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Determining a musculoskeletal system’s pre-stretched state using continuum–mechanical forward modelling and joint range optimization Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-04-15 Okan Avci, Oliver Röhrle
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The mechanical effects of chemical stimuli on neurospheres Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-04-13 Yun-Han Huang, Roza Vaez Ghaemi, James Cheon, Vikramaditya G. Yadav, John M. Frostad
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A continuum model for the elongation and orientation of Von Willebrand factor with applications in arterial flow Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-04-09 E. F. Yeo, J. M. Oliver, N. Korin, S. L. Waters
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Biventricular finite element modeling of the fetal heart in health and during critical aortic stenosis Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-04-08 Meifeng Ren, Wei Xuan Chan, Laura Green, Martin L. Buist, Choon Hwai Yap
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Treatment for middle cerebral artery bifurcation aneurysms: in silico comparison of the novel Contour device and conventional flow-diverters Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-04-08 Mengzhe Lyu, Ryo Torii, Ce Liang, Thomas W. Peach, Pervinder Bhogal, Levansri Makalanda, Qiaoqiao Li, Yiannis Ventikos, Duanduan Chen
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Potential of computational models in personalized treatment of obstructive sleep apnea: a patient-specific partial 3D finite element study Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-04-01 Venkat Ayyalasomayajula, Mads Moxness, Bjørn Skallerud
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Unraveling the complexity of vascular tone regulation: a multiscale computational approach to integrating chemo-mechano-biological pathways with cardiovascular biomechanics Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-03-20 Michele Marino, Bastien Sauty, Giuseppe Vairo
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Muscle and joint mechanics during maximum force biting following total temporomandibular joint replacement surgery Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-03-19 Sarah C. Woodford, Dale L. Robinson, Jaafar Abduo, Peter V. S. Lee, David C. Ackland
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A homeostatic role of nucleus-actin filament coupling in the regulation of cellular traction forces in fibroblasts Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-03-19 Naoya Sakamoto, Keisuke Ito, Satoshi Ii, Daniel E. Conway, Yuki Ueda, Jiro Nagatomi
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Application of Data-Driven computing to patient-specific prediction of the viscoelastic response of human brain under transcranial ultrasound stimulation Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-03-19 Hossein Salahshoor, Michael Ortiz
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Three-dimensional wall-thickness distributions of unruptured intracranial aneurysms characterized by micro-computed tomography Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-03-15 Yasutaka Tobe, Takanobu Yagi, Koichi Kawamura, Kenta Suto, Yoichi Sawada, Yoshifumi Hayashi, Hirotaka Yoshida, Kazutoshi Nishitani, Yoshifumi Okada, Shigemi Kitahara, Mitsuo Umezu
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A quadriphasic mechanical model of the human dermis Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-03-15 David Sachs, Raphael Jakob, Gaetana Restivo, Jürg Hafner, Nicole Lindenblatt, Alexander E. Ehret, Edoardo Mazza
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Frequency and time dependent viscoelastic characterization of pediatric porcine brain tissue in compression Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-03-14 Weiqi Li, Duncan E. T. Shepherd, Daniel M. Espino
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Muscle synergy-informed neuromusculoskeletal modelling to estimate knee contact forces in children with cerebral palsy Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-03-09 Mohammad Fazle Rabbi, Giorgio Davico, David G. Lloyd, Christopher P. Carty, Laura E. Diamond, Claudio Pizzolato
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An explainable machine learning-based probabilistic framework for the design of scaffolds in bone tissue engineering Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-02-28
Abstract Recently, 3D-printed biodegradable scaffolds have shown great potential for bone repair in critical-size fractures. The differentiation of the cells on a scaffold is impacted among other factors by the surface deformation of the scaffold due to mechanical loading and the wall shear stresses imposed by the interstitial fluid flow. These factors are in turn significantly affected by the material
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Finite element model of ocular adduction with unconstrained globe translation Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-02-28 Somaye Jafari, Joseph Park, Yongtao Lu, Joseph L. Demer
