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Extrasynaptic distribution of NMDA receptors in cochlear inner hair cell afferent signaling complex J. Chem. Neuroanat. (IF 2.8) Pub Date : 2024-04-01 Juan Hong, Peidong Dai, Huazheng Liang, Guangbin Sun, Weidong Qi, Yong Bi
The distribution and role of NMDA receptors is unclear in the afferent signaling complex of the cochlea. The present study aimed to examine the distribution of NMDA receptors in cochlear afferent signaling complex of the adult mouse, and their relationship with ribbon synapses of inner hair cells (IHCs) and GABAergic efferent terminals of the lateral olivocochlear (LOC). Immunofluorescence staining
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The neurobiological effects of senescence on dopaminergic system: A comprehensive review J. Chem. Neuroanat. (IF 2.8) Pub Date : 2024-03-21 Gabriel S. Rocha, Marco Aurelio M. Freire, Karina M. Paiva, Rodrigo F. Oliveira, Paulo Leonardo A.G. Morais, José Ronaldo Santos, José Rodolfo L.P. Cavalcanti
Over time, the body undergoes a natural, multifactorial, and ongoing process named senescence, which induces changes at the molecular, cellular, and micro-anatomical levels in many body systems. The brain, being a highly complex organ, is particularly affected by this process, potentially impairing its numerous functions. The brain relies on chemical messengers known as neurotransmitters to function
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Olfactory ensheathing cells as candidate cells for chronic pain treatment J. Chem. Neuroanat. (IF 2.8) Pub Date : 2024-03-14 Mei-chen Liu, Qing-fa Guo, Wei-wei Zhang, Hong-liang Luo, Wen-jun Zhang, Hai-jun Hu
Chronic pain is often accompanied by tissue damage and pain hypersensitivity. It easily relapses and is challenging to cure, which seriously affects the patients’ quality of life and is an urgent problem to be solved. Current treatment methods primarily rely on morphine drugs, which do not address the underlying nerve injury and may cause adverse reactions. Therefore, in recent years, scientists have
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DNA methylation-altered genes in the rat hippocampal neurogenic niche after continuous exposure to amorphous curcumin J. Chem. Neuroanat. (IF 2.8) Pub Date : 2024-03-13 Qian Tang, Ryota Ojiro, Shunsuke Ozawa, Xinyu Zou, Junta Nakahara, Tomohiro Nakao, Mihoko Koyanagi, Meilan Jin, Toshinori Yoshida, Makoto Shibutani
Rat offspring who are exposed to an amorphous formula of curcumin (CUR) from the embryonic stage have anti-anxiety-like behaviors, enhanced fear extinction learning, and increased synaptic plasticity in the hippocampal dentate gyrus (DG). In the present study, we investigated the links between genes with altered methylation status in the neurogenic niche and enhanced neural functions after CUR exposure
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The possible protective effect of l-cysteine in a rat model of sciatic nerve ischemia-reperfusion: A possible role for NRF1 and Caspase 3; Biochemical, Histological, and Immunohistochemical study J. Chem. Neuroanat. (IF 2.8) Pub Date : 2024-03-07 Sara Mohamed Naguib Abdel Hafez, El-Shimaa M.N. abdelhafez
Organ damage brought on by ischemia is exacerbated by the reperfusion process. L-cysteine is a semi-essential amino acid that acts as a substrate for cystathionine-β-synthase in the central nervous system. The aim of this study was to investigate the possible protective effects of L- cysteine against the structural and biochemical changes that occur in the rat sciatic nerve after ischemia reperfusion
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Oxytocin-receptor-expressing neurons in the lateral parabrachial nucleus activate widespread brain regions predominantly involved in fluid satiation J. Chem. Neuroanat. (IF 2.8) Pub Date : 2024-03-06 Janine C.M. Jaramillo, Connor M. Aitken, Andrew J. Lawrence, Philip J. Ryan
Fluid satiation is an important signal and aspect of body fluid homeostasis. Oxytocin-receptor-expressing neurons (Oxtr) in the dorsolateral subdivision of the lateral parabrachial nucleus (dl LPBN) are key neurons which regulate fluid satiation. In the present study, we investigated brain regions activated by stimulation of Oxtr neurons in order to better characterise the fluid satiation neurocircuitry
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The neuroprotective effects of baobab and black seed on the rat hippocampus exposed to a 900-MHz electromagnetic field J. Chem. Neuroanat. (IF 2.8) Pub Date : 2024-03-04 Hamza Mohamed, Omur Gulsum Deniz, Suleyman Kaplan
This study investigated the potential effects on the hippocampus of electromagnetic fields (EMFs) disseminated by mobile phones and the roles of baobab () (AD) and black seed () (BS) in mitigating these. Fifty-six male, 12-week-old rats were divided into eight groups of seven animals each. No EMF exposure was applied to the control, AD or BS groups, while the rats in the Sham group were placed in an
