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Immunohistochemical Expression of Lymphatic Endothelial Markers in Blue Rubber Bleb Nevus Syndrome Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2024-03-21 Andrea C. Bakker, Steven J. Fishman, Marilyn G. Liang, Alyaa Al-Ibraheemi, Harry P. Kozakewich, John B. Mulliken, Jonathan C. Slack
Introduction:Blue rubber bleb nevus syndrome (BRBNS) is an uncommon vascular anomaly characterized by multifocal cutaneous, visceral, and other soft tissue or solid organ venous malformations. We observed that BRBNS lesions express immunohistochemical markers of lymphatic differentiation.Methods:BRBNS histopathologic specimens assessed at our institution during the past 27 years were reviewed. Slides
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Response to Letter to the Editor: “Remote Placental Sign-Out: What Digital Pathology Can Offer for Pediatric Pathologists” Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2024-03-12 Stefano Marletta, Liron Pantanowitz, Nicola Santonicco, Alessandro Caputo, Emma Bragantini, Matteo Brunelli, Ilaria Girolami, Albino Eccher
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Remote Placental Sign-Out: What Digital Pathology Can Offer for Pediatric Pathologists Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2024-03-12 Casey P. Schukow, Jacqueline K. Macknis
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Interfollicular Classic Hodgkin Lymphoma: Report of a Case and a Brief Review of Literature Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2024-03-12 Kristina Brannock, Samir B. Kahwash
Interfollicular Hodgkin lymphoma (IHL) has been rarely reported in the literature and is recognized by the WHO Classification as a morphologic pattern sometimes seen in mixed cellularity classic Hodgkin lymphoma (CHL). The changes may be subtle due to preservation of architecture. We report a case of a 9-year-old male with IHL showing preserved follicular architecture but with the presence of interfollicular
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Childhood and Adolescent Relapsed/Refractory Aggressive B-Cell Lymphomas With t(8;14) and BCL2 Expression, Burkitt Lymphoma Versus Diffuse Large B-Cell Lymphoma: A Diagnostic Challenge Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2024-03-12 Fouad El Dana, Sofia Alexandra Garces Narvaez, Nader K. El-Mallawany, Jennifer E. Agrusa, ZoAnn E. Dreyer, Andrea N. Marcogliese, Mohamed Tarek Elghetany, Jyotinder N. Punia, Chi Young Ok, Keyur P. Patel, Dolores H. Lopez-Terrada, Kevin E. Fisher, Choladda V. Curry
We present 2 diagnostically challenging cases of pediatric/adolescent relapsed/refractory aggressive mature B-cell non-Hodgkin lymphoma (B-NHL) within the spectrum of Burkitt lymphoma and diffuse large B-cell lymphoma and illustrate the different therapeutic regimens that are employed for pediatric and adult cancer centers. Both cases displayed varying-sized lymphoma cells with occasional single prominent
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Pediatric Rectosigmoid Atypical Juvenile Polyps Presenting With Rectal Prolapse and Acute Bleeding: A Case Report and a Comprehensive Literature Review Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2024-03-12 Javier Arredondo Montero, Elena Carracedo Vega, Socorro Razquin Lizarraga, Mónica Bronte Anaut, Sara Hernández-Martín, Gina de Lima Piña, Rosa Guarch Troyas
Rectosigmoid solitary juvenile polyps are benign lesions, relatively frequent in childhood. The clinical debut of a pediatric polyp with bleeding is relatively frequent, but there are very few reports of rectal prolapse of polyps. We present the case of a 7-year-old female patient with no previous history who presented with rectal prolapse of a polyp with acute bleeding. An urgent endoscopic examination
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Founders of Pediatric Pathology: Dr. Ron Jaffe (1943–2022) – An Appreciation Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2024-02-24 Laura S. Finn, Jennifer Picarsic, A. S. Knisely
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A Pediatric Primary Cardiac Spindle Cell Neoplasm With a Rare PDGFRA::USP8 Gene Fusion: A Case Report Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2024-02-24 Ariel Gershon, Anita Nagy, Gino R. Somers, Shi-Joon Yoo, Furqan Shaikh, Osami Honjo, Robert Siddaway, Haiying Chen
We report a case of a primary cardiac spindle cell neoplasm with concerning histological features and a rare PDGFRA::USP8 gene fusion in a 3 year old boy. The patient presented with a large cardiac mass predominantly in the right ventricle, originating from the ventricular septum. The mass was resected with grossly negative margins. Pathology revealed an unclassified spindle cell neoplasm with a PDGFRA::USP8
