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Corticospinal excitability during motor preparation of upper extremity reaches reflects flexor muscle synergies: A novel principal component-based motor evoked potential analyses Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2024-04-08 Thomas E. Augenstein, Seonga Oh, Trevor A. Norris, Joshua Mekler, Amit Sethi, Chandramouli Krishnan
Background: Previous research has shown that noninvasive brain stimulation can be used to study how the central nervous system (CNS) prepares the execution of a motor task. However, these previous studies have been limited to a single muscle or single degree of freedom movements (e.g., wrist flexion). It is currently unclear if the findings of these studies generalize to multi-joint movements involving
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EMG Testing throughout behavioral recovery after rat sciatic nerve crush injury results in exuberant motoneuron dendritic hypertrophy Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2024-02-15 Rena M. Meadows, Sarah M. E.V. Richards, Michelle R. Kitsis, Todd J. Brown, Kathy J. Jones, Dale R. Sengelaub
Background: Peripheral nerve injury (PNI) is the most common type of nerve trauma yet, while injured motoneurons exhibit a robust capacity for regeneration, behavioral recovery is protracted and typically poor. Neurotherapeutic approaches to PNI and repair have primarily focused on the enhancementof axonal regeneration, in terms of rate, axonal sprouting, and reconnection connectivity. Both electrical
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Comparative evaluation of rhFGF18 and rhGDF11 treatment in a transient ischemia stroke model Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2024-02-15 Alex Goraltchouk, Svetlana Mankovskaya, Tatjana Kuznetsova, Zhanna Hladkova, Judith M. Hollander, Francesco Luppino, Alexey Seregin
Background: Pharmacological treatments for ischemic stroke remain limited to thrombolysis, which is associated with increased risk of potentially fatal hemorrhage. Treatments with Recombinant Human Fibroblast Growth Factor 18 (rhFGF18) and Growth and Differentiation Factor 11 (rhGDF11) appear promising based on different preclinical models. The goal of this study was to compare the effects of rhFGF18
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Transcranial random noise stimulation to augment hand function in individuals with moderate-to-severe stroke: A pilot randomized clinical trial Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2024-01-30 Amit Sethi, Alvaro Pascual-Leone, Emiliano Santarnecchi, Ghaleb Almalki, Chandramouli Krishnan
Background:Interventions to recover upper extremity (UE) function after moderate-to-severe stroke are limited. Transcranial random noise stimulation (tRNS) is an emerging non-invasive technique to improve neuronal plasticity and may potentially augment functional outcomes when combined with existing interventions, such as functional electrical stimulation (FES). Objective:The objective of this study
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Long-term outcomes of plasma exchange versus intravenous immunoglobulin for the treatment of Guillain-Barré Syndrome: A double-blind, randomized clinical trial Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2024-01-11 Nourelhoda A. Haridy, Mohamed M. Shehab, Eman M. Khedr
Background: Most previous studies comparing the effectiveness of Plasma Exchange (PE) or intravenous immunoglobulin (IVIG) in treating Guillain-Barre syndrome (GBS) have focused on the short-term outcome at around 1 month. Objective: To compare the long-term efficacy of PE and IVIG at one year in adult patients with GBS. Methods: Eighty-one adult patients with acute GBS were randomized into two groups
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Shock waves modulate corticospinal excitability: A proof of concept for further rehabilitation purposes? Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2024-01-08 Matteo Guidetti, Anisa Naci, Andrea Cerri, Rossella Pagani, Antonino Michele Previtera, Alberto Priori, Tommaso Bocci
Background:Focal extracorporeal shock wave therapy (fESWT) is a physical therapy vastly studied and used for various musculoskeletal disorders. However, the effect of fESWT on central nervous system is still to be determined. Objective:To elucidate spinal and supra-spinal mechanisms of fESWT in healthy subjects, in order to widen the spectrum of its clinical applications. Methods:In this quasi-experimental
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Retinal ganglion cell and microvascular density loss in hereditary spastic paraplegia Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2024-01-06 Gabrielle N. Turski, Christopher A. Turski, Marcus Grobe-Einsler, Xenia Kobeleva, Jennifer S. Turski, Frank G. Holz, Robert P. Finger, Thomas Klockgether
Abstract Background: Hereditary spastic paraplegia (HSP) is characterized by progressive degeneration of distal axons in the long corticospinal tracts. Loss of retinal cells and microvascular networks has neither been suspected nor investigated. We concurrently examined the retinal microvasculature and retinal layer morphology in patients with HSP to assess whether retinal features may portray disease
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Targeted neurorehabilitation strategies in post-stroke aphasia Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2023-11-16 Priyanka Shah-Basak, Olga Boukrina, Xin Ran Li, Fatima Jebahi, Aneta Kielar
