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Brain Temperature, Choline, N-Acetyl-Aspartate, and Myo-Inositol Measured by MRS Can Only Be Considered Diagnostic Biomarkers if Their Criteria are Met [Letter] Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-04-22 Josef Finsterer
Letter for the article Peripheral and Central Nervous System Biomarkers of Inflammation in Functional Seizures: Assessment with Magnetic Resonance Spectroscopy
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Building and Validation of an Acute Event Prediction Model for Severe Mental Disorders Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-04-17 Ting Wang, Lin Wang, Yunliang Yao, Nan Liu, Aiqin Peng, Min Ling, Fei Ye, JiaoJiao Sun
Background: The global incidence of acute events in psychiatric patients is intensifying, and models to successfully predict acute events have attracted much attention. Objective: To explore the influence factors of acute incident severe mental disorders (SMDs) and the application of Rstudio statistical software, and build and verify a nomogram prediction model. Methods: SMDs were taken as research
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Effects of Subjective Social Status and Self-Esteem in the Association Between Childhood Abuse and Adulthood Anxiety Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-04-16 Misaki Endo, Miki Ono, Ayaka Deguchi, Yoshio Iwata, Yu Tamada, Jiro Masuya, Hajime Tanabe, Naoki Hashimoto, Takeshi Inoue, Mina Honyashiki
Background: Subjective social status influences anxiety, but at present, the mechanism is not fully understood. It has been reported that negative childhood experiences, such as abuse, can influence depressive symptoms through subjective social status and personality traits, such as self-esteem. A similar mechanism is presumed to underlie anxiety symptoms in adulthood. Therefore, we hypothesized that
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Two-Hour Nicotine Withdrawal Improves Inhibitory Control Dysfunction in Male Smokers: Evidence from a Smoking-Cued Go/No-Go Task ERP Study Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-04-15 Lu Hou, Jing Zhang, Jing Liu, Chang Chen, Xuezheng Gao, Limin Chen, Zhenhe Zhou, Hongliang Zhou
Purpose: Nicotine withdrawal is a multifaceted physiological and psychological process that can induce a spectrum of mood disturbances. Gaining a more nuanced understanding of how pure nicotine withdrawal influences cognitive control functions may provide valuable insights for the enhancement of smoking cessation programs. This study investigated changes in inhibitory control function in smokers after
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Efficacy of Personalized Postoperative Epilepsy Management in Patients with Glioblastoma Utilizing IDH1 Gene Assessment Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-04-12 Gao-Qiang Meng, Shu Chen, Han-Bin Ye, Bao-Jun Ma, Shuo Tao, Zi Ye
Objective: We explored the correlation between the presence of isocitrate dehydrogenase-1 (IDH1) mutations and the incidence of postoperative epilepsy in patients with glioblastoma, as well as assessed the efficacy of preemptive administration of antiepileptic medications in mitigating the occurrence of postoperative epilepsy. Methods: Fifty-three patients who received a postoperative pathological
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Screening of Depression Among Medical Outpatients Visiting the University Teaching Hospital of Kigali, Rwanda Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-04-08 Jean Pierre Gafaranga, Leopold Bitunguhari, Charles Mudenge, Felix Manirakiza, Brian Kelly, Paul Gatabazi
Background: Depression is a significant global public health concern, affecting individuals across different age groups and cultural backgrounds. However, screening for depression remains an essential but often neglected aspect of healthcare, particularly in outpatient settings. This study aimed to assess the prevalence of depression among outpatients visiting the internal medicine department of the
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Effects of Anti-Seizure Medication on Neuregulin-1 Gene and Protein in Patients with First-Episode Focal Epilepsy Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-04-08 Xin Zhao, Guijiang Huang, Zhenrong Xie, Yaxiong Mo, Hongxuan Zhu, Yajie Gao, Yanbing Han, Wei Tang
Introduction: Neuregulin-1 (NRG-1) appears to play a role in the pathogenesis of several neuropsychiatric disorders, including epilepsy. We conducted a study to investigate the effect of anti-seizure medication on NRG-1 mRNA and NRG-1 protein levels in patients with first-episode focal epilepsy. Methods: The levels of NRG-1 mRNA isoforms (type I, II, III, and IV) in peripheral blood mononuclear cells
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Neural Correlates of Cognitive Dysfunction in Conditional Reasoning in Schizophrenia: An Event-Related Potential Study [Corrigendum] Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-04-06 Chang Chen, Qian Mei, Qi Liu, Meichen Lu, Lu Hou, Xiaohong Liu, Xuezheng Gao, Limin Chen, Zhenhe Zhou, Hongliang Zhou
