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Copy Number Variation Analysis of Aggressive Behaviour in Schizophrenia. Neuropsychobiology (IF 3.2) Pub Date : 2023-11-20 Vincenzo De Luca,Zanib Chaudhary,Nzaar Al-Chalabi,Jessica Qian,Xiaoguang Xu,Philip Gerretsen,Ali Bani-Fatemi,Alexander Simpson,Corinne Fischer,Ariel Graff,Nathan J Kolla
INTRODUCTION An increased proclivity towards violence is often associated with those diagnosed with schizophrenia (SCZ), despite contradictory findings from prior studies exploring the association between violence and SCZ. Evidence has shown that certain comorbidities, specifically the presence of a substance use disorders, can result in increased aggression in those with SCZ. Copy number variation
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Dopamine and Alcohol: A Review of in vivo PET and SPECT Studies. Neuropsychobiology (IF 3.2) Pub Date : 2023-11-14 Gianna Spitta,Maria Garbusow,Ralph Buchert,Andreas Heinz
BACKGROUND Alcohol-associated alterations of the dopaminergic (DA) system have been investigated via functional single-photon emission tomography (SPECT) positron emission tomography (PET) and imaging methods over many years, investigating presynaptic or postsynaptic markers, such as DA receptor and DA transporter availability, both with and without challenge. This review summarizes SPECT and PET studies
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Rostral Anterior Cingulate Cortex Oscillatory Power Indexes Treatment-Resistance to Multiple Therapies in Major Depressive Disorder. Neuropsychobiology (IF 3.2) Pub Date : 2023-10-17 Amourie Prentice,Ana Rita Barreiros,Nikita van der Vinne,Sven Stuiver,Hanneke van Dijk,Jeroen Antonius van Waarde,Mayuresh Korgaonkar,Alexander T Sack,Martijn Arns
INTRODUCTION High rostral anterior cingulate cortex (rACC) activity is proposed as a nonspecific prognostic marker for treatment response in major depressive disorder, independent of treatment modality. However, other studies report a negative association between baseline high rACC activation and treatment response. Interestingly, these contradictory findings were also found when focusing on oscillatory
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Altered Putamen Activation for Social Comparison-Related Feedback in Social Anxiety Disorder: A Pilot Study. Neuropsychobiology (IF 3.2) Pub Date : 2023-09-15 Huiyan Lin,Maximilian Bruchmann,Thomas Straube
INTRODUCTION Social anxiety disorder (SAD) is characterized by abnormal processing of performance-related social stimuli. Previous studies have shown altered emotional experiences and activations of different sub-regions of the striatum during processing of social stimuli in patients with SAD. However, whether and to what extent social comparisons affect behavioural and neural responses to feedback
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Psychological Stress and Gut Microbiota Composition: A Systematic Review of Human Studies. Neuropsychobiology (IF 3.2) Pub Date : 2023-09-06 Lu Ma,Yating Yan,Richard James Webb,Ying Li,Sanaz Mehrabani,Bao Xin,Xiaomin Sun,Youfa Wang,Mohsen Mazidi
INTRODUCTION The associations between psychological stress and gut microbiota composition are not fully understood. This study investigated associations between psychological stress and gut microbiota composition and examined the potential modifying effects of age, sex, and ethnicity on such associations. METHODS A systematic literature search was conducted using PubMed, Web of Science, PsycINFO, and
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The Involvement of PGRMC1 Signaling in Cognitive Impairment Induced by Long-Term Clozapine Treatment in Rats. Neuropsychobiology (IF 3.2) Pub Date : 2023-09-06 Ting Cao,LiWei Wang,ShiMeng Jiao,Hui Chen,ChenQuan Lin,BiKui Zhang,HuaLin Cai
INTRODUCTION Progesterone receptor component 1 (PGRMC1) has been identified as a potential target in atypical antipsychotic drug-induced metabolic disturbances as well as neuroprotection in the central nervous system. In our study, we aimed to figure out the essential role of PGRMC1 signaling pathway underlying clozapine-induced cognitive impairment. METHODS In male SD rats, we utilized recombinant
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Histidine Metabolic Pathway Contributes to Clozapine-Induced Sialorrhea Based on Nontargeted Metabolomics. Neuropsychobiology (IF 3.2) Pub Date : 2023-08-28 Kun Zhang,Shengwei Wu,Youtian Wang,Yufang Zhou,Jianxiong Guo,Aixiang Xiao,Junrong Ye,Baofeng Wu,Shuyun Li,Fujian Zhu,Zezhi Li,Lin Yu
INTRODUCTION Clozapine-induced sialorrhea (CIS) is one of the most common side effects of clozapine use, while the mechanism remains unclear. METHODS A total of 51 schizophrenia patients taking clozapine were selected. Among them, 32 had sialorrhea, and 19 had no sialorrhea. Saliva metabolites were identified using ultra-high-performance liquid chromatography-MS/MS (UHPLC-MS/MS), and the differences
