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Prevalence of Mental Health Disorders Among Individuals Experiencing Homelessness JAMA Psychiatry (IF 25.8) Pub Date : 2024-04-17 Rebecca Barry, Jennifer Anderson, Lan Tran, Anees Bahji, Gina Dimitropoulos, S. Monty Ghosh, Julia Kirkham, Geoffrey Messier, Scott B. Patten, Katherine Rittenbach, Dallas Seitz
ImportanceSeveral factors may place people with mental health disorders, including substance use disorders, at increased risk of experiencing homelessness and experiencing homelessness may also increase the risk of developing mental health disorders. Meta-analyses examining the prevalence of mental health disorders among people experiencing homelessness globally are lacking.ObjectiveTo determine the
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Digital Mental Health’s Unstable Dichotomy—Wellness and Health JAMA Psychiatry (IF 25.8) Pub Date : 2024-04-17 John Torous, Joseph Firth, Simon B. Goldberg
This Viewpoint discusses the unacknowledged risks and harms and unrealized clinical benefits of digital mental wellness and health technologies and offers suggestions for ways to catalyze the next phase of these technologies by focusing on safety, evidence, and engagement.
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Examining Sex Differences in Autism Heritability JAMA Psychiatry (IF 25.8) Pub Date : 2024-04-17 Sven Sandin, Benjamin H. K. Yip, Weiyao Yin, Lauren A. Weiss, Joseph D. Dougherty, Stuart Fass, John N. Constantino, Zhu Hailin, Tychele N. Turner, Natasha Marrus, David H. Gutmann, Stephan J. Sanders, Benjamin Christoffersson
ImportanceAutism spectrum disorder (ASD) is a neurodevelopmental disorder more prevalent in males than in females. The cause of ASD is largely genetic, but the association of genetics with the skewed sex ratio is not yet understood. To our knowledge, no large population-based study has provided estimates of heritability by sex.ObjectiveTo estimate the sex-specific heritability of ASD.Design, Setting
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Essentials of Informed Consent to Psychedelic Medicine JAMA Psychiatry (IF 25.8) Pub Date : 2024-04-10 Mason Marks, Rebecca W. Brendel, Carmel Shachar, I. Glenn Cohen
ImportanceInterest in administering psychedelic agents as mental health treatment is growing rapidly. As drugmakers invest in developing psychedelic medicines for several psychiatric indications, lawmakers are enacting legal reforms to speed access globally, and health agencies are preparing to approve these treatments. Meanwhile, US states, such as Oregon and Colorado, are making psychedelics available
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Trajectories of Adolescent Media Use and Their Associations With Psychotic Experiences JAMA Psychiatry (IF 25.8) Pub Date : 2024-04-10 Vincent Paquin, Manuela Ferrari, Soham Rej, Michel Boivin, Isabelle Ouellet-Morin, Marie-Claude Geoffroy, Jai L. Shah
ImportanceAdolescent media use is thought to influence mental health, but whether it is associated with psychotic experiences (PEs) is unclear.ObjectiveTo examine longitudinal trajectories of adolescent media use and their associations with PEs at 23 years of age.Design, Setting, and ParticipantsThis cohort study included participants from the Québec Longitudinal Study of Child Development (1998-2021):
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Medicaid Reentry Section 1115 Demonstration Opportunity JAMA Psychiatry (IF 25.8) Pub Date : 2024-04-03 William C. Lieber, Jade Zhang, Lauren Brinkley-Rubinstein
This Viewpoint explains the Medicaid Reentry Section 1115 Demonstration Opportunity of April 2023 and recommends strategies to optimize this opportunity for community connection and mental health care.
