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Extended-release amantadine for OFF-related dystonia in Parkinson's disease Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-03-04 Alberto J. Espay, Jill L. Ostrem, Andrea E. Formella, Caroline M. Tanner
Dystonia is a painful OFF-related complication in Parkinson's disease (PD) with limited treatment options. analysis using pooled data from two extended-release amantadine pivotal trials and follow-on open-label extension. Dystonia was assessed using the Unified Dyskinesia Rating Scale (UDysRS) Part 2 and the Movement Disorder Society-Unified PD Rating Scale (MDS-UPDRS) item 4.6. Of 196 participants
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Loss of monomeric alpha-synuclein (synucleinopenia) and the origin of Parkinson's disease Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-03-03 Alberto J. Espay, Andrew J. Lees
These facts argue against the gain-of-function synucleinopathy hypothesis, which proposes that Lewy pathology causes Parkinson's disease: (1) most brains from people without neurological symptoms have multiple pathologies; (2) neither pathology type nor distribution correlate with disease severity or progression in Parkinson's disease; (3) aggregated α-synuclein in the form of Lewy bodies is not a
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The cingulate island sign in a mixed memory clinical cohort: Prevalence and diagnostic accuracy Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-03-02 Linda Ruohua Feng, Gunhild Waldemar, Steen Gregers Hasselbalch, Asmus Vogel, Otto Mølby Henriksen, Ian Law, Kristian Steen Frederiksen
Visual rating of the cingulate island sign (CIS) on [F]fluorodeoxyglucose ([F]FDG) positron emission tomography (PET) has a high specificity for dementia with Lewy bodies (DLB) in selected cohorts such as DLB versus Alzheimer's disease (AD). In a mixed memory clinical population this study aimed to uncover the prevalence of CIS, the diagnostic accuracy for DLB, and the relationship between CIS and
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Mood disturbances in newly diagnosed Parkinson's Disease patients reflect intrathecal inflammation Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-28 Mario Stampanoni Bassi, Luana Gilio, Giovanni Galifi, Fabio Buttari, Ettore Dolcetti, Antonio Bruno, Lorena Belli, Nicola Modugno, Roberto Furlan, Annamaria Finardi, Georgia Mandolesi, Alessandra Musella, Diego Centonze, Enrica Olivola
In Parkinson's disease (PD), neuroinflammation may be involved in the pathogenesis of mood disorders, contributing to the clinical heterogeneity of the disease.
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Post-COVID parkinsonism: A scoping review Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-28 Paola Polverino, Antoniangela Cocco, Alberto Albanese
The clinical features and outcomes of post-COVID parkinsonism have not been organized systematically, and the possible correlations between COVID-19 and parkinsonism have not been elucidated. This scoping review addresses these two unmet needs. We searched two databases (Pubmed, Embase) for all published cases of post-COVID parkinsonism. Data were extracted from eligible studies using standardized
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Melanopsin retinal ganglion cell function in Alzheimer's vs. Parkinson's disease an exploratory meta-analysis and review of pupillometry protocols Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-27 Oliver Leopold Steiner, Jan de Zeeuw
Neurodegenerative diseases share retinal abnormalities. Chromatic pupillometry allows assessment of photoreceptor functional integrity, including melanopsin-expressing retinal ganglion cells. This exploratory meta-analysis assesses retinal photoreceptor functionality in Alzheimer's vs. Parkinson's disease and conducts an in-depth review of applied pupillometric protocols. Literature reviews on PubMed
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Mapping brain metabolism, connectivity and neurotransmitters topography in early and late onset dementia with lewy bodies Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-27 Silvia Paola Caminiti, Alice Galli, Lorenzo Jonghi-Lavarini, Cecilia Boccalini, Nicolas Nicastro, Arturo Chiti, Valentina Garibotto, Daniela Perani
Early-onset dementia with Lewy bodies (EO-DLB) is associated with rapid cognitive decline and severe neuropsychiatric symptoms at onset. Using FDG-PET imaging for 62 patients (21 EO-DLB, 41 LO (late-onset)-DLB), we explored brain hypometabolism, and metabolic connectivity in the whole-brain network and resting-state networks (RSNs). We also evaluated the spatial association between brain hypometabolism
