-
Real‐World Healthcare Cost Savings and Reduced Relapse Rate with Off‐Label Rituximab versus Disease‐Modifying Treatments Approved for Relapsing–Remitting Multiple Sclerosis: A Nationwide Cost‐Effectiveness Study Ann. Neurol. (IF 11.2) Pub Date : 2024-03-26 Peter Alping, Martin Neovius, Fredrik Piehl, Thomas Frisell
ObjectiveAlthough off‐label use of rituximab is a common alternative to disease‐modifying therapies (DMTs) approved for multiple sclerosis (MS) in several countries, the impact of this on treatment cost‐effectiveness is not well known.MethodsWe evaluated the relative cost‐effectiveness of rituximab and MS‐approved DMTs in a register‐based cohort study of Swedish residents with relapsing–remitting MS
-
Pro‐Hemorrhagic Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Associated with NOTCH3 p.R75P Mutation with Low Vascular NOTCH3 Aggregation Property Ann. Neurol. (IF 11.2) Pub Date : 2024-03-23 Hiroyuki Ishiyama, Hyunjin Kim, Satoshi Saito, Soichi Takeda, Misa Takegami, Yumi Yamamoto, Soichiro Abe, Shinsaku Nakazawa, Tomotaka Tanaka, Kazuo Washida, Yoshiaki Morita, Seung‐Taek Oh, Hee‐Jae Jung, Jay Chol Choi, Yuriko Nakaoku, Jin Nakahara, Masatoshi Koga, Kazunori Toyoda, Kisaki Amemiya, Yoshihiko Ikeda, Kinta Hatakeyama, Ikuko Mizuta, Toshiki Mizuno, Kwang‐Kuk Kim, Masafumi Ihara
ObjectivesIntracerebral hemorrhage (ICH) and cerebral microbleeds (CMB) in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy are more common in East Asian populations than in people of white European ancestry. We hypothesized that the ethnic difference is explained by the East Asian‐specific NOTCH3 p.R75P mutation.MethodsThis retrospective observational study
-
Pathogenic Potential of Eomesodermin‐Expressing T‐Helper Cells in Neurodegenerative Diseases Ann. Neurol. (IF 11.2) Pub Date : 2024-03-22 Tomomi Kanazawa, Wakiro Sato, Ben J.E. Raveney, Daiki Takewaki, Atsuko Kimura, Hiromi Yamaguchi, Yuma Yokoi, Reiko Saika, Yuji Takahashi, Tsuneo Fujita, Shinji Saiki, Akira Tamaoka, Shinji Oki, Takashi Yamamura
Eomesodermin‐expressing (Eomes+) T‐helper (Th) cells show cytotoxic characteristics in secondary progressive multiple sclerosis. We found that Eomes+ Th cell frequency was increased in the peripheral blood of amyotrophic lateral sclerosis and Alzheimer's disease patients. Furthermore, granzyme B production by Th cells from such patients was high compared with controls. A high frequency of Eomes+ Th
-
Optimized Multilayer Perceptron for Sensorimotor Functional Mapping Based on a Few Minutes of Intracranial Electroencephalogram Data Ann. Neurol. (IF 11.2) Pub Date : 2024-03-20 Alwan Iktimal, Dennis D. Spencer, Rafeed Alkawadri
Using 6‐minute free‐running intracranial‐electroencephalogram (icEEG) during sleep, an optimized multilayer perceptron (MLP) neural network accurately maps the sensorimotor cortex (SM) and identifies the anterior lip of the central sulcus (CS) in intractable epilepsy patients. We calculated 6 performance metrics to evaluate the MLP's efficacy: accuracy, area under the curve (AUC), recall, precision
-
Reply to “Letter on Spasticity Predicts Motor Recovery in Motor Complete Spinal Cord Injury” Ann. Neurol. (IF 11.2) Pub Date : 2024-03-19 Sina Sangari, Bing Chen, Sara Hobbs, Amanda Olson, Alan Anschel, Ki Kim, David Chen, Allison Kessler, Allen W. Heinemann, Martin Oudega, Brian K. Kwon, Steven Kirshblum, James D. Guest, Monica A. Perez
-
Differential Cognitive Effects of Unilateral Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease Ann. Neurol. (IF 11.2) Pub Date : 2024-03-19 Victor A Del Bene, Roy C. Martin, Sarah A. Brinkerhoff, Joseph W. Olson, Matthew J. Nelson, Dario Marotta, Christopher L. Gonzalez, Kelly A. Mills, Vidyulata Kamath, Gary Cutter, Chris P. Hurt, Melissa Wade, Frank G. Robinson, J. Nicole Bentley, Barton L. Guthrie, Robert T. Knight, Harrison C. Walker
ObjectiveThe aim of this study was to investigate the cognitive effects of unilateral directional versus ring subthalamic nucleus deep brain stimulation (STN DBS) in patients with advanced Parkinson's disease.MethodsWe examined 31 participants who underwent unilateral STN DBS (left n = 17; right n = 14) as part of an National Institutes of Health (NIH)‐sponsored randomized, double‐blind, crossover
-
Mitochondrial Dysfunction of Peripheral Platelets as a Predictive Biomarker for Postoperative Delirium in Elderly Patients Ann. Neurol. (IF 11.2) Pub Date : 2024-03-19 Yan Yang, Wei Zhang, Yue Liu, Xin Liu, Jun Xie, Rui Xu, Yulin Huang, Jing Hao, Yu'e Sun, Xiaoping Gu, Zhengliang Ma
