligence in the Early Detection of Retinopathy of Prematurity: Review of the Literature. Neonatology (IF 2.5) Pub Date : 2023-07-25 Shivani Shah,Elizabeth Slaney,Erik VerHage,Jinghua Chen,Raquel Dias,Bishoy Abdelmalik,Alex Weaver,Josef Neu
Retinopathy of prematurity (ROP) is a potentially blinding disease in premature neonates that requires a skilled workforce for diagnosis, monitoring, and treatment. Artificial intelligence is a valuable tool that clinicians employ to reduce the screening burden on ophthalmologists and neonatologists and improve the detection of treatment-requiring ROP. Neural networks such as convolutional neural networks
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A Meta-Analysis of Neurodevelopmental Outcomes following Intravitreal Bevacizumab for the Treatment of Retinopathy of Prematurity. Neonatology (IF 2.5) Pub Date : 2023-07-24 Abed A Baiad,Imaan Z Kherani,Marko M Popovic,Glen Katsnelson,Rajeev H Muni,Kamiar Mireskandari,Nasrin N Tehrani,Tianwei Ellen Zhou,Peter J Kertes
BACKGROUND Retinopathy of prematurity (ROP) is the most common cause of preventable blindness in preterm infants. First-line treatments include intravitreal bevacizumab (IVB) or laser photocoagulation (LPC). OBJECTIVES The aim of the study was to evaluate neurodevelopmental safety of IVB compared to LPC for ROP. METHODS MEDLINE, Embase, and Cochrane library were searched up to September 2022. Studies
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Neonatal Thrombocytopenia as a Presenting Finding in de novo Pyruvate Kinase Deficiency. Neonatology (IF 2.5) Pub Date : 2023-07-20 Brian M Dulmovits,K Taylor Wild,John Flibotte,Michele P Lambert,Janet Kwiatkowski,Christopher S Thom
Thrombocytopenia is a common laboratory abnormality encountered in critically ill neonates. The broad differential for thrombocytopenia, and its association with potentially severe neonatal pathology, often presents a diagnostic dilemma prompting extensive evaluation. Hemolysis due to red cell enzymopathies is a rare cause of neonatal thrombocytopenia that is typically brief and self-limiting. Here
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Learning-Based Longitudinal Prediction Models for Mortality Risk in Very-Low-Birth-Weight Infants: A Nationwide Cohort Study. Neonatology (IF 2.5) Pub Date : 2023-07-17 Jae Yoon Na,Donggoo Jung,Jong Ho Cha,Daehyun Kim,Joonhyuk Son,Jae Kyoon Hwang,Tae Hyun Kim,Hyun-Kyung Park
INTRODUCTION Prediction models assessing the mortality of very-low-birth-weight (VLBW) infants were confined to models using only pre- and perinatal variables. We aimed to construct a prediction model comprising multifactorial clinical events with data obtainable at various time points. METHODS We included 15,790 (including 2,045 in-hospital deaths) VLBW infants born between 2013 and 2020 who were
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Fluctuations in Oxygen Saturation during Synchronized Nasal Intermittent Positive Pressure Ventilation and Nasal High-Frequency Oscillatory Ventilation in Very Low Birth Weight Infants: A Randomized Crossover Trial. Neonatology (IF 2.5) Pub Date : 2023-06-30 Svilen Atanasov,Constanze Dippel,Dupleix Takoulegha,Anita Windhorst,Rahel Schuler,Claas Strodthoff,Inéz Frerichs,Jens Dreyhaupt,Markus Waitz,Keywan Sohrabi,Harald Ehrhardt
BACKGROUND Very low birth weight (VLBW) infants on noninvasive ventilation (NIV) experience frequent fluctuations in oxygen saturation (SpO2) that are associated with an increased risk for mortality and severe morbidities. METHODS In this randomized crossover trial, VLBW infants (n = 22) born 22+3 to 28+0 weeks on NIV with supplemental oxygen were allocated on two consecutive days in random order to
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Symptomatic Postnatal Cytomegalovirus Infection in Less than 32-Week Preterm Infants: 13-Year Retrospective Multicenter Case-Control Study. Neonatology (IF 2.5) Pub Date : 2023-06-30 Sarah Jane Corpuz Tapawan,Barbara Bajuk,Ju Lee Oei,Pamela Palasanthiran,
