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The efficacy of electroacupuncture for cervical nerve edema and movement disorder caused by the brachial plexus injury: a case report Front. Neurol. (IF 3.4) Pub Date : 2024-04-23 Chao Wang, Yingjun Liu, Lu Li, Haijuan Zhang, Ziyu Ye, Linfang Zhao
The brachial plexus injury (BPI) is one of the most severe types of peripheral nerve injuries, often caused by upper limb traction injury. In clinic, the surgery is widely used to treat the BPI. However, surgery may need to be performed multiple times at different stages, which carries risks and brings heavy economic burden. In non-surgical treatment, splinting, local injection of corticosteroids,
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Circulating plasma-derived extracellular vesicles expressing bone and kidney markers are associated with neurocognitive impairment in people living with HIV Front. Neurol. (IF 3.4) Pub Date : 2024-04-23 Erika G. Marques de Menezes, Scott A. Bowler, Cecilia M. Shikuma, Lishomwa C. Ndhlovu, Philip J. Norris
BackgroundAlthough effective antiretroviral therapy (ART) has improved the life expectancy of people with HIV (PWH), the prevalence of milder forms of HIV-associated neurocognitive disorders (HAND) persist, and it is associated with systemic and neuro-inflammatory processes that could impact other organ systems. However, the complex signaling mechanisms between the bone-kidney systems and the brain
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Case report: Cerebrospinal fluid neutrophilic pleocytosis upon intrathecal triamcinolone injection Front. Neurol. (IF 3.4) Pub Date : 2024-04-23 Thanos Tsaktanis, Jenny Stritzelberger, Vi Tuong Daniel To, Martin Uhl, Stefan Schwab, Dieter Heuss, Veit Rothhammer
Intrathecal corticosteroids, initially employed in the 1950s, faced declining use due to complications like arachnoiditis and aseptic meningitis. Triamcinolone, which is nowadays used as intrathecally applied glucocorticoid formulation, has been shown to beneficially influence spasticity without demonstrable influence on disease activity or progression. We here present the case of a patient with recurrent
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Whole-body muscle magnetic resonance imaging in inflammatory myopathy with mitochondrial pathology Front. Neurol. (IF 3.4) Pub Date : 2024-04-23 Wagner Cid Palmeira Cavalcante, André Macedo Serafim da Silva, Rodrigo de Holanda Mendonça, Cristiane de Araújo Martins Moreno, Bruna Moreira de Souza Proença, Júlio Brandão Guimarães, Alípio Gomes Ormond Filho, Edmar Zanoteli
IntroductionInflammatory myopathy with mitochondrial pathology (IM-Mito) is a rare condition described in a few case series, and it is not clear whether it is a specific disease or a variant of Inclusion Body Myositis (IBM). Radiological data of IM-Mito patients has only been evaluated in one study.AimTo analyze whole-body muscle magnetic resonance imaging (MRI) features in patients with IM-Mito compared
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Multimodal imaging of optic nerve head abnormalities in high myopia Front. Neurol. (IF 3.4) Pub Date : 2024-04-23 Ruihan Hu, Qiuyan Wu, Zuohuizi Yi, Changzheng Chen
Highly myopic optic nerve head (ONH) abnormalities encompass a series of complications resulting from the stretching of papillary and peripapillary structures during significant axial elongation. The morphological changes in the ONH typically initiate with disk tilting or rotation, progressing to PHOMS and PPA. Tissue defects in each layer manifest as focal lamina cribrosa defects (FLDs), peripapillary
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Efficacy of endovascular therapy for cerebral vasospasm following aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis Front. Neurol. (IF 3.4) Pub Date : 2024-04-23 Yu-Hu Ma, Rui Shang, Si-Hao Li, Ting Wang, Sen Lin, Chang-Wei Zhang
BackgroundCerebral vasospasm (CV) is a common complication of aneurysmal subarachnoid hemorrhage (aSAH), leading to increased morbidity and mortality rates. Endovascular therapy, particularly intra-arterial vasodilator infusion (IAVI), has emerged as a potential alternative treatment for CV.MethodsA systematic review and meta-analysis were conducted to compare the efficacy of endovascular therapy with
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Association between the systemic immuno-inflammation index and hearing loss: result from NHANES 2009–2018 Front. Neurol. (IF 3.4) Pub Date : 2024-04-23 Tingfeng Zhou, Jiesheng Mao, Pei Zhu, Xinru Yu, Xiaokai Yang
BackgroundA novel inflammatory marker that measures the degree of systemic immunoinflammation, the systemic immuno-inflammation index (SII) is frequently used to forecast a number of illnesses. According to earlier studies, inflammation may play a role in the pathophysiology of hearing loss (HL).MethodsA sample from the National Health and Nutrition Examination Survey (NHANES) covering the years 2009
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Benzyl isothiocyanate ameliorates cognitive function in mice of chronic temporal lobe epilepsy Front. Neurol. (IF 3.4) Pub Date : 2024-04-23 Chang Xiaoyu, Zhou Hongzhen, Peng Nan, Gao Tengwei, Gong Yanan, Guo Yan, La Haiyan, Ma Li, Wu Haiya, Wen Yujun, Zhang Rui