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A Dynamical Systems View of Psychiatric Disorders—Theory JAMA Psychiatry (IF 25.8) Pub Date : 2024-04-03 Marten Scheffer, Claudi L. Bockting, Denny Borsboom, Roshan Cools, Clara Delecroix, Jessica A. Hartmann, Kenneth S. Kendler, Ingrid van de Leemput, Han L. J. van der Maas, Egbert van Nes, Mark Mattson, Pat D. McGorry, Barnaby Nelson
ImportancePsychiatric disorders may come and go with symptoms changing over a lifetime. This suggests the need for a paradigm shift in diagnosis and treatment. Here we present a fresh look inspired by dynamical systems theory. This theory is used widely to explain tipping points, cycles, and chaos in complex systems ranging from the climate to ecosystems.ObservationsIn the dynamical systems view, we
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Susceptibility to Treatment-Resistant Depression Within Families JAMA Psychiatry (IF 25.8) Pub Date : 2024-04-03 Chih-Ming Cheng, Mu-Hong Chen, Shih-Jen Tsai, Wen-Han Chang, Chia-Fen Tsai, Wei-Chen Lin, Ya-Mei Bai, Tung-Ping Su, Tzeng-Ji Chen, Cheng-Ta Li
ImportanceAntidepressant responses and the phenotype of treatment-resistant depression (TRD) are believed to have a genetic basis. Genetic susceptibility between the TRD phenotype and other psychiatric disorders has also been established in previous genetic studies, but population-based cohort studies have not yet provided evidence to support these outcomes.ObjectiveTo estimate the TRD susceptibility
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A Dynamical Systems View of Psychiatric Disorders—Practical Implications JAMA Psychiatry (IF 25.8) Pub Date : 2024-04-03 Marten Scheffer, Claudi L. Bockting, Denny Borsboom, Roshan Cools, Clara Delecroix, Jessica A. Hartmann, Kenneth S. Kendler, Ingrid van de Leemput, Han L. J. van der Maas, Egbert van Nes, Mark Mattson, Pat D. McGorry, Barnaby Nelson
ImportanceDynamical systems theory is widely used to explain tipping points, cycles, and chaos in complex systems ranging from the climate to ecosystems. It has been suggested that the same theory may be used to explain the nature and dynamics of psychiatric disorders, which may come and go with symptoms changing over a lifetime. Here we review evidence for the practical applicability of this theory
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Health economics of psychological interventions in PTSD Lancet Psychiatry (IF 64.3) Pub Date : 2024-03-27 Judith Dams
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Cost-effectiveness of therapist-assisted internet-delivered psychological therapies for PTSD differing in trauma focus in England: an economic evaluation based on the STOP-PTSD trial Lancet Psychiatry (IF 64.3) Pub Date : 2024-03-27 Ed Penington MSc, Prof Jennifer Wild DClinPsy, Emma Warnock-Parkes DClinPsy, Nick Grey DclinPsy, Hannah Murray DClinPsy, Alice Kerr DClinPsy, Richard Stott DclinPsy, Alexander Rozental PhD, Prof Gerhard Andersson PhD, Prof David M Clark DPhil, Apostolos Tsiachristas PhD, Prof Anke Ehlers PhD
Although there are effective psychological treatments for post-traumatic stress disorder (PTSD), they remain inaccessible for many people. Digitally enabled therapy is a way to overcome this problem; however, there is little evidence on which forms of these therapies are most cost effective in PTSD. We aimed to assess the cost-effectiveness of the STOP-PTSD trial, which evaluated two therapist-assisted
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Validation of a Multivariable Model to Predict Suicide Attempt in a Mental Health Intake Sample JAMA Psychiatry (IF 25.8) Pub Date : 2024-03-27 Santiago Papini, Honor Hsin, Patricia Kipnis, Vincent X. Liu, Yun Lu, Kristine Girard, Stacy A. Sterling, Esti M. Iturralde
ImportanceGiven that suicide rates have been increasing over the past decade and the demand for mental health care is at an all-time high, targeted prevention efforts are needed to identify individuals seeking to initiate mental health outpatient services who are at high risk for suicide. Suicide prediction models have been developed using outpatient mental health encounters, but their performance
