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Postictal psychiatric symptoms: A neurophysiological study Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-08 Daniel S. Weisholtz, Alexa Roy, Ava Sanayei, Brannon Cha, Dustine Reich, David A. Silbersweig, Barbara A. Dworetzky
Postictal psychiatric symptoms (PPS) are a relatively common but understudied phenomenon in epilepsy. The mechanisms by which seizures contribute to worsening in psychiatric symptoms are unclear. We aimed to identify PPS prospectively during and after admission to the epilepsy monitoring unit (EMU) in order to characterize the postictal physiologic changes leading to PPS. We prospectively enrolled
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Impact of the COVID-19 pandemic, its related social restriction measures and vaccination campaign on emergency department attendances for epileptic seizures: An interrupted time-series analysis Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-30 Francesco Brigo, Gloria Brigiari, Michael Mian, Gianni Turcato, Serena Sibilio, Arian Zaboli
To investigate the impact of the outbreak of the COVID-19 pandemic, its related social restriction measure (national lockdown) and vaccination campaign on emergency department (ED) accesses for epileptic seizures. Retrospective observational analysis conducted on a consecutive cohort of patients who sought medical care at the ED of the General Hospital of Merano, Italy, from January 1, 2015, to December
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A quantitative cross-sectional study of the burden of caring for patients with Lennox-Gastaut syndrome, Dravet syndrome, and tuberous sclerosis complex-associated epilepsy in Japan Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-30 Michael LoPresti, Ataru Igarashi, Yaoki Sonohara, Sally Bowditch
Lennox-Gastaut syndrome (LGS), Dravet syndrome (DS), and tuberous sclerosis complex (TSC)-associated epilepsy are rare conditions associated with severe childhood-onset epilepsy. Caregivers play a critical role in the patients’ care and may experience significant psychosocial and socioeconomic burden. This cross-sectional study determined the burden of caring for patients with these rare epilepsy conditions
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Long-term characterization of cognitive phenotypes in children with seizures over 36 months Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-29 Jordan Eisner, Danielle Harvey, David Dunn, Jana Jones, Anna Byars, Philip Fastenau, Joan Austin, Bruce Hermann, Temitayo Oyegbile-Chidi
Children with new-onset epilepsies often exhibit co-morbidities including cognitive dysfunction, which adversely affects academic performance. Application of unsupervised machine learning techniques has demonstrated the presence of discrete cognitive phenotypes at or near the time of diagnosis, but there is limited knowledge of their longitudinal trajectories. Here we investigate longitudinally the
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The effects of web-based animation-supported progressive relaxation exercises applied to individuals with epilepsy on fatigue and sleep quality: A randomized controlled study Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-29 Neşe İşcan Ayyildiz, Nuray Bingöl
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The relationship between medication adherence and complementary medicine use in epilepsy patients Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-28 Fatma Gündüz Oruç, Gülden Atan, Demet Şeker
The aim of this research is to examine the usage of Complementary and Integrated Medicine (CIM) in individuals with epilepsy and the impact of CIM usage on medication adherence. This descriptive and cross-sectional study was conducted in a university hospital in northern Turkey between July and October 2023, involving 101 individuals with epilepsy (PWE). Descriptive information forms and the Morisky
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Association between serum apolipoprotein E and cognitive function in Chinese patients with temporal lobe epilepsy Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-28 Yuwei Han, Guangzhi Hao, Zhen Wang, Chenchen Wang, Xin Qi, Guobiao Liang, Xiaoming Li
To investigate the effect of serum apolipoprotein E (APOE) levels on cognitive function in patients with temporal lobe epilepsy (TLE). Clinical data were collected from 190 subjects including 110 TLE patients and 80 healthy people. Cognitive function was assessed using the Addenbrooke’s Cognitive Examination Revised (ACE-R) scale. Serum levels of APOE were measured using ELISA kits. Genotyping of APOE
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Psychiatric and behavioral concerns of perampanel with concomitant levetiracetam in children with epilepsy Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-27 Jon Soo Kim, Won Seop Kim, Won Young Sung, Hyewon Woo
Perampanel (PER) is expanding the therapeutic scope for pediatric epilepsy owing to its efficacy and favorable safety profile. However, concerns about psychiatric and behavioral adverse events (PBAEs) in combination therapy with levetiracetam (LEV) continue to contribute to hesitation in its prescription. We investigated the risk profiles for PBAEs when adding PER to pediatric epilepsy treatment and