INTRODUCTION Reports on the influence of postnatal cytomegalovirus (pCMV) infection in neonatal outcomes of preterm babies vary while guidance on management including screening is lacking. We aim to determine the association between symptomatic pCMV infection and chronic lung disease (CLD) and mortality in preterm infants born less than 32 weeks gestation. METHODS We used data from the Neonatal Intensive
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Heart Rate Characteristics Monitoring for Late-Onset Sepsis in Preterm Infants: A Systematic Review. Neonatology (IF 2.5) Pub Date : 2023-06-28 Hugo J Koppens,W Onland,Douwe H Visser,Nerissa P Denswil,Anton H van Kaam,Claire A Lutterman
BACKGROUND Early diagnosis of late-onset sepsis (LOS) and necrotizing enterocolitis (NEC) by monitoring heart rate characteristics (HRC) of preterm infants might reduce the risk of death and morbidities. We aimed to systematically assess the effects of HRC monitoring on death, LOS, and NEC. METHODS A systematic search was performed in MEDLINE, Embase, Cochrane Library, and Web of Science. RESULTS Fifteen
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Prognosticating the Outcomes of HIE with Certainty: Mission Impossible? - Commentary on "Clinical Prediction Models and Predictors for Death or Adverse Neurodevelopmental Outcome in Term Newborns with Hypoxic Ischemic Encephalopathy: A Systematic Review of the Literature". Neonatology (IF 2.5) Pub Date : 2023-06-28 Nicole M Anderson,Matthew Hicks,Po-Yin Cheung
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Deep Medullary Vein Thrombosis in Newborns: A Systematic Literature Review. Neonatology (IF 2.5) Pub Date : 2023-06-28 Jacopo Norberto Pin,Letizia Leonardi,Margherita Nosadini,Maria Federica Pelizza,Luca Capato,Luca Piretti,Maria Elena Cavicchiolo,Paolo Simioni,Eugenio Baraldi,Giorgio Perilongo,Matteo Luciani,Stefano Sartori
BACKGROUND Deep medullary vein (DMV) thrombosis is a rare cause of brain damage in both preterm and full-term neonates. In this study, we aimed to collect data on clinical and radiological presentation, treatment, and outcome of neonatal DMV thrombosis. METHODS Systematic literature review on neonatal DMV thrombosis was carried out in PubMed, ClinicalTrial.gov, Scopus, and Web of Science up to December
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The Association of Dexamethasone and Hydrocortisone with Cerebellar Growth in Premature Infants. Neonatology (IF 2.5) Pub Date : 2023-06-28 Laura A Warmerdam,Gerda van Wezel-Meijler,Linda S de Vries,Floris Groenendaal,Sylke J Steggerda
OBJECTIVES Corticosteroids are used to prevent or treat lung disease of prematurity. While neurological side effects have been reported, detailed effects on cerebellar growth are unknown. This study aimed to compare cerebellar growth in premature infants who received dexamethasone or hydrocortisone to premature infants who did not receive postnatal corticosteroids. STUDY DESIGN Retrospective case-control
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Effect of Early Erythropoietin on Retinopathy of Prematurity: A Stratified Meta-Analysis. Neonatology (IF 2.5) Pub Date : 2023-06-27 Hendrik S Fischer,Nora J Reibel,Christoph Bührer,Christof Dame
BACKGROUND Recombinant human erythropoietin (rhEPO) lost its role in minimizing red blood cell transfusion in very preterm infants after it had been associated with severe retinopathy of prematurity (ROP). Previous systematic reviews did not stratify ROP by gestation and birth weight (BW). OBJECTIVES The aim of this study was to investigate the effect of early prophylactic rhEPO on ROP in a stratified
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How to Control Exposure to Fifth-Generation Radiofrequencies in Preterm Newborns in Incubator. Neonatology (IF 2.5) Pub Date : 2023-06-21 Karen Chardon,Stéphane Delanaud,Pierre Tourneux,Erwan Stephan Blanchard
