样式: 排序: IF: - GO 导出 标记为已读
-
Switching from natalizumab to an anti-CD20 monoclonal antibody in relapsing remitting multiple sclerosis: A systematic review Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-04-19 Justin D. Brown, Benjamin T. Muston, Jennifer Massey
Use of natalizumab (NTZ) is precluded in many Multiple Sclerosis (MS) patients by the risk of progressive multifocal leukoencephalopathy (PML). Regardless, some patients may commence natalizumab for short term disease control in spite of being seropositive, and others may seroconvert whilst on treatment. In these circumstances, discontinuation of NTZ should not occur until a clear exit strategy is
-
Health-related quality of life and utilities among Lebanese patients with Multiple Sclerosis: A cross-sectional study Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-04-16 Jalal Dahham, Mickaël Hiligsmann, Ingrid Kremer, Samia J. Khoury, Hala Darwish, Hassan Hosseini, Souheil Hallit, Silvia Evers, Rana Rizk
This study assessed the Health-Related Quality of Life (HRQoL) and utilities of Multiple Sclerosis (MS) patients in Lebanon using generic and MS-specific QoL instruments, categorized by disease severity, and explored factors associated with HRQoL. This was a cross-sectional, retrospective HRQoL study collecting data through face-to-face interviews using the EQ-5D-5 L and the Multiple Sclerosis International
-
Focusing on neural mechanisms of exercise training benefits in multiple sclerosis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-04-16 Brian M. Sandroff, Robert W. Motl, Amber Salter
Exercise training (ET) should be a mainstay of comprehensive care in multiple sclerosis (MS), yet there is reluctance regarding its implementation among healthcare providers. This reluctance has its roots in the lack of evidence from randomized controlled trials (RCTs) that provide a neurobiological mechanism for beneficial outcomes. We argue that ET training is efficacious for improving mobility and
-
Rituximab-induced gut microbiota changes in Chinese neuromyelitis optica spectrum disorders Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-04-16 Hao Chen, Zubing Xu, Yu Zhou, Yu-huan Jiang, Jin Chen, Yingqiong Xiong, Meihong Zhou, Xiaomu Wu, Daojun Hong
Recent evidence shows that immunosuppressive agents can affect the gut microbiota in autoimmune diseases. However, the relationship between the gut microbiome and B-cell depletion immunotherapy in neuromyelitis optica spectrum disorder (NMOSD) remains poorly understood. To evaluate the distinct intestinal microbial patterns and serum cytokine levels after short-term rituximab treatment (three months)
-
Latent tuberculosis prevalence, diagnosis and treatment in Multiple Sclerosis as a strategy for reducing infection reactivation during immunosuppressant therapy Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-04-15 Gelvana Flávio Barreto Reis, Andrea de Carvalho Anacleto Ferrari de Castro, Eitan Naaman Berezin
Tuberculosis is an infectious disease with a risk of reactivation in Multiple Sclerosis patients on immunosuppressant therapy. Diagnosis and treatment of Latent Tuberculosis Infection (LTBI) prevents the infection. To diagnose and treat LTBI in Multiple Sclerosis (MS). Cross-sectional study of the prevalence and treatment of LTBI in MS, between February 2021 and June 2023. LTBI was defined as an absence
-
Open access publishing and the future of scientific communication Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-04-15 Christopher H Hawkes, Gavin Giovannoni, Jeanette Lechner-Scott, Michael Levy, Ann Yeh
-
Leukocyte telomere length in multiple sclerosis: relationship between disability severity and pregnancy history Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-04-10 Michael Zhong, Sabrina Salberg, Sandeep Sampangi, Anneke van der Walt, Helmut Butzkueven, Richelle Mychasiuk, Vilija Jokubaitis
Aging-related processes contribute to neurodegeneration and disability in multiple sclerosis (MS). Biomarkers of biological aging such as leukocyte telomere length (LTL) could help personalise prognosis. Pregnancy has been shown to be protective against disability accumulation in women with MS, though it is unclear if this effect relates to aging mechanisms or LTL. This study aimed to cross-sectionally
-
