Recent Progress on Synthesis of Functionalized 1,5-Disubstituted Triazoles

Manoj   K.   Jaiswal; Abhishek      Gupta; Faisal   J.   Ansari; Vinay   K.   Pandey; Vinod   K.   Tiwari
Abstract

Immediately after the invention of ‘Click Chemistry’ in 2002, the regioselective 1,2,3- triazole scaffolds resulted from respective organic azides and terminal alkynes under Cu(I) catalysis have been well recognized as the functional heterocyclic core at the centre of modern organic chemistry, medicinal chemistry, and material sciences. This CuAAC reaction has several notable features including excellent regioselectivity, high-to-excellent yields, easy to execute, short reaction time, modular in nature, mild condition, readily available starting materials, etc. Moreover, the resulting regioselective triazoles can serve as amide bond isosteres, a privileged functional group in drug discovery and development. More than hundreds of reviews had been devoted to the ‘Click Chemistry’ in special reference to 1,4-disubstituted triazoles, while only little efforts were made for an opposite regioisomer i.e., 1,5-disubstituted triazole. Herein, we have presented various classical approaches for an expeditious synthesis of a wide range of biologically relevant 1,5- disubstituted 1,2,3-triazole analogues. The syntheses of such a class of diversly functionalized triazoles have emerged as a crucial investigation in the domain of chemistry and biology. This tutorial review covers the literature assessment on the development of various synthetic protocols for the functionalized 1,5-disubstituted triazoles reported during the last 12 years.
Keywords: Alkyne, azide, cycloaddition, CH-acids, RuAAC, 1, 5-triazole, organocatalyst.
Erratum In:
Recent Progress on Synthesis of Functionalized 1,5-Disubstituted Triazoles
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DOI https://dx.doi.org/10.2174/1570179420666230418123350	Print ISSN 1570-1794
Publisher Name Bentham Science Publisher	Online ISSN 1875-6271
Current Organic Synthesis

Recent Progress on Synthesis of Functionalized 1,5-Disubstituted Triazoles

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Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis

Current Organic Synthesis

Recent Progress on Synthesis of Functionalized 1,5-Disubstituted Triazoles

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Call for Papers in Thematic Issues

Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis

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