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Response to Treatment in 3q29 Deletion Syndrome-Associated Psychosis: A Mini-Review. Neuropsychobiology (IF 3.2) Pub Date : 2023-08-22 Mark Ainsley Colijn
3q29 deletion syndrome is characterized by various developmental abnormalities, medical issues, and neuropsychiatric symptoms, including psychosis. Although this syndrome may confer the greatest risk for schizophrenia of any copy number variation, response to antipsychotic medication has infrequently been described in the literature, and no reviews on the topic currently exist. As such, the purpose
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Effectiveness and Changes in Brain Functions by an Occupational Therapy Program Incorporating Mindfulness in Outpatients with Anxiety and Depression: A Randomized Controlled Trial. Neuropsychobiology (IF 3.2) Pub Date : 2023-08-10 Atsuko Yamamoto,Banri Tsukuda,Shota Minami,Seina Hayamizu,Minami Naito,Yosuke Koshikawa,Toshiya Funatsuki,Chikashi Takano,Haruhiko Ogata,Yoshiteru Takekita,Keiichiro Nishida,Shunichiro Ikeda,Toshihiko Kinoshita,Masaki Kato
INTRODUCTION This study examined the efficacy of an 8-week occupational therapy program incorporating mindfulness (MOT) as a form of psychiatric rehabilitation to ameliorate residual social and occupational impairment in patients with anxiety disorders and depression. The objective was to evaluate the effects of MOT on their personal well-being and to assess the impact of MOT on brain function using
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Social Buffering Effects during Craft Activities in Parallel Group Session Revealed by EEG Analysis and Parasympathetic Activity. Neuropsychobiology (IF 3.2) Pub Date : 2023-08-10 Junya Orui,Keigo Shiraiwa,Fumie Tazaki,Takao Inoue,Masaya Ueda,Keita Ueno,Yasuo Naito,Ryouhei Ishii
INTRODUCTION The therapeutic structure of occupational therapy (OT) includes groups. Although the presence of others is expected to be relaxing due to the social buffering effect and the tend and befriend theory, it has not been sufficiently validated in accordance with the therapeutic structure of OT. The aim of this study was to investigate the electrophysiological evidence for the effectiveness
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Fingernail Cortisol: A Biological Signal of Lifetime Major Depressive Disorder. Neuropsychobiology (IF 3.2) Pub Date : 2023-08-09 Sarah Schumacher,Sebastian Laufer,Susanne Fischer
INTRODUCTION Elevated levels of the hypothalamic-pituitary-adrenal axis hormone cortisol are a frequently replicated finding in major depressive disorder (MDD). However, the current state of research is inconclusive as to whether hypercortisolism represents a trait- or state-like biological signal of MDD. The aim of the present study was to investigate, for the first time, whether cortisol in fingernails
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Deep Learning in the Identification of Electroencephalogram Sources Associated with Sexual Orientation. Neuropsychobiology (IF 3.2) Pub Date : 2023-06-27 Anastasios Ziogas,Andreas Mokros,Wolfram Kawohl,Mateo de Bardeci,Ilyas Olbrich,Benedikt Habermeyer,Elmar Habermeyer,Sebastian Olbrich
INTRODUCTION It is unclear if sexual orientation is a biological trait that has neurofunctional footprints. With deep learning, the power to classify biological datasets without an a priori selection of features has increased by magnitudes. The aim of this study was to correctly classify resting-state electroencephalogram (EEG) data from males with different sexual orientation using deep learning and
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Effects of Psychotherapy on Glutamatergic Neurotransmission. Neuropsychobiology (IF 3.2) Pub Date : 2023-06-15 Laura Wade-Bohleber,Niklaus Zoelch,Mick Lehmann,Jutta Ernst,André Richter,Erich Seifritz,Heinz Boeker,Simone Grimm
INTRODUCTION Psychodynamic psychotherapy is an effective and widely used treatment for major depressive disorder (MDD); however, little is known about neurobiological changes associated with induced symptom improvement. METHODS Proton magnetic resonance spectroscopy with a two-dimensional J-resolved sequence served to test the relationship between glutamate (Glu) and glutamine (Gln) levels, measured
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Gut Microbiome Composition and Its Association with Sleep in Major Psychiatric Disorders. Neuropsychobiology (IF 3.2) Pub Date : 2023-06-15 Marco Mairinger,Alexander Maget,Jolana Wagner-Skacel,Sabrina Mörkl,Nina Dalkner,Teresa Hellinger,Armin Birner,Frederike T Fellendorf,Martina Platzer,Kathrin Kreuzer,Robert Queissner,Bernd Reininghaus,Melanie Lenger,Karin Fabisch,Werner Fitz,Alexandra Kohlhammer-Dohr,Alexandra Krammer,Anna Katharina Holl,Annamaria Painold,Alfred Häussl,Tatjana Maria Stross,Franziska Schmiedhofer,Adelina Tmava-Berisha