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Longitudinal brain changes in Parkinson's disease with severe olfactory deficit Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-27 Kazuya Kawabata, Epifanio Bagarinao, Klaus Seppi, Werner Poewe
Olfactory dysfunction and REM sleep behavior disorder (RBD) are associated with distinct cognitive trajectories in the course of Parkinson's disease (PD). The underlying neurobiology for this relationship remains unclear but may involve distinct patterns of neurodegeneration. This study aimed to examine longitudinal cortical atrophy and thinning in early-stage PD with severe olfactory deficit (anosmia)
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Exploring obstructive sleep apnea and sleep architecture in Parkinson's disease motor subtypes Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-23 Amanda Scanga, Andrea Benedetti, R John Kimoff, Anne-Louise Lafontaine, Ann Robinson, Marianne Gingras, Marta Kaminska
Parkinson's disease (PD) can be divided into motor subtypes: postural instability/gait difficulty (PIGD), tremor dominant, and indeterminate. This study aimed to assess differences in sleep structure and obstructive sleep apnea (OSA) between the PIGD and non-PIGD subtypes. PD participants with or without OSA (defined as apnea-hypopnea index (AHI) ≥ 15 events/hour on overnight polysomnography) were
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“Advanced” Parkinson's disease: A review Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-23 Sana Aslam, Fredric Manfredsson, Ashley Stokes, Holly Shill
There is no consensus driven definition of “advanced” Parkinson's disease (APD) currently. APD has been described in terms of emergence of specific clinical features and clinical milestones of the disease e.g., motor fluctuations, time to increasing falls, emergence of cognitive decline, etc. The pathological burden of disease has been used to characterize various stages of the disease. Imaging markers
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Getting an earful of stimulation: A novel means for neuromodulation of Parkinson disease Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-20 Peter A. LeWitt
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Genetic testing for non-parkinsonian movement disorders: Navigating the diagnostic maze Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-17 Cholpon Shambetova, Christine Klein
Genetic testing has become a valuable diagnostic tool for movement disorders due to substantial advancements in understanding their genetic basis. However, the heterogeneity of movement disorders poses a significant challenge, with many genes implicated in different subtypes. This paper aims to provide a neurologist's perspective on approaching patients with hereditary hyperkinetic disorders with a
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Exploration of potential immune mechanisms in cervical dystonia Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-17 Laura M. Scorr, Gamze Kilic-Berkmen, Diane J. Sutcliffe, Ashok R. Dinasarapu, J. Lucas McKay, Pritha Bagchi, Michael D. Powell, Jeremy M. Boss, Nezih Cereb, Marian Little, Loren Gragert, John Hanfelt, Andrew McKeon, William Tyor, H.A. Jinnah
Although there are many possible causes for cervical dystonia (CD), a specific etiology cannot be identified in most cases. Prior studies have suggested a relationship between autoimmune disease and some cases of CD, pointing to possible immunological mechanisms. The goal was to explore the potential role of multiple different immunological mechanisms in CD. First, a broad screening test compared neuronal
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Huntington disease – Update on ongoing therapeutic developments and a look toward the future Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-15 Cristina Sampaio
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Cerebellar and thalamic connector hubs facilitate the involvement of visual and cognitive networks in essential tremor Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-14 Epifanio Bagarinao, Satoshi Maesawa, Sachiko Kato, Manabu Mutoh, Yoshiki Ito, Tomotaka Ishizaki, Takafumi Tanei, Takashi Tsuboi, Masashi Suzuki, Hirohisa Watanabe, Minoru Hoshiyama, Haruo Isoda, Masahisa Katsuno, Gen Sobue, Ryuta Saito
Connector hubs are specialized brain regions that connect multiple brain networks and therefore have the potential to affect the functions of multiple systems. This study aims to examine the involvement of connector hub regions in essential tremor. We examined whole-brain functional connectivity alterations across multiple brain networks in 27 patients with essential tremor and 27 age- and sex-matched