ObjectiveTemporal lobe epilepsy (TLE) is a prevalent refractory partial epilepsy seen in clinical practice, with most cases originating from the hippocampus and being characterized by impaired learning and memory. Oxidative stress plays a direct role in the development of epilepsy and neurodegeneration while promoting cognitive dysfunction. Previous research indicates that benzyl isothiocyanate (BITC)
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Practical use of DAT SPECT imaging in diagnosing dementia with Lewy bodies: a US perspective of current guidelines and future directions Front. Neurol. (IF 3.4) Pub Date : 2024-04-22 Deirdre M. O’Shea, Alexander Arkhipenko, Douglas Galasko, Jennifer G. Goldman, Zulfiqar Haider Sheikh, George Petrides, Jon B. Toledo, James E. Galvin
BackgroundDiagnosing Dementia with Lewy Bodies (DLB) remains a challenge in clinical practice. The use of 123I-ioflupane (DaTscan™) SPECT imaging, which detects reduced dopamine transporter (DAT) uptake—a key biomarker in DLB diagnosis—could improve diagnostic accuracy. However, DAT imaging is underutilized despite its potential, contributing to delays and suboptimal patient management.MethodsThis
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Global study of anti-NMDA encephalitis: a bibliometric analysis from 2005 to 2023 Front. Neurol. (IF 3.4) Pub Date : 2024-04-22 Xinyue Song, Zixin Luo, Duoqin Huang, Jialian Lv, Li Xiao, Ting Liang, Kang Zou
BackgroundAutoimmune diseases have always been one of the difficult diseases of clinical concern. Because of the diversity and complexity of its causative factors, unclear occurrence and development process and difficult treatment, it has become a key disease for researchers to study. And the disease explored in this paper, anti-NMDA encephalitis, belongs to a common type of autoimmune encephalitis
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Synthetic minority over-sampling technique-enhanced machine learning models for predicting recurrence of postoperative chronic subdural hematoma Front. Neurol. (IF 3.4) Pub Date : 2024-04-22 Zhihui Ni, Yehao Zhu, Yiwei Qian, Xinbo Li, Zhenqiu Xing, Yinan Zhou, Yu Chen, Lijie Huang, Jianjing Yang, Qichuan Zhuge
ObjectiveChronic subdural hematoma (CSDH) is a neurological condition with high recurrence rates, primarily observed in the elderly population. Although several risk factors have been identified, predicting CSDH recurrence remains a challenge. Given the potential of machine learning (ML) to extract meaningful insights from complex data sets, our study aims to develop and validate ML models capable
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Critical review of the evidence for Vojta Therapy: a systematic review and meta-analysis Front. Neurol. (IF 3.4) Pub Date : 2024-04-22 Juan Luis Sánchez-González, Ismael Sanz-Esteban, Mónica Menéndez-Pardiñas, Víctor Navarro-López, José Manuel Sanz-Mengíbar
IntroductionIt is essential to link the theoretical framework of any neurophysiotherapy approach with a detailed analysis of the central motor control mechanisms that influence motor behavior. Vojta therapy (VT) falls within interventions aiming to modify neuronal activity. Although it is often mistakenly perceived as exclusively pediatric, its utility spans various functional disorders by acting on
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Functional impact of bilateral vestibular loss and the unexplained complaint of oscillopsia Front. Neurol. (IF 3.4) Pub Date : 2024-04-22 Dario Geisinger, Zohar Elyoseph, Roy Zaltzman, Matti Mintz, Carlos R. Gordon
IntroductionThe vestibulo-ocular reflex (VOR) stabilizes vision during head movements. VOR disorders lead to symptoms such as imbalance, dizziness, and oscillopsia. Despite similar VOR dysfunction, patients display diverse complaints. This study analyses saccades, balance, and spatial orientation in chronic peripheral and central VOR disorders, specifically examining the impact of oscillopsia.MethodsParticipants
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Examining the utility of near infrared light as pre-exposure therapy to mitigate temporary noise-induced hearing loss in humans Front. Neurol. (IF 3.4) Pub Date : 2024-04-22 Erin Williams, Kayla Minesinger, Hilary Gallagher, J. R. Stefanson, Nathaniel Bridges, Natalie Jackson, Valerie Stark, Jennifer Coto, Suhrud Rajguru, Kurt Yankaskas, Rick Rogers, Michael E. Hoffer
IntroductionThis study sought to determine the effect of Occupational Safety and Health Administration (OSHA) compliant noise on auditory health and assess whether pre-noise near infrared (NIR) light therapy can mitigate the effects of noise exposure.MethodsOver four visits, participants (n = 30, NCT#: 03834714) with normal hearing completed baseline hearing health assessments followed by exposure
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First clinical implementation of insertion force measurement in cochlear implantation surgery Front. Neurol. (IF 3.4) Pub Date : 2024-04-22 Thomas S. Rau, Georg Böttcher-Rebmann, Viktor Schell, Jakob Cramer, Eralp Artukarslan, Claas Baier, Thomas Lenarz, Rolf Salcher
PurposeThe significance of atraumatic electrode array (EA) insertion in cochlear implant (CI) surgery is widely acknowledged, with consensus that forces due to EA insertion are directly correlated with insertion trauma. Unfortunately, the manual perception of these forces through haptic feedback is inherently limited, and techniques for in vivo force measurements to monitor the insertion are not yet
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Serial ASPECTS to predict stroke-associated pneumonia after thrombolysis in patients with acute ischemic stroke Front. Neurol. (IF 3.4) Pub Date : 2024-04-22 Sarawut Krongsut, Atiwat Soontornpun, Niyada Anusasnee