Abstract Background: Aphasia is a debilitating language impairment, affecting millions of people worldwide. About 40% of stroke survivors develop chronic aphasia, resulting in life-long disability. Objective: This review examines extrinsic and intrinsic neuromodulation techniques, aimed at enhancing the effects of speech and language therapies in stroke survivors with aphasia. Methods: We discuss the
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Integrating mind and body: Investigating differential activation of nodes of the default mode network Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2023-09-16 Inbal Linchevski, Amber Maimon, Yulia Golland, Noa Zeharia, Amir Amedi, Nava Levit-Binnun
Abstract Background: The default mode network (DMN) is a large-scale brain network tightly correlated with self and self-referential processing, activated by intrinsic tasks and deactivated by externally-directed tasks. Objective: In this study, we aim to investigate the novel approach of default mode activation during progressive muscle relaxation and examine whether differential activation patterns
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A novel digital approach for post-stroke cognitive deficits: a pilot study Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2023-07-24 Massimiliano Oliveri, Sergio Bagnato, Silvia Rizzo, Emilia Imbornone, Andreina Giustiniani, Angela Catania, Patrizia Turriziani
Background:Cognitive dysfunctions after a brain stroke have a huge impact on patients’ disability and activities of daily living. Prism adaptation (PA) is currently used in patients with right brain damage to improve lateralized spatial attentional deficits. Recent findings suggest that PA could also be useful for rehabilitation of other cognitive functions. Objective:In the present study, we tested
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Feasibility of using fNIRS to explore motor-related regional haemodynamic signal changes in patients with sensorimotor impairment and healthy controls: A pilot study Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2023-07-08 Lina Bunketorp Käll, Malin Björnsdotter, Johanna Wangdell, Carina Reinholdt, Robert Cooper, Simon Skau
Background:While functional near-infrared spectroscopy (fNIRS) can provide insight into cortical brain activity during motor tasks in healthy and diseased populations, the feasibility of using fNIRS to assess haemoglobin-evoked responses to reanimated upper limb motor function in patients with tetraplegia remains unknown. Objective:The primary objective of this pilot study is to determine the feasibility
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Restorative Neurology and Neuroscience: Celebrating the 40th volume of an academic journal Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2023-06-29 Bernhard A. Sabel
Abstract Since the first issue of the academic journal Restorative Neurology and Neuroscience (RNN) was published in 1989, 40 volumes with a total of 1550 SCI publications have helped advance basic and clinical sciences in the fields of central and peripheral nervous system rescue, regeneration, restoration and plasticity in experimental and clinical disorders. In this way RNN helped advance the development
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Analysis of hippocampus in rats with acute brain ischemia-reperfusion injury treated with leuprolide acetate, an agonist of GnRH Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2023-06-23 Rosario Montoya-García, Valeria Fernández-Vargas, Karla Nalini Albor-Martínez, Alicia Martínez-Martínez, Irma Hernández-Jasso, Andrés Quintanar-Stephano, Denisse Calderón-Vallejo, J. Luis Quintanar
Background:The hippocampus is highly vulnerable to damage in the brain ischemia-reperfusion injury model. Leuprolide acetate has been shown to promote neurological recovery after injury in various regions of the central nervous system. Objective:The objective of this study was to assess the histology of the hippocampus and the expression of neuronal recovery markers, specifically the 200 kDa neurofilaments
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Sensory augmentation for a rapid motor task in a multisensory environment Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2023-06-05 James Negen, Heather Slater, Marko Nardini
Abstract Background: Sensory substitution and augmentation systems (SSASy) seek to either replace or enhance existing sensory skills by providing a new route to access information about the world. Tests of such systems have largely been limited to untimed, unisensory tasks. Objective: To test the use of a SSASy for rapid, ballistic motor actions in a multisensory environment. Methods: Participants
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Retraction notice regarding several articles published in Restorative Neurology and Neuroscience. Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2022-01-01
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Effects of gait training on structural brain changes in Parkinson’s disease Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2023-04-10 Eunkyung Kim, Heejae Kim, Seo Jung Yun, Min-Gu Kang, Hyun Iee Shin, Byung-Mo Oh, Han Gil Seo
