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Plasma neurofilament light chain is increased in Niemann-Pick Type C but glial fibrillary acidic protein remains normal Acta Neuropsychiatr. (IF 3.8) Pub Date : 2024-03-27 Dhamidhu Eratne, Courtney Lewis, Wendy Kelso, Samantha Loi, Wei-Hsuan Michelle Chiu, Kaj Blennow, Henrik Zetterberg, Alexander F Santillo, Dennis Velakoulis, Mark Walterfang
OBJECTIVE: Niemann-Pick Type C (NPC) is a genetic neurodegenerative lysosomal storage disorder commonly associated with psychiatric symptoms and delays to accurate diagnosis and treatment. This study investigated biomarker levels and diagnostic utility of plasma neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in NPC compared to healthy controls. METHODS: Patients with NPC
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Interplay of combat deployment harassment, testosterone concentrations, and post-deployment suicide risk in male veterans Acta Neuropsychiatr. (IF 3.8) Pub Date : 2024-03-26 Leo Sher, Linda M. Bierer, Janine Flory, Iouri Makotkine, Rachel Yehuda
Objective: Many combat veterans exhibit suicidal ideation and behavior, but the relationships among experiences occurring during combat deployment and suicidality are still not fully understood. In this study, we tested the hypothesis that harassment during a combat deployment is associated with post-deployment suicidality and testosterone function. Methods: Male combat veterans who made post-deployment
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On hallucinations and memory: the relationship between hallucinations and autobiographical overgenerality in Alzheimer’s Disease Acta Neuropsychiatr. (IF 3.8) Pub Date : 2024-02-19 Mohamad El Haj, Frank Larøi
Objectives: Alzheimer’s disease (AD) has been associated with autobiographical overgenerality (i.e. a tendency of patients to retrieve general rather than specific personal memories). AD has also been associated with hallucinations. We investigated the relationship between autobiographical overgenerality and hallucinations in AD.Methods: We invited 28 patients with mild AD to retrieve autobiographical
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White matter tract alterations in schizophrenia identified by DTI-based probabilistic tractography: a multisite harmonisation study Acta Neuropsychiatr. (IF 3.8) Pub Date : 2024-02-13 Young Tak Jo, Sung Woo Joo, Woohyeok Choi, Soohyun Joe, Jungsun Lee
Introduction: It has been suggested that schizophrenia involves dysconnectivity between functional brain regions and also the white matter structural disorganisation. Thus, diffusion tensor imaging (DTI) has widely been used for studying schizophrenia. However, most previous studies have used the region of interest (ROI) based approach. We, therefore, performed the probabilistic tractography method
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Effects of electroconvulsive therapy on cortical thickness in depression: a systematic review Acta Neuropsychiatr. (IF 3.8) Pub Date : 2024-02-12 Tommaso Toffanin, Giulia Cattarinussi, Niccolò Ghiotto, Marialaura Lussignoli, Chiara Pavan, Luca Pieri, Sami Schiff, Francesco Finatti, Francesca Romagnolo, Federica Folesani, Maria Giulia Nanni, Rosangela Caruso, Luigi Zerbinati, Martino Belvederi Murri, Maria Ferrara, Giorgio Pigato, Luigi Grassi, Fabio Sambataro
Objective: Electroconvulsive therapy (ECT) is one of the most studied and validated available treatments for severe or treatment-resistant depression. However, little is known about the neural mechanisms underlying ECT. This systematic review aims to critically review all structural magnetic resonance imaging studies investigating longitudinal cortical thickness (CT) changes after ECT in patients with
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The association between common mental disorders and tuberculosis: a case–control study from Guinea-Bissau Acta Neuropsychiatr. (IF 3.8) Pub Date : 2024-02-08 Lena Larson, Grethe Lemvik, Frauke Rudolf, Victor Francisco Gomes, Andreas Schröder, Christian Wejse
Objective: The aim of the study was to explore the association between tuberculosis (TB) and common mental disorders (CMD), in an area with high prevalence of TB.Methods: We performed a case–control study of TB patients and unmatched healthy controls, from a demographic surveillance site in Guinea-Bissau. Screening for CMD was performed once for controls and at inclusion and follow-up for TB patients
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Aggressive behaviours associated with MDMA and psychedelics: a narrative review Acta Neuropsychiatr. (IF 3.8) Pub Date : 2024-02-08 Negar Sayrafizadeh, Nicole Ledwos, M. Ishrat Husain, David J. Castle
Objective: Monoamine neurotransmitters play a role in aggression, especially when altered by illicit substances. However, some literature suggests that not all illicit substances may lead to aggression, notably psychedelics. This narrative review investigates the associations between serotonergic psychedelics and MDMA on aggressive behaviour.Methods: PubMed and PsycINFO were searched for original,
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Cannabis-induced psychotic disorder with onset during withdrawal: a brief report of emerging evidence Acta Neuropsychiatr. (IF 3.8) Pub Date : 2024-01-11 Johan Cohen, Hugues Petitjean, M. Belen Blasco, Romina Mizrahi