BackgroundStroke-associated pneumonia (SAP) is a serious complication in stroke patients, significantly increasing mortality. The Alberta Stroke Program Early CT Score (ASPECTS) is a recognized predictor of acute ischemic stroke outcomes. We aimed to investigate the performance of serial ASPECTS assessments (baseline ASPECTS, 24-h ASPECTS, and change in ASPECTS) for predicting SAP in patients with
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Magnetic resonance-guided focused ultrasound thalamotomy for essential tremor patients with low skull density ratio: a case-matched analysis Front. Neurol. (IF 3.4) Pub Date : 2024-04-22 Patrick R. Ng, Sarah E. Blitz, Melissa M. J. Chua, G. Rees Cosgrove
IntroductionSkull density ratio (SDR) is the ratio between the mean Hounsfield units of marrow and cortical bone, impacting energy transmission through the skull. Low SDR has been used as an exclusion criterion in major trials of magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy for medication-refractory essential tremor (ET). However, some studies have suggested that patients with
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A study on the association between prefrontal functional connectivity and non-suicidal self-injury in adolescents with depression Front. Neurol. (IF 3.4) Pub Date : 2024-04-22 Yan Guo, Ruoxi Lu, Yiwen Ou, Yuxin Huang, Jianyu Li, Ying Cui, Danian Li, Yanting Zheng, Xinyu Liang, Shijun Qiu, Yujie Liu
ObjectiveAmong adolescents with depression, the occurrence of non-suicidal self-injury (NSSI) behavior is prevalent, constituting a high-risk factor for suicide. However, there has been limited research on the neuroimaging mechanisms underlying adolescent depression and NSSI behavior, and the potential association between the two remains unclear. Therefore, this study aims to investigate the alterations
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Efficacy of repetitive transcranial magnetic stimulation in post-stroke cognitive impairment: an overview of systematic reviews Front. Neurol. (IF 3.4) Pub Date : 2024-04-22 Linli Zhang, Shan Gao, Chengshuo Wang, Yuanyuan Li, Huateng Yuan, Longjun Cao, Chong Gao
ObjectiveThe reliability of clinical evidence depends on high-quality meta-analyses/ systematic reviews (MAs/SRs). However, there has been no assessment of the quality of MAs/SRs for repetitive transcranial magnetic stimulation (rTMS) in post-stroke cognitive impairment (PSCI), both nationally and internationally. This article seeks to use radar plotting to visually present the quality of MAs/SRs on
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Effectiveness of tranexamic acid on chronic subdural hematoma recurrence: a meta-analysis and systematic review Front. Neurol. (IF 3.4) Pub Date : 2024-04-22 Wani Pan, Jinyang Hu, Xin Huang, Erlang Jin, Longfei Yao, Jing Han, Tiantian Liu
ObjectivesOur objective was to compare the effectiveness of TXA in improving recurrence in patients with chronic subdural hematoma (CSDH).MethodsEligible randomized controlled trials (RCTs), prospective trials and retrospective cohort studies were searched in PubMed, Cochrane Library, Embase, and CNKI from database inception to December 2023. After the available studies following inclusion and exclusion
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Research progress on the inhibition of oxidative stress by teriparatide in spinal cord injury Front. Neurol. (IF 3.4) Pub Date : 2024-04-22 Gangtong Ai, Moliang Xiong, Liang Deng, Jihuan Zeng, Qiang Xiao
Spinal cord injury (SCI) is currently a highly disabling disease, which poses serious harm to patients and their families. Due to the fact that primary SCI is caused by direct external force, current research on SCI mainly focuses on the treatment and prevention of secondary SCI. Oxidative stress is one of the important pathogenic mechanisms of SCI, and intervention of oxidative stress may be a potential
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Impact of renal function variability on long-term prognosis in ischemic stroke patients with atrial fibrillation Front. Neurol. (IF 3.4) Pub Date : 2024-04-22 Xiao Wang, Chun-fung Sin, Kay-Cheong Teo, William C. Y. Leung, Yuen-Kwun Wong, Roxanna K. C. Liu, Joshua W. Fok, Bonaventure Y. Ip, Hon Hang Kwan, Tsz Ching Lee, Bun Sheng, Edwin Kin-Keung Yip, Desmond Y. H. Yap, Hao Luo, Kui-Kai Lau
BackgroundAlthough renal dysfunction is associated with adverse clinical outcomes in patients with atrial fibrillation (AF) following stroke, the impact of renal function variability is unclear.AimThis study aimed to assess the association between renal function variability and various adverse clinical outcomes in patients with transient ischemic attack (TIA)/ischemic stroke and atrial fibrillation
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A CT texture-based nomogram for predicting futile reperfusion in patients with intraparenchymal hyperdensity after endovascular thrombectomy for acute anterior circulation large vessel occlusion Front. Neurol. (IF 3.4) Pub Date : 2024-04-19 Meijuan Dong, Chun Chen, Wei Chen, Kun An
BackgroundPost-thrombectomy intraparenchymal hyperdensity (PTIH) in patients with acute anterior circulation large vessel occlusion is a common CT sign associated with a higher incidence of futile reperfusion (FR). We aimed to develop a nomogram to predict FR specifically in patients with PTIH.MethodsWe retrospectively collected information on patients with acute ischemic stroke who underwent endovascular