Predicting the conversion from clinically isolated syndrome to multiple sclerosis: An explainable machine learning approach Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-04-09 Saeid Rasouli, Mohammad Sedigh Dakkali, Reza Azarbad, Azim Ghazvini, Mahdi Asani, Zahra Mirzaasgari, Mohammed Arish
Predicting the conversion of clinically isolated syndrome (CIS) to clinically definite multiple sclerosis (CDMS) is critical to personalizing treatment planning and benefits for patients. The aim of this study is to develop an explainable machine learning (ML) model for predicting this conversion based on demographic, clinical, and imaging data. The ML model, Extreme Gradient Boosting (XGBoost), was
-
Predictive factors and screening strategy for obstructive sleep apnea in patients with advanced multiple sclerosis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-04-09 C Cousin, J Di Maria, S Hartley, I Vaugier, V Delord, D Bensmail, H Prigent, A Léotard
Obstructive sleep apnea (OSA) screening questionnaires have been evaluated in Multiple Sclerosis (MS) but not yet validated in patients with advanced disease. The aim of this study is to identify OSA predictive factors in advanced MS and to discuss screening strategies. Oximetry data from 125 patients were retrospectively derived from polysomnographic reports. Univariate and multivariate analysis were
-
Diet and omega-3 and vitamin D supplement use predict five-year fatigue and disability trajectories in people with multiple sclerosis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-04-08 Xin Lin, Amin Zarghami, George A Jelinek, Steve Simpson-Yap, Sandra Neate, Nupur Nag
Fatigue and disability are indicators of disease progression experienced by many people with multiple sclerosis (pwMS). Understanding trajectories of these outcomes, and their predictors, may provide insight to potential interventions for MS management. Survey data from 839 pwMS from the Health Outcomes and Lifestyle in pwMS study were analysed. Fatigue was defined as mean Fatigue Severity Scale >5
-
SARS-CoV-2 infection increases long-term multiple sclerosis disease activity and all-cause mortality in an underserved inner-city population Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-04-08 Roham Hadidchi, Stephen H. Wang, David Rezko, Sonya Henry, Patricia K. Coyle, Tim Q. Duong
Although certain subsets patients with multiple sclerosis (MS), an immune-mediated disorder, are at higher risk of worse acute COVID-19 outcomes compared to the general population, it is not clear whether SARS-CoV-2 infection impacts long-term outcomes compared with MS patients without COVID-19 infection. This study investigated MS disease activity and mortality 3.5 years post SARS-CoV-2 infection
-
Cognitive impairment and its association with clinical variables in Mexican persons with neuromyelitis optica spectrum disorder Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-04-08 Verónica Rivas-Alonso, Jairo Cáceres, Edwin Ramírez-Benítez, Rodolfo Solís-Vivanco
Cognitive impairment has a substantial impact on the daily function of people living with demyelinating diseases. However, the study of cognitive failures and their association with clinical variables in people suffering from neuromyelitis optica spectrum disorder (NMOSD) has been scarce, especially in the latin american (Mexican) population at early and middle stages of the disease. We applied the
-
Artificial intelligence in multiple sclerosis management: Challenges in a new era Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-04-08 Sebastián Rodríguez
-
Event-related desynchronization and synchronization in multiple sclerosis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-04-04 Benjamin Bardel, Moussa A. Chalah, Ruben Bensais-Rueda, Alain Créange, Jean-Pascal Lefaucheur, Samar S. Ayache
Motor preparation and execution can be impaired in patients with multiple sclerosis (pwMS). These neural processes can be assessed using electroencephalography (EEG). During a self-paced movement, EEG signal amplitude decreases before movement (event-related desynchronization, ERD) and increases after movement (event-related synchronization, ERS). To reappraise ERD/ERS changes in pwMS compared to healthy
-
