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Recognition and Management of Delirium in the Neonatal Intensive Care Unit: Case Series From a Single-Center Level IV Intensive Care Unit J. Child Neurol. (IF 1.9) Pub Date : 2024-04-17 Stacey Dornette, Stephen Deptola, Brianna Hemmann, Charu Venkatesan, DonnaMaria E. Cortezzo
Delirium often goes unrecognized in neonates and children because of lack of experience in evaluating behavior and cognition, insufficient awareness of the prevalence, and nondistinctive symptoms in this population. Although there are increasing reports of the presence of delirium in neonates, there are little data to guide the pharmacologic treatment in this population. In this retrospective single-center
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Brain Volumes in Opsoclonus-Myoclonus Ataxia Syndrome: A Longitudinal Study J. Child Neurol. (IF 1.9) Pub Date : 2024-03-28 Montaha Almudhry, Matthias W. Wagner, Giulia Longoni, Carmen Yea, Logi Vidarsson, Birgit Ertl-Wagner, E. Ann Yeh
IntroductionLittle is known about the longitudinal trajectory of brain growth in children with opsoclonus-myoclonus ataxia syndrome. We performed a longitudinal evaluation of brain volumes in pediatric opsoclonus-myoclonus ataxia syndrome patients compared with age- and sex-matched healthy children.Patients and MethodsThis longitudinal case-control study included brain magnetic resonance imaging (MRI)
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Characterization of Fine Motor and Visual Motor Skills in Aicardi-Goutières Syndrome J. Child Neurol. (IF 1.9) Pub Date : 2024-03-27 Stacy V. Cusack, Francesco Gavazzi, Isabella Peixoto de Barcelos, Nicholson B. Modesti, Sarah Woidill, Brielle Formanowski, Sara B. DeMauro, Scott Lorch, Ariel Vincent, Abbas F. Jawad, Timothy Estilow, Allan M. Glanzman, Adeline Vanderver, Laura A. Adang
Aicardi-Goutières syndrome is a genetic inflammatory disorder resulting in dispersed neurologic dysfunction. Despite a recognition of overall motor impairment, fine and visual motor skills are undercharacterized. We hypothesize that there is a spectrum of fine and visual motor skills in the Aicardi-Goutières syndrome population as captured by a standard outcome measure, the Peabody Developmental Motor
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Yield and Utility of Routine Epilepsy Panel Genetic Testing Among Young Patients With Seizures J. Child Neurol. (IF 1.9) Pub Date : 2024-03-26 Emily Grew, Mayuri Reddy, Hayley Reichner, Jinsoo Kim, Misbah Salam, Anjum Hashim
Objective: We examined the yield of routine epilepsy panel genetic testing in pediatric patients. Methods: We retrospectively reviewed epilepsy genetic panel results routinely performed in the hospital or clinic on patients <8 years old from July 2021 to July 2023. We evaluated demographics, family history, seizure type, severity, and frequency, development, tone and movement abnormalities, dysmorphism
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In Support of Single-Payer Health Care J. Child Neurol. (IF 1.9) Pub Date : 2024-03-26 Jay Desai, Kiarash Sadrieh
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New-Onset Vision Impairment in Children: Magnetic Resonance Imaging Findings by Age Groups J. Child Neurol. (IF 1.9) Pub Date : 2024-03-20 Esra Çıvgın, Semra Duran, Izzet Selçuk Parlak, Başak Gülleroğlu, İnci Elif Erbahçeci Timur, Özge Dedeoğlu, Ayşe Seçil Yücel Ekşioğlu
IntroductionNon-traumatic visual impairment is rare in the pediatric population, but early diagnosis and treatment of the cause is crucial to prevent long-term consequences affecting children's neurocognitive development. The authors aim to determine the most common causes of non-traumatic visual impairment in pediatric patients according to age groups by magnetic resonance imaging (MRI).MethodsImages
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Clearance for Driving in Genetic Generalized Epilepsy J. Child Neurol. (IF 1.9) Pub Date : 2024-03-19 Jay Desai, Kiarash Sadrieh, Eesha Singh
A key aspect of management of genetic generalized epilepsy involves assessing seizure control and deciding suitability for driving motor vehicles. We surveyed child neurologists and pediatric epileptologists on key questions that practitioners should ask prior to providing clearance for driving. The results showed a wide variability of practice among responders. We propose a likely appropriate process
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Rare Cases of Pseudomonas aeruginosa Meningitis in Children: 10-Year Experience in a Single Center J. Child Neurol. (IF 1.9) Pub Date : 2024-03-15 Lijun Liu, Lvchang Zhu, Chanchan Hu, Shuzhen Zhu, Sheng Ye
