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Cannonball Pulmonary Metastases as Initial Presentation of Hepatocellular Carcinoma: A Case Report and Literature Review Egypt. Liver J. Pub Date : 2024-04-15 Héctor Raúl Ibarra-Sifuentes, Gustavo Abraham Canales-Azcona, Jaqueline Isabel Gómez-Arredondo, Carlos Javier Rodríguez-Álvarez
Hepatocellular carcinoma is a major public health problem, as is considered the fastest growing cause of cancer-related death. Cannonball metastases as an initial finding in hepatocellular carcinoma are considered a rare phenomenon. A 59-year-old man presented to the outpatient clinic for subacute cough, asthenia, and involuntary weight loss. Chest X-ray showed multiple, round, bilateral pulmonary
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Clinical and epidemiological characterization of eosinophilic ascites in Egypt: a single center experience Egypt. Liver J. Pub Date : 2024-04-03 Mohammed Ahmed Medhat, Mohamed O. Abdelmalek, Mohamed A. Mekky, Sherief Abd-Elsalam, Mohamed Ahmed Yehya Abdel-Malek, Sayed Hassan Ahmed, Yusuf S. Amry, Waleed Attia Hassan
Eosinophilic ascites is non-common and challenging disease. This study aimed to describe the clinical presentation and treatment of eosinophilic ascites. This was a prospective single-center study that included cases with eosinophilic ascites who were admitted to Tropical Medicine and Gastroenterology Department, Assiut University Hospital, Assiut, Egypt, during the period between May 2020 to May 2023
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Investigating the effect of serum level of uric acid on the immunogenicity of hepatitis B vaccination in dialysis patients Egypt. Liver J. Pub Date : 2024-04-02 Nasibe Golestani, Najmeh Shamspour, Jalal Azmandian, Habibeh Ahmadipour, Mahdi Karamipour zarei
HBV infection is a significant concern in dialysis patients, influenced by various factors. This study aims to investigate the impact of serum uric acid levels on the immunogenicity of hepatitis Bvaccination in dialysis patients. A cross-sectional study was conducted, involving 125 hemodialysis patients. Prior to dialysis, assessments were made for uric acid, vitamin D, HBsAg, andHBsAb. Patients were
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Obesity prevalence in adults and patients with hepatitis C: results from screening a population of 50 million in Egypt Egypt. Liver J. Pub Date : 2024-04-01 Gamal Esmat, Hala Zaid, Mohamed Hassany, Wael Abdel-Razek, Magdy El-Serafy, Wafaa El Akel, Aysam Salah, Ehab Kamal, Galal Elshishiney, Islam Ammar, Khaled Kabil, Mohamed AbdAllah, Ramy Saeed, Tarek Saad, Yasser Omar, Hany Dabbous, Manal H. El-Sayed, Yehia El Shazly, Wahid Doss, Imam Waked
Obesity is a global health problem and has been increasing in Egypt over the last several decades. A national population screening program for hepatitis C included screening for obesity. Here we report the outcome of body mass index (BMI) calculation for the screened population and for patients with hepatitis C. Methods Adults 18 years and older (a target population of 62.5 million) were invited to
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Correlation of non-alcoholic fatty liver disease and gut microflora: clinical reports and treatment options Egypt. Liver J. Pub Date : 2024-04-01 Pranali A. Jadhav, Asha B. Thomas, Rabindra K. Nanda, Sohan S. Chitlange
A prevalent liver condition called non-alcoholic fatty liver disease (NAFLD) may progress into non-alcoholic steatohepatitis (NASH) and cause life-threatening complications like cirrhosis and liver cancer. The development and progression of NAFLD has been linked to the make-up and functioning of the gut microflora. This article reviews the clinical studies reported to investigate the connection between
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Acute hepatitis A complicated by encephalitis: a case report and literature review Egypt. Liver J. Pub Date : 2024-03-19 Reham Ashour, Rahma Ibrahim, Ammar Muhammed
Hepatitis A is the most common cause of acute hepatitis around the globe, especially in developing countries. It often presents with signs and symptoms related to the gastrointestinal system. However, it rarely presents extrahepatic manifestations, which can be more common in adults than in children. We report a unique case of hepatitis A presenting with encephalitis that was resolved conservatively
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Exploring the prognostic significance of blood carnitine and acylcarnitines in hepatitis C virus-induced hepatocellular carcinoma Egypt. Liver J. Pub Date : 2024-03-18 Ashraf Abbass, Azza El Sheashaey, Ashraf El Fert, Manar Obada, Eman Abdelsameea, Mohammed Abdel-Samiee, Asmaa Ibrahim, Ashraf Khalil
Hepatic energy metabolism is intricately linked with the metabolic changes associated with HCV infection and hepatocellular carcinoma (HCC). This study investigated the potential of carnitine and acylcarnitines as markers for monitoring the development and progression of HCC in the context of HCV-induced liver cirrhosis. Blood samples from patients with chronic liver cirrhosis due to HCV (n = 55) and
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Effectiveness and safety of SOF/VEL containing rescue therapy in treating chronic HCV-GT4 patients previously failed NS5A inhibitors-based DAAs Egypt. Liver J. Pub Date : 2024-03-11 Heba Omar, Mohammed Hamdy Abdel Maksoud, Ahmed A. Goma, Essam A. Hassan, Nancy Abdalla Atta, Mahmoud Khalil, Mohamed Soliman Hegazy, Samy Zaky, Gamal Esmat
