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Great toe drop: Raison D'etre for ultrasound-guided electromyography Neurophysiol. Clin. (IF 3.0) Pub Date : 2024-03-29 Mahmud Fazıl Aksakal, Ahmad Jasem Abdulsalam, Ayşen Akıncı, Bayram Kaymak, Levent Özçakar
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Toward an electroclinical approach for neurophysiological hypersomnolence in sleep medicine Neurophysiol. Clin. (IF 3.0) Pub Date : 2024-03-14 Jean-Arthur Micoulaud-Franchi, Régis Lopez, Aileen McGonigal, Lino Nobili
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Sleepiness and the transition from wakefulness to sleep Neurophysiol. Clin. (IF 3.0) Pub Date : 2024-03-08 Thomas Andrillon, Jacques Taillard, Mélanie Strauss
The transition from wakefulness to sleep is a progressive process that is reflected in the gradual loss of responsiveness, an alteration of cognitive functions, and a drastic shift in brain dynamics. These changes do not occur all at once. The sleep onset period (SOP) refers here to this period of transition between wakefulness and sleep. For example, although transitions of brain activity at sleep
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Efficacy of spinal cord stimulation as an adjunctive therapy in heart failure: A systematic review Neurophysiol. Clin. (IF 3.0) Pub Date : 2024-02-28 Sahand Ashrafpour, Manouchehr Ashrafpour
Neuromodulation therapy, like spinal cord stimulation (SCS), benefits individuals with chronic diseases, improving outcomes of patients with heart failure (HF). This systematic review aims to investigate the efficacy of SCS when used as an adjunctive therapy in HF. A systematic analysis of all studies that included SCS therapy in human participants with HF was conducted. After excluding studies not
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Correlation with sympathetic skin response, 123I-MIBG scintigraphy, and 123I-FP-CIT SPECT in Parkinson's disease Neurophysiol. Clin. (IF 3.0) Pub Date : 2024-02-28 Masakazu Ozawa, Ryo Morishima, Toshio Shimizu, Kazushi Takahashi
Parkinson's disease (PD), and other parkinsonian syndromes are known to cause striatonigral dopaminergic system dysfunction and autonomic disturbances, including the vasomotor and sudomotor nervous systems. The detection of I-FP-CIT SPECT (DaT scan) imaging and autonomic dysfunction helps differentiate PD from multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). The sympathetic skin
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Predictive value of heart rate variability and electrochemical skin conductance measurements for cardiovascular autonomic neuropathy persistence in type 2 diabetes and prediabetes: A 3-year follow-up study Neurophysiol. Clin. (IF 3.0) Pub Date : 2024-02-28 Yun-Ru Lai, Chih-Cheng Huang, Wen-Chan Chiu, Ben-Chung Cheng, Ting-Yin Lin, Hui-Ching Chiang, Cheng-Hsien Lu
The study aimed to explore risk stratification approaches for cardiovascular autonomic neuropathy (CAN) in individuals with prediabetes and type 2 diabetes (T2DM) over a three-year follow-up period. Participants underwent evaluations of autonomic function encompassing cardiovascular autonomic reflex tests (CARTs), baroreflex sensitivity (BRS), heart rate variability (HRV) in time domains (standard
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Epilepsy with eyelid myoclonia (Jeavons syndrome): Generalized, focal, or combined generalized and focal epilepsy syndrome? Neurophysiol. Clin. (IF 3.0) Pub Date : 2024-02-28 Philippe Gélisse, Carlos Gallegos, Annacarmen Nilo, Greta Macorig, Pierre Genton, Arielle Crespel
Epilepsy with eyelid myoclonia (EM) or Jeavons syndrome (JS) is an epileptic syndrome related to the spectrum of genetic generalized epilepsies (GGE). We report two untreated children on which EEGs were performed several hours after a generalized tonic-clonic seizure (GTCS). These showed a unilateral, nearly continuous posterior slowing. This slow-wave activity was associated with contralateral epileptiform
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Investigation of small fiber neuropathy in patients with diabetes mellitus by corneal confocal microscopy Neurophysiol. Clin. (IF 3.0) Pub Date : 2024-02-28 Hatice Kaplan, Sema Yüzbaşıoğlu, Gönül Vural, Şadiye Gümüşyayla
