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Mini-Reviews in Organic Chemistry

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ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

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Review Article

Tetra-n-Butyl Ammonium Fluoride (TBAF) as an Efficient Catalyst

Author(s): Mohammed A. Salem, Mohamed H. Helal, Mohammed Al-Ghorbani, Ahmed D.H. Deeb, Eman A. Baz and Moustafa A. Gouda*

Volume 21, Issue 2, 2024

Published on: 01 March, 2023

Page: [229 - 245] Pages: 17

DOI: 10.2174/1570193X20666230111121937

Price: $65

Abstract

Tetra-n-butylammonium fluoride (TBAF) is an organic compound with the formula C16H36FN. It can exist as anhydrous or hydrated (C16H42FNO3). It is soluble in water and THF and utilized as a base in the preparation of triple monoamine reuptake inhibitors, conjugated dienoic acid esters, and polyacetylenic glucosides. This review aims to summarize the chemistry of TBAF.

Keywords: Tetra-n-butylammonium fluoride, multicomponent reactions, fluorination, de-silylation, β-conjugate addition, Suzuki cross-coupling reaction.

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