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Deep learning approaches for seizure video analysis: A review Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-23 David Ahmedt-Aristizabal, Mohammad Ali Armin, Zeeshan Hayder, Norberto Garcia-Cairasco, Lars Petersson, Clinton Fookes, Simon Denman, Aileen McGonigal
Seizure events can manifest as transient disruptions in the control of movements which may be organized in distinct behavioral sequences, accompanied or not by other observable features such as altered facial expressions. The analysis of these clinical signs, referred to as semiology, is subject to observer variations when specialists evaluate video-recorded events in the clinical setting. To enhance
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Breathing control training for functional seizures: A multi-site, open-label pilot study Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-22 Roderick Duncan, David J Berlowitz, Saul Mullen, Janet Bondarenko, Toby T Winton-Brown, Terence J O'Brien, Sophie Zaloumis, Sabine Braat, Georgina Oliver, Richard A Kanaan
There are no well-validated treatments for functional seizures. While specialist psychotherapy is usually recommended, the evidence for its benefit is qualified, and it can be difficult to obtain. Given the association between hyperventilation and functional seizures we explored an alternative modality, breathing control training, in a multi-site open label pilot trial. Participants with functional
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PCDH19-clustering epilepsy, pathophysiology and clinical significance Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-22 Safoura Kowkabi, Majid Yavarian, Reza Kaboodkhani, Mahmood Mohammadi, Reza Shervin Badv
PCDH19 clustering epilepsy (PCDH19-CE) is an X-linked epilepsy disorder associated with intellectual disability (ID) and behavioral disturbances, which is caused by PCDH19 gene variants. PCDH19 pathogenic variant leads to epilepsy in heterozygous females, not in hemizygous males and the inheritance pattern is unusual. The hypothesis of cellular interference was described as a key pathogenic mechanism
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The promise of AI Large Language Models for Epilepsy care Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-21 Raphaëlle Landais, Mustafa Sultan, Rhys H Thomas
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Estimating the active and lifetime prevalence and incidence of epilepsy in Asian Countries: A systematic review and meta-analysis Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-21 Mohammed Safeer V S, Jitendra Kumar Sahu, Priyanka Madaan, Sebastian F. Winter, Gus A. Baker, Dipika Bansal
In the current era of the World Health Organization's Intersectoral Global Action Plan on Epilepsy and Other Neurological Disorders 2022–2031 (IGAP), precise and updated estimates of epilepsy burden are vital in formulating policies to improve the care of persons with epilepsy, especially in Asian countries with significant treatment gap. Hence, we aimed to consolidate the available data and quantify
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Utilization of APE2 and RITE2 scores in autoimmune encephalitis patients with seizures Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-21 Trevor Rafferty, Anna Koeppen-Babcock, Srikanth Muppidi, Yi Li, Scheherazade Le
Immune-mediated seizures are rare but are increasingly recognized as an etiology of seizures resistant to anti-seizure medications (ASMs). Antibody Prevalence in Epilepsy 2 (APE2) and Response to Immunotherapy in Epilepsy 2 (RITE2) scores were developed recently to identify patients who may be seropositive for serum central nervous system (CNS) specific antibodies (Ab) and may benefit from immunotherapy
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What we have learned from non-human primates as animal models of epilepsy Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-21 Viviam Sanabria, Simone A.A. Romariz, Matheus Braga, Jaime Moreira Pires, Maria da Graça Naffah-Mazzacoratti, Luiz Eugênio Mello, Beatriz M. Longo, Maira Licia Foresti
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Resilience and psychosocial factors in adult with epilepsy: A longitudinal study Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-20 M. Tombini, F. Narducci, L. Ricci, B. Sancetta, M. Boscarino, L. Quintiliani, J. Lanzone, M. Straffi, V. Di Lazzaro, G. Assenza
Resilience is conceptually characterized as a dynamic process encompassing positive adaptation in the context of significant adversity. Our goal was to assess the resilience in people with epilepsy (PWE) and how it impacts longitudinally on psychosocial factors, with a particular focus on the manifestation of stigmatization-related feelings. We consecutively enrolled 78 adults PWE (42.5 ± 16.2 years
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eDeeplepsy: An artificial neural framework to reveal different brain states in children with epileptic spasms Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-20 Alberto Nogales, Álvaro J. García-Tejedor, Juan Serrano Vara, Arturo Ugalde-Canitrot