Objectives: The link between cannabis use and psychotic symptoms or disorders is well known. However, the relation between cannabis withdrawal and psychotic symptoms is less studied.Methods: To our knowledge, this is the first publication of an observational systematic report of cannabis-induced psychotic disorder with onset during withdrawal. Here, we review patients presenting to a major emergency
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Bradykinin actions in the central nervous system: historical overview and psychiatric implications Acta Neuropsychiatr. (IF 3.8) Pub Date : 2024-01-05 Frederico Guilherme Graeff, Sâmia Joca, Helio Zangrossi
Bradykinin (BK), a well-studied mediator of physiological and pathological processes in the peripheral system, has garnered less attention regarding its function in the central nervous system, particularly in behavioural regulation. This review delves into the historical progression of research focused on the behavioural effects of BK and other drugs that act via similar mechanisms to provide new insights
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Dysfunction of circulating endothelial progenitor cells in major depressive disorder Acta Neuropsychiatr. (IF 3.8) Pub Date : 2024-01-05 Ying-Jay Liou, Mu-Hong Chen, Ju-Wei Hsu, Kai-Lin Huang, Po-Hsun Huang, Ya-Mei Bai
Objectives: Despite mounting evidence demonstrates circulating endothelial progenitor cells (cEPCs) quantitative changes in depression, no study has investigated cEPC functions in major depressive disorder (MDD). We investigated the role of cEPC adhesive and apoptotic functions in MDD.Methods: We recruited 68 patients with MDD and 56 healthy controls (HCs). The depression symptoms, anxiety, psychosomatic
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Social cognition, emotion regulation and social competence in classical galactosemia patients without intellectual disability Acta Neuropsychiatr. (IF 3.8) Pub Date : 2024-01-05 Merel E. Hermans, Gert J. Geurtsen, Carla E.M. Hollak, Mirian C.H. Janssen, Janneke G. Langendonk, Valerie L.V. Merckelbach, Esmee Oussoren, Kim J. Oostrom, Annet M. Bosch
Objective: Classical galactosemia (CG) is an inborn error of galactose metabolism. Many CG patients suffer from long-term complications including poor cognitive functioning. There are indications of social dysfunction but limited evidence in the literature. Therefore, this study aims to improve our understanding of social competence in CG by investigating social cognition, neurocognition and emotion
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Cytokines in hepatitis C-infected patients with or without opioid maintenance therapy Acta Neuropsychiatr. (IF 3.8) Pub Date : 2024-01-04 Kristin Nygaard-Odeh, Hedda Soloy-Nilsen, Magnhild Gangsoy Kristiansen, Ole Lars Brekke, Tom Eirik Mollnes, Michael Berk, Jorgen G. Bramness, Terje Oiesvold
Objective: Both chronic hepatitis C virus (HCV) infection and opioids cause altered blood levels of cytokines. Previous studies have investigated levels of selected groups of cytokines in patients on opioid maintenance treatment. Little is known about the levels of multiple cytokines in patients with chronic HCV infection on opioid maintenance treatment. Our aim was to investigate the cytokine profile
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Investigation of the effects of oxidative stress, inflammation on the pathway of tryptophan/kynurenine in OCD Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-11-28 Elif Delen, Cem Ismail Kucukali, Zerrin Karaaslan, Hande Yuceer, Seyma Punar, Mehmet Tolgahan Hakan, Ilhan Yaylim, Elif Ozkok
Objectives: Recent studies have shown that the distribution of the tryptophan/kynurenine pathway (KP) plays a role in the development of obsessive-compulsive disorder (OCD). We aimed to reveal the relationship between CYP1A1 rs464903 and aryl hydrocarbon receptor (AhR) rs10249788 associated with the KP and interferon gamma (IFN γ) and oxidative stress in OCD.Methods: In our study, the serum and DNAs
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The influence of peer non-suicidal self-harm on young adults’ urges to self-harm: experimental study Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-11-28 Alexandra Pitman, Millie Lowther, Alexandra Pike, Jessica Davies, Angharad de Cates, Joshua E. J. Buckman, Oliver Robinson
Objective: To test the hypothesis that exposure to peer self-harm induces adolescents’ urges to self-harm and that this is influenced by individual suggestibility.Methods: We recruited 97 UK-based adults aged 18–25 years with a recent history of self-harm, measuring baseline suggestibility (Resistance to Peer Influence; RPI) and perceived ability to control urges to self-harm (using an adapted item
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Interplay between endocannabinoid and endovanilloid mechanisms in fear conditioning Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-11-20 Rayssa C. Briânis, Julia P. Andreotti, Fabrício A. Moreira, Lia P. Iglesias