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Perfusion Pressure and the Histology of Brain Death: A Unique Case in an Infant Maintained on Life Support Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2024-01-31 Meagan Chambers, Gail Deutsch
Brain death is a not uncommon phenomena in the adult and pediatric population. Most cases are removed from life support soon after brain death is declared. Less commonly, systemic perfusion is maintained by life support for some time after neurologic function stops. These cases present uncommon opportunities to explore the histology of necrosis and autolysis in the context of global hypoxic ischemic
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Nephrotic Syndrome in a Child With NPHS2 Mutation Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2024-01-31 Ross Tollaksen, Randall D. Craver, Ihor V. Yosypiv
Steroid resistant nephrotic syndrome (SRNS) accounts for 30% of all cases of nephrotic syndrome (NS) in children and frequently leads to end stage kidney disease (ESKD). About 30% of children with SRNS demonstrate causative mutations in podocyte- associated genes. Early identification of genetic forms of SRNS is critical to avoid potentially harmful immunosuppressive therapy. A 2-year-old male patient
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Granulomas in Pediatric Liver Biopsies: Single Center Experience Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2024-01-15 Muhammad Shaheen, Guang-Sheng Lei, Ryan F. Relich, Chaowapong Jarasvaraparn, Kyla M. Tolliver, Jean P. Molleston, Iván A. González
Background:Granulomas in pediatric liver biopsies (GPLB) are rare with the largest pediatric cohort reported over 25 years ago.Methods:Single-center retrospective study of GPLB.Results:Seventeen liver biopsies from 16 patients with granulomas were identified (9 boys, 56%) with a median age of 13 years (range: 1–18) for which the most common indication was the presence of a nodule/mass (47%). Significant
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First Reported Histologically and Molecularly Confirmed Bilateral High-Grade Serous Ovarian Adenocarcinoma Metastasized to Placental Decidua of the Membranes Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2024-01-15 Salma El Emrani, Linda S. Nooij, Chiara C. M. M. Lap, Lotte E. van der Meeren
A 43-year-old female presented with blood loss and persistent abdominal pain at 14 weeks of gestation. Ultrasound examination and subsequent magnetic resonance imaging (MRI) revealed bilateral multicystic uterine adnexa. Exploratory laparotomy was performed at 17 weeks of gestation and bilateral serous ovarian adenocarcinoma FIGO stage IIIC was diagnosed. Complete cytoreductive surgery (CRS) was not
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Hidden Coronary Artery Ostium and Sudden Death Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2024-01-15 Luzern Tan, Karen Heath, Roger W. Byard
A 1-week-old girl died suddenly and unexpectedly. At autopsy the major finding was of a right dominant coronary artery circulation with an inapparent left coronary artery ostium. After careful examination, an anomalous origin of the left coronary artery was found with the ostium located in the non-coronary cusp immediately adjacent to the commissure of the non- and left coronary cusps. The ostium was
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Gastrointestinal Tract Granular Cell Tumor in the Pediatric Population: A Multicenter Experience Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2024-01-05 Muhammad Shaheen, Benjamin J. Wilkins, Archana Shenoy, Kathleen Byrnes, Xiaoyi Tina Zhang, Iván A. González
Background:Pediatric granular cell tumors (GCT) involving the gastrointestinal tract (GIT) are rare with limited case report/series reported to date.Methods:Multicenter retrospective study of pediatric GIT GCT.Results:A total of 10 cases were included in the study with a median age of 13.5 years (range: 7-18 years) and were predominantly female patients (60%). In half of the patients no significant
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Mullerian Serous Cystadenoma Occurring in the Scrotum Post-Orchidopexy: A Rarely Reported Yet Distinctive Entity Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2024-01-05 Benjamin Champion, Tiffany Foo, Colin Kikiros, Adrian Charles
Serous cystadenoma is a rare lesion in the para-testicular tissue, with even rarer reports of this entity occurring in the scrotum post-orchidopexy. We present such an occurrence, adding support for its existence as a distinct entity.