Corrigendum for the article Neural Correlates of Cognitive Dysfunction in Conditional Reasoning in Schizophrenia: An Event-related Potential Study
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The Lived Experiences of Individuals and Coping Strategies in the Context of Internet Gaming Disorder: A Qualitative Study Within Higher Education Setting in Uganda Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-04-06 Viola Nalwoga, Simon Kizito, Eustes Kigongo, Praise Atwine, Amir Kabunga
Background: Internet Gaming Disorder (IGD), recognized as a mental disorder in both the Diagnostic and Statistical Manual (DSM-5) and International Classification of Diseases (ICD-11), poses significant threats to physical, social, and mental well-being. This study aims to delve into the experiences of individuals grappling with IGD. Methods and Materials: The study employed an interpretive phenomenology
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Traumatic Brain Injury Outcomes After Recreational Cannabis Use Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-04-03 Jerzy P Szaflarski, Magdalena Szaflarski
Purpose: Basic science data indicate potential neuroprotective effects of cannabinoids in traumatic brain injury (TBI). We aimed to evaluate the effects of pre-TBI recreational cannabis use on TBI outcomes. Patients and Methods: We used i2b2 (a scalable informatics framework; www.i2b2.org) to identify all patients presenting with acute TBI between 1/1/2014 and 12/31/2016, then conducted a double-abstraction
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Exploring a Potential Interaction Between the Effect of Specific Maternal Smoking Patterns and Comorbid Antenatal Depression in Causing Postpartum Depression Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-04-03 Anthony J Kondracki, John R Attia, Matthew J Valente, Kimberly B Roth, Marshall Akin, Claire A McCarthy, Jennifer L Barkin
Purpose: To explore a potential interaction between the effect of specific maternal smoking patterns and the presence of antenatal depression, as independent exposures, in causing postpartum depression (PPD). Methods: This case–control study of participants with singleton term births (N = 51220) was based on data from the 2017– 2018 Pregnancy Risk Assessment Monitoring System. Multivariable log-binomial
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4-Hydroxysesamin, a Modified Natural Compound, Attenuates Neuronal Apoptosis After Ischemic Stroke via Inhibiting MAPK Pathway [Letter] Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-04-03 Agriani Dini Pasiana, Hasta Handayani Idrus
Letter for the article 4-Hydroxysesamin, a Modified Natural Compound, Attenuates Neuronal Apoptosis After Ischemic Stroke via Inhibiting MAPK Pathway
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Stroke Recurrence Rate and Risk Factors Among Stroke Survivors in Sub-Saharan Africa: A Systematic Review Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-04-03 Scovia Nalugo Mbalinda, Mark Kaddumukasa, Josephine Nambi Najjuma, Martin Kaddumukasa, Jane Nakibuuka, Christopher J Burant, Shirley Moore, Carol Blixen, Elly T Katabira, Martha Sajatovic
Purpose: Evidence supporting secondary stroke in sub-Saharan Africa is scarce. This study describes the incidence of stroke recurrence and associated risk factors in sub-Saharan Africa. Methods and Materials: Scientific databases were systematically searched from January 2000 to December 2022 for population-based observational studies, case-control or cohort studies of recurrent stroke involving adults
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Fear of Flying, Stress and Epileptic-Like Symptoms Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-04-02 Matthew K Laker, Petr Bob, Norbert Riethof, Jiri Raboch
Background: Intense fear of flying, called aviophobia, is a highly prevalent psychological phenomenon, afflicting (in some estimates) up to 40% of the population of industrialized countries and although aviophobia is a highly prevalent mental health problem, published studies about its epidemiology and treatment are rare. Methods: In this study, including 61 participants (28 males and 33 females; mean
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The Impact of SARS-CoV-2 Infection on the Length of Stay in the Neuro-ICU:A Prospective Multicenter Cohort Study in Eight Neuro-ICU, China Between February and April 2023 Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-30 Liang Tan, Feilong Wang, Yi Huang, Chuhua Fu, Haijun Zhang, Jianfei Feng, Yincai Xu, Xinzhen Ye, Rongrui Tang, Yinglian Chen, Liansheng Mou, Ronghao Li, Jingyu Chen, Jishu Xian
Purpose: The SARS-CoV-2 infection cases are increasing rapidly in neuro-intensive care units (neuro-ICUs) at the beginning of 2023 in China. We aimed to characterize the prevalence, risk factors, and prognosis of critically ill patients treated in neuro-ICUs. Materials and Methods: In the prospective, multicenter, observational registry study, critically ill patients with intracerebral hemorrhage (ICH)
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Efficacy of HP-3070, A Once-Daily Asenapine Transdermal System, in the Treatment of Adults with Schizophrenia: A PANSS Five-Factor Analysis Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-29 Leslie Citrome, Mariacristina Castelli, Masami Hasebe, Takaaki Terahara, Justin Faden, Marina Komaroff