Assessment of dietary intake and its inflammatory potential in persons with pediatric-onset multiple sclerosis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-04-04 Sama Bitarafan, Feng Zhu, Ali Mirza, Charles N Bernstein, Gary Van Domselaar, Ruth Ann Marrie, E. Ann Yeh, Yinshan Zhao, Brenda Banwell, Emmanuelle Waubant, Helen Tremlett
To compare diet and the modified dietary inflammatory index (mDII) between individuals with pediatric-onset multiple sclerosis (PoMS), monophasic acquired demyelinating syndromes (monoADS), and controls. The association between diet, mDII, and disease status was examined in 131 individuals with PoMS/monoADS/controls (38/45/48) using logistic regression. The associations between diet and PoMS were modest
-
Prevalence of primary headaches in multiple sclerosis patients Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-04-03 Maged Abdel Naseer, Hatem Samir Shehata, Sarah Khalil, Amr Mohamed Fouad, Hend Abdelghany
Multiple sclerosis (MS) is the most common immune-mediated inflammatory disease of the central nervous system. It is characterized by symptoms such as visual disturbances, paresis with spasticity, paresthesia, numbness, and fatigue. However, several studies have shown a high prevalence of headaches in individuals with MS. Migraine and tension-type headaches are the most frequent types of headaches
-
Effects of photobiomodulation therapy on muscle function in individuals with multiple sclerosis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-04-01 Mitra Rouhani, Miguel Tolentino, Jeri-Anne Lyons, Alexander V. Ng
In people with multiple sclerosis (pwMS), muscle fatigue and weakness are common issues that can interfere with daily activities. Photobiomodulation therapy (PBMT), comprising light in a 600–1100 nm bandwidth, is a low-level laser therapy thought to improve muscle performance in non-disease populations, in part, by improving mitochondrial function and thus, might be beneficial in pwMS. Given this potential
-
Assessing multimodal emotion recognition in multiple sclerosis with a clinically accessible measure Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-04-01 Jordan D. Pumphrey, Sanghamithra Ramani, Tamanna Islam, Jason A. Berard, Matthew Seegobin, Jennifer M. Lymer, Mark S. Freedman, Jing Wang, Lisa A.S. Walker
-
FCGR3A-V158F gene polymorphism: A potential predictor for rituximab dosing optimization in Chinese patients with neuromyelitis optica spectrum disorder Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-04-01 Lei Cui, Jinsong Jiao, Yeqiong Zhang, Renbin Wang, Dantao Peng, Yujuan Jiao, Weihe Zhang
Rituximab (RTX), an anti-CD20 monoclonal antibody, has shown promise in managing neuromyelitis optica spectrum disorders (NMOSD) by depleting B cells and reducing relapses. However, there is no consensus on the optimal RTX dosing regimen, and genetic factors, such as polymorphism, may influence treatment outcomes. This study investigates how FCGR3A-V158F genotypes influence RTX efficacy in Chinese
-
Ocrelizumab B cell depletion has no effect on HERV RNA expression in PBMC in MS patients Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-30 Rachael Tarlinton, Radu Tanasescu, Claire Shannon-Lowe, Bruno Gran
Epstein barr virus (EBV) infection of B cells is now understood to be one of the triggering events for the development of Multiple Sclerosis (MS), a progressive immune-mediated disease of the central nervous system. EBV infection is also linked to expression of human endogenous retroviruses (HERVs) of the HERV-W group, a further risk factor for the development of MS. Ocrelizumab is a high-potency disease-modifying
-
Passive assessment of tapping speed through smartphone is useful for monitoring multiple sclerosis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-30 Juan Luis Chico-Garcia, Raquel Sainz-Amo, Enric Monreal, Fernando Rodriguez-Jorge, Susana Sainz de la Maza, Jaime Masjuan, Luisa María Villar, Lucienne Costa-Frossard França
Continuously acquired smartphone keyboard interactions may be useful to monitor progression in multiple sclerosis (MS). We aimed to study the correlation between tapping speed (TS), measured as keys/s, and baseline disability scales in patients with MS. Single-center prospective study in patients with MS. We passively assessed TS during first week, measured by an “in house” smartphone application.
