样式: 排序: IF: - GO 导出 标记为已读
-
The spike-timing-dependent plasticity of VIP interneurons in motor cortex Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-19 Amanda R. McFarlan, Connie Guo, Isabella Gomez, Chaim Weinerman, Tasha A. Liang, P. Jesper Sjöström
The plasticity of inhibitory interneurons (INs) plays an important role in the organization and maintenance of cortical microcircuits. Given the many different IN types, there is an even greater diversity in synapse-type-specific plasticity learning rules at excitatory to excitatory (E→I), I→E, and I→I synapses. I→I synapses play a key disinhibitory role in cortical circuits. Because they typically
-
β-carbolines that enhance GABAA receptor response expressed in oligodendrocytes promote remyelination in an in vivo rat model of focal demyelination Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Abraham Jotssel Cisneros-Mejorado, Rainald Pablo Ordaz, Edith Garay, Rogelio O. Arellano
Demyelination is typically followed by a remyelination process through mature oligodendrocytes (OLs) differentiated from precursor cells (OPCs) recruited into the lesioned areas, however, this event usually results in uncompleted myelination. Potentiation of the remyelination process is an important target for designing effective therapeutic strategies against white matter loss. Here, it was evaluated
-
Cyclic AMP signaling promotes regeneration of cochlear synapses after excitotoxic or noise trauma Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Sriram Hemachandran, Ning Hu, Catherine J. Kane, Steven H. Green
IntroductionCochlear afferent synapses connecting inner hair cells to spiral ganglion neurons are susceptible to excitotoxic trauma on exposure to loud sound, resulting in a noise-induced cochlear synaptopathy (NICS). Here we assessed the ability of cyclic AMP-dependent protein kinase (PKA) signaling to promote cochlear synapse regeneration, inferred from its ability to promote axon regeneration in
-
Retinoic acid modulation of granule cell activity and spatial discrimination in the adult hippocampus Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Yun-Gwon Yeo, Jeongrak Park, Yoonsub Kim, Jong-Cheol Rah, Chang-Hoon Shin, Seo-Jin Oh, Jin-Hyeok Jang, Yaebin Lee, Jong Hyuk Yoon, Yong-Seok Oh
Retinoic acid (RA), derived from vitamin A (retinol), plays a crucial role in modulating neuroplasticity within the adult brain. Perturbations in RA signaling have been associated with memory impairments, underscoring the necessity to elucidate RA’s influence on neuronal activity, particularly within the hippocampus. In this study, we investigated the cell type and sub-regional distribution of RA-responsive
-
Short-term hyperoxia-induced functional and morphological changes in rat hippocampus Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-15 Alexandra Julia Hencz, Andor Magony, Chloe Thomas, Krisztina Kovacs, Gabor Szilagyi, Jozsef Pal, Attila Sik
Excess oxygen (O2) levels may have a stimulating effect, but in the long term, and at high concentrations of O2, it is harmful to the nervous system. The hippocampus is very sensitive to pathophysiological changes and altered O2 concentrations can interfere with hippocampus-dependent learning and memory functions. In this study, we investigated the hyperoxia-induced changes in the rat hippocampus to
-
An overview of preclinical models of traumatic brain injury (TBI): relevance to pathophysiological mechanisms Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-12 Arman Fesharaki-Zadeh, Dibyadeep Datta
BackgroundTraumatic brain injury (TBI) is a major cause of morbidity and mortality, affecting millions annually worldwide. Although the majority of TBI patients return to premorbid baseline, a subset of patient can develop persistent and often debilitating neurocognitive and behavioral changes. The etiology of TBI within the clinical setting is inherently heterogenous, ranging from sport related injuries
-
Orexins in apoptosis: a dual regulatory role Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-12 Simona Cavalu, Sameh Saber, Rabab S. Hamad, Mustafa Ahmed Abdel-Reheim, Elsayed A. Elmorsy, Mahmoud E. Youssef
The orexins, also referred to as hypocretins, are neuropeptides that originate from the lateral hypothalamus (LH) region of the brain. They are composed of two small peptides, orexin-A, and orexin-B, which are broadly distributed throughout the central and peripheral nervous systems. Orexins are recognized to regulate diverse functions, involving energy homeostasis, the sleep-wake cycle, stress responses
-
GABAergic interneuron diversity and organization are crucial for the generation of human-specific functional neural networks in cerebral organoids Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-11 Sebastian H. Heesen, Georg Köhr
