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A core scientific problem in the treatment of central nervous system diseases: newborn neurons Neural Regener. Res. (IF 6.1) Pub Date : 2024-04-01 Peng Hao, Zhaoyang Yang, Kwok-Fai So, Xiaoguang Li
It has long been asserted that failure to recover from central nervous system diseases is due to the system’s intricate structure and the regenerative incapacity of adult neurons. Yet over recent decades, numerous studies have established that endogenous neurogenesis occurs in the adult central nervous system, including humans’. This has challenged the long-held scientific consensus that the number
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MicroRNA-502-3p regulates GABAergic synapse function in hippocampal neurons Neural Regener. Res. (IF 6.1) Pub Date : 2024-03-01 Bhupender Sharma, Melissa M. Torres, Sheryl Rodriguez, Laxman Gangwani, Subodh Kumar
Gamma-aminobutyric acid (GABA)ergic neurons, the most abundant inhibitory neurons in the human brain, have been found to be reduced in many neurological disorders, including Alzheimer’s disease and Alzheimer’s disease-related dementia. Our previous study identified the upregulation of microRNA-502-3p (miR-502-3p) and downregulation of GABA type A receptor subunit α-1 in Alzheimer’s disease synapses
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Advances in spinal cord injury: insights from non-human primates Neural Regener. Res. (IF 6.1) Pub Date : 2024-01-31 Gaetan Poulen, Florence E. Perrin
Spinal cord injury results in significant sensorimotor deficits, currently, there is no curative treatment for the symptoms induced by spinal cord injury. Basic and pre-clinical research on spinal cord injury relies on the development and characterization of appropriate animal models. These models should replicate the symptoms observed in human, allowing for the exploration of functional deficits and
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Activation of autophagy by Citri Reticulatae Semen extract ameliorates amyloid-beta-induced cell death and cognition deficits in Alzheimer’s disease Neural Regener. Res. (IF 6.1) Pub Date : 2024-01-31 Yong Tang, Jing Wei, Xiao-Fang Wang, Tao Long, Xiaohong Xiang, Liqun Qu, Xingxia Wang, Chonglin Yu, Xingli Xiao, Xueyuan Hu, Jing Zeng, Qin Xu, Anguo Wu, Jianming Wu, Dalian Qin, Xiaogang Zhou, Betty Yuen-Kwan Law
Amyloid-beta-induced neuronal cell death contributes to cognitive decline in Alzheimer’s disease. Citri Reticulatae Semen has diverse beneficial effects on neurodegenerative diseases, including Parkinson’s and Huntington’s diseases, however, the effect of Citri Reticulatae Semen on Alzheimer’s disease remains unelucidated. In the current study, the anti-apoptotic and autophagic roles of Citri Reticulatae
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Association of DNA methylation/demethylation with the functional outcome of stroke in a hyperinflammatory state Neural Regener. Res. (IF 6.1) Pub Date : 2024-01-08 Yubo Wang, Ling Zhang, Tianjie Lyu, Lu Cui, Shunying Zhao, Xuechun Wang, Meng Wang, Yongjun Wang, Zixiao Li
Inflammation is closely related to stroke prognosis, and high inflammation status leads to poor functional outcome in stroke. DNA methylation is involved in the pathogenesis and prognosis of stroke. However, the effect of DNA methylation on stroke at high levels of inflammation is unclear. In this study, we constructed a hyperinflammatory cerebral ischemia mouse model and investigated the effect of
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Connecting cellular mechanisms and extracellular vesicle cargo in traumatic brain injury Neural Regener. Res. (IF 6.1) Pub Date : 2023-12-21 Nikita Ollen-Bittle, Austyn D. Roseborough, Wenxuan Wang, Jeng-liang D. Wu, Shawn N. Whitehead
Traumatic brain injury is followed by a cascade of dynamic and complex events occurring at the cellular level. These events include: diffuse axonal injury, neuronal cell death, blood-brain barrier break down, glial activation and neuroinflammation, edema, ischemia, vascular injury, energy failure, and peripheral immune cell infiltration. The timing of these events post injury has been linked to injury
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Exosomes derived from microglia overexpressing miR-124-3p alleviate neuronal endoplasmic reticulum stress damage after repetitive mild traumatic brain injury Neural Regener. Res. (IF 6.1) Pub Date : 2023-12-21 Yan Wang, Dai Li, Lan Zhang, Zhenyu Yin, Zhaoli Han, Xintong Ge, Meimei Li, Jing Zhao, Shishuang Zhang, Yan Zuo, Xiangyang Xiong, Han Gao, Qiang Liu, Fanglian Chen, Ping Lei