-
Efficacy and safety of ocrelizumab in patients with relapsing multiple sclerosis: Real-world experience of two Swiss multiple sclerosis centers Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-30 L Diem, A Ovchinnikov, C Friedli, H Hammer, N Kamber, A Chan, A Salmen, O Findling, R Hoepner
Ocrelizumab (OCR) is a humanized monoclonal antibody directed against CD-20 positive lymphocytes, mainly B-lymphocytes. OCR is approved for treatment of primary progressive (PPMS) and relapsing multiple sclerosis (RMS). This study aims to provide real-world safety and efficacy data of people with RMS treated with OCR in two Swiss Multiple Sclerosis (MS) centers. We have conducted a retrospective data
-
Cognitive and psychopathological features of neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody-associated disease: A narrative review Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-30 Christina Kazzi, Rubina Alpitsis, Terence J. O'Brien, Charles B. Malpas, Mastura Monif
Clinicians are becoming increasingly aware of the cognitive and psychopathological consequences of neurological diseases, which were once thought to manifest with motor and sensory impairments only. The cognitive profile of multiple sclerosis, in particular, is now well-characterised. Similar efforts are being made to better characterise the cognitive profile of other central nervous system inflammatory
-
Structural and functional correlates of disability, motor and cognitive performances in multiple sclerosis: Focus on the globus pallidus Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-29 Francesco Romanò, Paola Valsasina, Elisabetta Pagani, Alice De Simone, Emma Parolin, Massimo Filippi, Maria A. Rocca
To explore structural and functional alterations of external (GPe) and internal (GPi) globus pallidus in people with multiple sclerosis (pwMS) compared to healthy controls (HC) and analyze their relationship with measures of clinical disability, motor and cognitive impairment. Sixty pwMS and 30 HC comparable for age and sex underwent 3.0T MRI, including conventional, diffusion tensor MRI and resting
-
Traumatic brain injury, race, ethnicity and cognition in newly diagnosed persons with multiple sclerosis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-25 Jemima Akinsanya, Jessica B. Smith, Annette Langer-Gould
-
Where does multiple sclerosis come from? Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-23 VE Maltby, RJ Scott, G Giovannoni, CH Hawkes, M Levy, EA Yeh, J Lechner-Scott
-
The clinical and radiological features and prevalence of Neuro-Behçet's Disease: A retrospective cohort multicenter study in Saudi Arabia Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-20 Seraj Makkawi, Danya Aljafari, Rawaf Alsharif, Hadeel Maaddawi, Alhanouf Alwagdani, Talal Aljumah, Ziyad Alghweinem, Sultan Alshehri, Osama Khojah, Aisha Halawani, Reem Ahmed Adas, Ahmad Abulaban, Yaser Al Malik
Neuro-Behçet's disease (NBD) is defined as primary neurological involvement in patients with systemic symptoms of BD. The variety of clinical presentations seen in NBD and the long list of similar conditions make diagnosis challenging. This retrospective study aimed to estimate the prevalence and describe neurological involvement in patients with Behçet's disease who presented to King Abdulaziz Medical
-
Functional electrical stimulation combined with voluntary cycling accentuates VO2 response in people with severe multiple sclerosis: A pilot study Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-20 Suzanne Máté, Nicholas Corr, Daniel Hackett, Michael Barnett, Maria Fiatarone Singh, Ché Fornusek
Lower limb muscle weakness and reduced balance due to disease progression in multiple sclerosis (MS) may make robust aerobic exercise difficult. Functional electrical stimulation (FES) cycling combined with voluntary cycling may allow people with severe MS to enhance the intensity of aerobic exercise. The aim of this study was to investigate the cardiorespiratory, power, and participant-reported perceptions
-
Blood sphingolipid as a novel biomarker in patients with neuromyelitis optica spectrum disorder Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-20 Hyunjin Kim, Hwa Jung Kim, Jungmin So, Ji Yon Kim, Hee-Jae Jung, Seungmi Kim, Dayoung Seo, Hyun-Ji Kim, Ha Eun Song, Young-Min Lim, Hyun Ju Yoo, Eun-Jae Lee
Sphingolipids are signaling molecules and structural components of the axolemma and myelin sheath. Plasma sphingolipid levels may reflect disease status of neuromyelitis optica spectrum disorder (NMOSD). We aimed to examine plasma sphingolipids as disease severity biomarkers for NMOSD and compare their characteristics with those of serum neurofilament light chain (sNfL) and glial fibrillary acidic
-