NS5A inhibitors are an important option for treating chronic HCV-GT4 patients. Retreatments after NS5A-based DAAs failure are limited. We aimed to determine the effectiveness and safety of SOF/VEL-containing regimens for HCV retreatment after NS5A-regimen failure. Prospective cohort study assessing the efficacy and safety of retreatment with SOF/VEL in addition to either voxilaprevir or ribavirin in
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Bile duct matrix metalloproteinase-7 expression: a new modality for diagnosis of biliary atresia Egypt. Liver J. Pub Date : 2024-03-09 Alif Abdelhakim Allam, Mohammed Ahmed Khedr, Shimaa Saad Elkholy, Takwa Abd El Rahman Yassin, Ola Ahmed Fouad
Biliary atresia (BA) is an obliterative cholangiopathy of infancy that results in cholestasis and liver fibrosis. This fibrosis is due to an imbalance in extracellular matrix (ECM) breakdown and deposition. The mechanism by which the progressive injury occurs is not fully elucidated. Matrix metalloproteinases (MMPs) are involved in ECM turnover but also have non-ECM-related functions. Matrix metalloproteinase
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The coagulation changes associated with acute variceal bleeding in patients with HCV-induced cirrhosis as assessed by rotational thromboelastometry Egypt. Liver J. Pub Date : 2024-03-08 Mona A. Abu El-Makarem, Aml A. Mohammad, Ola A. Afifi, Nehal I. Abbas, Tarek A. Abd El-Zaher, Safaa M. Abdel Halim, Aliaa S. Abd El-Fattah
Alterations of hemostasis in patients with decompensated cirrhosis are complex. Accordingly, standard coagulation tests are not feasible to evaluate bleeding risk in these patients. The aim of this study was to assess the coagulation kinetics in cirrhotic patients with variceal bleeding using rotational thromboelastometry (ROTEM). ROTEM including EXTEM, INTEM, and FIBTEM which represent extrinsic,
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Protective and therapeutic effects of apigenin on thioacetamide-induced hepatotoxicity in male rats: physiological and morphological study Egypt. Liver J. Pub Date : 2024-03-05 Zaenah Zuhair Alamri
Liver fibrosis is an irreversible liver destruction. Apigenin (API) has different pharmacological properties as anticancer, anti-inflammatory, and antioxidant; however, API hepatoprotective and therapeutic effects are not often studied. This study assesses protective and therapeutic API effects on hepatic injuries produced by thioacetamide (TAA) in rats. Forty-nine rats were sorted into seven groups
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Impact of treating chronic hepatitis C with direct acting antivirals on health-related quality of life: a real-life Egyptian experience Egypt. Liver J. Pub Date : 2024-02-27 Mohamed Elbadry, Mahmoud Badawi, Naglaa Youssef, Martin Duracinsky, Shereen A. Saleh, Anna Funk, Hagar Elessawy, Eva Rumpler, Khadiga Sayed, Anca Vasiliu, Yoann Madec, Arnaud Fontanet, Mohamed El-Kassas
Chronic hepatitis C virus (HCV) infection negatively impacts health-related quality of life (HRQL). We aimed to assess patient-reported outcomes (PROs) to evaluate the impact of treating chronic HCV with directly acting antivirals (DAAs) on HRQL. PROs were assessed prospectively using the PROQOL-HCV questionnaire before (week 0), at the end (week 12), and after DAA treatment at week 24. HRQL was measured
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A 28-year-old male patient with asymptomatic and multi-drug-resistant HBV infection: a case report Egypt. Liver J. Pub Date : 2024-02-26 Syed Ayaz Kazmi, Abdul Rauf, Muhammad Zahid Latif, Beenish Shahid, Sundus Khawaja, Zeeshan Anjum
Chronic hepatitis B virus (HBV) infection poses a significant global health challenge, impacting millions of individuals and elevating the risk of morbidity and mortality. Antiviral therapies are the primary treatment for chronic HBV infection, but treatment resistance can occur, leading to poor clinical outcomes and an increased risk of liver complications. This case report presents the clinical trajectory
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Diagnostic role of serum brain-derived neurotrophic factor in HCV cirrhotic patients with minimal hepatic encephalopathy with and without schistosomiasis Egypt. Liver J. Pub Date : 2024-02-19 Essam S. Bedewy, Abeer Elhadidi, Naglaa Abd El-Latif, Yousra T. El Zawawy, Amany N. Abbasy
Liver cirrhosis (LC) advances from an asymptomatic phase (compensated cirrhosis) to a symptomatic phase (decompensated cirrhosis). Up to 80% of patients with LC may experience minimal hepatic encephalopathy (MHE), which is the first stage of hepatic encephalopathy (HE). Due to the lack of serum indicators, the diagnosis of MHE is frequently based on neuropsychometric tests. Therefore, this study aimed
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Tissue inhibitor of matrix metalloprotinase-1 and collagen type IV in HCV-associated cirrhosis and grading of esophageal varices Egypt. Liver J. Pub Date : 2024-02-19 Nasser Mohamed Abdalla, Fatma Mohamed Abd El Aziz, Akram Deghady, Mohamed Helmy Abaza, Walid Ismail Ellakany
Esophageal varices are abnormally dilated submucosal veins of the esophagus which develop as a result of portal hypertension due to cirrhosis. Collagen type IV is upregulated with a 14-fold increase in cirrhosis. Tissue inhibitor of metalloproteinases-1 (TIMP-1) is also upregulated during hepatic fibrogenesis and considered to promote fibrosis in the injured liver. The objective of this research was