Corneal confocal microscopy (CCM) is a non-invasive technique that examines the corneal cellular structure. Its use in the detection of small fiber neuropathy is being researched. In our study, we examined the role of CCM in the detection of small fiber neuropathy in diabetic patients, as well as the differences between CCM findings in diabetic patients with and without overt polyneuropathy with neuropathic
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Sleepiness should be reinvestigated through the lens of clinical neurophysiology: A mixed expertal and big-data Natural Language Processing approach Neurophysiol. Clin. (IF 3.0) Pub Date : 2024-02-23 Vincent P. Martin, Christophe Gauld, Jacques Taillard, Laure Peter-Derex, Régis Lopez, Jean-Arthur Micoulaud-Franchi
Historically, the field of sleep medicine has revolved around electrophysiological tools. However, the use of these tools as a neurophysiological method of investigation seems to be underrepresented today, from both international recommendations and sleep centers, in contrast to behavioral and psychometric tools. The aim of this article is to combine a data-driven approach and neurophysiological and
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Objective evaluation of excessive daytime sleepiness Neurophysiol. Clin. (IF 3.0) Pub Date : 2024-02-23 Jacques Taillard, Jean Arthur Micoulaud-Franchi, Vincent P. Martin, Laure Peter-Derex, Marie Françoise Vecchierini
Excessive daytime sleepiness (EDS) is multifactorial. It combines, among other things, an excessive propensity to fall asleep (“physiological sleepiness”) and a continuous non-imperative sleepiness (or drowsiness/hypo-arousal) leading to difficulties remaining awake and maintaining sustained attention and vigilance over the long term (“manifest sleepiness”). There is no stand-alone biological measure
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Long sleep time and excessive need for sleep: State of the art and perspectives Neurophysiol. Clin. (IF 3.0) Pub Date : 2024-02-22 Elisa Evangelista, Smaranda Leu-Semenescu, Fabio Pizza, Giuseppe Plazzi, Yves Dauvilliers, Lucie Barateau, Isabelle Lambert
The mechanisms underlying the individual need for sleep are unclear. Sleep duration is indeed influenced by multiple factors, such as genetic background, circadian and homeostatic processes, environmental factors, and sometimes transient disturbances such as infections. In some cases, the need for sleep dramatically and chronically increases, inducing a daily-life disability. This “excessive need for
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From physiological awakening to pathological sleep inertia: Neurophysiological and behavioural characteristics of the sleep-to-wake transition Neurophysiol. Clin. (IF 3.0) Pub Date : 2024-02-22 Perrine Ruby, Elisa Evangelista, Hélène Bastuji, Laure Peter-Derex
Sleep inertia refers to the transient physiological state of hypoarousal upon awakening, associated with various degrees of impaired neurobehavioral performance, confusion, a desire to return to sleep and often a negative emotional state. Scalp and intracranial electro-encephalography as well as functional imaging studies have provided evidence that the sleep inertia phenomenon is underpinned by an
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Can epilepsy affect normal EEG variants? A comparative study between subjects with and without epilepsy Neurophysiol. Clin. (IF 3.0) Pub Date : 2024-02-22 Greta Macorig, Arielle Crespel, Annacarmen Nilo, Ngoc Phuong Loc Tang, Gian Luigi Gigli, Philippe Gélisse
To compare the prevalence of benign EEG variants (BEVs) between epileptic and non-epileptic subjects. A prospective, observational EEG study of 1,163 consecutive patients, using the 10–20 international system with systematically two additional anterior/inferior temporal electrodes. The video-EEG monitoring duration was between 24 h and eight days. We identified 917 (78.9%) epileptic patients (mean
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Efficacy and safety of transcranial direct current stimulation in the treatment of fibromyalgia: A systematic review and meta-analysis Neurophysiol. Clin. (IF 3.0) Pub Date : 2024-02-21 Chun-Lan Yang, Yun Qu, Jia-Peng Huang, Ting-Ting Wang, Han Zhang, Yin Chen, Ying-Chao Tan
To update a systematic review of the efficacy and safety of transcranial direct current stimulation (tDCS) for analgesia, for antidepressant effects, and to reduce the impact of fibromyalgia (FM), looking for optimal areas of stimulation. We searched five databases to identify randomized controlled trials comparing active and sham tDCS for FM. The primary outcome was pain intensity, and secondary outcome
