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Current Genomics

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ISSN (Print): 1389-2029
ISSN (Online): 1875-5488

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Mini-Review Article

Heuristic Analysis of Genomic Sequence Processing Models for High Efficiency Prediction: A Statistical Perspective

Author(s): Aditi R. Durge, Deepti D. Shrimankar* and Ankush D. Sawarkar

Volume 23, Issue 5, 2022

Published on: 07 October, 2022

Page: [299 - 317] Pages: 19

DOI: 10.2174/1389202923666220927105311

Price: $65

Abstract

Genome sequences indicate a wide variety of characteristics, which include species and sub-species type, genotype, diseases, growth indicators, yield quality, etc. To analyze and study the characteristics of the genome sequences across different species, various deep learning models have been proposed by researchers, such as Convolutional Neural Networks (CNNs), Deep Belief Networks (DBNs), Multilayer Perceptrons (MLPs), etc., which vary in terms of evaluation performance, area of application and species that are processed. Due to a wide differentiation between the algorithmic implementations, it becomes difficult for research programmers to select the best possible genome processing model for their application. In order to facilitate this selection, the paper reviews a wide variety of such models and compares their performance in terms of accuracy, area of application, computational complexity, processing delay, precision and recall. Thus, in the present review, various deep learning and machine learning models have been presented that possess different accuracies for different applications. For multiple genomic data, Repeated Incremental Pruning to Produce Error Reduction with Support Vector Machine (Ripper SVM) outputs 99.7% of accuracy, and for cancer genomic data, it exhibits 99.27% of accuracy using the CNN Bayesian method. Whereas for Covid genome analysis, Bidirectional Long Short-Term Memory with CNN (BiLSTM CNN) exhibits the highest accuracy of 99.95%. A similar analysis of precision and recall of different models has been reviewed. Finally, this paper concludes with some interesting observations related to the genomic processing models and recommends applications for their efficient use.

Keywords: Machine learning, genome processing, classification, computational complexity, deep learning, precision and recall.

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