Despite advances, analysis and interpretation of EEG still essentially rely on visual inspection by a super-specialized physician. Considering the vast amount of data that composes the EEG, much of the detail inevitably escapes ordinary human scrutiny. Significant information may not be evident and is missed, and misinterpretation remains a serious problem. Can we develop an artificial intelligence
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Mediating effects of sleep quality between clinical characteristics and quality of life in children with epilepsy: A cross-sectional study from Southwest China Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-20 Lisi Yan, Jin Chen, Lingling Xie, Tianyi Li, Yue Hu, Siqi Hong, Li Jiang
Although sleep quality (SQ) reportedly affects the health-related quality of life (QOL) of patients with epilepsy, little is known about the potential association between SQ and QOL, particularly in children with epilepsy (CWE). Our study aimed to investigate the mediating effect of SQ on the QOL of CWE to obtain more information for the prevention and treatment of epilepsy in children. We collected
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EEG microstates in epilepsy with and without cognitive dysfunction: Alteration in intrinsic brain activity Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-20 Shenzhi Fang, Chaofeng Zhu, Jinying Zhang, Luyan Wu, Yuying Zhang, Huapin Huang, Wanhui Lin
This study aims to investigate the difference between epilepsy comorbid with and without cognitive dysfunction. Participants were classified into patients with epilepsy comorbid cognitive dysfunction (PCCD) and patients with epilepsy without comorbid cognitive dysfunction (nPCCD). Microstate analysis was applied based on 20-channel electroencephalography (EEG) to detect the dynamic changes in the whole
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Understanding neurodevelopmental trajectories and behavioral profiles in SCN1A-related epilepsy syndromes Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-20 Amber Postma, Crista A. Minderhoud, Wim M. Otte, Floor E. Jansen, W.B. Gunning, Judith S. Verhoeven, Marian J. Jongmans, Janneke R. Zinkstok, Eva H. Brilstra
A pathogenic variant in can result in a spectrum of phenotypes, including Dravet syndrome (DS) and genetic epilepsy with febrile seizures plus (GEFS + ) syndrome. Dravet syndrome (DS) is associated with refractory seizures, developmental delay, intellectual disability (ID), motor impairment, and challenging behavior(1,2). GEFS + is a less severe phenotype in which cognition is often normal and seizures
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Detection of somatic and germline pathogenic variants in adult cohort of drug-resistant focal epilepsies Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-19 L. Ferri, V. Menghi, L. Licchetta, P. Dimartino, R. Minardi, C. Davì, L. Di Vito, E. Cifaldi, C. Zenesini, F. Gozzo, V. Pelliccia, V. Mariani, Y.C.C. de Spelorzi, S. Gustincich, M. Seri, L. Tassi, T. Pippucci, F. Bisulli
This study investigates the prevalence of pathogenic variants in the mechanistic target of rapamycin (mTOR) pathway in surgical specimens of malformations of cortical development (MCDs) and cases with negative histology. The study also aims to evaluate the predictive value of genotype-histotype findings on the surgical outcome. The study included patients with drug-resistant focal epilepsy who underwent
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Bidirectional relationship between late-onset epilepsy (LOE) and dementia: A systematic review and meta-analysis of cohort studies Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-14 Zheng Tan, Fu-Yu Wang, Wen-Pei Wu, Liu-Zhen-Xiong Yu, Jun-Cang Wu, Long Wang
To explore the bidirectional relationship of late-onset epilepsy (LOE) with dementia and Alzheimer’s disease (AD). Using the common electronic databases, including PubMed, Cochrane Library databases and EMBASE, we systematically reviewed published cohort studies that assessed the risk of LOE in individuals comorbid with dementia or AD, and those with dementia or AD comorbid with LOE that had been published
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Public misconceptions and attitudes towards persons diagnosed with epilepsy in the Kingdom of Bahrain: A cross-sectional study Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-07 Alaa Elmazny, Mohammed Ahmed A. Alkharisi, Yazed Saad J. Ibrahim, Atheer Baalqasim A. Albarakati, Shatha Shayan Almutairi, Lina Abdulrahim Altalhi, Enas Mostafa Darwish, Rehab Magdy, Eman Hany Elsebaie, Ahmed Dahshan
Despite significant advancements in the understanding and treatment of epilepsy, the quality of life for persons diagnosed with Epilepsy (PdwE) can still be negatively impacted due to prevalent misconceptions and societal attitudes. This study aimed to investigate the knowledge, misconceptions, and attitudes towards epilepsy in Bahrain. This cross-sectional study involved 1079 participants aged ≥ 18 years