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Sensory symptoms relieved by navigated rTMS, targeted using lesion network mapping based on human brain connectome, in a patient after thalamic stroke Neurophysiol. Clin. (IF 3.0) Pub Date : 2024-02-20 Mengdan Zhang, Xiaohui Xie, Yuqian Zhan, Yu Jiang, Tongjian Bai, Long Zhang, Kai Wang, Gong-Jun Ji, Yanghua Tian
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Asymmetrical/unilateral ocular artifacts on EEG Neurophysiol. Clin. (IF 3.0) Pub Date : 2024-02-20 Philippe Gélisse, Arielle Crespel
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It is time to personalize rTMS targeting for the treatment of pain Neurophysiol. Clin. (IF 3.0) Pub Date : 2024-02-20 J, e, a, n, -, P, a, s, c, a, l, , L, e, f, a, u, c, h, e, u, r
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Distinct patterns of metabolic motor cortex activity for phantom and residual limb pain in people with amputations: A functional near-infrared spectroscopy study Neurophysiol. Clin. (IF 3.0) Pub Date : 2024-02-20 Marcel Simis, Lucas Murrins Marques, Sara Pinto Barbosa, André Tadeu Sugawara, João Ricardo Sato, Kevin Pacheco-Barrios, Linamara Rizzo Battistella, Felipe Fregni
Phantom pain limb (PLP) has gained more attention due to the large number of people with amputations around the world and growing knowledge of the pain process, although its mechanisms are not completely understood. The aim of this study was to understand, in patients with amputations, the association between PLP and residual limb pain (RLP), and the brain metabolic response in cortical motor circuits
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Impact of textured surfaces on the orthostatic balance of patients with multiple sclerosis Neurophysiol. Clin. (IF 3.0) Pub Date : 2024-02-20 Nathalie Bonardet, Benjamin Bardel, Jean-Pascal Lefaucheur, Marc Sorel, Alain Créange
To perform posturographic measurements with eyes open or closed using floor coverings with different textured surfaces to study postural control in patients with multiple sclerosis (MS). Static posturographic recordings were performed with eyes open and eyes closed on a forceplate with no covering (control condition) or covered by a textured mat with small pimples (height 2 mm) or large pimples (height
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Higher cortical excitability to negative emotions involved in musculoskeletal pain in Parkinson's disease Neurophysiol. Clin. (IF 3.0) Pub Date : 2024-02-20 Ming Liu, Hanying Gu, Jingzhe Hu, Manhua Liu, Yajun Luo, Yuan Yuan, Jiayu Wu, Yan Zhou, Ru Juan, Xiaoyu Cheng, Sheng Zhuang, Yun Shen, Hong Jin, Jing Chen, Kai Li, Fen Wang, Chunfeng Liu, Chengjie Mao
Changes in brain structure and neurotransmitter systems are involved in pain in Parkinson's disease (PD), and emotional factors are closely related to pain. Our study applied electroencephalography (EEG) to investigate the role of emotion in PD patients with chronic musculoskeletal pain. Forty-two PD patients with chronic musculoskeletal pain and 38 without were enrolled. EEG data were recorded under
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Long-interval afferent inhibition measurement using two different methods: Normative values, repeatability and reliability Neurophysiol. Clin. (IF 3.0) Pub Date : 2024-02-20 Hürrem Evren Boran, Halil Can Alaydın, Hasan Kılınç, Hatice Tankişi, Ginte Samusyte, James Howells, Martin Koltzenburg, Bülent Cengiz
The mechanism of Short-Latency Afferent Inhibition (SAI) is relatively well understood. In contrast, Long-Latency Afferent Inhibition (LAI) has not been as extensively studied as SAI, and its underlying mechanism remains unclear. This study had two primary objectives: first, to determine the optimal ISIs for LAI measured by amplitude changes (A-LAI) using high-resolution ISI ranges; and second, to
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The effects of anodal tDCS on pain reduction in people with knee osteoarthritis: A systematic review and meta-analysis Neurophysiol. Clin. (IF 3.0) Pub Date : 2023-11-18 Thusharika Dissanayaka, Piumi Nakandala, Kavinda Malwanage, Aron T. Hill, Deborah N. Ashthree, Melissa M. Lane, Nikolaj Travicia, Elizabeth Gamage, Wolfgang Marx, Shapour Jaberzadeh