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Mechanical complexity of living cells can be mapped onto simple homogeneous equivalents Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-02-27 Sebastian Wohlrab, Sebastian Mueller, Stephan Gekle
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Quantifying fat zonation in liver lobules: an integrated multiscale in silico model combining disturbed microperfusion and fat metabolism via a continuum biomechanical bi-scale, tri-phasic approach Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-02-25 Lena Lambers, Navina Waschinsky, Jana Schleicher, Matthias König, Hans-Michael Tautenhahn, Mohamed Albadry, Uta Dahmen, Tim Ricken
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Age and sex-dependent sensitivity analysis of a common carotid artery model Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-02-19 Friederike Schäfer, Jacob Sturdy, Leif Rune Hellevik
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Effect of twisting of intravitreal injections on ocular bio-mechanics: a novel insight to ocular surgery Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-02-15 Ashish Siddharth, Ajay Bhandari, Sarthak S. Singh, Arun Dayal Udai
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Mechanical characterization and torsional buckling of pediatric cardiovascular materials Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-02-15
Abstract In complex cardiovascular surgical reconstructions, conduit materials that avoid possible large-scale structural deformations should be considered. A fundamental mode of mechanical complication is torsional buckling which occurs at the anastomosis site due to the mechanical instability, leading surgical conduit/patch surface deformation. The objective of this study is to investigate the torsional
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Influence of material parameter variability on the predicted coronary artery biomechanical environment via uncertainty quantification Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-02-15 Caleb C. Berggren, David Jiang, Y. F. Jack Wang, Jake A. Bergquist, Lindsay C. Rupp, Zexin Liu, Rob S. MacLeod, Akil Narayan, Lucas H. Timmins
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A comparison of brain retraction mechanisms using finite element analysis and the effects of regionally heterogeneous material properties Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-02-15 Emma Griffiths, Jayaratnam Jayamohan, Silvia Budday
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Discrete network models of endothelial cells and their interactions with the substrate Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-02-14
Abstract Endothelial cell monolayers line the inner surfaces of blood and lymphatic vessels. They are continuously exposed to different mechanical loads, which may trigger mechanobiological signals and hence play a role in both physiological and pathological processes. Computer-based mechanical models of cells contribute to a better understanding of the relation between cell-scale loads and cues and
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Effect of meniscus modelling assumptions in a static tibiofemoral finite element model: importance of geometry over material Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-02-13
Abstract Finite element studies of the tibiofemoral joint have increased use in research, with attention often placed on the material models. Few studies assess the effect of meniscus modelling assumptions in image-based models on contact mechanics outcomes. This work aimed to assess the effect of modelling assumptions of the meniscus on knee contact mechanics and meniscus kinematics. A sensitivity
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A fast in silico model for preoperative risk assessment of paravalvular leakage Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-02-11 Michelle Spanjaards, Finja Borowski, Laura Supp, René Ubachs, Valentina Lavezzo, Olaf van der Sluis
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Uniaxial mechanical stretch properties correlated with three-dimensional microstructure of human dermal skin Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-02-07 Mengyao Zhou, Patrick José González, Ludo Van Haasterecht, Alperen Soylu, Maria Mihailovski, Paul Van Zuijlen, Marie Louise Groot
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A molecular arm: the molecular bending–unbending mechanism of integrin Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-02-03 Zhenhai Li
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Effect of collagen fibril orientation on the anisotropic properties of peri-implant bone Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-02-01
Abstract In orthopedic and dental surgery, the implantation of biomaterials within the bone to restore the integrity of the treated organ has become a standard procedure. Their long-term stability relies on the osseointegration phenomena, where bone grows onto and around metallic implants, creating a bone-implant interface. Bone is a highly hierarchical material that evolves spatially and temporally