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Serum level of hepcidin in cirrhotic patients as a marker for hepatocellular carcinoma Egypt. Liver J. Pub Date : 2024-02-14 Khaled Mahmoud Mohiedeen, Mona Moustafa Tahoon, Christina Samir Sadek Hanna, Mohamed Adel Abdel Aziz
People all around the world are affected by primary liver cancers like hepatocellular carcinoma (HCC), which is usually associated with cirrhosis. Early HCC detection is crucial for better prognosis, but effective biomarkers are still needed. Hepcidin, a hormone-regulating iron homeostasis, has been implicated in liver diseases. In this study, blood hepcidin levels were evaluated in cirrhotic individuals
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Splenic artery aneurysm rupture in a pregnant woman with hepatosplenic schistosomiasis: case report and literature review Egypt. Liver J. Pub Date : 2024-01-29 Chantelli Iamblaudiot Razafindrazoto, Antsa Fihobiana Randrianiaina, Behoavy Mahafaly Ralaizanaka, Henintsoa Rakotoniaina, Nitah Harivony Randriamifidy, Anjaramalala Sitraka Rasolonjatovo, Andry Lalaina Rinà Rakotozafindrabe, Tovo Harimanana Rabenjanahary, Soloniaina Hélio Razafimahefa, Rado Manitrala Ramanampamonjy
Pregnancy is not uncommon in patients with non-cirrhotic portal hypertension. Rupture of a splenic artery aneurysm remains a rare complication, associated with a very poor maternal–fetal prognosis. Our aim is to report a case of ruptured splenic aneurysm and to show the maternal–fetal over-risks during the association of pregnancy and portal hypertension, even in non-cirrhotic patients. We report a
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Can the FIB-4 score predict the severity of acute pancreatitis in NAFLD? Egypt. Liver J. Pub Date : 2024-01-27 Kutay Kirdok, Özge Yogurtcu, Tahir Buran, Elmas Kasap
Non-alcoholic fatty liver disease (NAFLD) is a liver pathology. NAFLD’s prevalence is increasing in the world and because of the increase non-invasive methods are gaining importance in diagnosis. The Fibrosis 4 (FIB-4) score is one of the most commonly used non-invasive scoring methods for diagnosing NAFLD today. Acute pancreatitis is a disease with inflammation and high morbidity. There are studies
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Safety, risk stratification, and cost of ERCP in patients with cirrhosis: a prospective controlled study Egypt. Liver J. Pub Date : 2024-01-20 Ahmed Attia
Given that ERCP has major procedure-related complications in non-cirrhotic patients, the complications and the cost of therapeutic ERCP were not studied in cirrhotic patients. We aimed to study the complications and cost of ERCP compared to patients without cirrhosis. Outcome and complications of therapeutic ERCP were prospectively studied in patients with cirrhosis and compared to patients without
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Diagnostic and prognostic significance of tissue lncRNA HOTAIR and hexokinase 2 mRNA expression in patients with pancreatic ductal adenocarcinoma Egypt. Liver J. Pub Date : 2024-01-18 Ghada Salah, Manar Obada, Dina Sweed, Ibrahim Abdelkader Salama, Ashraf Khalil, Shimaa Abdelsattar
Pancreatic adenocarcinoma, recognized for its aggressive behavior and frequent late-stage diagnosis, imposes significant challenges in early detection and prognosis. This study aimed to evaluate the diagnostic and prognostic potential by measuring the expression levels of long non-coding RNA HOTAIR and the glycolytic enzyme hexokinase 2 (HK2) mRNA in both tumorous and adjacent non-tumorous pancreatic
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The value of simultaneous determination of blood large neutral amino acids and tetrahydrobiopterin metabolites in the diagnosis of atypical hyperphenylalaninemia Egypt. Liver J. Pub Date : 2024-01-17 Nadia Salama, Gamalte Elgedawy, Radwa Gamal, Osama Zaki, Ashraf Khalil, Manar Obada
Tetrahydrobiopterin deficiency in newborns with atypical hyperphenylalaninemia requires rapid and accurate diagnosis and the ability to distinguish it from the classical type to prevent early irreversible neurological damage. The study aimed to evaluate neopterin and biopterin (products of tetrahydrobiopterin recycling pathway) and amino acid profiles (used in supplementation therapy) in patients with
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Expression of PD-L1 clones (22C3 and 28-8) in hepatocellular carcinoma: a tertiary cancer care hospital experience Egypt. Liver J. Pub Date : 2024-01-17 Kashif Asghar, Shaarif Bashir, Muhammad Hassan, Asim Farooq, Muhammad Abu Bakar, Sundus Bilal, Maryam Hameed, Shafqat Mehmood, Asif Loya
Hepatocellular carcinoma (HCC) is a highly aggressive and rapidly progressing form of cancer with a poor prognosis. Recent advances in the management of HCC focused on the novel immunotherapeutic modalities for patients with advanced disease. PD-L1 has emerged as a promising immunotherapeutic approach for HCC. The evaluation of PD-L1 expression aids in identifying patients who can derive maximum benefits
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Evaluation of serum thioredoxin as a hepatocellular carcinoma diagnostic marker Egypt. Liver J. Pub Date : 2024-01-08 Khaled Mohamed Abdelwahab, Wesam Ahmed Ibrahim, Shereen Abou Bakr Saleh, Anas Abdelfattah Abdelaziz Elbarky, Ghada Abdelrahman Mohamed
Hepatocellular carcinoma (HCC) is one of the most prevalent and fatal malignancies worldwide. Following an increase in reactive oxygen species (ROS), cancer cells enter an oxidative stress state. As a result, these cells experience an increase in antioxidant activity to counteract oxidative stress. The thioredoxin (TRX) system is a ubiquitous mammalian antioxidant system that neutralizes ROS and maintains