ObjectiveTo determine the association between the preoperative Bioenergetic Health Index (BHI) of platelets and the occurrence of postoperative delirium (POD) in elderly patients.MethodsElderly patients scheduled for major abdominal surgery under general anesthesia were included. The presence of POD was assessed within the 3 days after surgery. Seahorse XF analysis and transmission electron microscopy
-
Beyond the Final Heartbeat: Neurological Perspectives on Normothermic Regional Perfusion for Organ Donation after Circulatory Death Ann. Neurol. (IF 11.2) Pub Date : 2024-03-19 Matthew P. Kirschen, Ariane Lewis, Michael A. Rubin, Panayiotis N. Varelas, David M. Greer
Normothermic regional perfusion (NRP) has recently been used to augment organ donation after circulatory death (DCD) to improve the quantity and quality of transplantable organs. In DCD‐NRP, after withdrawal of life‐sustaining therapies and cardiopulmonary arrest, patients are cannulated onto extracorporeal membrane oxygenation to reestablish blood flow to targeted organs including the heart. During
-
Neuromuscular Ultrasound in Cervical Nerve Root Avulsion Ann. Neurol. (IF 11.2) Pub Date : 2024-03-19 Nicholas J Miller, James B Meiling, James B Caress, Michael S Cartwright
A 22-year-old man was injured in a high-speed motor vehicle collision, sustaining multiple limb fractures and pneumothoraxes. Immediately following the accident, he had difficulty moving his right upper limb. A brachial plexus injury was suspected. He was referred for electrodiagnostic studies (EDX) 3 months later, without imaging studies available for review. At the time of EDX, he described minimal
-
Furthering Female Faculty: An American Neurological Association/Association of University Professors of Neurology Perspective Ann. Neurol. (IF 11.2) Pub Date : 2024-03-19 L. John Greenfield, Shilpi Mittal, Sima I. Patel, Christa O'Hana S. Nobleza, Deborah Bradshaw
Potential Conflicts of Interest Nothing to report.
-
Accumulation of Lewy‐Related Pathology Starts in Middle Age: The Tampere Sudden Death Study Ann. Neurol. (IF 11.2) Pub Date : 2024-03-19 Eloise H Kok, Anders Paetau, Mika Martiskainen, Leo‐Pekka Lyytikäinen, Terho Lehtimäki, Pekka Karhunen, Liisa Myllykangas
When effective treatments against neurodegenerative diseases become a reality, it will be important to know the age these pathologies begin to develop. We investigated alpha‐synuclein pathology in brain tissue of the Tampere Sudden Death Study—unselected forensic autopsies on individuals living outside hospital institutions in Finland. Of 562 (16–95 years) participants, 42 were positive for Lewy‐related
-
Is High‐Frequency Activity at Seizure Onset Inhibitory? A Stereoelectroencephalographic Study of Motor Cortex Seizures Ann. Neurol. (IF 11.2) Pub Date : 2024-03-14 Hussam Shaker, Jian Li, Masako Kobayashi, Olesya Grinenko, Juan Bulacio, Richard M. Leahy, Patrick Chauvel
ObjectiveIn the era of stereoelectroencephalography (SEEG), many studies have been devoted to understanding the role of interictal high‐frequency oscillations. High‐frequency activity (HFA) at seizure onset has been identified as a marker of epileptogenic zone. We address the physiological significance of ictal HFAs and their relation to clinical semiology.MethodsWe retrospectively identified patients
-
Blood Pressure after Successful Endovascular Therapy: A Systematic Review and Meta‐Analysis of Randomized Control Trials Ann. Neurol. (IF 11.2) Pub Date : 2024-03-14 Khaled Gharaibeh, Nameer Aladamat, Adam T. Mierzwa, Rahul Rao, Hisham Alhajala, Sami Al Kasab, Mohammad Anadani, Richard Burgess, Syed Zaidi, Mouhammad Jumaa
ObjectiveThere are limited data evaluating the optimum blood pressure (BP) goal post mechanical thrombectomy (MT) and its effect on outcomes of patients with large vessel occlusions (LVO). The objective of this study was to compare the efficacy and safety of intensive versus conventional BP control after reperfusion with MT via a systematic review and meta‐analysis of randomized controlled trials (RCTs)
-
Cognitive Impairment Is Related to Glymphatic System Dysfunction in Pediatric Multiple Sclerosis Ann. Neurol. (IF 11.2) Pub Date : 2024-03-14 Monica Margoni, Elisabetta Pagani, Alessandro Meani, Paolo Preziosa, Damiano Mistri, Mor Gueye, Lucia Moiola, Massimo Filippi, Maria Assunta Rocca
ObjectiveThe aim of this study was to investigate whether, compared to pediatric healthy controls (HCs), the glymphatic system is impaired in pediatric multiple sclerosis (MS) patients according to their cognitive status, and to assess its association with clinical disability and MRI measures of brain structural damage.MethodsSixty‐five pediatric MS patients (females = 62%; median age = 15.5 [interquartile
-
Trigeminal Trophic Syndrome from Lateral Medullary Stroke Ann. Neurol. (IF 11.2) Pub Date : 2024-03-14 Gareth Zigui Lim, Jiekai Tan
Potential Conflicts of Interest Nothing to report.