Introduction: HP-3070, a once-daily asenapine transdermal system, is the first antipsychotic “patch” formulation FDA approved for adults with schizophrenia. Positive and Negative Syndrome Scale (PANSS) score items can be grouped into a five-factor structure to describe specific schizophrenia symptom domains. This post hoc analysis of data from a pivotal study evaluated HP-3070’s efficacy by examining
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A Prospective Cohort Study of Elevated Serum NLRP1 Levels to Prognosticate Neurological Outcome After Acute Intracerebral Hemorrhage at a Single Academic Institution Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-29 Wei Li, Jun Wang, Chao Tang, Xuan Lv, Suijun Zhu
Background: Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 1 (NLRP1) participates in neuroinflammation. This study aimed to identify serum NLRP as a potential prognostic biomarker of acute intracerebral hemorrhage (ICH). Methods: This prospective cohort study enrolled 145 patients with supratentorial ICH and 51 healthy controls. Serum NLRP1 levels were quantified
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Clinical Features and Prognostic Analysis of MuSK-Antibody-Positive Myasthenia Gravis versus Double-Seropositive Myasthenia Gravis: A Single-Center Study from Central South China Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-29 Ting He, Kangzhi Chen, Yi Li, Zhaohui Luo, Mengchuan Luo, Huan Yang
Purpose: To decipher the discrepancies between muscle-specific kinase antibody-positive myasthenia gravis (MuSK-MG) and double-seropositive myasthenia gravis (DSP-MG), and to determine prognostic factors for minimal manifestation status (MMS) achievement in MG patients with MuSK autoantibodies (MuSK-Ab). Patients and Methods: A total of 34 MG patients seropositive for MuSK-Ab were enrolled in this
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Relationship Between Insomnia and Continued Outpatient Treatment in Psychiatric Patients Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-27 Yukinori Kamata, Osamu Takashio, Ryotaro Sato, Hideaki Kawai, Hiroki Ishii, Keisuke Aoyagi, Akisa Tomita, Shigenobu Toda, Akira Iwanami
Purpose: Sleep plays an essential role in maintaining both physical and mental well-being. Many patients in psychiatric outpatient settings complain of insomnia. However, the causal relationship between insomnia and depressive symptoms in all mental illnesses remains unclear. Moreover, research on insomnia and the continuation of outpatient treatment is lacking. We hypothesize a high correlation between
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Neuropsychiatric Symptoms Predict Faster Cognitive Decline in Dementia Collaborative Care Than Antipsychotic Use Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-26 Yen-Jen Chen, Ming-Che Chang, Kai-Ming Jhang, Wen-Fu Wang, Yi-Cheng Liao
Background: To compare short-term cognitive outcomes among groups with and without neuropsychiatric symptoms (NPSs) or antipsychotic prescription and to determine which disease status or treatment modality is associated with relatively faster cognitive decline. Methods: We retrospectively analyzed a prospective cohort of patients diagnosed with dementia and mild cognitive impairment. All participants
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Psychometric evaluation and linking of the PHQ-9, QIDS-C, and VQIDS-C in a real-world population with major depressive disorder Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-26 Emily OC Palmer, Sheryl Ker, Miguel E Rentería, Thomas Carmody, A John Rush
Purpose: Major depressive disorder (MDD) is a leading cause of disability worldwide. An accurate assessment of depressive symptomology is crucial for clinical management and research. This study assessed the convergent validity, reliability, and total scale score interconversion across the 9-item Patient Health Questionnaire (PHQ-9) self-report, the 16-item Quick Inventory of Depressive Symptomatology-clinician
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Neuropsychiatric Symptoms of Moyamoya Disease: Considerations for the Clinician Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-22 Carlee I Oakley, Giuseppe Lanzino, James P Klaas
Abstract: Neurocognitive impairment in moyamoya disease is common, under recognized, and potentially devastating. The purpose of this paper is to provide an updated overview on this topic for the practicing clinician. We searched PubMed for keywords including cognitive impairment, neurocognitive dysfunction, and neuropsychological recovery in moyamoya disease. We summarized the literature to provide
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Wenyang-Tianjing-Jieyu Decoction Improves Depression Rats of Kidney Yang Deficiency Pattern by Regulating T Cell Homeostasis and Inflammation Level Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-22 Tian Zhang, Jiexin Wang, Yi Wang, Linxi He, Shangbin Lv, Yiran Wang, Weihong Li
