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Novel findings in a Swedish primary familial brain calcification cohort J. Neurol. Sci. (IF 4.4) Pub Date : 2024-04-18 Stefan Sennfält, Peter Gustavsson, Helena Malmgren, Eric Gilland, Håkan Almqvist, Mikael Oscarson, Martin Engvall, Ingemar Björkhem, Daniel Nilsson, Kristina Lagerstedt-Robinson, Per Svenningsson, Martin Paucar
Brain calcifications are frequent findings on imaging. In a small proportion of cases, these calcifications are associated with pathogenic gene variants, hence termed primary familial brain calcification (PFBC). The clinical penetrance is incomplete and phenotypic variability is substantial. This paper aims to characterize a Swedish PFBC cohort including 25 patients: 20 from seven families and five
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Emotion recognition in amyotrophic lateral sclerosis in a dynamic environment J. Neurol. Sci. (IF 4.4) Pub Date : 2024-04-16 Marco Ceccanti, Laura Libonati, Federica Moret, Edoardo D'Andrea, Maria Cristina Gori, Francesco Saverio Bersani, Maurizio Inghilleri, Chiara Cambieri
The aim of our study was to measure the ability of ALS patients to process dynamic facial expressions as compared to a control group of healthy subjects and to correlate this ability in ALS patients with neuropsychological, clinical and neurological measures of the disease. Sixty-three ALS patients and 47 healthy controls were recruited. All the ALS patients also underwent i) the Geneva Emotion Recognition
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Adalimumab as treatment for neurosarcoidosis: A case series J. Neurol. Sci. (IF 4.4) Pub Date : 2024-04-16 Jeffrey Shen, Megumi Sugita, Andrea Linares-Lopez, Suma Shah, Christopher Eckstein, Elijah Lackey
Sarcoidosis is a disease characterized by non-caseating granulomas that can involve the central nervous system as neurosarcoidosis. This challenging disease is currently managed with high dose steroids, and sometimes the addition of infliximab. Other TNA-alpha inhibitors have not been studied as rigorously. We discovered ten neurosarcoidosis patients who were on an alternative TNA-alpha inhibitor,
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Ten-year fracture risk in Japanese patients with myasthenia gravis: A comprehensive assessment using the fracture risk assessment tool J. Neurol. Sci. (IF 4.4) Pub Date : 2024-04-16 Shingo Konno, Takafumi Uchi, Hideo Kihara, Hideki Sugimoto
Myasthenia gravis (MG) is an immune disorder that causes muscle weakness with an increasing prevalence, particularly among the elderly in Japan. Glucocorticoid treatment for MG is problematic for bone health because of reduced bone density and increased fracture risk. The fracture risk assessment tool (FRAX®) can estimate fracture risk, but its applicability in patients with MG remains uncertain. A
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Serum neurofilament light chain, inflammatory markers, and kynurenine metabolites in patients with persistent post-concussion symptoms: A cohort study J. Neurol. Sci. (IF 4.4) Pub Date : 2024-04-15 Peter Preben Eggertsen, Johan Palmfeldt, Asger Roer Pedersen, Oana-Veronica Frederiksen, Rikke Katrine Jentoft Olsen, Jørgen Feldbæk Nielsen
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The search for blood-biomarkers of persistent post-concussion symptoms J. Neurol. Sci. (IF 4.4) Pub Date : 2024-04-13 Timothy B. Meier
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Clinical and genetic features of dominant Essential Tremor in Tuscany, Italy: FUS, CAMTA1, ATXN1 and beyond J. Neurol. Sci. (IF 4.4) Pub Date : 2024-04-13 D. Orsucci, A. Tessa, E. Caldarazzo Ienco, R. Trovato, G. Natale, G. Bilancieri, M. Giuntini, A. Napolitano, S. Salvetti, M. Vista, F.M. Santorelli
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Use of the concussion check protocol for concussion assessment in a female soccer team over two consecutive seasons in New Zealand J. Neurol. Sci. (IF 4.4) Pub Date : 2024-04-13 Doug King, Patria Hume, Trevor Clark, Jennifer Wethe
Address deficiencies in access to sports sideline medical care by using a Concussion Check Protocol (CCP) for non-medically-trained people. A prospective observational cohort study was undertaken on a single amateur female club-based soccer team over two consecutive years in New Zealand utilising a non-medically trained support person termed a Safety officer. CCP is an extension of the King-Devick
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Endovascular thrombectomy for large ischemic strokes: An updated living systematic review and meta-analysis of randomized clinical trials J. Neurol. Sci. (IF 4.4) Pub Date : 2024-04-09 Rami Z. Morsi, Mohamed Elfil, Hazem S. Ghaith, Mohammad Aladawi, Ahmed Elmashad, Sachin Kothari, Harsh Desai, Sherief Ghozy, Shyam Prabhakaran, Krishna Amuluru, Chirag D. Gandhi, Tareq Kass-Hout, Fawaz Al-Mufti
