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IgG antibody response to pneumococcal-conjugated vaccine (Prevenar®13) in children with immunodeficiency disorders

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Abstract

Measurement of anti-pneumococcal capsular polysaccharides (anti-PnPs) IgG titers is an important tool in the immunologic assessment of patients with suspected immunodeficiency disorders (ID) to reduce the morbi-mortality and minimize severe infections. Retrospectively, we studied the relationship among anti-PnPs IgG response to 3 doses of Prevenar®13, levels of immune system components, leukocyte populations, and clinical data in children with ID. Serum samples were collected at least 4 weeks post vaccination. Subsequently, multi-serotype enzyme-linked immunosorbent assay (ELISA) was performed. Eighty-seven children (under 12 years) were enrolled. Primary immunodeficiency disorder (PID) was the most common disorder (45) followed by possible immunodeficiency disorder (POID) (19), secondary immunodeficiency disorder (SID) (15), and mixed immunodeficiency disorder (MID) (8). The median age was 3 (1.50–5.33) years, 65% of patients were male. Deficient production of anti-PnPs IgG (titer ≤ 50 mg/L) was detected in 47 patients (54%), especially in the MID group, all of them under immunosuppressive therapy. In PCV13 responders, the mean of leukocyte population levels was higher with statistically significance differences in CD4 + /CD8 + T lymphocytes (p = 0.372, p = 0.014) and CD56 + /CD16 + NK (p = 0.016). Patients with previous bone marrow transplantation were the worst PCV13 responders. Pneumococcal IgG antibody titers (post-vaccination) along with clinical and analytical markers represented.

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Abbreviations

PCV:

Pneumococcal-conjugated vaccine

PPSV:

Pneumococcal polysaccharide vaccine

PID:

Primary immunodeficiency disorder

POID:

Possible immunodeficiency disorder

SID:

Secondary immunodeficiency disorder

MID:

Mixed immunodeficiency disorder

ID:

Immunodeficiency disorder

IT:

Immunosuppressive therapy

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Authors and Affiliations

  1. Drug Discovery Unit, Health Research Institute Hospital La Fe, Valencia, Spain

    Marta Garrido-Jareño & Leonor Puchades-Carrasco

  2. Microbiology Department, University and Polytechnic Hospital La Fe, Avenida Fernando Abril Martorell, 106 Torre A 3ª Planta, 46026, Valencia, Spain

    Marta Garrido-Jareño, José Miguel Sahuquillo-Arce, Carmen Lloret-Sos, Ana Gil-Brusola, José Luis López-Hontangas & Javier Pemán-García

  3. Valencian Institute of Pathology, Catholic University of Valencia, Valencia, Spain

    Marta Garrido-Jareño & José Ángel García-García

  4. Respiratory Infection Research Group, Health Research Institute Hospital La Fe, Valencia, Spain

    José Miguel Sahuquillo-Arce

  5. Paediatric Department, University and Polytechnic Hospital La Fe, Valencia, Spain

    Héctor Rodríguez-Vega & Carmen Carreras-Gil de Santivañes

  6. Severe Infection Research Group, Health Research Institute Hospital La Fe, Valencia, Spain

    Ana Gil-Brusola, José Luis López-Hontangas & Javier Pemán-García

  7. Immunology Department, University and Polytechnic Hospital La Fe, Valencia, Spain

    María Nuñez-Beltran

  8. Medical Analysis Department, University and Polytechnic Hospital La Fe, Valencia, Spain

    Jordi Tortosa-Carreres

  9. Hematology Research Group, Health Research Institute Hospital La Fe, Valencia, Spain

    Lourdes Cordón

  10. Molecular Therapeutics Program, Center for Applied Medical Research, University of Navarra, Pamplona, Spain

    Antonio Pineda-Lucena

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  1. Marta Garrido-Jareño
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Garrido-Jareño, M., Sahuquillo-Arce, J.M., Rodríguez-Vega, H. et al. IgG antibody response to pneumococcal-conjugated vaccine (Prevenar®13) in children with immunodeficiency disorders. Med Microbiol Immunol 212, 93–102 (2023). https://doi.org/10.1007/s00430-022-00759-0

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