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Longitudinal point-of-care assessment of psychomotor vigilance in children in the epilepsy monitoring unit Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-07 Karim Mithani, Simeon M. Wong, Hrishikesh Suresh, Ivanna Yau, Elizabeth N. Kerr, Mary Lou Smith, Elizabeth Donner, George M. Ibrahim
The epilepsy monitoring unit (EMU) is a complex and dynamic operational environment, where the cognitive and behavioural consequences of medical and environmental changes often go unnoticed. The psychomotor vigilance task (PVT) has been used to detect changes in cognition and behaviour in numerous contexts, including among astronauts on spaceflight missions, pilots, and commercial drivers. Here, we
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Neuropsychological Rehabilitation for Epilepsy in India: Looking Beyond the Basics Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-06 Shivani Sharma, Ashima Nehra, Shivam Pandey, Madhavi Tripathi, Achal Srivastava, M.V. Padma, Ajay Garg, R.M. Pandey, Sarat Chandra, Manjari Tripathi
Neuropsychological Rehabilitation (NR) helps manage cognitive deficits in epilepsy. As internationally developed programs have limited applicability to resource-limited countries, we developed a program to bridge this gap. This 6-week caregiver-assisted, culturally suitable program has components of (1) psychoeducation, (2) compensatory training, and, (3) cognitive retraining and is called EMPOWER
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Characteristics and outcomes of youth with functional seizures attending intensive interdisciplinary pain treatment Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-06 Jennifer A. Scheurich, Kelsey M. Klaas, Leslie A. Sim, Karen E. Weiss, Hannah F. Case, Cynthia Harbeck-Weber
Functional seizures (FS) can be debilitating and negatively impact quality of life. Yet intervention research for FS is limited, especially for youth. This study examined clinical characteristics and outcomes of youth with FS (13–23 years) presenting to a pediatric intensive interdisciplinary pain treatment (IIPT) program in the midwestern United States. Sixty youth (mean age = 16.5 years; 83.3 % female)
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Effect of duration of sodium valproate therapy on bone mineral density and vitamin D levels Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-05 Dinesh Nirmal, Samee Abdul, Poornima Jaiswal, S. Naunihal Singh, Amit Avaragollapuravarga Mathada, Preeti Nagaraj
This study aimed to evaluate the impact of prolonged sodium valproate use on bone mineral density (BMD) and Vitamin D levels in pediatric epilepsy patients. In a cross-sectional study conducted at the Epilepsy Clinic of Niloufer Hospital, Hyderabad, India, 50 pediatric patients (aged 4–10 years) were recruited. The cohort comprised 30 epilepsy patients on sodium valproate treatment (cases) and 20 healthy
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Pregnancy, antiseizure medications and unexplained intrauterine foetal death Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-04 Frank J.E. Vajda, Terence J. O'Brien, Janet E. Graham, Alison E. Hitchcock, Piero Perucca, Cecilie M. Lander, Mervyn J. Eadie
To assess the role of antiseizure medication (ASM) regimens and other factors in relation to the occurrence of intrauterine foetal death (IUFD) in pregnant women with epilepsy (WWE) enrolled in the Raoul Wallenberg Australian Pregnancy Register of Antiepileptic Drugs (APR). IUFDs occurred in 70 (3.01 %) of 2,323 prospective pregnancies from WWE with known outcomes in the APR. Factors associated with
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The role of stand-alone videos in the diagnosis of seizures Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-01 Ushtar Amin, Selim R. Benbadis
The diagnosis of seizures and seizure mimics relies primarily on the history, but history has well-known limitations. Video recordings of events are a powerful extension of the history because they allow neurologists to view the events in question. In addition, they are readily available in situation, whereas the gold standard of EEG-video is not. That includes underserved or rural areas, and events
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Patient experiences of resection versus responsive neurostimulation for drug-resistant epilepsy Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-01 Tobias Haeusermann, Emily Yang Liu, Kristina Celeste Fong, Daniel Dohan, Winston Chiong
This study explored illness experiences and decision-making among patients with epilepsy who underwent two different types of surgical interventions: resection versus implantation of the NeuroPace Responsive Neurostimulation System (RNS). We recruited 31 participants from a level four epilepsy center in an academic medical institution. We observed 22 patient clinic visits (resection: n = 10, RNS: n = 12)
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Tuberous sclerosis complex in adulthood: focus on epilepsy prognosis Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-29 Laura Licchetta, Giulia Bruschi, Carlotta Stipa, Laura Maria Beatrice Belotti, Lorenzo Ferri, Barbara Mostacci, Luca Vignatelli, Raffaella Minardi, Lidia Di Vito, Lorenzo Muccioli, Antonella Boni, Paolo Tinuper, Francesca Bisulli