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Curcumin abrogates cobalt-induced neuroinflammation by suppressing proinflammatory cytokines release, inhibiting microgliosis and modulation of ERK/MAPK signaling pathway J. Chem. Neuroanat. (IF 2.8) Pub Date : 2024-02-28 Rademene S. Oria, Godson E. Anyanwu, Johnson N. Nto, James O. Ikpa
Curcumin, a bioactive polyphenol derived from turmeric, has been reported to have anti-inflammatory properties. The current study investigated the anti-inflammatory effect of curcumin in the hippocampal subfields (CA1 and CA3) after exposure to cobalt (Co) and the impact of ERK protein. Twenty-eight albino Wistar rats were divided into four groups, each with seven randomly selected rats as follows:
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Protective effects of myricetin and morin on neurological damage in Aβ1–42/Al3+ -induced Alzheimer’s disease model of rats J. Chem. Neuroanat. (IF 2.8) Pub Date : 2024-02-27 Linli Guo, Yanan Zhao, Zhengqiao Kong, Ruihua Liu, Ping Liu
Alzheimer's disease (AD) is a degenerative neurological disorder with unclear pathogenesis. Single-target drugs have very limited efficacy in treating AD, but synthetic multi-target drugs have poor efficacy and safety. Therefore, finding suitable natural multi-target drugs against AD is of great interest for research studies. We chose two flavonols, myricetin and morin, for the relevant study. In this
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Elderberry diet enhances motor performance and reduces neuroinflammation-induced cell death in cerebellar ataxia rat models. J. Chem. Neuroanat. (IF 2.8) Pub Date : 2024-02-23 Maryam Raoofi nejad, Elham Siasi., Mohammad Amin Abdollahifar, Abbas Aliaghaei, Elham Siasi
Cerebellar ataxia (CA) is a condition in which cerebellar dysfunction results in movement disorders such as dysmetria, synergy and dysdiadochokinesia. This study investigates the therapeutic effects of elderberry (EB) diet on the 3-acetylpyridine-induced (3-AP) CA rat model. First, CA rat models were generated by 3-AP administration followed by elderberry diet treatment containing 2% EB for 8 consecutive
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Investigating the Impact of Nutritional Insufficiency on Parahippocampal Neurons in Domestic Chickens, Gallus gallus domesticus J. Chem. Neuroanat. (IF 2.8) Pub Date : 2024-02-20 Adarsh Kumar, Kavita Tamta, Hemlata Arya, Shweta Arya, Ram Chandra Maurya
Over time, scientists have been fascinated by the complex connections among nutrition, brain development, and behavior. It's been well understood that the brain's peak performance relies on having the right nutrients available. Thus, nutritional insufficiency, where an organism lacks vital nutrients crucial for optimal growth and function, can upset the body's balance, potentially triggering stress
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Spexin and nesfatin-1-expressing neurons in the male human claustrum J. Chem. Neuroanat. (IF 2.8) Pub Date : 2024-02-09 Artur Pałasz, Anna Lipiec-Borowicz, Aleksandra Suszka-Świtek, Julia Kistowska, Petra Horká, Andrzej Kaśkosz, Aneta Piwowarczyk-Nowak, John J. Worthington, Kinga Mordecka-Chamera
Neuropeptides are involved in numerous brain activities being responsible for a wide spectrum of higher mental functions. The purpose of this concise, structural and qualitative investigation was to map the possible immunoreactivity of the novel regulatory peptides: spexin (SPX) and nesfatin-1 within the human claustrum. SPX is a newly identified peptide, a natural ligand for the galanin receptors
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The protective effect of methanolic extract of Verbascum cheiranthifolium and Biebersteinia multifida DC on hippocampus damage induced by diazinon in male Wistar rats: An experimental study J. Chem. Neuroanat. (IF 2.8) Pub Date : 2024-02-09 Amir Delavar, Fatemeh Rahimi Anbarkeh, Raheleh Baradaran, Zohreh Arab, Seyed Hamidreza Rastegar Moghaddam, Mahmoud Hosseini, Mohammad Reza Nikravesh, Shahin Saeidi Nejat, Mehdi Jalali
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Tetrahydropiperine, a natural alkaloid with neuroprotective effects in ischemic stroke J. Chem. Neuroanat. (IF 2.8) Pub Date : 2024-02-07 Hongyan Ren, Qianqian Yuan, Jiayuan Lu, Siyu Xi, Yanbo Liu, Guangyu Yang, Zhixi Xie, Bo Wang, Li Ma, Xueyan Fu, Juan Liu, Yiwei Zhang
Ischemic stroke (IS) is a life-threatening neurological disease with various pathological mechanisms. Tetrahydropiperine (THP) is a natural alkaloid with protective effects against multiple diseases, such as seizure, and pain. This study was to examine the impact of THP on IS and investigate its potential mechanism. We employed network pharmacology and molecular docking techniques to identify the target