ObjectiveThe primary objective was to elucidate the epidemiologic characteristics, risk determinants, and clinical outcomes associated with Pseudomonas aeruginosa–induced meningitis.MethodsAll cases of meningitis caused by Pseudomonas aeruginosa that were treated at the hospital between 2012 and 2022 were retrospectively analyzed and detailed.ResultsDuring a 10-year period, only 10 patients satisfied
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Pediatric Subacute Sclerosing Panencephalitis: A Narrative Review on Measles and the Future of Vaccination J. Child Neurol. (IF 1.9) Pub Date : 2024-03-13 Samia Aziz Sulaiman, Nilofar M. Vora, Kusumita Chhabra, Muhammad Arsalan Bashir, Zainab Awan
Subacute sclerosing panencephalitis is a rare complication due to persistent measles infection, characterized by cognitive and motor deterioration. Because subacute sclerosing panencephalitis is considered a potentially fatal complication of measles and usually presents in young populations, particularly those with measles infection under the age of 2 years, new approaches to implement vaccination
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Opening Pressure and Post–Lumbar Puncture Headache in Children Undergoing Intrathecal Baclofen Trial J. Child Neurol. (IF 1.9) Pub Date : 2024-02-29 Amanda E. Summers, Jenny L. Wilson
Aims: Post–lumbar puncture headache occurs in 5% to 12% of children. The purpose of this study was to determine the frequency and predictors of post–lumbar puncture headache in children with hypertonia undergoing lumbar puncture for intrathecal baclofen trial. Methods: This was a retrospective single-center review of all 43 children (<18 years) with hypertonia and/or dyskinesia undergoing intrathecal
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Stereotactic Awake Basal Ganglia Electrophysiological Recording and Stimulation (SABERS): A Novel Staged Procedure for Personalized Targeting of Deep Brain Stimulation in Pediatric Movement and Neuropsychiatric Disorders J. Child Neurol. (IF 1.9) Pub Date : 2024-02-27 Mark A. Liker, Terence D. Sanger, Jennifer A. MacLean, Jaya Nataraj, Enrique Arguelles, Mark Krieger, Aaron Robison, Joffre Olaya
Selection of targets for deep brain stimulation (DBS) has been based on clinical experience, but inconsistent and unpredictable outcomes have limited its use in patients with heterogeneous or rare disorders. In this large case series, a novel staged procedure for neurophysiological assessment from 8 to 12 temporary depth electrodes is used to select targets for neuromodulation that are tailored to
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The Use of Botulinum Toxin Type A in Medically Refractory Pediatric Patients With Chronic Daily Headaches and Its Impact on the Quality of Life J. Child Neurol. (IF 1.9) Pub Date : 2024-02-14 Asra Akbar, Jenna Ford, Sandeep Tripathi
Background: Chronic migraine in children has been a challenging condition to treat, prompting the investigation of alternative therapies. This retrospective single-center chart review aimed to evaluate the efficacy and safety of Botox injections for managing chronic migraine in children. Methods: The study included children with chronic daily headaches and chronic migraine who were medically refractory
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Ketogenic Diet: Parental Experiences and Expectations J. Child Neurol. (IF 1.9) Pub Date : 2024-02-05 Elizabeth Orr, Robyn Whitney, Nandini Nandeesha, Eric H. Kossoff, Rajesh RamachandranNair
BackgroundThe ketogenic diet may be difficult for some patients and their families to implement and can impact physical, emotional, and social well-being.MethodsThrough principles of fundamental qualitative description, we completed an exploratory study on parents’ experiences and expectations on the use and efficacy of the ketogenic diet for children with medically refractory epilepsy.ResultsSeventeen
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Cow's Milk Anemia in Childhood Manifesting as Severe Cerebral Venous Sinus Thrombosis J. Child Neurol. (IF 1.9) Pub Date : 2024-01-24 Kristin Maher, Catherine Amlie-Lefond
We describe a series of 7 toddler-aged children with iron deficiency anemia from excessive cow's milk consumption who presented with cerebral venous sinus thrombosis and no other identifiable risk factors for thrombosis. The deep venous system was involved in 6 patients, 6 had venous infarcts, and 5 have significant neurocognitive sequelae.