Background:Gait training may lead to functional brain changes in Parkinson’s disease (PD); however, there is a lack of studies investigating structural brain changes after gait training in PD. Objective:To investigate structural brain changes induced by 4 weeks of gait training in individuals withPD. Methods:Diffusion tensor imaging and structural T1 images were acquired in PD group before and after
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Cortical visual impairment at birth can be improved rapidly by vision training in adulthood: A case study Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2023-04-01 Ashim Pandey, Sujaya Neupane, Srijana Adhikary, Keepa Vaidya, Christopher C. Pack
Background:Cortical visual impairment (CVI) is a severe loss of visual function caused by damage to the visual cortex or its afferents, usually as a consequence of hypoxic insults during birth. It is one of the leading causes of vision loss in children, and it is most often permanent. Objective:Several studies have demonstrated limited vision restoration in adults who trained on well-controlled psychophysical
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Can brain stimulation enhance cognition in clinical populations? A critical review Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2022-11-11 Donel M. Martin, Marian E. Berryhill, Victoria Dielenberg
Many psychiatric and neurological conditions are associated with cognitive impairment for which there are very limited treatment options. Brain stimulation methodologies show promise as novel therapeutics and have cognitive effects. Electroconvulsive therapy (ECT), known more for its related transient adverse cognitive effects, can produce significant cognitive improvement in the weeks following acute
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The rehabilitation of object agnosia and prosopagnosia: A systematic review Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2022-09-23 Silvia Gobbo, Raffaella Calati, Maria Caterina Silveri, Elisa Pini, Roberta Daini
Background:Agnosia for objects is often overlooked in neuropsychology, especially with respect to rehabilitation. Prosopagnosia has been studied more extensively, yet there have been few attempts at training it. The lack of training protocols may partially be accounted for by their relatively low incidence and specificity to sensory modality. However, finding effective rehabilitations for such deficits
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Vision recovery with perceptual learning and non-invasive brain stimulation: Experimental set-ups and recent results, a review of the literature Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2022-08-06 Luca Battaglini, Michele Di Ponzio, Andrea Ghiani, Federica Mena, Paola Santacesaria, Clara Casco
Background:Vision is the sense which we rely on the most to interact with the environment and its integrity is fundamental for the quality of our life. However, around the globe, more than 1 billion people are affected by debilitating vision deficits. Therefore, finding a way to treat (or mitigate)them successfully is necessary. Objective:This narrative review aims to examine options for innovative
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Speech arrest by repetitive Transcranial Magnetic Stimulation – does it still work? Old experiences with new improvements Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2022-08-06 Martyna Borowczyk, Magdalena Wojtysiak, Anna Chmielarz-Czarnocińska, Małgorzata Braszka, Piotr Danielewski, Aleksandra Bryndal, Michał Michalak, Juliusz Huber
Background:Traditional repetitive Transcranial Magnetic Stimulation (rTMS) remains applicable in speech studies on healthy participants. Although the procedure of inducing speech arrest by rTMS has been used for over 25 years, there are still significant discrepancies in its methodology. Objective:The study aimed to simplify and improve the old methodology of triggering speech arrest by (rTMS). Our
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The assessment of biceps voluntary activation with transcranial magnetic stimulation in individuals with tetraplegia Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2022-07-15 Thibault Roumengous, Carrie L. Peterson
BACKGROUND:Assessment of voluntary activation is useful in the study of neuromuscular impairments, particularly after spinal cord injury (SCI). Measurement of voluntary activation with transcranial magnetic stimulation (VATMS) is limited by technical challenges, including the difficulty in preferential stimulation of cortical neurons projecting to the target muscle and minimal stimulation of antagonists
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The effect of mirror therapy can be improved by simultaneous robotic assistance Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2022-07-11 Mareike Schrader, Annette Sterr, Robyn Kettlitz, Anika Wohlmeiner, Rüdiger Buschfort, Christian Dohle, Stephan Bamborschke
Abstract Background: Standard mirror therapy (MT) is a well-established therapy regime for severe arm paresis after acquired brain injury. Bilateral robot-assisted mirror therapy (RMT) could be a solution to provide visual and somatosensory feedback simultaneously. Objective: The study compares the treatment effects of MT with a version of robotic-assisted MT where the affected arm movement was delivered