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The assessment of neuronal plasticity following sciatic nerve injuries in rats using electron microscopy and stereological methods J. Chem. Neuroanat. (IF 2.8) Pub Date : 2024-02-06 Burcu Delibaş, John-Mary Vianney, Süleyman Kaplan
The transmission of signals to the cell body from injured axons induces significant alterations in primary sensory neurons located in the ganglion tissue, the site of the perikaryon of the affected nerve fibers. Disruption of the continuity between the proximal and distal ends leads to substantial adaptability in ganglion cells and induces macrophage-like activity in the satellite cells. Research findings
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The effects of Garcinia kola and curcumin on the dorsal root ganglion of the diabetic rat after peripheral nerve transection injury J. Chem. Neuroanat. (IF 2.8) Pub Date : 2024-02-05 Abit Aktaş, Funda Yiğit, Burcu Delibaş, Arife Ahsen Kaplan, Hala Mahgoub Hamour, Abdullah Hilmi Marangoz, Ayşenur Kaya, Gamze Altun, Süleyman Kaplan
To test the protective effects of and curcumin on the ganglion tissues of diabetic rats following the use of autologous vein graft in peripheral nerve transection injury. The sciatic nerve on the right side was transected, and anastomosis was performed between the proximal and distal ends using an autologous vein graft. Curcumin and seed extract were administered daily by oral gavage. The ganglion
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Celebrating 37 years of dedication: Reflections on the past and looking toward the future J. Chem. Neuroanat. (IF 2.8) Pub Date : 2024-01-22 Goran Šimić, Gail M. Rodney
Abstract not available
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Oxyberberine protects middle cerebral artery occlusion triggered cerebral injury through TLR4/NLRP3 pathway in rats J. Chem. Neuroanat. (IF 2.8) Pub Date : 2024-01-19 Ziaur Rahman, Arbaz Sujat Shaikh, K. Venkata Rao, Manoj P. Dandekar
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The habenula in Parkinson's disease: Anatomy, function, and implications for mood disorders − A narrative review J. Chem. Neuroanat. (IF 2.8) Pub Date : 2024-01-17 Bedia Samanci, Sonny Tan, Stijn Michielse, Mark L. Kuijf, Yasin Temel
Parkinson's disease (PD), a widespread neurodegenerative disorder, often coexists with mood disorders. Degeneration of serotonergic neurons in brainstem raphe nuclei have been linked to depression and anxiety. Additionally, the locus coeruleus and its noradrenergic neurons are among the first areas to degenerate in PD and contribute to stress, emotional memory, motor, sensory, and autonomic symptoms
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The effects of induced type I diabetes on developmental regulation of GDNF, NRTN, and NCAM proteins in the dentate gyrus of male rat offspring J. Chem. Neuroanat. (IF 2.8) Pub Date : 2024-01-14 Hamideh Mostafaee, Faezeh Idoon, Mina Mohasel-Roodi, Fatemeh Alipour, Nasim Lotfi, Akram Sadeghi
Maternal diabetes during pregnancy can affect the neurological development of offspring. Glial cell-derived neurotrophic factor (GDNF), neurturin (NRTN), and neural cell adhesion molecules (NCAM) are three important proteins for brain development. Therefore, this study aimed to investigate the impacts of the mentioned neurotrophic factors in the hippocampal dentate gyrus (DG) of rat offspring born
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Chemical components and against alzheimer's disease effects of the calyxes of Physalis alkekengi L. var. franchetii (Mast.) Makino J. Chem. Neuroanat. (IF 2.8) Pub Date : 2024-01-14 Yang Teng, Jia Gao, Tian Tan, Xiangrong Zhang, Yuliang Wang, Jiaguang Zhang, Lei Ni
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Astrocyte response to melatonin treatment in rats under high-carbohydrate high-fat diet J. Chem. Neuroanat. (IF 2.8) Pub Date : 2024-01-10 Davood Dorranipour, Fahimeh Pourjafari, Reza Malekpour-Afshar, Mohsen Basiri, Mehran Hosseini
The involvement of consumption of high-carbohydrate high-fat (HCHF) diet in cognitive impairment is attributed, at least in part, to the activation of astrocytes, which contributes to the development of neuroinflammation, oxidative stress, and subsequent cognitive deficits. This study aimed to assess the influence of melatonin on cognitive impairment and astrogliosis induced by the HCHF diet in rats
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Chronic sub lethal nerve agent (Soman) exposure induced long-term neurobehavioral, histological, and biochemical alterations in rats J. Chem. Neuroanat. (IF 2.8) Pub Date : 2024-01-04 RamaRao Golime, Naveen Singh, Ankush Rajput, Nagar DP, Vinod K. Lodhi
Organophosphorus (OP) pesticides and insecticides are used in agriculture and other industries can also cause adverse effects through environmental exposures in the people working in agricultural and pesticide industries. OP nerve agent exposures have been associated with delayed neurotoxic effects including sleep disorders, cognitive malfunctions, and brain damage in Gulf War victims, and Japanese