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Latest advances in hepatocellular carcinoma management and prevention through advanced technologies Egypt. Liver J. Pub Date : 2024-01-02 Tamer A. Addissouky, Ibrahim El Tantawy El Sayed, Majeed M. A. Ali, Yuliang Wang, Ayman El Baz, Ahmed A. Khalil, Naglaa Elarabany
Hepatocellular carcinoma (HCC) is a common type of liver cancer, with a high mortality rate. Hepatocellular carcinoma is a type of liver cancer that can be effectively managed through early detection and accurate diagnosis, followed by a personalized treatment plan that may include surgical resection, liver transplantation, minimally-invasive techniques, immunotherapy, or targeted therapy depending
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Epidemiologic data on acute gastrointestinal bleeding in Albania: an overview of upper and lower GI bleeding Egypt. Liver J. Pub Date : 2024-01-02 Edite Sadiku, Liri Cuko, Ina Pasho, Orion Jucja, Stela Taci, Kliti Hoti, Bledar Kraja
Acute gastrointestinal bleeding (GIB) is a significant medical condition that poses a considerable burden on healthcare systems worldwide. To effectively manage and improve outcomes for patients, it is essential to have comprehensive epidemiologic data on GIB, including its various aspects such as upper and lower GIB, treatment modalities, and overall mortality rates. The objective of this study is
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Correction: Hepatic artery infusion chemotherapy for advanced hepatocellular carcinoma Egypt. Liver J. Pub Date : 2023-12-18 Mohamed Houseni, Mahmoud Abdel Aziz Abdel Hady, Sameh Abokoura
Correction: Egypt Liver Journal 13, 41 (2023) https://doi.org/10.1186/s43066-023-00276-6 Following publication of the original article [1], the abstract and keywords were missing from this article and should have read: Abstract Objective: This study’s purpose was to evaluate the response, safety and overall survival of trans-arterial infusion chemotherapy in patients with advanced hepatocellular carcinoma
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Misdiagnosed cystic pancreatic neuroendocrine tumor with bilobar hepatic metastasis managed with single-stage resection — a case report Egypt. Liver J. Pub Date : 2023-12-18 Maham Nasir Uddin, Muhammad Arsalan Khan, Abdaal Waseem Khan
Pancreatic neuroendocrine tumors (PNET) account for less than 2% of all pancreatic tumors, while cystic PNETs account for only 10–18% of all resected PNETs. The most common site for metastasis is the liver. Few detailed guidelines currently exist for management of stage 4 cystic PNETs. This is a unique case that was managed with complete surgical resection in one sitting. Our report is on a young male
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Pneumo-mediastinum, pneumoperitoneum, and pneumo-scrotum with extensive increasing subcutaneous emphysema: a rare presentation of colonic perforation Egypt. Liver J. Pub Date : 2023-11-22 Kulbhushan Haldeniya, S. R. Krishna, Annagiri Raghavendra, Pawan Kumar Singh
Colonic perforation usually presents with classical signs of peritonitis. However, isolated retroperitoneal colonic perforation can present with varied clinical signs and symptoms and pose diagnostic challenges. Pneumo-mediastinum and abdominal subcutaneous emphysema can be one of the presenting signs of colonic perforation. A 33-year-old male presented with abdominal distension and extensive subcutaneous
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Liver injury in malaria infected patients in Douala-Cameroon and its association with poor medical practice Egypt. Liver J. Pub Date : 2023-11-22 Arnaud Fondjo Kouam, Noé Auguste Nseké Ngoumé, Armelle Gaelle Kwesseu Fepa, Zerubabel Wainfen, Eléonore Ngounou, Borris Rosnay Tietcheu Galani, Nembu Erastus Nembo, Pascal Dieudonné Djamen Chuisseu, Fréderic Nico Njayou, Paul Fewou Moundipa
Malaria is an endemic mosquito-borne disease in sub-Saharan regions, including Cameroon. Due to the obligatory hepatic stage of its pathogenic agents, malaria can induce liver damage if not properly treated. Hence, we assessed the impact of malaria infection on liver transaminases among febrile patients consulting at the Deido District Hospital, Douala-Cameroon, in regard to their attitude towards
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Association between the severity of liver cirrhosis with quality of life and its impact on clinical practice Egypt. Liver J. Pub Date : 2023-11-21 Syifa Mustika, Jefri Pratama Susanto, Cosmas Rinaldi Adithya Lesmana
Liver cirrhosis (LC) has a significant impact in quality of life, and it is frequently linked to loss of a job, mood fluctuations, anxiety, low self-esteem, and despair. Recent LC treatment primarily focuses on clinical manifestations rather than the patient’s quality of life. By analyzing quality of life, one can learn about the disease’s emotional, physical, and lifestyle effects. To find the relationship
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An interesting case report of delayed presentation of post-cholecystectomy benign biliary stricture Egypt. Liver J. Pub Date : 2023-11-20 Kulbhushan Haldeniya, Niranjan Rajkumar Gandhi, Haritha Gorantla, Sindhura Bukka