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How Many Tests Does It Take to Diagnose a Triple-Hit B-Lymphoblastic Lymphoma? (Hint, It's A Lot). Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-11-30 Marie Das,Karen D Tsuchiya,Sandra D Bohling,Billy Davis,Samuel Hwang,Rebecca A Gardner,Karen M Chisholm
B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) is a precursor B-cell neoplasm that often harbors specific cytogenetic/molecular abnormalities with distinctive clinical, phenotypic, and prognostic characteristics. Subcategorization of B-ALL/LBL therefore requires extensive cytogenetic and/or molecular testing to determine the appropriate classification and therapeutic interventions for these patients
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Maud Menten: Pioneering Pediatric-Perinatal Pathologist, Clinician-Scientist, and "the Most Wonderful Human Being in the World". Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-11-25 James R Wright
Maud Menten was born and raised in remote regions of Canada. She obtained her MB/MD at the University of Toronto (1907/1911) and her PhD in biochemistry at the University of Chicago (1916). From 1907 to 1916, she trained at the Rockefeller Institute for Medical Research, the New York Infirmary for Women and Children, Western Reserve University in Cleveland, the Berlin Municipal Hospital in Germany
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Prenatal Coffin-Siris Syndrome: Expanding the Phenotypic and Genotypic Spectrum of the Disease. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-11-19 Sini Keskinen,Teija Paakkola,Mirjami Mattila,Marja Hietala,Hannele Koillinen,Jukka Laine,Maria K Haanpää
Coffin-Siris syndrome is an autosomal dominant disorder with neurological, cardiovascular, and gastrointestinal symptoms. Patients with Coffin-Siris syndrome typically have variable degree of developmental delay or intellectual disability, muscular hypotonia, dysmorphic facial features, sparse scalp hair, but otherwise hirsutism and fifth digit nail or distal phalanx hypoplasia or aplasia. Coffin-Siris
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Addressing Chatbots as Artificial Intelligence Aids in Pediatric Pathology. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-11-19 Casey Schukow,Van-Hung Nguyen
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A Review of Selected Dental Anomalies With Histologic Features in the Pediatric Patient. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-11-14 Kathleen M Schultz,Carla R Penner
Unique dental conditions in children include odontogenic cysts and tumors, hereditary dental diseases, developmental anomalies, and lesions associated with the eruption of the primary or permanent teeth. Many of these conditions have long lasting effects on the adult dentition in terms of affecting esthetics, function, and overall quality of life. Inherited dental syndromes affect the dental hard tissues
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Manual and Semi-Automated Measurement and Calculation of Osteosarcoma Treatment Effect Using Whole Slide Image and Qupath. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-11-09 Mai He,Bofan He,Jinyi Weng,Jerry Q Cheng,Huanying Gu
INTRODUCTION In osteosarcoma, the most significant indicator of prognosis is the histologic changes related to tumor response to preoperative chemotherapy, such as necrosis. We have developed a method to measure the osteosarcoma treatment effect using whole slide image (WSI) with an open-source digital image analytical software Qupath. MATERIALS AND METHODS In Qupath, each osteosarcoma case was treated
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An Unusual Case of Extranodal Marginal Zone Lymphoma Mimicking Abdominal Cocoon Syndrome in an Adolescent Patient. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-10-30 Timothy J D Ohlsen,Ryan J Morse,Hira Ahmad,Maria Cristina Pacheco,Katherine E Debiec,Sandra D Bohling
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is an indolent non-Hodgkin lymphoma rarely seen in pediatric patients. MALT lymphoma most commonly involves the gastrointestinal tract or peri-orbital tissues, potentially as sequela of chronic antigenic stimulation or immune dysregulation. Rare cases of MALT lymphoma arising from the gynecologic tract have been