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Glial Fibrillary Acidic Protein (GFAP) Astrocytopathy: An Emerging Cause of Meningoencephalomyelitis in Children and Adolescents. J. Child Neurol. (IF 1.9) Pub Date : 2023-11-20 Prayerna Uppal,Jacklyn Smith,Carlos Castillo-Pinto,Elizabeth M Wells,Anuj Jayakar,Dana Harrar
Introduction: We describe 5 children with GFAP astrocytopathy with the goal of further characterizing this rare form of meningoencephalomyelitis. Methods: Retrospective chart review of patients diagnosed with GFAP astrocytopathy between 2019 and 2021. Results: Patients were 8-17 years old, and all were male. Fever, headache, and vomiting were common presenting symptoms, and weakness, tremor, and ataxia
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Acquisition and Loss of Developmental Milestones and Time to Disease-Related Outcomes in Cerebral Alexander Disease. J. Child Neurol. (IF 1.9) Pub Date : 2023-11-03 Joshua Joung,Kathryn Gallison,John Jack Sollee,Nicholas Vigilante,Hannah Cooper,Geraldine W Liu,Lance Ballester,Walter Faig,Amy T Waldman
Objective: To determine the ages at acquisition of developmental milestones, loss of motor function, and clinical symptoms in Alexander disease. Methods: Patients with confirmed cerebral Alexander disease were included. Data abstraction of developmental and disease-specific milestones was performed from medical records, physical exams, and questionnaires. Mixed effects logistic regression was used
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Gait Abnormalities in Children with Phelan-McDermid Syndrome. J. Child Neurol. (IF 1.9) Pub Date : 2023-10-18 Yitzchak Frank,Tess Levy,Reymundo Lozano,Kate Friedman,Slayton Underwood,Ana Kostic,Hannah Walker,Alexander Kolevzon
Background: Phelan-McDermid syndrome is a genetic disorder caused by haploinsufficiency of the SHANK3 gene on chromosome 22q13.3 and is characterized by autism spectrum disorder, intellectual disability, speech and language abnormalities, hypotonia, and mild dysmorphic features. Early literature in Phelan-McDermid syndrome did not include gait abnormalities as part of the syndrome although recent prospective
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Socioecologic Factors Associated With Obesity in Adolescents With Epilepsy in the United States. J. Child Neurol. (IF 1.9) Pub Date : 2023-10-03 Acadia W Buro,Rachel Sauls,Abraham Salinas-Miranda,Russell S Kirby
BACKGROUND Obesity among youth with epilepsy has multifactorial etiology, yet socioecologic obesity risk factors (eg, neighborhood factors) have not been examined in this population. This study examined (1) the prevalence of obesity adjusting for relevant covariates and (2) socioecologic correlates of obesity in adolescents with epilepsy aged 10-17 years. METHODS This cross-sectional study used 2017-2018
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Differentiating Genetic Forms of Pontocerebellar Hypoplasia From Acquired Lesions Resembling Pontocerebellar Hypoplasia: Clinical, Neurodevelopmental, and Imaging Insight From 19 Extremely Premature Patients. J. Child Neurol. (IF 1.9) Pub Date : 2023-09-20 Audrey Riquet,François Quesque,Marie-Laure Charkaluk,Laure Desnoulez,Dorothée Neut,Sylvie Joriot,Odile Goze,Gustavo Soto Ares,Wael Yacoub
It is well established that extreme prematurity can be associated with cerebellar lesions potentially affecting the neurologic prognosis. One of the commonly observed lesions in these cases is pontocerebellar hypoplasia resulting from prematurity, which can pose challenges in distinguishing it from genetically caused pontocerebellar hypoplasia. This confusion leads to unacceptable and prolonged diagnostic
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Methodology of a Natural History Study of a Rare Neurodevelopmental Disorder: Alternating Hemiplegia of Childhood as a Prototype Disease. J. Child Neurol. (IF 1.9) Pub Date : 2023-09-20 Shital H Patel,Eleni Panagiotakaki,Maria T Papadopoulou,Carmen Fons,Elisa De Grandis,Aikaterini Vezyroglou,Simona Balestrini,Hwanhee Hong,Beiyu Liu,Lyndsey Prange,Alexis Arzimanoglou,Rosaria Vavassori,Mohamad A Mikati
Here, we describe the process of development of the methodology for an international multicenter natural history study of alternating hemiplegia of childhood as a prototype disease for rare neurodevelopmental disorders. We describe a systematic multistep approach in which we first identified the relevant questions about alternating hemiplegia of childhood natural history and expected challenges. Then
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Diagnostic Performance of 3D-NERVE as an Adjunct to Electromyography for the Assessment of Brachial Plexus Injury in Infants. J. Child Neurol. (IF 1.9) Pub Date : 2023-09-12 Leilei Zhao,Jianshe Zhao,Changyou Ma,Yi Lu,Chunhua Dong