INTRODUCTION Sleep disturbances are highly prevalent across most major psychiatric disorders. Alterations in the hypothalamic-pituitary-adrenal axis, neuroimmune mechanisms, and circadian rhythm disturbances partially explain this connection. The gut microbiome is also suspected to play a role in sleep regulation, and recent studies suggest that certain probiotics, prebiotics, synbiotics, and fecal
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Heart Rate Variability for Evaluating Psychological Stress Changes in Healthy Adults: A Scoping Review. Neuropsychobiology (IF 3.2) Pub Date : 2023-06-08 Sarah Immanuel,Meseret N Teferra,Mathias Baumert,Niranjan Bidargaddi
The utility of heart rate variability (HRV) for characterizing psychological stress is primarily impacted by methodological considerations such as study populations, experienced versus induced stress, and method of stress assessment. Here, we review studies on the associations between HRV and psychological stress, examining the nature of stress, ways stress was assessed, and HRV metrics used. The review
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Altered DNA Methylation of the Serotonin Transporter Gene Associated with Early Life Stress and White Matter Microalterations in Korean Patients with Panic Disorder. Neuropsychobiology (IF 3.2) Pub Date : 2023-05-25 Hyun-Ju Kim,Minji Bang,Chun Il Park,Sang-Hyuk Lee
INTRODUCTION Changes in the DNA methylation of 5-HTTLPR are associated with the pathophysiology of panic disorder (PD). This study was conducted to investigate the association between stressful life events and the level of 5-HTTLPR methylation in patients with PD. We also examined whether these factors were associated with white matter alterations in psychological trauma-related regions. METHODS The
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Meta-Analysis of Electroencephalographic Correlates and Cognitive Performance for Acute Exercise-Induced Modulation Neuropsychobiology (IF 3.2) Pub Date : 2023-04-19 Róger Marcelo Martínez, Chenyi Chen, Yang-Teng Fan, Hui-Hua Wu, Pin-Shiuan Du, Guan-Ya Chen, Yu-Chun Chen
Introduction: Although abundant research delving into the acute exercise-induced modulation of cognitive performance and the P300-ERP component has been conducted, there is a lack of consensus regarding whether or not this type of intervention has a beneficial effect on cognition and how it relates to the P300-ERP. Methods: To examine the possible sources of this discrepancy, we conducted a meta-analysis
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Gender-Related Differences in the Relationship between Homovanillic Acid in the Cerebrospinal Fluid and Clinical Symptoms in Suicide Attempters Neuropsychobiology (IF 3.2) Pub Date : 2023-04-14 Sofie Westling, Livia Ambrus
Introduction: Decreased dopaminergic activity – as reflected by lower levels of the major metabolite homovanillic acid (HVA) in cerebrospinal fluid (CSF) – may be involved in the pathophysiology of attempted suicide. An inverse association has also been found between dopaminergic activity and clinical symptoms of depression and anxiety in non-suicidal individuals. The aim of this study was to assess
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Genomic Investigation of Remission and Relapse of Psychotic Depression Treated with Sertraline plus Olanzapine: The STOP-PD II Study Neuropsychobiology (IF 3.2) Pub Date : 2023-04-04 Xiaoyu Men, Victoria Marshe, Samar S. Elsheikh, George S. Alexopoulos, Patricia Marino, Barnett S. Meyers, Benoit H. Mulsant, Anthony J. Rothschild, Aristotle N. Voineskos, Ellen M. Whyte, James Lowery Kennedy, Alastair J. Flint, Daniel J. Müller
Introduction: Little is known regarding genetic factors associated with treatment outcome of psychotic depression. We explored genomic associations of remission and relapse of psychotic depression treated with pharmacotherapy. Methods: Genomic analyses were performed in 171 men and women aged 18–85 years with an episode of psychotic depression who participated in the Study of the Pharmacotherapy of
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Dl-3-n-Butylphthalide Protects against Memory Deficits in Vascular Dementia Rats by Attenuating Pyroptosis via TLR-4/NF-κB Signaling Pathway Neuropsychobiology (IF 3.2) Pub Date : 2023-03-29 Qiang Li, LinNa Shen, Peifen Liang, Yinhua Dong, Tao Fang, LiJun Wang, YiJun Song
Introduction: Inflammation is closely associated with the pathogenesis of vascular dementia (VD). Dl-3-n-butylphthalide (NBP) is a small molecule compound extracted from the seeds of Chinese celery, which have anti-inflammatory properties in animal models of acute ischemia and patients with stroke. In this experiment, we studied the protective effects of NBP in a rat model of VD induced by permanent