Objective: The transient receptor potential cation channel, subfamily V (vanilloid), member 1 (TRPV1) mediates pain perception to thermal and chemical stimuli in peripheral neurons. The cannabinoid receptor type 1 (CB1), on the other hand, promotes analgesia in both the periphery and the brain. TRPV1 and CB1 have also been implicated in learned fear, which involves the association of a previously neutral
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Effects of cannabidiol on reward contextual memories induced by cocaine in male and female mice Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-11-16 Rayssa C. Briânis, Lia P. Iglesias, Lucas G. Bedeschi, Fabrício A. Moreira
Objective: Preclinical studies suggest that cannabidiol (CBD), a non-intoxicating phytocannabinoid, may reduce addiction-related behaviours for various drug classes in rodents, including ethanol, opiates, and psychostimulants. CBD modulates contextual memories and responses to reward stimuli. Nonetheless, research on the impact of CBD on cocaine addiction-like behaviors is limited and requires further
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Running from depression: the antidepressant-like potential of prenatal and pre-pubertal exercise in adolescent FSL rats exposed to an early-life stressor Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-11-16 Ashleigh J. Whitney, Zander Lindeque, Ruan Kruger, Stephan F. Steyn
Objective: We aimed to answer the questions of whether early-life (perinatal and/or juvenile) exercise can induce antidepressant-like effects in a validated rodent model of depression, and whether such early-life intervention could prevent or reverse the adverse effects of early-life stress in their offspring.Methods: Male and female Flinders sensitive line rats born to a dam that exercised during
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Navigating the complexity of COVID-19: a multifaceted examination. Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-11-10 Gregers Wegener
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Occurrence of metabolic syndrome in untreated bipolar disorders: a cross-sectional study Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-10-16 Qianli Liu, Lan Wang, Fengya Zhen, Cuixia An
Objective: This cross-sectional study aimed to observe the occurrence of metabolic syndrome in untreated individuals with bipolar disorders.Methods: A total of 125 untreated individuals with bipolar disorders were collected as the study group, and 201 cases from the health examination centre of our hospital were selected as the control group. The participants enrolled were assessed for general demographic
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Blood–brain barrier permeability and electroconvulsive therapy: a systematic review Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-10-16 Christoffer C. Lundsgaard, Krzysztof Gbyl, Poul Videbech
Objective: The cause of cognitive side effects after electroconvulsive therapy (ECT) is largely unknown. Alterations in the blood–brain barrier (BBB) have been considered in several recent ECT studies. We therefore found it worthwhile to perform a systematic review of the literature to examine if electrically induced seizures affect the permeability of the BBB.Methods: PubMed/MEDLINE and Embase were
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The burden of major depressive disorder in the Middle East and North Africa region, 1990–2019 Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-09-11 Saeid Safiri, Seyed Ehsan Mousavi, Seyed Aria Nejadghaderi, Maryam Noori, Mark J. M. Sullman, Ali-Asghar Kolahi, Reza Shekarriz-Foumani
Background: Major depressive disorder (MDD) is one of the leading causes of disability. We aimed to report the MDD-attributable prevalence, incidence and years lived with disability (YLDs) in the Middle East and North Africa (MENA) region from 1990 to 2019 by age, sex and socio-demographic index (SDI).Methods: Publicly available data on the burden of MDD were retrieved from the Global Burden of Disease
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Role of T and B lymphocyte cannabinoid type 1 and 2 receptors in major depression and suicidal behaviours Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-09-08 Michael Maes, Muanpetch Rachayon, Ketsupar Jirakran, Atapol Sughondhabirom, Abbas F. Almulla, Pimpayao Sodsai
Early flow cytometry studies revealed T cell activation in major depressive disorder (MDD). MDD is characterised by activation of the immune-inflammatory response system (IRS) and the compensatory immunoregulatory system (CIRS), including deficits in T regulatory (Treg) cells. This study examines the number of cannabinoid type 1 (CB1) and type 2 (CB2) receptor-bearing T/B lymphocytes in MDD, and the
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Psychiatric sequelae after SARS-Cov-2 infection: trajectory, predictors and associations in a longitudinal Australian cohort Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-09-08 Seetal Dodd, Mohammedreza Mohebbi, Josie O’Donohue, Gail Matthews, David R. Darley, Michael Berk
A relationship between SARS-CoV-2 infection and psychiatric symptoms has been identified but is still being fully investigated. Neuropsychiatric sequalae have been reported for several infectious agents and are not unexpected for SARS-CoV-2 infection. This study follows for 12 months a sample (N = 144) of people who have had a confirmed infection of SARS-CoV-2. Medical and neuropsychiatric data and