This mini review investigates the importance of GABAergic interneurons for the network function of human-induced pluripotent stem cells (hiPSC)-derived brain organoids. The presented evidence suggests that the abundance, diversity and three-dimensional cortical organization of GABAergic interneurons are the primary elements responsible for the creation of synchronous neuronal firing patterns. Without
-
Inhibiting presynaptic calcium channel motility in the auditory cortex suppresses synchronized input processing Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-10 Katrina E. Deane, Ruslan Klymentiev, Jennifer Heck, Melanie D. Mark, Frank W. Ohl, Martin Heine, Max F. K. Happel
IntroductionThe emergent coherent population activity from thousands of stochastic neurons in the brain is believed to constitute a key neuronal mechanism for salient processing of external stimuli and its link to internal states like attention and perception. In the sensory cortex, functional cell assemblies are formed by recurrent excitation and inhibitory influences. The stochastic dynamics of each
-
B cells and the stressed brain: emerging evidence of neuroimmune interactions in the context of psychosocial stress and major depression Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-08 Elizabeth Engler-Chiurazzi
The immune system has emerged as a key regulator of central nervous system (CNS) function in health and in disease. Importantly, improved understanding of immune contributions to mood disorders has provided novel opportunities for the treatment of debilitating stress-related mental health conditions such as major depressive disorder (MDD). Yet, the impact to, and involvement of, B lymphocytes in the
-
Impaired astrocytic synaptic function by peripheral cholesterol metabolite 27-hydroxycholesterol Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-08 Fokion Spanos, Gorka Gerenu, Julen Goikolea, María Latorre-Leal, Hugo Balleza-Tapia, Karen Gomez, Laura Álvarez-Jiménez, Antonio Piras, Marta Gómez-Galán, André Fisahn, Angel Cedazo-Minguez, Silvia Maioli, Raúl Loera-Valencia
Astrocytes represent the most abundant cell type in the brain, where they play critical roles in synaptic transmission, cognition, and behavior. Recent discoveries show astrocytes are involved in synaptic dysfunction during Alzheimer’s disease (AD). AD patients have imbalanced cholesterol metabolism, demonstrated by high levels of side-chain oxidized cholesterol known as 27-hydroxycholesterol (27-OH)
-
Micro-and mesoscale aspects of neurodegeneration in engineered human neural networks carrying the LRRK2 G2019S mutation Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-05
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been widely linked to Parkinson’s disease, where the G2019S variant has been shown to contribute uniquely to both familial and sporadic forms of the disease. LRRK2-related mutations have been extensively studied, yet the wide variety of cellular and network events related to these mutations remain poorly understood. The advancement and
-
Knockdown of tgfb1a partially improves ALS phenotype in a transient zebrafish model Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-05
Amyotrophic lateral sclerosis (ALS) corresponds to a neurodegenerative disorder marked by the progressive degeneration of both upper and lower motor neurons located in the brain, brainstem, and spinal cord. ALS can be broadly categorized into two main types: sporadic ALS (sALS), which constitutes approximately 90% of all cases, and familial ALS (fALS), which represents the remaining 10% of cases. Transforming
-
Knockdown of tgfb1a partially improves ALS phenotype in a transient zebrafish model Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-05 David Gonzalez, Xiomara Cuenca, Miguel L. Allende
Amyotrophic lateral sclerosis (ALS) corresponds to a neurodegenerative disorder marked by the progressive degeneration of both upper and lower motor neurons located in the brain, brainstem, and spinal cord. ALS can be broadly categorized into two main types: sporadic ALS (sALS), which constitutes approximately 90% of all cases, and familial ALS (fALS), which represents the remaining 10% of cases. Transforming
-
Micro-and mesoscale aspects of neurodegeneration in engineered human neural networks carrying the LRRK2 G2019S mutation Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-05 Vibeke Devold Valderhaug, Ola Huse Ramstad, Rosanne van de Wijdeven, Kristine Heiney, Stefano Nichele, Axel Sandvig, Ioanna Sandvig
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been widely linked to Parkinson’s disease, where the G2019S variant has been shown to contribute uniquely to both familial and sporadic forms of the disease. LRRK2-related mutations have been extensively studied, yet the wide variety of cellular and network events related to these mutations remain poorly understood. The advancement and