Recent studies indicate endovascular thrombectomy (EVT) as a safe, effective treatment for acute ischemic stroke (AIS) with large ischemic regions. Our study updates an ongoing living systematic review and meta-analysis of randomized controlled trials (RCTs) comparing outcomes of EVT to medical management only. We searched MEDLINE, EMBASE, and the Cochrane Library for RCTs comparing EVT to medical
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Favorable prognosis in posterior circulation ischemic stroke: Insights from a nationwide stroke databank J. Neurol. Sci. (IF 4.4) Pub Date : 2024-04-09 Masaomi Koyanagi, Taketo Hatano, Michikazu Nakai, Takenori Ogura, Kazuo Minematsu, Shotai Kobayashi, Kazunori Toyoda, for the Japan Stroke Data Bank Investigators
Clinical trials have historically underrepresented patients with posterior circulation ischemic stroke (PCIS). This study aimed to comprehensively assess the clinical characteristics and outcomes of PCIS patients compared to those with anterior circulation ischemic stroke (ACIS). A retrospective analysis was conducted using data from the Japan Stroke Data Bank, encompassing 20 years across 130 stroke
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Data-driven subtypes of mixed semantic-logopenic primary progressive aphasia: Linguistic features, biomarker profiles and brain metabolic patterns J. Neurol. Sci. (IF 4.4) Pub Date : 2024-04-06 Salvatore Mazzeo, Carmen Morinelli, Cristina Polito, Giulia Giacomucci, Valentina Moschini, Assunta Ingannato, Juri Balestrini, Daniele Frigerio, Filippo Emiliani, Giulia Galdo, Chiara Crucitti, Diletta Piazzesi, Silvia Bagnoli, Sonia Padiglioni, Valentina Berti, Sandro Sorbi, Benedetta Nacmias, Valentina Bessi
Mixed primary progressive aphasia (mPPA) accounts for a substantial proportion of primary progressive aphasia (PPA) cases. However, the lack of a standardised definition of this condition has resulted in misclassification of PPA cases. In this study, we enrolled 55 patients diagnosed with PPA, comprising 12 semantic variant (svPPA), 23 logopenic variant (lvPPA), and 20 mPPA cases with linguistic characteristics
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Are physical activity levels, cardiorespiratory fitness and peak power associated with Parkinson's disease severity? J. Neurol. Sci. (IF 4.4) Pub Date : 2024-04-05 Frederik Bonde-Jensen, Ulrik Dalgas, Martin Langeskov-Christensen
Increased physical activity (PA) may slow Parkinson's disease (PD) progression. Associations between markers of PA and PD severity could justify further studies evaluating interventions increasing PA levels in PD. The objectives of the present study were to assess associations between PA, cardiorespiratory fitness (VO-max), and muscle peak power and measures of the Movement Disorder Society-sponsored
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Trends from two decades of orphan designations in paediatric rare neuromuscular diseases J. Neurol. Sci. (IF 4.4) Pub Date : 2024-04-03 Dinah M. Duarte, Maria Beatriz da Silva Lima, Bruno Sepodes
Rare diseases are characterized by substantial unmet need mostly because the majority have limited, or no treatment options and a large number also affect children. Since the inception of EU orphan regulation in 2000 the European Medicines Agency Committee for Orphan Medicinal Products has received several applications for paediatric rare neuromuscular diseases (PERAN) however treatment options remain
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Successful treatment of cranial dystonia using a Zolpidem+Melatonin combination: A video case-series J. Neurol. Sci. (IF 4.4) Pub Date : 2024-04-03 Narendrakumar H. Barad, Eoin Mulroy
Cranial dystonias (CrD) are challenging to treat. Oral pharmacotherapy is often sub-optimal, while delicate anatomy and limited availability of skilled botulinum toxin injectors makes this approach risky, and often difficult to access; neurosurgical options e.g. deep brain stimulation, are high-risk in the elderly populations most affected. Six patients were treated with Zolpidem+Melatonin. Pre- and
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Neuronal intranuclear inclusion disease in New Zealand: A novel discovery J. Neurol. Sci. (IF 4.4) Pub Date : 2024-04-03 Tony Zhang, Andrew Chancellor, Bernard Liem, Clinton Turner, David Hutchinson, Edward Wong, Emma Glamuzina, Jae Beom Hong, James Cleland, Nicholas Child, Richard H. Roxburgh, Shilpan Patel, Yi-Chung Lee, Yi-Chu Liao, Neil E. Anderson
Neuronal intranuclear inclusion disease, caused by a GGC repeat expansion in the 5′-untranslated region of , is a rare neurodegenerative condition with highly variable clinical manifestations. In recent years, the number of reported cases have increased dramatically in East Asia. We report the first four genetically confirmed cases of neuronal intranuclear inclusion disease in New Zealand, all having