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Bone turnover and mineralisation kinetics control trabecular BMDD and apparent bone density: insights from a discrete statistical bone remodelling model Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-01-27 Natalia M. Castoldi, Edmund Pickering, Vittorio Sansalone, David Cooper, Peter Pivonka
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Research on ultrasonic bone cutting mechanism based on extended finite element method Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-01-23 Linwei Wang, Yu Liu, Shiwei Wang, Jinguang Li, Yumeng Sun, Jingyu Wang, Qilei Zou
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A new method to design energy-conserving surrogate models for the coupled, nonlinear responses of intervertebral discs Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-01-20
Abstract The aim of this study was to design physics-preserving and precise surrogate models of the nonlinear elastic behaviour of an intervertebral disc (IVD). Based on artificial force-displacement data sets from detailed finite element (FE) disc models, we used greedy kernel and polynomial approximations of second, third and fourth order to train surrogate models for the scalar force-torque -potential
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A physics-informed deep learning framework for modeling of coronary in-stent restenosis Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-01-18 Jianye Shi, Kiran Manjunatha, Marek Behr, Felix Vogt, Stefanie Reese
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Segmenting mechanically heterogeneous domains via unsupervised learning Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-01-13
Abstract From biological organs to soft robotics, highly deformable materials are essential components of natural and engineered systems. These highly deformable materials can have heterogeneous material properties, and can experience heterogeneous deformations with or without underlying material heterogeneity. Many recent works have established that computational modeling approaches are well suited
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Numerical study of ultra-large von Willebrand factor multimers in coagulopathy Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-01-13
Abstract An excessive von Willebrand factor (VWF) secretion, coupled with a moderate to severe deficiency of ADAMTS13 activity, serves as a linking mechanism between inflammation to thrombosis. The former facilitates platelet adhesion to the vessel wall and the latter is required to cleave VWF multimers. As a result, the ultra-large VWF (UL-VWF) multimers released by Weibel–Palade bodies remain uncleaved
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Multiscale mechanical characterisation of the craniofacial system under external forces Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-01-13 Marius Didziokas, Dominic Jones, Ali Alazmani, Miranda Steacy, Erwin Pauws, Mehran Moazen
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Investigation of direction- and age-dependent prestretch in mouse cranial dura mater Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2024-01-11 Jack Consolini, Alyssa G. Oberman, John Sayut, Frederick W. Damen, Craig J. Goergen, Matthew J. Ravosa, Maria A. Holland
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Nonlocal damage evaluation of a sigmoid-based damage model for fibrous biological soft tissues Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2023-12-29 Sofía Suárez, Jose A. López-Campos, Jose R. Fernández, Abraham Segade
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Multiscale insights into postnatal aortic development Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2023-12-27 Bruno V. Rego, Sae-Il Murtada, Guangxin Li, George Tellides, Jay D. Humphrey
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Mechano-chemo-biological model of atherosclerosis formation based on the outside-in theory Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2023-12-23 Meike Gierig, Alexandros Tragoudas, Axel Haverich, Peter Wriggers
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The inclusion of the epithelium in numerical models of the human cornea Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2023-12-21
Abstract We present a patient-specific finite element model of the human cornea that accounts for the presence of the epithelium. The thin anterior layer that protects the cornea from the external actions has a scant relevance from the mechanical point of view, and it has been neglected in most numerical models of the cornea, which assign to the entire cornea the mechanical properties of the stroma
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The role of interface geometry and appendages on the mesoscale mechanics of the skin Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2023-12-21
Abstract The skin is the largest organ in the human body and serves various functions, including mechanical protection and mechanosensation. Yet, even though skin’s biomechanics are attributed to two main layers—epidermis and dermis—computational models have often treated this tissue as a thin homogeneous material or, when considering multiple layers, have ignored the most prominent heterogeneities