-
5-HT4 receptor agonists treatment reduces tau pathology and behavioral deficit in the PS19 mouse model of tauopathy Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-04
BackgroundAccumulation of tau in synapses in the early stages of Alzheimer’s disease (AD) has been shown to cause synaptic damage, synaptic loss, and the spread of tau pathology through trans-synaptically connected neurons. Moreover, synaptic loss correlates with a decline in cognitive function, providing an opportunity to investigate therapeutic strategies to target synapses and synaptic tau to rescue
-
Abnormal cell sorting and altered early neurogenesis in a human cortical organoid model of Protocadherin-19 clustering epilepsy Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-04
IntroductionProtocadherin-19 (PCDH19)-Clustering Epilepsy (PCE) is a developmental and epileptic encephalopathy caused by loss-of-function variants of the PCDH19 gene on the X-chromosome. PCE affects females and mosaic males while male carriers are largely spared. Mosaic expression of the cell adhesion molecule PCDH19 due to random X-chromosome inactivation is thought to impair cell–cell interactions
-
Cognitive impairment, neuroimaging abnormalities, and their correlations in myotonic dystrophy: a comprehensive review Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-04
Myotonic dystrophy (DM) encompasses a spectrum of neuromuscular diseases characterized by myotonia, muscle weakness, and wasting. Recent research has led to the recognition of DM as a neurological disorder. Cognitive impairment is a central nervous system condition that has been observed in various forms of DM. Neuroimaging studies have increasingly linked DM to alterations in white matter (WM) integrity
-
The case for neuregulin-1 as a clinical treatment for stroke Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-04
Ischemic stroke is the leading cause of serious long-term disability and the 5th leading cause of death in the United States. Revascularization of the occluded cerebral artery, either by thrombolysis or endovascular thrombectomy, is the only effective, clinically-approved stroke therapy. Several potentially neuroprotective agents, including glutamate antagonists, anti-inflammatory compounds and free
-
Case report: Marked electroclinical improvement by fluoxetine treatment in a patient with KCNT1-related drug-resistant focal epilepsy Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-04
Variants in KCNT1 are associated with a wide spectrum of epileptic phenotypes, including epilepsy of infancy with migrating focal seizures (EIMFS), non-EIMFS developmental and epileptic encephalopathies, autosomal dominant or sporadic sleep-related hypermotor epilepsy, and focal epilepsy. Here, we describe a girl affected by drug-resistant focal seizures, developmental delay and behavior disorders
-
Abnormal cell sorting and altered early neurogenesis in a human cortical organoid model of Protocadherin-19 clustering epilepsy Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-04 Wei Niu, Lu Deng, Sandra P. Mojica-Perez, Andrew M. Tidball, Roksolana Sudyk, Kyle Stokes, Jack M. Parent
IntroductionProtocadherin-19 (PCDH19)-Clustering Epilepsy (PCE) is a developmental and epileptic encephalopathy caused by loss-of-function variants of the PCDH19 gene on the X-chromosome. PCE affects females and mosaic males while male carriers are largely spared. Mosaic expression of the cell adhesion molecule PCDH19 due to random X-chromosome inactivation is thought to impair cell–cell interactions
-
Cognitive impairment, neuroimaging abnormalities, and their correlations in myotonic dystrophy: a comprehensive review Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-04 Yanyun Wu, Qianqian Wei, Junyu Lin, Huifang Shang, Ruwei Ou
Myotonic dystrophy (DM) encompasses a spectrum of neuromuscular diseases characterized by myotonia, muscle weakness, and wasting. Recent research has led to the recognition of DM as a neurological disorder. Cognitive impairment is a central nervous system condition that has been observed in various forms of DM. Neuroimaging studies have increasingly linked DM to alterations in white matter (WM) integrity
-
Case report: Marked electroclinical improvement by fluoxetine treatment in a patient with KCNT1-related drug-resistant focal epilepsy Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-04 Ilaria Mosca, Elena Freri, Paolo Ambrosino, Giorgio Belperio, Tiziana Granata, Laura Canafoglia, Francesca Ragona, Roberta Solazzi, Ilaria Filareto, Barbara Castellotti, Giuliana Messina, Cinzia Gellera, Jacopo C. DiFrancesco, Maria Virginia Soldovieri, Maurizio Taglialatela