-
Letter on Spasticity Predicts Motor Recovery in Motor Complete Spinal Cord Injury Ann. Neurol. (IF 11.2) Pub Date : 2024-03-12 Jing Chen
-
Lifetime Stressful Events Associated with Alzheimer's Pathologies, Neuroinflammation and Brain Structure in a Risk Enriched Cohort Ann. Neurol. (IF 11.2) Pub Date : 2024-03-11 Eleni Palpatzis, Muge Akinci, Pablo Aguilar-Dominguez, Marina Garcia-Prat, Kaj Blennow, Henrik Zetterberg, Margherita Carboni, Gwendlyn Kollmorgen, Norbert Wild, Karine Fauria, Carles Falcon, Juan Domingo Gispert, Marc Suárez-Calvet, Oriol Grau-Rivera, Gonzalo Sánchez-Benavides, Eider M. Arenaza-Urquijo
Along with the known effects of stress on brain structure and inflammatory processes, increasing evidence suggest a role of chronic stress in the pathogenesis of Alzheimer's disease (AD). We investigated the association of accumulated stressful life events (SLEs) with AD pathologies, neuroinflammation, and gray matter (GM) volume among cognitively unimpaired (CU) individuals at heightened risk of AD
-
Presynaptic Dopaminergic Imaging Characterizes Patients with REM Sleep Behavior Disorder Due to Synucleinopathy Ann. Neurol. (IF 11.2) Pub Date : 2024-03-11 Dario Arnaldi, Pietro Mattioli, Stefano Raffa, Matteo Pardini, Federico Massa, Alex Iranzo, Andres Perissinotti, Aida Niñerola-Baizán, Carles Gaig, Monica Serradell, Amaia Muñoz-Lopetegi, Gerard Mayà, Claudio Liguori, Mariana Fernandes, Fabio Placidi, Agostino Chiaravalloti, Karel Šonka, Petr Dušek, David Zogala, Jiri Trnka, Bradley F. Boeve, Toji Miyagawa, Val J. Lowe, Tomoyuki Miyamoto, Masayuki
To apply a machine learning analysis to clinical and presynaptic dopaminergic imaging data of patients with rapid eye movement (REM) sleep behavior disorder (RBD) to predict the development of Parkinson disease (PD) and dementia with Lewy bodies (DLB).
-
High‐Frequency Spinal Stimulation Suppresses Microglial Kaiso‐P2X7 Receptor Axis‐Induced Inflammation to Alleviate Neuropathic Pain in Rats Ann. Neurol. (IF 11.2) Pub Date : 2024-03-07 Jing Yu, Stanley Wong, Zhinan Lin, Zhiming Shan, Chaoyang Fan, Zhengyuan Xia, Martin Cheung, Xiaowei Zhu, Jessica Aijia Liu, Chi Wai Cheung
ObjectiveNeuropathic pain poses a persistent challenge in clinical management. Neuromodulation has emerged as a last‐resort therapy. Conventional spinal cord stimulation (Con SCS) often causes abnormal sensations and provides short analgesia, whereas high‐frequency spinal cord stimulation (HF SCS) is a newer therapy that effectively alleviates pain without paresthesia. However, the modes of action
-
Fostering Academia‐Industry Partnerships to Facilitate Therapeutic Discoveries in Neurology: The Role of ANA as a Catalyst Ann. Neurol. (IF 11.2) Pub Date : 2024-03-04 M. Elizabeth Ross, Dimitri Krainc, Ming Guo, M. Maral Mouradian, Rajiv R. Ratan
-
In Memoriam: Henry F. McFarland (1940–2024) Ann. Neurol. (IF 11.2) Pub Date : 2024-02-29 Daniel S. Reich
-
-
-
Epstein–Barr Virus Strongly Associates With Pediatric Multiple Sclerosis, But Not Myelin Oligodendrocyte Glycoprotein-Antibody-Associated Disease Ann. Neurol. (IF 11.2) Pub Date : 2024-02-27 Giulia Fadda, Carmen Yea, Julia O'Mahony, Patrick Waters, E. Ann Yeh, Ruth Ann Marrie, Douglas Arnold, Amit Bar-Or, Brenda Banwell
Reported rates of Epstein–Barr virus (EBV) seropositivity in children meeting multiple sclerosis (MS) diagnostic criteria are considerably lower than those reported in adult-onset MS, putting in question a requisite role for EBV in MS development. As prior work preceded recognition of myelin oligodendrocyte glycoprotein-associated disease (MOGAD), we assessed viral serologies in 251 children with incident
-
Role of the Exposome in Neurodegenerative Disease: Recent Insights and Future Directions Ann. Neurol. (IF 11.2) Pub Date : 2024-02-27 Stacey A. Sakowski, Emily J. Koubek, Kevin S. Chen, Stephen A. Goutman, Eva L. Feldman
Neurodegenerative diseases are increasing in prevalence and place a significant burden on society. The causes are multifactorial and complex, and increasing evidence suggests a dynamic interplay between genes and the environment, emphasizing the importance of identifying and understanding the role of lifelong exposures, known as the exposome, on the nervous system. This review provides an overview