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Genetic and Phenotypic Features of Schizophrenia in the UK Biobank JAMA Psychiatry (IF 25.8) Pub Date : 2024-03-27 Sophie E. Legge, Antonio F. Pardiñas, Grace Woolway, Elliott Rees, Alastair G. Cardno, Valentina Escott-Price, Peter Holmans, George Kirov, Michael J. Owen, Michael C. O’Donovan, James T. R. Walters
ImportanceLarge-scale biobanks provide important opportunities for mental health research, but selection biases raise questions regarding the comparability of individuals with those in clinical research settings.ObjectiveTo compare the genetic liability to psychiatric disorders in individuals with schizophrenia in the UK Biobank with individuals in the Psychiatric Genomics Consortium (PGC) and to compare
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Judy Bass: a global outlook on mental health Lancet Psychiatry (IF 64.3) Pub Date : 2024-03-26 Tony Kirby
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Mental health implementation research in Latin America and the Caribbean Lancet Psychiatry (IF 64.3) Pub Date : 2024-03-26 Eliut Rivera-Segarra, Franco Mascayano, Ana Florence, July Caballero, Leopoldo J Cabassa
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Mental health implementation science: integrating lived experience expertise Lancet Psychiatry (IF 64.3) Pub Date : 2024-03-26 Claudia Sartor, Mujtaba Hussian
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Generating better implementation evidence to improve mental health care everywhere Lancet Psychiatry (IF 64.3) Pub Date : 2024-03-26 Milton L Wainberg, Lidia Gouveia, Karen McKinnon
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Implementation research in mental health: meanings of the term real world Lancet Psychiatry (IF 64.3) Pub Date : 2024-03-26 Claire Henderson
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The Lancet Psychiatry Commission: transforming mental health implementation research Lancet Psychiatry (IF 64.3) Pub Date : 2024-03-26 Prof Emma E McGinty PhD, Prof Margarita Alegria PhD, Prof Rinad S Beidas PhD, Prof Jeffrey Braithwaite PhD, Lola Kola PhD, Prof Douglas L Leslie PhD, Nathalie Moise MD, Prof Bernardo Mueller PhD, Prof Harold A Pincus MD, Rahul Shidhaye MD, Prof Kosali Simon PhD, Prof Sara J Singer PhD, Prof Elizabeth A Stuart PhD, Matthew D Eisenberg PhD
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Interpretation: Time, Timing, Loss, and Recovery in the Analytic Hour J. Am. Psychoanal. Assoc. (IF 0.919) Pub Date : 2024-03-21 Lynne Zeavin
Interpretation remains relevant in contemporary psychoanalysis and serves a crucial linking function between patient and analyst. Interpretation provides an important link with temporalities: the time of the analytic hour and the time of the patient’s history as it unfolds in the present. Analysis, it is argued, is bounded by time and loss. Two case vignettes, presented from a Kleinian perspective
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From the Editors J. Am. Psychoanal. Assoc. (IF 0.919) Pub Date : 2024-03-21 Ann Adelman, Jennifer Stuart, Rachel Boué Widawsky
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What is Meant by the Term Interpretation, and What is it For? J. Am. Psychoanal. Assoc. (IF 0.919) Pub Date : 2024-03-21 Bruce Reis
Analysts seem spellbound by language when it comes to the word interpretation, a word so idealized and grand, so laden with fantasy, that the term itself continues to hold a magical sense that defies us to think about it. Called upon to do far too much explanatory work in psychoanalysis, it is accorded a variety of meanings. It is employed for varied uses, often simultaneously, making it hard to know
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Introduction: W(h)ither Interpretation? J. Am. Psychoanal. Assoc. (IF 0.919) Pub Date : 2024-03-21 Mitchell Wilson
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My Partners in Conversation J. Am. Psychoanal. Assoc. (IF 0.919) Pub Date : 2024-03-21 Mitchell Wilson
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Interpretation as Hypothesis J. Am. Psychoanal. Assoc. (IF 0.919) Pub Date : 2024-03-21 M. Fakhry Davids