We previously reported that miR-124-3p is markedly upregulated in microglia-derived exosomes following repetitive mild traumatic brain injury. However, its impact on neuronal endoplasmic reticulum stress following repetitive mild traumatic brain injury remains unclear. In this study, we first used an HT22 scratch injury model to mimic traumatic brain injury, then co-cultured the HT22 cells with BV2
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Microglial NLRP3 inflammasome-mediated neuroinflammation and therapeutic strategies in depression Neural Regener. Res. (IF 6.1) Pub Date : 2023-12-15 Qiuqin Han, Wenhui Li, Peiqing Chen, Lijuan Wang, Xiwen Bao, Renyan Huang, Guobin Liu, Xiaorong Chen
Previous studies have demonstrated a bidirectional relationship between inflammation and depression. Activation of the nucleotide-binding oligomerization domain, leucine-rich repeat, and NLR family pyrin domain-containing 3 (NLRP3) inflammasomes is closely related to the pathogenesis of various neurological diseases. In patients with major depressive disorder, NLRP3 inflammasome levels are significantly
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Bromocriptine protects perilesional spinal cord neurons from lipotoxicity after spinal cord injury. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Ying Peng,Zhuoxuan Li,Zhiyang Zhang,Yinglun Chen,Renyuan Wang,Nixi Xu,Yuanwu Cao,Chang Jiang,Zixian Chen,Haodong Lin
Recent studies have revealed that lipid droplets accumulate in neurons after brain injury and evoke lipotoxicity, damaging the neurons. However, how lipids are metabolized by spinal cord neurons after spinal cord injury remains unclear. Herein, we investigated lipid metabolism by spinal cord neurons after spinal cord injury and identified lipid-lowering compounds to treat spinal cord injury. We found
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Epidemiological and clinical features, treatment status, and economic burden of traumatic spinal cord injury in China: a hospital-based retrospective study. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Hengxing Zhou,Yongfu Lou,Lingxiao Chen,Yi Kang,Lu Liu,Zhiwei Cai,David B Anderson,Wei Wang,Chi Zhang,Jinghua Wang,Guangzhi Ning,Yanzheng Gao,Baorong He,Wenyuan Ding,Yisheng Wang,Wei Mei,Yueming Song,Yue Zhou,Maosheng Xia,Huan Wang,Jie Zhao,Guoyong Yin,Tao Zhang,Feng Jing,Rusen Zhu,Bin Meng,Li Duan,Zhongmin Zhang,Desheng Wu,Zhengdong Cai,Lin Huang,Zhanhai Yin,Kainan Li,Shibao Lu,Shiqing Feng
Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even death. China has the largest population of patients with traumatic spinal cord injury. Previous studies of traumatic spinal cord injury in China have mostly been regional in scope; national-level studies have been rare. To the best of our knowledge, no national-level study of treatment status and economic
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Forebrain excitatory neuron-specific loss of Brpf1 attenuates excitatory synaptic transmission and impairs spatial and fear memory. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Baicheng Zhao,Hang Zhang,Ying Liu,Gaoyu Zu,Yuxiao Zhang,Jiayi Hu,Shuai Liu,Linya You
Bromodomain and plant homeodomain (PHD) finger containing protein 1 (Brpf1) is an activator and scaffold protein of a multiunit complex that includes other components involving lysine acetyltransferase (KAT) 6A/6B/7. Brpf1, KAT6A, and KAT6B mutations were identified as the causal genes of neurodevelopmental disorders leading to intellectual disability. Our previous work revealed strong and specific
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Increased retinal venule diameter as a prognostic indicator for recurrent cerebrovascular events: a prospective observational study. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Ying Zhao,Dawei Dong,Ding Yan,Bing Yang,Weirong Gui,Man Ke,Anding Xu,Zefeng Tan
Microvasculature of the retina is considered an alternative marker of cerebral vascular risk in healthy populations. However, the ability of retinal vasculature changes, specifically focusing on retinal vessel diameter, to predict the recurrence of cerebrovascular events in patients with ischemic stroke has not been determined comprehensively. While previous studies have shown a link between retinal