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Can striatal dopamine transporter uptake increase following CSF tap test in patients with idiopathic normal pressure hydrocephalus? Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-13 Minju Kim, Young Ho Park, Yoo Sung Song, Kyunghun Kang, SangYun Kim
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GBA1-and LRRK2-directed treatments: The way forward Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-13 Gadi Maayan Eshed, Roy N. Alcalay
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Recent advances in non-Huntington's disease choreas Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-13 Molly C. Cincotta, Ruth H. Walker
Chorea is primarily due to an imbalance of basal ganglia output pathways, often due to dysfunction or degeneration of the caudate nucleus and putamen, and can be due to many causes. We reviewed the recent literature to identify newly-recognized causes of chorea, including auto-immune, metabolic, and genetic. We also focused upon developments in mechanisms relating to underlying pathophysiology of certain
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Statin therapy in Parkinson's disease cuts mortality Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-13 Josef Finsterer, Antonio-Carlos G. de Almeida, Feres Chaddad-Neto, Fulvio A. Scorza
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Novel RAB39B loss-of-function mutation in patient with typical early-onset Parkinson's disease Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-13 Jessie R. Jacobson, Capucine Piat, Allen J. Aksamit, Gaia Patane, Owen Ross, Rodolfo Savica
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Thyroid disease in cervical dystonia- is the coexistence of thyroid diseases and cervical dystonia a coincidence? Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-13 Esra Koçhan Kızılkılıç, Nursena Erener, Mustafa Meriç, Nurten Uzun Adatepe, Ayşegül Gündüz
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Putaminal T1/T2-weighted ratio is increased in PSP compared to PD and healthy controls, a multi-cohort study Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-13 Henrik Sjöström, Danielle van Westen, Sara Hall, Jonathan Tjerkaski, Eric Westman, Sebastian Muehlboeck, Oskar Hansson, Per Svenningsson, Tobias Granberg
Differentiating Parkinson's disease (PD) from progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) is a common clinical problem. We aimed to apply the T-/T-weighted ratio imaging technique, based on standard clinical MRI, to reveal differences in neurodegeneration in three large cohorts. Three cohorts, with a total of 405 participants (269 PD, 44 PSP, 38 MSA, 54 controls), were combined
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MR-guided focused ultrasound in movement disorders and beyond: Lessons learned and new frontiers Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-12 Elena Natera-Villalba, María-Agustina Ruiz-Yanzi, Carmen Gasca-Salas, Michele Matarazzo, Raúl Martínez-Fernández
The development of MR-guided focused ultrasound (MRgFUS) has provided a new therapeutic tool for neuropsychiatric disorders. In contrast to previously available neurosurgical techniques, MRgFUS allows precise impact on deep brain structures without the need for incision and yields an immediate effect. In its high-intensity modality (MRgHIFU), it produces accurate therapeutic thermoablation in previously
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Associations of sleep-related variables with reverse dipping patterns of blood pressure in α-synucleinopathies Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-12 Yunchuang Sun, Luhua Wei, Fan Li, Chen Ling, Fei Zhai, Yunfeng Lv, Hong Zhou, Cheng Zhang, Jing Ma, Jing Chen, Wei Sun, Zhaoxia Wang
The reverse dipping blood pressure (BP) pattern is very common in αsynucleinopathies. We aimed to explore the associations of sleep-related variables with abnormal BP circadian rhythms in Parkinson's disease (PD) and multiple system atrophy (MSA). A total of 126 patients, 76 with PD and 50 with MSA, were included. All participants underwent ambulatory BP monitoring and full-night polysomnography (PSG)
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Forced-choice lavender discrimination in Parkinson's disease Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-12 Donald L. Bliwise, Lynn Marie Trotti
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Suicide attempt in a dopamine agonist withdrawal syndrome in Parkinson's disease Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-12 Melisa Espindola, Natalia González Rojas, Giselle Vaisentein, Gustavo Da Prat, Martin Cesarini, Jose Luis Etcheverry, Emilia M. Gatto