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Network pharmacology analysis and experimental validation to explore the effect and mechanism of tetramethylpyrazine for spinal cord injury J. Chem. Neuroanat. (IF 2.8) Pub Date : 2024-01-03 Guodong Qi, Shujun Li, Qiong Jiang, Zhijuan Yu, Zhenggang Peng, Qiurui Li, Wei Qi, Mingjun Guo
To investigate the effect and mechanism of Tetramethylpyrazine (TMP) in treating Spinal Cord Injury (SCI) using network pharmacology analysis and animal experiments. This study was based on public databases, including PharmMapper, BATMAN-TCM, and STRING, as well as KEGG pathway analysis and other methods of network pharmacology were used to preliminarily explore the molecular mechanism of TMP in the
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Ozone-mediated cerebral protection: Unraveling the mechanism through ferroptosis and the NRF2/SLC7A11/GPX4 signaling pathway J. Chem. Neuroanat. (IF 2.8) Pub Date : 2024-01-03 Farong Zhu, Shengyang Ding, Yu Liu, Xinlei Wang, Zhouquan Wu
The pathogenesis of brain ischemic/reperfusion (I/R) insult is characterized by neuronal loss due to excessive oxidative stress responses. Ferroptosis, a form of oxidative cell death, can be triggered when the balance between antioxidants and pro-oxidants in cells is disrupted. Ozone, a natural bioactive molecule with antioxidant/anti-apoptotic and pro-autophagic properties, has been shown to enhance
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Neurobehavioral deficits, histoarchitectural alterations, parvalbumin neuronal damage and glial activation in the brain of male Wistar rat exposed to Landfill leachate J. Chem. Neuroanat. (IF 2.8) Pub Date : 2024-01-02 Usende Ifukibot Levi, Mofio M. Bintu, Osinachi Chinonyerem Daniella, Oyelowo-Abdulraheem Fatima Oyenike, Adikpe Oluwa Agbonu, Azeez Mariam Adedamola, Enefe Ndidi, Sanni Fatimah Saka, Beselia V. Gela, Smart I. Mbagwu, Edem Ekpenyong Edem, Olopade James Olukayode, Connor James
Concerns about inappropriate disposal of waste into unsanitary municipal solid waste landfills around the world have been on the increase, and this poses a public health challenge due to leachate production. The neurotoxic effect of Gwagwalada landfill leachate (GLL) was investigated in male adult Wistar rats. Rats were exposed to a 10% concentration of GLL for 21 days. The control group received tap
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Icariin attenuates dopaminergic neural loss in haloperidol-induced Parkinsonism in rats via GSK-3β and tyrosine hydroxylase regulation mechanism J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-12-30 Hend A. Sabry, Mai M. Zahra
Parkinson’s Disease (PD) is an age-dependent, incessant, dynamic neurodegenerative illness. In animal models, the administration of the dopaminergic D2 antagonist Haloperidol (HP) affects the nigrostriatal pathway, inducing catalepsy, a state of immobility like PD, bradykinesia, and akinesia. The present study investigated the neural effects of Icariin (ICA), a flavonoid derived from , against HP-induced
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Rehabilitation training enhanced the therapeutic effect of calycosin on neurological function recovery of rats following spinal cord injury J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-12-26 Mingdong Li, Yanqiang Huan, Tianqi Jiang, Yongxiong He, Zengxin Gao
Calycosin (CA), a flavonoids component, has demonstrated potential neuroprotection effects by inhibiting oxidative stress in spinal cord injury (SCI) models. This study aims to investigate the impact of combined rehabilitation training (RT) and calycosin therapy on neurological function following SCI, primarily by assessing changes in motor function recovery, neuronal survival, neuronal oxidative stress
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Electroacupuncture protects against the striatum of ischemia stroke by inhibiting the HMGB1/RAGE/p-JNK signaling pathways J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-12-19 Zeyin Nie, Chenying Hu, Huachun Miao, Feng Wu
The striatum (Str) is injured 20 min after permanent ischemic stroke, leading to neurological deficits. Here, we aimed to explore the effect of electroacupuncture (EA) on ischemic stroke and elucidate the possible underlying mechanism. Rat permanent middle cerebral artery occlusion (pMCAO) model, EA treatment, sham-EA (SEA) treatment, beam-balance test, hematoxylin and eosin (HE) staining, Nissl staining
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Solifenacin promotes remyelination in cuprizone mouse model by inhibiting the Wnt/β-catenin signaling pathway J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-12-18 Xinqi Xu, Xueli Song, Fei Chen, Weixing Yan, Qiqi Meng, Jinfeng Liu, Ruiqin Yao, Yaping Liu, Fuxing Dong
