Open Access
META-ANALYSIS
Ductus Arteriosus Stent Compared with Surgical Shunt for Infants with Ductal-Dependent Pulmonary Blood Flow: A Systematic Review and Meta-Analysis
Sibao Wang, Silin Pan*, Gang Luo, Zhixian Ji, Na Liu
Heart Center, Qingdao Women and Children’s Hospital, Qingdao University, Qingdao 266034, China
* Corresponding Author:Silin Pan. Email:
Congenital Heart Disease 2022, 17(1), 45-60. https://doi.org/10.32604/CHD.2022.016332
Received 01 March 2021; Accepted 27 May 2021; Issue published 26 October 2021
Abstract
The aim of this study was to perform a systematic review and meta-analysis to evaluate the safety and efficacy of
ductus arteriosus stent (DAS) compared with surgical systemic-pulmonary artery shunt (SPS) in patients with
ductal-dependent pulmonary blood flow. A literature search was conducted in PubMed, Embase, and the
Cochrane Library databases from their inception to December 2020. Two reviewers independently screened
the articles, evaluated the quality of the articles, and collected the data. Meta-analyses were conducted using fixed
and random effects models. We used the I-square (I
2
) test to examine heterogeneity and the funnel plot Egger’s
test was used to test for publication bias. We analyzed nine studies including 842 patients were included in the
present study (DAS: n = 295; SPS: n = 547). There was a benefit in favor of DAS group for medium-term mortality
(RR, 0.63; 95% CI, [0.40, 0.99];
P = 0.91, I
2 = 0%). DAS group demonstrated a reduced risk for complications
compared with SPS (RR, 0.46; 95% CI, [0.29, 0.72];
P = 0.78, I
2 = 0%). There was an increased risk for unplanned
reintervention for DAS (RR, 1.77; 95% CI, [1.42, 2.20];
P = 0.61, I
2 = 0%). DAS demonstrated shorter mean intensive care unit length of stay (MD, –5.12; 95% CI, [–7.33, –2.91];
P = 0.005, I
2 = 76%). There was also demonstrated
higher postprocedure oxygen saturation for SPS over DAS (MD, 1.78; 95% CI, [0.92, 2.64];
P = 0.46, I
2 = 0%).
There was no difference between the two groups in terms of mortality within 30 days, Nakata Index, and hospital
length of stay.
Conclusions: In terms of initial palliative surgical in the ductal-dependent pulmonary blood flow,
DAS demonstrated a lower risk of medium-term mortality, lower risk of complications, higher risk of unplanned
reintervention, shorter ICU length of stay, and higher postprocedure oxygen saturation compared with SPS.
Keywords
Cite This Article
APA Style
Wang, S., Pan, S., Luo, G., Ji, Z., Liu, N. (2022). Ductus arteriosus stent compared with surgical shunt for infants with ductal-dependent pulmonary blood flow: A systematic review and meta-analysis. Congenital Heart Disease, 17(1), 45-60. https://doi.org/10.32604/CHD.2022.016332
Vancouver Style
Wang S, Pan S, Luo G, Ji Z, Liu N. Ductus arteriosus stent compared with surgical shunt for infants with ductal-dependent pulmonary blood flow: A systematic review and meta-analysis. Congeni Heart Dis. 2022;17(1):45-60 https://doi.org/10.32604/CHD.2022.016332
IEEE Style
S. Wang, S. Pan, G. Luo, Z. Ji, and N. Liu "Ductus Arteriosus Stent Compared with Surgical Shunt for Infants with Ductal-Dependent Pulmonary Blood Flow: A Systematic Review and Meta-Analysis," Congeni. Heart Dis., vol. 17, no. 1, pp. 45-60. 2022. https://doi.org/10.32604/CHD.2022.016332