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A biomechanical view of epigenetic tumor regulation

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Abstract

The occurrence and development of tumors depend on a complex regulation by not only biochemical cues, but also biomechanical factors in tumor microenvironment. With the development of epigenetic theory, the regulation of biomechanical stimulation on tumor progress genetically is not enough to fully illustrate the mechanism of tumorigenesis. However, biomechanical regulation on tumor progress epigenetically is still in its infancy. Therefore, it is particularly important to integrate the existing relevant researches and develop the potential exploration. This work sorted out the existing researches on the regulation of tumor by biomechanical factors through epigenetic means, which contains summarizing the tumor epigenetic regulatory mode by biomechanical factors, exhibiting the influence of epigenetic regulation under mechanical stimulation, illustrating its existing applications, and prospecting the potential. This review aims to display the relevant knowledge through integrating the existing studies on epigenetic regulation in tumorigenesis under mechanical stimulation so as to provide theoretical basis and new ideas for potential follow-up research and clinical applications.

Graphical Abstract

Mechanical factors under physiological conditions stimulate the tumor progress through epigenetic ways, and new strategies are expected to be found with the development of epidrugs and related delivery systems.

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Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

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Funding

This work was supported by National Natural Science Foundation of China (Grant reference number: 11872134), Natural Science Foundation of Hubei, China (Grant reference number: 2022CFA023), and Natural Science Foundation of Chongqing, China (Grant reference number: cstc2020jcyj-msxmX0035).

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  1. Mechanobiology and Regenerative Medicine Laboratory, Bioengineering College, Chongqing University, Chongqing, 400044, People’s Republic of China

    Boyuan Zhao

  2. State Key Laboratory of New Textile Materials and Advanced Processing Technologies, Wuhan Textile University, No. 1 Sunshine Avenue, Jiangxia District, Wuhan, Hubei Province, 430200, People’s Republic of China

    Yonggang Lv

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Zhao, B., Lv, Y. A biomechanical view of epigenetic tumor regulation. J Biol Phys 49, 283–307 (2023). https://doi.org/10.1007/s10867-023-09633-3

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