Typically diagnosed in early childhood or adolescence, TSC is a chronic, multisystemic disorder with age-dependent manifestations posing a challenge for transition and for specific surveillance throughout the lifetime. Data on the clinical features and severity of TSC in adults and on the prognosis of epilepsy are scarce. We analyzed the clinical and genetic features of a cohort of adult patients with
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Translation and validation of the Vietnamese Epilepsy Self-Management Scale (V-ESMS) Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-29 Minh-An Thuy Le, Truong Thuong Nguyen, Tuan Le Van
This study aimed to translate and validate the Vietnamese version of the Epilepsy Self-Management Scale (V-ESMS). The translation and cross-cultural adaptation of the original version of the ESMS into Vietnamese followed the Principles of Good Practice for the Translation and Cultural Adaptation Process for Patient-Reported Outcomes Measures guideline with “forward–backward” translation and culturally
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Antiseizure medication withdrawal in adult patients with idiopathic generalized epilepsy: Performance of two seizure recurrence prediction models Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-29 Sofía Lallana, Elena Fonseca, Manuel Quintana, Laura Abraira, Daniel Campos-Fernández, Samuel López-Maza, Estevo Santamarina, Manuel Toledo, Javier Salas-Puig
Currently, there is a limited availability of tools to predict seizure recurrence after discontinuation of antiseizure medications (ASMs). This study aimed to establish the seizure recurrence rate following ASM cessation in adult patients with idiopathic generalized epilepsy (IGE) and to assess the predictive performance of the Lamberink and the Stevelink prediction models using real-world data. Retrospective
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Long-term memory consolidation of new words in children with self-limited epilepsy with centro-temporal spikes Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-29 C. Mayor, C. Moser, C. Korff
Accelerated long-term forgetting has been studied and demonstrated in adults with epilepsy. In contrast, the question of long-term consolidation (delays > 1 day) in children with epilepsy shows conflicting results. However, childhood is a period of life in which the encoding and long-term storage of new words is essential for the development of knowledge and learning. The aim of this study was therefore
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Epilepsy and education: A case-control analysis of the impact of an intensive epilepsy training program on undergraduate medical students Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-29 Roberto Diaz-Peregrino, Daniel San-Juan, Aleida Arritola-Uriarte, Álvaro Contreras-Salazar, Jesús del Moral-Bastida, Raúl Miranda-Ojeda
To evaluate the knowledge, attitudes, and practical skills of students submitted to a 6-week intensive training in epilepsy compared to students without any training but mandatory neurology classes. It is a case-control study. After completing a 6-week intensive Academic, Clinical, and Research Program in epilepsy, TUMSs answered a validated Knowledge Attitudes and Practices (KAP) questionnaire. The
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Comprehensive review of status gelasticus: Diagnostic challenges and therapeutic insights Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-29 Antonio Gennaro Nicotera, Giulia Spoto, Greta Amore, Ambra Butera, Gabriella Di Rosa
Status gelasticus is a rare form of status epilepticus characterized by prolonged and/or clustered gelastic seizures. The review encompasses an analysis of cases reported in the literature, focusing on causes, clinical-electroencephalographic features, and therapeutic interventions. The study reveals the challenges in defining and understanding status gelasticus due to its diverse etiologies and limited
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Socioeconomic status in adulthood of children with and without a history of seizures: A retrospective cohort study Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-29 Paolo P. Mazzone, Christopher J. Weir, Jacqueline Stephen, Sohinee Bhattacharya, Richard F.M. Chin
Compare adulthood socioeconomic status for children with and without a history of seizures. Retrospective cohort study using Aberdeen Children of the Nineteen Fifties (ACONF) data comprising children born 1950–1956 attending primary school 1962–1964, with follow-up data collected in 2001. Adulthood socioeconomic status was based on registrar general measure of occupational social class and categorised
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Experiences of using the MINDSET Self-Management mobile health app among Hispanic Patients:Results of a qualitative study Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-26 Refugio Sepulveda, Jenny Chong, Ross Shegog, Kimberly Martin, Charles Begley, Robert Addy, Omar Rosales, Tomas Nuño, Shiela Soto, Cecilia Rosales, David Labiner