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Genetic risk scores associated with temperament clusters in Finnish depression patients Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-09-04 Simo-Pekko Salminen, Anssi Solismaa, Leo-Pekka Lyytikäinen, Vesa Paavonen, Nina Mononen, Terho Lehtimäki, Esa Leinonen, Olli Kampman
Objective: Cloninger’s temperament dimensions have been studied widely in relation to genetics. In this study, we examined Cloninger’s temperament dimensions grouped with cluster analyses and their association with single nucleotide polymorphisms (SNPs). This study included 212 genotyped Finnish patients from the Ostrobothnia Depression Study.Methods: The temperament clusters were analysed at baseline
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Serum levels of folate, vitamin B6, and vitamin B12 are associated with cognitive impairments in depression patients Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-08-29 Lei Zhao, Lili Guan, Jinyan Sun, Xiaoming Li
Introduction: Depression is a common mental disorder that endangers physical and mental health. In our study, we aimed to explore whether B vitamins are associated with depression and cognitive dysfunction.Methods: We enrolled a total of 220 patients with depression and selected 100 controls at the same time. We determined depression and cognitive impairment by assessments. We recorded the basic parameters
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Rumination in bipolar disorder associated with brain network and behavioural measures of inhibitory executive control Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-08-25 Tina Chou, Darin D. Dougherty, Andrew A. Nierenberg, Sharmin Ghaznavi
Objective: Rumination is a passive form of negative self-focused cognition that predicts depressive episodes for individuals with bipolar disorder (BD). Individuals with BD also have impaired inhibitory executive control; rumination in BD may therefore reflect executive dysfunction. We investigated the relationship between a neural measure of executive functioning (functional connectivity between the
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Structural impairment in superficial and deep white matter in schizophrenia Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-08-25 Sung Woo Joo, Young Tak Jo, Soojin Ahn, Young Jae Choi, Woohyeok Choi, Sang Kyoung Kim, Soohyun Joe, Jungsun Lee
Objective: Although disconnectivity among brain regions has been one of the main hypotheses for schizophrenia, the superficial white matter (SWM) has received less attention in schizophrenia research than the deep white matter (DWM) owing to the challenge of consistent reconstruction across subjects.Methods: We obtained the diffusion magnetic resonance imaging (dMRI) data of 223 healthy controls and
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Lexical stability of psychiatric clinical notes from electronic health records over a decade Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-08-25 Lasse Hansen, Kenneth Enevoldsen, Martin Bernstorff, Erik Perfalk, Andreas A. Danielsen, Kristoffer L. Nielbo, Søren D. Østergaard
Objective: Natural language processing (NLP) methods hold promise for improving clinical prediction by utilising information otherwise hidden in the clinical notes of electronic health records. However, clinical practice – as well as the systems and databases in which clinical notes are recorded and stored – change over time. As a consequence, the content of clinical notes may also change over time
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Distributed genetic effects of the corpus callosum subregions suggest links to neuropsychiatric disorders and related traits Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-08-24 Megan L. Campbell, Shareefa Dalvie, Alexey Shadrin, Dennis van der Meer, Kevin O’Connell, Oleksander Frei, Ole A. Andreassen, Dan J. Stein, Jaroslav Rokicki
Background: The corpus callosum (CC) is a brain structure with a high heritability and potential role in psychiatric disorders. However, the genetic architecture of the CC and the genetic link with psychiatric disorders remain largely unclear. We investigated the genetic architectures of the volume of the CC and its subregions and the genetic overlap with psychiatric disorders.Methods: We applied multivariate
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Midline brain structures in adult Niemann-Pick type C disease: a cross-sectional study Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-08-24 Mark Walterfang, Tsutomu Takahashi, Maria A. Di Biase, Vanessa L. Cropley, Daiki Sasabayashi, Michio Suzuki, Dennis Velakoulis, Christos Pantelis
Objective: A range of neuropathological changes occur in the brains of individuals with adult Niemann-Pick type C disease (NPC), a recessive disorder of cholesterol trafficking that results in accumulation of cholesterol and gangliosides in lysosomes, particularly in neurons. One of the most significant regions of grey matter loss occurs in the thalami, which abut the midline. What is not known is