Objectives To synthesise the literature on the efficacy of primary motor cortex anodal transcranial direct current stimulation (M1-a-tDCS), as a standalone or priming technique, for pain reduction in people with knee osteoarthritis (KOA). Methods The systematic literature search was conducted in MEDLINE, CINAHL, Embase and CENTRAL according to PRISMA statement. Results Fourteen studies involving 740
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Suboptimal postnatal function of brainstem auditory pathway in late preterm infants who do not have major perinatal and postnatal complications Neurophysiol. Clin. (IF 3.0) Pub Date : 2023-11-18 Cui Wang, James K. Jiang, Rong Yin, Ze D. Jiang
Objectives To examine postnatal functional status of the brainstem auditory pathway in late preterm infants and detect any postnatal auditory abnormality. Methods Thirty preterm infants born at 33–36 weeks gestation were studied three months after term. None had major perinatal and postnatal complications to minimize confounding effects. Brainstem auditory evoked responses were recorded with 21–91/s
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tDCS for pain management in knee osteoarthritis: A plea for noninvasive brain stimulation techniques in neuromusculoskeletal rehabilitation Neurophysiol. Clin. (IF 3.0) Pub Date : 2023-11-15 Samira Cutts, Alexander T. Sack
Abstract not available
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Efficacy of transcranial direct current stimulation in patients with knee osteoarthritis: A systematic review Neurophysiol. Clin. (IF 3.0) Pub Date : 2023-11-08 Fatemeh Rahimi, Meissam Sadeghisani, Atefeh Karimzadeh
Objective Transcranial direct current stimulation (tDCS) has demonstrated its efficacy in alleviating pain among individuals with musculoskeletal disorders. This review focuses on the application of tDCS as a therapeutic intervention for managing knee osteoarthritis (OA), a prevalent musculoskeletal condition. The primary objective is to assess the effectiveness of tDCS(add-on tDCS and /or stand-alone
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OPRM1 and BDNF polymorphisms associated with a compensatory neurophysiologic signature in knee osteoarthritis patients Neurophysiol. Clin. (IF 3.0) Pub Date : 2023-11-07 Fernanda de Toledo Gonçalves, Lucas Murrins Marques, Anne Victório Pessotto, Sara Pinto Barbosa, Marta Imamura, Marcel Simis, Felipe Fregni, Linamara Battistella
Objective The present study investigated the relationship between three genetic polymorphisms of OPRM1 (rs1799971 - A118G and rs1799972 - C17T) and BDNF (rs6265 - C196T) and EEG-measured brain oscillations in Knee Osteoarthritis (KOA) patients. Materials and Methods We performed a cross-sectional analysis of a cohort study (DEFINE cohort), KOA arm, with 66 patients, considering demographic (age, sex
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Influence of clinical and tumor-specific factors on the resting motor threshold in navigated transcranial magnetic stimulation Neurophysiol. Clin. (IF 3.0) Pub Date : 2023-11-07 Thomas Eibl, Michael Schrey, Adrian Liebert, Leonard Ritter, Rüdiger Lange, Hans-Herbert Steiner, Karl-Michael Schebesch
Objective Preoperative non-invasive mapping of motor function with navigated transcranial magnetic stimulation (nTMS) has become a widely used diagnostic procedure. Determination of the patient-individual resting motor threshold (rMT) is of great importance to achieve reliable results when conducting nTMS motor mapping. Factors which contribute to differences in rMT of brain tumor patients have not
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Sudoscan as substitute for quantitative sudomotor axon reflex test in composite autonomic scoring scale and its correlation with composite autonomic symptom scale 31 in type 2 diabetes Neurophysiol. Clin. (IF 3.0) Pub Date : 2023-11-03 Chih-Cheng Huang, Yun-Ru Lai, Ben-Chung Cheng, Wen-Chan Chiu, Ting Yin Lin, Hui Ching Chiang, Chun-En Aurea Kuo, Cheng-Hsien Lu
Objective This study aims to evaluate the feasibility of substituting electrochemical skin conductance measurement using SUDOSCAN for sudomotor function testing in the Composite Autonomic Scoring Scale (CASS) and to correlate the results with the Composite Autonomic Symptom Scale 31 (COMPASS 31) among patients with type 2 diabetes mellitus (T2DM). Methods Fifty patients with T2DM underwent cardiovascular