-
Associations of 24‐Hour Rest‐Activity Rhythm Fragmentation, Cognitive Decline, and Postmortem Locus Coeruleus Hypopigmentation in Alzheimer's Disease Ann. Neurol. (IF 11.2) Pub Date : 2024-02-26 Maxime Van Egroo, Eus J.W. van Someren, Lea T. Grinberg, David A. Bennett, Heidi I.L. Jacobs
ObjectiveWhile studies suggested that locus coeruleus (LC) neurodegeneration contributes to sleep–wake dysregulation in Alzheimer's disease (AD), the association between LC integrity and circadian rest‐activity patterns remains unknown. Here, we investigated the relationships between 24‐hour rest‐activity rhythms, cognitive trajectories, and autopsy‐derived LC integrity in older adults with and without
-
Diet, Pace of Biological Aging, and Risk of Dementia in the Framingham Heart Study Ann. Neurol. (IF 11.2) Pub Date : 2024-02-26 Aline Thomas, Calen P. Ryan, Avshalom Caspi, Zhonghua Liu, Terrie E. Moffitt, Karen Sugden, Jiayi Zhou, Daniel W. Belsky, Yian Gu
ObjectivePeople who eat healthier diets are less likely to develop dementia, but the biological mechanism of this protection is not well understood. We tested the hypothesis that healthy diet protects against dementia because it slows the pace of biological aging.MethodsWe analyzed Framingham Offspring Cohort data. We included participants ≥60 years‐old, free of dementia and having dietary, epigenetic
-
Increased Cortical Thickness in Alzheimer's Disease Ann. Neurol. (IF 11.2) Pub Date : 2024-02-24 Tony X. Phan, Sheena Baratono, William Drew, Aaron M. Tetreault, Michael D. Fox, R. Ryan Darby,
Patients with Alzheimer's disease (AD) have diffuse brain atrophy, but some regions, such as the anterior cingulate cortex (ACC), are spared and may even show increase in size compared to controls. The extent, clinical significance, and mechanisms associated with increased cortical thickness in AD remain unknown. Recent work suggested neural facilitation of regions anticorrelated to atrophied regions
-
Ictal Central Apnea Is Predictive of Mesial Temporal Seizure Onset: An Intracranial Investigation Ann. Neurol. (IF 11.2) Pub Date : 2024-02-24 Nuria Lacuey, Blanca Talavera, Oman Magana‐Tellez, Oscar Mancera‐Páez, Norma Hupp, Xi Luo, Johnson P. Hampson, Jaison Hampson, M. R. Sandhya Rani, Manuela Ochoa‐Urrea, Omar A. Alamoudi, Stephen Melius, Sandipan Pati, Jay Gavvala, Nitin Tandon, John C. Mosher, Samden D. Lhatoo
ObjectiveIctal central apnea (ICA) is a semiological sign of focal epilepsy, associated with temporal and frontal lobe seizures. In this study, using qualitative and quantitative approaches, we aimed to assess the localizational value of ICA. We also aimed to compare ICA clinical utility in relation to other seizure semiological features of focal epilepsy.MethodsWe analyzed seizures in patients with
-
Effect of Statin Therapy on Cardiovascular Outcome in Stroke Patients with Low Baseline Low‐Density Lipoprotein Cholesterol Ann. Neurol. (IF 11.2) Pub Date : 2024-02-24 Yong Soo Kim, Han‐Gil Jeong, Jun Young Chang, Jun Yup Kim, Beom Joon Kim, Hee‐Joon Bae, Moon‐Ku Han
ObjectivesTo investigate whether post‐stroke statin therapy reduces subsequent major vascular events in statin‐naïve patients with pretreatment low‐density lipoprotein cholesterol (LDL‐C) below the recommended target (≤70 mg/dL for atherosclerotic stroke and ≤100 mg/dL for non‐atherosclerotic stroke) at stroke onset.MethodsPatients from an ongoing stroke registry who had an ischemic stroke between
-
Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Is Associated with HLA‐A*3303 and HLA‐DPB1*0501 Ann. Neurol. (IF 11.2) Pub Date : 2024-02-24 Yaqing Shu, Renliang Huang, Qihui Li, Yi Lu, Junping Yin, Huilu Li, Zhike Lan, Xiujun Zheng, Jinlong Ye, Youming Long, Zhanhang Wang, Li Xiao, Qiaomiao Zhou, Xu Liu, Ying Fu, Hao Chen, Juanjuan Chen, Yanxia Zhou, Juan Zhou, Liting Zhang, Jing Zhou, Ying Jiang, Fuhua Peng, Zhengqi Lu, Frank Petersen, Wei Qiu, Xinhua Yu
We determined the genetic association between specific human leucocyte antigen (HLA) loci and autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy. Our results showed that autoimmune GFAP astrocytopathy was associated with HLA‐A*3303 (odds ratio [OR] = 2.02, 95% confidence interval [CI] = 1.32–3.06, p = 0.00072, padj. = 0.046) and HLA‐DBP1*0501 (OR = 0.51, 95% CI = 0.36–0.71, p = 0.000048