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Coenzyme Q10 attenuates neurodegeneration in the cerebellum induced by chronic exposure to tramadol J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-12-01 Majid Keyhanifard, Roghayeh Javan, Reza Ataee Disfani, Maryam Bahrami, Mohamad Sedigh Mirzaie, Saeid Taghiloo, Hossein Mokhtari, Davood Nasiry, Zahra Sadrzadeh Aghajani, Mahdi Shooraj
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Supplementation with Vitamins D3 and A Mitigates Parkinsonism in a Haloperidol Mice Model J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-11-29 Badamasi M. Ibrahim, John C. Oyem, Sirajo M. Umar
Background Earlier reports suggest that vitamin D3 (Vit D3) supplementation attenuates Parkinsonism in drug-induced motor deficits. Moreover, the function of Vit D3 may be optimized by co-administration with vitamin A (Vit A). In line with the synergistic interplay between vitamins, we hypothesized that the efficacy of Vit D3 to attenuate Parkinsonism in a haloperidol-induced mouse model of motor deficits
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Aqueous leaf extract of Phyllanthus amarus protects against oxidative stress and misfiring of dopaminergic neurons in Paraquat-induced Parkinson’s disease-like model of adult Wistar rats J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-11-27 Felix U. Enemali, Kingsley Afoke Iteire, Raphael E. Uweigho, Ogunberi Blessing, Gbayisomore Tolulope Judah
Background of the study Phyllanthus amarus has high nutritional value and is beneficial in managing and treating diverse ailments. This study assessed the role of aqueous leaf extract of Phyllanthus amarus on Paraquat (PQ) induced neurotoxicity in the substantia nigra of Wistar rats. Materials and methods The role of aqueous leaves extract of Phyllanthus amarus was assessed using an open field test
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Gallic acid ameliorates behavioral dysfunction, oxidative damage, and neuronal loss in the prefrontal cortex and hippocampus in stressed rats J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-11-26 Gholam Hossein Meftahi, Nahid Aboutaleb
Gallic acid (GA) is known to be a natural phenolic compound with antioxidant and neuroprotective effects. This study aims to investigate the impact of GA against restraint stress-induced oxidative damage, anxiety-like behavior, neuronal loss, and spatial learning and memory impairment in male Wistar rats. The animals were divided into four groups (n = 8) and subjected to restraint stress for 4 h per
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Curcumin alleviates Alzheimer’s disease by inhibiting inflammatory response, oxidative stress and activating the AMPK pathway J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-11-19 Sen Shao, Xiaojun Ye, Wenwen Su, Yanbo Wang
Background Alzheimer’s disease (AD) is a common degenerative brain disorder with limited therapeutic options. Curcumin (Cur) exhibits neuroprotective function in many diseases. We aimed to explore the role and mechanism of Cur in AD. Materials and Methods Firstly, we established AD mice by injecting amyloid-β1–42 (Aβ1–42) solution into the hippocampus. Then, the AD mice received 150 mg/kg/d Cur for
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Spatiotemporal expression patterns of ZBP1 in the brain of mouse experimental stroke model J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-11-10 Tohru Mutoh, Hiroshi Kikuchi, Tatsuya Jitsuishi, Keiko Kitajo, Atsushi Yamaguchi
Z-DNA binding protein 1 (ZBP1) is a cytosolic nucleic acid sensor, functioning as a critical mediator of inflammation and cell death pathways. Since neuroinflammation could occur in response to damage-associated molecular patterns (DAMPs), ZBP1 might be involved in neuroinflammation after stroke. However, the spatiotemporal expression profile of ZBP1 in the post-stroke brain remains to be elucidated
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Effect of royal jelly on acrylamide-induced neurotoxicity in rats J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-11-02 Doaa S. Ibrahim, Eman M.S. Shahen
Royal Jelly (RJ) is a natural product made by nurse bees known for its multiple therapeutic properties. The research aims to discover the ability of RJ to improve the hematological alterations and neurotoxicity caused by acrylamide (AA). The study rats were separated equally into four groups (6 in each group), the control group, the AA (38.27 mg/kg bw) group, the RJ (150 mg/kg bw) + AA group, and the
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Synaptamide modulates glial and neurotransmitter activity in the spinal cord during neuropathic pain J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-11-05 Anna Starinets, Arina Ponomarenko, Anna Tyrtyshnaia, Igor Manzhulo