Variants in KCNT1 are associated with a wide spectrum of epileptic phenotypes, including epilepsy of infancy with migrating focal seizures (EIMFS), non-EIMFS developmental and epileptic encephalopathies, autosomal dominant or sporadic sleep-related hypermotor epilepsy, and focal epilepsy. Here, we describe a girl affected by drug-resistant focal seizures, developmental delay and behavior disorders
-
5-HT4 receptor agonists treatment reduces tau pathology and behavioral deficit in the PS19 mouse model of tauopathy Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-04 Shan Jiang, Eric J. Sydney, Avery M. Runyan, Rossana Serpe, Malavika Srikanth, Helen Y. Figueroa, Mu Yang, Natura Myeku
BackgroundAccumulation of tau in synapses in the early stages of Alzheimer’s disease (AD) has been shown to cause synaptic damage, synaptic loss, and the spread of tau pathology through trans-synaptically connected neurons. Moreover, synaptic loss correlates with a decline in cognitive function, providing an opportunity to investigate therapeutic strategies to target synapses and synaptic tau to rescue
-
The case for neuregulin-1 as a clinical treatment for stroke Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-04 Jessica M. Noll, Arya A. Sherafat, Gregory D. Ford, Byron D. Ford
Ischemic stroke is the leading cause of serious long-term disability and the 5th leading cause of death in the United States. Revascularization of the occluded cerebral artery, either by thrombolysis or endovascular thrombectomy, is the only effective, clinically-approved stroke therapy. Several potentially neuroprotective agents, including glutamate antagonists, anti-inflammatory compounds and free
-
Vasoactive intestinal peptide excites GnRH neurons via KCa3.1, a potential player in the slow afterhyperpolarization current Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-03
Vasoactive intestinal peptide (VIP) is an important component of the suprachiasmatic nucleus (SCN) which relays circadian information to neuronal populations, including GnRH neurons. Human and animal studies have shown an impact of disrupted daily rhythms (chronic shift work, temporal food restriction, clock gene disruption) on both male and female reproduction and fertility. To date, how VIP modulates
-
Axon morphology and intrinsic cellular properties determine repetitive transcranial magnetic stimulation threshold for plasticity Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-03
IntroductionRepetitive transcranial magnetic stimulation (rTMS) is a widely used therapeutic tool in neurology and psychiatry, but its cellular and molecular mechanisms are not fully understood. Standardizing stimulus parameters, specifically electric field strength, is crucial in experimental and clinical settings. It enables meaningful comparisons across studies and facilitates the translation of
-
Vasoactive intestinal peptide excites GnRH neurons via KCa3.1, a potential player in the slow afterhyperpolarization current Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-03 Stephanie Constantin, Clarisse Quignon, Katherine Pizano, David M. Shostak, Susan Wray
Vasoactive intestinal peptide (VIP) is an important component of the suprachiasmatic nucleus (SCN) which relays circadian information to neuronal populations, including GnRH neurons. Human and animal studies have shown an impact of disrupted daily rhythms (chronic shift work, temporal food restriction, clock gene disruption) on both male and female reproduction and fertility. To date, how VIP modulates
-
Axon morphology and intrinsic cellular properties determine repetitive transcranial magnetic stimulation threshold for plasticity Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-03 Christos Galanis, Lena Neuhaus, Nicholas Hananeia, Zsolt Turi, Peter Jedlicka, Andreas Vlachos
IntroductionRepetitive transcranial magnetic stimulation (rTMS) is a widely used therapeutic tool in neurology and psychiatry, but its cellular and molecular mechanisms are not fully understood. Standardizing stimulus parameters, specifically electric field strength, is crucial in experimental and clinical settings. It enables meaningful comparisons across studies and facilitates the translation of
-
Plexin B3 guides axons to cross the midline in vivo Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-02
During the development of neural circuits, axons are guided by a variety of molecular cues to navigate through the brain and establish precise connections with correct partners at the right time and place. Many axon guidance cues have been identified and they play pleiotropic roles in not only axon guidance but also axon fasciculation, axon pruning, and synaptogenesis as well as cell migration, angiogenesis