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Cannabidiol negatively modulates adenosine A2A receptor functioning in living cells Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-08-22 Nuria Sánchez-Fernández, Laura Gómez-Acero, Laura I. Sarasola, Josep Argerich, Andy Chevigné, Kenneth A. Jacobson, Francisco Ciruela, Víctor Fernández-Dueñas, Ester Aso
Objectives: Cannabidiol (CBD) is a phytocannabinoid with great potential in clinical applications. The mechanism(s) of action of CBD require further investigation. Previous studies suggested that adenosine A2A receptors (A2ARs) could play a role in CBD-induced effects. Here, we evaluated the ability of CBD to modify the function of A2AR.Methods: We used HEK-293T cells transfected with the cDNA encoding
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Decreased beta 1 (12–15 Hertz) power modulates the transfer of suicidal ideation to suicide in major depressive disorder Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-08-22 Chenguang Jiang, Zixuan Huang, Zhenhe Zhou, Limin Chen, Hongliang Zhou
Background: Suicide prevention for major depressive disorder (MDD) is a worldwide challenge, especially for suicide attempt (SA). Viewing suicide as a state rather than a lifetime event provided new perspectives on suicide research.Objective: This study aimed to verify and complement SAs biomarkers of MDD with a recent SA sample.Methods: This study included 189 participants (60 healthy controls; 47
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Pharmacogenetics of angiotensin modulators according to APOE-ϵ4 alleles and the ACE insertion/deletion polymorphism in Alzheimer’s disease Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-08-22 Fabricio Ferreira de Oliveira, Sandro Soares de Almeida, Elizabeth Suchi Chen, Marilia Cardoso Smith, Paulo Henrique Ferreira Bertolucci
Objective: In Alzheimer’s disease (AD), angiotensin II receptor blockers (ARBs) could reduce cerebrovascular dysfunction, while angiotensin-converting enzyme inhibitors (ACEis) might increase brain amyloid-β by suppressing effects of the angiotensin-converting enzyme 1, an amyloid-β-degrading enzyme. However, ACEis could benefit patients with AD by reducing the amyloidogenic processing of the amyloid
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As a new challenger approaches, how will modern psychiatry cope with 'shifting realities'? Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-08-18 John O'Neill,Bahareh Nakisa,Harris Eyre,Ipsit V Vahia,Stephen M Schueller,Marina Tolou-Shams,Robert M Lundin
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Dual administration of lipopolysaccharide induces behavioural changes in rats relevant to psychotic disorders Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-08-18 Yi-Ran Zheng, Maximilian Tufvesson-Alm, Ada Trepci, Sophie Imbeault, Xue-Qi Li, Lilly Schwieler, Göran Engberg, Sophie Erhardt
Objective: We previously reported that dual injections of lipopolysaccharide (LPS) in mice constitute a valuable tool for investigating the contribution of inflammation to psychotic disorders. The present study investigated how immune activation affects the kynurenine pathway and rat behaviour of relevance for psychotic disorders.Methods: Male Sprague Dawley rats were treated with either dual injections
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Genetically predisposed and resilient animal models of depression reveal divergent responses to early-life adversity Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-08-18 Ashleigh J Whitney, Zander Lindeque, Ruan Kruger, Stephan F Steyn
Objective: Early-life adversity (ELA) is one of the strongest predictors of childhood depression that may be exacerbated by a genetic predisposition to develop depression. We therefore investigated the bio-behavioural effects of an early-life stressor in an accepted rodent model of depression.Methods: The Flinders sensitive line (FSL) and resistant line (FRL) rats were subjected to an early-life stressor
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Preliminary evaluation of a smartphone application (DelApp) for identification of delirium in sub-Saharan Africa Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-06-22 Stella-Maria Paddick, Editruda Gamassa, Nuru Mwaluwinga, Grace Lewis, Ashanti Duinmaijer, Sarah Urasa, Laura Tucker, Elizabeta Blagoja Mukaetova-Ladinska, Glynis Cosker, Marieke Dekker, Aloyce Kisoli, Jane Cletus, Caroline Lissu, Catherine Dotchin, William K. Gray, Richard Walker
Objective: In sub-Saharan Africa, there are no validated screening tools for delirium in older adults, despite the known vulnerability of older people to delirium and the associated adverse outcomes. This study aimed to assess the effectiveness of a brief smartphone-based assessment of arousal and attention (DelApp) in the identification of delirium amongst older adults admitted to the medical department
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Predictors of within-individual variability in cognitive performance in schizophrenia in a South African case–control study Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-06-21 Olivia Wootton, Shareefa Dalvie, Rae MacGinty, Linda Ngqengelele, Ezra S. Susser, Ruben C. Gur, Dan J. Stein