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Casein kinase-2 inhibition promotes retinal ganglion cell survival after acute intraocular pressure elevation. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Meng Wang,Shi-Qi Yao,Yao Huang,Jia-Jian Liang,Yanxuan Xu,Shaowan Chen,Yuhang Wang,Tsz Kin Ng,Wai Kit Chu,Qi Cui,Ling-Ping Cen
Intraocular pressure elevation can induce retinal ganglion cell death and is a clinically reversible risk factor for glaucoma, the leading cause of irreversible blindness. We previously demonstrated that casein kinase-2 inhibition can promote retinal ganglion cell survival and axonal regeneration in rats after optic nerve injury. To investigate the underlying mechanism, in the current study we increased
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Translocation of telomerase reverse transcriptase coincided with ATP release in postnatal cochlear supporting cells. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Yukai Zhang,Keyong Tian,Wei Wei,Wenjuan Mi,Fei Lu,Zhenzhen Liu,Qingwen Zhu,Xinyu Zhang,Panling Geng,Jianhua Qiu,Yongli Song,Dingjun Zha
The spontaneous bursts of electrical activity in the developing auditory system are derived from the periodic release of adenosine triphosphate (ATP) by supporting cells in the Kölliker's organ. However, the mechanisms responsible for initiating spontaneous ATP release have not been determined. Our previous study revealed that telomerase reverse transcriptase (TERT) is expressed in the basilar membrane
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P7C3-A20 treats traumatic brain injury in rats by inhibiting excessive autophagy and apoptosis. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Zhiqing Yang,Zhenchao Wang,Xiaoqi Deng,Lingxin Zhu,Zhaomeng Song,Changyu Cao,Xinran Li
Traumatic brain injury is a severe health problem leading to autophagy and apoptosis in the brain. 3,6-Dibromo-beta-fluoro-N-(3-methoxyphenyl)-9H-carbazole-9-propanamine (P7C3-A20) can be neuroprotective in various diseases, including ischemic stroke and neurodegenerative diseases. However, whether P7C3-A20 has a therapeutic effect on traumatic brain injury and its possible molecular mechanisms are
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Conditioned medium from human dental pulp stem cells treats spinal cord injury by inhibiting microglial pyroptosis. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Tao Liu,Ziqian Ma,Liang Liu,Yilun Pei,Qichao Wu,Songjie Xu,Yadong Liu,Nan Ding,Yun Guan,Yan Zhang,Xueming Chen
Human dental pulp stem cell transplantation has been shown to be an effective therapeutic strategy for spinal cord injury. However, whether the human dental pulp stem cell secretome can contribute to functional recovery after spinal cord injury remains unclear. In the present study, we established a rat model of spinal cord injury based on impact injury from a dropped weight and then intraperitoneally
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Cortical activity in patients with high-functioning ischemic stroke during the Purdue Pegboard Test: insights into bimanual coordinated fine motor skills with functional near-infrared spectroscopy. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Siyun Chen,Mengchai Mao,Guangyue Zhu,Yufeng Chen,Yuqi Qiu,Bin Ye,Dongsheng Xu
After stroke, even high-functioning individuals may experience compromised bimanual coordination and fine motor dexterity, leading to reduced functional independence. Bilateral arm training has been proposed as a promising intervention to address these deficits. However, the neural basis of the impairment of functional fine motor skills and their relationship to bimanual coordination performance in
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ATAT1 deficiency enhances microglia/macrophage-mediated erythrophagocytosis and hematoma absorption following intracerebral hemorrhage. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Yihua Zhang,Ping Huang,Min Cao,Yi Chen,Xinhu Zhao,Xuzhi He,Lunshan Xu
MIcroglia/macrophage-mediated erythrophagocytosis plays a crucial role in hematoma clearance after intracerebral hemorrhage. Dynamic cytoskeletal changes accompany phagocytosis. However, whether and how these changes are associated with microglia/macrophage-mediated erythrophagocytosis remain unclear. In this study, we investigated the function of acetylated α-tubulin, a stabilized microtubule form