Two distinct spaces can be seen as operating in a session—a private one in the analyst’s mind, where formulations take shape, and one shared between patient and analyst, in which interpretations are offered. By maintaining a focus on the here and now in the latter space, taking care to protect it from intrusions from the analyst’s theory except as hypotheses (in the form of interpretations derived
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Book Review: Toward a Unified Psychoanalytic Theory: Foundation in a Revised and Expanded Ego Psychology J. Am. Psychoanal. Assoc. (IF 0.919) Pub Date : 2024-03-21 Eric R. Marcus
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Book Review: The WEIRDest People in the World: How the West Became Psychologically Peculiar and Particularly Prosperous J. Am. Psychoanal. Assoc. (IF 0.919) Pub Date : 2024-03-21 Leon Hoffman
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Barbenheimer Goes to the Gynecologist J. Am. Psychoanal. Assoc. (IF 0.919) Pub Date : 2024-03-21 Jeri Isaacson
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Book Review: The Trauma of Racism: Lessons from the Therapeutic Encounter J. Am. Psychoanal. Assoc. (IF 0.919) Pub Date : 2024-03-21 David Cooper
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The Reflexive Function of Psychoanalytic Interpretation J. Am. Psychoanal. Assoc. (IF 0.919) Pub Date : 2024-03-21 David Lichtenstein
The act of interpretation in psychoanalysis has a distinct character due to the discursive structure of the psychoanalytic setting. The discourse that issues from the interplay of the fundamental rule and evenly suspended attention is a reflection on reflection. The result is that interpretation instead of being a device for inquiry is itself the object of inquiry. Psychoanalysis does not use interpretation
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Interpreting Interpretation J. Am. Psychoanal. Assoc. (IF 0.919) Pub Date : 2024-03-21 Morris N. Eagle
Interpretation of the latent meaning of manifest content is the core of the traditional approach to psychoanalytic treatment. The main purpose of such interpretation is to enhance the patient’s self-knowledge, in particular his or her awareness of unconscious wishes and their embeddedness in inner conflicts. An assumption of classical psychoanalysis is that veridical interpretations—as Freud put it
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Interpretation: Voice of the Field J. Am. Psychoanal. Assoc. (IF 0.919) Pub Date : 2024-03-21 Donnel B. Stern
To patients, the most memorable moments in psychoanalytic treatment are seldom the contents of the analyst’s interpretations, but the feeling of being understood. Interpretations are most meaningful not because of what they say but because each one is evidence that the analyst, who generally becomes someone of great significance to the patient, knows the patient more than before the interpretation
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Social Justice Activism as Interpretation in a Loewaldian World J. Am. Psychoanal. Assoc. (IF 0.919) Pub Date : 2024-03-21 Jyoti M. Rao
At a time when many questions are arising about the nexus between psychoanalysis and social justice, the writings of Hans Loewald open an avenue for broadened conceptualizations of psychoanalytic activity and the role of interpretation within it. The pursuit of social justice, it is argued, is integral to psychoanalytic ethics, and the relation between activists and society can be formulated in Loewaldian
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Barbie, Dressed up in Laplanche J. Am. Psychoanal. Assoc. (IF 0.919) Pub Date : 2024-03-21 Alice X. Huang
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Introduction to Japa’s: Inter-Regional Encylopedic Dictionary Review Series J. Am. Psychoanal. Assoc. (IF 0.919) Pub Date : 2024-03-21 Barbara F. Marcus
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Longitudinal Associations Between Optimism and Objective Measures of Physical Functioning in Women JAMA Psychiatry (IF 25.8) Pub Date : 2024-03-20 Hayami K. Koga, Francine Grodstein, David R. Williams, JoAnn E. Manson, Hilary A. Tindle, Aladdin H. Shadyab, Yvonne L. Michael, Nazmus Saquib, Michelle J. Naughton, Anne-Josee Guimond, Laura D. Kubzansky