The measurement of fatigability severity in individuals with multiple sclerosis and healthy controls Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-20 Mutasim D. Alharbi, Fayaz Khan
Multiple Sclerosis (MS) is a chronic disease that substantially diminishes one's ability to undertake daily living activities. Fatigue has been reported by at least 80 % of persons with MS (PwMS). Yet, little is known concerning the quantification of fatigability using prolonged walking tests. To compare fatigability severity measures using the 10-minute walk test for PwMS against age- and gender-matched
-
Brain and spinal cord atrophy in NMOSD and MOGAD: Current evidence and future perspectives Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-19 L. Lorefice, R. Cortese
Neuromyelitis optica spectrum disorder (NMOSD) is a severe form of inflammation of the central nervous system (CNS) including acute myelitis, optic neuritis and brain syndrome. Currently, the classification of NMOSD relies on serologic testing, distinguishing between seropositive or seronegative anti-aquaporin-4 antibody (AQP4) status. However, the situation has recently grown more intricate with the
-
Evidence of disease activity during pregnancy and post-partum in MS patients treated with high-efficacy therapies Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-19 Oussama Sahloul, Céline Louapre, Ysoline Beigneux, Catherine Lubetzki, Elisabeth Maillart, Thomas Roux
Multiple sclerosis (MS) predominantly affects women of childbearing age. Due to the risk of teratogenicity, women with active multiple sclerosis (MS) who require high-efficacy therapies (HET) may need to discontinue treatment during pregnancy. Fingolimod and Natalizumab withdrawal increases the risk of disease reactivation, a risk not commonly associated with anti-CD20 therapies. However, comparative
-
Backwards walking speed reserve in persons with multiple sclerosis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-19 Patrick G. Monaghan, Michael VanNostrand, Nora E. Fritz
Decreased gait speed is common in persons with Multiple Sclerosis (PwMS) and has been associated with elevated fall risk. The walking speed reserve (WSR) indicates the ability to increase gait speed on demand and has previously been examined in PwMS. Backward walking is a sensitive measure of fall risk in PwMS; however, no studies have reported on the utility of backward walking speed reserve (BW-WSR)
-
Multi-actor system dynamics in access to disease-modifying treatments for multiple sclerosis in Southeast Asia: A regional survey and suggestions for improvement Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-18 Shanthi Viswanathan, Lavanya Vijayasingham, Joanna Laurson-Doube, Amy M.L. Quek, Kevin Tan, Tianrong Yeo, Mya Mya Aye Seinn, Ohnmar Ohnmar, Riwanti Estiasari, Norazieda Yassin, Fu Liong Hiew, Paul M. Pasco, Nghia T.T. Hoang, Saysavath Keosodsay, Sasitorn Siritho, Metha Apiwattanakul, Sina Ros, Brigido Simao Dias de Deus, Rabani Remli, Suhailah Abdullah, Su-Yin Lim
Despite the global availability of multiple sclerosis (MS) treatments, accessing and financing them in Southeast Asia (SEA) remains a challenge. This descriptive survey-based study aimed to describe the current state of MS treatment access and local access dynamics within this region. The survey questionnaire, comprising of 15 closed-ended and five open-ended questions, was developed by three neurologists
-
Association between clinical characteristics, acute steroid treatment and oligoclonal bands result in multiple sclerosis: A retrospective study Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-16 Assaf Tolkovsky, Keshet Pardo, Mark Hellmann, Itay Lotan, Eitan Auriel, Adi Wilf-Yarkoni
Detection of oligoclonal bands (OCBs) in the cerebrospinal fluid (CSF) is important for diagnosis of multiple sclerosis (MS). Previous studies reported that treatment with intravenous methylprednisolone (IVMP) before lumber puncture (LP) could suppress OCBs production. The aim of this study was to assess whether IVMP initiation prior to CSF collection affects OCBs results in patients with an acute
-
Burden of treatment and quality of life in relapsing remitting multiple sclerosis patients under early high efficacy therapy in Argentina: Data from the Argentinean registry Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-16 Juan I. Rojas, Edgar Carnero Contentti, Ricardo Alonso, Dario Tavolini, Marcos Burgos, Belén Federico, Liliana Patrucco, Edgardo Cristiano
The objective of this study was to describe and compare the burden of treatment (BOT) and the quality of life (QoL) in early high efficacy therapy (HET) vs. escalation therapy in relapsing remitting multiple sclerosis (RRMS) patients included in RelevarEM, the Argentinean registry of MS (RelevarEM, NCT 03,375,177). cross sectional study conducted between September and December 2022. Participating patients
-