-
Plexin B3 guides axons to cross the midline in vivo Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-04-02 Zhi-Zhi Liu, Ling-Yan Liu, Lou-Yin Zhu, Jian Zhu, Jia-Yu Luo, Ye-Fan Wang, Hong A. Xu
During the development of neural circuits, axons are guided by a variety of molecular cues to navigate through the brain and establish precise connections with correct partners at the right time and place. Many axon guidance cues have been identified and they play pleiotropic roles in not only axon guidance but also axon fasciculation, axon pruning, and synaptogenesis as well as cell migration, angiogenesis
-
Repetitive pulsed-wave ultrasound stimulation suppresses neural activity by modulating ambient GABA levels via effects on astrocytes Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-29 Tatsuya Mishima, Kenta Komano, Marie Tabaru, Takefumi Kofuji, Ayako Saito, Yoshikazu Ugawa, Yasuo Terao
Ultrasound is highly biopermeable and can non-invasively penetrate deep into the brain. Stimulation with patterned low-intensity ultrasound can induce sustained inhibition of neural activity in humans and animals, with potential implications for research and therapeutics. Although mechanosensitive channels are involved, the cellular and molecular mechanisms underlying neuromodulation by ultrasound
-
Striatal insights: a cellular and molecular perspective on repetitive behaviors in pathology Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-27 Charlotte Lauren Burton, Alessandra Longaretti, Andjela Zlatanovic, Guilherme Monteiro Gomes, Raffaella Tonini
Animals often behave repetitively and predictably. These repetitive behaviors can have a component that is learned and ingrained as habits, which can be evolutionarily advantageous as they reduce cognitive load and the expenditure of attentional resources. Repetitive behaviors can also be conscious and deliberate, and may occur in the absence of habit formation, typically when they are a feature of
-
Modeling sporadic juvenile ALS in iPSC-derived motor neurons explores the pathogenesis of FUSR503fs mutation Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-26 Li Chen, Guojie Chen, Mengting Zhang, Xiaojie Zhang
IntroductionFused in sarcoma (FUS) mutations represent the most common genetic etiology of juvenile amyotrophic lateral sclerosis (JALS), for which effective treatments are lacking. In a prior report, we identified a novel FUS mutation, c.1509dupA: p. R503fs (FUSR503fs), in a sporadic JALS patient.MethodsThe physicochemical properties and structure of FUSR503fs protein were analyzed by software: Multi-electrode
-
Vesicular translocation of PARP-1 to cytoplasm causes ADP-ribosylation and disassembly of vimentin filaments during microglia activation induced by LPS Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-25 Ruiqi Chen, Lirui Xie, Yang Fan, Xiangmei Hua, Chang Y. Chung
ADP-ribosylation plays a significant role in various biological processes including genomic stability maintenance, transcriptional regulation, energy metabolism, and cell death. Using macrodomain pull-down assay with microglia lysates and MALDI-TOF-MS analysis, we identified vimentin as a major protein highly ADP-ribosylated by the poly(ADP-ribose) polymerases-1 (PARP-1) in response to LPS. ABT-888
-
Representational maps in the brain: concepts, approaches, and applications Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-22 Takahiro Noda, Dominik F. Aschauer, Anna R. Chambers, Johannes P.-H. Seiler, Simon Rumpel
Neural systems have evolved to process sensory stimuli in a way that allows for efficient and adaptive behavior in a complex environment. Recent technological advances enable us to investigate sensory processing in animal models by simultaneously recording the activity of large populations of neurons with single-cell resolution, yielding high-dimensional datasets. In this review, we discuss concepts
-
What can the common fruit fly teach us about stroke?: lessons learned from the hypoxic tolerant Drosophila melanogaster Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-22 Princy S. Quadros-Mennella, Kurt M. Lucin, Robin E. White
Stroke, resulting in hypoxia and glucose deprivation, is a leading cause of death and disability worldwide. Presently, there are no treatments that reduce neuronal damage and preserve function aside from tissue plasminogen activator administration and rehabilitation therapy. Interestingly, Drosophila melanogaster, the common fruit fly, demonstrates robust hypoxic tolerance, characterized by minimal
-
The effects of urolithin A on poly I:C-induced microglial activation Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-20 Yakum Benard Mingo, Lea Gabele, Niklas Lonnemann, Bert Brône, Martin Korte, Shirin Hosseini