Purpose: Chronic inflammation is one of the key mechanisms of depression. Wenyang-Tianjin-Jie Decoction (WTJD) is an effective antidepressant found in the course of diagnosis and treatment, but the mechanism of therapeutic effect is not clear. The study aimed to evaluate the efficacy of WTJD in the kidney yang deficiency (KYD) type of depression rats and reveal its mechanisms. Materials and Methods:
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Repetitive Transcranial Magnetic Stimulation for Working Memory Deficits in Schizophrenia: A Systematic Review of Randomized Controlled Trials Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-21 Li Li, Chaomeng Liu, Weigang Pan, Wen Wang, Wenqing Jin, Yanping Ren, Xin Ma
Abstract: Working memory (WM) deficits are a significant component of neurocognitive impairment in individuals with schizophrenia (SCZ). Two previous meta-analyses, conducted on randomized controlled trials (RCTs), examined the effectiveness of repetitive transcranial magnetic stimulation (rTMS) in addressing WM deficits in individuals diagnosed with SCZ. However, the conclusions drawn from these analyses
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Endovascular Thrombectomy for Acute Ischemic Stroke in Indonesia: Challenging and Strategic Planning Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-21 Beny Rilianto, Ricky Gusanto Kurniawan, Nurfadilah M Rajab, Bambang Tri Prasetyo
Abstract: High rates of morbidity and mortality indicate that stroke is a major health concern. Unfortunately, the management of ischemic stroke is hindered by several obstacles, particularly in developing countries such as Indonesia, where the burden of morbidity and mortality remains high. In this literature review, we intend to conduct a thorough investigation and analysis of the obstacles to stroke
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New Therapeutic Targets and Drugs for Schizophrenia Beyond Dopamine D2 Receptor Antagonists Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-20 Aineng Peng, Jianbo Chai, Haiyuan Wu, Bing Bai, Huihui Yang, Weizhi He, Yonghou Zhao
Abstract: Schizophrenia is a disease with a complex pathological mechanism that is influenced by multiple genes. The study of its pathogenesis is dominated by the dopamine hypothesis, as well as other hypotheses such as the 5-hydroxytryptamine hypothesis, glutamate hypothesis, immune-inflammatory hypothesis, gene expression abnormality hypothesis, and neurodevelopmental abnormality hypothesis. The
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The Impact of Psychological Burdens and Vaccine Worries on Confidence and Adherence to Governmental Policies Against COVID-19 Among Patients with Substance Use Disorder: A Cross-Sectional Study in Taiwan Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-12 Dian-Jeng Li, Joh-Jong Huang, Su-Ting Hsu, Hui-Ching Wu, Kuan-Ying Hsieh, Guei-Ging Lin, Pei-Jhen Wu, Chin-Lien Liu, Frank Huang-Chih Chou
Introduction: The coronavirus disease 2019 (COVID-19) pandemic has had an impact on patients with substance use disorder (SUD). We aimed to investigate factors associated with confidence and adherence to governmental policies against COVID-19 (social desirability) among patients with SUD. Methods: This cross-sectional study was conducted during 2020 to 2021. Patients with SUD and healthy controls were
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Struggling Can Also Show on the Inside: Current Knowledge of the Impact of Childhood Maltreatment on Biomarkers in Mood Disorderss Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-12 Maj Vinberg, Roger S McIntyre, Annamaria Giraldi, Klara Coello
Abstract: The link between childhood maltreatment and mood disorders is complex and involves multiple bio-psycho-social factors that affect multiple molecular pathways. The present narrative review aims to clarify the current understanding of the impact of childhood maltreatment on biomarkers in patients with mood disorders and their first-degree relatives. Neurotransmitters, such as serotonin, dopamine
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Neural Correlates of Cognitive Dysfunction in Conditional Reasoning in Schizophrenia: An Event-related Potential Study Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-11 Chang Chen, Qian Mei, Qi Liu, Meichen Lu, Lu Hou, Xiaohong Liu, Xuezheng Gao, Limin Chen, Zhenhe Zhou, Hongliang Zhou
Purpose: Schizophrenia patients show impaired conditional reasoning. This study was to investigate event-related potential (ERP) characteristics of the conditional reasoning in schizophrenia. Patients and methods: Participants included 24 schizophrenia patients and 30 normal controls (NCs), and the measurements of ERPs were conducted during the Wason selection task. Results: Results showed that NCs
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Social Stigma Toward Individuals with Schizophrenia in a Lebanese Population Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-08 Sana Ahmad Tantawi, Atifa Nazih Kamaleddine, Lama Ali Alhajj, Sondos Mohamad Naous, Nafez Nazih Kamaleddine, Seockhoon Chung, Sung Woo Joo
Background: Schizophrenia has been recognized as the most stigmatized mental disorder, imposing a substantial burden on affected individuals. However, no prior studies have investigated social stigma toward individuals with schizophrenia in Lebanon. Purpose: We aimed to examine three components of social stigma including knowledge, attitude, and behavior toward individuals with schizophrenia in a Lebanese