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Heartbeat-Evoked Potential in Major Depressive Disorder: A Biomarker for Differential Treatment Prediction between Venlafaxine and rTMS? Neuropsychobiology (IF 3.2) Pub Date : 2023-03-16
Introduction: Currently, major depressive disorder (MDD) treatment plans are based on trial-and-error, and remission rates remain low. A strategy to replace trial-and-error and increase remission rates could be treatment stratification. We explored the heartbeat-evoked potential (HEP) as a biomarker for treatment stratification to either antidepressant medication or rTMS treatment. Methods: Two datasets
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Impaired Decision-Making and Skin Conductance Responses Are Associated with Reward and Punishment Sensitivity in Individuals with Severe Alcohol Use Disorder Neuropsychobiology (IF 3.2) Pub Date : 2023-02-22 Warren B. Logge, Kirsten C. Morley, Paul S. Haber, Andrew J. Baillie
Introduction: Individuals with alcohol use disorder (AUD) have difficulties regulating alcohol consumption, despite adverse drinking-related consequences. This may be due to incapacity incorporating previous negative feedback from drinking, resulting in impaired decision-making. Methods: We assessed whether decision-making is impaired in participants with AUD related to severity of AUD, indexed by
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Changes in Inflammatory Markers in Clinical High Risk of Developing Psychosis Neuropsychobiology (IF 3.2) Pub Date : 2023-02-16 TianHong Zhang, JiaHui Zeng, YanYan Wei, JiaYi Ye, XiaoChen Tang, LiHua Xu, YeGang Hu, HaiChun Liu, Tao Chen, ChunBo Li, JiJun Wang
Introduction: Immune alterations are associated with the progression of psychosis. However, there are few studies designed to longitudinally measure inflammatory biomarkers during psychotic episodes. We aimed to assess changes in biomarkers from the prodromal phase to psychotic episodes in individuals with clinical high risk (CHR) of psychosis and compare converters and non-converters to psychosis
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Erratum Neuropsychobiology (IF 3.2) Pub Date : 2023-02-07 W. Strik, International Pharmaco-EEG Group (IPEG), Werner Konrad Strik, Werner K. Strik, Daniel J. Mueller, Toshihiko Kinoshita, Petra Netter, Alessandro Serretti, P. Netter, Daniela Krneta Messmer, Masahiro Shigeta, Judith M. Ford, Paul Willner, Rainer Schwarting, Thomas Koenig, Laura Mandelli, Michael Maes, Raffaella Calati, Jochen Kindler, Filip Rybakowski, Koichiro Watanabe, Masafumi Yoshimura
Neuropsychobiology
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Modulatory Effects of Ketamine and Lamotrigine on Cognition: Emotion Interaction in the Brain Neuropsychobiology (IF 3.2) Pub Date : 2023-02-02
Introduction: Cognition and emotion are fundamentally integrated in the brain and mutually contribute to behavior. The relation between working memory (WM) and emotion is particularly suited to investigate cognition-emotion interaction since WM is an essential component of many higher cognitive functions. Ketamine affects not only WM but also has a profound impact on emotional processing. Effects of
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Precise Discrimination for Multiple Etiologies of Dementia Cases Based on Deep Learning with Electroencephalography Neuropsychobiology (IF 3.2) Pub Date : 2023-01-19 Masahiro Hata, Yusuke Watanabe, Takumi Tanaka, Kimihisa Awata, Yuki Miyazaki, Ryohei Fukuma, Daiki Taomoto, Yuto Satake, Takashi Suehiro, Hideki Kanemoto, Kenji Yoshiyama, Masao Iwase, Shunichiro Ikeda, Keiichiro Nishida, Yoshiteru Takekita, Masafumi Yoshimura, Ryouhei Ishii, Hiroaki Kazui, Tatsuya Harada, Haruhiko Kishima, Manabu Ikeda, Takufumi Yanagisawa
Introduction: It is critical to develop accurate and universally available biomarkers for dementia diseases to appropriately deal with the dementia problems under world-wide rapid increasing of patients with dementia. In this sense, electroencephalography (EEG) has been utilized as a promising examination to screen and assist in diagnosing dementia, with advantages of sensitiveness to neural functions
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Structural Correlates of Lifetime Voice-Hearing in Patients with Borderline Personality Disorder: A Pilot Study Neuropsychobiology (IF 3.2) Pub Date : 2023-01-12 Katharina M. Kubera, Mike M. Schmitgen, Viviane Hildebrandt, Corinne Neukel, Marie-Luise Otte, Maurizio Sicorello, Sylvia Steinmann, Sabine C. Herpertz, Robert Christian Wolf
Introduction: Auditory verbal hallucinations (AVH) are transdiagnostic phenomena that can occur in several mental disorders, including borderline personality disorder (BPD). Despite the transdiagnostic relevance of these symptoms, very little is known about neural signatures of AVH in BPD. Methods: We used structural magnetic resonance imaging to investigate multiple markers of brain morphology in