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Spin of information and inconsistency between abstract and full text in RCTs investigating upper limb rehabilitation after stroke: An overview study Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2022-06-14 Diego Tosatto, Daniele Bonacina, Alessio Signori, Leonardo Pellicciari, Francesca Cecchi, Cesare Maria Cornaggia, Daniele Piscitelli
Background:Researchers may be tempted to favorably distort the interpretation of their findings when reporting the abstract (i.e., spin). Spin bias overemphasizes the beneficial effects of the intervention compared with the results shown in the full text. Objective:To assess the occurrence of spinbias and incompleteness in reporting abstracts in post-stroke upper limb (UL) rehabilitation randomized
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Lateralized readiness potentials can identify hemisphere of recovery in stroke patients Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2022-05-23 Nevine El nahas, Tamer M. Roushdy, Hossam M. Shokri, Ramez R. Moustafa, Ahmed M. Elsayed, Randa M. Amin, Aya A. Ashour, Eman H. Abd Eldayem, Ghada A. Elhawary, Ahmed M. Elbokl
Highlights• In healthy adults, the lateralized readiness potential (LRP) is localized to the hemisphere contralateral to a moving limb.• In stroke, the LRP can lateralize contra-, or ipsilateral to the paretic limb depending on the stage of recovery.• Identification of hemisphere of recovery can guide further measures for enhancing brain plasticity. Background:Event related cortical potentials related
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Efficacy of mechanisms of neuroplasticity after a stroke Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2022-05-13 Danylo F. Cabral, Peter Fried, Sebastian Koch, Jordyn Rice, Tatjana Rundek, Alvaro Pascual-Leone, Ralph Sacco, Clinton B. Wright, Joyce Gomes-Osman
Background:The sequelae of stoke, including the loss and recovery of function, are strongly linked to the mechanisms of neuroplasticity. Rehabilitation and non-invasive brain stimulation (NIBS) paradigms have shown promise in modulating corticomotor neuroplasticity to promote functional recovery inindividuals post-stroke. However, an important limitation to these approaches is that while stroke recovery
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Combined effects of cerebellar tDCS and task-oriented circuit training in people with multiple sclerosis: A pilot randomized control trial Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2022-05-05 Andrea Baroni, Giacomo Magro, Carlotta Martinuzzi, Laura Brondi, Stefano Masiero, Giada Milani, Giulia Zani, Antonella Bergonzoni, Nino Basaglia, Sofia Straudi
Background:Balance and mobility impairments are frequent in people with multiple sclerosis, partly due to cerebellar dysfunctions. Task-oriented behavioural approaches were previously shown to promote physical function. The possibility exists that cerebellar transcranial direct current stimulation(ctDCS) applied during training, known to increase the excitability of the brain, can boost rehabilitation
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Scientific basis and active ingredients of current therapeutic interventions for stroke rehabilitation Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2022-05-04 Rajiv Ranganathan, Carson Doherty, Michael Gussert, Eva Kaplinski, Mary Koje, Chandramouli Krishnan
Background:Despite tremendous advances in the treatment and management of stroke, restoring motor and functional outcomes after stroke continues to be a major clinical challenge. Given the wide range of approaches used in motor rehabilitation, several commentaries have highlighted the lack of a clear scientific basis for different interventions as one critical factor that has led to suboptimal study
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Complex housing partially mitigates low dose radiation-induced changes in brain and behavior in rats Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2022-04-30 Anna. Kovalchuk, Richelle. Mychasiuk, Arif. Muhammad, Shakhawat. Hossain, Abhijit. Ghose, Charles. Kirkby, Esmaeel. Ghasroddashti, Olga. Kovalchuk, Bryan. Kolb
Purpose: In recent years, much effort has been focused on developing new strategies for the prevention and mitigation of adverse radiation effects on healthy tissues and organs, including the brain. The brain is very sensitive to radiation effects, albeit as it is highly plastic. Hence, deleterious radiation effects may be potentially reversible. Because radiation exposure affects dendritic space,
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Training with optic flow stimuli promotes recovery in cortical blindness Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2022-02-23 Asmara Awada, Shahab Bakhtiari, Catherine Legault, Celine Odier, Christopher C. Pack
Background:Cortical blindness is a form of severe vision loss that is caused by damage to the primary visual cortex (V1) or its afferents. This condition has devastating effects on quality of life and independence. While there are few treatments currently available, accumulating evidence shows thatcertain visual functions can be restored with appropriate perceptual training: Stimulus sensitivity can
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Activity dependent stimulation increases synaptic efficacy in spared pathways in an anesthetized rat model of spinal cord contusion injury Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2022-02-22 Jordan A. Borrell, Dora Krizsan-Agbas, Randolph J. Nudo, Shawn B. Frost