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Satellite glial cells in sensory ganglia play a wider role in chronic pain via multiple mechanisms. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Xiaoyun Qiu,Yuanzhi Yang,Xiaoli Da,Yi Wang,Zhong Chen,Cenglin Xu
Satellite glial cells are unique glial cells that surround the cell body of primary sensory neurons. An increasing body of evidence suggests that in the presence of inflammation and nerve damage, a significant number of satellite glial cells become activated, thus triggering a series of functional changes. This suggests that satellite glial cells are closely related to the occurrence of chronic pain
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The miR-9-5p/CXCL11 pathway is a key target of hydrogen sulfide-mediated inhibition of neuroinflammation in hypoxic ischemic brain injury. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Yijing Zhao,Tong Li,Zige Jiang,Chengcheng Gai,Shuwen Yu,Danqing Xin,Tingting Li,Dexiang Liu,Zhen Wang
We previously showed that hydrogen sulfide (H2S) has a neuroprotective effect in the context of hypoxic ischemic brain injury in neonatal mice. However, the precise mechanism underlying the role of H2S in this situation remains unclear. In this study, we used a neonatal mouse model of hypoxic ischemic brain injury and a lipopolysaccharide-stimulated BV2 cell model and found that treatment with L-cysteine
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Endorepellin downregulation promotes angiogenesis after experimental traumatic brain injury. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Qian Zhang,Yao Jing,Qiuyuan Gong,Lin Cai,Ren Wang,Dianxu Yang,Liping Wang,Meijie Qu,Hao Chen,Yaohui Tang,Hengli Tian,Jun Ding,Zhiming Xu
Endorepellin plays a key role in the regulation of angiogenesis, but its effects on angiogenesis after traumatic brain injury are unclear. This study explored the effects of endorepellin on angiogenesis and neurobehavioral outcomes after traumatic brain injury in mice. Mice were randomly divided into four groups: sham, controlled cortical impact only, adeno-associated virus (AAV)-green fluorescent
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Promising use of metformin in treating neurological disorders: biomarker-guided therapies. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Allison Loan,Charvi Syal,Margarita Lui,Ling He,Jing Wang
Neurological disorders are a diverse group of conditions that affect the nervous system and include neurodegenerative diseases (Alzheimer's disease, multiple sclerosis, Parkinson's disease, Huntington's disease), cerebrovascular conditions (stroke), and neurodevelopmental disorders (autism spectrum disorder). Although they affect millions of individuals around the world, only a limited number of effective
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Ferroptosis: a potential therapeutic target for stroke. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Chengli Liu,Guijun Wang,Wenrui Han,Qi Tian,Mingchang Li
Ferroptosis is a form of regulated cell death characterized by massive iron accumulation and iron-dependent lipid peroxidation, differing from apoptosis, necroptosis, and autophagy in several aspects. Ferroptosis is regarded as a critical mechanism of a series of pathophysiological reactions after stroke because of iron overload caused by hemoglobin degradation and iron metabolism imbalance. In this
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New insights into the therapeutic approaches for the treatment of tauopathies. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Himanshi Singh,Asmita Das,Mohammad Moshahid Khan,Tayebeh Pourmotabbed
Tauopathies are a group of neurological disorders, including Alzheimer's disease and frontotemporal dementia, which involve progressive neurodegeneration, cognitive deficits, and aberrant tau protein accumulation. The development of tauopathies cannot currently be stopped or slowed down by treatment measures. Given the significant contribution of tau burden in primary tauopathies and the strong association
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Pathological mechanisms of amyotrophic lateral Sclerosis. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Yushu Hu,Wenzhi Chen,Caihui Wei,Shishi Jiang,Shu Li,Xinxin Wang,Renshi Xu