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A computational analysis of transcranial magnetic stimulation in patients with cranial defects and skull plate implants Neurophysiol. Clin. (IF 3.0) Pub Date : 2023-11-04 Minmin Wang, Li Zhang
We utilized computational analysis to investigate the impact of skull defects and skull implants on the TMS-induced EF. Our findings revealed a noteworthy alteration in the induced EF when acute skull defects were present. When high-conductivity titanium plates were used, we observed a pronounced increase in the peak EF, accompanied by a shift in the induced EF from the center towards both ends of
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Increased theta-low gamma phase-amplitude coupling in resting electroencephalography after intermittent theta burst stimulation Neurophysiol. Clin. (IF 3.0) Pub Date : 2023-10-05 Jie Zhang, Chunwei Ying, Zhenying Qian, Xiong Jiao, Xiaochen Tang, Gai Kong, Junfeng Sun, Jijun Wang, Yingying Tang
Objective Intermittent theta burst stimulation (iTBS) is based on the phase-amplitude coupling (PAC) pattern. We aimed to investigate the effect of iTBS on PAC in resting electroencephalography (EEG), which may provide insight into the underlying mechanism. Methods Twenty-one healthy volunteers were recruited and received both active and sham neuroimaging-guided iTBS on two separate days, which was
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Patients with epilepsy without cognitive impairment show altered brain networks in multiple frequency bands in an audiovisual integration task Neurophysiol. Clin. (IF 3.0) Pub Date : 2023-09-01 Yang Xi, Zhu Lan, Ying Chen, Qiushi Zhang, Zhenyu Wu, Guangjian Li
Objectives Comorbid cognitive and behavioral deficits are often observed in patients with epilepsy. It is not clear whether the brain networks of patients with epilepsy without cognitive decline differs from that of healthy controls in different frequency bands in the task-state. The purpose of our study was to explore whether epilepsy affects the structure of brain networks associated with cognitive
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Iatrogenic encephalopathies are not so rare in psychiatry: A retrospective study about 5217 EEG examinations Neurophysiol. Clin. (IF 3.0) Pub Date : 2023-08-31 Manuel Dias Alves, Jean Vion-Dury
Objectives Encephalopathy is a severe pathological process induced by multiple factors, which is typically associated with electroencephalogram (EEG) abnormalities. Early diagnosis, management, and treatment improve the patient's prognosis. Psychotropic treatments are a risk for drug-induced encephalopathies. In this study, the prevalence of encephalopathies in a psychiatric hospital has been studied
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Neural symphony of risky decision making in children with ADHD: Insights from transcranial alternating current stimulation and cognitive modeling Neurophysiol. Clin. (IF 3.0) Pub Date : 2023-08-31 Vahid Nejati, Zahra Famininejad, Jamal Amani Rad
Background The ventromedial prefrontal cortex (vmPFC) and dorsolateral prefrontal cortex (dlPFC) are key brain regions involved in risky decision making, affected in individuals with attention deficit hyperactivity disorder (ADHD). This study aims to examine how entrainment of these areas impacts the process and outcome of risky decision making in children with ADHD. Methods Eighteen children with
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The effects of hypercortisolism on the frequency and magnitude of sleep EEG waves in patients with Cushing syndrome: A spectral analysis study Neurophysiol. Clin. (IF 3.0) Pub Date : 2023-08-30 Duygu Kurt Gok, Sevda İsmailogullari, Ramazan Aldemir, Mahmut Tokmakci, Sedat Tarik Firat, Zuleyha Karaca, Fahrettin Kelestimur, Gokmen Zararsiz
Objectives Our aim was to investigate the effects of endogenous chronic hypercortisolism on sleep electroencephalogram (EEG) and differences between the adrenocorticotropic hormone (ACTH)-dependent and independent Cushing Syndrome (CS) patients through a sleep spectral analysis program. Methods A total of 32 patients diagnosed as having endogenous CS (12 ACTH-dependent and 20 ACTH-independent) and
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Offline 20 Hz transcranial alternating current stimulation over the right inferior frontal gyrus increases theta activity during a motor response inhibition task Neurophysiol. Clin. (IF 3.0) Pub Date : 2023-06-22 Ekaterina Lyzhko, Stefanie E. Peter, Frauke Nees, Michael Siniatchkin, Vera Moliadze