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Diagnostic value of lower extremity ultrasonographic nerve enlargement for differentiating demyelinating Charcot-Marie-Tooth disease from chronic inflammatory demyelinating polyneuropathy J. Neurol. Sci. (IF 4.4) Pub Date : 2024-04-02 Hiroyuki Naito, Takamichi Sugimoto, Akemi Hironaka, Masahiro Nakamori, Yu Yamazaki, Kazuhide Ochi, Hirofumi Maruyama
We previously reported that nerve enlargement assessment by nerve ultrasonography of the intermediate upper limb is applicable for distinguishing demyelinating Charcot-Marie-Tooth disease (CMT) from chronic inflammatory demyelinating polyneuropathy (CIDP). However, differences in the severity and distribution patterns of lower extremity nerve enlargement have not been established for either disease
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Predicting post-surgical outcomes in idiopathic normal pressure hydrocephalus using clinically important changes from the cerebrospinal fluid tap test J. Neurol. Sci. (IF 4.4) Pub Date : 2024-04-02 Ryan M. Gallagher, Jodie L. Marquez, Shabnam Dal, Peter G. Osmotherly
Patients diagnosed with idiopathic Normal Pressure Hydrocephalus (iNPH) typically experience symptom improvements after undergoing a cerebrospinal fluid-tap test (CSF-TT), These improvements are recognized as indicative of potential improvements following surgical intervention. As gait disturbance is the most common iNPH symptom, gait improvements are of predominant interest. The purpose of this study
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Psilocybin pulse regimen reduces cluster headache attack frequency in the blinded extension phase of a randomized controlled trial J. Neurol. Sci. (IF 4.4) Pub Date : 2024-04-02 Emmanuelle A.D. Schindler, R. Andrew Sewell, Christopher H. Gottschalk, L. Taylor Flynn, Yutong Zhu, Brian P. Pittman, Nicholas V. Cozzi, Deepak C. D'Souza
In a recent randomized, double-blind, placebo-controlled study, we observed a nonsignificant reduction of attack frequency in cluster headache after pulse administration of psilocybin (10 mg/70 kg, 3 doses, 5 days apart each). We carried out a blinded extension phase to consider the safety and efficacy of repeating the pulse regimen. Eligible participants returned to receive a psilocybin pulse at least
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Hypothalamic involvement in multiple system atrophy: A structural MRI study J. Neurol. Sci. (IF 4.4) Pub Date : 2024-04-02 Jacopo Pasquini, Michael J. Firbank, Laura Best, Victoria Foster, Debra Galley, Vincenzo Silani, Roberto Ceravolo, George Petrides, David J. Brooks, Kirstie N. Anderson, Nicola Pavese
To investigate hypothalamic atrophy and its clinical correlates in multiple system atrophy (MSA) in-vivo. MSA is characterized by autonomic dysfunction and parkinsonian/cerebellar manifestations. The hypothalamus regulates autonomic and homeostatic functions and is also involved in memory and learning processes. 11 MSA, 18 Parkinson's Disease (PD) and 18 Healthy Controls (HC) were included in this
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Sex differences in treatment effect in neuroprotectant trials for acute ischemic stroke: A systematic review J. Neurol. Sci. (IF 4.4) Pub Date : 2024-04-02 Sahily Reyes-Esteves, Donna K. George, Brett Cucchiara
Pre-clinical data suggest sex differences in mechanisms of cerebral ischemic injury. This might result in differential outcomes of putative neuroprotectants by sex, though little systematic data is available to assess this. We performed a systematic review of multicenter randomized controlled trials published from January 1980–June 2022 enrolling >100 subjects and testing neuroprotectants in acute
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A systematic review of randomized controlled trials of endovascular therapy for stroke on mortality and disability J. Neurol. Sci. (IF 4.4) Pub Date : 2024-04-02 Kazutaka Uchida, Leon A. Rinkel, Johanna M. Ospel, William K. Diprose, Mayank Goyal
Endovascular treatment (EVT) has become standard of care for patients with anterior circulation large vessel occlusion (LVO) stroke, with indications having recently expanded to late time-window and large ischemic core patients. There is conflicting evidence on whether EVT reduces mortality or only disability. We performed a meta-analysis of randomized controlled trials (RCTs) to assess the effect
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Bilateral vestibulopathy as the initial presentation of CANVAS J. Neurol. Sci. (IF 4.4) Pub Date : 2024-04-02 Carlos R. Gordon, Roy Zaltzman, Dario Geisinger, Zohar Elyoseph, Yoav Gimmon
Cerebellar ataxia with neuropathy and vestibular areflexia syndrome (CANVAS) is a slowly progressing autosomal recessive ataxic disorder linked to an abnormal biallelic intronic (most commonly) AAGGG repeat expansion in the replication factor complex subunit 1 (RFC1). While the clinical diagnosis is relatively straightforward when the three components of the disorder are present, it becomes challenging