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Effect of a Multi-Strain Probiotic Supplementation to Manage Stress during the COVID-19 Pandemic: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Clinical Trial Neuropsychobiology (IF 3.2) Pub Date : 2023-01-12
Introduction: The COVID-19 pandemic strongly affected every aspect of the modern society, from health to socioeconomics, leading people to experience high levels of stress. Methods: A double-blind, cross-over, placebo-controlled clinical study was performed to investigate the ability of a food supplement containing two probiotic strains, Limosilactobacillus reuteri PBS072 and Bifidobacterium breve
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Brain-Derived Neurotrophic Factor Delivered Intranasally Relieves Post-Traumatic Stress Disorder Symptoms Caused by a Single Prolonged Stress in Rats Neuropsychobiology (IF 3.2) Pub Date : 2023-01-11
Introduction: In our previous study, we successfully constructed the recombinant brain-derived neurotrophic factor (BDNF)-adeno-associated virus (AAV) modified by the influenza virus hemagglutinin-2 (HA2) and trans-transcriptional activator (TAT). BDNF-HA2TAT/AAV has been confirmed to have antidepression effects. BDNF-HA2TAT/AAV seems a promising therapy for post-traumatic stress disorder (PTSD) as
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Treatment Resistance in Schizophrenia Is Associated with Attention Deficit/Hyperactivity Disorder and Gut Microbiota: A Genetic Correlation and Mendelian Randomization Study Neuropsychobiology (IF 3.2) Pub Date : 2023-01-09 Bolun Cheng, Shiqiang Cheng, Chun’e Li, Wenming Wei, Li Liu, Peilin Meng, Xuena Yang, Yumeng Jia, Yan Wen, Feng Zhang
Introduction: Observational studies highlight associations of common diseases with individual schizophrenia symptoms. However, it is unclear whether these diseases are associated with individual treatment-resistant schizophrenia (TRS). We aimed to explore the genetic associations between common immune diseases, metabolic diseases, psychiatric disorders, gut microbiota and TRS. Methods: Genome-wide
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Intranasal Oxytocin as Add-On Treatment for Inpatients with Severe Mental Illness: A Randomized Clinical Trial Neuropsychobiology (IF 3.2) Pub Date : 2023-01-05 Ariella Grossman-Giron, Hagai Maoz, Uri Nitzan, Yogev Kivity, Sigal Zilcha-Mano, Yuval Bloch, Shlomo Mendlovic, Dana Tzur Bitan
Introduction: In recent years, several studies were conducted to explore the potential augmenting effect of oxytocin for the treatment of individuals with severe mental illness. Nonetheless, studies exploring its effects in routine inpatient settings using high-quality randomized controlled trials are scarce. The current study assessed the effect of oxytocin administration on treatment process and
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Anxiety Constitutes an Early Sign of Acute Hypoglycemia Neuropsychobiology (IF 3.2) Pub Date : 2022-12-28 Ana G. Gutiérrez García, Carlos M. Contreras
Introduction: Research in humans has identified a link between hypoglycemia and anxiety. The present study examined anxiety-like behaviors in rats that were subjected to hypoglycemia that was produced by an acute injection of insulin. Healthy female Wistar rats were subjected to a battery of tests to explore anxiety (elevated plus maze) and locomotion (open field test). Methods: The control (CT) group
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Clinical Evidence for Association of Acupuncture with Improved Major Depressive Disorder: A Systematic Review and Meta-Analysis of Randomized Control Trials Neuropsychobiology (IF 3.2) Pub Date : 2022-12-22 Guixing Xu, Qiwei Xiao, Biqing Huang, Hanzhou Lei, Zihan Yin, Liuyang Huang, Zhuo Zhou, Hao Tian, Fengyuan Huang, Yilin Liu, Mingsheng Sun, Ling Zhao, Fanrong Liang
Introduction: Depression is the most significant contributor to non-fatal health reductions worldwide. Acupuncture is the most commonly used complementary alternative therapy to relieve major depressive disorder (MDD) effectively. Nevertheless, the effects of acupuncture for MDD are uncertain. This review aimed to determine the efficacy and safety of acupuncture for MDD. Methods: Meta-analysis was
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Acknowledgement to Reviewers Neuropsychobiology (IF 3.2) Pub Date : 2022-12-14
Neuropsychobiology 2022;81:550
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Contents Vol. 81, 2022 Neuropsychobiology (IF 3.2) Pub Date : 2022-12-14
Neuropsychobiology 2022;81:I–VI
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Automatic Approach Behaviors in Alcohol Dependence: Does a Cognitive Bias Modification Training Affect Pavlovian-to-Instrumental Transfer Effects? Neuropsychobiology (IF 3.2) Pub Date : 2022-11-18 Ke Chen, Maria Garbusow, Miriam Sebold, Hilmar G. Zech, Ulrich Zimmermann, Andreas Heinz