Objectives Previous studies have shown that the right inferior frontal gyrus (rIFG) and the pre-supplementary motor area (preSMA) play an important role in motor inhibitory control. The aim of the study was to use theta frequency transcranial alternating current stimulation (tACS) to modulate brain activity in the rIFG and preSMA and to test the effects of stimulation using a motor response inhibition
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Effects of the TENS device, Exopulse Mollii Suit, on pain related to fibromyalgia: An open-label study Neurophysiol. Clin. (IF 3.0) Pub Date : 2023-05-23 Naji Riachi, Moussa A. Chalah, Rechdi Ahdab, Feroza Arshad, Samar S. Ayache
Fibromyalgia is characterized by diffuse and chronic pain, that is often only partially alleviated by the available pharmacological treatments. Therefore, nonpharmacological interventions such as transcutaneous electrical stimulation (TENS) are highly needed to improve the quality of life of this population. However, the classical TENS devices offer a limited number of electrodes and are not adapted
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Exploring the split hand phenomenon with the neurophysiological index Neurophysiol. Clin. (IF 3.0) Pub Date : 2023-05-22 Cláudia Santos Silva, Michael Swash, Mamede de Carvalho
In 164 subjects of different age groups, we studied the neurophysiological index (NI) ([CMAP amplitude/Distal motor latency] *[F-wave frequency]; CMAP=compound muscle action potential) for three hand muscles (APB= abductor pollicis brevis; FDI= first dorsal interosseous; ADM= abductor digiti minimi). A split hand index based on CMAP amplitude (SHI_CMAP) and NI (SHI_NI) were calculated ([APB CMAP amplitude
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Neuromuscular fatigue in autoimmune myasthenia gravis: A cross-sectional study Neurophysiol. Clin. (IF 3.0) Pub Date : 2023-02-22 Simone Birnbaum, Tarek Sharshar, Jacques Ropers, Pierre Portero, Jean-Yves Hogrel
Objectives To investigate the presence of increased neuromuscular fatigue (NMF) in individuals with myasthenia gravis (IwMG), compared to healthy controls. A secondary aim was to assess associations between NMF, strength and perceived health-related quality of life (HRQoL) and symptom severity in IwMG. Methods In this cross-sectional study, we assessed NMF using classical myoelectrical indicators (root
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The cutaneous silent period as a measure of upper motor neuron dysfunction in amyotrophic lateral sclerosis Neurophysiol. Clin. (IF 3.0) Pub Date : 2023-01-29 José Castro, Michael Swash, Mamede de Carvalho
Objectives We investigated the cutaneous silent period (CutSP) as a measure of upper motor neuron (UMN) dysfunction in amyotrophic lateral sclerosis. Methods The onset latency, duration, and amount of EMG suppression of the CutSP were compared with clinical UMN signs in 24 patients with amyotrophic lateral sclerosis (ALS). UMN signs were quantified using a clinical index and transcranial magnetic stimulation
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Patients with neuropathic pain from lumbosacral radiculopathy demonstrate similar pressure pain thresholds and conditioned pain modulation to those with fibromyalgia Neurophysiol. Clin. (IF 3.0) Pub Date : 2023-01-28 Aleksandar Knezevic, Milena Kovacevic, Milica Jeremic-Knezevic, Zeljka Nikolasevic, Snezana Tomasevic-Todorovic, Zeljko Zivanovic, Tijana Spasojevic, Enis Garipi, Larisa Vojnovic, Dunja Popovic, Randy Neblett
Objective The purpose of the study was to evaluate pain thresholds, impairment of the endogenous pain modulatory system, and self-reported cognitive-emotional and central sensitization-related symptoms among three subject groups: a rarely studied patient cohort with neuropathic pain from lumbosacral radiculopathy (NPLSR), patients with fibromyalgia (FM) and healthy controls (HC). Methods Patient-reported
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Altered central pain processing assessed by quantitative sensory testing in patients with failed back surgery syndrome Neurophysiol. Clin. (IF 3.0) Pub Date : 2022-11-19 Cong Nie, Kaiwen Chen, Jie Chen, Yu Zhu, Jianyuan Jiang, Xiang Jin, Xinlei Xia, Chaojun Zheng