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Age-related differences in the characteristics of persistent postural-perceptual dizziness Front. Neurol. (IF 3.4) Pub Date : 2024-04-19 Akina Fukushima, Kayoko Kabaya, Toshiya Minakata, Sachiyo Katsumi, Shinichi Esaki, Shinichi Iwasaki
ObjectiveTo investigate differences in the clinical characteristics of patients with persistent postural-perceptual dizziness (PPPD) according to age.MethodsWe retrospectively reviewed 143 patients diagnosed with PPPD. Patients were classified into three groups by age: young group (19 to 44 years, n = 60), middle-age group (45 to 64 years, n = 56), old group (65 to 85 years, n = 27). Demographic data
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Practical tool to identify Spasticity-Plus Syndrome amongst patients with multiple sclerosis. Algorithm development based on a conjoint analysis Front. Neurol. (IF 3.4) Pub Date : 2024-04-19 Óscar Fernández Fernández, Lucienne Costa-Frossard, Maria Luisa Martínez Ginés, Paloma Montero Escribano, José María Prieto González, Lluís Ramió-Torrentà, Yolanda Aladro, Ana Alonso Torres, Elena Álvarez Rodríguez, Andrés Labiano-Fontcuberta, Lamberto Landete Pascual, Ambrosio Miralles Martínez, Ester Moral Torres, Pedro Oliva-Nacarino
IntroductionThe Spasticity-Plus Syndrome (SPS) in multiple sclerosis (MS) refers to a combination of spasticity and other signs/symptoms such as spasms, cramps, bladder dysfunction, tremor, sleep disorder, pain, and fatigue. The main purpose is to develop a user-friendly tool that could help neurologists to detect SPS in MS patients as soon as possible.MethodsA survey research based on a conjoint analysis
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Neutrophil extracellular trap biomarkers in aneurysmal subarachnoid hemorrhage: early decline of DNase 1 activity associated with delayed cerebral ischemia Front. Neurol. (IF 3.4) Pub Date : 2024-04-19 Philipp Hendrix, Jens Witsch, Valérie Spalart, Hauke Schneider, Joachim Oertel, Jürgen Geisel, Kimberly Martinod, Sina Hemmer
IntroductionHigh-mobility group box 1 (HMGB1) protein is a critical mediator of neutrophil extracellular trap (NET) formation (NETosis). Myeloperoxidase (MPO)-DNA complexes, a biomarker of NETs, and HMGB1 have been associated with delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH). Additional mechanistic NET-related biomarkers and their role in the neuroinflammatory cascade
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Clinical features of neuronal intranuclear inclusion disease with seizures: a systematic literature review Front. Neurol. (IF 3.4) Pub Date : 2024-04-19 Jinwei Zhang, Ling Ling, Lei Xiang, Wenxia Li, Pengnan Bao, Wei Yue
BackgroundInfant, junior, and adult patients with neuronal intranuclear inclusion disease (NIID) present with various types of seizures. We aimed to conduct a systematic literature review on the clinical characteristics of NIID with seizures to provide novel insight for early diagnosis and treatment and to improve prognosis of these patients.MethodsWe used keywords to screen articles related to NIID
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Real-world data of tenecteplase vs. alteplase in the treatment of acute ischemic stroke: a single-center analysis Front. Neurol. (IF 3.4) Pub Date : 2024-04-19 Yu Yao, Yuefei Wu, Xiaoqin Zhang, Chang Liu, Lingling Cai, Yisha Ying, Jianhong Yang
BackgroundThis retrospective observational cohort study aimed to evaluate whether tenecteplase’s use for acute ischemic stroke (AIS) has time management advantages and clinical benefits.Methods144 AIS patients treated with alteplase and 120 with tenecteplase were included. We compared baseline clinical characteristics, key reperfusion therapy time indices [onset-to-treatment time (OTT), door-to-needle
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A novel MAPT variant (E342K) as a cause of familial progressive supranuclear palsy Front. Neurol. (IF 3.4) Pub Date : 2024-04-19 Hang Li, Qijun Li, Qin Weng, Ruixue Cui, Tzu-Chen Yen, Yanfeng Li
BackgroundMAPT variants are a known cause of frontotemporal dementia and Parkinsonian syndrome, of which progressive supranuclear palsy syndrome (PSP) is a rare manifestation.ObjectiveTo report a novel MAPT variant in a PSP pedigree with autosomal dominant inheritance pattern, and to produce a literature review of PSP patients with MAPT variants.MethodsA comprehensive clinical, genetic, and molecular
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Endovascular thrombectomy is cost-saving in patients with acute ischemic stroke with large infarct Front. Neurol. (IF 3.4) Pub Date : 2024-04-18 Julian Schwarting, Matthias F. Froelich, Jan S. Kirschke, Dirk Mehrens, Jannis Bodden, Dominik Sepp, Jonas Reis, Konstantinos Dimitriadis, Jens Ricke, Claus Zimmer, Tobias Boeckh-Behrens, Wolfgang G. Kunz
ObjectiveEndovascular thrombectomy (EVT) is the standard of care for acute large vessel occlusion stroke. Recently, the ANGEL-ASPECT and SELECT 2 trials showed improved outcomes in patients with acute ischemic Stroke presenting with large infarcts. The cost-effectiveness of EVT for this subpopulation of stroke patients has only been calculated using data from the previously published RESCUE-Japan LIMIT