A study of referral bias in NMOSD and MOGAD cohorts Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-14 Miguel Leal Rato, Bo Chen, Anna Francis, Silvia Messina, Madalina Miron, Yvonne Sharawakanda, Eoin O'Sullivan, Sarah Cooper, Leonora Fisniku, Christopher Halfpenny, Roswell Martin, Jeremy Hobart, Waqar Rashid, Cheryl Hemingway, Victoria Williams, Yael Hacohen, Ruth Dobson, Sithara Ramdas, Maria Isabel Leite, Jacqueline Palace, Ruth Geraldes
Neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) are rare disorders often seen in highly specialized services or tertiary centres. We aimed to assess if cohort characteristics depend on the origin of the referral catchment areas serviced by our centre (i.e. local, regional or national). Retrospective cohort study using a national
-
Association of oral disease-modifying agents and their adherence trajectories with annual relapses in multiple sclerosis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-12 Jagadeswara Rao Earla, Jieni Li, George J. Hutton, John P. Bentley, Rajender R. Aparasu
Real-world effectiveness can vary across oral disease-modifying agents (DMAs) and their adherence trajectories in patients with multiple sclerosis (MS). However, previous studies have not considered longitudinal adherence patterns while evaluating oral DMAs. This study aimed to evaluate the association of oral DMAs and their adherence trajectories with annualized relapse rate (ARR) in patients with
-
Neonatal outcomes in women with Multiple Sclerosis – Influence of disease activity: A Danish nationwide cohort study Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-11 Mette Louise Andersen, Line Riis Jølving, Maria Iachina, Pavithra Laxsen Anru, Egon Stenager, Torben Knudsen, Bente Mertz Nørgård
Maternal Multiple Sclerosis (MS) has been associated with an increased risk of adverse birth outcomes. We hypothesized that active disease during conception and pregnancy plays an important role in this context, which this study aims to address. We used the Danish registers to conduct a nationwide cohort study. Information on maternal disease activity during pregnancy was retrieved using proxies from
-
Enlarged choroid plexus in relapsing-remitting multiple sclerosis may lead to brain structural changes through the glymphatic impairment Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-11 Yan Xie, Hongquan Zhu, Yihao Yao, Chengxia Liu, Shaolong Wu, Yan Zhang, Wenzhen Zhu
To investigate the potential link among choroid plexus (CP) volume, glymphatic clearance and brain structural change in relapsing-remitting multiple sclerosis (RRMS) patients. Sixty-five RRMS patients and 48 healthy controls (HC) underwent MRI examination. The diffusion tensor image analysis along the perivascular space (DTI-ALPS) was calculated to reflect glymphatic system function. The brain structure
-
Olfactory threshold as a biomarker of long-term relapse activity in multiple sclerosis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-11 Klaus Berek, Harald Hegen, Michael Auer, Robert Barket, Franziska Di Pauli, Jakob Hocher, Nik Krajnc, Anne Zinganell, Florian Deisenhammer, Thomas Berger, Gabriel Bsteh
Olfactory threshold (OT) is a marker of short-term inflammatory activity in multiple sclerosis (MS). To investigate whether OT predicts long-term MS clinical disease course. This was a 6-year prospective longitudinal study on MS patients at the MS clinic Innsbruck. Clinical visits assessing the occurrence of relapses, Expanded Disability Status Scale (EDSS) scores, and disease-modifying treatment (DMT)
-
Multiple Sclerosis Multidisciplinary Care: A National Survey and Lessons for the Global Community Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-11 Liesbeth Van Hijfte, Melissa Cambron, Brigitte Capron, Bernard Dachy, Danny Decoo, Dominique Dive, Bénédicte Dubois, Souraya El Sankari, Frederic London, Gaetano Perrotta, Veronica Popescu, Vincent Van Pesch, Bart Van Wijmeersch, Barbara Willekens, Guy Laureys, Belgian Study Group for Multiple Sclerosis (BSGMS)
Access to, standardization and reimbursement of multidisciplinary care for people with MS (PwMS) is lacking in many countries. Therefore, this study aims to describe the current multidisciplinary care for people with MS (PwMS) in Belgium and identify benefits, needs and future perspectives A survey for PwMS questioned various aspects of MS and viewpoints on care. For MS nurses (MSN) and neurologists
-
Do proprioceptive neuromuscular facilitation techniques improve respiratory parameters and swallowing in people with multiple sclerosis: A randomized-controlled study Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-11 Julide Kesebir, Rabia Gokcen Gozubatık Celik, Yonca Zenginler, Burcu Yüksel, Aysu Sen, Buket Akinci