Objective To investigate the presence of altered central pain processing in patients with failed back surgery syndrome (FBSS) using quantitative sensory testing (QST). Methods This study included 34 patients with FBSS, 102 patients post-lumbar surgery without low back pain (LBP), and 102 healthy subjects. All subjects underwent both pressure pain threshold (PPT) and conditioned pain modulation (CPM)
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The duration of successive epileptic seizures is monotonically correlated in neonates Neurophysiol. Clin. (IF 3.0) Pub Date : 2022-11-10 Francesco Pisani, Rosario Statello, Giuseppe Pedrazzi, Michele Miragoli, Benedetta Piccolo, Emanuela Claudia Turco
Objective Prolonged neonatal seizures are often due to severe acute brain injuries and are known to be harmful to the brain. No predictors have yet been identified to distinguish at an early time-point between brief and long seizures. We investigated the duration of seizures in neonates to determine the relationship between the duration of a seizure and that of subsequent seizures. Methods We retrospectively
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Hyperconnectivity matters in early-onset Alzheimer's disease: a resting-state EEG connectivity study Neurophysiol. Clin. (IF 3.0) Pub Date : 2022-11-10 Ezgi Fide, Duygu Hünerli-Gündüz, İbrahim Öztura, Görsev G. Yener
Objectives The aim of this study was to differentiate individuals with early-onset Alzheimer's disease (EOAD) and identify differences of functional connectivity in resting-state EEG between individuals with EOAD and late-onset AD (LOAD) in comparison with both healthy young and elderly individuals. Methods Forty EOAD and 56 LOAD patients were included along with 51 demographically matched young, and
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Motor event-related synchronization as an inhibitory biomarker of pain severity, sensitivity, and chronicity in patients with knee osteoarthritis Neurophysiol. Clin. (IF 3.0) Pub Date : 2022-11-05 Lucas M. Marques, Sara P. Barbosa, Kevin Pacheco-Barrios, Fernanda T. Goncalves, Marta Imamura, Linamara R. Battistella, Marcel Simis, Felipe Fregni
Objective The study aimed to examine the clinical and neurophysiological predictors of motor event-related desynchronization (ERD) and synchronization (ERS) in patients with chronic pain due to knee osteoarthritis (KOA). Methods We performed a cross-sectional analysis of our cohort study (DEFINE cohort), KOA arm, with 71 patients, including demographic, functionality, genetic and neurophysiological
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Sympathetic skin response as an objective tool to estimate stimulus-associated arousal in a human model of hyperalgesia Neurophysiol. Clin. (IF 3.0) Pub Date : 2022-10-26 Charbel Salameh, Caroline Perchet, Koichi Hagiwara, Luis Garcia-Larrea
Background Pain is a private experience, whose assessment relies on subjective self-reporting. Inaccurate communication renders pain evaluation unreliable in individuals with alteration of consciousness, lack of verbal interaction, cognitive dysfunction or simple malingering, hence the importance of developing reliable objective assessment tools. Objectives Since pain is associated with autonomic arousal
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Electroencephalographic evolution of SEEG-associated intracerebral haemorrhage Neurophysiol. Clin. (IF 3.0) Pub Date : 2022-10-22 Marai Mozhy Mahizhnan, Lisa Gillinder, Donald Craig, Isaac Wensley, Stephen Coyle, Stuart Ferguson, Jason Papacostas, Aileen McGonigal
Abstract not available
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Young infants with PMP22 duplication can have minor nerve conduction study abnormalities Neurophysiol. Clin. (IF 3.0) Pub Date : 2022-10-15 Jean-Baptiste Davion, François Cassim, Yann Péréon, Sylvie Nguyen The Tich
Charcot-Marie-Tooth disease type 1A (CMT1A) is related to PMP22 gene duplication. It is characterized at electrodiagnostic testing (EDX) by diffuse homogeneous signs of demyelination, such as velocity slowing and prolonged distal latencies. These abnormalities are less pronounced in infants under two years old, and the possibility of normal nerve conduction studies (NCS) in infants with CMT1A under
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Attention bias modification through transcranial direct current stimulation (tDCS): A review Neurophysiol. Clin. (IF 3.0) Pub Date : 2022-10-12 Vahid Nejati, Raheleh Heyrani, Michael Nitsche