Objective: This study aimed to explore diagnostic performance of 3D-NERVE as an adjunct to electromyography for the assessment of brachial plexus injury in infants. Methods: Imaging of infants with brachial plexus injury using 3D-NERVE and/or 3D-STIR from 2019 to 2022 were reviewed. Images were evaluated between the 2 sequences for nerve-to-fat ratio, nerve-to-muscle ratio, muscle-to-fat ratio, fat
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A Case Series of Transgender and Gender-Nonconforming Patients in a Pediatric Functional Neurologic Disorder Clinic. J. Child Neurol. (IF 1.9) Pub Date : 2023-09-10 Alison Wilkinson-Smith,Mackenzie P Lerario,Kelsey N Klindt,Jeff L Waugh
Youth who identify as transgender and gender nonconforming (TGNC) are at increased risk of anxiety, depression, bullying, and loss of social and family support. These factors may increase the risk of developing functional neurologic disorder (FND). If the risk of FND is increased in TGNC youth, then identifying which youth are at increased risk, and the particular times when risk is increased, may
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Secondary Intracranial Hypertension in Pediatric Lyme Meningitis. J. Child Neurol. (IF 1.9) Pub Date : 2023-09-10 James D Rogers,Catherine O Jordan,Hilliary E Inger,Shawn C Aylward
Lyme disease is the most common vector-borne disease in the United States and has been associated with secondary intracranial hypertension. We reviewed 11 pediatric patients with Lyme-associated secondary intracranial hypertension. All patients presented with headache, ten had papilledema, 7 with a rash, and 5 with a cranial nerve palsy. All patients were treated with acetazolamide, and 3 received
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Continuous Electroencephalography (EEG) Protocol Improves Seizure Detection in Children on Extracorporeal Membrane Oxygenation. J. Child Neurol. (IF 1.9) Pub Date : 2023-08-25 Danielle deCampo,Khalil S Husari,Melania M Bembea,Christa W Habela,Eva K Ritzl
BACKGROUND / OBJECTIVE Seizures are a complication for pediatric patients requiring extracorporeal membrane oxygenation (ECMO). There are no standardized guidelines regarding continuous electroencephalography (EEG) monitoring to detect seizures in these patients, and the impact of protocolized monitoring has not been evaluated. Here we examined the effects of continuous EEG protocol implementation
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Clinical Features and a Prediction Nomogram for Prognosis in Children with Escherichia coli Meningitis. J. Child Neurol. (IF 1.9) Pub Date : 2023-08-13 Lingyu Zhang,Wenjie Li,Xiaoling Peng,Li Jiang,Yue Hu
BACKGROUND We aimed to build a prediction nomogram for early prediction of poor prognosis in children with Escherichia coli meningitis and analyzed the course of treatment and discharge criteria. METHODS Eighty-seven pediatric patients with E coli meningitis were retrospectively recruited from the Children's Hospital of Chongqing Medical University between June 2012 and November 2021. Univariate analysis
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Acquired Demyelinating Syndromes of the Central Nervous System in Children: The Importance of Regular Follow-up in the First Year After Onset. J. Child Neurol. (IF 1.9) Pub Date : 2023-08-13 Carlotta Canavese,Irene Favole,Rossella D'Alessandro,Fabiana Vercellino,Amanda Papa,Barbara Podestà,Francesca Longaretti,Francesca Brustia,Sara Rampone,Francesca Benedini,Mariachiara Giraudo,Aba Tocchet
AIM We reviewed the clinical features of a sample of pediatric acquired demyelinating syndromes with the purpose of determining the appropriate protocol for follow-up after the first episode. METHODS A multicenter retrospective observational study was conducted on a cohort of 40 children diagnosed with a first episode of acquired demyelinating syndrome over the period 2012-2021. Patients were evaluated
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Temporal Evolution of Signal Alterations in the Deep Gray Nuclei in term Neonates With Hypoxic-Ischemic Brain Injury: A Comprehensive Review. J. Child Neurol. (IF 1.9) Pub Date : 2023-07-27 Ebinesh Arulnathan,Alpana Manchanda,Rashmi Dixit,Ajay Kumar
The deep gray nuclei are paired interconnected gray nuclei comprising the basal ganglia and thalami. Injury to the deep gray nuclei secondary to hypoxic-ischemic injury is associated with poor short- and long-term clinical outcomes. The signal changes following hypoxic-ischemic injury are dynamic and evolve over a period of time from injury to resolution. Radiologically relevant events following hypoxic-ischemic
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Exploration of Gross Motor Function in Aicardi-Goutières Syndrome. J. Child Neurol. (IF 1.9) Pub Date : 2023-07-27 Francesco Gavazzi,Allan M Glanzman,Sarah Woidill,Brielle Formanowski,Agrani Dixit,David Isaacs,Tracy Kornafel,Elizabeth Ballance,Samuel R Pierce,Nicholson Modesti,Isabella Barcelos,Stacy V Cusack,Amanda K Jan,Zaida Flores,Omar Sherbini,Ariel Vincent,Russell D'Aiello,Scott A Lorch,Sara B DeMauro,Abbas Jawad,Adeline Vanderver,Laura Adang