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CLPB Deficiency Associated Neonatal Cavitating Leukoencephalopathy: A Potential Pathomechanism Underlying Neurologic Disorder. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-10-30 Sihem Darouich,Samia Darouich,Dorsaf Gtari,Houda Bellamine
Caseinolytic peptidase B homolog (CLPB) is a mitochondrial protein which is highly expressed in brain. Its deficiency may be associated with severe neonatal encephalopathy. This report describes a case of fatal neonatal encephalopathy associated with biallelic stop-gain mutation in CLPB (NM_001258392.3:c.1159C>T/p.Arg387*). Neurologic disorder encompasses pre- and post-natal features including polyhydramnios
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Molecular Profiling of a Hepatocellular Neoplasm Not Otherwise Specified (HCN-NOS) Demonstrates Distinct Molecular Features in Hepatoblastoma and HCC-Like Components. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-10-30 Yan Chen Wongworawat,Stephen F Sarabia,Martin Urbicain,Paola Francalanci,Pavel Sumazin,Rita Alaggio,Dolores H López-Terrada
Hepatoblastomas (HB) are embryonal tumors with quiet genomes diagnosed mostly in children under 3 years of age and often cured by surgical resection and chemotherapy. However, a subset of HBs behave aggressively, displaying characteristic histologic features and higher genomic instability. Hepatocellular neoplasm-not otherwise specified (HCN-NOS) is a provisional diagnostic category for tumors exhibiting
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Skeletal Growth Arrest Lines in Fetal Remains: Histopathology and Correlative Placental Pathology. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-10-11 Tsz Wing Chu,Patrick Shannon,Tony Parks
INTRODUCTION Skeletal growth arrest lines (GAL) are transverse lines of metaphyseal radiodensity accompanying episodic severe physiological stress. They are poorly described in fetal remains. MATERIALS AND METHODS We searched our autopsy practice for instances of fetal GAL in post mortem radiology, and correlated them with long bone histology and placental pathology. We describe the appearance, distribution
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Spontaneous Partial Regression of Fetal Lung Interstitial Tumor With A2M::ALK Rearrangement in a Neonate. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-10-11 Alfonso Tan-Garcia,York Tien Lee,Chik Hong Kuick,Shui Yen Soh,Kenneth Tou-En Chang,Khurshid Merchant
The differential diagnosis for neonatal primary lung masses includes developmental anomalies and congenital lung tumors. Fetal lung interstitial tumor (FLIT) is a rare benign mesenchymal lesion which presents either antenatally or within the first 3 months of age. FLIT is a circumscribed solid-cystic mass which histologically resembles the fetal lung during the canalicular stage at 20-24 weeks of gestation
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Expanding the Spectrum of EWSR1::CREM Fusion Tumors: An Unusual Pediatric Intranasal Myxoid Tumor. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-10-11 Shamen Koh,Lavisha S Punjabi,Kenneth Tou En Chang,Neville Wei Yang Teo,Constance Ee Hoon Teo,Shui Yen Soh,Henry Kun Kiaang Tan
EWSR1::CREM gene fusions are increasingly being recognized in a diverse number of soft tissue tumors, including well-defined entities such as angiomatoid fibrous histiocytoma or clear cell sarcoma, and other unclassifiable tumors. As a group, EWSR1::CREM fused tumors often demonstrate primitive spindle or epithelioid cells, myxoid stroma, and a broad immunophenotype. Herein we present an unusual case
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Intrahepatic Cholangiolitis in Cystic Fibrosis (ICCF): An Under-Appreciated Cause of Persistent Cholestasis in Infancy. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-10-06 Anas Bernieh,Kevin Bove,Victor Garcia,Gregory Tiao,Lauren Lazar,Meghana Sathe,Julie Sanchez,Raquel Gonzalez,Ignacio Gonzalez-Gomez
Liver histology in infants with cystic fibrosis (CF) and persistent cholestasis is seldom reported in detail. We extend previous observation of a distinctive intrahepatic cholangiopathy (ICCF) to 3 additional infants homozygous for CFTR pathological variants and a fourth infant with a heterozygous CFTR variant, summarizing our experience in 10 infants with CFTR variants and persistent cholestasis.