Background The most common cause of benign biliary stricture is bile duct injury after cholecystectomy. Benign biliary strictures are associated with a broad spectrum of signs and symptoms, ranging from subclinical disease with mild elevation of liver enzymes to complete obstruction with jaundice, pruritis, and cholangitis ultimately leading to biliary cirrhosis. The average duration for stricture
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Can probiotics play a role in Helicobacter pylori (H. Pylori) eradication? Egypt. Liver J. Pub Date : 2023-11-18 Sameh Mohamed Fakhry, Mohamed Abdel-Hameed Kandyl, Adel Ferig Hashish, Wafaa Kandeel, Ahmed Mostafa El-Shenawy, Hoda Samir El-Sayed, Mohamed Kamal Dewidar, Sameh Mohamed Badr, Nayra Shaker Mehanna
H. Pylori is one of the commonest infectious diseases worldwide. In recent years, PPI-based triple therapy has been described to be losing its efficacy against H. pylori due to high rates of antibiotic resistance, antibiotics-associated side effects, and low compliance. Probiotics are suggested to improve the H. pylori eradication rate when added to H pylori therapy. Probiotics have anti-inflammatory
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The association between non-alcoholic fatty liver disease and chronic kidney disease in Egyptian patients Egypt. Liver J. Pub Date : 2023-11-16 Heba El Sayed Kasem, Ehab Ahmed Abdelatty, Ahmed Mohamed Mokhtar Yahia, Ezzat Mohamed Abdalla
NAFLD is a spectrum of disorders ranging from hepatic steatosis to nonalcoholic steatohepatitis (NASH), NASH related cirrhosis and hepatocellular carcinoma (HCC). There is sparse data on the prevalence CKD in Egyptian patients with NAFLD. The aim of this study is to estimate the prevalence of CKD in the subjects with NAFLD and to assess the risk factors of CKD among them. A cross-sectional study was
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Alagille syndrome and liver: an adult case report Egypt. Liver J. Pub Date : 2023-11-11 Oussama Kharmach, Mohamed Borahma, Fatima-Zohra Ajana
Alagille syndrome is a rare autosomal-dominant disorder, representing 10 to 15% of the causes of neonatal cholestasis with no gender predominance. The diagnosis is based on the association of liver, heart, eye, skeleton abnormalities, and characteristic facial appearance. An 18-year-old male patient, with a family history of benign recurrent intrahepatic cholestasis in a brother, was diagnosed at birth
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Complexities in liver biopsy: the role of navigation and fusion imaging Egypt. Liver J. Pub Date : 2023-11-03 Serah Jessy Mathew, Anchal Nayak, Sagnika Dash, Sarada Prasad Dakua
Liver biopsy is crucial to know if the tumor is benign or malignant. This paper has reviewed the literature clinically shedding lights on the present biopsy procedure, requirements, and potential challenges. This study has emphasized the role of navigation during liver biopsy. It has discussed the various imaging modalities used for biopsy. The potential limitations of imaging modalities have been
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Endoscopic variceal ligation in primary and secondary prevention of variceal bleeding: a retrospective study in Digestive Endoscopy Unit, University Hospital Joseph Raseta Befelatanana, Antananarivo, Madagascar Egypt. Liver J. Pub Date : 2023-10-31 Chantelli Iamblaudiot Razafindrazoto, Nitah Harivony Randriamifidy, Jolivet Auguste Rakotomalala, Sedera Radoniaina Rakotondrasoa, Behoavy Mahafaly Ralaizanaka, Henintsoa Rakotoniaina, Antsa Fihobiana Randrianiaina, Mialitiana Rakotomaharo, Domoina Harivonjy Hasina Laingonirina, Sonny Maherison, Anjaramalala Sitraka Rasolonjatovo, Andry Lalaina Rinà Rakotozafindrabe, Tovo Harimanana Rabenjanahary,
Endoscopic variceal ligation (EVL) is a crucial procedure for the primary and secondary prevention of variceal bleeding. The objective of this study was to evaluate the efficacy and tolerability of EVL in the prevention of variceal bleeding. This was a retrospective, single-center study over 8 years, from January 2013 to December 2020, including all patients who came for EVL in primary or secondary
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Relationship between BDNF gene polymorphisms and alcohol-related liver cirrhosis Egypt. Liver J. Pub Date : 2023-10-25 Danil I. Peregud, Valeria Yu. Baronets, Anna S. Lobacheva, Alexandr S. Ivanov, Irina V. Garmash, Olga S. Arisheva, Zhanna D. Kobalava, Sergey V. Pirozhkov, Natalia N. Terebilina
Brain-derived neurotrophic factor (BDNF) functions not only in the brain but also in peripheral tissues such as the liver. Genetic factors determine the development of alcohol dependence and somatic consequences of chronic intoxication, especially liver cirrhosis. The BDNF gene polymorphisms are associated with alcohol dependence; however, their relationship with the development of alcohol-related
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Progression of pancreatic branch duct-type intraductal papillary mucinous neoplasms (BD-IPMNs) after surgery for extrapancreatic malignancies Egypt. Liver J. Pub Date : 2023-10-25 Akira Imoto, Takeshi Ogura, Daisuke Masuda, Ken Narabayashi, Toshihiko Okada, Yosuke Abe, Toshihisa Takeuchi, Takuya Inoue, Kumi Ishida, Sadaharu Nouda, Kazuhide Higuchi, Usama M. Abdelaal
The natural history of pancreatic branch duct-type intraductal papillary mucinous neoplasms (BD-IPMNs) is still unknown. This retrospective study aims to determine the morphological changes of BD-IPMNs with attention to the history of surgical resection for extrapancreatic malignancies. This study included 427 subjects with BD-IPMN at the Osaka Medical College from January 2001 to December 2019; 134