Infant and family centered development care reduces infant distress and supports the parent and infant's individual abilities. However, a new environmental factor is daily encountered: the radiofrequency electromagnetic fields (RF EMFs) with the most recent fifth-generation (5G) technology. Currently, the effects of RF EMF during development are discussed in animal models. The neonatal intensive care
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Procalcitonin for Detecting Culture-Positive Sepsis in Neonates: A Prospective, Multicenter Study. Neonatology (IF 2.5) Pub Date : 2023-06-19 Suman Chaurasia,Pratima Anand,Akash Sharma,Sushma Nangia,Adhi Sivam,Kajal Jain,Rajni Gaind,Ravinder Kaur,Apurba S Sastry,Arti Kapil,Meenakshi Bhatt,Meetu Salhan,Ajay Dudeja,Nishad Plakkal,Ankit Verma,Manisha Jain,Sonal Saxena,Sarita Mohapatra,Archana Kashyap,Srishti Goel,Sindhu Sivanandan,Sugandha Arya,Savita Saini,Tapish Pande,Sumita Saluja,Monica Sharma,Sreenivas Vishnubhatla,Harish Chellani,M Jeeva
INTRODUCTION It is unclear if serum procalcitonin (PCT) estimated at sepsis suspicion can help detect culture-positive sepsis in neonates. We evaluated the diagnostic performance of PCT in culture-positive sepsis in neonates. METHODS This was a prospective study (February 2016 to September 2020) conducted in four level-3 units in India. We enrolled neonates suspected of sepsis in the first 28 days
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Maternal, Perinatal, and Postnatal Predisposing Factors of Hearing Loss in Full-Term Children: A Matched Case-Control Study. Neonatology (IF 2.5) Pub Date : 2023-06-15 Pei-Chen Tsao,Hung-Chih Lin,Hsiao-Yu Chiu,Yu-Chia Chang
INTRODUCTION Studies on risk factors for childhood hearing loss (HL) are usually based on questionnaires or small sample sizes. We conducted a nationwide population-based case-control study to comprehensively analyze the maternal, perinatal, and postnatal risk factors for HL in full-term children. METHODS We retrieved data from three nationwide databases related to maternal characteristics, perinatal
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Melatonin Alters Innate Immune Function in Infants with Neonatal Encephalopathy. Neonatology (IF 2.5) Pub Date : 2023-06-15 Saima Aslam,Mary O'Dea,Lynne A Kelly,Amanda O'Neill,Ellen McKenna,Tim Hurley,Aoife Branagan,David O'Driscoll,Caoimhe Normile,Shahid Saleemi,Deirdre Sweetman,Claudine Vavasseur,John Murphy,Veronica Donoghue,William Watson,Eleanor J Molloy
INTRODUCTION Melatonin has been suggested an adjunctive therapy in neonatal encephalopathy (NE). Melatonin reduces oxidative stress and neutrophil activation; however, the immunological effects in NE have not been studied. METHODS Infants with NE and neonatal controls were prospectively recruited. Whole blood was sampled in the first week of life. Following endotoxin and or melatonin treatment, diurnal
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Assessment of Comfort during Less Invasive Surfactant Administration in Very Preterm Infants: A Multicenter Study. Neonatology (IF 2.5) Pub Date : 2023-06-13 Karin Pichler,Benjamin Kuehne,Janneke Dekker,Sophie Stummer,Vito Giordano,Angelika Berger,Angela Kribs,Katrin Klebermass-Schrehof
INTRODUCTION This study was set up to investigate if and to what extent non-pharmacological analgesia is able to provide comfort to very preterm infants (VPI) during less invasive surfactant administration (LISA). METHODS This was a prospective non-randomized multicenter observational study performed in level IV NICUs. Inborn VPI with a gestational age between 220/7 and 316/7 weeks, signs of respiratory
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Combining MRI and Spectral EEG for Assessment of Neurocognitive Outcomes in Preterm Infants. Neonatology (IF 2.5) Pub Date : 2023-06-08 Tone Nordvik,Andres Server,Cathrine N Espeland,Eva M Schumacher,Pål G Larsson,Are H Pripp,Tom Stiris
INTRODUCTION Predicting impairment in preterm children is challenging. Our aim is to explore the association between MRI at term-equivalent age (TEA) and neurocognitive outcomes in late childhood and to assess whether the addition of EEG improves prognostication. METHODS This prospective observational study included forty infants with gestational age 24 + 0-30 + 6. Children were monitored with multichannel