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Pathogenesis and management of low-pressure hydrocephalus: A narrative review J. Neurol. Sci. (IF 4.4) Pub Date : 2024-04-02 Shanshan Duan, Jin Hu
Patients diagnosed with low-pressure hydrocephalus typically present with enlarged ventricles and unusually low intracranial pressure, often measuring below 5 cmHO or even below atmospheric pressure. This atypical presentation often leads to low recognition and diagnostic rates. The development of low-pressure hydrocephalus is believed to be associated with a decrease in the viscoelasticity of brain
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Nerve ultrasound aids sural nerve biopsy in sarcoid neuropathy J. Neurol. Sci. (IF 4.4) Pub Date : 2024-04-01 Amuro Kondo, Keiichi Hokkoku, Taiji Mukai, Yudai Uchida, Takashi Chiba, Asuka Kitamura, Akatsuki Kubota, Yuki Hatanaka, Masahiro Sonoo, Jun Shimizu, Shunsuke Kobayashi
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Delayed levodopa-responsive parkinsonism following acute midbrain injury J. Neurol. Sci. (IF 4.4) Pub Date : 2024-04-01 Tali Friedman-Korn, Caroline Weill, Simona Ben-Haim, David Arkadir
Acute midbrain injury may cause both hyperkinetic movement disorders and parkinsonism. The temporal interval between the insult and the emergence of hyperkinetic disorders can last years. A delayed appearance of parkinsonism, on the other hand, was rarely described. We present three cases of male patients (50-, 58- and 28-year-old) who developed levodopa-responsive parkinsonism 20, 8 and two years
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Cerebrospinal fluid glial fibrillary acidic protein, in contrast to amyloid beta protein, is associated with disease symptoms in Huntington's disease J. Neurol. Sci. (IF 4.4) Pub Date : 2024-03-30 Sara Korpela, Jimmy Sundblom, Henrik Zetterberg, Radu Constantinescu, Per Svenningsson, Martin Paucar, Valter Niemelä
Huntington's disease (HD) is a hereditary neurodegenerative disease, currently lacking disease-modifying treatments. Biomarkers are needed for objective assessment of disease progression. Evidence supports both complex protein aggregation and astrocyte activation in HD. This study assesses the 42 amino acid long amyloid beta (Aβ42) and glial fibrillary acidic protein (GFAP) as potential biomarkers
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Long-term cognitive and neurovascular changes after carotid endarterectomy J. Neurol. Sci. (IF 4.4) Pub Date : 2024-03-28 Kristiina Relander, Marja Hietanen, Petra Ijäs, Krista Nuotio, Pirkka Vikatmaa, Suvi M. Koskinen, Marianne Ala-Kauhaluoma, Teemu I. Paajanen, Jussi Virkkala, Perttu J. Lindsberg, Lauri Soinne
Carotid endarterectomy (CEA) has been associated with both cognitive decline and improvement, but the underlying neurovascular mechanisms are unclear. The aim of this study was to investigate the relationship between neurovascular indices and cognitive changes after CEA. We studied 55 patients with severe (≥70%) symptomatic or asymptomatic carotid stenosis before and six months after CEA. A wide array
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Continuing the search for fluid biomarkers to enhance Huntington's disease staging and therapeutic response J. Neurol. Sci. (IF 4.4) Pub Date : 2024-03-27 Eilrayna Gelyana, Rebecca Khamishon, Jee Bang
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Early neurological changes following endovascular therapy for acute stroke due to intracranial atherosclerotic disease J. Neurol. Sci. (IF 4.4) Pub Date : 2024-03-26 Kazutaka Uchida, Hiroshi Yamagami, Nobuyuki Sakai, Koji Iihara, Hirotoshi Imamura, Akira Ishii, Yuji Matsumaru, Chiaki Sakai, Tetsu Satow, Fumihiro Sakakibara, Manabu Shirakawa, Shinichi Yoshimura, The JR-NET4 Study Group
Endovascular therapy (EVT) reduces functional disability in patients with acute large vessel occlusion (LVO). However, the early neurological change after EVT may be limited in patients with intracranial atherosclerotic disease (ICAD). We analyzed the Japanese Registry of NeuroEndovascular Therapy (JR-NET) 4 which was a retrospective, nationwide, multicenter registry of patients with LVO between 2015
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Primary headache disorders among people living with HIV in Lusaka, Zambia J. Neurol. Sci. (IF 4.4) Pub Date : 2024-03-21 Curi Kim, Mashina Chomba, Arnold Phiri, Sombo Fwoloshi, Cassidy W. Claassen, Lottie Hachaambwa, Deanna Saylor
We completed a cross-sectional survey study to determine headache prevalence and its association with HIV characteristics among people living with HIV (PLHIV) in Lusaka, Zambia. Headaches are common but their association with HIV status is unknown. The HARDSHIP survey, a headache epidemiology questionnaire previously validated in Zambia, was distributed during a 3-month period to 3666 consecutive adult