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Multiscale computational modeling of aortic valve calcification Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2023-12-13 Javid Azimi-Boulali, Gretchen J. Mahler, Bruce T. Murray, Peter Huang
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Mechanical properties of human hepatic tissues to develop liver-mimicking phantoms for medical applications Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2023-12-10 Aicha S. Lemine, Zubair Ahmad, Noora J. Al-Thani, Anwarul Hasan, Jolly Bhadra
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On the necessity to include arterial pre-stress in patient-specific simulations of minimally invasive procedures Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2023-12-08 Anna Ramella, Vittorio Lissoni, Sara Bridio, Jose Felix Rodriguez Matas, Santi Trimarchi, Benedetta Grossi, Giulio G. Stefanini, Francesco Migliavacca, Giulia Luraghi
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Stenosis to stented: decrease in flow disturbances following stent implantation of a diseased arteriovenous fistula Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2023-12-08 Sanjiv Gunasekera, Charitha de Silva, Olivia Ng, Shannon Thomas, Ramon Varcoe, Tracie Barber
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Mechanical communication within the microtubule through network-based analysis of tubulin dynamics Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2023-12-07 Marco Cannariato, Eric A. Zizzi, Lorenzo Pallante, Marcello Miceli, Marco A. Deriu
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Modelling lipid rafts formation through chemo-mechanical interplay triggered by receptor–ligand binding Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2023-12-07 Chiara Bernard, Angelo Rosario Carotenuto, Nicola Maria Pugno, Massimiliano Fraldi, Luca Deseri
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Subject-specific one-dimensional fluid dynamics model of chronic thromboembolic pulmonary hypertension Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2023-11-29 Amirreza Kachabi, Mitchel J. Colebank, Naomi C. Chesler
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Physical biology of cell–substrate interactions under cyclic stretch Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2023-11-27 Siddhartha Jaddivada, Namrata Gundiah
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Mechanical experimentation of the gastrointestinal tract: a systematic review Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2023-11-08 Ciara Durcan, Mokarram Hossain, Grégory Chagnon, Djordje Perić, Edouard Girard
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Growth and remodeling of the dissected membrane in an idealized dissected aorta model Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2023-11-10 Lise Gheysen, Lauranne Maes, Nele Famaey, Patrick Segers
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A new model for evaluating pressure-induced vascular tone in small cerebral arteries Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2023-11-04 Alberto Coccarelli, Sanjay Pant, Ioannis Polydoros, Osama F. Harraz
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Computational fluid dynamic modeling of the lymphatic system: a review of existing models and future directions Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2023-10-30 Tharanga D. Jayathungage Don, Soroush Safaei, Gonzalo D. Maso Talou, Peter S. Russell, Anthony R. J. Phillips, Hayley M. Reynolds
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On the comparison between pre- and post-surgery nasal anatomies via computational fluid dynamics Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2023-10-30 Eric Segalerba, Gabriele Dini Ciacci, Maurizio Quadrio, Jan O. Pralits
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Dynamic strain fields of the mouse brain during rotation Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2023-10-28 Connor Bradfield, Liming Voo, David Drewry, Vassilis Koliatsos, K. T. Ramesh
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In silico analysis shows that dynamic changes in curvature guide cell migration over long distances Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2023-10-24 Ian Manifacier, Gildas Carlin, Dongshu Liu, Maxime Vassaux, Laurent Pieuchot, Valeriy Luchnikov, Karine Anselme, Jean-Louis Milan
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Mechanical behavior and microstructure of porcine brain tissues under pulsed electric fields Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2023-10-20 Yiqiang Li, Qixun Zhang, Jiucheng Zhao, Zhaoxin Wang, Xiangyu Zong, Li Yang, Chi Zhang, Hongwei Zhao
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Modeling the effects of external oscillations on mucus clearance in obstructed airways Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2023-10-20 Yusuf Hamida El Naser, Durmuş Karayel
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Cortical bone adaptation response is region specific, but not peak load dependent: insights from $$\mu$$ CT image analysis and mechanostat simulations of the mouse tibia loading model Biomech. Model. Mechanobiol. (IF 3.5) Pub Date : 2023-10-18 Corey J. Miller, Edmund Pickering, Saulo Martelli, Enrico Dall’Ara, Peter Delisser, Peter Pivonka