Introduction: Positively conditioned Pavlovian cues tend to promote approach and negative cues promote withdrawal in a Pavlovian-to-instrumental transfer (PIT) paradigm, and the strength of this PIT effect was associated with the subsequent relapse risk in alcohol-dependent (AD) patients. When investigating the effect of alcohol-related background cues, instrumental approach behavior was inhibited
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Risk of Major Mental Disorder after Severe Bacterial Infections in Children and Adolescents: A Nationwide Longitudinal Study Neuropsychobiology (IF 3.2) Pub Date : 2022-11-18 Tien-Wei Hsu, Che-Sheng Chu, Shih-Jen Tsai, Ya-Mei Bai, Tung-Ping Su, Tzeng-Ji Chen, Mu-Hong Chen, Chih-Sung Liang
Introduction: Evidence has suggested an association between bacterial infection and increased risk of subsequent major mental disorders (MMDs). Whether such association varies with different pathogens remains unclear. We aimed to investigate the risk of subsequent MMDs after exposure to bacterial pathogens in children and adolescents. Methods: Between 1997 and 2012, we enrolled a nationwide cohort
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The Common Neural Mechanism of Somatic Symptoms of Depression and Anxiety Disorders: A Resting-State Functional Magnetic Resonance Imaging Study Neuropsychobiology (IF 3.2) Pub Date : 2022-11-16
Introduction: Somatic symptoms often occur as a manifestation of depression and anxiety. The subgenual anterior cingulate cortex (sgACC) has been shown to be closely related to both depression and anxiety and plays an important role in somatic symptoms. However, little is known regarding whether the abnormal function of the sgACC contributes to the common somatic symptoms of depression and anxiety
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MMN and P3a Elicited by a Novelty Oddball Paradigm Are Not Reduced in Early-Phase Psychosis Neuropsychobiology (IF 3.2) Pub Date : 2022-11-15 Hayley Riel, Erica Rudolph, Catrina MacPhee, Philip G. Tibbo, Derek J. Fisher
Introduction: The present study compared the mismatch negativity (MMN) and P3a waveforms among early-phase psychosis (EPP; n = 13) individuals and healthy controls (n = 30) to contribute to the research on these waveforms as potential biomarkers for schizophrenia. Methods: MMN and P3a were elicited with a novelty paradigm using complex stimuli with electrophysiological technology. Results: No significant
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Effects of Mindfulness-Based Interventions on Gray Matter Volume in Patients with Opioid Dependence Neuropsychobiology (IF 3.2) Pub Date : 2022-11-14
Introduction: Recently, several mindfulness-based programs showed promising clinical effects in the treatment of psychiatric disorders including substance use disorders. However, very little is known about the effects of mindfulness-based interventions (MBIs) on brain structure in such patients. Methods: This study aimed to detect changes in gray matter volume (GMV) in opioid-dependent patients receiving
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Development of Novel Tasks to Assess Outcome-Specific and General Pavlovian-to-Instrumental Transfer in Humans Neuropsychobiology (IF 3.2) Pub Date : 2022-11-14 Matthew J. Belanger, Hao Chen, Angela Hentschel, Maria Garbusow, Claudia Ebrahimi, Felix G. Knorr, Hilmar G. Zech, Maximilian Pilhatsch, Andreas Heinz, Michael N. Smolka
Introduction: The emergence of Pavlovian-to-instrumental transfer (PIT) research in the human neurobehavioral domain has been met with increased interest over the past two decades. A variety of PIT tasks were developed during this time; while successful in demonstrating transfer phenomena, existing tasks have limitations that should be addressed. Herein, we introduce two PIT paradigms designed to assess
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Effects of Mindfulness-Based Interventions on Gray Matter Volume in Patients with Opioid Dependence. Neuropsychobiology (IF 3.2) Pub Date : 2022-11-14 Robert Christian Wolf,Reham Fahmy,Maha Wasfi,Rania Mamdouh,Kareem Moussa,Mike M Schmitgen,Nadine D Wolf,Dusan Hirjak,Fabio Sambataro,Katharina M Kubera
INTRODUCTION Recently, several mindfulness-based programs showed promising clinical effects in the treatment of psychiatric disorders including substance use disorders. However, very little is known about the effects of mindfulness-based interventions (MBIs) on brain structure in such patients. METHODS This study aimed to detect changes in gray matter volume (GMV) in opioid-dependent patients receiving
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Targeting Learning Mechanisms in Addictive Disorders Neuropsychobiology (IF 3.2) Pub Date : 2022-11-08 Andreas Heinz, Laura Stefanie Daedelow, Franz Moggi
Neuropsychobiology
