Abstract
The data release of Adolescent Brain Cognitive Development® (ABCD) Study represents an extensive resource for investigating factors relating to child development and mental wellbeing. The genotype data of ABCD has been used extensively in the context of genetic analysis, including genome-wide association studies and polygenic score predictions. However, there are unique opportunities provided by ABCD genetic data that have not yet been fully tapped. The diverse genomic variability, the enriched relatedness among ABCD subsets, and the longitudinal design of the ABCD challenge researchers to perform novel analyses to gain deeper insight into human brain development. Genetic instruments derived from the ABCD genetic data, such as genetic principal components, can help to better control confounds beyond the context of genetic analyses. To facilitate the use genomic information in the ABCD for inference, we here detail the processing procedures, quality controls, general characteristics, and the corresponding resources in the ABCD genotype data of release 4.0.
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Acknowledgements
Data used in the preparation of this article were obtained from the Adolescent Brain Cognitive DevelopmentSM (ABCD) Study (https://abcdstudy.org), held in the NIMH Data Archive (NDA). The ABCD Study® is supported by the National Institutes of Health and additional federal partners under award numbers U01DA041048, U01DA050989, U01DA051016, U01DA041022, U01DA051018, U01DA051037, U01DA050987, U01DA041174, U01DA041106, U01DA041117, U01DA041028, U01DA041134, U01DA050988, U01DA051039, U01DA041156, U01DA041025, U01DA041120, U01DA051038, U01DA041148, U01DA041093, U01DA041089, U24DA041123, U24DA041147. A full list of supporters is available at https://abcdstudy.org/federal-partners.html. A listing of participating sites and a complete listing of the study investigators can be found at https://abcdstudy.org/consortium_members/. ABCD consortium investigators designed and implemented the study and/or provided data but did not necessarily participate in the analysis or writing of this report. The contributing members of the ABCD Genetic Working Group include, in alphabetic ordering:
Arpana Agrawal | Department of Psychiatry, School of Medicine, Washington University in St. Louis |
Gaya Dowling | National Institute on Drug Abuse |
Hugh Garavan | Department of Psychological Science, The University of Vermont |
Kimberly LeBlanc | National Institute on Drug Abuse |
Michael Neale | Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University |
Naomi Friedman | Institute for Behavioral Genetics, University of Colorado Boulder |
Pamela Madden | Department of Psychiatry, School of Medicine, Washington University in St. Louis |
Roger Little | National Institute on Drug Abuse |
Sandra A. Brown | Departments of Psychology and Psychiatry, University of California, San Diego |
Terry Jernigan | Center for Human Development, University of California, San Diego |
Wesley K. Thompson | Laureate Institute for Brain Research |
Funding
CCF was supported by grant R01MH122688, RF1MH120025, and R01MH128959 funded by the National Institute for Mental Health (NIMH).
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CCF and RL: wrote the main manuscript. CCF: prepared all the figures. All authors reviewed the manuscript and provided the comments for revisions.
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Chun Chieh Fan, Robert Loughnan, Sylia Wilson, John K. Hewitt, ABCD Genetic Working Group declared that they have no conflict of interest.
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Fan, C.C., Loughnan, R., Wilson, S. et al. Genotype Data and Derived Genetic Instruments of Adolescent Brain Cognitive Development Study® for Better Understanding of Human Brain Development. Behav Genet 53, 159–168 (2023). https://doi.org/10.1007/s10519-023-10143-0
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DOI: https://doi.org/10.1007/s10519-023-10143-0