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Determining the impact of specialized care on health outcomes and health care utilization in Parkinsonism Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-11 Conrad J. Goerz, Anish Kanungo, Lisa M. Lix, William D. Leslie, Charles Burchill, Douglas E. Hobson
Although care of Parkinsonism (PKM) is assumed to be optimally provided by movement disorder neurologists within an interdisciplinary clinic model, there is a paucity of published data to support this. To investigate the impact of movement disorder neurologist care of individuals with Parkinsonism (PKM). A retrospective exposure design was adopted using administrative data. Incident PKM individuals
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Hope vs. Hype I: Spreading alpha-synuclein explains cognitive deficits in Parkinson disease Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-11 Kelly A. Mills, Oliver Phillips, Abhimanyu Mahajan
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Parkinson's disease patients with absence of normal dipping status were more vulnerable to cognitive impairment from the early stages Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-10 Lanlan Chen, Li Jiang, Chenxin Wang, Tingting Qiao, Cancan Ma, Yingzhu Chen, Chunfeng Liu, Xin Wang, Yao Xu
The objective of this study was to determine the characteristics of cognitive function in Parkinson's disease (PD) patients with different dipping statuses. Consecutive PD patients were recruited for this study. All participants underwent 24-h ambulatory blood pressure monitor (ABPM). Corresponding scales were employed to evaluate both motor and non-motor symptoms. The subjects were categorized into
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Short-latency afferent inhibition as a biomarker of cholinergic degeneration compared to PET imaging in Parkinson's disease Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-10 Emile d’Angremont, Iris E.C. Sommer, Sygrid van der Zee, Teus van Laar, Erik F.J. de Vries, Inge Zijdewind
Short-latency afferent inhibition (SAI) is a relatively cheap and non-invasive method that has been proposed as a cholinergic marker in Parkinson's disease (PD). We aim to verify the clinical feasibility of SAI as a cholinergic marker in PD using positron emission tomography (PET) with the tracer ()-5-(2-[F]fluoroethoxy)benzovesamicol ([F]FEOBV) as a reference. We examined relations between SAI and
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Striato-cortical functional connectivity changes in mild cognitive impairment with Lewy bodies Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-10 Lubomira Novakova, Martin Gajdos, Marek Barton, Lubos Brabenec, Zaneta Zeleznikova, Ivona Moravkova, Irena Rektorova
Functional connectivity changes in clinically overt neurodegenerative diseases such as dementia with Lewy bodies have been described, but studies on connectivity changes in the pre-dementia phase are scarce. We concentrated on evaluating striato-cortical functional connectivity differences between patients with Mild Cognitive Impairment with Lewy bodies and healthy controls and on assessing the relation
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Group tele-rehabilitation improves quality of life among subjects with Parkinson's disease: A two arm non-parallel non-randomized clinical trial Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-10 Nidhi Sharma, Ankita Yadav, Manpreet Kaur, Parveen Kumar, Simranjeet Kaur, Gaurav Kapoor, Meenu Verma
Tele-rehabilitation has lately emerged as a promising medium for increasing patient adherence with significant positive results. One of the most prevalent neurological diseases affecting movement is Parkinson's disease (PD), which causes a variety of motor and non-motor symptoms among patients. Consequentially, the study was designed to compare the efficacy of group tele-rehabilitation with individual
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Refining the clinical diagnosis of Parkinson's disease Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-10 Eoin Mulroy, Roberto Erro, Kailash P. Bhatia, Mark Hallett
Our ability to define, understand, and classify Parkinson's disease (PD) has undergone significant changes since the disorder was first described in 1817. Clinical features and neuropathologic signatures can now be supplemented by in-vivo interrogation of genetic and biological substrates of disease, offering great opportunity for further refining the diagnosis of PD.