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Goal-Directed and Habitual Control in Human Substance Use: State of the Art and Future Directions Neuropsychobiology (IF 3.2) Pub Date : 2022-11-04 Nuria Doñamayor, Claudia Ebrahimi, Viktoria A. Arndt, Franziska Weiss, Florian Schlagenhauf, Tanja Endrass
Theories of addiction posit a deficit in goal-directed behavior and an increased propensity toward habitual actions in individuals with substance use disorders. Control over drug intake is assumed to shift from goal-directed to automatic or habitual motivation as the disorder progresses. Several diagnostic criteria reflect the inability to pursue goals regarding reducing or controlling drug use and
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Abnormal Cytokines in Trauma Patients Explained by Obesity, Musculoskeletal Disease, Smoking, and Lung Disease Neuropsychobiology (IF 3.2) Pub Date : 2022-10-27 Erik Ganesh Iyer Søegaard, Zhanna Kan, Hans Christian Dalsbotten Aass, Rishav Koirala, Edvard Hauff, Suraj Bahadur Thapa
Introduction: Low-grade inflammation observed through abnormal plasma cytokine levels has been associated with post-traumatic stress disorder (PTSD). It is not clear whether PTSD independently causes the inflammation or if it is mainly through co-occurring somatic factors such as smoking and obesity. We wanted to explore the effects of biopsychosocial factors on cytokine levels in a clinical setting
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Computational Theories of Alcohol Use Disorder: Mapping Learning and Choice Mechanisms on Symptoms Neuropsychobiology (IF 3.2) Pub Date : 2022-10-20 Miriam Sebold, Stefan J. Kiebel, Michael N. Smolka, Andreas Heinz, Lorenz Deserno
Alcohol use disorder (AUD) is characterized by a combination of symptoms including excessive craving, loss of control, and progressive neglect of alternative pleasures. A mechanistic understanding of what drives these symptoms is needed to improve diagnostic stratification and to develop new treatment and prevention strategies for AUD. To date, there is no consensus regarding a unifying mechanistic
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Family Relationships and Alcohol Consumption: Interaction with the Serotonin Transporter Promoter Polymorphism (5-HTTLPR) Neuropsychobiology (IF 3.2) Pub Date : 2022-08-23 Farzaneh Zareei, Toomas Veidebaum, Jaanus Harro
Introduction: The interaction of environmental and inherited factors determines how a young person becomes involved in problem behaviours such as drinking alcohol. We have investigated whether the association of family relationships with early experience with alcohol is related to variation in the serotonin transporter gene promoter region (5-HTTLPR). Methods: We used data of the two birth cohorts
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Association between the Rostral Anterior Cingulate Cortex and Anterior Insula in the Salience Network on Response to Antidepressants in Major Depressive Disorder as Revealed by Isolated Effective Coherence Neuropsychobiology (IF 3.2) Pub Date : 2022-07-25 Shota Minami, Masaki Kato, Shunichiro Ikeda, Masafumi Yoshimura, Satsuki Ueda, Yosuke Koshikawa, Yoshiteru Takekita, Toshihiko Kinoshita, Keiichiro Nishida
Introduction: Functional connectivity is attracting increasing attention for understanding the pathophysiology of depression and predicting the therapeutic efficacy of antidepressants. In this study, we evaluated effective connectivity using isolated effective coherence (iCoh), an effective functional connectivity analysis method developed from low-resolution brain electromagnetic tomography (LORETA)
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Using Imagination to Integrate Contextual Effects in a Cue-Reactivity Paradigm in Patients with Alcohol Use Disorder: A Functional Magnetic Resonance Imaging Pilot Study Neuropsychobiology (IF 3.2) Pub Date : 2022-07-18 Werner Fey, Frauke Conring, Andrea Federspiel, Leonie Steiner, Franz Moggi, Maria Stein
Introduction: In individuals with alcohol use disorder (AUD), the brain areas underlying cue-induced reactions (e.g., cingulum, striatum, thalamus) and altered activation of these regions have been identified by functional neuroimaging. Neuronal responses to a complex alcohol-related context are yet to investigate. To better understand contextual effects as well as the interplay of cue-induced neural
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Pavlovian-to-Instrumental Transfer across Mental Disorders: A Review Neuropsychobiology (IF 3.2) Pub Date : 2022-07-15 Maria Garbusow, Claudia Ebrahimi, Carlotta Riemerschmid, Luisa Daldrup, Marcus Rothkirch, Ke Chen, Hao Chen, Matthew J. Belanger, Angela Hentschel, Michael N. Smolka, Andreas Heinz, Maximilan Pilhatsch, Michael A. Rapp
A mechanism known as Pavlovian-to-instrumental transfer (PIT) describes a phenomenon by which the values of environmental cues acquired through Pavlovian conditioning can motivate instrumental behavior. PIT may be one basic mechanism of action control that can characterize mental disorders on a dimensional level beyond current classification systems. Therefore, we review human PIT studies investigating