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Health-related quality of life and its determinants among South Indian type 2 diabetes patients with and without non-alcoholic fatty liver disease Egypt. Liver J. Pub Date : 2023-10-12 Usha Sree Puneem, Vanitha Rani Nagasubramanian, Vasudeva Murthy Sindgi, Subburaya Mudaliyar Rajendran Ramakrishnan, Ranakishor Pelluri
Non-alcoholic fatty liver disease (NAFLD) is one of the leading causes of chronic liver disease in type-2 diabetics. The quality of life among those patients was not explored well. Hence, the present study aimed to correlate the determinants with the quality of life (QoL) among the study subjects. A hospital-based case–control study was conducted at Bhargavi Gastro and Surgical Hospital, Warangal,
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Validity of serum resistin level and Il-6 as prognostic biomarkers of decompensated liver cirrhosis in chronic hepatitis C virus patients Egypt. Liver J. Pub Date : 2023-10-12 Ayman F. El-Shayeb, Akram A. Degheidy, Sawsan El-Mallah, John Farid, Amany N. Abbasy
Decompensated liver cirrhosis (DLC) is now known as a chronic inflammatory process, evidenced by elevated levels of circulatory pro-inflammatory cytokines and chemokines which in turn lead to the development of more hepatic decompensation and multi-organ failure. Resistin has a pro-inflammatory effect through the production of several cytokines (e.g., IL-1, IL-6, IL-12, and TNF-α) and cell adhesion
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A rare gastrointestinal bleeding due to a cholecystoduodenal fistula: a case report Egypt. Liver J. Pub Date : 2023-10-11 Maddalena Zippi, Antonella Toma, Wandong Hong, Sirio Fiorino, Alfonso Grottesi
Gastrointestinal bleeding from cholecystoduodenal fistula is rare. It is usually managed surgically, although a conservative approach is reported in isolated cases. A 71-year-old male patient was admitted to the emergency department (ED) presenting melena associated with severe anemia, requiring a blood transfusion. An urgent upper endoscopy showed the intestinal orifice of a cholecystoduodenal fistula
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Study of transcription factor 7-like 2 (TCF7L2) gene polymorphism in cirrhotic patients with diabetes Egypt. Liver J. Pub Date : 2023-10-05 Mona Mahmoud Hassouna, Mohammed Sayed Moustafa, Mona Hamdy, Eman Abdelsameea, Mohamed Abbasy, Mary Naguib
Patients with chronic liver disease (CLD) as chronic hepatitis C (CHC) are at high risk of diabetes type 2 (T2D). Genetic factors are suggested to modulate diabetes development in cirrhotic patients. TCF7L2 gene has been reported to be associated with type 2 diabetes, but the association of TCF7L2 with cirrhotic patients with diabetes is unclear. We aimed to study the TCF7L2 gene polymorphisms (rs
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Baseline and recurrent exposure to the standard dose of artemisinin-based combination therapies (ACTs) induces oxidative stress and liver damage in mice (BALB/c) Egypt. Liver J. Pub Date : 2023-10-05 David Audu, Vinood B. Patel, Olufunmilayo A. Idowu, Fakilahyel M. Mshelbwala, Adewumi B. Idowu
In malaria-endemic countries, repeated intake of artemisinin-based combination therapies (ACTs) is rampant and driven by drug resistance, improper usage, and easy accessibility. Stress effects and potential liver toxicity due to the frequent therapeutic use of ACTs have not been extensively studied. Here, we investigated the effects of repeated treatment with standard doses of the commonly used ACTs
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MRI features for predicting the pathological grade of HCC in patients undergoing liver transplantation Egypt. Liver J. Pub Date : 2023-10-05 Aylin Altan Kus, Selim Keceoglu, Ali Ozer
Contrast-enhanced magnetic resonance imaging (MRI) plays a crucial role in the diagnosis of hepatocellular carcinoma (HCC). This study aims to assess the performance of MRI features for evaluating hepatocellular carcinoma (HCC) aggressiveness in living liver transplantation in patients. This retrospective study included patients who underwent liver transplantation in our hospital between 2015 and 2020
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The novel approach for non-invasive diagnostic biomarkers from an early stage of NAFLD to advanced fibrosis Egypt. Liver J. Pub Date : 2023-10-04 Pooja Dudeja, Taishee Pal, Aman Sharma
Non-alcoholic fatty liver disease (NAFLD) is a spectrum of disorders that will be started from more than or equal to 5% of fats deposited into the liver hepatocyte cells and progressively leads to steatosis, further increment in fat deposition, and signature of inflammatory markers which cause the non-alcoholic steatohepatitis (NASH) condition. Due to a lack of diagnosis and effective treatment, NASH
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The implications of the COVID-19 pandemic on hepatitis B and C elimination programs in Egypt: current situation and future perspective Egypt. Liver J. Pub Date : 2023-10-04 Aisha Elsharkawy, Reham Samir, Mohamed Abdallah, Mohamed Hassany, Mohamed El-Kassas
Hepatitis B virus (HBV) and hepatitis C virus (HCV) are amongst the most common causative agents of viral hepatitis with its severe complications, including liver cirrhosis, decompensation, and hepatocellular carcinoma (HCC). Elimination of viral hepatitis, a significant challenge, has become an adopted global goal with certainly designed targets set by the World Health Assembly to be met by 2030.