Attention bias is a tendency to preferably detect, orient and select emotionally valued stimuli, as compared to neutral stimuli, and plays a crucial role in the psychopathology of various psychiatric disorders. Transcranial direct current stimulation (tDCS) has been applied for the alteration of attention bias in health and disease with different parameters and conditions, but the contribution of these
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The influence of kinesiophobia and pain catastrophizing on pain-induced corticomotor modulation in healthy participants: A cross sectional study Neurophysiol. Clin. (IF 3.0) Pub Date : 2022-10-08 Arnaud Duport, René Pelletier, Marylie Martel, Guillaume Léonard
Objectives Several studies suggest that acute pain decreases corticomotor excitability. However, the variability between patients remains important and unexplained. The aim of this study was to unveil potential sources of variation by looking at the effect of kinesiophobia and pain catastrophizing on pain-induced corticomotor modulation. Methods Corticomotor excitability was assessed with the slopes
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Etiology matters for neuroprognostication: A multimodal electrophysiological investigation in a case of Bickerstaff's brainstem encephalitis Neurophysiol. Clin. (IF 3.0) Pub Date : 2022-10-07 Florent Cluse, Antoine Pegat, Thomas Ritzenthaler, Florent Gobert, Julien Jung
We report the case of a 19-year-old patient with an acute-onset non-traumatic coma. Brain MRI scan was normal, CSF showed mild pleocytosis and moderately elevated protein, and continuous EEG-monitoring was compatible with spindle-coma. Cortical somatosensory evoked potentials (SSEPs) and middle-latency auditory evoked potentials (MLAEPs) were bilaterally absent, and brainstem auditory evoked potentials
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Improvement in small fiber neuropathy after a gluten-free diet, demonstrated in a patient with celiac disease by measurement of electrochemical skin conductance Neurophysiol. Clin. (IF 3.0) Pub Date : 2022-10-07 Anand Hinduja, Marie-Laure Nevoret, Jean-Henri Calvet
Abstract not available
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Repetitive transcranial magnetic stimulation of the human motor cortex in the gamma band reduces cortical excitability Neurophysiol. Clin. (IF 3.0) Pub Date : 2022-10-06 Artemis Traikapi, Phivos Phylactou, Nikos Konstantinou
Abstract not available
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Erratum to ‘The N13 spinal component of somatosensory evoked potentials is modulated by heterotopic noxious conditioning stimulation suggesting an involvement of spinal wide dynamic range neurons’ Neurophysiol. Clin. (IF 3.0) Pub Date : 2022-10-06 Giuseppe Di Pietro, Giulia Di Stefano, Caterina Leone, Andrea Di Lionardo, Emanuele Sgro, Anthony James Blockeel, Ombretta Caspani, Luis Garcia-Larrea, André Mouraux, Keith Geoffrey Phillips, Rolf-Detlef Treede, Massimiliano Valeriani, Andrea Truini
Abstract not available
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Stereological and electrophysiological evaluation of autonomic involvement in amyotrophic lateral sclerosis Neurophysiol. Clin. (IF 3.0) Pub Date : 2022-09-23 Rustem Ozturk, Pall Karlsson, Xiaoli Hu, Esra Akdeniz, Selcuk Surucu, Baris Isak
Objective Previous studies have identified autonomic dysfunction in amyotrophic lateral sclerosis (ALS) using mostly neurophysiological techniques. In this study, stereological evaluation of autonomic fibers and sweat glands has been performed to identify structural evidence of autonomic denervation in patients with ALS. Methods In this study, 29 ALS patients were compared to 29 controls using COMPASS-31
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EEG reading with or without clinical information – a real-world practice study Neurophysiol. Clin. (IF 3.0) Pub Date : 2022-09-17 Fábio A. Nascimento, Jin Jing, Sándor Beniczky, Marcia Olandoski, Selim R. Benbadis, Andrew J. Cole, M. Brandon Westover
We sought to investigate electroencephalographers’ real-world behaviors and opinions concerning reading routine EEG (rEEG) with or without clinical information. An eight-question, anonymous, online survey targeted at electroencephalographers was disseminated on social media from the authors’ personal accounts and emailed to authors’ select colleagues. A total of 389 responses were included. Most respondents
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