Background: Aicardi-Goutières syndrome (AGS) is a rare genetic disorder characterized by a spectrum of motor abilities. While the Aicardi-Goutières syndrome severity score favors severely impacted individuals, there is an unmet need to define tools measuring function across the Aicardi-Goutières syndrome spectrum as potential outcome assessments for future clinical trials. Methods: Gross Motor Function
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Autism Spectrum Disorder in Children With Perinatal Ischemic Stroke Varies by Stroke Type. J. Child Neurol. (IF 1.9) Pub Date : 2023-07-27 Clara M Wu,Bo Zhang,Cameron C Trenor,Michael J Rivkin,Amy Danehy,Laura L Lehman
Background and Objectives: Perinatal stroke leads to significant morbidity over a child's lifetime, including diagnosis of various neurodevelopmental disorders. Specific studies examining the prevalence of autism spectrum disorder in children with perinatal stroke are scarce. Following the clinical observation of autism spectrum disorder in a pediatric referral stroke center, we evaluated the rate
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Acute Diffusion-Weighted Imaging Signaling Severe Periventricular Leukomalacia in Preterm Infants: Case Report and Review of Literature. J. Child Neurol. (IF 1.9) Pub Date : 2023-07-18 Aisling A Garvey,Mohamed El-Dib,P Ellen Grant,Simon M Manning,Joseph J Volpe,Terrie E Inder
Introduction: Periventricular leukomalacia occurs in up to 25% of very preterm infants resulting in adverse neurodevelopmental outcomes. In its acute phase, periventricular leukomalacia is clinically silent. Although ultrasonography is widely available, its sensitivity in the early detection of periventricular leukomalacia is low. Case Report and Published Literature: We identified a preterm infant
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Outcome of Absence Epilepsy With Onset at 8-11 Years of Age: Watershed Ages When Syndromes Overlap. J. Child Neurol. (IF 1.9) Pub Date : 2023-07-17 Anita N Datta,Jacqueline Crawford,Laura Wallbank,Peter K H Wong
Introduction: Absence seizures occur in various epilepsy syndromes, including childhood and juvenile absence epilepsy and juvenile myoclonic epilepsy. When children present with absence seizures at ages when syndromes overlap, initial syndrome designation is not always possible, making early prognostication challenging. For these children, the study objective is to determine clinical and initial e
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Gross Motor Function in Pediatric Onset TUBB4A-Related Leukodystrophy: GMFM-88 Performance and Validation of GMFC-MLD in TUBB4A. J. Child Neurol. (IF 1.9) Pub Date : 2023-07-17 Francesco Gavazzi,Virali Patel,Brittany Charsar,Allan Glanzman,Jacqueline Erler,Anjana Sevagamoorthy,Emma McKenzie,Tracy Kornafel,Elizabeth Ballance,Samuel R Pierce,Michelle Teng,Brielle Formanowski,Sarah Woidill,Justine Shults,Evangeline Wassmer,Davide Tonduti,Francesca Magrinelli,Geneviève Bernard,Marjo Van Der Knaap,Nicole Wolf,Laura Adang,Adeline Vanderver
TUBB4A pathogenic variants are associated with a spectrum of neurologic impairments including movement disorders and leukodystrophy. With the development of targeted therapies, there is an urgent unmet need for validated tools to measure mobility impairment. Our aim is to explore gross motor function in a pediatric-onset TUBB4A-related leukodystrophy cohort with existing gross motor outcome tools.
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Safety of Diazepam Nasal Spray in Pediatric Patients With Developmental Epileptic Encephalopathies: Results From a Long-term Phase 3 Safety Study. J. Child Neurol. (IF 1.9) Pub Date : 2023-07-16 Daniel Tarquinio,James W Wheless,Eric B Segal,Sunita N Misra,Adrian L Rabinowicz,Enrique Carrazana
Pediatric developmental epileptic encephalopathies are often refractory to treatment despite stable antiseizure therapy. The safety profile of diazepam nasal spray (Valtoco) as rescue therapy for seizure clusters was described in a long-term safety study. This post hoc analysis assessed safety and effectiveness within a subpopulation of patients with developmental epileptic encephalopathies. Of 163
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Use of Complementary and Alternative Medicine in Children with Neuromuscular Disorders Followed at Penn State Health Pediatric Muscular Dystrophy Association Care Center Clinic. J. Child Neurol. (IF 1.9) Pub Date : 2023-07-16 Rea Mittal,Caroline Maltese,Elizabeth Bolt,Dustin Paul,Gayatra Mainali,Sunil Naik,Sita Paudel,Erik Lehman,Ashutosh Kumar