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Superficial small cerebellar infarcts in cerebral amyloid angiopathy on 3 T MRI: A preliminary study J. Neurol. Sci. (IF 4.4) Pub Date : 2024-03-21 Yuichiro Ii, Hidehiro Ishikawa, Akisato Nishigaki, Takaya Utsunomiya, Naoko Nakamura, Yoshinori Hirata, Hirofumi Matsuyama, Hiroyuki Kajikawa, Keita Matsuura, Kana Matsuda, Masaki Shinohara, Seiya Kishi, Ryota Kogue, Maki Umino, Masayuki Maeda, Hidekazu Tomimoto, Akihiro Shindo
Strictly superficial cerebellar microbleeds and cerebellar superficial siderosis have been considered markers of advanced cerebral amyloid angiopathy (CAA), but there are few studies on cerebellar ischemic lesions in CAA. We investigated the presence of superficial small cerebellar infarct (SCI) ≤15 mm and its relation to magnetic resonance imaging (MRI) markers in patients with probable CAA. Eighty
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Spinocerebellar ataxia type 4 is not detected in a cohort from Hokkaido, the northernmost island of Japan J. Neurol. Sci. (IF 4.4) Pub Date : 2024-03-20 Shinichi Shirai, Keiichi Mizushima, Yuka Shibata, Masaaki Matsushima, Ikuko Iwata, Hiroaki Yaguchi, Ichiro Yabe
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The role of genetics in the treatment of dystonia with deep brain stimulation: Systematic review and Meta-analysis J. Neurol. Sci. (IF 4.4) Pub Date : 2024-03-20 Harini Sarva, Federico Rodriguez-Porcel, Francisco Rivera, Claudio Daniel Gonzalez, Samantha Barkan, Susmit Tripathi, Emilia Gatto, Pedro Garcia Ruiz, Rare Movement Disorders Study Group of the International Parkinsons and Movement Disorders Society
Dystonia is a movement disorder characterized by sustained or intermittent muscle contractions that lead to involuntary postures or repetitive movements. Genetic mutations are being increasingly recognized as a cause of dystonia. Deep brain stimulation (DBS) is one of the limited treatment options available. However, there are varying reports on its efficacy in genetic dystonias. This systematic review
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HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP): Case based discussion of risk factors, clinical, and therapeutic considerations J. Neurol. Sci. (IF 4.4) Pub Date : 2024-03-19 Lea Saab, Daniel DiCapua, Adeel S. Zubair
HTLV-1 is a retrovirus virus that infects CD4+ T cells. Most people with HTLV-1 infection remain asymptomatic but some may develop conditions such as HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) or adult T-cell leukemia/lymphoma. HAM/TSP is characterized by progressive spasticity and weakness of the lower extremities, as well as loss of bladder control and sensory disturbances
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Timing initiation of non-invasive ventilation in management of ALS J. Neurol. Sci. (IF 4.4) Pub Date : 2024-03-19 Michael Swash
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Remote pulmonary function testing allows for early identification of need for non-invasive ventilation in a subset of persons with ALS J. Neurol. Sci. (IF 4.4) Pub Date : 2024-03-19 Andrew Geronimo, Zachary Simmons
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Stroke occurrence by hypertension treatment status in Ghana and Nigeria: A case-control study J. Neurol. Sci. (IF 4.4) Pub Date : 2024-03-17 Fred Stephen Sarfo, Osahon Jeffery Asowata, Onoja Matthew Akpa, Joshua Akinyemi, Kolawole Wahab, Arti Singh, Albert Akpalu, Priscilla Abrafi Opare-Addo, Akinkunmi Paul Okekunle, Godwin Ogbole, Adekunle Fakunle, Oladimeji Adebayo, Reginald Obiako, Cynthia Akisanya, Morenkeji Komolafe, Taiwo Olunuga, Innocent I. Chukwuonye, Godwin Osaigbovo, Paul Olowoyo, Phillip B. Adebayo, Carolyn Jenkins, Abiodun
Hypertension is preeminent among the vascular risk factors for stroke occurrence. The wide gaps in awareness, detection, treatment, and control rates of hypertension are fueling an epidemic of stroke in sub-Saharan Africa. To quantify the contribution of untreated, treated but uncontrolled, and controlled hypertension to stroke occurrence in Ghana and Nigeria. The Stroke Investigative Research and
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Differential diagnosis between multiple sclerosis and leukodystrophies – A scoping review J. Neurol. Sci. (IF 4.4) Pub Date : 2024-03-16 Luis Eduardo Ramos Chaer, Jakeline Martins de Mendonça, Maria Cristina del Negro, Ricardo Titze-de-Almeida, Nícolas Philippe Balduino Nogueira, Priscila Mara Provetti, Pedro Renato de Paula Brandão, Diógenes Diego de Carvalho Bispo, Gabriela Billafan Ferreira, Ingrid Faber, Taina Barreto Cavalcante, Tarso Adoni, Juliana F. Mazzeu, Felipe von Glehn
Multiple Sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS) characterized by damage to the myelin sheaths of oligodendrocytes. Currently, there is no specific biomarker to identify the disease; however, a diagnostic criterion has been established based on patient's clinical, laboratory, and imaging characteristics, which assists in identifying this condition.