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The Impact of Integrating a Low-Lectin Diet with Traditional ADHD Treatments on Gut Microbiota Composition and Symptom Improvement in Children - A Cohort Study Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-09 Liying Long, Haiyan Peng, Xi Chen, Fei Wang, Wenjie Long, Ming Cheng, Jing Ma
Background and Purpose: This study aimed to investigate the impact of implementing a low-lectin diet on gut microbiota composition and symptom amelioration in pediatric patients diagnosed with Attention Deficit Hyperactivity Disorder (ADHD). Methods: A total of 58 children (ages 7– 15 years), meeting the criteria for ADHD were recruited. In addition to standard medication treatment, participants in
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Effect of Surgical Masks and N95 Respirators on Anxiety Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-08 Yan Zhang, Qiongyao Yang, Qianru Ma, Yuanxiong Wu, Yue Wang, Chuanchuan Chen, Yitan Yao, Ziqiao Feng, Xiaoping Yuan, Shengya Shi, Kai Zhang
Purpose: Masks are designed to reduce the spread of airborne pathogens, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), although wearing a mask has some adverse effects. The primary objective of this study was to explore the effects of surgical masks and N95 respirators on patients diagnosed with anxiety. Methods: Subjects diagnosed with first-episode anxiety disorders were recruited
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4-Hydroxysesamin, a Modified Natural Compound, Attenuates Neuronal Apoptosis After Ischemic Stroke via Inhibiting MAPK Pathway Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-07 Lina Wang, Zhenzhen Qu, Qian Sun, Zhuofeng Mao, Peipei Si, Weiping Wang
Background: The 4-hydroxysesamin (4-HS, a di-tetrahydrofuran lignin) is a modified sesamin that was prepared in the laboratory. This preclinical study was designed to preliminarily investigate the neuroprotective properties of 4-HS. Methods: In vitro, neuronal injury and inflammation were simulated by oxygen-glucose deprivation and lipopolysaccharide (LPS) exposure in mouse hippocampal neuronal HT22
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Clinical Characteristics of Asymptomatic Thromboembolism in Psychiatric Inpatients: A Retrospective Study Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-07 Yimeng Geng, Peifen Zhang, Yanmeng Pan, Huaizhi Wang, Yi Chen, Jianbo Lai, Shaohua Hu
Purpose: Venous thromboembolism (VTE) poses a significant threat to individuals’ health, yet its correlation with mental disorders remains underappreciated. Here, we conducted a retrospective analysis to explore the characteristics of psychiatric patients presenting with VTE. Methods: We retrospectively analyzed psychiatric inpatients with elevated plasma D-dimer levels at the Mental Health Center
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Improving Diagnostic Procedures in Autism for Girls and Women: A Narrative Review Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-07 Julia Cook, Laura Hull, Will Mandy
Abstract: Biases exist in the diagnostic process for autism spectrum disorder (henceforth “autism”), which result in some girls and women being diagnosed later or missed entirely. Current diagnostic tools may not capture the full range of behavioural presentations of autism, leading to under-identification. This review explores why these biases may occur, and how diagnostic procedures could be adapted
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Synapse-Related Serum and P300 Biomarkers Predict the Occurrence of Mild Cognitive Impairment in Depression Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-05 Zongwei Xue, Xiaoyan Zhu, Wenqi Wu, Yan Zhu, Yuhao Xu, Ming Yu
Background: Cognitive impairment is one of the common concomitant symptoms of depression. The aims of the present study were to predict the occurrence of mild cognitive impairment (MCI) in patients with depression. Methods: In this study, 217 patients with depression were recruited. Demographic data, serum indices and ERP indices from all participants were collected in the baseline period. The participants
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Validation and Functional Relevance of the Short Form of the Perceived Deficits Questionnaire for Depression for Japanese Patients with Major Depressive Disorder [Corrigendum] Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-06 Tomiki Sumiyoshi, Hiroyuki Uchida, Koichiro Watanabe, Masato Oosawa, Hongye Ren, Yoshiya Moriguchi, Keita Fujikawa, Jovelle Fernandez
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Effects of Aripiprazole on Olanzapine Population Pharmacokinetics and Initial Dosage Optimization in Schizophrenia Patients Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-04 Cun Zhang, Lei Jiang, Ke Hu, Liang Chen, Yi-Jia Zhang, Hao-Zhe Shi, Su-Mei He, Xiao Chen, Dong-Dong Wang