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Age-Related Prevalence of Open Ductus Arteriosus in Full-Term Newborns. Neonatology (IF 2.5) Pub Date : 2023-06-07 Anton Friis Mariager,Alberte Hammeken,Mikkel Malham,Anna Axelsson Raja,Anna Sellmer,Signe Levring Skjellerup,Raheel Altaf Raja,Johan Navne,Anne-Sophie Sillesen,Niels Vejlstrup,Henning Bundgaard,Kasper Karmark Iversen,Ester Garne,Dorthe Lisbeth Jeppesen
BACKGROUND The ductus arteriosus is part of the fetal circulation. Normally, the vessel closes during the cardiac transition. Delayed closure is associated with complications. The aim of this study was to evaluate the age-related prevalence of open ductus arteriosus in full-term neonates. METHODS Echocardiograms were collected in the population study, the Copenhagen Baby Heart Study. The present study
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Analysis of Fractional Cerebral Oxygen Extraction in Preterm Infants during the Kangaroo Care. Neonatology (IF 2.5) Pub Date : 2023-06-07 Álvaro Solaz-García,Ángel Sánchez-Illana,Inmaculada Lara-Cantón,Raimunda Montejano-Lozoya,Ana Gimeno-Navarro,Alejandro Pinilla-González,Laura Torrejón-Rodríguez,Maximo Vento,Pilar Sáenz-González
INTRODUCTION We aimed to investigate the cerebral fractional tissue oxygen extraction (FtOE) during kangaroo care (KC) in premature infants and compare cardiorespiratory stability and hypoxic or bradycardic events between KC and incubator care. METHODS A single-center prospective observational study was carried out at the NICU of a level 3 perinatal center. Preterm infants <32 weeks gestational age
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Characteristics of Meningococcal Invasive Disease in Neonates and Virulence of the Corresponding Isolates. Neonatology (IF 2.5) Pub Date : 2023-06-06 Melissa Beggaz,Tamazoust Guiddir,Eva Hong,Ala-Eddine Deghmane,Muhamed-Kheir Taha
BACKGROUND The highest incidence of invasive meningococcal disease (IMD) is observed in infants. However, its prevalence in neonates (≤28 days of age) and the characteristics of the corresponding isolates are less described. This report aimed to analyze meningococcal isolates from neonates. METHODS We first screened the database of the national reference center for meningococci in France for confirmed
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Sedation Prior to Intubation at Birth in Infants with Congenital Diaphragmatic Hernia: An International Survey on Current Practices. Neonatology (IF 2.5) Pub Date : 2023-06-06 Emily J J Horn-Oudshoorn,Alisa M Blekherov,Gerbrich E van den Bosch,Sinno H P Simons,Ronny Knol,Arjan Te Pas,Irwin K M Reiss,Philip L J DeKoninck
INTRODUCTION Infants with congenital diaphragmatic hernia (CDH) are commonly intubated immediately after birth. Consensus on whether to provide sedation prior to intubation in the delivery room is lacking, although avoidance of stress is especially important in this population with high risk of pulmonary hypertension. We aimed at obtaining an overview of local pharmacological interventions and at providing
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Indomethacin Prophylaxis Is Associated with Reduced Risk of Intraventricular Hemorrhage in Extremely Preterm Infants Born in the Context of Amniotic Infection Syndrome. Neonatology (IF 2.5) Pub Date : 2023-06-02 Kathrin Hanke,Ingmar Fortmann,Alexander Humberg,Kirstin Faust,Angela Kribs,Sebastian Prager,Ursula Felderhoff-Müser,Marcus Krüger,Matthias Heckmann,Anja Jäger,Oliver Andres,Juliane Spiegler,Christoph Härtel,Egbert Herting,Wolfgang Göpel
BACKGROUND Amniotic infection syndrome (AIS) with perinatal inflammation may increase the susceptibility to intraventricular hemorrhage (IVH) in preterm infants. Given its anti-inflammatory and ductus arteriosus constricting capacities, we hypothesized that prophylactic administration of indomethacin reduces the incidence, severity, and consequences of IVH in the context of perinatal inflammation.
