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Vibrio-binding gangliosides in fish intestinal tracts

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Summary

It has been clarified that pathogens bind to glycosphingolipid (GSL) receptors in mammals, but there have been very few reports on pathogen-binding GSLs in fish. Vibrios are facultative anaerobic bacteria ubiquitous in marine and brackish environments. They are members of the normal intestinal microflora of healthy fish, but some species can cause a disease called vibriosis in fish and shellfish when the hosts are physiologically or immunologically weakened. The adherence of vibrios to host intestinal tracts is a significant event not only for survival and growth but also in terms of pathogenicity. We show in this mini-review that sialic acid-containing GSLs (gangliosides), GM4 and GM3, are receptors to which vibrios adhere to epithelial cells in the intestinal tract of fish. We also describe the enzymes responsible for synthesizing these Vibrio-binding gangliosides in fish.

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Data availability statement

The authors declare that all data supporting the findings of this mini-review are available within original articles (10-13) or from the corresponding author upon reasonable request.

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Acknowledgments

We thank Kohei Shimizu, Haruna Kamada, and Yohei Ishibashi at Kyushu University for their technical contribution and valuable suggestions.

Funding

This work was supported by the Japanese Ministry of Education, Culture, Science, and Technology (JP15H04488, JP19H02888).

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Authors and Affiliations

  1. Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School Kyushu University, Motooka 744, Nishi-ku, Fukuoka, 819-0385, Japan

    Makoto Ito, Shinichi Chisada, Naoyuki Matsunaga & Nozomu Okino

  2. Department of Hygiene and Public Health, Kyorin University School of Medicine, Mitaka, Tokyo, 181-8611, Japan

    Shinichi Chisada

  3. Bizen Chemical Co. Ltd., 363 Tokudomi, Akaiwa-shi, Okayama, 709-0716, Japan

    Naoyuki Matsunaga

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  1. Makoto Ito
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  2. Shinichi Chisada
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  4. Nozomu Okino
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Contributions

Writing: M. I; Visualization, S. C., H. M; Validation, S. C., N.O.

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Correspondence to Makoto Ito.

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Ito, M., Chisada, S., Matsunaga, N. et al. Vibrio-binding gangliosides in fish intestinal tracts. Glycoconj J 40, 315–322 (2023). https://doi.org/10.1007/s10719-023-10110-1

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