-
Timing of Biomarker Changes in Sporadic Alzheimer's Disease in Estimated Years from Symptom Onset Ann. Neurol. (IF 11.2) Pub Date : 2024-02-24 Yan Li, Daniel Yen, Rachel D. Hendrix, Brian A. Gordon, Sibonginkhosi Dlamini, Nicolas R. Barthélemy, Andrew J. Aschenbrenner, Rachel L. Henson, Elizabeth M. Herries, Katherine Volluz, Kristopher Kirmess, Stephanie Eastwood, Matthew Meyer, Maren Heller, Lea Jarrett, Eric McDade, David M. Holtzman, Tammie L.S. Benzinger, John C. Morris, Randall J. Bateman, Chengjie Xiong, Suzanne E. Schindler
ObjectiveA clock relating amyloid positron emission tomography (PET) to time was used to estimate the timing of biomarker changes in sporadic Alzheimer disease (AD).MethodsResearch participants were included who underwent cerebrospinal fluid (CSF) collection within 2 years of amyloid PET. The ages at amyloid onset and AD symptom onset were estimated for each individual. The timing of change for plasma
-
Efficacy of Endovascular Thrombectomy in Acute Basilar Artery Occlusion with Low PC-ASPECTS: A Nationwide Prospective Registry-Based Study Ann. Neurol. (IF 11.2) Pub Date : 2024-02-21 Jun Young Chang, Ji Sung Lee, Wook-Joo Kim, Jee Hyun Kwon, Beom Joon Kim, Joon-Tae Kim, Jun Lee, Jae Kwan Cha, Dae-Hyun Kim, Yong-Jin Cho, Keun-Sik Hong, Soo Joo Lee, Jong-Moo Park, Kyusik Kang, Byung-Chul Lee, Kyung-Ho Yu, Sang-Hwa Lee, Chulho Kim, Kwang-Yeol Park, Dong-Eog Kim, Kyungbok Lee, Tai Hwan Park, Jay Chol Choi, Dong-Ick Shin, Sung-Il Sohn, Hee-Joon Bae, Moon-Ku Han
We evaluated the efficacy of endovascular thrombectomy (EVT) on the functional outcome of patients with acute basilar artery occlusion and low posterior circulation acute stroke prognosis early computed tomography score (PC-ASPECTS).
-
Cortical Thickness Patterns of Cognitive Impairment Phenotypes in Drug‐Resistant Temporal Lobe Epilepsy Ann. Neurol. (IF 11.2) Pub Date : 2024-02-23 Gadi Miron, Paul Manuel Müller, Louisa Hohmann, Frank Oltmanns, Martin Holtkamp, Christian Meisel, Claudia Chien
ObjectiveIn temporal lobe epilepsy (TLE), a taxonomy classifying patients into 3 cognitive phenotypes has been adopted: minimally, focally, or multidomain cognitively impaired (CI). We examined gray matter (GM) thickness patterns of cognitive phenotypes in drug‐resistant TLE and assessed potential use for predicting postsurgical cognitive outcomes.MethodsTLE patients undergoing presurgical evaluation
-
Seizure Cycles under Pharmacotherapy Ann. Neurol. (IF 11.2) Pub Date : 2024-02-21 Cecilia Friedrichs‐Maeder, Timothée Proix, Thomas K. Tcheng, Tara Skarpaas, Vikram R. Rao, Maxime O. Baud
ObjectiveThis study was undertaken to determine the effects of antiseizure medications (ASMs) on multidien (multiday) cycles of interictal epileptiform activity (IEA) and seizures and evaluate their potential clinical significance.MethodsWe retrospectively analyzed up to 10 years of data from 88 of the 256 total adults with pharmacoresistant focal epilepsy who participated in the clinical trials of
-
Associations of Serum Insulin and Related Measures With Neuropathology and Cognition in Older Persons With and Without Diabetes Ann. Neurol. (IF 11.2) Pub Date : 2024-02-21 Zoe Arvanitakis, Ana W. Capuano, Han Tong, Rupal I. Mehta, Frederick Anokye‐Danso, David A. Bennett, Steven E. Arnold, Rexford S. Ahima
ObjectiveTo examine associations of serum insulin and related measures with neuropathology and cognition in older persons.MethodsWe studied 192 older persons (96 with diabetes and 96 without, matched by sex and balanced by age‐at‐death, education, and postmortem interval) from a community‐based, clinical‐pathologic study of aging, with annual evaluations including neuropsychological testing (summarized
-
Levodopa Impairs the Energy Metabolism of the Basal Ganglia In Vivo Ann. Neurol. (IF 11.2) Pub Date : 2024-02-17 Jannik Prasuhn, Tanja Schiefen, Theresia Güber, Julia Henkel, Jan Uter, Julia Steinhardt, Britta Wilms, Norbert Brüggemann
One proposed mechanism of disease progression in Parkinson's disease includes the interplay of endogenous dopamine toxicity and mitochondrial dysfunction. However, the in-vivo effects of exogenous dopamine administration on cerebral bioenergetics are unknown.