Neuroinflammation can be triggered by various stimuli, including viral infections. Viruses can directly invade the brain and infect neuronal cells or indirectly trigger a “cytokine storm” in the periphery that eventually leads to microglial activation in the brain. While this initial activation of microglial cells is important for viral clearance, chronic activation leads to excessive inflammation
-
The association between plasma IgG N-glycosylation and neonatal hypoxic–ischemic encephalopathy: a case-control study Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-20 Liangao Wang, Xinxia Lu, Meng Wang, Xuezhen Zhao, Peirui Li, Haitao Zhang, Qingtang Meng, Yujing Zhang, Yingjie Wang, Wei Wang, Long Ji, Haifeng Hou, Dong Li
IntroductionHypoxic-ischemic encephalopathy (HIE) is one of severe neonatal brain injuries, resulting from inflammation and the immune response after perinatal hypoxia and ischemia. IgG N-glycosylation plays a crucial role in various inflammatory diseases through mediating the balance between anti-inflammatory and pro-inflammatory responses. This study aimed to explore the effect of IgG N-glycosylation
-
Nanoparticle-based optical interfaces for retinal neuromodulation: a review Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-20 Paul R. Stoddart, James M. Begeng, Wei Tong, Michael R. Ibbotson, Tatiana Kameneva
Degeneration of photoreceptors in the retina is a leading cause of blindness, but commonly leaves the retinal ganglion cells (RGCs) and/or bipolar cells extant. Consequently, these cells are an attractive target for the invasive electrical implants colloquially known as “bionic eyes.” However, after more than two decades of concerted effort, interfaces based on conventional electrical stimulation approaches
-
Inhibition of phospholipase D promotes neurological function recovery and reduces neuroinflammation after spinal cord injury in mice Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-20 Han Ke, Fan Bai, Zihan Li, Yanbing Zhu, Chunjia Zhang, Yan Li, Zuliyaer Talifu, Yunzhu Pan, Wubo Liu, Xin Xu, Feng Gao, Degang Yang, Liangjie Du, Yan Yu, Jianjun Li
IntroductionSpinal cord injury (SCI) is a severely disabling disease. Hyperactivation of neuroinflammation is one of the main pathophysiological features of secondary SCI, with phospholipid metabolism playing an important role in regulating inflammation. Phospholipase D (PLD), a critical lipid-signaling molecule, is known to be involved in various physiological processes, including the regulation of
-
Brain organoid protocols and limitations Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-20 Helen H. Zhao, Gabriel Haddad
Stem cell-derived organoid technology is a powerful tool that revolutionizes the field of biomedical research and extends the scope of our understanding of human biology and diseases. Brain organoids especially open an opportunity for human brain research and modeling many human neurological diseases, which have lagged due to the inaccessibility of human brain samples and lack of similarity with other
-
Platelet-activating factor receptor (PAFR) regulates neuronal maturation and synaptic transmission during postnatal retinal development Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-20 Barbara Dalmaso, Andre Mauricio Passos Liber, Dora Fix Ventura, Sonia Jancar, Carolina Beltrame Del Debbio
IntroductionPlatelet-activating factor (PAF), PAF receptor (PAFR), and PAF- synthesis/degradation systems are involved in essential CNS processes such as neuroblast proliferation, differentiation, migration, and synaptic modulation. The retina is an important central nervous system (CNS) tissue for visual information processing. During retinal development, the balance between Retinal Progenitor Cell
-
Engineered exosomes enriched with select microRNAs amplify their therapeutic efficacy for traumatic brain injury and stroke Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-19 Liang Chen, Ye Xiong, Michael Chopp, Yanlu Zhang
Traumatic brain injury (TBI) and stroke stand as prominent causes of global disability and mortality. Treatment strategies for stroke and TBI are shifting from targeting neuroprotection toward cell-based neurorestorative strategy, aiming to augment endogenous brain remodeling, which holds considerable promise for the treatment of TBI and stroke. Compelling evidence underscores that the therapeutic
-
The transcription factor Pou4f3 is essential for the survival of postnatal and adult mouse cochlear hair cells and normal hearing Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-19 Jarnail Singh, Michelle R. Randle, Bradley J. Walters, Brandon C. Cox