Introduction: Cognitive dysfunction in schizophrenia may be assessed by measuring within-individual variability (WIV) in performance across a range of cognitive tests. Previous studies have found increased WIV in people with schizophrenia, but no studies have been conducted in low- to middle-income countries where the different sociocultural context may affect WIV. We sought to address this gap by
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Extracellular vesicle microRNA-mediated transcriptional regulation may contribute to dementia with Lewy bodies molecular pathology Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-06-21 Fatma Busra Isik, Helen Miranda Knight, Anto P. Rajkumar
Objective: Dementia with Lewy bodies (DLB) is the second most common dementia. Advancing our limited understanding of its molecular pathogenesis is essential for identifying novel biomarkers and therapeutic targets for DLB. DLB is an α-synucleinopathy, and small extracellular vesicles (SEV) from people with DLB can transmit α-synuclein oligomerisation between cells. Post-mortem DLB brains and serum
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Time to transition from paediatric to adolescent bipolar disorder. Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-05-16 Gin S Malhi,Maedeh Jadidi,Erica Bell
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Increased markers of inflammation after cannabis cessation and their association with psychotic symptoms Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-04-28 Bruno Romeo, Valentine Lestra, Catherine Martelli, Ammar Amirouche, Amine Benyamina, Nora Hamdani
Introduction: A dysbalance of the immune system in psychotic disorders has been well investigated. However, despite a higher prevalence of cannabis (THC) consumption in patients with psychosis, few studies have investigated the impact of this use on inflammatory markers.Methods: One hundred and two inpatients were included in this retrospective study. Leukocytic formula, hsCRP, fibrinogen levels and
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Cerebrospinal fluid neurofilament light predicts longitudinal diagnostic change in patients with psychiatric and neurodegenerative disorders Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-04-28 Matthew J. Y. Kang, Dhamidhu Eratne, Hannah Dobson, Charles B. Malpas, Michael Keem, Courtney Lewis, Jasleen Grewal, Vivian Tsoukra, Christa Dang, Ramon Mocellin, Tomas Kalincik, Alexander F. Santillo, Henrik Zetterberg, Kaj Blennow, Christiane Stehmann, Shiji Varghese, Qiao-Xin Li, Colin L. Masters, Steven Collins, Samuel F. Berkovic, Andrew Evans, Wendy Kelso, Sarah Farrand, Samantha M. Loi, Mark
Objective: People with neuropsychiatric symptoms often experience delay in accurate diagnosis. Although cerebrospinal fluid neurofilament light (CSF NfL) shows promise in distinguishing neurodegenerative disorders (ND) from psychiatric disorders (PSY), its accuracy in a diagnostically challenging cohort longitudinally is unknown.Methods: We collected longitudinal diagnostic information (mean = 36 months)
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Group independent components underpin responses to items from a depression scale Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-04-24 Drozdstoy Stoyanov, Vladimir Khorev, Rossitsa Paunova, Sevdalina Kandilarova, Semen Kurkin, Vince D. Calhoun
Objective The aim of the present study is to investigate the brain circuits or networks that underpin diagnostically specific tasks by means of group independent component analysis for FMRI toolbox (GIFT). We hypothesised that there will be neural network patterns of activation and deactivation, which correspond to real-time performance on clinical self-evaluation scales.Methods In total, 20 healthy
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Neuropeptide Y gene variants and Agreeableness: interaction effect with the birth cohort and the serotonin transporter promoter polymorphism Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-04-18 Evelyn Kiive, Margus Kanarik, Toomas Veidebaum, Jaanus Harro
Objective: Neuropeptide Y (NPY) is a powerful regulator of anxious states, including social anxiety, but evidence from human genetic studies is limited. Associations of common gene variants with behaviour have been described as subject to birth cohort effects, especially if the behaviour is socially motivated. This study aimed to examine the association of NPY rs16147 and rs5574 with personality traits
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Adverse childhood experiences and reoccurrence of illness impact the gut microbiome, which affects suicidal behaviours and the phenome of major depression: towards enterotypic phenotypes Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-04-13 Michael Maes, Asara Vasupanrajit, Ketsupar Jirakran, Pavit Klomkliew, Prangwalai Chanchaem, Chavit Tunvirachaisakul, Kitiporn Plaimas, Apichat Suratanee, Sunchai Payungporn
The first publication demonstrating that major depressive disorder (MDD) is associated with alterations in the gut microbiota appeared in 2008 (Maes et al., 2008). The purpose of the present study is to delineate a) the microbiome signature of the phenome of depression, including suicidal behaviours (SB) and cognitive deficits; the effects of adverse childhood experiences (ACEs) and recurrence of illness