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Long-Term Effect of TBX4 Germline Mutation on Pulmonary Clinico-Histopathologic Phenotype. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-10-06 Elizabeth S Doughty,Christian Norvik,Alice Levin,Jenna Bodmer,Karin Tran-Lundmark,Steven H Abman,Csaba Galambos
Tbx4 protein, expressed in mesenchyme of the developing lung, contributes to airway branching and distal lung growth. An association between pediatric onset of pulmonary arterial hypertension (PAH) and genetic variations coding for the T-box transcription factor 4 gene (TBX4) has been increasingly recognized. Tbx4-related PAH onset has a bimodal age distribution, including severe to lethal PAH in newborns
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Clinical and Histological Associations of Chronic Inflammatory Lesions in Preterm Placentas: Uncovering the Hidden Dangers. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-10-06 Gayatri Ravikumar,Victoria Liza
BACKGROUND Chronic placental inflammatory lesions (CPIL) include chronic deciduitis (CD), villitis of unknown etiology (VUE), and chronic chorioamnionitis (CCA). The frequency of these lesions and their relationship with various clinicopathological parameters in preterm birth (PTB) is presented. MATERIAL AND METHODS Preterm placentas from April 2018 to December 2020 were reviewed for presence of CPIL
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Metastatic Lymphomas of the Placenta: A Literature Review With an Illustrative Case. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-09-28 Marvin C Masalunga,Ronell L Basa,Karen B Damian,Jose M Carnate
Lymphoma is the fourth most common tumor to display placental metastasis. This study aimed to report a case of high-grade lymphoma involving the placenta and review the literature on lymphomas metastatic to the placenta. A systematic review was performed following the PRISMA guidelines, using the keywords "lymphoma" AND "placenta." All case reports and case series on lymphoma infiltrating the placenta
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Urorectal Septum Malformation Sequence With Retroperitoneal Neuroblastoma: A Case Report of an Unusual Association. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-09-28 Immanuel Pradeep,Naina Kumar,Poojitha Kalyani,Jitendra Singh Nigam,Shrinivas Bheemrao Somalwar,Annapurna Srirambhatla,Ashutosh Rath
Urorectal septum malformation sequence (URSMS) is an uncommon disease characterized by a failure of the anorectal septum to divide the cloaca and fuse with the cloacal membrane. Complete URSMS is usually lethal in newborn due to severe renal dysfunction and pulmonary hypoplasia. Partial URSMS is compatible with life with a single perineal opening draining a common cloaca with an imperforate anus which
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Single Umbilical Artery Umbilical Cord Is Associated With High-Grade Distal Fetal Vascular Malperfusion. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-09-28 Jerzy Stanek
PURPOSE AND CONTEXT Umbilical cord abnormalities with clinical signs of cord compromise are frequently associated with fetal vascular malperfusion (FVM). Single umbilical artery (SUA) has been reported to be associated with high-grade FVM in fetal growth restriction but not in an unselected population; our study aimed to address this issue. METHODS Clinical and placental phenotypes of 55 consecutive
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The Incidence of Multiple Fusions in a Series of Pediatric Soft Tissue and Bone Tumors. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-09-28 Anastasia MacKeracher,Anthony Arnoldo,Robert Siddaway,Lea F Surrey,Gino R Somers
BACKGROUND Next generation sequencing (NGS) has increased the detection of fusion genes in cancer. NGS has found multiple fusions in single tumor samples; however, the incidence of this in pediatric soft tissue and bone tumors (PSTBTs) is not well documented. The aim of this study is to catalogue the incidence of multiple fusions in a series of PSTBTs, and apply a modified gene fusion classification
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Time Required for Gross Examination of Routine Second and Third Trimester Singleton Placentas by Pathologists' Assistants. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-09-06 Christopher Horn,Nicole Engel,Dominique Drouin,John Haley,Cameron Holder,Lina Hung,Lorraine Royall,Patricia McInnis,Lawrence de Koning,Elaine S Chan
INTRODUCTION In both Canada and the United States, workload measurement for anatomic pathology is mainly based on complexity and clinical significance of specimens, with gross examination being a considerable contributor. While Pathologists' Assistants (PAs) play an increasing role in gross examination, there is little known regarding the time required for PAs to complete grossing tasks. This information