Objective: Olanzapine has already been used to treat schizophrenia patients; however, the initial dosage recommendation when multiple drugs are used in combination, remains unclear. The purpose of this study was to explore the drug–drug interaction (DDI) of multiple drugs combined with olanzapine and to recommend the optimal administration of olanzapine in schizophrenia patients. Methods: In this study
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Severe Refractory Obsessive Compulsive Disorder and Depression: Should We Consider Stereotactic Neurosurgery? Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-04 Ludvic Zrinzo
Abstract: Functional neurosurgery involves modulation of activity within neural circuits that drive pathological activity. Neurologists and neurosurgeons have worked closely together, advancing the field for over a century, such that neurosurgical procedures for movement disorders are now accepted as “standard of care”, benefiting hundreds of thousands of patients. As with movement disorders, some
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Clinical Analysis of Lacosamide Monotherapy in the Treatment of Self-Limited Epilepsy with Centrotemporal Spikes Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-04 Jun Feng, Liya Zhang, Jihong Tang, Bingbing Zhang, Xiao Xiao, Xiaoyan Shi
Objective: To evaluate the efficacy and safety of lacosamide (LCM) monotherapy in the treatment of self-limited epilepsy with centrotemporal spikes (SeLECTS). Methods: In this study, 89 children with SeLECTS who were treated with LCM monotherapy in the Children’s Hospital Affiliated to Soochow University from June 2019 to June 2021 were included. Clinical seizures and spike wave index (SWI) on video
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Prognostic Significance of Uric Acid Levels in Intracerebral Hemorrhage Patients Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-01 Wenpei Wu, Zhi Geng, Aimei Wu, Xinyi Chen, Xiaoying Meng, Qianyun Zhang, Zheng Tan, Hong Yue, Juncang Wu
Background and Purpose: The role of serum uric acid (UA) level in patients suffering from stroke remains controversial. Our aim was to investigate the effect of UA level on clinical outcomes in patients with intracerebral hemorrhage (ICH). Methods: In the retrospective cohort study, we analyzed data from 250 patients with intracerebral hemorrhage (85 women and 165 men) to investigate the difference
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Investigating Factors Associated with the Development of Postnatal Depression After Cesarean Delivery: A Validation Cohort Study Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-29 Daryl Jian An Tan, Rehena Sultana, Sheryl Yu Xuan Chow, Chin Wen Tan, Hon Sen Tan, Helen Yu Chen, Tze-Ern Chua, Ban Leong Sng
Purpose: This study aimed to validate a proposed association model previously published to determine the clinical relevance of pre-operative determinants in the development of PND after Cesarean delivery (CD). Patients and Methods: Parturients undergoing elective CD under neuraxial anesthesia were recruited for a prospective cohort study between Oct 2021 and Oct 2022 at KK Women’s and Children’s Hospital
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Validity and Reliability Study of the Turkish Version of the Orbach Mikulincer Mental Pain Scale-8 in a Clinical Population Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-01 Mehmet Emin Demirkol, Lut Tamam, Zeynep Namlı, Caner Yeşiloğlu, Hamdi Yılmaz
Purpose: Suicide is a growing public health issue for all societies; identifying suicide risk is crucial. This study aims to evaluate the psychometric properties of the Turkish version of the Orbach and Mikulincer Mental Pain Scale-8 (OMMP-8), which enables the assessment of suicidality in a short time. Patients and Methods: We conducted this study with 148 individuals diagnosed with major depressive
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The Impact of Recent Life Events, Internalizing Symptoms, and Emotion Regulation on the Severity of Non-Suicidal Self-Injury in Adolescents: A Mediation Analysis Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-29 Linqi Zhou, Changyuan Qiao, Jialing Huang, Jian Lin, Haisheng Zhang, Jian Xie, Yonggui Yuan, Changchun Hu
Background: Previous studies have demonstrated a strong association between recent stressful life events and non-suicidal self-injury (NSSI) among adolescents. Internalizing symptoms and difficulty in emotion regulation (DER) may mediate this relationship. This study aimed to investigate the relationship between recent stressful life events and NSSI severity in adolescents and the potential moderating
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Gut Microbiota Dysbiosis and Inflammation Dysfunction in Late-Life Depression: An Observational Cross-Sectional Analysis Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-27 Yan Chen, Dansheng Le, Jiaxi Xu, Piaopiao Jin, Yuhan Zhang, Zhengluan Liao
Purpose: There are some challenges to diagnosis in the context of similar diagnostic criteria for late-life depression (LLD) and adult depression due to cognitive impairment and other clinical manifestations. The association between gut microbiota and inflammation remains unclear in LLD. We analyzed gut microbiota characteristics and serum inflammatory cytokines in individuals with LLD to explore the