The exact prevalence of complementary and alternative medicine (CAM) use is not known in pediatric patients with neuromuscular diseases followed by any of the 150 Muscular Dystrophy Association (MDA) Care Center Clinics nationwide. This study describes the prevalence and variety of CAM usage in this population, while also assessing the prevalence of caregiver disclosure of CAM use and caregiver perception
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Caregivers' Perspectives on the Impact of Cannabidiol (CBD) Treatment for Dravet and Lennox-Gastaut Syndromes: A Multinational Qualitative Study. J. Child Neurol. (IF 1.9) Pub Date : 2023-07-16 Jade Marshall,Hanna Skrobanski,Lisa Moore-Ramdin,Klaudia Kornalska,Paul Swinburn,Sally Bowditch
OBJECTIVE To increase understanding of the impact of cannabidiol (CBD) on outcomes beyond seizure control among individuals with Dravet syndrome or Lennox-Gastaut syndrome. METHODS Qualitative interviews were conducted with caregivers of individuals with Dravet syndrome or Lennox-Gastaut syndrome treated with plant-derived, highly purified CBD medicine (Epidiolex in the USA; Epidyolex in Europe; 100 mg/mL
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Corticomuscular Coherence in Children with Unilateral Cerebral Palsy: A Feasibility and Preliminary Protocol Study. J. Child Neurol. (IF 1.9) Pub Date : 2023-07-14 Rachana R Gangwani,Jasper I Mark,Rachel M Vaughn,Holly Holland,Deborah E Thorpe,Joshua J Alexander,Swati M Surkar,Jessica M Cassidy
Objective This study assessed the feasibility of corticomuscular coherence measurement during a goal-directed task in children with unilateral cerebral palsy while establishing optimal experimental parameters. Methods Participants (Manual Ability Classification System levels I-III) completed a submaximal isometric goal-directed grip task during simultaneous electroencephalography and electromyography
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Safety and Efficacy of Botulinum Toxin Type A in Children With Spastic Cerebral Palsy Aged <2 Years: A Systematic Review. J. Child Neurol. (IF 1.9) Pub Date : 2023-07-10 Hongyi Yang,Shiwei Chen,Jiaqi Shen,Yijing Chen,Minlin Lai,Linfei Chen,Suzhen Fang
In this study, we reviewed the safety and efficacy of botulinum toxin type A (BoNT-A) injection with respect to motor development in children with spastic cerebral palsy aged <2 years. Randomized controlled trials of BoNT-A published between July 1993 and May 2021 were searched in PubMed, WANFANG, CNKI (Chinese National Knowledge Infrastructure), and Cochrane Library Central Register of Controlled
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High Prevalence of Collagenopathies in Preterm- and Term-Born Children With Periventricular Venous Hemorrhagic Infarction. J. Child Neurol. (IF 1.9) Pub Date : 2023-07-10 Norman Ilves,Sander Pajusalu,Tiina Kahre,Rael Laugesaar,Ustina Šamarina,Dagmar Loorits,Pille Kool,Pilvi Ilves
INTRODUCTION The aim of this study was to evaluate genetic risk factors in term-born children with antenatal periventricular hemorrhagic infarction (PVHI), presumed antenatal periventricular venous infarction and periventricular hemorrhagic infarction in preterm neonates. METHODS Genetic analysis and magnetic resonance imaging were performed in 85 children: term-born children (≥36 gestational weeks)
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Clinical Profile, Follow-up, and Role of Neuroimaging in Pediatric Guillain-Barré Syndrome in the COVID Era: An Ambispective Study. J. Child Neurol. (IF 1.9) Pub Date : 2023-06-26 Lokesh Saini,Deepthi Krishna,Pradeep Kumar Gunasekaran,Sarbesh Tiwari,Prawin Kumar,Jagdish Prasad Goyal,Daisy Khera,Bharat Choudhary,Siyaram Didel,Ravi Gaur,Veena Laxmi,Samhita Panda,Kuldeep Singh
Background: To define the varied presentations of Guillain-Barré syndrome in children in the COVID era and 6 months' follow-up outcome. Methods: Ambispective study of 15 months' duration involving children with Guillain-Barré syndrome aged 1 month to 18 years at a tertiary care pediatric hospital. They were categorized into groups A and B based on COVID-19 serology testing. Hughes Disability Scale
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Electroencephalographic (EEG) Biomarkers in Genetic Neurodevelopmental Disorders. J. Child Neurol. (IF 1.9) Pub Date : 2023-06-01 Kimberly Goodspeed,Dallas Armstrong,Alison Dolce,Patricia Evans,Rana Said,Peter Tsai,Deepa Sirsi
Collectively, neurodevelopmental disorders are highly prevalent, but more than a third of neurodevelopmental disorders have an identifiable genetic etiology, each of which is individually rare. The genes associated with neurodevelopmental disorders are often involved in early brain development, neuronal signaling, or synaptic plasticity. Novel treatments for many genetic neurodevelopmental disorders