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Aortic Dissection and a Previously Unreported ACTA2 Missense Variant Mutation in a Young Patient: A Case Report. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-09-06 Satoshi Marutani,Takako Nishino,Osamu Shimokawa,Ritsuko K Pooh,Hiroko Morisaki,Noburu Inamura
Hereditary connective tissue disease is known to cause aortic lesions at an early age. Familial aortic aneurysm/dissection is caused due to an ACTA2 mutation that affects smooth muscle structure. We present a case of a 15-year-old boy with a mild developmental disorder in whom no abnormalities were identified on previous physical examinations. The patient presented with severe left heart failure, extensive
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Abnormal Uterine Involution May Lead to Atony and Postpartum Hemorrhage: A Hypothesis, With Review of the Evidence. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-09-06 Debra S Heller,Stewart F Cramer,Bradley M Turner
Uterine involution has 2 major components-(1) involution of vessels; and (2) involution of myometrium. Involution of vessels was addressed by Rutherford and Hertig in 1945; however, involution of myometrium has received little attention in the modern literature. We suggest that the pathophysiology of myometrial involution may lead to uterine atony and postpartum hemorrhage. The myometrium dramatically
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Maternal Hemoglobin A1c in the Third-Trimester May Underestimate Maternal Hyperglycemia and Its Impact on Offspring in Perinatal Demise Associated With Gestational Diabetes Mellitus: An Autopsy Case Series. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-09-06 Elaine S Chan,Rati Chadha,Lawrence de Koning
INTRODUCTION Gestational diabetes mellitus (GDM) is a common metabolic disorder linked to adverse pregnancy outcomes. Recent research indicates that HbA1c is reliable in detecting maternal glycemia during the first trimester but may underestimate glucose intolerance in the late second to third trimesters. Therefore, it is reasonable to hypothesize that mothers with GDM, despite apparently normal HbA1c
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Histopathologic Findings in Large for Gestational Age Placentas and Correlation With CD15 Immunohistochemistry. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-08-20 Ansa Mehreen,Sunitha Suresh,Alexa A Freedman,Linda M Ernst
BACKGROUND The histopathology and CD15 expression in large for gestational age (LGA) placentas is not well-documented. METHODS To analyze this, we utilized 2 separate cohorts of placentas from singleton term deliveries. LGA and appropriate for gestational age (AGA) placentas were compared for major histopathologies including acute and chronic inflammation, maternal and fetal vascular malperfusion,
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Placental Pathology and Its Associations With Clinical Signs in Different Subtypes of Fetal Growth Restriction. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-06-19 István Dankó,Edit Kelemen,András Tankó,Gábor Cserni
OBJECTIVE We evaluated placental alterations in different subtypes of fetal growth restriction (FGR) to determine any clinical associations. METHODS FGR placentas classified according to the Amsterdam criteria were correlated with clinical findings. Percentage of intact terminal villi and villous capillarization ratio were calculated in each specimen. Correlations of placental histopathology and perinatal
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The Placenta in Congenital Langerhans Cell Histiocytosis: A Case Report of Unusual Involvement of Chorionic Plate and Umbilical Vein. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-06-19 Muhammad Ahmad,Laura A Warren,Anam Naumaan,Nina Schatz-Siemers
The congenital presentation of Langerhans cell histiocytosis (LCH) is a rare presentation of an uncommon neoplastic process. Concurrent placental parenchymal involvement is even more rare, with just 2 cases of congenital multisystem LCH with placental involvement reported in English medical literature thus far. Here, we present a case of a liveborn male born at 37-weeks, 6-day gestation with congenital
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Correlations of Placental Histopathology, Neonatal Outcome, and Cardiotocogram Baseline Variability and Acceleration Patterns in the Growth Restricted Preterm Population. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-06-19 István Dankó,Edit Kelemen,András Tankó,Gábor Cserni
OBJECTIVE To evaluate the possible connections of cardiotocography (CTG) signs with neonatal outcome and placental histopathology between growth restricted preterms. MATERIALS AND METHODS Placental slides, baseline variability, and acceleration patterns of cardiotocograms, and neonatal parameters were studied retrospectively. Placental histopathological changes were diagnosed according to the Amsterdam