This study aims to investigate the effects of Proprioceptive Neuromuscular Facilitation (PNF) techniques on respiratory parameters, swallowing, functional capacity, fatigue, and quality of life in people with Multiple Sclerosis (PwMS). Thirty-four PwMS were included and randomized into the PNF Group (mean age: 43.23±10.55/years) or Control Group (mean age:38.47±8.18/years). In the PNF group, head-neck
-
Cerebrospinal fluid eosinophils in pediatric myelin oligodendrocyte glycoprotein antibody-associated disease Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-09 Alexandra B. Kornbluh, Victor M. Campano, Claire Har, Pallavi Dwivedi, William Suslovic, Leigh Sepeta, Ilana Kahn
Eosinophils in cerebrospinal fluid (CSF) are an uncommon finding most often associated with parasitic infections, but have also been described in some neuroinflammatory disorders. Eosinophilic infiltration is not thought to be a typical feature of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). We aim to describe the rate of CSF eosinophil positivity in a cohort of pediatric
-
Intrathecal B cell activation and memory impairment in multiple sclerosis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-08 Lorenzo Gaetani, Nicola Salvadori, Giovanni Brachelente, Silvia Sperandei, Elena Di Sabatino, Andrea Fiacca, Andrea Mancini, Alfredo Villa, Nicola De Stefano, Lucilla Parnetti, Massimiliano Di Filippo
Cognitive impairment (CI) is a common and disabling feature of people with multiple sclerosis (pwMS), but its underlying mechanisms are heterogenous and not fully understood. A role of infiltrating immune cells in the meninges and brain parenchyma has been hypothesized. This study aimed to explore the hypothesis that intrathecal B cells might influence cognitive performance in pwMS. A retrospective
-
Breakthrough COVID-19 in people with multiple sclerosis on disease modifying treatments: Is it still a severe disease? Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-08 Paolo Immovilli, Irene Schiavetti, Alessandro Franceschini, Paola De Mitri, Lorenza Gelati, Eugenia Rota, Donata Guidetti
Disease modifying treatments (DMTs) for multiple sclerosis (MS) are effective in preventing both relapses and disability progression. Highly effective treatments (HETs) are more effective than platform therapy in preventing confirmed disability progression (CDP), when used early. Infections may complicate HETs administration, and their prevention through vaccination is crucial in order to assure the
-
Asthma and chronic obstructive pulmonary disease (COPD) in people with multiple sclerosis: A systematic review and meta-analysis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-08 Hamed Ghoshouni, Nazanin Rafiei, Mohammad Yazdan Panah, Danial Dehghani Firouzabadi, Farhad Mahmoudi, Mona Asghariahmadabad, Vahid Shaygannejad, Omid Mirmosayyeb
Studies have found that multiple sclerosis (MS) has an impact on the initiation or the course of asthma and chronic obstructive pulmonary disease (COPD). This review amied to investigate the prevalence and odds of asthma and COPD among people with MS (pwMS). PubMed, Embase, Scopus, and Web of Science were systemically searched from inception to May 2023. R version 4.3.2 and random-effect model were
-
OCT-Angiography in AQP4-positive NMOSD: finding subclinical disease using a new tool Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-08 E. Ann Yeh, Gavin Giovannoni, Chris Hawkes, Robert C. Sergott, Michael Levy, Jeannette Lechner-Scott
-
Lymphocytic infiltration in multiple sclerosis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-08 Ranjeet Singh Mahla
-
Impact of rituximab treatment regime on time to relapse in aquaporin-4 antibody positive neuromyelitis optica spectrum disorder Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-07 Moneeb Nasir, Luke Hone, Emma Tallantyre, Patricia Kelly, Maria Isabel Leite, Neil Robertson, Jonathan Bestwick, Saif Huda, Jacqueline Palace, Ruth Dobson
Aquaporin-4 (AQP4) antibody associated neuromyelitis optica (NMOSD) requires long-term immunosuppression. Rituximab is increasingly used worldwide, however the optimal regime is not established. We retrospectively examined different rituximab regimens in AQP4-NMOSD. Standard monotherapy (SM; 6 monthly infusions), SM plus oral steroids (SM+), extended interval dosing (EID; guided by CD19 repopulation)
-
Exclusion of alternative diagnoses: A component of the 2023 MOGAD criteria that belongs at the forefront, not in the background Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-07 A, d, r, i, a, n, , B, u, d, h, r, a, m
-
Metronomic radiological surveillance in clinically stable MS patients on anti CD20 immunotherapy is redundant Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-06 J, a, g, a, n, n, a, d, h, a, , A, v, a, s, a, r, a, l, a
-