N-docosahexaenoylethanolamine, or synaptamide, is an endogenous metabolite of docosahexaenoic acid that is known for synaptogenic and neurogenic effects. In our previous studies we have shown that synaptamide attenuates neuropathic pain, facilitates remyelination, and reduces neuroinflammation after the chronic constriction injury (CCI) of the sciatic nerve in rats. In the current study, we show that
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Lymphatic vessels accompanying dorsal and basal dural sinuses in the human brain J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-10-28 Safiye Çavdar, Büşra Köse, Damlasu Altınöz, Gizem Söyler, Ahmet Cingöz, İlke Ali Gürses, Mazhar Özkan, Hızır Aslıyüksek, Halit Çakır
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Suanzaoren decoction improves depressive-like behaviors by regulating the microbiota-gut-brain axis via inhibiting TLR4/NFκB/NLRP3 inflammation signal pathway J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-10-23 Yiyang Du, Bosai He, Bo Wu, Tingxu Yan, Ying Jia
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An investigation of the endoplasmic reticulum stress in obesity exposure in the prenatal period J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-10-17 Kıymet Kübra Tüfekci̇, Musa Tatar, Funda Terzi̇, Elfide Gizem Bakirhan
Objectives Exposure to maternal obesity has been shown to make offspring more prone to cognitive and metabolic disorders later in life. Although the underlying mechanisms are unclear, the role of endoplasmic reticulum (ER) stress in the fetal programming process is remarkable. ER stress can be activated by many chronic diseases, including obesity and diabetes. Therefore, our study aimed to investigate
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Immunoreactivity of glutamine synthetase in satellite glia around various subpopulations of lumbar dorsal root ganglia neurons in adult rats treated with monosodium glutamate J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-10-13 Aleksandra Krawczyk, Sylwia Mozel, Karol Rycerz, Jadwiga Jaworska-Adamu, Marcin Bartłomiej Arciszewski
Satellite glial cells (SGCs), involved inter alia in glutamate (Glu) metabolism, form a glial sheath around sensory neurons of dorsal root ganglia (DRGs). SGCs show a presence of glutamine synthetase (GS) which transform uptaken Glu into glutamine (Gln). In DRGs, this aminoacid is used mainly by small neurons which are able to synthetize substance P (SP) that play a crucial role in nociception. The
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Ginsenoside Rg2 alleviates neurovascular damage in 3xTg-AD mice with Alzheimer's disease through the MAPK-ERK pathway J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-10-05 Xiaojun Ye, Sen Shao, Yanbo Wang, Wenwen Su
Alzheimer's disease (AD) is the most common form of dementia, and ginsenoside Rg2 (Rg2) is proven to inhibit AD’s progression. This study investigates the potential benefits of Rg2 treatment on 3xTg-AD mice. Following 6 weeks of gavage treatment, Rg2-treated 3xTg-AD mice exhibited improved spatial recognition memory behaviors, regional cerebral blood flow, and histopathological injury of the hippocampus
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Thimet oligopeptidase (THOP 1) distribution in cane toad (Bufo Marinus, Linnaeus, 1758) brain J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-09-30 Diogo M.L.P. Cavalcanti, Tiago S. Teófilo, Tayline D. Rodrigues, Tayssa N.S. Barbosa, José D. Fontenele-Neto
Thimet oligopeptides (THOP 1) is a metal-dependent peptidase involved in the metabolism of neuropeptides and the presentation of peptides via MHC-1. It has been shown to play a role in the regulation of protein-protein interactions and the metabolism of intracellular peptides. THOP 1 is associated with important biological processes such as metabolism and neurodegenerative diseases, among others. The
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Celecoxib attenuates neuroinflammation, reactive astrogliosis and promotes neuroprotection in young rats with experimental hydrocephalus J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-09-28 Maurício Dutra, Stephanya Covas da Silva, Pâmella da Silva Beggiora Marques, Izadora Oliveira Amaral, Stephanie Naomi Funo de Souza, Luiz Antônio Dutra, Marcelo Volpon Santos, Hélio Rubens Machado, Luiza da Silva Lopes
Hydrocephalus is a neurological condition with altered cerebrospinal fluid flow (CSF). The treatment is surgical and the most commonly used procedure is ventricle-peritoneal shunt. However, not all patients can undergo immediate surgery or achieve complete lesion reversal. Neuroprotective measures are valuable in such cases. It was evaluated whether the use of celecoxib, a selective inhibitor of COX-2
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Localization and neurochemical identity of alpha1-adrenergic receptor-containing elements in the mouse locus coeruleus J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-09-28 Zachary N.M. Luyo, Abigail B. Lawrence, Theodore G. Stathopoulos, Darlene A. Mitrano