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Has maternal sensitivity been comprehensively investigated in sub-Saharan Africa? A narrative scoping review Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-03-24 A. Prag, K.A. Donald, E. Weldon, S.L. Halligan, D.J. Stein, S. Malcolm-Smith
Child development is strongly influenced by maternal characteristics. Maternal sensitivity, as well as risks to and outcomes of sensitive maternal style, are well studied in industrialised western contexts, but it is unclear if this is the case for other contexts. Sub-Saharan Africa has been subjected to and continues to negotiate socio-economic and psychological sequelae of colonial and race-based
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Wearables measuring electrodermal activity to assess perceived stress in care: a scoping review Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-03-24 Agata Klimek, Ittay Mannheim, Gerard Schouten, Eveline J. M. Wouters, Manon W. H. Peeters
Background: Chronic stress responses can lead to physical and behavioural health problems, often experienced and observed in the care of people with intellectual disabilities or people with dementia. Electrodermal activity (EDA) is a bio-signal for stress, which can be measured by wearables and thereby support stress management. However, the how, when and to what extent patients and healthcare providers
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Reduction in hippocampal GABAergic transmission in a low birth weight rat model of depression Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-03-10 Zita Dósa, Jose Luis Nieto-Gonzalez, Betina Elfving, Karin Sørig Hougaard, Mai Marie Holm, Gregers Wegener, Kimmo Jensen
Prenatal stress is believed to increase the risk of developing neuropsychiatric disorders, including major depression. Adverse genetic and environmental impacts during early development, such as glucocorticoid hyper-exposure, can lead to changes in the foetal brain, linked to mental illnesses developed in later life. Dysfunction in the GABAergic inhibitory system is associated with depressive disorders
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Exploration of possible sex bias in acute social stress research: a semi-systematic review Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-03-06 Artemida Rrapaj, Anne M. Landau, Michael Winterdahl
Stress can have a significant impact on the daily lives of individuals and can increase vulnerability to a number of medical conditions. This study aims to estimate the ratio of male to female participants in acute social stress research in healthy individuals. We examined original research articles published over the last 20 years. Each article was screened to determine the total number of female
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The COVID-19 pandemic and obsessive-compulsive disorder: a systematic review of comparisons between males and females Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-03-02 Erfan Jalalifar, Amirreza Arad, Mohsen Rastkar, Rasa Beheshti
Coronavirus disease, one of the most disastrous epidemics, has caused a worldwide crisis, and the containment measures applied to decelerate the progression of the pandemic can increase the risk of obsessive-compulsive disorder (OCD). Identifying vulnerable groups in this area can lead us to better resource expenditure, and therefore, this systematic review aims to make a comparison between males and
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COVID-19 as a polymorphic inflammatory spectrum of diseases: a review with focus on the brain Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-03-02 Siu Wa Tang, Daiga Maret Helmeste, Brian E. Leonard
There appear to be huge variations and aberrations in the reported data in COVID-19 2 years now into the pandemic. Conflicting data exist at almost every level and also in the reported epidemiological statistics across different regions. It is becoming clear that COVID-19 is a polymorphic inflammatory spectrum of diseases, and there is a wide range of inflammation-related pathology and symptoms in
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Obstetric complications and clinical presentation in first episode of psychosis Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-03-02 Norma Verdolini, Gisela Mezquida, Isabel Valli, Clemente Garcia-Rizo, Manuel Cuesta, Eduard Vieta, Miquel Bioque, Antonio Lobo, Ana González-Pinto, Laura Pina-Camacho, Iluminada Corripio, Marina Garriga, Inmaculada Baeza, Laura Martínez-Sadurní, Byron Bitanihirwe, Mary Cannon, Miquel Bernardo, PEPs GROUP
Objective: Psychotic disorders exhibit a complex aetiology that combines genetic and environmental factors. Among the latter, obstetric complications (OCs) have been widely studied as risk factors, but it is not yet well understood how OCs relate to the heterogeneous presentations of psychotic disorders. We assessed the clinical phenotypes of individuals with a first episode of psychosis (FEP) in relation
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A single dose of cocaine raises SV2A density in hippocampus of adolescent rats Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-02-27 Rachele Rossi, Simone Larsen Bærentzen, Majken B. Thomsen, Caroline C. Real, Gregers Wegener, Rodrigo Grassi-Oliveira, Albert Gjedde, Anne M. Landau