What is the importance of family planning in multiple sclerosis? A study in the Brazilian population Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-05 Elisa Matias Vieira de Melo, Maria Fernanda Mendes, Guilherme Sciascia do Olival
Multiple Sclerosis is a disease of young females at a reproductive age. discuss family planning in the context of providing care for women with MS patients with Multiple Sclerosis, female, aged between 18 and 45 years, from 01/Nov/2021 to 16/Jan/2022 participated, all of whom answered a questionnaire made available on the Google forms platform. A total of 233 responses were validated. Most patients
-
Characteristics and predictors of sexual dysfunction in men with multiple sclerosis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-05 Ivan Adamec, Tomislav Sambolić, Mihovil Santini, Antea Karić, Anamari Junaković, Barbara Barun, Tereza Gabelić, Luka Crnošija, Magdalena Krbot Skorić, Mario Habek
To validate and culturally adapt the Sexual Health Inventory for Men (IIEF-5) and the Premature Ejaculation Diagnostic Tool (PEDT), to compare the frequency and severity of erectile dysfunction (ED) and premature ejaculation (PE) in male individuals with MS (mwMS) in comparison with healthy controls (HC) and to investigate predictors of the severity of ED and PE in mwMS. 216 consecutive mwMS and 37
-
Prognostic factors of tumefactive demyelinating lesions and differential features for multiple sclerosis in etiology Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-05 Furkan Saridas, Gizem Mesut, Ceren Yayla Ceylan, Rifat Ozpar, Mine Ozsen, Emine Rabia Koc, Sahsine Tolunay, Bahattin Hakyemez, Omer Faruk Turan
Many different pathologies may underlie tumefactive demyelinating lesions. Identifying clinical and radiologic distinguishing features before pathologic examination is essential for diagnosis and treatment. In this study, we aimed to determine the clinical and radiologic features affecting the etiology and disease course of patients with tumefactive lesions (TDL). We included 35 clinicoradiologically
-
Feasibility and tolerability of portable, low-field brain MRI for patients with multiple sclerosis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-04 Andrew Siyoon Ham, Cristina Trápaga Hacker, Jennifer Guo, Annabel Sorby-Adams, W. Taylor Kimberly, Farrah J. Mateen
-
Headache disorders in multiple sclerosis: Is there an association? A systematic review and meta-analysis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-03 Panagiotis Gklinos, Dimos-Dimitrios Mitsikostas
To look for any potential association of headache disorders with multiple sclerosis (MS). The prevalence of headache disorders has been found to be increased in people with MS (pwMS), however, an association has not been established. Existing studies have provided conflicting results mostly because of methodological differences. PubMed, Embase and Scopus were searched to identify eligible studies.
-
Seizures in inflammatory demyelinating disorders of the central nervous system Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-03 Özdem Ertürk Çetin, İpek Güngör Doğan, Ümit Zanapalioğlu, Feyzullah Yadi, Damla Çetinkaya Tezer, Serkan Demir
Multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) may be associated with acute symptomatic seizures and chronic epilepsy as well. The clinical features of the seizures and/or accompanying epilepsy seen in each disease group may vary. In this study, we aimed to contribute to the existing literature by
-
Under & Over: A randomised controlled study to develop an upper limb rehabilitation tool for people with Multiple Sclerosis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-01 Alison Thomson, Andrea Stennett, Canan Metin, Jonathan Bestwick, Gavin Giovannoni, Ruth Dobson
Impairment of upper limb function is common in Multiple Sclerosis (MS). Rehabilitation remains a key strategy to manage symptoms and improve quality of life. The Under & Over study assessed the effectiveness of a rehabilitation programme in people with advanced MS. To determine if repeated use of Under & Over can improve upper limb function for people with MS. One hundred and six ( = 106) people with
-
Comparison of patient-reported outcomes of physical activity and accelerometry in people with multiple sclerosis and ambulatory impairment: A cross-sectional study Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-01 Andreas Wanitschek, Barbara Seebacher, Andreas Muehlbacher, Christian Brenneis, Rainer Ehling
Accelerometers and patient-reported outcomes (PRO) are used to assess physical activity (PA) in people with multiple sclerosis (pwMS). So far it is unknown, however, whether these assessments represent mobility limitations in pwMS with mild and moderate to severe disability alike. The primary aim of the study was to assess the correlation between accelerometry and International Physical Activity Questionnaire