ImportanceIdentifying factors contributing to sustained physical functioning is critical for the health and well-being of the aging population, especially as physical functioning may precede and predict subsequent health outcomes. Prior work suggests optimism may protect health, but less is known about the association between optimism and objective physical functioning measures as individuals age.ObjectiveTo
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Baseline Antipsychotic Dose and Transition to Psychosis in Individuals at Clinical High Risk JAMA Psychiatry (IF 25.8) Pub Date : 2024-03-20 Andrea Raballo, Michele Poletti, Antonio Preti
ImportanceEmerging meta-analytical evidence indicates that baseline exposure to antipsychotics is associated with an increased risk of transitioning to psychosis in individuals at clinical high-risk for psychosis (CHR-P) and that such effect is not a result of pretest risk enrichment. However, to maximize its translational utility for prognostic stratification in clinical practice, testing for the
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Decoding Suicide Decedent Profiles and Signs of Suicidal Intent Using Latent Class Analysis JAMA Psychiatry (IF 25.8) Pub Date : 2024-03-20 Yunyu Xiao, Kaiwen Bi, Paul Siu-Fai Yip, Julie Cerel, Timothy T. Brown, Yifan Peng, Jyotishman Pathak, J. John Mann
ImportanceSuicide rates in the US increased by 35.6% from 2001 to 2021. Given that most individuals die on their first attempt, earlier detection and intervention are crucial. Understanding modifiable risk factors is key to effective prevention strategies.ObjectiveTo identify distinct suicide profiles or classes, associated signs of suicidal intent, and patterns of modifiable risks for targeted prevention
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Why treatment manuals of psychological interventions should be freely available Lancet Psychiatry (IF 64.3) Pub Date : 2024-03-18 Pim Cuijpers, Niall Boyce, Mark van Ommeren
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Reciprocal Effects Between Negative Parenting and Children’s Callous-Unemotional Traits From Mid to Late Childhood Am. J. Psychiatry (IF 17.7) Pub Date : 2024-03-13 Patrizia Pezzoli, Jean-Baptiste Pingault, Margherita Malanchini, Ivan Voronin, Eamon McCrory, Pasco Fearon, Essi Viding
Objective: The role of negative parenting in the development of callous-unemotional (CU) traits remains unclear. Both negative parenting and CU traits are influenced by genetic and environmental factors. The authors used genetically informed longitudinal cross-lagged models to examine the extent to which reciprocal effects between negative parenting and children’s CU traits in mid-to-late childhood
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Subcortico-Cortical Dysconnectivity in ADHD: A Voxel-Wise Mega-Analysis Across Multiple Cohorts Am. J. Psychiatry (IF 17.7) Pub Date : 2024-03-13 Luke J. Norman, Gustavo Sudre, Jolie Price, Philip Shaw
Objective: A large body of functional MRI research has examined a potential role for subcortico-cortical loops in the pathogenesis of attention deficit hyperactivity disorder (ADHD), but has produced inconsistent findings. The authors performed a mega-analysis of six neuroimaging data sets to examine associations between ADHD diagnosis and traits and subcortico-cortical connectivity. Methods: Group
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Neuromelanin-Sensitive MRI as Candidate Marker for Treatment Resistance in First-Episode Schizophrenia Am. J. Psychiatry (IF 17.7) Pub Date : 2024-03-13 Marieke van der Pluijm, Kenneth Wengler, Pascalle N. Reijers, Clifford M. Cassidy, Kaithlyn Tjong Tjin Joe, Olav R. de Peuter, Guillermo Horga, Jan Booij, Lieuwe de Haan, Elsmarieke van de Giessen
Objective: Markers for treatment resistance in schizophrenia are needed to reduce delays in effective treatment. Nigrostriatal hyperdopaminergic function plays a critical role in the pathology of schizophrenia, yet antipsychotic nonresponders do not show increased dopamine function. Neuromelanin-sensitive MRI (NM-MRI), which indirectly measures dopamine function in the substantia nigra, has potential