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Genetic Relationships between Attention-Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, and Intelligence Neuropsychobiology (IF 3.2) Pub Date : 2022-06-28 Shuquan Rao, Ancha Baranova, Yao Yao, Jun Wang, Fuquan Zhang
Introduction: Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) commonly co-occur; both traits exert an influence on intelligence scores. Genetic relationships between these three traits are far from being clear. Methods: The summary results of genome-wide association studies of ADHD (20,183 cases and 35,191 controls), ASD (18,381 cases and 27,969 controls), and intelligence
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Neurovegetative and Emotional Modulation Induced by Mozart’s Music Neuropsychobiology (IF 3.2) Pub Date : 2022-06-24 Margherita Di Cesare, Alessandro Tonacci, Danilo Bondi, Vittore Verratti, Giulia Prete, Gianluca Malatesta, Tiziana Pietrangelo
Introduction: Since decades, the “Mozart effect” has been studied. However, the diverse effects of Mozart’s music components have not been yet defined. Authors aimed to identify a differential response to short-term exposure to Mozart’s music, or to its rhythmic signature only, on subjective and objective measures. Methods: The Mozart Sonata in A major K 331 (Mozart), the same piece consisting only
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The Treatment of Substance Use Disorders: Recent Developments and New Perspectives Neuropsychobiology (IF 3.2) Pub Date : 2022-06-20 Annika Rosenthal, Claudia Ebrahimi, Friederike Wedemeyer, Nina Romanczuk-Seiferth, Anne Beck
Substance-related disorders are complex psychiatric disorders that are characterized by continued consumption in spite of harmful consequences. Addiction affects various brain networks critically involved in learning, reward, and motivation, as well as inhibitory control. Currently applied therapeutic approaches aim at modification of behavior that ultimately leads to decrease of consumption or abstinence
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Validation of the Apraxia Screen TULIA (AST) in Schizophrenia Neuropsychobiology (IF 3.2) Pub Date : 2022-04-01 Hanta Bachofner, Konstantin A. Scherer, Tim Vanbellingen, Stephan Bohlhalter, Katharina Stegmayer, Sebastian Walther
Introduction: Deficits in social interaction and community functioning, including impaired use, performance, and perception of hand gestures, are key features in schizophrenia. A well-established tool to assess gesture deficits is the test of upper limb apraxia (TULIA). However, given its time-consuming application based on video analyses, research has proposed the bedside apraxia screen of TULIA (AST)
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Mobile Data Collection of Cognitive-Behavioral Tasks in Substance Use Disorders: Where Are We Now? Neuropsychobiology (IF 3.2) Pub Date : 2022-03-29 Hilmar G. Zech, Markus Reichert, Ulrich W. Ebner-Priemer, Heike Tost, Michael A. Rapp, Andreas Heinz, Raymond J. Dolan, Michael N. Smolka, Lorenz Deserno
Introduction: Over the last decades, our understanding of the cognitive, motivational, and neural processes involved in addictive behavior has increased enormously. A plethora of laboratory-based and cross-sectional studies has linked cognitive-behavioral measures to between-subject differences in drinking behavior. However, such laboratory-based studies inevitably suffer from small sample sizes and
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Dysfunction of the Purinergic System in Bipolar Disorder Neuropsychobiology (IF 3.2) Pub Date : 2022-03-11 Magda Malewska-Kasprzak, Agnieszka Permoda, Janusz K. Rybakowski
Objective: To verify the purinergic hypothesis of bipolar disorder (BD), we assessed the concentration of various components of the purinergic system in manic and depressed bipolar patients. Methods: Sixty-two patients (19 male and 43 female), aged 22–69 (49 ± 14) years, with BD were studied. Twenty-three patients (9 male and 14 female) were assessed during a manic episode and subsequent remission
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Menstrual Cycle-Related Changes in Women with Schizophrenia: A Resting-State fMRI Study Neuropsychobiology (IF 3.2) Pub Date : 2022-03-09 Handan Noyan, Andac Hamamci, Zeynep Firat, Aysegul Sarsilmaz, Alp Ucok
Introduction: Different influences of ovarian hormones in schizophrenia (SCZ) have been reported, but no study to date has assessed their effects on the brain dynamics at rest. The present study aimed to examine the hormonal and clinical changes related to the menstrual cycle and alterations in the resting-state functional connectivity (RS-FC) depending on cycle phase and/or hormonal fluctuations in