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Hypogammaglobulinemia and infections in patients with multiple sclerosis treated with anti-CD20 treatments: a systematic review and meta-analysis of 19,139 multiple sclerosis patients Front. Neurol. (IF 3.4) Pub Date : 2024-04-18 Anas Elgenidy, Nagham Nader Abdelhalim, Mohammed Al-mahdi Al-kurdi, Lobna A. Mohamed, Mohamed M. Ghoneim, Ahmed Wagdy Fathy, Hazem Khaled Hassaan, Ahmed Anan, Omar Alomari
BackgroundRecent years have seen the emergence of disease-modifying therapies in multiple sclerosis (MS), such as anti-cluster of differentiation 20 (anti-CD20) monoclonal antibodies, aiming to modulate the immune response and effectively manage MS. However, the relationship between anti-CD20 treatments and immunoglobulin G (IgG) levels, particularly the development of hypogammaglobulinemia and subsequent
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A Multimodal Exertional Test for concussion: a pilot study in healthy athletes Front. Neurol. (IF 3.4) Pub Date : 2024-04-18 Kyla L. Pyndiura, Alex P. Di Battista, Doug Richards, Nick Reed, David W. Lawrence, Michael G. Hutchison
IntroductionExertional tests have become a promising tool to assist clinicians in the management of concussions, however require expensive equipment, extensive spaces, and specialized clinician expertise. As such, we developed a test with minimal resource requirements encompassing key elements of sport and physical activity. The purpose of this study was to pilot test the Multimodal Exertional Test
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Effectiveness of the acute stroke care map program in reducing in-hospital delay for acute ischemic stroke in a Chinese urban area: an interrupted time series analysis Front. Neurol. (IF 3.4) Pub Date : 2024-04-18 Rui Wen, Miaoran Wang, Wei Bian, Haoyue Zhu, Ying Xiao, Jing Zeng, Qian He, Yu Wang, Xiaoqing Liu, Yangdi Shi, Zhe Hong, Bing Xu
BackgroundTimely intravenous thrombolysis (IVT) is crucial for improving outcomes in acute ischemic stroke (AIS) patients. This study evaluates the effectiveness of the Acute Stroke Care Map (ASCaM) initiative in Shenyang, aimed at reducing door-to-needle times (DNT) and thus improving the timeliness of care for AIS patients.MethodsAn retrospective cohort study was conducted from April 2019 to December
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Use of the Canadian CT head rule for patients on anticoagulant/anti-platelet therapy presenting with mild traumatic brain injury: prospective observational study Front. Neurol. (IF 3.4) Pub Date : 2024-04-18 Laura Uccella, Cristiana Riboni, Francesco Polinelli, Carola Biondi, Graziano Uccheddu, Roberta Petrino, Pietro Majno-Hurst
Background and importanceMild traumatic brain injury (mTBI) is a frequent presentation in Emergency Department (ED). There are standardised guidelines, the Canadian CT Head Rule (CCHR), for CT scan in mTBI that rule out patients on either anticoagulant or anti-platelet therapy. All patients with these therapies undergo a CT scan irrespectively of other consideration.ObjectiveTo determine whether standard
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Neurofilament light chain as a biomarker for acute hepatic porphyrias Front. Neurol. (IF 3.4) Pub Date : 2024-04-18 Paulo Sgobbi, Paulo de Lima Serrano, Bruno de Mattos Lombardi Badia, Igor Braga Farias, Hélvia Bertoldo de Oliveira, Alana Strucker Barbosa, Camila Alves Pereira, Vanessa de Freitas Moreira, Ícaro França Navarro Pinto, Acary Souza Bulle Oliveira, Wladimir Bocca Vieira de Rezende Pinto
BackgroundAcute hepatic porphyrias (AHP) represent a rare group of inherited metabolic disorders of heme biosynthesis pathway. This study aims to determine the diagnostic and prognostic value of serum neurofilament light chain (NfL) as potential biomarker for AHP.MethodsWe conducted a cross-sectional observational study to evaluate NfL levels in patients with AHP. They were divided in different groups:
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Case report: A case of anti-glycine receptor encephalomyelitis triggered by post-transplant or COVID-19 infection? Front. Neurol. (IF 3.4) Pub Date : 2024-04-18 Zhengxue Zhang, Xiang Zhang, Mingming Dai, Yingying Wu, Yong You
Even though long-term immunosuppressant drugs (ISD) are employed to inhibit immune system activity, enhancing graft functionality and patient survival in solid organ transplantation (SOT), these transplants often lead to immune complications, with post-transplant autoimmune diseases of the central nervous system (CNS) being uncommon. Here, we detail the case of a 66-year-old woman who underwent a renal
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A narrative review on cervical artery dissection-related cranial nerve palsies Front. Neurol. (IF 3.4) Pub Date : 2024-04-18 Benjamin Dejakum, Stefan Kiechl, Michael Knoflach, Lukas Mayer-Suess
IntroductionThis study aimed to emphasize the importance of cranial nerve (CN) palsies in spontaneous cervical artery dissection (sCeAD).MethodsA search term-based literature review was conducted on “cervical artery dissection” and “cranial nerve palsy.” English and German articles published until October 2023 were considered.ResultsCranial nerve (CN) palsy in sCeAD is evident in approximately 10%
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Case report: Headache as the sole neurological symptom in autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy Front. Neurol. (IF 3.4) Pub Date : 2024-04-18 Eslam Shosha, Colleen Connolly, Adrian Budhram
Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a recently emerging autoimmune disease of the central nervous system (CNS); GFAP astrocytopathy is characterized by optic neuritis and meningoencephalomyelitis. We report the case of a 55-year-old man, otherwise healthy, who presented with isolated headaches for three months, without other features of meningoencephalitis or myelitis
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A novel variant of PLA2G6 gene related early-onset parkinsonism: a case report and literature review Front. Neurol. (IF 3.4) Pub Date : 2024-04-18 Dapeng Cai, Haohao Wu, Baogang Huang, Weiwei Xiao, Kang Du
This study reported a case of early-onset parkinsonism associated with a novel variant of the PLA2G6 gene. The boy first started showing symptoms at the age of 11, with gait instability and frequent falls. As the disease progressed, his gait instability worsened, and he developed difficulties with swallowing and speaking, although there was no apparent decline in cognitive function. An MRI of the head
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Causal role of immune cell phenotypes in idiopathic sudden sensorineural hearing loss: a bi-directional Mendelian randomization study Front. Neurol. (IF 3.4) Pub Date : 2024-04-17 Wanqing Li, Qiang Zhou, Linsa Zhou, Longhe Cao, Chuansai Zhu, Zhijian Dai, Sen Lin
BackgroundA growing body of evidence suggests that immunological processes have a significant role in developing idiopathic sudden sensorineural hearing loss (SSHL). However, few studies have examined the association between immune cell phenotype and SSHL using Mendelian Randomization (MR).MethodsThe online genome-wide association studies (GWAS) database was used to compile data from GWAS covering
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Potential value of serum prealbumin and serum albumin in the identification of postoperative delirium in patients undergoing knee/hip replacement: an observational study and internal validation study Front. Neurol. (IF 3.4) Pub Date : 2024-04-17 Bin Wang, Yan Xin, Xinhui Tang, Fei Wang, Shuhui Hua, Yunchao Yang, Shanling Xu, Hongyan Gong, Rui Dong, Yanan Lin, Chuan Li, Xu Lin, Yanlin Bi
BackgroundPostoperative delirium (POD) is a common postoperative neurological complication that can lead to a variety of postoperative complications. At present, the pathogenesis of POD is unclear. This study aims to explore the relationship between serum prealbumin and serum albumin and POD and whether serum prealbumin and serum albumin influence POD through POD core pathology.ObjectiveWe enrolled
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Association between the blood urea nitrogen-to-creatinine ratio and 3-month outcomes in patients with acute ischemic stroke: a secondary analysis based on a prospective cohort study Front. Neurol. (IF 3.4) Pub Date : 2024-04-17 Hongjuan Liu, Yongjun Chen, Quan Zhou, Guixiang Guo, Bohong Hu, Fangchao Wan, Jun Wen
IntroductionThis study aimed to assess the correlation between the blood urea nitrogen (BUN)-to-creatinine (BUN/Cr) ratio and adverse outcomes (AOs) at 3 months in patients with acute ischemic stroke (AIS) in the Korean population.MethodsThis cohort study encompassed 1906 cases of AIS at a South Korean hospital from January 2010 to December 2016. To determine the linear correlation between the BUN/Cr
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A longitudinal study of the brain structure network changes in HIV patients with ANI: combined VBM with SCN Front. Neurol. (IF 3.4) Pub Date : 2024-04-17 Fan Xu, Juming Ma, Wei Wang, Hongjun Li
BackgroundDespite the widespread adoption of combination antiretroviral therapy (cART) in managing HIV, the virus’s impact on the brain structure of patients remains significant. This study aims to longitudinally explore the persistent effects of HIV on brain structure, focusing on changes in gray matter volume (GMV) and structural covariance network (SCN) among patients at the Asymptomatic Neurocognitive
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Antiseizure medication and SUDEP – a need for unifying methodology in research Front. Neurol. (IF 3.4) Pub Date : 2024-04-17 Dag Bruheim Aurlien, Erik Taubøll
The risk of sudden unexpected death in epilepsy (SUDEP) increases with the frequency of generalized tonic–clonic seizures. Carbamazepine (CBZ) and lamotrigine (LTG) have been suggested to increase the risk. However, the prevailing viewpoint is that the choice of antiseizure medication (ASM) does not influence the occurrence. We have explored the approach to addressing this question in relevant studies
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Research trend of MRI application for lumbar disc degeneration with low back pain: a bibliometric analysis Front. Neurol. (IF 3.4) Pub Date : 2024-04-17 Azzam Saeed, Haoyue Shao, Kamal Hezam, Chaoxu Liu, Qiya Zhang, Xiangyu Tang
BackgroundLow Back Pain (LBP) is a pervasive and complex musculoskeletal condition affecting over 80% of the global population. Lumbar Disc Degeneration (LDD) significantly contributes to LBP, and MRI is crucial for its diagnosis and understanding. This study aimes to provide a comprehensive bibliometric analysis of MRI research on LDD with LBP, shedding light on research patterns, collaborations,
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Contralateral approach using microscope and tubular retractor system for ipsilateral decompression of lumbar degenerative lateral recess stenosis associated with narrow spinal canal Front. Neurol. (IF 3.4) Pub Date : 2024-04-17 Longfei Shu, Qingchun Mu, Feihu Dai, Wei Zhao, Madiha Zahra Syeda, Yuhai Wang
