Skip to main content

Advertisement

SpringerLink
Log in

Efficacy of autologous platelet-rich plasma for long-term glucocorticoids caused chronic wound: a case report

  • Published:
Cell and Tissue Banking Aims and scope Submit manuscript

Abstract

The repair of bone explore wounds is one of the difficult problems in plastic and reconstruction surgery. Platelet-rich plasma (PRP) is a safe and efficient therapeutic option for various trauma, including Osteoarticular, musculoskeletal, and Wound injuries. However, the preparation and storage of PRP becomes challenging for patients with poor systemic status and requiring multi-use of PRP. The availability of safe, reliable tissue bank makes it possible. We report a case of a 42-year-old woman patient with a chronic hip wound combined with ischium bone exploration. And the patient who was treated with long-term glucocorticoids for rheumatoid arthritis has been through the experience of extensive conservative management. Thereafter necrosectomy and Vacuum-Assisted Closure (VAC) surgical procedure failed, and a PRP daily injection was performed at the ischial muscle and soft tissue. Neo-muscle appeared around the explored ischium bone after 8 weeks of injection and Complete wound healing was obtained in 3 months.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  • Agarwal P, Kukrele R, Sharma D (2019) Vacuum assisted closure (VAC)/negative pressure wound therapy (NPWT) for difficult wounds: a review. J Clin Orthopaed Trauma 10(5):845–848

    Article  Google Scholar 

  • Boniakowski AE et al (2017) Macrophage-mediated inflammation in normal and diabetic wound healing. J Immunol 199(1):17–24

    Article  CAS  PubMed  Google Scholar 

  • Cain DW, Cidlowski JA (2017) Immune regulation by glucocorticoids. Nat Rev Immunol 17(4):233–247

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Charles-de-Sá L et al (2018) Effect of use of platelet-rich plasma (PRP) in skin with intrinsic aging process. Aesthetic Surg J 38(3):321–328

    Article  Google Scholar 

  • Crowe CS et al (2019) Strategies for reconstruction of the plantar surface of the foot: a systematic review of the literature. Plast Reconstr Surg 143(4):1223–1244

    Article  CAS  PubMed  Google Scholar 

  • Frautschi RS et al (2017) Current evidence for clinical efficacy of platelet rich plasma in aesthetic surgery: a systematic review. Aesthetic Surg J 37(3):353–362

    Google Scholar 

  • Niculet E, Bobeica C, Tatu AL (2020) Glucocorticoid-induced skin atrophy: the old and the new. Clin Cosmet Investig Dermatol 13:1041–1050

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Seth AK et al (2017) Microsurgical burn reconstruction. Clin Plast Surg 44(4):823–832

    Article  PubMed  Google Scholar 

  • Sevilla LM, Pérez P (2018) Roles of the glucocorticoid and mineralocorticoid receptors in skin pathophysiology. Int J Mol Sci 19(7):1906

    Article  PubMed  PubMed Central  Google Scholar 

  • Silverman MN, Sternberg EM (2012) Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction. Ann N Y Acad Sci 1261:55–63

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Suthar M et al (2017) Treatment of chronic non-healing ulcers using autologous platelet rich plasma: a case series. J Biomed Sci 24(1):16

    Article  PubMed  PubMed Central  Google Scholar 

  • Uchiyama R et al (2021) Effect of Platelet-Rich plasma on M1/M2 macrophage polarization. Int J Mol Sci 22(5):2336

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

This work was supported by Grants from the National Natural Science Foundation of China under Grant 82102355.

Author information

Author notes

  1. Ziang Zhang and Jie Long have contributed equally and are co‐first authors.

Authors and Affiliations

  1. Department of Plastic Surgery, Xijing Hospital, Air Force Medical University, Xi’an, Shaanxi Province, China

    Ziang Zhang, Jie Long, Jian Geng & Wensen Xia

Authors
  1. Ziang Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jie Long
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jian Geng
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Wensen Xia
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Jian Geng or Wensen Xia.

Ethics declarations

Conflict of interests

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhang, Z., Long, J., Geng, J. et al. Efficacy of autologous platelet-rich plasma for long-term glucocorticoids caused chronic wound: a case report. Cell Tissue Bank 24, 705–710 (2023). https://doi.org/10.1007/s10561-023-10083-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10561-023-10083-3

Keywords

Search

Navigation