Interventions focusing on epilepsy self-management (ESM) are vital for promoting the health of people living with epilepsy. E-technology and mobile health (mHealth) tools are becoming increasingly integrated into practice to promote self-management strategies for chronic diseases, enhance care delivery, and reduce health disparities. Management Information and Decision Support Epilepsy Tool (MINDSET)
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First epileptic seizure and quality of life – A prospective study Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-24 Louise Linka, Selina Nephuth, Iris Gorny, Kristina Krause, Peter Michael Mross, Panagiota-Eleni Tsalouchidou, Felix Zahnert, Sven Fuest, Katja Menzler, Susanne Knake, Lena Habermehl
Impaired QoL and depression are common in patients with chronic epilepsies; however, data on the impact of a first seizure on QoL are sparse. According to the current ILAE-definition of epilepsy, patients may be diagnosed with epilepsy immediately after the first seizure, if EEG and/or imaging findings are abnormal. Patients with normal findings in imaging and EEG are not diagnosed as having epilepsy
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Clinical Validation of Selected NIH Cognitive Toolbox Tasks in Pediatric Epilepsy Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-23 Emily Matuska, Allison Carney, Leigh N. Sepeta, Tesfaye Zelleke, Archana Pasupuleti, Madison M. Berl
The NIH Toolbox Cognition Battery (NIHTB-CB) is designed to assess cognitive functioning across the lifespan. We aimed to evaluate the clinical validity of two NIHTB-CB tasks as cognitive screening tools in pediatric epilepsy by comparing them to standard neuropsychological measures and their association with epilepsy characteristics. Forty-seven patients with epilepsy ages 5–18, including ten repeat
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Diagnostic utility of prolonged ambulatory video-electroencephalography monitoring Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-23 Michael C. Li, Udaya K. Seneviratne, Ewan S. Nurse, Mark J. Cook, Amy J. Halliday
Ambulatory video-electroencephalography (video-EEG) represents a low-cost, convenient and accessible alternative to inpatient video-EEG monitoring, however few studies have examined their diagnostic yield. In this large-scale retrospective study conducted in Australia, we evaluated the efficacy of prolonged ambulatory video-EEG recordings in capturing diagnostic events and resolving the referring question
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Testing the diagnostic accuracy of common questions for seizure diagnosis: Challenges and future directions Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-23 Ellen Snyder, Stefan Sillau, Kelly G. Knupp, Jacqueline French, Amber Khanna, Marius Birlea, Kavita Nair, Jacob Pellinen
The aim of this study was to evaluate the diagnostic accuracy of common interview questions used to distinguish a diagnosis of epilepsy from seizure mimics including non-epileptic seizures (NES), migraine, and syncope. 200 outpatients were recruited with an established diagnosis of focal epilepsy (n = 50), NES (n = 50), migraine (n = 50), and syncope (n = 50). Patients completed an eight-item, yes-or-no
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Negative MRI and a seizure onset zone close to eloquent areas in FCD type II: Application of MRg-LiTT after a SEEG re-evaluation in pediatric patients with a previous failed surgery Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-23 D. Chiarello, E. Cognolato, S. Francione, G. Nobile, L. Bosisio, G. Barbagallo, M. Pacetti, D. Tortora, G. Cantalupo, L. Nobili, A. Consales
Negative MRI and an epileptogenic zone (EZ) adjacent to eloquent areas are two main issues that can be encountered during pre-surgical evaluation for epilepsy surgery. Focal Cortical Dysplasia type II (FCD type II) is the most common aetiology underlying a negative MRI. Pediatric patients who underwent SEEG followed by MRg-LiTT for drug-resistant epilepsy associated with FCD type II at our Centre were
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Polygenic burden and its association with baseline cognitive function and postoperative cognitive outcome in temporal lobe epilepsy Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-22 Kayela Arrotta, Lisa Ferguson, Nicolas Thompson, Victoria Smuk, Imad M. Najm, Costin Leu, Dennis Lal, Robyn M. Busch
Demographic and disease factors are associated with cognitive deficits and postoperative cognitive declines in adults with pharmacoresistant temporal lobe epilepsy (TLE), but the role of genetic factors in cognition in TLE is not well understood. Polygenic scores (PGS) for neurological and neuropsychiatric disorders and IQ have been associated with cognition in patient and healthy populations. In this
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Epilepsy and driving: A preliminary survey of people with epilepsy at an epilepsy clinic in China Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-22 Xiantao Li, Yuan Pei, Yan Ge, Lan Xu, Yue Zhang, Li Zheng, Ding Ding, Zhen Hong, PeiminYu