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Parkinson's disease progression is multifaceted: Evidence for the underlying benchmarks Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-10 J. Eric Ahlskog
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Abnormal supplementary motor areas are associated with idiopathic and acquired blepharospasm Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-09 Jinping Xu, Xiaodong Zhang, Qinxiu Cheng, Haoran Zhang, Linchang Zhong, Yuhan Luo, Yue Zhang, Zilin Ou, Zhicong Yan, Kangqiang Peng, Gang Liu
Blepharospasm is a common form of focal dystonia characterized by excessive and involuntary spasms of the orbicularis oculi. In addition to idiopathic blepharospasm, lesions in various brain regions can also cause acquired blepharospasm. Whether these two types of blepharospasm share a common brain network remains largely unknown. Herein, we performed lesion coactivation network mapping, based on meta-analytic
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Association of bilateral oophorectomy with incidence of Parkinson's disease: A systematic review and meta-analysis Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-09 Abraish Ali, Syeda Areeba Tabassum, Zuhaa Rehman, Mahek Ramani, Khadija Ali, Ahmed Mustafa Siddiqui, Umer Shahid, Usama Sakrani, Hania Samhan, Syeda Sabahat, Shayan Marsia
Current evidence in the literature is inconclusive due to conflicting results with regards to an association between B/L (B/L) oophorectomy and Parkinson's disease (PD). We included large, powered studies to assess the association of PD in women who have undergone B/L oophorectomy. We conducted a comprehensive search across three databases from inception to October 2022 for observational studies including
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Decreased brain volume may be associated with the occurrence of peri-lead edema in Parkinson's disease patients with deep brain stimulation Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-09 Marina Raguž, Petar Marčinković, Hana Chudy, Darko Orešković, Marin Lakić, Domagoj Dlaka, Nataša Katavić, Valentino Rački, Vladimira Vuletić, Darko Chudy
Peri-lead edema (PLE) is a poorly understood complication of deep brain stimulation (DBS), which has been described in patients presenting occasionally with profound and often delayed symptoms with an incidence ranging from 0.4% up to even 100%. Therefore, our study aims to investigate the association of brain and brain compartment volumes on magnetic resonance imaging (MRI) with the occurrence of
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Using the neurological health of former professional American football players to transform primary care Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-08 Jay L. Alberts
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Childhood-onset writer's cramp, with later ataxia: A clue to COQ8A-related disorders Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-07 Christopher D. Stephen
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Patterns of regional cerebral hypoperfusion in early Parkinson's disease: Clinical implications Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-02 Seok Jong Chung, Su Hong Kim, Chan Wook Park, Hye Sun Lee, Mijin Yun, Yun Joong Kim, Young H. Sohn, Yong Jeong, Phil Hyu Lee
This study aimed to investigate whether regional cerebral perfusion patterns on early-phase F-FP-CIT PET scans, which is typically coupled to cerebral metabolism, predict the long-term prognosis of Parkinson's disease (PD). We enrolled 397 drug-naïve patients with early-stage PD who underwent dual-phase F-FP-CIT PET scans. After quantifying the early-phase F-FP-CIT PET images, cluster analysis was
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Racial disparities in hospitalization characteristics among Native Hawaiians, Pacific Islanders and Asian American subgroups with Parkinson's disease Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-02 Michiko Kimura Bruno, Masako Matsunaga, Emma Krening, Kazuma Nakagawa, John J. Chen, Todd Seto, Fay Gao, Caroline Tanner, G. Webster Ross
Differences among Native Hawaiians/Pacific Islanders (NHPI) and Asian American (AA) subgroups have not been adequately studied in Parkinson's disease (PD). To determine differences in demographics, comorbidities, and healthcare utilization among NHPI, AA subgroups, and White hospitalized PD patients. We conducted a retrospective cross-sectional analysis of Hawaiʻis statewide registry (2016–2020). Patients
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Current practices of burst vs. spaced physical therapy applied to Parkinson's disease Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-02 Jennifer H. LeLaurin, Ramzi G. Salloum, Michael S. Okun
Abstract not available