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The Experience of Parents of Children With Genetically Determined Leukoencephalopathies With the Health Care System: A Qualitative Study. J. Child Neurol. (IF 1.9) Pub Date : 2023-05-24 Pouneh Amir Yazdani,Marie-Lou St-Jean,Sara Matovic,Aaron Spahr,Luan T Tran,Renée-Myriam Boucher,Chantal Poulin,Bradley Osterman,Myriam Srour,Bernard Rosenblatt,Sébastien Chénier,Jean-Francois Soucy,Anne-Marie Laberge,Maria Daniela D'Agostino,Cam-Tu Emilie Nguyen,Maxime Morsa,Geneviève Bernard
Parents of children with genetically determined leukoencephalopathies play a major role in their children's health care. We sought to gain a better understanding of their experience with the public health care system in Quebec, Canada, to obtain suggestions for improving their services, and to identify modifiable factors to improve their quality of life. We conducted interviews with 13 parents. Data
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Genetic Testing in Neonatal Hypoxic-Ischemic Encephalopathy. J. Child Neurol. (IF 1.9) Pub Date : 2023-05-24 Shabih Manzar
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Paroxysmal Nonepileptic Events in Children With Epilepsy and Cerebral Palsy. J. Child Neurol. (IF 1.9) Pub Date : 2023-05-18 Monica S Cooper,Michael C Fahey,Charuta Dagia,Dinah Reddihough,Susan M Reid,Mark T Mackay
Objective: To determine the frequency of paroxysmal nonepileptic events in children with cerebral palsy due to brain injury who have epilepsy and to describe the factors associated with paroxysmal nonepileptic events. Methods: Retrospective, population-based study of children from the Victorian CP Register born 1999-2006. Neuroimaging, medical records, electroencephalograms (EEG), and EEG requests
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Sleep Characteristics in Pediatric Anti-N-methyl-d-aspartate (NMDA) Receptor Encephalitis: A Retrospective Cohort Study. J. Child Neurol. (IF 1.9) Pub Date : 2023-05-18 Grace Gombolay,Morgan Morris,Leah Loerinc,Laura Blackwell,Robyn Howarth
Background: Rates of sleep problems in children with anti-N-methyl-d-aspartate (NMDA) receptor encephalitis are unknown. Methods: We used a retrospective observational cohort database of children with a diagnosis of NMDA receptor encephalitis at a single freestanding institution. One-year outcomes were assessed with the pediatric modified Rankin Score (mRS), with 0 to 2 as good and 3 or greater as
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The Gomez-Lopez-Hernandez Syndrome: The Contribution of 2 Hispanic Giants of Pediatric Neurology. J. Child Neurol. (IF 1.9) Pub Date : 2023-05-18 Bao Xin Liang,Enrique Carrazana,Jason Viereck,Kore K Liow
The specialty of Pediatric Neurology emerged during the 20th century, a period in which many neurologists played significant roles in revolutionizing this field. Two acclaimed pediatric neurologists of Hispanic origin, Drs Manual Gomez and Arturo Lopez-Hernandez, made substantial contributions to the literature on pediatric neurology. One of their remarkable contributions was their discovery of a new
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Clinico-Etiologic Profile of Children and Adolescents with Drug-Resistant Epilepsy in a low-Resource Setting: 10 Years' Experience. J. Child Neurol. (IF 1.9) Pub Date : 2023-05-18 Dipti Kapoor,Divyani Garg,Nitya Beriwal,Sidharth,Ashna Kumar,Sharmila B Mukherjee,Harish Kumar Pemde,Suvasini Sharma
Purpose: Nearly 25% to 30% of children with epilepsy develop drug-resistant epilepsy. Etiology of epilepsy, including drug-resistant epilepsy, varies with geographical region. Identifying paucity of etiologic data on drug-resistant epilepsy from our region and similar low-resource settings, we aimed to describe the clinical and etiologic profile of children and adolescents with drug-resistant epilepsy
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Trends in the Epidemiology and Treatment of Pediatric-Onset Multiple Sclerosis in Alberta, Canada. J. Child Neurol. (IF 1.9) Pub Date : 2023-05-18 Camille Yearwood,Colin Wilbur
BACKGROUND Fingolimod became the first disease-modifying therapy approved by Health Canada for pediatric multiple sclerosis in 2018, but the impact of that approval on treatment patterns in Canada is unknown. The aim of this study was to describe trends in the epidemiology and treatment of pediatric-onset multiple sclerosis in Alberta, Canada. METHODS This study entailed a retrospective review of administrative
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Audio or Video? Access to Pediatric Neurology Outpatient Services Varies by the Type of Telehealth, Especially for Black Children J. Child Neurol. (IF 1.9) Pub Date : 2023-05-15 Annette Grefe, Shyh-Huei Chen, Edward H. Ip, Eric Kirkendall, Savithri Nageswaran
BackgroundChildren of minority race/ethnicity face barriers to accessing specialty services. During the COVID pandemic, health insurance companies reimbursed telehealth services. Our objective was ...