-
White and Gray Matter Changes are Associated With Neurocognitive Decline in HIV Infection Ann. Neurol. (IF 11.2) Pub Date : 2024-02-16 Alice Chien, Tianxia Wu, Chuen-Yen Lau, Darshan Pandya, Amanda Wiebold, Brian Agan, Joseph Snow, Bryan Smith, Avindra Nath, Govind Nair
To investigate the relationship between neurocognitive deficits and structural changes on brain magnetic resonance imaging in people living with HIV (PLWH) with good virological control on combination antiretroviral therapy, compared with socioeconomically matched control participants recruited from the same communities.
-
Intensive Blood Pressure Treatment and Subclinical Brain Infarcts: A Secondary Analysis of SPRINT (Systolic Pressure Intervention Trial) Ann. Neurol. (IF 11.2) Pub Date : 2024-02-16 Kyle C. Kern, Ilya M. Nasrallah, R. Nick Bryan, Jeff Williamson, David M. Reboussin, Nicholas M. Pajewski, Clinton B. Wright
Subclinical brain infarcts (SBI) increase the risk for stroke and dementia, but whether they should be considered equivalent to symptomatic stroke when determining blood pressure targets remains unclear. We tested whether intensive systolic blood pressure (SBP) treatment reduced the risk of new SBI or stroke and determined the association between SBI and cognitive impairment.
-
Toward Individual Treatment in Cervical Artery Dissection: Subgroup Analysis of the TREAT-CAD Randomized Trial Ann. Neurol. (IF 11.2) Pub Date : 2024-02-16 Josefin E. Kaufmann, Henrik Gensicke, Sabine Schaedelin, Andreas R. Luft, Barbara Goeggel-Simonetti, Urs Fischer, Patrik Michel, Davide Strambo, Georg Kägi, Jochen Vehoff, Krassen Nedeltchev, Timo Kahles, Lars Kellert, Sverre Rosenbaum, Regina von Rennenberg, Christoph Riegler, David Seiffge, Hakan Sarikaya, Annaelle Zietz, Johannes Wischmann, Alexandros A. Polymeris, Martin Hänsel, Christoph Globas
Uncertainty remains regarding antithrombotic treatment in cervical artery dissection. This analysis aimed to explore whether certain patient profiles influence the effects of different types of antithrombotic treatment.
-
Microglial Reactivity Correlates with Presynaptic Loss Independent of β-Amyloid and Tau Ann. Neurol. (IF 11.2) Pub Date : 2024-02-14 Guoyu Lan, Xuhui Chen, Jie Yang, Pan Sun, Yue Cai, Anqi Li, Yalin Zhu, Zhen Liu, Shaohua Ma, Tengfei Guo
Triggering receptor expressed on myeloid cells-2 (TREM2) and progranulin (PGRN) are critical regulators of microglia activation and can be detected in cerebrospinal fluid (CSF). However, whether microglial reactivity is detrimental or neuroprotective for Alzheimer disease (AD) is still debatable.
-
Transcript Profiles of Microglia/Macrophage Cells at the Borders of Chronic Active and Subpial Gray Matter Lesions in Multiple Sclerosis Ann. Neurol. (IF 11.2) Pub Date : 2024-02-12 Anthony Chomyk, Rikki Kucinski, Jihye Kim, Emilie Christie, Kaitlyn Cyncynatus, Zachary Gossman, Zhihong Chen, Brian Richardson, Mark Cameron, Tim Turner, Ranjan Dutta, Bruce Trapp
Microglia/macrophages line the border of demyelinated lesions in both cerebral white matter and the cortex in the brains of multiple sclerosis patients. Microglia/macrophages associated with chronic white matter lesions are thought to be responsible for slow lesion expansion and disability progression in progressive multiple sclerosis, whereas those lining gray matter lesions are less studied. Profiling
-
The Melanocortin and Endorphin Neuropeptides in Patients with Restless Legs Syndrome Ann. Neurol. (IF 11.2) Pub Date : 2024-02-03 Brian B. Koo, Ahmed Abdelfattah, Athar Eysa, Lingeng Lu
Based upon similarities between the urge to move and sensory discomfort of restless legs syndrome (RLS) and properties of melanocortin hormones, including their incitement of movement and hyperalgesia, we assessed plasma and cerebrospinal fluid (CSF) α-melanocyte-stimulating hormone (α-MSH) and β-endorphin in RLS patients and controls.
-
Health and Healthcare Disparities in Pediatric Epilepsy in the United States: A Scoping Review Ann. Neurol. (IF 11.2) Pub Date : 2024-02-01 Karen L. Skjei, Christopher Beatty, Sonal Bhatia, Rebecca Garcia-Sosa, Charuta Joshi, Shital Patel, Nilika S. Singal, Connie Taylor, Imelda L. Vetter, Janelle L. Wagner
Health disparities impact epilepsy care in children. Previous efforts to summarize data in this population have been limited. This study sought to understand how this information exists in the literature and identify gaps in knowledge.
-
Giving Breath to Motor Neurons: Noninvasive Mechanical Ventilation Slows Disease Progression in Amyotrophic Lateral Sclerosis Ann. Neurol. (IF 11.2) Pub Date : 2024-01-29 Maurizio Grassano, Emanuele Koumantakis, Umberto Manera, Antonio Canosa, Rosario Vasta, Francesca Palumbo, Giuseppe Fuda, Paolina Salamone, Giulia Marchese, Federico Casale, Lorena Charrier, Gabriele Mora, Cristina Moglia, Andrea Calvo, Adriano Chiò
Noninvasive mechanical ventilation (NIMV) improves amyotrophic lateral sclerosis (ALS) quality of life and survival. However, data about its effect on disease progression are still lacking. Here, we test whether NIMV use changed the rate of functional decline among ALS patients.