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Focused ultrasound therapy: Back to the future Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-02 Leo Verhagen Metman, Mariana H.G. Monje, José A. Obeso, Raúl Martínez-Fernández
Abstract not available
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Connectome-based predictive modelling estimates individual cognitive status in Parkinson's disease Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-01 Alexander Tobias Ysbæk-Nielsen
The progressive nature of Parkinson's disease (PD) affords emphasis on accurate early-stage individual-level assessment of risk and intervention appropriateness. In PD, cognitive impairment (CI) may follow or precede motor symptoms but are generally underdetected. In addition to impeding daily functioning and quality of life, CIs increase the risk for later conversion to dementia, providing a pressing
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Support needs of people with Multiple System Atrophy Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-01 Julia LY. Cheong, Zhao HK. Goh, Anette Schrag
Multiple system atrophy (MSA) is a neurodegenerative disease causing parkinsonism, autonomic disturbances, gait impairment and mood disorders. The progressive nature of MSA results in a significant deterioration in quality of life for patients. To investigate the needs of people with MSA (PwMSA) in the United Kingdom (UK) and the support available to them. A survey of members of the UK's MSA Trust
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The missing piece of the puzzle – The key role of the dietitian in the management of Parkinson's disease Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-01 Richelle Flanagan, Carley Rusch, Fiona E. Lithander, Indu Subramanian
The current paradigm for the multidisciplinary management of Parkinson's Disease (PD) does not include regular nutritional assessment despite research showing that 90 % of people living with Parkinson's (PwP) lack access to basic dietetic services. Since many non-motor symptoms such as dysphagia, constipation and orthostatic hypotension and PD complications such as weight loss and sarcopenia can be
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The MemTrax memory test for detecting and assessing cognitive impairment in Parkinson's disease Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-02-01 Yanmei Liu, Lei Wu, Weineng Chen, Fengjuan Su, Ganqiang Liu, Xianbo Zhou, Curtis B. Ashford, Feng Li, J. Wesson Ashford, Zhong Pei, Wenbiao Xian
A valid, reliable, accessible measurement for the early detection of cognitive decline in patients with Parkinson's disease (PD) is in urgent demand. The objective of the study is to assess the clinical utility of the MemTrax Memory Test in detecting cognitive impairment in patients with PD. The MemTrax, a fast on-line cognitive screening tool based on continuous recognition task, and Montreal Cognitive
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Validation study of the Japanese version of the King's Parkinson's Disease Pain Scale and the King's Parkinson's Disease Pain Questionnaire Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-01-28 Kanako Kurihara, Shinsuke Fujioka, Yasuaki Mizutani, Hirohisa Watanabe, Kazuhiro Iwaoka, Tetsuya Maeda, Morinobu Seki, Toshiki Tezuka, Jin Nakahara, Takuya Konno, Takanobu Ishiguro, Osamu Onodera, Yuri Asano, Kazushi Takahashi, Alexandra Rizos, K. Ray Chaudhuri, Yoshio Tsuboi
Introduction The King's Parkinson's Disease Pain Scale (KPPS)/King's Parkinson's Disease Pain Questionnaire (KPPQ) was developed as a tool to quantitatively assess pain in patients with Parkinson's disease (PwPD). Here, we conducted a Japanese multicenter validation study to verify the reliability of KPPS/KPPQ in Japanese PwPD. Methods PwPD, ≥20 years, with unexplained pain were included; those with
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Cervical motion alterations and brain functional connectivity in cervical dystonia Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-01-28 Elisabetta Sarasso, Daniele Emedoli, Andrea Gardoni, Lucia Zenere, Elisa Canu, Silvia Basaia, Alberto Doretti, Nicola Ticozzi, Sandro Iannaccone, Stefano Amadio, Ubaldo Del Carro, Massimo Filippi, Federica Agosta
Introduction Evaluating the neural correlates of sensorimotor control deficits in cervical dystonia (CD) is fundamental to plan the best treatment. This study aims to assess kinematic and resting-state functional connectivity (RS-FC) characteristics in CD patients relative to healthy controls. Methods Seventeen CD patients and 14 age-/sex-matched healthy controls were recruited. Electromagnetic sensors
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Towards therapeutic electrophysiological neurofeedback in Parkinson's disease Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-01-14 Elena Ubeda Matzilevich, Pria Lauren Daniel, Simon Little