Amyotrophic lateral sclerosis refers to a neurodegenerative disease involving the motor system, the cause of which remains unexplained despite several years of research. Thus, the journey to understanding or treating amyotrophic lateral sclerosis is still a long one. According to current research, amyotrophic lateral sclerosis is likely not due to a single factor but rather to a combination of mechanisms
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Progress in the generation of spinal cord organoids over the past decade and future perspectives. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Gang Zhou,Siyuan Pang,Yongning Li,Jun Gao
Spinal cord organoids are three-dimensional tissues derived from stem cells that recapitulate the primary morphological and functional characteristics of the spinal cord in vivo. As emerging bioengineering methods have led to the optimization of cell culture protocols, spinal cord organoids technology has made remarkable advancements in the past decade. Our literature search found that current spinal
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Antisense therapy: a potential breakthrough in the treatment of neurodegenerative diseases. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Roberta Romano,Cecilia Bucci
Neurodegenerative diseases are a group of disorders characterized by the progressive degeneration of neurons in the central or peripheral nervous system. Currently, there is no cure for neurodegenerative diseases and this means a heavy burden for patients and the health system worldwide. Therefore, it is necessary to find new therapeutic approaches, and antisense therapies offer this possibility, having
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NRF2 signaling cascade in amyotrophic lateral sclerosis: bridging the gap between promise and reality. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Pauline Tarot,Christelle Lasbleiz,Jean-Charles Liévens
Amyotrophic lateral sclerosis is a very disabling disease due to the degeneration of motor neurons. Symptoms include muscle weakness and atrophy, spasticity, and progressive paralysis. Currently, there is no treatment to reverse damage to motor neurons and cure amyotrophic lateral sclerosis. The only two treatments actually approved, riluzole and edaravone, have shown mitigated beneficial effects.
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Assistive techniques and their added value for tremor classification in multiple sclerosis. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Nabin Koirala,Abdulnasir Hossen,Ioannis U Isaias,Jens Volkmann,Muthuraman Muthuraman
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Focusing on the tetra-partite synapse in Parkinson's disease research using human patient-derived neurons. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Diogo Cordeiro,Tchelet Stern,Shani Stern
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Two become one: combination of two risk factors in a new glaucoma animal model. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Nils Kluge,Sabrina Reinehr
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Perspectives for delivery of therapeutics by extravasation of biodegradable microspheres in the brain. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Anne-Eva van der Wijk,Ed VanBavel
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Role of lysosomal trafficking regulator in autophagic lysosome reformation in neurons: a disease perspective. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Prashant Sharma,Jenny Serra-Vinardell,Wendy J Introne,May Christine V Malicdan
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Mitochondria replacement from transplanted amniotic fluid stem cells: a promising therapy for non-neuronal defects in spinal muscular atrophy. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Michela Pozzobon,Camilla Bean
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Soluble alpha-synuclein post-translational modifications: unexpected regulators of pathological alpha-synuclein amplification. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Simran Kapila,Yuhan Sun,Chao Peng,Shujing Zhang
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New insights into the effects of APP gene dose on synapse in Down syndrome. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Xu-Qiao Chen,Xinxin Zuo
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Protein glycation: a wolf in sweet sheep's clothing behind neurodegeneration. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Ana B Uceda,Francisco Leal-Pérez,Miquel Adrover