ObjectiveTo summarize the clinical effect of a single-center retrospective analysis of the contralateral approach with a microscope and tubular retractor system for ipsilateral decompression in patients with lumbar lateral recess stenosis and a narrow spinal canal.MethodsA total of 25 patients who underwent ipsilateral decompression surgery via a contralateral approach with microscope and tubular retractor
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Triple semicircular canal occlusion with endolymphatic sac decompression for intractable Meniere’s disease Front. Neurol. (IF 3.4) Pub Date : 2024-04-17 Jiawang Tian, Gendi Yin, Qian Zhang, Shuqi Zhang, Xiangli Zeng, Yongqi Li
BackgroundMeniere’s disease (MD) is characterized by idiopathic endolymphatic hydrops (ELH). Frequent vertigo attacks is the most disabling symptom of MD.ObjectiveThis study evaluated the efficacy of triple semicircular canal occlusion combined with endolymphatic sac decompression in the treatment of frequent vertigo in patients with MD.MethodsEleven patients with complete medical records were included
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The prevalence and associated factors for primary headache disorders in adolescents in eastern Sudan: a community-based cross-sectional study Front. Neurol. (IF 3.4) Pub Date : 2024-04-17 Saeed M. Omar, Osman M. Osman, Abdullah Al-Nafeesah, Ashwaq AlEed, Jaber Alfaifi, Ishag Adam
BackgroundHeadache disorder is the second-highest cause of disability worldwide; however, data are scarce on headache among adolescents, especially in Africa. There has yet to be published data on headache among adolescents in Sudan, the third-largest country in Africa. This study aimed to assess the prevalence of primary headache disorders and associated factors among adolescents (10–19 years) in
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High lactic acid levels in the brain contribute to the generation of focal slowing on the electroencephalogram Front. Neurol. (IF 3.4) Pub Date : 2024-04-17 Dmitry Alexandrovich Chegodaev, Polina Alekseevna Pavlova
Focal slowing on the EEG is often associated with structural pathology of the brain. Despite the clinical significance of focal slowing, the actual electrochemical mechanisms underlying this EEG phenomenon are still poorly understood. This paper briefly reviews the role of lactate in the pathogenesis of brain disorders that are primarily related to focal EEG slowing. An attempt is made to trace the
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Advances in research and application of artificial intelligence and radiomic predictive models based on intracranial aneurysm images Front. Neurol. (IF 3.4) Pub Date : 2024-04-17 Zhongjian Wen, Yiren Wang, Yuxin Zhong, Yiheng Hu, Cheng Yang, Yan Peng, Xiang Zhan, Ping Zhou, Zhen Zeng
Intracranial aneurysm is a high-risk disease, with imaging playing a crucial role in their diagnosis and treatment. The rapid advancement of artificial intelligence in imaging technology holds promise for the development of AI-based radiomics predictive models. These models could potentially enable the automatic detection and diagnosis of intracranial aneurysms, assess their status, and predict outcomes
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Diagnosis and therapies for patients with cerebral palsy over the past 30 years: a bibliometric analysis Front. Neurol. (IF 3.4) Pub Date : 2024-04-17 Lili Jiang, Weifang Yang, Huai Chen, Huangcheng Song, Song Zhang
BackgroundCurrently, the incidence of cerebral palsy is high in newborns. However, the current methods for diagnosing and treating patients with cerebral palsy are complex and poorly targeted. Moreover, these studies lack the support of bibliometric analysis results.ObjectiveOur study focused on a bibliometric analysis of published papers on the diagnosis and treatment of patients with cerebral palsy
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Upper limb motor assessment for stroke with force, muscle activation and interhemispheric balance indices based on sEMG and fNIRS Front. Neurol. (IF 3.4) Pub Date : 2024-04-17 Sijia Ye, Liang Tao, Shuang Gong, Yehao Ma, Jiajia Wu, Wanyi Li, Jiliang Kang, Min Tang, Guokun Zuo, Changcheng Shi
IntroductionUpper limb rehabilitation assessment plays a pivotal role in the recovery process of stroke patients. The current clinical assessment tools often rely on subjective judgments of healthcare professionals. Some existing research studies have utilized physiological signals for quantitative assessments. However, most studies used single index to assess the motor functions of upper limb. The
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Baseline characteristics and outcome of stroke patients after endovascular therapy according to previous symptomatic vascular disease and sex Front. Neurol. (IF 3.4) Pub Date : 2024-04-17 Marieta Peycheva, Giovanna Padlina, Kotryna Genceviciute, Marina P. Krasteva, Anna Boronylo, Martina B. Goeldlin, Madlaine Müller, Elena S. Wenz, Mandy D. Müller, Helly Hammer, Philipp Bücke, Sandra Bigi, Barbara Goeggel Simonetti, Angelika Hoffmann, Roza M. Umarova, Sara Pilgram-Pastor, Jan Gralla, Pasquale Mordasini, Kateryna Antonenko, Mirjam R. Heldner