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Vitamin D Deficiency Participates in Depression of Patients with Diabetic Peripheral Neuropathy by Regulating the Expression of Pro-Inflammatory Cytokines Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-27 Jingjing Zhou, Dongfeng Li, Youmin Wang
Objective: Vitamin D deficiency is associated with patients with diabetic peripheral neuropathy (DPN), and low levels of vitamin D are common in patients with depression. Depression is common in DPN patients and the definite pathogenesis remains unclear. This study aimed to determine vitamin D deficiency in the onset of depression in DPN and evaluate the effect of vitamin D supplementation on depression
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Hormonal Changes in Women with Epilepsy Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-26 Qiwei Li, Zhiyun Zhang, Jiajia Fang
Abstract: Epilepsy is a prevalent neurological disorder among women globally, often requiring long-term treatment. Hormonal fluctuations in women with epilepsy (WWE) can have reciprocal effects on epilepsy and antiseizure medications (ASMs), posing significant challenges for WWE. Notably, WWE commonly experience endocrine alterations such as thyroid dysfunctions, low bone metabolism, and reproductive
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Comparative Analysis of Personality Traits in Major Depressive Disorder and Bipolar Disorder: Impact, Differences, and Associations with Symptoms Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-23 Tian Li, Ruinan Li, Lei Zhao, Yue Sun, Chuanyue Wang, Qijing Bo
Purpose: This cross-sectional study aimed to compare the personality traits of patients with major depressive disorder (MDD) and bipolar disorder (BD) with those of healthy individuals. The goal was to gain insight into the potential impact of personality traits on the development and manifestation of mood disorders. Methods: One hundred seventy-eight patients with mood disorders were analyzed as either
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Does Baseline Cognitive Function Predict the Reduction Rate in HDRS-17 Total Scores in First-Episode, Drug-Naïve Patients with Major Depressive Disorder? Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-23 Qingyan Jiao, Yeqing Dong, Xiaojuan Ma, Shiyi Suzy Ji, Xinyu Liu, Jian Zhang, Xia Sun, Dazhi Li, Xingguang Luo, Yong Zhang
Purpose: Major depressive disorder (MDD) is associated with worse cognitive functioning. We aim to examine the association between baseline cognitive functioning and the reduction rate in HDRS-17 total scores and to highlight the predictors of the reduction rate in HDRS-17 total scores in MDD with first-episode, drug-naïve (FED) patients. Patients and Methods: Ninety FED patients were recruited consecutively
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What Do Farmers Need for Suicide Prevention: Considerations for a Hard-to-Reach Population Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-22 Anna Scheyett, Ian Lee Marburger, Andrea Scarrow, Stephanie M Hollifield, Jennifer Ward Dunn
Purpose: Farmers have suicide rates much higher than the general population, with elevated mental health symptoms and high stress levels. Farmers are a hard-to-reach population due to occupational demands and a culture where conversations about mental health are often stigmatizing. This study explored ways to tailor suicide prevention strategies to unique characteristics of farmers by speaking with
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Identification and Analysis of ZIC-Related Genes in Cerebellum of Autism Spectrum Disorders Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-22 Heli Li, Jinru Cui, Cong Hu, Hao Li, Xiaoping Luo, Yan Hao
Objective: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with significant genetic heterogeneity. The ZIC gene family can regulate neurodevelopment, especially in the cerebellum, and has been implicated in ASD-like behaviors in mice. We performed bioinformatic analysis to identify the ZIC gene family in the ASD cerebellum. Methods: We explored the roles of ZIC family genes
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Association of Age and Response to Methylphenidate HCL Treatment in Adult ADHD: A Proton Magnetic Resonance Spectroscopy Study Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-20 Gonca Ayse Unal, Ayse Nur Inci Kenar
Purpose: This study investigated the age-dependent effects of methylphenidate (MPH) on brain metabolites including choline (Cho), N-acetyl aspartate (NAA) and creatine (Cr) levels in the dorsolateral prefrontal cortex (DLPFC), striatum, cerebellum, and anterior cingulate cortex (ACC) regions of the brain in adult patients with attention deficit hyperactivity disorder (ADHD). Patients and Methods: The
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Research Advancements on the Correlation Between Spontaneous Intracerebral Hemorrhage of Different Etiologies and Imaging Markers of Cerebral Small Vessel Disease Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-20 Yu-Tong Liu, Chun-Yan Lei, Lian-Mei Zhong