IntroductionHair cells (HCs) of the cochlea are responsible for sound transduction and hearing perception in mammals. Genetic mutations in the transcription factor Pou4f3 cause non-syndromic autosomal dominant hearing loss in humans (DFNA15) which varies in the age of onset depending on the individual mutation. Mouse models with germline deletion or mutations in Pou4f3 have previously demonstrated
-
The proteomic landscape of microglia in health and disease Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-15 Emma Davis, Amy F. Lloyd
Microglia are the resident immune cells of the central nervous system (CNS) and as such play crucial roles in regulating brain homeostasis. Their presence in neurodegenerative diseases is known, with neurodegeneration-associated risk genes heavily expressed in microglia, highlighting their importance in contributing to disease pathogenesis. Transcriptomics studies have uncovered the heterogeneous landscape
-
Emerging role of extracellular vesicles and exogenous stimuli in molecular mechanisms of peripheral nerve regeneration Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-15 Yara Izhiman, Leyla Esfandiari
Peripheral nerve injuries lead to significant morbidity and adversely affect quality of life. The peripheral nervous system harbors the unique trait of autonomous regeneration; however, achieving successful regeneration remains uncertain. Research continues to augment and expedite successful peripheral nerve recovery, offering promising strategies for promoting peripheral nerve regeneration (PNR).
-
Genetic tools for studying cochlear inhibition Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-15 Eleftheria Slika, Paul Albert Fuchs
Efferent feedback to the mammalian cochlea includes cholinergic medial olivocochlear neurons (MOCs) that release ACh to hyperpolarize and shunt the voltage change that drives electromotility of outer hair cells (OHCs). Via brainstem connectivity, MOCs are activated by sound in a frequency- and intensity-dependent manner, thereby reducing the amplification of cochlear vibration provided by OHC electromotility
-
Dynamics of parkinsonian oscillations mediated by transmission delays in a mean-field model of the basal ganglia Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-14 Atefeh Asadi, Mojtaba Madadi Asl, Alireza Valizadeh, Matjaž Perc
IntroductionNeural interactions in the brain are affected by transmission delays which may critically alter signal propagation across different brain regions in both normal and pathological conditions. The effect of interaction delays on the dynamics of the generic neural networks has been extensively studied by theoretical and computational models. However, the role of transmission delays in the development
-
Updates of the role of B-cells in ischemic stroke Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-14 Silin Wu, Sidra Tabassum, Cole T. Payne, Heng Hu, Aaron M. Gusdon, Huimahn A. Choi, Xuefang S. Ren
Ischemic stroke is a major disease causing death and disability in the elderly and is one of the major diseases that seriously threaten human health and cause a great economic burden. In the early stage of ischemic stroke, neuronal structure is destroyed, resulting in death or damage, and the release of a variety of damage-associated pattern molecules induces an increase in neuroglial activation, peripheral
-
Microglia at the blood brain barrier in health and disease Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-13 Meredith G. Mayer, Tracy Fischer
The blood brain barrier (BBB) plays a crucial role in maintaining brain homeostasis by selectively preventing the entry of substances from the peripheral blood into the central nervous system (CNS). Comprised of endothelial cells, pericytes, and astrocytes, this highly regulated barrier encompasses the majority of the brain’s vasculature. In addition to its protective function, the BBB also engages
-
Context is key: glucocorticoid receptor and corticosteroid therapeutics in outcomes after traumatic brain injury Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-11 Morgan A. Taylor, Olga N. Kokiko-Cochran
Traumatic brain injury (TBI) is a global health burden, and survivors suffer functional and psychiatric consequences that can persist long after injury. TBI induces a physiological stress response by activating the hypothalamic-pituitary-adrenal (HPA) axis, but the effects of injury on the stress response become more complex in the long term. Clinical and experimental evidence suggests long lasting
-
Glitches in the brain: the dangerous relationship between radiotherapy and brain fog Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-07 Noemi Marino, Martina Bedeschi, Melania Elettra Vaccari, Marco Cambiaghi, Anna Tesei