AimThe aim of this study was to investigate baseline characteristics and outcome of patients after endovascular therapy (EVT) for acute large vessel occlusion (LVO) in relation to their history of symptomatic vascular disease and sex.MethodsConsecutive EVT-eligible patients with LVO in the anterior circulation admitted to our stroke center between 04/2015 and 04/2020 were included in this observational
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Cardiac dysfunctions in children with drug-resistant epilepsy Front. Neurol. (IF 3.4) Pub Date : 2024-04-16 Watthana Sridech, Kamonchanok Intamul, Kwannapas Saengsin, Nattarujee Wiwattanadittakul, Rekwan Sittiwangkul, Kamornwan Katanyuwong, Suchaya Silvilairat, Chinnuwat Sanguansermsri
ObjectiveThere were reports of cardiac dysfunction that led to sudden unexpected death in epilepsy (SUDEP) in patients with epilepsy. Early detection of cardiac dysfunction can lead to early management to prevent sudden cardiac death in these patients. The objective of our study is to assess cardiac functions in children with drug-resistant epilepsy (DRE) compared with the normal population by using
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Case report: Transition from anti-CD20 therapy to inebilizumab for 14 cases of neuromyelitis optica spectrum disorder Front. Neurol. (IF 3.4) Pub Date : 2024-04-16 Benjamin Osborne, Gabriela Romanow, J. Michael Hemphill, Myassar Zarif, Tracy DeAngelis, Tyler Kaplan, Unsong Oh, Johnathan Pinkhasov, Kristina Patterson, Michael Levy
Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune disorder of the central nervous system characterized by recurrent, disabling attacks that affect the optic nerve, spinal cord, and brain/brainstem. While rituximab, targeting CD20-positive B-cells, is used as an off-label therapy for NMOSD, some patients continue to exhibit breakthrough attacks and/or adverse reactions. Inebilizumab
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Immunophenotyping in routine clinical practice for predicting treatment response and adverse events in patients with MS Front. Neurol. (IF 3.4) Pub Date : 2024-04-16 Tobias Zrzavy, Kerstin Rieder, Viktoria Wuketich, Renate Thalhammer, Helmuth Haslacher, Patrick Altmann, Barbara Kornek, Nik Krajnc, Tobias Monschein, Christiane Schmied, Karin Zebenholzer, Gudrun Zulehner, Thomas Berger, Paulus Rommer, Fritz Leutmezer, Gabriel Bsteh
BackgroundRecent studies proposed cellular immunoprofiling as a surrogate for predicting treatment response and/or stratifying the occurrence of adverse events (AEs) in persons with multiple sclerosis (pwMS). However, applicability in real-world circumstances is not sufficiently addressed.ObjectiveWe aimed to explore whether standard routine clinical leukocyte phenotyping before treatment initiation
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Traumatic brain injury and occupational risk of low-level blast exposure on adverse career outcomes: an examination of administrative and medical separations from Service (2005–2015) Front. Neurol. (IF 3.4) Pub Date : 2024-04-16 Jennifer N. Belding, James Bonkowski, Robyn Englert
IntroductionAlthough traumatic brain injury (TBI) has been linked with adverse long-term health, less research has examined whether TBI is linked with non-clinical outcomes including involuntary job loss. Symptoms associated with TBI may influence one’s ability to maintain gainful employment including employment in the U.S. military. That influence may impact military service members with exposure
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The role of kinases in peripheral nerve regeneration: mechanisms and implications Front. Neurol. (IF 3.4) Pub Date : 2024-04-16 Xu Zhang, Xuchu Duan, Xiaoyu Liu
Peripheral nerve injury disease is a prevalent traumatic condition in current medical practice. Despite the present treatment approaches, encompassing surgical sutures, autologous nerve or allograft nerve transplantation, tissue engineering techniques, and others, an effective clinical treatment method still needs to be discovered. Exploring novel treatment methods to improve peripheral nerve regeneration
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Clinical study on the efficacy of postural control combined with electroacupuncture in treating dysphagia after stroke Front. Neurol. (IF 3.4) Pub Date : 2024-04-16 Yanli Wu, Zhongwen Zhang, Qing Li, Xiu Yuan, Jiange Ren, Yulin Chen, He Zhu
ObjectiveTo evaluate the clinical effectiveness of combining postural control with electroacupuncture in the treatment of dysphagia following stroke, with the goal of establishing a solid clinical foundation for this therapeutic approach and investigating potential mechanisms to stimulate additional research and progress in post-stroke dysphagia management.Methods138 patients who met the diagnostic
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Effects of acupuncture for Bell’s palsy patients in the acute phase and its impact on facial nerve edema: a study protocol for a randomized, controlled trial Front. Neurol. (IF 3.4) Pub Date : 2024-04-16 Zhidan Wang, Jie Zhang, Zhen Zhang, Yue Liu, Shuang Ren, Hao Sun, Di Meng, Ruoshi Liu, Yang Zhang
BackgroundBell’s palsy is an acute peripheral facial neuropathy, which is one of the most common causes of facial palsy of lower motor neurons. Facial nerve swelling is commonly observed in Bell’s palsy. Acupuncture therapy has been widely used in the treatment of Bell’s palsy. However, whether acupuncture can be effectively used in the acute stage is still controversial. There are no clinical trials