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Annual Review of Neuroscience

Volume 46, 2023

Therapeutic Potential of PTBP1 Inhibition, If Any, Is Not Attributed to Glia-to-Neuron Conversion

Abstract

A holy grail of regenerative medicine is to replenish the cells that are lost due to disease. The adult mammalian central nervous system (CNS) has, however, largely lost such a regenerative ability. An emerging strategy for the generation of new neurons is through glia-to-neuron (GtN) conversion in vivo, mainly accomplished by the regulation of fate-determining factors. When inhibited, PTBP1, a factor involved in RNA biology, was reported to induce rapid and efficient GtN conversion in multiple regions of the adult CNS. Remarkably, PTBP1 inhibition was also claimed to greatly improve behaviors of mice with neurological diseases or aging. These phenomenal claims, if confirmed, would constitute a significant advancement in regenerative medicine. Unfortunately, neither GtN conversion nor therapeutic potential via PTBP1 inhibition was validated by the results of multiple subsequent replication studies with stringent methods. Here we review these controversial studies and conclude with recommendations for examining GtN conversion in vivo and future investigations of PTBP1.

Keyword(s): astrocytes, dopaminergic neurons, glia-to-neuron conversion, Müller glia, PTBP1 inhibition, reprogramming, retina ganglion cells
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/content/journals/10.1146/annurev-neuro-092822-083410
2023-07-10
2024-04-27
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/content/journals/10.1146/annurev-neuro-092822-083410
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Therapeutic Potential of PTBP1 Inhibition, If Any, Is Not Attributed to Glia-to-Neuron Conversion
Annual Review of Neuroscience 46, 1 (2023); https://doi.org/10.1146/annurev-neuro-092822-083410
/content/journals/10.1146/annurev-neuro-092822-083410
/content/journals/10.1146/annurev-neuro-092822-083410
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