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Assessment of hepatic fibrosis, portal hemodynamic changes, and disease severity in patients with HCV-related liver cirrhosis after sustained virologic response to direct-acting antiviral drugs (DAAs) Egypt. Liver J. Pub Date : 2023-10-02 Waleed Attia Hassan, Sherif I. Kamel, Ibrahim Abdel Naby Mahmoud, Nahed Makhlouf, Mahmoud Moubark, Sahar M. Hassany
Regression of fibrosis and improvement of portal hemodynamics after achievement of sustained viral response (SVR) in patients with chronic hepatitis C (HCV) is a subject of debate in different studies. Some studies reported improvement in the degree of fibrosis, while others did not find significant changes. We aimed to evaluate changes in liver fibrosis, portal hemodynamics and clinical outcomes in
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Liver function test (SGPT) abnormality in 319 confirmed COVID-19 cases in Bangladesh Egypt. Liver J. Pub Date : 2023-09-28 Mahbuba Yesmin, Nirmol Kumar Biswas, Afroja Alam
Deranged liver function abnormalities are well-recognized sequela of COVID-19 infection. Globally, there are studies dedicated to evaluate spectrum of liver injury by COVID-19. In this study, we have described the impact of COVID-19 on liver function tests in 319 confirmed COVID cases in Bangladesh. Our study aimed to determine the liver function alteration by COVID-19 in our population. This study
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Lifestyle determinants as predictor of severity of metabolic associated fatty liver disease (MAFLD) Egypt. Liver J. Pub Date : 2023-09-19 Abeer Attia, Nargis Albert Labib, Noha Essameldin Elsayed Abdelzaher, Sherief Musa, Mira Atef
Metabolic-associated fatty liver disease (MAFLD) is a public health issue that can result in liver cirrhosis and its complications. Assess the dietary pattern, physical activity, and sleep quality of MAFLD patients. Cross-sectional study of 77 MAFLD patients being present in the outpatient clinic of Endemic Medicine Department at Cairo University Hospital. An interview questionnaire including sociodemographic
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Genotoxic effect of Tamiflu and Adamine on DNA content in male albino mice Egypt. Liver J. Pub Date : 2023-09-09 Nagla Zaky Ibrahim El-Alfy, Samia Mohamed Sakr, Mahmoud Fathy Mahmoud, Heba Ahmed Omar
Tamiflu (Oseltamivir) and Adamine (Amantadine HCl) are antiviral drugs which are used for prevention and treatment for influenza. The present study was carried out to evaluate the effect of Tamiflu and Adamine on DNA content of hepatocytes of adult male albino mice. The results of comet assay showed that treatment with Tamiflu and Adamine significantly increased (P < 0.005) the mean of DNA damage in
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Hepatic involvement in childhood dengue infection Egypt. Liver J. Pub Date : 2023-09-08 Rubaiyat Alam, Md. Rukunuzzaman, Khan Lamia Nahid
Dengue or breakbone fever is one of the most important causes of febrile illness in children residing in tropical and subtropical regions. This mosquito-borne viral disease is mediated by the bite of the infected Aedes mosquito. Dengue infection has been expanding rapidly throughout the globe in the past few decades. The virus has hepatotoxic effects. However, the pathophysiology of liver involvement
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Hepatic function and structure in feral pigeons (Columba livia domestica) exposed to zinc oxide nanoparticles Egypt. Liver J. Pub Date : 2023-09-04 Mehran Arabi, Hamid-Reza Naseri
Broad applications of nanoparticles have invoked the concerns about their impacts on living organisms. This study aimed to evaluate the possible changes that could take place in the liver of feral pigeons (Columba livia domestica) after oral ingestion of zinc oxide nanoparticles (nano-ZnO). Pigeons were acclimatized to the laboratory conditions with a photoperiod of 12:12 h at 20 ± 2 ˚C for 14 days
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Dyspnoea in liver cirrhosis: beyond the ordinary cardiopulmonary cause Egypt. Liver J. Pub Date : 2023-09-01 Yun Xiu Yong, Lee Yee Lim, Kuan Yee Lim
Dyspnoea is a common presentation to the casualties, attributed mostly to cardiopulmonary diseases. Approach to dyspnoea consists of initial acute management to ensure airway patency, respiratory support, and hemodynamic stability, followed by identification of the underlying disease for a definite management to reduce short-term inpatient morbidity and mortality, and rehospitalization in long term
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Association between Asia–Pacific body mass index classification and serum liver enzymes: alanine aminotransferase, aspartate aminotransferase and gamma-glutamyl transferase in healthy individuals Egypt. Liver J. Pub Date : 2023-08-22 Epitagama Liyana Arachchige Navoda Navanjalee Dilhara, Kosgahagoda Durage Chandika Pushpakumara, Pathiranage Dias, Athapaththu Mudiyanselage Buddhika Priyadarshani