The locus coeruleus (LC) is the major source for norepinephrine (NE) in the brain and projects to areas involved in learning and memory, reward, arousal, attention, and autonomic functions related to stress. There are three types of adrenergic receptors that respond to NE: alpha1-, alpha2-, and beta-adrenergic receptors. Previous behavioral studies have shown the alpha1-adrenergic receptor (α1AR) to
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Activation patterns of dopaminergic cell populations reflect different learning scenarios in a cichlid fish, Pseudotropheus zebra J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-09-16 Calvo Roberta, Schluessel Vera, Hofmann Hans A, Hofmann Michael H
Dopamine is present in all vertebrates and the functional roles of the subsystems are assumed to be similar. Whereas the effect of dopaminergic modulation is well investigated in different target systems, less is known about the factors that are causing the modulation of dopaminergic cells. Using the zebra mbuna, Pseudotropheus zebra, a cichlid fish from Lake Malawi as a model system, we investigated
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Neurobiological and pathophysiological concepts of Christfried Jakob (1866–1956) on language and aphasia: An English translation of two communications [1910,1932] and a modern perspective J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-09-17 Maria E. Vasilopoulou, Lazaros C. Triarhou
The aim of the present article is to preserve, in English translation, two historical communications on aphasia and the pathophysiology of language by the neurobiologist Christfried Jakob (1866–1956) of Buenos Aires, and to place them in a modern perspective. The morphofunctional basis of human language and its pathology occupied Jakob’s mind over three decades. His synthetic conclusions were based
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Cladribine induces apoptosis, neuroinflammation, mitochondrial oxidative stress, tau phosphorylation and Aβ (1–42) pathway in the hippocampus: An in vivo approach J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-09-13 Khadga Raj Aran, G.D. Gupta, Shamsher Singh
Cladribine is a purine nucleoside found to enhance toxic amyloid protein and cause memory impairment. Patients following chemotherapy treatment commonly suffer from cognitive deficits more prevalent in the elderly than adults. A previous research study revealed that cladribine has a high affinity to the brain, increases the level of amyloid precursor protein, and results in learning deficits. The study
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The potential effect of salvianolic acid B against rat ischemic brain injury in combination with mesenchymal stem cells J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-09-12 Minli Yan, Zheming Li, Shijie Dai, Shouye Li, Pingping Yu
Background Mesenchymal stem cells (MSCs) and Salvianolic acid B (SAB) are known to exert potent anti-inflammatory and anti-oxidative properties. But the effect of SAB and MSCs combination treatment on the cerebral ischemia/reperfusion injury (CI/RI) is not clear. Methods After the CI/RI animal model established, rats were administered with MSCs and SAB individually or combination treatment. To evaluate
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Gelatin/polyethylene glycol-loaded magnesium hydroxide nanocomposite to attenuate acetylcholinesterase, neurotoxicity, and activation of GPR55 protein in rat models of Alzheimer's disease J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-09-12 Manickam Rajkumar, Sundarraj Navaneethakrishnan, Sundarapandian Muthukumar, Ramasundaram Thangaraj, Magudeeswaran Sivanandam, Karuppaiya Vimala, Soundarapandian Kannan
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Exploring the effects of embryonic and neonatal exposure to lipopolysaccharides on oligodendrocyte differentiation in the rat hippocampus and the protective effect of alpha-glycosyl isoquercitrin J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-09-09 Hiromu Okano, Ryota Ojiro, Xinyu Zou, Qian Tang, Shunsuke Ozawa, Mihoko Koyanagi, Robert R. Maronpot, Toshinori Yoshida, Makoto Shibutani
This study compared the effects of embryonic and neonatal lipopolysaccharides (LPS) exposure (E-LPS and N-LPS) on oligodendrocyte (OL) differentiation in the hippocampus of male rats and explored the protective effect of the antioxidant alpha-glycosyl isoquercitrin (AGIQ). Using SD rats, LPS exposure occurred either intraperitoneally in dams between gestational days 15 and 16 (50 µg/kg body weight/time)
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GABA-immunoreactive neurons in the Central Nervous System of the viviparous teleost Poecilia sphenops J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-09-09 Achyutham Hotha, C.B. Ganesh