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A case series of post-infectious chikungunya myeloradiculoneuropathy J. Neurol. Sci. (IF 4.4) Pub Date : 2024-03-14 Suresh Selvam, Padma Youron, Harpreet Singh, Ritu Shree, Vikas Suri, Manoj Goyal, Manish Modi, Ashish Bhalla
Chikungunya fever is an arboviral illness caused by chikungunya virus (CHIKV) and transmitted by the bite of and . It is an RNA virus belonging to the genus Alphavirus and family Togaviridae. We present a case series of three patients with chikungunya illness developing para/post-infectious myeloradiculoneuropathy.These patients developed neurological symptoms in the form of bilateral lower limb weakness
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Diagnostic value of vietnamese smell identification test in Parkinson's disease J. Neurol. Sci. (IF 4.4) Pub Date : 2024-03-12 Thuong Huyen Thi Dang, Tai Ngoc Tran, Frank Xing, Uyen Le Ngoc Ha, Khang Chung Ngoc Vo, Thanh Vinh Nguyen, Khang Vinh Nguyen, Hien Thi Le, Daniel Truong
The Vietnamese Smell Identification Test (VSIT) has been validated in determining olfactory dysfunction in the Vietnamese population; however, its value in diagnosing Parkinson's disease (PD) has not been established. This case-control study was conducted at University Medical Center HCMC, Ho Chi Minh City, Vietnam. The study sample included non-demented PD patients and healthy controls (HC) who were
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Technical and clinical outcomes of thrombectomy in patients with acute medium vessel occlusion and large vessel occlusion; sub-analyses of Japan Trevo registry J. Neurol. Sci. (IF 4.4) Pub Date : 2024-03-12 Shuntaro Kuwahara, Kazutaka Uchida, Nobuyuki Sakai, Hiroshi Yamagami, Hirotoshi Imamura, Masataka Takeuchi, Manabu Shirakawa, Fumihiro Sakakibara, Koichi Haraguchi, Naoto Kimura, Kentaro Suzuki, Shinichi Yoshimura, Japan Trevo Registry Investigators
Little is known about endovascular therapy (EVT) for patients with medium vessel occlusion (MeVO) and more work is needed to establish its efficacy and to understand hemorrhagic complications. We analyzed the Japan Trevo Registry, which enrolled patients with acute stroke who underwent EVT using Trevo Retriever alone or in combination with an aspiration catheter. The primary outcome was effective reperfusion
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Chronic inflammatory demyelinating polyneuropathy and HEV antibody status: A case-control study from Lazio, Italy J. Neurol. Sci. (IF 4.4) Pub Date : 2024-03-12 Federica Moret, Enea Spada, Marco Ceccanti, Laura Libonati, Edoardo D'Andrea, Umbertina Villano, Elisabetta Madonna, Paola Chionne, Alberto Carocci, Giulio Pisani, Laura Fionda, Giovanni Antonini, Antonio Petrucci, Roberto Bruni, Anna Rita Ciccaglione, Gloria Taliani, Marco Rivano Capparuccia, Eduardo Nobile-Orazio, Maurizio Inghilleri, Chiara Cambieri
Few studies have pointed to the possible role of infectious diseases in triggering Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP). Given the association of Hepatitis E Virus (HEV) with Guillain Barrè syndrome, we conducted a case-control study to determine the possible association of HEV infection with CIDP, analyzing possible risk factors for acquiring HEV infection in both CIDP
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A nationwide survey of facial onset sensory and motor neuronopathy in Japan J. Neurol. Sci. (IF 4.4) Pub Date : 2024-03-11 Senri Ko, Ryo Yamasaki, Tasuku Okui, Wataru Shiraishi, Mitsuru Watanabe, Yu Hashimoto, Yuko Kobayakawa, Susumu Kusunoki, Jun-ichi Kira, Noriko Isobe
The epidemiology and etiology of facial onset sensory and motor neuronopathy (FOSMN), a rare syndrome that initiates with facial sensory disturbances followed by bulbar symptoms, remain unknown. To estimate the prevalence of FOSMN in Japan and establish the characteristics of this disease, we conducted a nationwide epidemiological survey. In the primary survey, we received answers from 604 facilities
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Evaluation of prognostic scores for status epilepticus in the neurology ICU: A retrospective study J. Neurol. Sci. (IF 4.4) Pub Date : 2024-03-11 Jia Yi Shen, Seyed Ehsan Saffari, Linda Yong, Nigel Choon Kiat Tan, Yee-Leng Tan