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STK11 Adnexal Tumor in an Adolescent Female: Diagnostic Pitfalls of a Recently Described Entity. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-06-19 Aarti E Sharma,Jonathan C Slack,Carlos E Parra-Herran,Bradley J Quade,Suzanne Shusterman,Alanna J Church,David L Kolin,Chrystalle Katte Carreon
STK11 adnexal tumor is a recently described entity with less than 25 cases reported to date. These aggressive tumors typically occur in paratubal/paraovarian soft tissues, have characteristically striking morphologic and immunohistochemical heterogeneity, and harbor pathognomonic alterations in STK11. These occur almost exclusively in adult patients, with only one reported in a pediatric patient (to
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Hepatocellular Adenoma: Report of 2 Cases That Highlight the Relevance of Phenotype-Genotype Correlation in the Pediatric Population. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-06-19 Jingjing Jiao,Karin E Finberg,Dhanpat Jain,Raffaella Morotti
BACKGROUND Hepatocellular adenoma (HCA) in the pediatric population is very rare and there are only limited studies, especially with molecular characterization of the tumors. Main HCA subtypes recognized in the current WHO classification include HNF1A-inactivated HCA (H-HCA), inflammatory HCA (IHCA), β-catenin-activated HCA (b-HCA), and β-catenin-activated IHCA (b-IHCA) and sonic hedgehog HCA (shHCA)
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Clinicopathologic Features of IDEDNIK (MEDNIK) Syndrome in a Term Infant: Histopathologic Features of the Gastrointestinal Tract and Report of a Novel AP1S1 Variant. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-06-06 Jiajie G Lu,Shweta S Namjoshi,Annie D Niehaus,Shawn Tahata,Chung Un Lee,Lin Wang,Erin McDonnell,Melissa Seely,Martin G Martin,Florette K Hazard
Inherited syndromes of congenital enteropathy are rare, with many genetic causes described. Mutations of the AP1S1 gene results in the syndrome of intellectual disability, enteropathy, deafness, peripheral neuropathy, ichthyosis, and keratoderma (IDEDNIK, formerly in the medical literature as MEDNIK). The clinicopathologic features of the enteropathy in IDEDNIK syndrome have not been fully explored
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Anatomy of the Ductus Arteriosus in Fetal Autopsies: Correlations With Placental Pathology and Cause of Death. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-05-30 Linda M Ernst,Alexa Freedman,Erica Price,Andrew Franklin
BACKGROUND Differences in the shape of the ductus arteriosus (DA), an important vascular shunt between the pulmonary artery and aorta, may reflect fetoplacental blood flow. Our aim was to examine tapering of the DA in a fetal autopsy population and correlate it with placental pathology and cause of death (COD). METHODS This autopsy case control study of stillborn fetuses selected cases (tapered DA)
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Pediatric Gnathic Bony and Mesenchymal Tumors. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-05-26 Yingci Liu,Molly Housley Smith,Paras B Patel,Elizabeth Ann Bilodeau
Evaluation of bone pathology within the head and neck region, particularly the gnathic bonesis is complex, demonstrating unique pathologic processes. In part, this variation is due to odontogenesis and the embryological cells that may be involved, which can contribute to disease development and histologic variability. As with any boney pathosis, the key is to have clinical correlation, particularly
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C4d Staining Is Present in Normal Placentas From Pregnancies Prior to Pregnancy Loss Associated With Chronic Histiocytic Intervillositis and Is Reduced by Immunomodulatory Therapy in Subsequent Pregnancies. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-05-26 Elaine S Chan,Lawrence de Koning,Weiming Yu,Rati Chadha
INTRODUCTION Chronic histiocytic intervillositis (CHI) is associated with adverse pregnancy outcomes and high recurrence risk. Recent studies suggest that CHI may represent a host-vs-graft rejection, and that C4d immunostain can be used as a marker for complement activation and antibody-mediated rejection in the CHI. MATERIALS AND METHODS This retrospective cohort study focused on 5 fetal autopsy cases
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Dermoid Cyst of the Round Ligament in a 3-Year-Old-Girl. Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-05-22 Javier Arredondo Montero,Ada Yessenia Molina Caballero,Mónica Bronte Anaut,Rosa Guarch Troyas,Alberto Pérez-Martínez
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Temperature behavior of cable-stayed bridges. Part II — temperature actions by using unified analysis Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-05-15 Yushi Shan, Qiang Jing, Lingfang Li, Wenbo Gao, Zili Xia, Yong Xia
The temperature action of long-span cable-stayed bridges is complicated because of the high indeterminacy of their structure. Previous studies on the temperature behavior of bridges were either lim...