Driving is an important part of the daily life for most adults, and restrictions on driving can significantly affect the quality of life for people with epilepsy. This study aimed to investigate the current driving status of patients at an epilepsy clinic in China. Study participants were administered a survey by a questionnaire including the demographic and clinical characteristics of seizure, driving-related
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Seizure control and complications in patients switching from clobazam to clonazepam due to drug shortage Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-21 Oğuzhan Fırat, Melike Çakan, Kutay Demirkan, Neşe Dericioğlu
Antiseizure medication (ASM) shortages are a global problem that have a negative impact on outcomes such as seizure control in patients with epilepsy (PWE). In the case of clobazam (CLB) shortage, there is no study regarding the management strategy. This study aims to investigate the alteration in seizure frequency and the occurrence of side effects in PWE undergoing an abrupt switch from clobazam
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Illness representations of people with later-onset functional seizures Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-20 I.A. Williams, P.G. Morris, K. Forristal, J. Stone, D.C. Gillespie
Although functional seizures can start at any age, little is known about the individuals for whom onset occurs after the age of 40. It has been proposed that health-related traumatic events are more relevant causal factors for people with ‘later-onset functional seizures’ than for those whose functional seizures begin earlier in life, however, the illness representations of people with later-onset
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Mental health and neurodevelopmental patient-reported outcome measures (PROMs) for children and young people with epilepsy: A systematic review Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-19 Bianca De Aveiro, Alice Winsor, Jessica Davies, Timothy R. Nicholson, Deb K. Pal, Mark P. Richardson, Susannah Pick
Children and young people with epilepsy are at higher risk of mental health disorders and atypical neurodevelopmental outcomes compared to the general population. It is essential to detect such comorbidities early in children with epilepsy and provide appropriate interventions, to improve clinical outcomes. We aimed to identify and evaluate the measurement properties of Patient-Reported Outcome Measures
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Risk factors for anxiety in patients with epilepsy: A meta-analysis Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-19 Cailang Niu, Penghong Li, Xueqing Du, Mina Zhao, Haobo Wang, Debo Yang, Maolin Wu, Wei Jing
Epilepsy is a very common neurological disease, and it is important to focus on both controlling seizures and alleviating the psychological problems associated with this disease.Anxiety is an important risk factor for epilepsy and seriously affects the quality of life of patients with epilepsy (PWE). However, several risk factors for anxiety in PWE are relatively controversial and understudied. This
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Prevalence and factors associated with psychosis among adults with epilepsy at a tertiary hospital in Uganda, cross-sectional study Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-19 Julius Ceasar Kimera, Etheldreda Mpungu Nakimuli, Andrew Kampikaho Turiho, Jennifer Levin, Martin Kaddumukasa, Martha Sajatovic, Elly Katabira, Mark Kaddumukasa
Psychotic disorders are prevalent among people with epilepsy compared to the general population. However, there is limited information regarding psychosis among people with epilepsy in Uganda. This study therefore determined the prevalence and associated factors of psychosis among adults with epilepsy attending Butabika National Referral Mental Hospital in Uganda. This was a cross-sectional study involving
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Response Letter to the Editor: “Expanding eligibility for intracranial electroencephalography using dexmedetomidine hydrochloride in children with behavioral dyscontrol” Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-17 Thomas Johnstone, Maria Isabel Barros Guinle, Gerald A. Grant, Brenda E. Porter
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Attention-deficit hyperactivity disorder in adults with epilepsy: An indirect relationship with suicide risk Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-17 Eun Ju Choi, Mina Jung, Tae-Young Kim, Boyoung Kim, Sang-Ahm Lee
Studies on attention-deficit hyperactivity disorder (ADHD) are scarce in adults with epilepsy. This study aimed to investigate the risk factors for ADHD and determine whether ADHD is directly associated with the risk of suicide in adults with epilepsy. ADHD was assessed using the Structured Clinical Interview for the DSM-5 Disorders Clinical Version. The Mini International Neuropsychiatric Interview
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Caregiver burden and its predictors in adult epilepsy patients Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-17 Kubra Yeni, Zeliha Tulek, Aysel Cavusoglu, Cansu Polat Dunya, Sevda Ozturk Erden, Nur Sena Bostan, Nerses Bebek, Betul Baykan