Objective: The purpose of this review is to identify the correlation between ICH and CSVD imaging markers under SMASH-U classification by searching and analyzing a large number of literatures in recent years, laying a theoretical foundation for future clinical research. At the same time, by collecting clinical data to evaluate patient prognosis, analyzing whether there are differences or supplements
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The Association between Acupuncture Therapy and the Risk of Disability Development in Dementia Patients: A Nationwide Cohort Study Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-20 Chia-Yu Huang, Mei-Yao Wu, Ming-Cheng Huang, Teng-Shun Yu, Peter Karl Mayer, Hung-Rong Yen
Purpose: Disability is the comorbidity of dementia for which there is no available preventive measure. The aim of this study was to investigate the association between acupuncture treatment and the risk of disability development in dementia patients. Patients and Methods: A cohort study was performed using a nationwide health database in Taiwan. The included dementia patients were divided into acupuncture
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Genetic Markers Associated with Postpartum Depression: A Review Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-15 Joshua Harry Chandra, Candy Kurniawan, Irma Melyani Puspitasari
Abstract: Postpartum depression (PPD) is a common illness in mothers after childbirth. PPD negatively affect the mother’s quality of life and the bond with the infant, which can interfere with the infant’s emotional, social, and cognitive development. PPD is caused by various biological and psychosocial factors. The aim of this review is to summarize the latest evidence of the associations between
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Lifestyle Influence on Mild Cognitive Impairment Progression: A Decision Tree Prediction Model Study Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-12 Jiwen Hou, Hua Jiang, Yan Han, Rong Huang, Xiang Gao, Wei Feng, Zongjun Guo
Purpose: This study assessed the influences of different lifestyle on mild cognitive impairment (MCI) progression and established a decision tree prediction model to analyse their predictive significance on MCI progression incidence. Patients and Methods: From October 2015 to February 2020,330 patients with MCI were recruited, and demographic and lifestyle information collected. They were followed
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Perspectives from Adults with Tourette Syndrome on Research Priorities and Registry Development: A Focus Group Study Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-09 David A Isaacs, Kemberlee Bonnet, Michelle R Eckland, Kimberly Markowitz, Maria Pena, David G Schlundt
Purpose: Adults with Tourette syndrome (TS) have worse mental health, physical health, and quality of life than the general population. The factors contributing to negative outcomes across multiple health domains in adults with TS remain uncertain, in part due to a lack of longitudinal studies in this population. In attempt to address these knowledge gaps, our center has initiated development of a
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Excess Mortality in Individuals with Autism Spectrum Disorder: A Population-Based Cohort Study Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-08 Yu-Hsin Huang, Shu-I Wu, Min-Jing Lee, Yi-Lung Chen, Yao-Hsu Yang, Ting-Yu Kuo, Tai-Hsin Hung, Michael E Dewey, Robert Stewart, Vincent Chin-Hung Chen
Purpose: Autism spectrum disorder (ASD) may be associated with increased mortality, but relevant findings have been inconsistent. The modifying effects of gender and intellectual disability on excess mortality in individuals with ASD are underexplored. Patients and Methods: Using Taiwan’s National Health Insurance Research Database and the National Death Registry, this population-based cohort study
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A Thematic Analysis Investigating the Inaugural Psychosis REACH Family Ambassador Peer Training Program Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-08 Akansha Vaswani-Bye, Chris McCain, Jennifer M Blank, Mackenzie E Tennison, Sarah L Kopelovich
Purpose: Caregivers of loved ones with psychosis are tasked with navigating a barren care landscape for their loved ones and for themselves. The dearth of resources they face has a negative impact on outcomes for caregivers and their loved ones. The Psychosis REACH program, based on principles from Cognitive Behavioral Therapy for psychosis was developed as a community-based resource for families to
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Characteristics of Oral-Gut Microbiota in Model Rats with CUMS-Induced Depression Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-05 Yan Li, Penghong Liu
Purpose: The diversity and composition of the oral and gut microbiota of depressed rats were analyzed to explore the microbiological etiology of major depressive disorder (MDD). Methods: The depressed rat model was established by inducing chronic unpredictable mild stress (CUMS). After the establishment of the model, body weight measurements and behavioral tests were conducted. The diversity and composition