Abstract Background: Closed-loop neuromodulation systems have received increased attention in recent years as potential therapeutic approaches for treating neurological injury and disease. Objective: The purpose of this study was to assess the ability of intraspinal microstimulation (ISMS), triggered by action potentials (spikes) recorded in motor cortex, to alter synaptic efficacy in descending motor
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Retinal nerve fiber and ganglion cell complex layer thicknesses mirror brain atrophy in patients with relapsing-remitting multiple sclerosis Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2022-02-17 Paulina Glasner, Agnieszka Sabisz, Magdalena Chylińska, Jakub Komendziński, Adam Wyszomirski, Bartosz Karaszewski
Background:Multiple sclerosis (MS) is associated with progressive brain atrophy, which in turn correlates with disability, depression, and cognitive impairment. Relapsing-remitting multiple sclerosis (RRMS) is a type of MS in which relapses of the disease are followed by remission periods. This isthe most common type of the disease. There is a significant need for easy and low-cost methods to these
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Efficacy of fine motor and balance exercises on fine motor skills in children with sensorineural hearing loss Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2021-12-30 Elsayed S. Mehrem, Lamyaa A. Fergany, Said A. Mohamed, Hany M. Fares, Roshdy M. Kamel
Background: Childhood hearing impairment is a major disability associated with delayed motor development. The affected Fine motor performance in children with sensorineural hearing loss (SNHL) could be due to dynamic balance deficits and visual-motor incoordination. Objective: This study was designed to investigate the effects of fine motor exercises with or without balancing exercises on fine motor
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L-Carnitine prevents memory impairment induced by post-traumatic stress disorder Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2021-12-30 Karem H. Alzoubi, Arwa M. Al-Dekah, Saied Jaradat, Nasr Alrabadi
Background: Post-traumatic stress disorder (PTSD) is a genuine obstructing mental disorder. As indicated by the name, it is related to the patients’ stress augmented by life-threatening conditions or accidents. The PTSD has linked to oxidative stress that can result in neurodegeneration. L-carnitine (L-CAR) is known for its antioxidant properties, which can protect against neuronal damage. Objective:
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Combined transcranial Direct Current Stimulation and robot-assisted arm training in patients with stroke: a systematic review Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2021-12-28 Cristina Fonte, Valentina Varalta, Arianna Rocco, Daniele Munari, Mirko Filippetti, Elisa Evangelista, Angela Modenese, Nicola Smania, Alessandro Picelli
Background:Upper limb motor deficits in patients with severe stroke often remain unresolved over time. Combining transcranial Direct Current Stimulation with robotic therapy is an innovative neurorehabilitation approach that holds promise to improve upper limb impairment after stroke. Objective:Toinvestigate the effects of robotic training in combination with transcranial Direct Current Stimulation
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Non-invasive brain microcurrent stimulation therapy of long-COVID-19 reduces vascular dysregulation and improves visual and cognitive impairment Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2021-12-15 Bernhard A. Sabel, Wanshu Zhou, Frank Huber, Florentina Schmidt, Kornelia Sabel, Andreas Gonschorek, Mirela Bilc
Abstract Background: An effective treatment is needed for long-COVID patients which suffer from symptoms of vision and/or cognition impairment such as impaired attention, memory, language comprehension, or fatigue. Objective: Because COVID-19infection causes reduced blood flow which may cause neuronal inactivation, we explored if neuromodulation with non-invasive brain stimulation with microcurrent
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Combining inhibitory and facilitatory repetitive transcranial magnetic stimulation (rTMS) treatment improves motor function by modulating GABA in acute ischemic stroke patients Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2021-12-10 Qing-Mei Chen, Fei-Rong Yao, Hai-Wei Sun, Zhi-Guo Chen, Jun Ke, Juan Liao, Xiu-Ying Cai, Li-Qiang Yu, Zhen-Yan Wu, Zhi Wang, Xi Pan, Hao-Yu Liu, Li Li, Quan-Quan Zhang, Wei-Hua Ling, Qi Fang
Background:The combination of inhibitory and facilitatory repetitive transcranial magnetic stimulation (rTMS) can improve motor function of stroke patients with undefined mechanism. It has been demonstrated that rTMS exhibits a neuro-modulatory effect by regulating the major inhibitory neurotransmitter γ-aminobutyric acid (GABA) in other diseases. Objectives:To evaluate the effect of combined inhibitory
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Theta-burst transcranial magnetic stimulation for the treatment of unilateral neglect in stroke patients: A systematic review and best evidence synthesis Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2021-12-01 Milan Houben, Sabrina Chettouf, Ysbrand Van Der Werf, John Stins