Status epilepticus (SE) in the neurology intensive care unit (ICU) is associated with significant morbidity. We aimed to evaluate the utility of existing prognostic scores, namely the Status Epilepticus Severity Score (STESS), Epidemiology Based Mortality Score in Status Epilepticus (EMSE)-EACE and Encephalitis-Nonconvulsive Status Epilepticus-Diazepam Resistance-Image Abnormalities-Tracheal Intubation
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Long term quality of life follow-up and functional impairment study in patients with Hirayama disease J. Neurol. Sci. (IF 4.4) Pub Date : 2024-03-11 Adeel S. Zubair, Rafid Mustafa, Brian Crum
Hirayama Disease (HD) is a focal motor neuron disorder generally affecting young adults with a male predominance who experience weakness and atrophy in distal upper extremity muscles in an asymmetric or unilateral pattern. Progression is insidious though significant weakness occurs during a progressive phase of the disease over 2–5 years. The long-term outcome of HD is not as well-known and, thus,
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Diversity, equity, and inclusion (DEI) in medical education: DEI at the bedside J. Neurol. Sci. (IF 4.4) Pub Date : 2024-03-07 Tennyson S. Jellins, Tyler L. Borko, RayLee Otero-Bell, Kelly Arnett, Scott Saunders, Sharon N. Poisson, Karen D. Orjuela, Setareh Salehi Omran, William J. Jones, Michelle Leppert, Ashley Madera, Aaron Carlson, Daniel M. Pastula, Brian M. Sauer, Amanda L. Piquet, Nicole R. Gonzales
The ability to recognize and address bias is an important communication skill not typically addressed during training. We describe the design of an educational curriculum that aims to identify and change behavior related to diversity, equity, and inclusion (DEI). “DEI at the Bedside” uses the existing infrastructure of bedside teaching and provides a tool to normalize DEI discussions and develop skills
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Impact of dementia status on intravenous thrombolysis and endovascular treatment for acute ischemic stroke: Retrospective study J. Neurol. Sci. (IF 4.4) Pub Date : 2024-03-07 Jonathan Naftali, Gal Tsur, Eitan Auriel, Rani Barnea, Michael Findler, Guy Raphaeli, Ran Brauner, Keshet Pardo, Alain Perlow, Galit Weinstein, Penina Weiss, Amir Glik, Ophir Keret
Individuals with dementia are underrepresented in interventional studies for acute ischemic stroke (AIS). This research gap creates a bias against their treatment in clinical practice. Our goal was to compare the safety and efficacy of intravenous-thrombolysis (t-PA) and endovascular treatment (EVT) in individuals with or without pre-AIS dementia. A retrospective study of AIS patients receiving t-PA
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Efficacy and safety of ketamine for pediatric and adolescent super-refractory status epilepticus and the effect of cerebral inflammatory conditions J. Neurol. Sci. (IF 4.4) Pub Date : 2024-03-06 Ichiro Kuki, Takeshi Inoue, Masataka Fukuoka, Megumi Nukui, Hideo Okuno, Kiyoko Amo, Yasunori Otsuka, Junichi Ishikawa, Hiroshi Rinka, Atushi Ujiro, Masao Togawa, Masashi Shiomi, Shin Okazaki
To investigate the short-term benefits and adverse effects of ketamine in the treatment of pediatric and adolescent super-refractory status epilepticus (SRSE), with a focus on the inflammatory etiology. This retrospective observational cohort study included a consecutive series of 18 pediatric to adolescent patients with SRSE admitted between 2008 and 2023 and treated with ketamine. Seizure frequency
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Pearls and pitfalls in letters of recommendation for neurology residency applications J. Neurol. Sci. (IF 4.4) Pub Date : 2024-03-05 Ryka R. Sehgal, Harini Sarva, Joseph E. Safdieh, Matthew S. Robbins
Letters of recommendation are a cornerstone of residency applications. Variability and bias in letters exists across specialties, neurology being no exception. Studies done in other specialty fields assessing nuanced language uncovered key attention points for improvement and mitigation of bias, lessons from which should be applied in the field of neurology. We review common pearls and pitfalls in
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Taste and smell function in Wilson's disease J. Neurol. Sci. (IF 4.4) Pub Date : 2024-03-05 Mandy K. Salmon, William G. Cohen, Fengling Hu, Adem Aydin, Ayse K. Coskun, Michael Schilsky, Richard L. Doty
Wilson's disease (WD) is a metabolic disorder associated with abnormal copper metabolism that results in hepatic, psychiatric, and neurologic symptoms. No investigation of taste function has been made in patients with WD, although olfactory dysfunction has been evaluated. Quantitative taste and smell test scores of 29 WD patients were compared to those of 790 healthy controls. Taste was measured using