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Durability of Effects of Cognitive Remediation on Cognition and Psychosocial Functioning in Schizophrenia: A Systematic Review and Meta-Analysis of Randomized Clinical Trials Am. J. Psychiatry (IF 17.7) Pub Date : 2024-03-13 Antonio Vita, Stefano Barlati, Anna Ceraso, Gabriele Nibbio, Francesca Durante, Michele Facchi, Giacomo Deste, Til Wykes
Objective: Cognitive remediation provides substantial improvements in cognitive performance and real-world functioning for people living with schizophrenia, but the durability of these benefits needs to be reassessed and better defined. The aims of this study were to provide a comprehensive assessment of the durability of the benefits of cognitive remediation for cognition and functioning in people
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Leanne Williams: fighting stigma through imaging Lancet Psychiatry (IF 64.3) Pub Date : 2024-03-13 Talha Burki
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A museum celebration of the mind Lancet Psychiatry (IF 64.3) Pub Date : 2024-03-13 Jessica Catchpole
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Mental health and support 1 year after the earthquakes in Türkiye Lancet Psychiatry (IF 64.3) Pub Date : 2024-03-13 Gulsah Kurt, Merve Erşahin, A Tamer Aker, Ersin Uygun, Ceren Acartürk
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The ethics of psychiatric management in times of disaster and war: experiences from Israel after the Oct 7 attack Lancet Psychiatry (IF 64.3) Pub Date : 2024-03-13 Rael D Strous, Yaakov Monovich
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Stigma: can we still do more to reduce it? Lancet Psychiatry (IF 64.3) Pub Date : 2024-03-13 Camila Chagas, José Carlos F Galduróz
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5-year mental health outcomes for children and adolescents presenting with psychiatric symptoms to general practitioners in England: a retrospective cohort study Lancet Psychiatry (IF 64.3) Pub Date : 2024-03-13 Morwenna Senior MBBS, Matthias Pierce PhD, Vicky P Taxiarchi PhD, Shruti Garg PhD, Prof Dawn Edge PhD, Tamsin Newlove-Delgado PhD, Sharon A S Neufeld PhD, Prof Kathryn M Abel PhD
Little information is available on the clinical trajectories of children and adolescents who attend general practice (GP) with psychiatric symptoms. We aimed to examine 5-year service use in English primary care for children and adolescents with neurodevelopmental or mental health symptoms or diagnoses. In this retrospective cohort study, we used anonymised primary care health records from the Clinical
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Heterogeneity of outcome measures in depression trials and the relevance of the content of outcome measures to patients: a systematic review Lancet Psychiatry (IF 64.3) Pub Date : 2024-03-13 Christopher Veal MSc, Anneka Tomlinson MD PhD, Prof Andrea Cipriani MD PhD, Samuel Bulteau MD PhD, Prof Chantal Henry MD PhD, Chlöé Müh MSc, Suzanne Touboul PhD, Nikki De Waal MSc, Hana Levy-Soussan MSc, Prof Toshi A Furukawa MD, Eiko I Fried PhD, Prof Viet-Thi Tran MD PhD, Astrid Chevance MD PhD
Research waste occurs when randomised controlled trial (RCT) outcomes are heterogeneous or overlook domains that matter to patients (eg, relating to symptoms or functions). In this systematic review, we reviewed the outcome measures used in 450 RCTs of adult unipolar and bipolar depression registered between 2018 and 2022 and identified 388 different measures. 40% of the RCTs used the same measure
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Adolescent Psychedelic Use and Psychotic or Manic Symptoms JAMA Psychiatry (IF 25.8) Pub Date : 2024-03-13 Otto Simonsson, Miriam A. Mosing, Walter Osika, Fredrik Ullén, Henrik Larsson, Yi Lu, Laura W. Wesseldijk
ImportanceWhile psychedelic-assisted therapy has shown promise in the treatment of certain psychiatric disorders, little is known about the potential risk of psychotic or manic symptoms following naturalistic psychedelic use, especially among adolescents.ObjectiveTo investigate associations between naturalistic psychedelic use and self-reported psychotic or manic symptoms in adolescents using a genetically