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A Nomogram for Predicting Extubation Failure in Preterm Infants with Gestational Age Less than 29 Weeks. Neonatology (IF 2.5) Pub Date : 2023-05-31 Feifan Chen,Yanru Chen,Yumin Wu,Xingwang Zhu,Yuan Shi
INTRODUCTION How to avoid reintubations in prematurity remains a hard nut. This study aimed to develop and validate a nomogram for predicting extubation failure in preterm infants who received different modes of noninvasive ventilation as post-extubation support. METHODS This was a secondary analysis of pre-existing data from a large multicenter RCT combined with a multicenter retrospective investigation
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From Exclusion to Glass Ceiling: A History of Women in Neonatal Medicine. Neonatology (IF 2.5) Pub Date : 2023-05-31 Michael Obladen
The 21st century's medicine is predominantly female: two thirds of medical students now are women. In 375 BCE, Plato argued for equal education for male and female professions, explicitly physicians. In Greece and Rome, tombstones testify for patients' gratitude to women physicians. Christianization opened an era of female subordination. When universities established faculties of medicine during the
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Graphic Intelligent Diagnosis of Hypoxic-Ischemic Encephalopathy Using MRI-Based Deep Learning Model. Neonatology (IF 2.5) Pub Date : 2023-05-25 Tian Tian,Tongjia Gan,Jun Chen,Jun Lu,Guiling Zhang,Yiran Zhou,Jia Li,Haoyue Shao,Yufei Liu,Hongquan Zhu,Di Wu,Chengcheng Jiang,Jianbo Shao,Jingjing Shi,Wenzhong Yang,Wenzhen Zhu
INTRODUCTION Heterogeneous MRI manifestations restrict the efficiency and consistency of neuroradiologists in diagnosing hypoxic-ischemic encephalopathy (HIE) due to complex injury patterns. This study aimed to develop and validate an intelligent HIE identification model (termed as DLCRN, deep learning clinical-radiomics nomogram) based on conventional structural MRI and clinical characteristics. METHODS
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Ending Preventable Neonatal Deaths: Multicountry Evidence to Inform Accelerated Progress to the Sustainable Development Goal by 2030. Neonatology (IF 2.5) Pub Date : 2023-05-16 Joy E Lawn,Zulfiqar A Bhutta,Chinyere Ezeaka,Ola Saugstad
INTRODUCTION The Sustainable Development Goal (SDG) 3.2 aims for every country to reach a neonatal mortality rate (NMR) of ≤12/1,000 live births by 2030. More than 60 countries are off track, and 2.3 million newborns still die each year. Urgent action is needed, but varies by context, notably mortality level. METHODS We applied a five-phase NMR transition model based on national analyses for 195 UN
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Cerebral Oxygenation during Neonatal Intubation with Nasal High Flow: A Sub-Study of the SHINE Randomized Trial. Neonatology (IF 2.5) Pub Date : 2023-05-10 Ellyn Van Der Veeken,Brett James Manley,Louise Owen,Omar Kamlin,Calum Roberts,Sophie Newman,Kate Francis,Susan Donath,Peter Davis,Rocco Cuzzilla,Kate Alison Hodgson
INTRODUCTION Nasal high flow (nHF) improves the likelihood of successful neonatal intubation on the first attempt without physiological instability. The effect of nHF on cerebral oxygenation is unknown. The aim of this study was to compare cerebral oxygenation during endotracheal intubation in neonates receiving nHF and those receiving standard care. METHODS A sub-study of a multicentre randomized
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A Narrative Review of the Rationale for Conducting Neonatal Emergency Studies with a Waived or Deferred Consent Approach. Neonatology (IF 2.5) Pub Date : 2023-05-09 Anup Katheria,Georg M Schmölzer,Annie Janvier,Vishal Kapadia,Ola D Saugstad,Maximo Vento,Alla Kushnir,Mark Tracy,Wade Rich,Ju Lee Oei
Emergency research studies are high-stakes studies that are usually performed on the sickest patients, where many patients or guardians have no opportunity to provide full informed consent prior to participation. Many emergency studies self-select healthier patients who can be informed ahead of time about the study process. Unfortunately, results from such participants may not be informative for the