Objective Cocaine is a highly addictive psychostimulant that affects synaptic activity with structural and functional adaptations of neurons. The transmembrane synaptic vesicle glycoprotein 2A (SV2A) of pre-synaptic vesicles is commonly used to measure synaptic density, as a novel approach to the detection of synaptic changes. We do not know if a single dose of cocaine suffices to affect pre-synaptic
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Cocaine-use disorder and childhood maltreatment are associated with the activation of neutrophils and increased inflammation Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-02-27 Giselle A. Funchal, Jaqueline B. Schuch, Aline Zaparte, Breno Sanvicente-Vieira, Thiago W. Viola, Rodrigo Grassi-Oliveira, Moisés E. Bauer
Background: Cocaine-use disorder (CUD) has been associated with early life adversity and activated cellular immune responses. Women are most vulnerable to complications from chronic substance disorders, generally presenting an intense feeling of abstinence and consuming significant drug amounts. Here, we investigated neutrophil functional activities in CUD, including the formation of neutrophil extracellular
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Dynamic impedance is correlated with static impedance and seizure quality parameters in bifrontal electroconvulsive therapy Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-02-21 Jan Exner, Gunnar Deuring, Erich Seifritz, Annette Beatrix Brühl
Background: To evoke a therapeutically effective seizure, electrical stimulation in electroconvulsive therapy (ECT) has to overcome the combined resistivity of scalp, skull and other tissues. Static impedances are measured prior to stimulation using high-frequency electrical alternating pulses, dynamic impedances during passage of the stimulation current. Static impedance can partially be influenced
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Cannabidiol modulates contextual fear memory consolidation in animals with experimentally induced type-1 diabetes mellitus Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-02-20 Yane Costa Chaves, Ana Maria Raymundi, Ana Paula Farias Waltrick, José Alexandre de Souza Crippa, Cristina Aparecida Jark Stern, Joice Maria da Cunha, Janaína Menezes Zanoveli
Objectives: In view of the neuroprotective characteristic of cannabidiol (CBD) and its beneficial action on aversive memory in non-diabetic animals, we aimed to investigate in animals with experimentally induced type-1 diabetes mellitus (T1DM) whether CBD treatment would be able to impair the contextual fear memory consolidation, its generalisation and whether the effect would be lasting. We also investigated
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Development and validation of the Male Post-coital Affect Scale for heterosexual men Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-02-15 Marta Pérez, Jørgen Hoppe, Anne M. Landau, Michael Winterdahl
Objective: The aim of this study was to examine the reliability and validity of the Male Post-coital Affect Scale (MPAS), which was developed to assess positive post-coital feelings in men.Methods: After a pilot study, we validated our scale on a sample of American heterosexual men, who answered our questionnaire on the internet through Amazon Mechanical Turk. We tested the reliability using internal
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Mediators of improved PTSD symptoms in veterans and civilians following a yoga program Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-01-30 Louanne W. Davis, Arlene A. Schmid, Joanne K. Daggy, Ziyi Yang
Objective: Although yoga shows some promise as an intervention for post-traumatic stress disorder (PTSD), little is known about how yoga reduces PTSD symptoms. The current study hypothesised that aspects of interoceptive awareness would mediate the effect of a yoga intervention on PTSD symptoms.Methods: We used data from our recently completed randomised controlled trial of a 16-week holistic yoga
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Is it possible to find reliable biomarkers to diagnose suicide risk? Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-01-30 Leo Sher
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Associations between community-level patterns of prenatal alcohol and tobacco exposure on brain structure in a non-clinical sample of 6-year-old children: a South African pilot study Acta Neuropsychiatr. (IF 3.8) Pub Date : 2023-01-26 Kristina A. Uban, Deborah Jonker, Kirsten A. Donald, Stefanie C. Bodison, Samantha J. Brooks, Eric Kan, Babette Steigelmann, Annerine Roos, Andrew Marshall, Shana Adise, Letitia Butler-Kruger, Brigitte Melly, Katherine L. Narr, Shantanu H. Joshi, Hein J. Odendaal, Elizabeth R. Sowell, Dan J. Stein
The current small study utilised prospective data collection of patterns of prenatal alcohol and tobacco exposure (PAE and PTE) to examine associations with structural brain outcomes in 6-year-olds and served as a pilot to determine the value of prospective data describing community-level patterns of PAE and PTE in a non-clinical sample of children. Participants from the Safe Passage Study in pregnancy