Correction: RNA m6A methylation promotes the formation of vasculogenic mimicry in hepatocellular carcinoma via Hippo pathway

Correction to: Angiogenesis (2021) 24:83–96 https://doi.org/10.1007/s10456-020-09744-8

In the original publication, the incorrect images were arranged in Figs. 4H and 6I inadvertently during the figure preparation. The updated Figs. 4 and 6 with the correct images are provided in this correction. The statistical results in Fig. 4I and 6I (right panel) are unaffected by this mistake.

Fig.4

YAP1 promotes VM and cancer progression via an m6A-dependent way in vitro. The Expression of YAP1, METTL3, VE-cadherin, and E-Cadherin in MHCC-97H and HepG2 cells transfected with or without pcDNA-3.1–3 × Flag/YAP1 and siNC/siMETTL3 for 48 h. b Expression of YAP1 and ALKBH5 in MHCC-97H and HepG2 cells transfected with or without pcDNA3.1-AKLBH5. c Expression of YAP1 in MHCC-97H and HepG2 cells treated with VEGFa (24 h) or not. d, e The tube formation of MHCC-97H and HepG2 cells transfected with or without pcDNA-3.1-YAP1 and siNC/siMETTL3 for 48 h were recorded (left)and quantitatively analyzed (right). f, g Wound healing of MHCC-97H and HepG2 cells. h, i Transwell of MHCC-97H and HepG2 cells. All data were represented as mean ± SEM. *p  < 0.05, **p < 0.01, ***pp < 0.001, by Student’s t-test

Fig. 6

Silencing of METTL3 suppresses VM formation and cancer progression in orthotopic transplantation tumor models of HCC. a The expression of METTL3 in stable METTL3 knockdown cell lines by G418 screening. b In vivo Imaging in the BALB/C nude mice. SK-HEP-1-Luc-shMETTL3 (n = 6), and SK-HEP-1-Luc-shControl (n = 6) cell lines were injected into the liver of BALB/C nude mice. c Statistical analysis of the luciferase signal. d Imaging of the luciferase signal of the lungs after dissection. e Statistical analysis of the luciferase signal. f Survival analysis of the BALB/C nude mice. g Formation of HCC metastatic foci in the lung was confirmed by hematoxylin and eosin staining. h Evidence and morphologic observation of VM. The red arrow points to the PAS-positive and CD31-negative vessels lined with tumor cells. The yellow arrow points to the endothelial cell-lined vessels (left). Statistical results of VM in shControl and shMETTL3 groups (right). i METTL3, E-cadherin, VE-cadherin, MMP2, MMP9 and YAP1 expression in the tumor tissues of Vector and shMETTL3 groups were analyzed via IHC. All data were represented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001