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Venous sinus stenting for idiopathic intracranial hypertension: An updated Meta-analysis J. Neurol. Sci. (IF 4.4) Pub Date : 2024-03-05 Ahmed Y. Azzam, Ali Mortezaei, Mahmoud M. Morsy, Muhammed Amir Essibayi, Sherief Ghozy, Osman Elamin, Mohammed A. Azab, Adam Elswedy, David Altschul, Ramanathan Kadirvel, Waleed Brinjikji, David F. Kallmes
Idiopathic intracranial hypertension (IIH) is characterized by elevated intracranial pressure and primarily affects obese women of reproductive age. Venous sinus stenting (VSS) is a surgical procedure used to treat IIH, but its safety and efficacy are still controversial. A systematic review and meta-analysis were conducted following PRISMA guidelines. Multiple databases were searched for studies evaluating
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A case of hereditary dementia: Is it Alzheimer's disease or not? J. Neurol. Sci. (IF 4.4) Pub Date : 2024-03-02 Chiara Giuseppina Bonomi, Matilde Bruno, Vito Luigi Colona, Mario Bengala, Alessandro Martorana
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Differing patterns of cortical grey matter pathology identified by multifractal analysis in UMN-predominant ALS patients with and without corticospinal tract hyperintensity J. Neurol. Sci. (IF 4.4) Pub Date : 2024-03-01 Venkateswaran Rajagopalan, Erik P. Pioro
The pathological hallmarks of amyotrophic lateral sclerosis (ALS) are degeneration of the primary motor cortex grey matter (GM) and corticospinal tract (CST) resulting in upper motor neuron (UMN) dysfunction. Conventional brain magnetic resonance imaging (MRI) shows abnormal CST hyperintensity in some UMN-predominant ALS patients (ALS-CST+) but not in others (ALS-CST–). In addition to the CST differences
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Retraction notice to Cerebrospinal fluid atypical lymphocytes in Japanese encephalitis” [JNS 160 (1998) 92–95] J. Neurol. Sci. (IF 4.4) Pub Date : 2024-02-29 Yoshihiro Sato, Naoki Hachiva, Haruko Kuno, Takeshi Asoh, Kotaro Oizumi
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The WFN Service page J. Neurol. Sci. (IF 4.4) Pub Date : 2024-02-29 Wolfgang Grisold, Steven L. Lewis
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Increased blood coagulation is associated with poor neurological outcome in aneurysmal subarachnoid hemorrhage J. Neurol. Sci. (IF 4.4) Pub Date : 2024-02-23 Essi Raatikainen, Heikki Kiiski, Anne Kuitunen, Eija Junttila, Heini Huhtala, Antti Kallonen, Marika Ala-Peijari, Jaakko Långsjö, Johanna Saukkonen, Timo Valo, Terhi Kauppila, Sanni Raerinne, Juhana Frösen, Annukka Vahtera
Patients with aneurysmal subarachnoid hemorrhage (aSAH) have demonstrated increased blood coagulation which is thought to contribute to delayed cerebral ischemia (DCI) and to a worse outcome. Therefore, we sought to determine whether this increased blood coagulation, detectable with rotational thromboelastometry (ROTEM), was associated with DCI and neurological outcome. We conducted a prospective observational
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Response to letter to the editor by Sterpetti et al J. Neurol. Sci. (IF 4.4) Pub Date : 2024-02-22 Jeroen Douwes, Mina Whyte, Annemarei Ranta
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Retraction notice to “Reply to Davie and Sharp: Different mechanisms of bone metabolism between patients with stroke and with spinal cord injury” [Journal of the Neurological Sciences 163 (1999) 100–101] J. Neurol. Sci. (IF 4.4) Pub Date : 2024-02-20 Yoshihiro Sato, Yukiko Fujimatsu, Munetsugu Kikuyama, Masahide Kaji, Kotaro Oizumi
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Retraction notice to “Histiocytic necrotizing lymphadenitis (Kikuchi's disease) with aseptic meningitis” [Journal of the Neurological Sciences 163 (1999) 187–191] J. Neurol. Sci. (IF 4.4) Pub Date : 2024-02-20 Yoshihiro Sato, Haruko Kuno, Kotaro Oizumi
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Retraction notice to “Rapid diagnosis of cryptococcal meningitis by microscopic examination of centrifuged cerebrospinal fluid sediment” [Journal of the Neurological Sciences 164 (1999) 72–75] J. Neurol. Sci. (IF 4.4) Pub Date : 2024-02-20 Yoshihiro Sato, Seishi Osabe, Haruko Kuno, Masahide Kaji, Kotaro Oizumi