Up to approximately 70% of cancer survivors report persistent deficits in memory, attention, speed of information processing, multi-tasking, and mental health functioning, a series of symptoms known as “brain fog.” The severity and duration of such effects can vary depending on age, cancer type, and treatment regimens. In particular, every year, hundreds of thousands of patients worldwide undergo radiotherapy
-
Research progress on ferroptosis in the pathogenesis and treatment of neurodegenerative diseases Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-07 Lijuan Wang, Xiansong Fang, Baodian Ling, Fangsheng Wang, Yu Xia, Wenjuan Zhang, Tianyu Zhong, Xiaoling Wang
Globally, millions of individuals are impacted by neurodegenerative disorders including Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD). Although a great deal of energy and financial resources have been invested in disease-related research, breakthroughs in therapeutic approaches remain elusive. The breakdown of cells usually happens
-
Cell-free fat extract promotes axon regeneration and retinal ganglion cells survival in traumatic optic neuropathy Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-06 Yiyu Sun, Di Chen, Tao Dai, Ziyou Yu, Hui Xie, Xiangsheng Wang, Wenjie Zhang
Injuries to axons within the central nervous system (CNS) pose a substantial clinical challenge due to their limited regenerative capacity. This study investigates the therapeutic potential of Cell-free fat extract (CEFFE) in CNS injury. CEFFE was injected intravitreally after the optic nerve was crushed. Two weeks post-injury, quantification of regenerated axons and survival rates of retinal ganglion
-
Microglia-neuron interactions in schizophrenia Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-06 Sophia-Marie Hartmann, Johanna Heider, Richard Wüst, Andreas J. Fallgatter, Hansjürgen Volkmer
Multiple lines of evidence implicate increased neuroinflammation mediated by glial cells to play a key role in neurodevelopmental disorders such as schizophrenia. Microglia, which are the primary innate immune cells of the brain, are crucial for the refinement of the synaptic circuitry during early brain development by synaptic pruning and the regulation of synaptic plasticity during adulthood. Schizophrenia
-
5-HT1F receptor agonism induces mitochondrial biogenesis and increases cellular function in brain microvascular endothelial cells Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-05 Natalie E. Scholpa, Epiphani C. Simmons, Austin D. Thompson, Seth S. Carroll, Rick G. Schnellmann
IntroductionVascular and mitochondrial dysfunction are well-established consequences of multiple central nervous system (CNS) disorders, including neurodegenerative diseases and traumatic injuries. We previously reported that 5-hydroxytryptamine 1F receptor (5-HT1FR) agonism induces mitochondrial biogenesis (MB) in multiple organ systems, including the CNS.MethodsLasmiditan is a selective 5-HT1FR agonist
-
Out of the core: the impact of focal ischemia in regions beyond the penumbra Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-05 Ludmila Koukalova, Martina Chmelova, Zuzana Amlerova, Lydia Vargova
The changes in the necrotic core and the penumbra following induction of focal ischemia have been the focus of attention for some time. However, evidence shows, that ischemic injury is not confined to the primarily affected structures and may influence the remote areas as well. Yet many studies fail to probe into the structures beyond the penumbra, and possibly do not even find any significant results
-
Visualizing the trans-synaptic arrangement of synaptic proteins by expansion microscopy Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-29 Stefan Sachs, Sebastian Reinhard, Janna Eilts, Markus Sauer, Christian Werner
High fidelity synaptic neurotransmission in the millisecond range is provided by a defined structural arrangement of synaptic proteins. At the presynapse multi-epitope scaffolding proteins are organized spatially at release sites to guarantee optimal binding of neurotransmitters at receptor clusters. The organization of pre- and postsynaptic proteins in trans-synaptic nanocolumns would thus intuitively
-
MicroRNAs dysregulated in multiple sclerosis affect the differentiation of CG-4 cells, an oligodendrocyte progenitor cell line Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-29 Océane Perdaens, Pauline Bottemanne, Vincent van Pesch
IntroductionDemyelination is one of the hallmarks of multiple sclerosis (MS). While remyelination occurs during the disease, it is incomplete from the start and strongly decreases with its progression, mainly due to the harm to oligodendrocyte progenitor cells (OPCs), causing irreversible neurological deficits and contributing to neurodegeneration. Therapeutic strategies promoting remyelination are