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Mini-Reviews in Organic Chemistry

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ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

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Mini-Review Article

A Decennial Update on the Applications of Trifluroacetic Acid

Author(s): Mohammed Mujahid Alam, Ravi Varala* and Vittal Seema

Volume 21, Issue 4, 2024

Published on: 08 June, 2023

Page: [455 - 470] Pages: 16

DOI: 10.2174/1570193X20666230511121812

Price: $65

Abstract

Since its discovery at the beginning of the 20th century, trifluoroacetic acid, commonly known as TFA, has seen extensive application in organic synthesis both as a solvent and as a catalyst/ reagent. TFA can be used to facilitate a wide variety of chemical transformations, including rearrangements, functional group deprotections, condensations, hydroarylations and trifluoroalkylations, among others. The decennial mini-review examines key TFA synthetic applications from the middle of 2013 to the present, providing the organic chemistry research community with an opportunity to delve deeply into the numerous and varied applications of this strong acid, water-miscible, and low boiling point reagent.

Keywords: Organic synthesis, reagent, solvent, trifluoroacetic acid (TFA), trifluoromethyl group, catalyst.

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