Elevated levels of serum liver transaminases are good indicators of liver cell damage, and elevated serum gamma-glutamyl transferase (GGT) level is a good indicator of both bile duct and hepatocellular damage. At early stages, elevated serum levels of these liver enzymes can be mostly prevailed as an asymptomatic condition and therefore in an undiagnosed state. This may be resulted in a number of complications
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Hepatic artery infusion chemotherapy for advanced hepatocellular carcinoma Egypt. Liver J. Pub Date : 2023-08-10 Mohamed Houseni, Mahmoud Abdel Aziz Abdel Hady, Sameh Abokoura
One of the most common malignant neoplasms in humans is hepatocellular carcinoma (HCC). The development of HCC is thought to be significantly related to chronic hepatitis B virus or hepatitis C virus infection, ingesting food contaminated with aflatoxin B1, and alcohol use [1]. The portal vein is susceptible to being invaded by the tumour, leading to portal vein tumour thrombosis (PVTT) [2]. The most
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Performance of Albumin-Bilirubin (ALBI) score in comparison to other non-invasive markers in the staging of liver fibrosis in chronic HCV patients Egypt. Liver J. Pub Date : 2023-08-05 Mohamed B. Hashem, Shereen Abdel Alem, Aisha Elsharkawy, Rabab Fouad, Gamal Esmat, Zeinab Abdellatif
The prognostic ability of albumin-bilirubin score (ALBI) to assess the hepatic dysfunction in patients with hepatocellular carcinoma (HCC) was previously studied. Its role in the staging of liver fibrosis post chronic hepatitis C Virus (HCV) infection needs to be investigated. to assess the diagnostic value of the ALBI score compared to other non-invasive fibrosis scores in chronic HCV patients. This
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The “dark” side of terlipressin: a case report of ischemic skin necrosis and review of literature Egypt. Liver J. Pub Date : 2023-07-27 Arpit Shastri, Sweta Rose, Nikhil Vojjala, Naveen Bhagat, Arka De
Terlipressin is a commonly used drug in cirrhotic patients with acute variceal bleed (AVB) due to its vasoconstrictor effects. Ischemic complications are uncommon adverse events associated with worse outcomes. We present a case of alcohol-related cirrhosis, who was started on terlipressin for AVB. However, he developed bilateral lower limb gangrene with ischemic skin necrosis and ultimately succumbed
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Prognostic factors determining the surgical interference of biliary atresia in Egyptian infants: single-center experience Egypt. Liver J. Pub Date : 2023-07-18 Samira A. Abdel-Aziz, Mohamed Taha, Mohamed Balabel, Osama Hegazy, Esam Salah, Mervat Soltan, Marowa A. Tahoon, Gihan A. Sobhy
Biliary atresia is associated with considerable morbidity, and it is the most frequent indication for pediatric liver transplantation. Hepatic portoentostomy (HPE), Kasai procedure, is used commonly as the first line of treatment but its long-term efficacy still remains controversial. In this study we decided to illustrate most of the perioperative clinical, biomarkers, histopathological, and surgical
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Liver stiffness, hepatorenal index, and microRNA-130b as predictors for chronic kidney disease in patients with non-alcoholic fatty liver disease Egypt. Liver J. Pub Date : 2023-07-15 Mohamed Yosef El Hassafy, Abeer Shawky Elhadidi, Mona Mostafa Tahoon, Eman El-Dawi Hemimi, Sameh Aldesoky Lashen
Currently, nonalcoholic liver disease (NAFLD) is the most predominant chronic liver disorder. NAFLD has been linked to hepatic and extrahepatic morbidities. We aimed to investigate the role of acoustic radiation force impulse (ARFI), hepatorenal index (HRI), and serum microRNA-130b as non-invasive predictors for chronic kidney disease (CKD) in NAFLD patients. In a case–control design, we included 40
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Laparoscopic Roux-en-Y hepaticojejunostomy as an acute treatment of a right posterior hepatic duct injury: a case report Egypt. Liver J. Pub Date : 2023-07-11 Jose Agustin Rodriguez Zamboni, Paloma Ruiz Diaz, Maria Elena Peña, Fernando Iglesia, Guillermo Pfaffen
Laparoscopic cholecystectomy (LC) remains as the gold standard of surgical treatment for gallstone disease. Biliary duct injury (BDI) is an infrequent but serious complication of LC. Strasberg's critical view is a useful strategy to minimize the risk of a BDI. However, BDIs could still happen. Variations of the right posterior hepatic duct (RPHD) are common. The surgical treatment of RPHD injury is