Neurofeedback (NF) techniques support individuals to self-regulate specific features of brain activity, which has been shown to impact behavior and potentially ameliorate clinical symptoms. Electrophysiological NF (epNF) may be particularly impactful for patients with Parkinson's disease (PD), as evidence mounts to suggest a central role of pathological neural oscillations underlying symptoms in PD
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Dystonia and parkinsonism: Not an easy combo Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-01-15 Marcela Montiel, Alfonso Fasano
Abstract not available
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Are LRRK2 p.G2019S or GBA1 variants associated with long-term outcomes of deep brain stimulation for Parkinson's disease? Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-01-12 Saar Anis, Tomer Goldberg, Ethan Shvueli, Yuval Kozlov, Yonatan Redlich, Naama Lavi, Inbar Lavie, Yuri Ludwig Sosero, Ziv Gan-Or, Lior Ungar, Zion Zibly, Lior Greenbaum, Tsvia Fay-Karmon, Sharon Hassin-Baer
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The association between plasma GPNMB and Parkinson's disease and multiple system atrophy Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-01-09 Kai Li, Puzhi Wang, Wen Li, Jia-Hui Yan, Yi-Lun Ge, Jin-Ru Zhang, Fen Wang, Cheng-Jie Mao, Chun-Feng Liu
Aims Parkinson's disease (PD), as the second most common neurodegenerative disorder, often presents diagnostic challenges in differentiation from other forms of Parkinsonism. Recent studies have reported an association between plasma glycoprotein nonmetastatic melanoma protein B (pGPNMB) and PD. Methods A retrospective study was conducted, comprising 401 PD patients, 111 multiple system atrophy (MSA)
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The sound of Parkinson's disease: A model of audible bradykinesia Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-01-09 Debbie de Graaf, Rui Araújo, Madou Derksen, Koos Zwinderman, Nienke M. de Vries, Joanna IntHout, Bastiaan R. Bloem
Introduction Evaluation of bradykinesia is based on five motor tasks from the MDS-UPDRS. Visually scoring these motor tasks is subjective, resulting in significant interrater variability. Recent observations suggest that it may be easier to hear the characteristic features of bradykinesia, such as the decrement in sound intensity or force of repetitive movements. The objective is to evaluate whether
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Identifying the prevalence of Parkinson's disease in Denmark using healthcare registries and self-reported survey data Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-01-14 Vicky L. Joshi, Knud Juel, Jette Thuesen, Tina Backmann, Kristian Winge, Lars H. Tang, Ann-Dorthe Zwisler, Tina B. Mikkelsen
Introduction Existing estimates of PD prevalence in Denmark are lower than those in the rest of Europe and are based on identification via single registries. Hence, are aim was to use a combined registry/self-report survey approach to identify people with PD and also investigate whether using different registry methods led to differences in the accuracy, completeness and characteristics of the identified
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Functional ataxia in a specialized ataxia center Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-01-14 Luíza Alves Corazza, Augusto Bragança Reis Rosa, Thiago Yoshinaga Tonholo Silva, Flávio Moura Rezende Filho, Péricles Andrade Maranhão-Filho, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Alberto J. Espay
Background Functional gait is a disorder of ambulation and balance internally inconsistent and incongruent with the phenotypic spectrum of neurological gait disorders. Objectives: This paper aims to clinically characterize patients with functional ataxia. Methods: Patients with functional ataxia were analyzed out of 1350 patients in Ataxia Unit of the Federal University of São Paulo circa 2008 to 2022
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Real or imagined: We need a new scale for psychosis in Parkinson's disease Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-01-11 Gregory M. Pontone, Kelly A. Mills, Roseanne D. Dobkin, Jared T. Hinkle, Melissa J. Nirenberg, Ruth B. Schneider
Abstract not available
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Perceptions of palliative care in Huntington's disease: A qualitative study Parkinsonism Relat. Disord. (IF 4.1) Pub Date : 2024-01-12 B. Heffernan, E. Forbes, L. Seeberger, J. Shattuck, M. Cook, R. Ayele, B.M. Kluger
Introduction Palliative care focuses on improving patient and family quality of life by managing symptoms, psychosocial issues and spiritual concerns. Huntington's disease is a progressive neurodegenerative disorder with no current disease modifying therapy. Although the palliative care model has been postulated to be an integral part of HD care, there are gaps in knowledge about how this care should