Gamma-aminobutyric acid (GABA) functions as the primary inhibitory neurotransmitter within the central nervous system (CNS) of vertebrates. In this study, we examined the distribution pattern of GABA-immunoreactive (GABA-ir) cells and fibres in the CNS of the viviparous teleost Poecilia sphenops using immunofluorescence method. GABA immunoreactivity was seen in the glomerular, mitral, and granular
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Dendritic reorganization in the hippocampus, anterior temporal lobe, and frontal neocortex of lithium-pilocarpine induced Status Epilepticus (SE) J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-08-31 Vivek Dubey, Avishek Roy, Aparna Banerjee Dixit, Manjari Tripathi, Shivam Pandey, Suman Jain, P.Sarat Chandra, Jyotirmoy Banerjee
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Aerobic exercise training reduces deep-frying oil-induced apoptosis of hippocampal tissue by reducing oxidative stress in male rats J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-08-29 Sina Nikbin, Gita fardad, Sara Yazdi, Marzieh Hosseini Bahman, Parvaneh Ettefagh, Fatemeh Khalegi, Mino Molaei, Kamal Azizbeigi, Myriam Guerra-Balic, Joel Montané, Mehdi Zargani, Mohammad Ali Azarbayjani
Deep-frying oil (DFO) contains high amounts of free radicals, and consuming foods prepared with this method causes damage to nervous tissue due to oxidative stress (OS). Since moderate-intensity aerobic exercise training (AT) reduces OS, the current search investigated the effects of AT on OS, apoptosis, and neurogenesis markers in the hippocampal tissue of DFO-fed rats. Eighteen Wistar male rats (200–280
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Chitosan biomaterial enhances the effect of OECs on the inhibition of sciatic nerve injury-induced neuropathic pain J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-08-25 Jia-ling Hu, Hong-liang Luo, Ji-peng Liu, Cheng Zuo, Yong-sheng Xu, Xiao Feng, Wen-jun Zhang
Neuropathic pain is a common symptom experienced by most clinical diseases at different levels, and its treatment has always been a clinical difficulty. Therefore, it is particularly important to explore new and effective treatment methods. The role of olfactory ensheathing cells (OECs) in nerve injury and pain is recognized by different studies. Our previous study found that transplantation of OECs
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Maternal diabetes decreases the expression of α2-adrenergic and M2 muscarinic receptors in the visual cortex of male rat neonates J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-08-22 Javad Bagheri, Somaye Fallahnezhad, Nasim Alipour, Hamideh Babaloo, Fatemeh Tahmasebi, Hamed Kheradmand, Ghasem Sazegar, Hossein Haghir
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Isoflurane-induced reduction in neurogenesis derived from the tertiary dentate matrix J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-08-17 Xin-Li Xiao, Da-Meng Pan, Zhe-Qian Zhang, Tao Wang, Ding-Hui Li, Chu-Tong Zhang, Le-Fan Liu, Yu Chen, Shu-Nan Yang, Jing Tan, Guan-Ling Fu, Yan-Bing Ma, Xiao-Lin Wu, Jin-Song Zhou, Feng Wu, Kai-Wei Si, Jian-Xin Liu
Anesthetics-induced disruption of dentate neurogenesis in the young brain is strongly suggested to contribute to delayed neurocognitive deficit. In postnatal rodents, the neurogenesis of the dentate gyrus (DG) is sequentially derived from the secondary dentate matrix, tertiary dentate matrix and subgranular zone (SGZ). However, the effects of anesthetics on the dentate neurogenesis derived from specific
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Changes in hypothalamic mu-opioid receptor expression following acute olanzapine treatment in female rats: Implications for feeding behavior J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-08-07 Maiken Krogsbaek, Nick Yao Larsen, Anne M. Landau, Connie Sanchez, Jens Randel Nyengaard
Advances have been made in recent years in using opioid receptor antagonists as an adjunct therapy to psychotropic medication to reduce debilitating weight gain and metabolic adverse effects associated with in particular second generation antipsychotics. However, it is unknown whether second generation antipsychotics produce a change in opioid receptor expression in the brain. The present study investigated
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Sex-dependent endozepinergic regulation of ventromedial hypothalamic nucleus glucose counter-regulatory neuron aromatase protein expression in the adult rat J. Chem. Neuroanat. (IF 2.8) Pub Date : 2023-08-03 A.S.M. Hasan Mahmood, Sagor C. Roy, Jérôme Leprince, Karen P. Briski
The hypothalamic brain cell types that produce estradiol from testosterone remain unclear. Aromatase inhibition affects ventromedial hypothalamic nucleus (VMN) glucose-stimulatory nitric oxide (NO) and glucose-inhibitory γ-aminobutyric acid (GABA) transmission during insulin (INS)-induced hypoglycemia (IIH). Pure GABA and NO nerve cell samples acquired by laser-catapult-microdissection from consecutive