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Anti-aquaporin-4 antibody (AQP4-IgG) and anti-myelin oligodendrocyte glycoprotein antibody (MOG-IgG) in the cerebrospinal fluid. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Tetsuya Akaishi,Tatsuro Misu
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Phosphorylation-driven aggregative proteins in neurodegenerative diseases: implications and therapeutics. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Alba Espargaró,Raimon Sabate
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Is GDNF to Parkinson's disease what BDNF is to Huntington's disease? Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Francesca R Fusco,Emanuela Paldino
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TDP-43 is a key molecule accelerating development of Alzheimer's disease following traumatic brain injury. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Chu Chen
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Disentangling brain PrPC proteoforms and their roles in physiology and disease. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Ilaria Vanni,Nonno Romolo
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Does photobiomodulation require glucose to work effectively? Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Jaimie Hoh Kam,John Mitrofanis
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Autophagy in neuroinflammation after traumatic brain injury. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Chinmoy Sarkar,Marta M Lipinski
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Perspectives in human brain plasticity sparked by glioma invasion: from intraoperative (re)mappings to neural reconfigurations. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Sam Ng,Hugues Duffau,Guillaume Herbet
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Targeting epidermal growth factor receptor signaling to facilitate cortical injury repair? Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Ricardo Gómez-Oliva,Pedro Nunez-Abades,Carmen Castro
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Neurological consequences of human calmodulin mutations. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Helene H Jensen,Anders Olsen
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Beyond functional MRI signals: molecular and cellular modifiers of the functional connectome and cognition. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Lorenzo Pini,Alessandro Salvalaggio,Maurizio Corbetta
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From the dust: extracellular vesicles as regulators of development and neuroregeneration. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Leon G Coleman
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Targeting autophagy by polyphenols to prevent glycative stress-toxicity in the brain. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Alejandro Ponce-Mora,Eloy Bejarano
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Alpha7 nicotinic receptors as potential theranostic targets for experimental stroke. Neural Regener. Res. (IF 6.1) Pub Date : 2024-05-01 Maider Garbizu,Laura Aguado,Abraham Martín
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Anti-vascular endothelial growth factor drugs combined with laser photocoagulation maintain retinal ganglion cell integrity in patients with diabetic macular edema: study protocol for a prospective, non-randomized, controlled clinical trial. Neural Regener. Res. (IF 6.1) Pub Date : 2024-04-01 Xiangjun Li,Chunyan Li,Hai Huang,Dan Bai,Jingyi Wang,Anqi Chen,Yu Gong,Ying Leng
The integrity of retinal ganglion cells is tightly associated with diabetic macular degeneration that leads to damage and death of retinal ganglion cells, affecting vision. The major clinical treatments for diabetic macular edema are anti-vascular endothelial growth factor drugs and laser photocoagulation. However, although the macular thickness can be normalized with each of these two therapies used
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STAT3 ameliorates truncated tau-induced cognitive deficits. Neural Regener. Res. (IF 6.1) Pub Date : 2024-04-01 Bingge Zhang,Huali Wan,Maimaitijian Maierwufu,Qian Liu,Ting Li,Ye He,Xin Wang,Gongping Liu,Xiaoyue Hong,Qiong Feng
Proteolytic cleavage of tau by asparagine endopeptidase (AEP) creates tau-N368 fragments, which may drive the pathophysiology associated with synaptic dysfunction and memory deterioration in the brain of Alzheimer's disease patients. Nonetheless, the molecular mechanisms of truncated tau-induced cognitive deficits remain unclear. Evidence suggests that signal transduction and activator of transcription-3