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Bright Light Therapy as Add-On to Inpatient Treatment in Youth With Moderate to Severe Depression JAMA Psychiatry (IF 25.8) Pub Date : 2024-03-13 Tanja Legenbauer, Inken Kirschbaum-Lesch, Carina Jörke, Michael Kölch, Olaf Reis, Christoph Berger, Alexander Dück, Michael Schulte-Markwort, Inga Becker-Hebly, Stefanie Bienioschek, Jennifer Schroth, Christian Ruckes, Oliver Deuster, Martin Holtmann
ImportanceMajor depressive disorder is one of the most common mental disorders among adolescents, entailing severe, long-term psychosocial impairment and a high risk of chronicity. In view of the large number of patients requiring treatment, along with insufficient treatment responses with small effect sizes, innovative adjunctive treatment strategies are urgently needed.ObjectiveTo investigate whether
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Mental Health Impairment and Outpatient Mental Health Care of US Children and Adolescents JAMA Psychiatry (IF 25.8) Pub Date : 2024-03-13 Mark Olfson, Chandler McClellan, Samuel H. Zuvekas, Melanie Wall, Carlos Blanco
ImportanceDespite a federal declaration of a national child and adolescent mental health crisis in 2021, little is known about recent national trends in mental health impairment and outpatient mental health treatment of US children and adolescents.ObjectiveTo characterize trends in mental health impairment and outpatient mental health care among US children and adolescents from 2019 to 2021 across
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A milestone in patient-centred care Lancet Psychiatry (IF 64.3) Pub Date : 2024-03-06 Timur Liwinski, Christian G Huber, Undine E Lang
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Open-door policy versus treatment-as-usual in urban psychiatric inpatient wards: a pragmatic, randomised controlled, non-inferiority trial in Norway Lancet Psychiatry (IF 64.3) Pub Date : 2024-03-06 Anne-Marthe Rustad Indregard PhD, Hans Martin Nussle MS, Milada Hagen PhD, Per Olav Vandvik MD PhD, Martin Tesli MD PhD, Jakov Gather MD, Nikolaj Kunøe PhD
Open-door policy is a recommended framework to reduce coercion in psychiatric wards. However, existing observational data might not fully capture potential increases in harm and use of coercion associated with open-door policies. In this first randomised controlled trial, we compared coercive practices in open-door policy and treatment-as-usual wards in an urban hospital setting. We hypothesised that
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Oxidative Stress-Induced Damage to RNA and DNA and Mortality in Individuals with Psychiatric Illness JAMA Psychiatry (IF 25.8) Pub Date : 2024-03-06 Anders Jorgensen, Ivan Brandslund, Christina Ellervik, Trine Henriksen, Allan Weimann, Mikkel Porsborg Andersen, Christian Torp-Pedersen, Per Kragh Andersen, Martin Balslev Jorgensen, Henrik Enghusen Poulsen
ImportanceAll-cause mortality and the risk for age-related medical disease is increased in individuals with psychiatric illness, but the underlying biological mechanisms are not known. Oxidative stress on nucleic acids (DNA and RNA; NA-OXS) is a molecular driver of aging and a potential pathophysiological mechanism in a range of age-related disorders.ObjectiveTo study the levels of markers of NA-OXS
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Virtual Reality and Transcranial Direct Current Stimulation for Posttraumatic Stress Disorder JAMA Psychiatry (IF 25.8) Pub Date : 2024-03-06 Mascha van ’t Wout-Frank, Amanda R. Arulpragasam, Christiana Faucher, Emily Aiken, M. Tracie Shea, Richard N. Jones, Benjamin D. Greenberg, Noah S. Philip
ImportancePosttraumatic stress disorder (PTSD) is a common psychiatric disorder that is particularly difficult to treat in military veterans. Noninvasive brain stimulation has significant potential as a novel treatment to reduce PTSD symptoms.ObjectiveTo test whether active transcranial direct current stimulation (tDCS) plus virtual reality (VR) is superior to sham tDCS plus VR for warzone-related