The aim of this study was to evaluate caregiver burden and factors associated with caregiver burden in caregivers of adults with epilepsy. This descriptive cross-sectional study was conducted with 107 patients with epilepsy and 107 their primary caregivers. Personal information form including sociodemographic data and Zarit Caregiver Burden Inventory (ZBI), were used for caregivers, and patient information
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Neuropsychological outcome after frontal surgery for pediatric-onset epilepsy with focal cortical dysplasia in adolescent and young adult Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-17 Nobusuke Kimura, Yukitoshi Takahashi, Naotaka Usui, Kazumi Matsuda, Hideyuki Otani, Yoshinobu Kasai, Akihiko Kondo, Katsumi Imai, Junko Takita
We investigated neuropsychological outcome in patients with pharmacoresistant pediatric-onset epilepsy caused by focal cortical dysplasia (FCD), who underwent frontal lobe resection during adolescence and young adulthood. Twenty-seven patients were studied, comprising 15 patients who underwent language-dominant side resection (LDR) and 12 patients who had languagenondominant side resection (n-LDR)
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Post-traumatic seizures and factors associated among adult patients with depressed skull fractures at Mulago National Referral hospital; cross-sectional study Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-17 Ronald Oboth, Larrey Kasereka Kamabu, Herve M. Lekuya, Godfrey S. Bbosa, Martha Sajatovic, Elly Katabira, Mark Kaddumukasa, Moses Galukande
Post-traumatic seizures (PTS) are common among patients with depressed skull fractures (DSF). Understanding the burden of post traumatic seizures and the factors associated among adult patients with DSF is important to improve clinical care. To determine the prevalence and factors associated with post-traumatic seizures among adult patients with DSF at Mulago National Referral hospital (MNRH). A cross-sectional
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Neutrophil to lymphocyte ratio and early seizures after ischemic stroke: A case-control study Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-15 Lea Ebner, Piergiorgio Lochner, Simona Lattanzi, Francesco Brigo, Gudrun Wagenpfeil, Klaus Faßbender, Frauke Röll
Early post-stroke seizures (EPSS) are associated with an increased risk of mortality and post-stroke epilepsy. This study aimed to identify potential risk factors for EPSS, focusing on blood parameters, such as the neutrophil-to-lymphocyte ratio (NLR), which is a biomarker for inflammation. Patients treated for ischemic stroke between 2017 and 2019 were retrospectively identified. 44 of them had a
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Cognitive development in children with new-onset Rolandic epilepsy and Rolandic discharges without seizures: Focusing on intelligence, visual perception, working memory and the role of parents’ education Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-12 Helmut Neumann, Monika Daseking, Charlotte Thiels, Cornelia Köhler, Thomas Lücke
Our aim was to assess intelligence, visual perception and working memory in children with new-onset Rolandic epilepsy (RE) and children with Rolandic discharges without seizures (RD). The participants in the study were 12 children with RE and 26 children with RD aged 4 to 10 years (all without medication and shortly after diagnosis) and 31 healthy controls. Their cognitive performance was assessed
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The burden of epilepsy on long-term outcome of genetic developmental and epileptic encephalopathies: A single tertiary center longitudinal retrospective cohort study Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-08 Mario Mastrangelo, Filippo Manti, Giacomina Ricciardi, Rossella Bove, Carlo Greco, Manuela Tolve, Francesco Pisani
This retrospective cohort analysis highlighted neurodevelopmental outcome predictors of genetic developmental and epileptic encephalopathies (DEE). Patients’ demographic, clinical and molecular genetics data were collected. All patients underwent clinical, developmental, and neuropsychological assessments. We recruited 100 participants (53 males, 47 females) with a mean follow-up lasting 10.46 ± 8
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The lived experience of young adults with Fetal Valproate Spectrum Disorder, and the perspective of their parents: A qualitative study Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-08 S Khanom, D Astill, N Astill, J Cozens, B Mann, J Garratt, R L Bromley
While research has investigated the physical and neurodevelopmental consequences following prenatal exposure to valproate, our understanding of individuals with a formal diagnosis of Fetal Valproate Spectrum Disorder (FVSD), particularly in the context of adulthood, remains limited. To investigate how symptoms and challenges of FVSD present in adulthood. 30 people took part in the study, including
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CBD treatment following early life seizures alters orbitofrontal-striatal signaling during adulthood Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-06 Natalie A. Cashen, Michelle L. Kloc, Davi Pressman, Samuel A. Liebman, Gregory L. Holmes