-
Seven Strategies to Integrate Equity within Translational Research in Neurology Ann. Neurol. (IF 11.2) Pub Date : 2024-01-25 Karlo J. Lizarraga, Tirisham Gyang, Richard T. Benson, Gretchen L. Birbeck, Karen C. Johnston, Walter Royal, Ralph L. Sacco, Benjamin Segal, Barbara G. Vickrey, Robert C. Griggs, Robert G. Holloway
The rapidly accelerating translation of biomedical advances is leading to revolutionary therapies that are often inaccessible to historically marginalized populations. We identified and synthesized recent guidelines and statements to propose 7 strategies to integrate equity within translational research in neurology: (1) learn history; (2) learn about upstream forces; (3) diversify and liberate; (4)
-
Correction to “Do Early Relapses Predict the Risk of Long-Term Relapsing Disease in an Adult and Paediatric Cohort with MOGAD?” Ann. Neurol. (IF 11.2) Pub Date : 2024-01-18
Chen B, Gomez-Figueroa E, Redenbaugh V, et al. Do Early Relapses Predict the Risk of Long-Term Relapsing Disease in an Adult and Paediatric Cohort with MOGAD? Ann Neurol 2023;94:508–517. In the above article, an author was inadvertently omitted from the list of authors. The author below has now been added as the tenth author in the author list. Friedemann Paul, MD Experimental and Clinical Research
-
Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease Ann. Neurol. (IF 11.2) Pub Date : 2024-01-05 Jeffery M. Vance, Lindsay A. Farrer, Yadong Huang, Carlos Cruchaga, Bradley T. Hyman, Margaret A. Pericak-Vance, Alison M. Goate, Michael D. Greicius, Anthony J. Griswold, Jonathan L. Haines, Julia TCW, Gerard D. Schellenberg, Li-Huei Tsai, Joachim Herz, David M. Holtzman
Alzheimer's disease (AD) is the most common neurodegenerative disorder and one of the leading causes of disability worldwide. The apolipoprotein E4 gene (APOE4) is the strongest genetic risk factor for AD. In 2023, the APOE4 National Institute on Aging/Alzheimer's Disease Sequencing Project working group came together to gather data and discuss the question of whether to reduce or increase APOE4 as
-
High Levels of Perivascular Inflammation and Active Demyelinating Lesions at Time of Death Associated with Rapidly Progressive Multiple Sclerosis Disease Course: A Retrospective Postmortem Cohort Study Ann. Neurol. (IF 11.2) Pub Date : 2023-12-27 Richard Nicholas, Roberta Magliozzi, Damiano Marastoni, Owain Howell, Federico Roncaroli, Paolo Muraro, Richard Reynolds, Tim Friede
Analysis of postmortem multiple sclerosis (MS) tissues combined with in vivo disease milestones suggests that whereas perivascular white matter infiltrates are associated with demyelinating activity in the initial stages, leptomeningeal immune cell infiltration, enriched in B cells, and associated cortical lesions contribute to disease progression. We systematically examine the association of inflammatory
-
Artery of Percheron Stroke Ann. Neurol. (IF 11.2) Pub Date : 2023-12-26 Giandor Saltz, Askiel Bruno, Fenwick Nichols
Potential Conflicts of Interest Nothing to report.
-
Intravenous Thrombolysis before Complete Angiographic Reperfusion: Beyond Angiographic Assessment to Target Microvascular Obstruction? Ann. Neurol. (IF 11.2) Pub Date : 2023-12-26 Benjamin Gory, Stephanos Finitsis, Jean-Marc Olivot, Sébastien Richard, Gaultier Marnat, Igor Sibon, Alain Viguier, Christophe Cognard, Mikael Mazighi, Angel Chamorro, Bertrand Lapergue, Benjamin Maïer
Recent data have suggested that ineffective tissue reperfusion despite successful angiographic reperfusion was partly responsible for unfavorable outcomes after endovascular therapy (EVT) and might be modulated by intravenous thrombolysis (IVT) use before EVT. To specifically decipher the effect played by IVT before EVT, we compared the clinical and safety outcomes of patients who experienced a complete
-
Alterations of Cortical Structure and Neurophysiology in Parkinson's Disease Are Aligned with Neurochemical Systems Ann. Neurol. (IF 11.2) Pub Date : 2023-12-26 Alex I. Wiesman, Jason da Silva Castanheira, Edward A. Fon, Sylvain Baillet,
Parkinson's disease (PD) affects the structural integrity and neurophysiological signaling of the cortex. These alterations are related to the motor and cognitive symptoms of the disease. How these changes are related to the neurochemical systems of the cortex is unknown.