Abstract Background: Unilateral neglect (UN) is a common and disabling disorder after stroke. UN is a strong and negative predictor of functional rehabilitative outcome. Non-invasive brain stimulation, such as theta-burst transcranial magnetic stimulation (TBS), is a promising rehabilitation technique for treating stroke-induced UN. Objective: To systematically review the available literature, researching
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Effect of conventional transcranial direct current stimulation devices and electrode sizes on motor cortical excitability of the quadriceps muscle Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2021-10-14 Adam Z. Gardi, Amanda K. Vogel, Aastha K. Dharia, Chandramouli Krishnan
Background:There is a growing concern among the scientific community that the effects of transcranial direct current stimulation (tDCS) are highly variable across studies. The use of different tDCS devices and electrode sizes may contribute to this variability; however, this issue has not been verified experimentally. Objective:To evaluate the effects of tDCS device and electrode size on quadriceps
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Effect of low-cost transcranial magnetic stimulation navigation on hotspot targeting and motor evoked potential variability in the biceps brachii Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2021-10-13 Thibault Roumengous, Alec B. Reutter, Carrie L. Peterson
Background:Transcranial magnetic stimulation (TMS) can monitor or modulate brain excitability. However, reliability of TMS outcomes depends on consistent coil placement during stimulation. Neuronavigated TMS systems can address this issue, but their cost limits their use outside of specialist research environments. Objective:The objective was to evaluate the performance of a low-cost navigated TMS
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The acute effects of aerobic exercise on sensorimotor adaptation in chronic stroke Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2021-09-18 Christopher P. Mackay, Sandra G. Brauer, Suzanne S. Kuys, Mia A. Schaumberg, Li-Ann Leow
Abstract Background: Sensorimotor adaptation, or the capacity to adapt movement to changes in the moving body or environment, is a form of motor learning that is important for functional independence (e.g., regaining stability after slips or trips). Aerobic exercise can acutely improve many forms of motor learning in healthy adults. It is not known, however, whether acute aerobic exercise has similar
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Effects of prolonged peri-neural bupivacaine infusion in rat sciatic nerves (axon and myelin) Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2021-09-15 John T. Butler, Tobias J. Robinson, Jared R. Edwards, Marjorie R. Grafe, Jeffrey R. Kirsch
Background/Objective:Peripheral-nerve blocks (PNBs) using continuous-infusion of local anesthetics are used to provide perioperative analgesia. Yet little research exists to characterize the histopathological effects of continuous long-duration PNBs. Herein we test the hypothesis that continuous peri-neural bupivacaine infusion (3-day vs. 7-day infusion) contributes to histologic injury in a duration-dependent
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Tele-rehabilitation of upper-extremity hemiparesis after stroke: Proof-of-concept randomized controlled trial of in-home constraint-induced movement therapy Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2021-08-21 Gitendra Uswatte, Edward Taub, Peter Lum, David Brennan, Joydip Barman, Mary H. Bowman, Andrea Taylor, Staci Mckay, Samantha B. Sloman, David M. Morris, Victor W. Mark
Background:Although Constraint-Induced Movement therapy (CIMT) has been deemed efficacious for adults with persistent, mild-to-moderate, post-stroke upper-extremity hemiparesis, CIMT is not available on a widespread clinical basis. Impediments include its cost and travel to multiple therapy appointments. To overcome these barriers, we developed an automated, tele-health form of CIMT. Objective:Determine
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Simultaneously stimulating both brain hemispheres by rTMS in patients with unilateral brain lesions decreases interhemispheric asymmetry Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2021-07-30 Yuhua Zhong, Jianzhong Fan, Huijuan Wang, Renhong He
Background:Interhemispheric asymmetry caused by brain lesions is an adverse factor in the recovery of patients with neurological deficits. Repetitive transcranial magnetic stimulation (rTMS) has been shown to modulate cortical oscillation and proposed as an approach to rebalance the symmetry, whichhas not been documented well. Objective:In this study, we investigated the influence of repetitive transcranial
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Repetitive transcranial magnetic stimulation on the modulation of cortical and spinal cord excitability in individuals with spinal cord injury Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2021-07-29 Thyciane Mendonça, Rodrigo Brito, Plínio Luna, Mayara Campêlo, Lívia Shirahige, Luís Fontes, Rebeca Dias, Daniele Piscitelli, Kátia Monte-Silva