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Response to Melatonin Treatment in Children With Autism spectrum Disorder and Relationship to Sleep Parameters and Melatonin Levels. J. Child Neurol. (IF 1.9) Pub Date : 2023-05-16 Elena Martinez-Cayuelas,Milagros Merino-Andreu,Rebeca Losada-Del Pozo,Teresa Gavela-Pérez,Carmen Garcés,Leandro Soriano-Guillén
Melatonin is one of the most used pharmacologic treatments for sleep problems in autism spectrum disorder, though its relationship with circadian and sleep parameters is still not well stablished. A naturalistic study was conducted in children with autism spectrum disorder, previously drug-naïve, before and after treatment with immediate-release melatonin. Circadian rhythms and sleep parameters were
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Meaningful Improvements in Rett Syndrome: A Qualitative Study of Caregivers J. Child Neurol. (IF 1.9) Pub Date : 2023-05-09 Sarah A. McGraw, Constance Smith-Hicks, James Nutter, Jeffrey C. Henne, Victor Abler
BackgroundRett syndrome is a rare neurodevelopmental disorder primarily affecting females. This syndrome is associated with many comorbidities and impairments related to motor function, breathing, ...
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Adolescent Gender Differences in Tic- and Non-Tic-Related Impairments in Tourette Syndrome J. Child Neurol. (IF 1.9) Pub Date : 2023-05-08 Travis R. Larsh, Steve W. Wu, David A. Huddleston, Sean White, Tara D. Lipps, Donald L. Gilbert
We aimed to compare tic- and non-tic-related impairment experienced by adolescent girls and boys (ages 13 through 17) with Tourette syndrome and associations with age. We extracted from the electro...
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Development and Evaluation of a Child Neurology Resident Curriculum for Communication Around Serious Illness J. Child Neurol. (IF 1.9) Pub Date : 2023-05-08 Jan A. Martin, Fiona Sampey, Alison Feldman, Lori Silveira, Craig A. Press, Ricka Messer, Megan Barry, Paritosh Kaul
Background: Communication around serious illness is a core competency for all residencies. One-fifth of neurology residencies have no curriculum. Published curricula use didactics or role-play to a...
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Meaningful Improvements in Rett Syndrome: A Qualitative Study of Caregivers. J. Child Neurol. (IF 1.9) Pub Date : 2023-05-09 Sarah A McGraw,Constance Smith-Hicks,James Nutter,Jeffrey C Henne,Victor Abler
BACKGROUND Rett syndrome is a rare neurodevelopmental disorder primarily affecting females. This syndrome is associated with many comorbidities and impairments related to motor function, breathing, sleep, expressive language, and repetitive hand movements. The Rett Syndrome Behaviour Questionnaire (RSBQ) is one measure used to assess changes in Rett syndrome-related manifestations or core symptoms
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Exploring the Age-Old Question: What Is the Predictive Value of EEG for Future Epilepsy in Children With Complex Febrile Seizures? J. Child Neurol. (IF 1.9) Pub Date : 2023-05-07 Purva R. Choudhari, Andrea Lowden, Alison Dolce
Children with complex febrile seizures (CFS) have increased risk for the development of epilepsy, but varying prognostic value has been ascribed to abnormal post-CFS electroencephalograms (EEGs). W...
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The Spectrum of Pediatric Infection-Associated Intracranial Arteriopathies and Acute Ischemic Stroke at 2 Eastern Indian Tertiary Care Centres J. Child Neurol. (IF 1.9) Pub Date : 2023-05-03 Suman Das, Biman Kanti Ray, Lopamudra Mishra, Kaushani Chatterjee, Gobinda Mondal, Dilip Kumar Paul
IntroductionMajor and minor pediatric infections may cause intracranial arteriopathies, the long-term outcome of which we investigated and identified the factors influencing the progression/resolut...
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Language and Cognitive Outcomes Following Ischemic Stroke in Children With Monolingual and Bilingual Exposure J. Child Neurol. (IF 1.9) Pub Date : 2023-05-03 Kai Ian Leung, Nomazulu Dlamini, Robyn Westmacott, Monika Molnar
AimAlthough many children who experience ischemic stroke come from bilingual backgrounds, it is unclear whether bilingual exposure affects poststroke development. Our research evaluates bilingual a...
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Use of Thalamus L-Sign to Differentiate Periventricular Leukomalacia From Neurometabolic Disorders J. Child Neurol. (IF 1.9) Pub Date : 2023-05-02 Sabahattin Yuzkan, Merve Emecen Sanli, Merve Balci, Pakize Cennetoglu, Ihsan Kafadar, Burak Kocak
PurposeTo assess the diagnostic value of the thalamus L-sign on magnetic resonance imaging (MRI) in distinguishing between periventricular leukomalacia and neurometabolic disorders in pediatric pat...
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Use of Invasive Brain-Computer Interfaces in Pediatric Neurosurgery: Technical and Ethical Considerations J. Child Neurol. (IF 1.9) Pub Date : 2023-04-28 David Bergeron, Christian Iorio-Morin, Marco Bonizzato, Guillaume Lajoie, Nathalie Orr Gaucher, Éric Racine, Alexander G. Weil
Invasive brain-computer interfaces hold promise to alleviate disabilities in individuals with neurologic injury, with fully implantable brain-computer interface systems expected to reach the clinic...