-
Cerebral Small Vessel Disease Burden for Bleeding Risk during Antithrombotic Therapy: Bleeding with Antithrombotic Therapy 2 Study Ann. Neurol. (IF 11.2) Pub Date : 2023-12-25 Kanta Tanaka, Kaori Miwa, Masatoshi Koga, Sohei Yoshimura, Kenji Kamiyama, Yoshiki Yagita, Yoshinari Nagakane, Haruhiko Hoshino, Tadashi Terasaki, Yasushi Okada, Yusuke Yakushiji, Shinichi Takahashi, Toshihiro Ueda, Yasuhiro Hasegawa, Masayuki Shiozawa, Makoto Sasaki, Kohsuke Kudo, Jun Tanaka, Masashi Nishihara, Yoshitaka Yamaguchi, Kyohei Fujita, Yuko Honda, Hiroyuki Kawano, Toshihiro Ide, Takeshi
This study was undertaken to determine the excess risk of antithrombotic-related bleeding due to cerebral small vessel disease (SVD) burden.
-
Correction to Lyden P, Pryor KE, Coffey CS, et al. Final results of the RHAPSODY trial: a multi-center, phase 2 trial using a continual reassessment method to determine the safety and tolerability of 3K3A-APC, a recombinant variant of human activated protein C, in combination with tissue plasminogen activator, mechanical thrombectomy or both in moderate to severe acute ischemic stroke. Ann Neurol 2019;85:125–136 Ann. Neurol. (IF 11.2) Pub Date : 2023-12-21
In the copyediting for our paper, an extra line space was inserted in the last section of the Table giving the times to treatment for the two groups. This pushed the numbers for each category down one line. In addition, the timing until first treatment for the different groups (tPA, thrombectomy, tPA + thrombectomy) may not have been sufficiently clear without sample sizes and p values. The Table should
-
Limitations and Future Directions in Sex, Sexuality, and Gender Diverse Research in Neurology Ann. Neurol. (IF 11.2) Pub Date : 2023-12-19 Lennox Byer, Casey Orozco-Poore, Nicole Rosendale
Sex, sexuality, and gender diversity is understudied and underserved in neurology. Neurology research inclusive of LGBTQIA+ (lesbian, gay, bisexual, transgender, queer, intersex, asexual) people is limited. Existing research struggles with a paucity of neurology studies collecting sex, sexuality, and gender diverse (SSGD) data, conflation of sex and gender, lack of precision in measures, neglect of
-
Long-Term Downregulation of the Sodium Channel Gene Scn8a Is Therapeutic in Mouse Models of SCN8A Epilepsy Ann. Neurol. (IF 11.2) Pub Date : 2023-12-19 Sophie F. Hill*, Wenxi Yu*, Julie Ziobro, Sanjna Chalasani, Faith Reger, Miriam H. Meisler
De novo mutations of the voltage-gated sodium channel gene SCN8A cause developmental and epileptic encephalopathy (DEE). Most pathogenic variants result in gain-of-function changes in activity of the sodium channel Nav1.6, poorly controlled seizures, and significant comorbidities. In previous work, an antisense oligonucleotide (ASO) reduced Scn8a transcripts and increased lifespan after neonatal administration
-
Gene–Environment Interactions for Parkinson's Disease Ann. Neurol. (IF 11.2) Pub Date : 2023-12-19 Alexandra Reynoso, Roberta Torricelli, Benjamin Meir Jacobs, Jingchunzi Shi, Stella Aslibekyan, Lucy Norcliffe-Kaufmann, Alastair J Noyce, Karl Heilbron
Parkinson's disease (PD) is a neurodegenerative disorder with complex etiology. Multiple genetic and environmental factors have been associated with PD, but most PD risk remains unexplained. The aim of this study was to test for statistical interactions between PD-related genetic and environmental exposures in the 23andMe, Inc. research dataset.
-
Ictal Arterial Spin Labeling–Magnetic Resonance Imaging Identifies Seizure Onset Zone in Epilepsia Partialis Continua Ann. Neurol. (IF 11.2) Pub Date : 2023-12-18 Nathan T. Cohen, Ersida Buraniqi, Jacklyn D. Smith, L. Gilbert Vezina, William D. Gaillard
Potential Conflicts of Interest Nothing to report.
-
Biomarker Qualification for Neurofilament Light Chain in Amyotrophic Lateral Sclerosis: Theory and Practice Ann. Neurol. (IF 11.2) Pub Date : 2023-12-18 Michael Benatar, Lyle W. Ostrow, Joseph W Lewcock, Frank Bennett, Jeremy Shefner, Robert Bowser, Paul Larkin, Lucie Bruijn, Joanne Wuu
To explore whether the utility of neurofilament light chain (NfL), as a biomarker to aid amyotrophic lateral sclerosis (ALS) therapy development, would be enhanced by obtaining formal qualification from the US Food and Drug Administration for a defined context-of-use.
-
Risk of Multiple Sclerosis in People Living with HIV: An International Cohort Study Ann. Neurol. (IF 11.2) Pub Date : 2023-12-14 Kyla A. McKay, José M. A. Wijnands, Ali Manouchehrinia, Feng Zhu, Paul Sereda, Jenny Li, Monica Ye, Jason Trigg, Katherine Kooij, Anna Mia Ekström, Magnus Gisslén, Jan Hillert, Robert S. Hogg, Helen Tremlett, Elaine Kingwell
There has been interest in a possible negative association between HIV and multiple sclerosis (MS). We aimed to compare the risk of MS in a cohort of individuals living with HIV to that in the general population.