Background:Repetitive transcranial magnetic stimulation (rTMS) has been applied for modulating cortical excitability and treating spasticity in neurological lesions. However, it is unclear which rTMS frequency is most effective in modulating cortical and spinal excitability in incomplete spinal cord injury (SCI). Objective:To evaluate electrophysiological and clinical repercussions of rTMS compared
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Immuno-histological detection of resistant columnar units and vulnerable networks in the rat retina after asphyxia-induced transient cardiac arrest Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2021-07-28 Gerburg Keilhoff, Maximilian Titze, Uwe Ebmeyer
Background:Stroke-related loss of vision is one of the residual impairments, restricting the quality of life. However, studies of the ocular manifestations of asphyxia cardiac arrest/resuscitation (ACA/R) have reported very heterogeneous results. Objective:We aimed to evaluate the ACA/R-induced degeneration pattern of the different retinal cell populations in rats using different immuno-histological
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Structural connectivity changes in the motor execution network after stroke rehabilitation Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2021-07-11 Pradeepa Ruwan Wanni Arachchige, Sadhani Karunarathna, Abdul Chalik Meidian, Ryo Ueda, Wataru Uchida, Atsushi Senoo
Background:Although quite a very few studies have tested structural connectivity changes following an intervention, it reflects only selected key brain regions in the motor network. Thus, the understanding of structural connectivity changes related to the motor recovery process remains unclear. Objective:This study investigated structural connectivity changes of the motor execution network following
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Transcriptome analysis of human dorsal striatum implicates attenuated canonical WNT signaling in neuroinflammation and in age-related impairment of striatal neurogenesis and synaptic plasticity Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2021-07-11 Chun Wu, Raphael M. Bendriem, William J. Freed, Chun-Ting Lee
Background:Motor and cognitive decline as part of the normal aging process is linked to alterations in synaptic plasticity and reduction of adult neurogenesis in the dorsal striatum. Neuroinflammation, particularly in the form of microglial activation, is suggested to contribute to these age-associated changes. Objective and Methods:To explore the molecular basis of alterations in striatal function
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Non-invasive electrical brain stimulation for vision restoration after stroke: An exploratory randomized trial (REVIS) Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2021-06-28 Silja Räty, Carolin Borrmann, Giuseppe Granata, Lizbeth Cárdenas-Morales, Ariel Schoenfeld, Michael Sailer, Katri Silvennoinen, Juha Holopainen, Francesca De Rossi, Andrea Antal, Paolo M. Rossini, Turgut Tatlisumak, Bernhard A. SABEL
Background:Occipital strokes often cause permanent homonymous hemianopia leading to significant disability. In previous studies, non-invasive electrical brain stimulation (NIBS) has improved vision after optic nerve damage and in combination with training after stroke. Objective:We explored different NIBS modalities for rehabilitation of hemianopia after chronic stroke. Methods:In a randomized, double-blinded
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Cryptotanshinone reduces neurotoxicity induced by cerebral ischemia-reperfusion injury involving modulation of microglial polarization Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2021-06-27 Yanfang Mao, Yang Qu, Qingdong Wang
Background:The diterpenoid cryptotanshinone (CTS) has wide biological functions, including inhibition of tumor growth, inflammation and apoptosis. The present study aimed to explore the possible effect of CTS on cerebral ischemia/reperfusion (I/R) injury and the underlying mechanisms. Methods:MaleC57BL/6J mice underwent transient middle cerebral artery occlusion (tMCAO) and murine microglia BV2 cells
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Navigated perilesional transcranial magnetic stimulation can improve post-stroke visual field defect: A double-blind sham-controlled study Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2021-05-18 Nevine El Nahas, Ahmed M. Elbokl, Eman Hamid Abd Eldayem, Tamer M. Roushdy, Randa M. Amin, Shahinaz M. Helmy, Ahmed Zaki Akl, Aya Ahmed Ashour, Shady Samy, Alaa Amgad, Tamer H. Emara, Mohamed Nowara, Fatma Fathalla Kenawy
Background:Visual field defects (VFD) usually do not show improvement beyond 12 weeks from their onset. It has been shown that repetitive presentation of a stimulus to areas of residual vision in cases of visual field defect can improve vision. The counterpart of these areas in the brain are the partially damaged brain regions at the perilesional areas where plasticity can be enhanced. Objective:We
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Protective effect of caffeine and/or taurine on the 6-hydroxydopamine-induced rat model of Parkinson’s disease: Behavioral and neurochemical evidence Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2021-05-10 Amjad N. Abuirmeileh, Sawsan M. Abuhamdah, Asser Ashraf, Karem H. Alzoubi