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Human umbilical cord mesenchymal stem cell-derived exosomes loaded into a composite conduit promote functional recovery after peripheral nerve injury in rats. Neural Regener. Res. (IF 6.1) Pub Date : 2024-04-01 Haoshuai Tang,Junjin Li,Hongda Wang,Jie Ren,Han Ding,Jun Shang,Min Wang,Zhijian Wei,Shiqing Feng
Complete transverse injury of peripheral nerves is challenging to treat. Exosomes secreted by human umbilical cord mesenchymal stem cells are considered to play an important role in intercellular communication and regulate tissue regeneration. In previous studies, a collagen/hyaluronic acid sponge was shown to provide a suitable regeneration environment for Schwann cell proliferation and to promote
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In vivo imaging of the neuronal response to spinal cord injury: a narrative review. Neural Regener. Res. (IF 6.1) Pub Date : 2024-04-01 Junhao Deng,Chang Sun,Ying Zheng,Jianpeng Gao,Xiang Cui,Yu Wang,Licheng Zhang,Peifu Tang
Deciphering the neuronal response to injury in the spinal cord is essential for exploring treatment strategies for spinal cord injury (SCI). However, this subject has been neglected in part because appropriate tools are lacking. Emerging in vivo imaging and labeling methods offer great potential for observing dynamic neural processes in the central nervous system in conditions of health and disease
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Blockade of Rho-associated kinase prevents inhibition of axon regeneration of peripheral nerves induced by anti-ganglioside antibodies. Neural Regener. Res. (IF 6.1) Pub Date : 2024-04-01 Andrés Berardo,Cristian R Bacaglio,Bárbara B Báez,Rubén Sambuelli,Kazim A Sheikh,Pablo H H Lopez
Anti-ganglioside antibodies are associated with delayed/poor clinical recovery in Guillain-Barrè syndrome, mostly related to halted axon regeneration. Cross-linking of cell surface gangliosides by anti-ganglioside antibodies triggers inhibition of nerve repair in in vitro and in vivo paradigms of axon regeneration. These effects involve the activation of the small GTPase RhoA/ROCK signaling pathways
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Multiple factors to assist human-derived induced pluripotent stem cells to efficiently differentiate into midbrain dopaminergic neurons. Neural Regener. Res. (IF 6.1) Pub Date : 2024-04-01 Yalan Chen,Junxin Kuang,Yimei Niu,Hongyao Zhu,Xiaoxia Chen,Kwok-Fai So,Anding Xu,Lingling Shi
Midbrain dopaminergic neurons play an important role in the etiology of neurodevelopmental and neurodegenerative diseases. They also represent a potential source of transplanted cells for therapeutic applications. In vitro differentiation of functional midbrain dopaminergic neurons provides an accessible platform to study midbrain neuronal dysfunction and can be used to examine obstacles to dopaminergic
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Long non-coding RNA H19 regulates neurogenesis of induced neural stem cells in a mouse model of closed head injury. Neural Regener. Res. (IF 6.1) Pub Date : 2024-04-01 Mou Gao,Qin Dong,Zhijun Yang,Dan Zou,Yajuan Han,Zhanfeng Chen,Ruxiang Xu
Stem cell-based therapies have been proposed as a potential treatment for neural regeneration following closed head injury. We previously reported that induced neural stem cells exert beneficial effects on neural regeneration via cell replacement. However, the neural regeneration efficiency of induced neural stem cells remains limited. In this study, we explored differentially expressed genes and long
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Genetic and epigenetic targets of natural dietary compounds as anti-Alzheimer's agents. Neural Regener. Res. (IF 6.1) Pub Date : 2024-04-01 Willian Orlando Castillo-Ordoñez,Nohelia Cajas-Salazar,Mayra Alejandra Velasco-Reyes
Alzheimer's disease is a progressive neurodegenerative disorder and the most common cause of dementia that principally affects older adults. Pathogenic factors, such as oxidative stress, an increase in acetylcholinesterase activity, mitochondrial dysfunction, genotoxicity, and neuroinflammation are present in this syndrome, which leads to neurodegeneration. Neurodegenerative pathologies such as Alzheimer's