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Investigation into Grief Experiences of the Bereaved During the Covid-19 Pandemic Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-05-15 Mohammad Asgari, Mahdi Ghasemzadeh, Asgar Alimohamadi, Shiva Sakhaei, Clare Killikelly, Elham Nikfar
The objective of the current study was to investigate the grief experiences of people affected by COVID-19. The study adopted a qualitative design of descriptive phenomenology. Fifteen adults who h...
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Status of homestay tourism in Indian Himalayan region: Analysis of customer review and policy support for sustainable tourism Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-05-15 Smriti Thakur, Sagar Sood, Rakesh Kumar Singh, Ranjeet Singh
Homestays, which have emerged as a popular idea in the growing tourism industry, act as the most suitable alternative to encourage sustainable tourism activities in the Indian Himalayan Region (IHR...
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The response of geographical processes to landscape restoration: China’s research progress Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-05-15 Yanxu Liu, Yu Han, Jincheng Wu, Chenxu Wang, Bojie Fu
The UN Decade of Ecosystem Restoration (2021–2030) provides a new momentum for scaling up ecosystem restoration efforts to landscape restoration. China’s recent experience with transformative inves...
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Death Anxiety and Accosiated Factors Among Oncology Nurses and Physicians Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-05-15 Bushra Alhusamiah, Ruqayya S. Zeilani
Background: Providing care for dying patients is a stress-inducing, complicated, as well as essential responsibility for health care providers. Furthermore, end-of-life care is associated with inte...
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Research on signal separation method of micro-speed difference dual-rotor based on ZFFT and FT algorithm Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-05-15 Zhang Meng, Lu Jiaqiao, Pan Xin
Aiming at the problem that the traditional analysis methods such as Zoom-FFT (ZFFT) heavily depend on the data length in the frequency separation accuracy when separating the unbalanced signals of ...
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Study on excitation threshold of strong modulation response and vibration suppression performance of bistable nonlinear energy sink Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-05-15 Yujiang Wang, Haiyan Yang, Weizhi Song, Chihua Lu, Zhien Liu, Hui Zhou
The dynamics and vibration reduction performance of bistable nonlinear energy sink (BNES) are studied in this paper. First, the negative stiffness of BNES is realized by geometric nonlinearity, and...
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Durability of bond between carbon/glass hybrid fiber-reinforced polymer (HFRP) bar and concrete in water Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-05-15 Gaojie Xu, Yixun Yu, Yunfeng Pan, Biao Li
Glass-fiber-reinforced polymer (GFRP) bars have been widely used as a reinforcement in concrete, and glass fibers are susceptible to reacting with alkali ions in concrete pores. Thus, carbon fibers...
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Pulmonary Histopathologic Findings in Pediatric Patients After Hematopoietic Stem Cell Transplantation: An Autopsy Study Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-05-10 Nahir Cortes-Santiago, Kalyani R. Patel, Hao Wu, Sarah E. Sartain, Saleh Bhar, Manuel Silva-Carmona, Jennifer Pogoriler
Background:Pathologic characterization of pulmonary complications following hematopoietic stem cell transplantation (HSCT) is limited. We describe lung findings in pediatric patients who died follo...
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Current Utilization of Electron Microscopy in the Pediatric Pathology Setting: A Survey by the SPP Practice Committee Pediatr. Devel. Pathol. (IF 1.9) Pub Date : 2023-05-10 Mikako Warren, Robyn C. Reed, Vinay Prasad, Veena Rajaram, Drucilla Roberts, Portia A. Kreiger, Lora Darrisaw, Sherri Besmer, Alanna J. Church, Matthew Keisling, Randall D. Craver, Bonnie L. Cole, James Robers, Dolores Lopez-Terrada
Background:Electron microscopy (EM), once an important component in diagnosing pediatric diseases, has experienced a decline in its use. To assess the impact of this, pediatric pathology practices ...