Background:Caffeine and taurine, which possess neuro-modulatory activity happen to be consumed together as part of the constituents of energy drinks, could have beneficial effects and prevent neuronal deterioration in Parkinson’s disease (PD). Objective:This study aimed to investigate behavioral and neurochemical effects of these two agents in an animal model of PD at two time points to evaluate possible
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An action-observation/motor-imagery based approach to differentiate disorders of consciousness: what is beneath the tip of the iceberg? Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2021-05-10 Antonino Naro, Loris Pignolo, Lucia Francesca Lucca, Rocco Salvatore Calabrò
Background:The evaluation of motor imagery in persons with prolonged Disorders of Consciousness (pDOC) is a practical approach to differentiate between patients with Minimally Conscious State (MCS) and Unresponsive Wakefulness Syndrome (UWS) and to identify residual awareness even in individuals with UWS. Investigating the influence of motor observation on motor imagery could be helpful in this regard
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Physical exercise increases peripheral brain-derived neurotrophic factors in patients with cognitive impairment: A meta-analysis Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2021-05-10 Hong Huang, Wenyang Li, Zheng Qin, Hui Shen, Xiaomeng Li, Wei Wang
Background:Physical exercise can improve cognitive dysfunction. Its specific mechanism remains unknown. Recent studies have indicated that elevating or peripherally overexpressing brain-derived neurotrophic factors (BDNF) improve cognitive impairment. Objective:This meta-analysis aimed to investigate whether physical exercise improves cognitive performance in patients with cognitive dysfunction, such
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Effect of home-based rehabilitation of purposeful activity-based electrical stimulation therapy for chronic stroke survivors: a crossover randomized controlled trial Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2021-05-10 Seigo Minami, Yoshihiro Fykumoto, Ryuji Kobayashi, Hideaki Aoki, Tomoki Aoyama
Abstract Background: In this trial we combined the effect of purposeful activity and electrical stimulation therapy (PA-EST) to promote transition of severely hemiparetic upper limb to auxiliary upper limb in chronic stroke survivors in a single-case study. Objective: The purpose of this study was to examine the effect of PA-EST on the upper limb motor function in a crossover randomized controlled
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Functional recoveries of patients with branch atheromatous disease after rehabilitation: Comparison with other types of cerebral infarction and importance of stratification by clinical categories Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2021-04-30 Yoshinobu Okuda, Futoshi Aoike, Jo Matsuzaki, Shoichi Shiraishi, Shintaro Sugiyama, Tomoko Yoshida, Emi Kitamura, Fukuko Nishida, Natsuki Tanaka, Yasuko Sugiyama, Tomomi Enami, Takehiko Yanagihara
Background:Functional recoveries after rehabilitation of patients with branch atheromatous disease (BAD) have not been well investigated, however, clinical category of cerebral infarction including BAD itself could be a potential predictive factor for functional outcome. Objective:To describe characteristics of functional recoveries of patients with BAD through comparison with other types of cerebral
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Effects of an evidence-based nursing intervention on neurological function and serum inflammatory cytokines in patients with acute cerebral infarction: A randomized controlled trial Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2021-04-28 Yaping Liu, Mingwei Qu, Nan Wang, Limin Wang
Background:Acute cerebral infarction is a clinically common and critical disease which seriously endangers the life and safety of elderly patients. Evidence-based nursing is an effective way of nursing and has great significance in improving the neurological function and quality of life of patients. In China, evidence-based nursing has been highlighted and highly developed in recent decades. Objectives:This
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Removal of a compressive mass causes a transient disruption of blood-brain barrier but a long-term recovery of spiny stellate neurons in the rat somatosensory cortex Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2021-04-02 Tzu-Yin Yeh, Pei-Hsin Liu
Background:In the cranial cavity, a space-occupying mass such as epidural hematoma usually leads to compression of brain. Removal of a large compressive mass under the cranial vault is critical to the patients. Objective:The purpose of this study was to examine whether and to what extent epidural decompression of the rat primary somatosensory cortex affects the underlying microvessels, spiny stellate
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Electrical stimulation of referred sensation area alleviates phantom limb pain Restor. Neurol. Neurosci. (IF 2.8) Pub Date : 2021-03-05 Michihiro Osumi, Daisuke Shimizu, Yuki Nishi, Shu Morioka
Background:Patients with brachial plexus avulsion (BPA) usually experience phantom sensations and phantom limb pain (PLP) in the deafferented limb. It has been suggested that evoking the sensation of touch in the deafferented limb by stimulating referred sensation areas (RSAs) on the cheek or shoulder might alleviate PLP. However, feasible rehabilitation techniques using this approach have not been